Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Apolipoprotein A-I: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Proteome: The protein complement of an organism coded for by its genome.Apolipoproteins: Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.Phosphatidylcholine-Sterol O-Acyltransferase: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.Apolipoprotein A-II: The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Lecithin Acyltransferase Deficiency: An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Point Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.Hypolipoproteinemias: Conditions with abnormally low levels of LIPOPROTEINS in the blood. This may involve any of the lipoprotein subclasses, including ALPHA-LIPOPROTEINS (high-density lipoproteins); BETA-LIPOPROTEINS (low-density lipoproteins); and PREBETA-LIPOPROTEINS (very-low-density lipoproteins).Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Polymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.Sus scrofa: A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Sperm Motility: Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Ethnic Groups: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships.CA-125 Antigen: Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Apolipoproteins B: Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.Amyloid: A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Laboratory Animal Science: The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.Animal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Animals, LaboratoryAmino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Amino Acids, Aromatic: Amino acids containing an aromatic side chain.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia. (1/1178)

There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV. This region in turn has been proposed to modulate the expression of hyperlipidemia in the commonest genetic form of dyslipidemia, familial combined hyperlipidemia (FCHL). The hypothesis tested here was whether vitamin A (retinol), by controlling the expression of the AI-CIII-AIV gene cluster, plays a role in modulating the hyperlipidemic phenotype in FCHL. We approached the subject by studying three genetic variants of this region: a C1100-T transition in exon 3 of the apoC-III gene, a G3206-T transversion in exon 4 of the apoC-III gene, and a G-75-A substitution in the promoter region of the apoA-I gene. The association between plasma vitamin A concentrations and differences in the plasma concentrations of apolipoproteins A-I and C-III based on the different genotypes was assessed in 48 FCHL patients and 74 of their normolipidemic relatives. The results indicated that the subjects carrying genetic variants associated with increased concentrations of apoA-I and C-III (C1100-T and G-75-A) also presented increased plasma concentrations of vitamin A. This was only observed among the FCHL patients, which suggested that certain characteristics of these patients contributed to this association. The G3206-T was not associated with changes in either apolipoprotein concentrations or in vitamin A. In summary, we report a relationship between genetically determined elevations of proteins of the AI-CIII-AIV gene cluster and vitamin A in FCHL patients. More studies will be needed to confirm that vitamin A plays a role in FCHL which might also be important for its potential application to therapeutical approaches.  (+info)

Regulation of the human apolipoprotein AIV gene expression in transgenic mice. (2/1178)

The apolipoprotein (Apo) AI-CIII-AIV gene cluster has a complex pattern of gene expression that is modulated by both gene- and cluster-specific cis-acting elements. In particular the regulation of Apo AIV expression has been previously studied in vivo and in vitro including several transgenic mouse lines but a complete, consistent picture of the tissue-specific controls is still missing. We have analysed the role of the Apo AIV 3' flanking sequences in the regulation of gene expression using both in vitro and in vivo systems including three lines of transgenic mice. The transgene consisted of a human fragment containing 7 kb of the 5' flanking region, the Apo AIV gene itself and 6 kb of the 3' flanking region (-7+6 Apo AIV). Accurate analysis of the Apo AIV mRNA levels using quantitative PCR and Northern blots showed that the 7+6 kb Apo AIV fragment confers liver-specific regulation in that the human Apo AIV transgene is expressed at approximately the same level as the endogenous mouse Apo AIV gene. In contrast, the intestinal regulation of the transgene did not follow, the pattern observed with the endogenous gene although it produced a much higher intestinal expression following the accepted human pattern. Therefore, this animal model provides an excellent substrate to design therapeutic protocols for those metabolic derangements that may benefit from variations in Apo AIV levels and its anti-atherogenic effect.  (+info)

Lipid and apolipoprotein predictors of atherosclerosis in youth: apolipoprotein concentrations do not materially improve prediction of arterial lesions in PDAY subjects. The PDAY Research Group. (3/1178)

We compared serum lipid and apolipoprotein predictors of atherosclerosis in cases from the multicenter study, Pathobiological Determinants of Atherosclerosis in Youth (PDAY). The lipid measures included HDL cholesterol (HDL-C) and non-HDL-C, and the apolipoprotein measures included concentrations of apoA1, apoB, and Lp(a), and sizes of the apo(a) proteins. We tested whether the apolipoprotein measures predicted atherosclerotic lesions as well as the more traditional lipid measures. We estimated extent of lesions as fatty streaks or raised lesions (fibrous plaques, complicated or calcified lesions) in 3 sites: thoracic aorta, abdominal aorta, and right coronary artery. Neither apoA1 nor apoB measures were as strongly or consistently correlated with extent of lesions as the corresponding lipid measure (HDL-C and non-HDL-C, respectively). Beyond the basic model that included sex, age, race, smoking status, hypertension, and the lipid measures, apoA1 and apoB added only an average 1.3% increased explanatory ability to the model, whereas HDL-C plus non-HDL-C added an average 2.5%. The results suggest that the traditional lipid measures are more useful than apolipoprotein measures for detecting young persons at high risk of precocious atherosclerosis. Because of large racial differences, the two Lp(a)-related measures, Lp(a) concentrations and apo(a) size, were evaluated in blacks and whites separately. Under these circumstances, neither of the Lp(a)-related measures was strongly or consistently correlated with extent of lesions.  (+info)

Serum lipoprotein(a) and apolipoprotein(a) phenotypes in patients with rheumatoid arthritis. (4/1178)

OBJECTIVE: To determine serum lipoprotein(a) (Lp[a]) concentrations and to analyze the apolipoprotein(a) (Apo[a]) phenotype in patients with rheumatoid arthritis (RA). METHODS: The subjects included 131 patients with RA and 200 healthy control subjects. Serum Lp(a) concentrations were measured by enzyme-linked immunosorbent assay, and the Apo(a) phenotype was determined by immunoblotting. HLA-DR typing was also done. RESULTS: The mean serum Lp(a) level was significantly higher (P < 0.001) in the RA patients (27.5 mg/dl) than in the controls (15.0 mg/dl). The S3 allele was found in 70.0% of the patients versus 39.5% of the controls (P < 0.001). There was no significant difference in HLA-DR4 positivity between patients with and without the S3 phenotype. CONCLUSION: The serum Lp(a) level was increased in patients with RA, possibly partly because of S3 phenotype predominance.  (+info)

Lipoprotein(a) levels and apolipoprotein(a) isoforms related to life style risk factors. (5/1178)

Lipoprotein(a) [Lp(a)] has been considered to be a predictor of premature coronary heart disease and other cardiovascular diseases. Lp(a) levels are largely genetically determined, but the detailed mechanism of Lp(a) elevation is uncertain. We examined the association between Lp(a) levels and apolipoprotein(a) [apo(a)] phenotypes as well as that of Lp(a) level and other various conditions. The subjects were 280 healthy Japanese (102 males and 178 females) aged 39 to 70 years who were living in a rural community in 1992. We obtained apo(a) phenotypes determined by SDS-PAGE as well as Lp(a) levels and other cardiovascular risk factors. We combined apo(a) phenotypes form 4 groups according to molecular weights (from high apo(a) molecular weight to low: I, II, III and IV). Lp(a) levels were associated with apo(a) phenotype-groups, that is, they were inversely associated with apo(a) molecular weight. Small apo(a) phenotypes were less frequent than large ones. The median Lp(a) level was higher in smoking (29.2 mg/dL) than in non-smoking subjects (18.5 mg/dL) in phenotype-group III. Adjusted means of total cholesterol and fibrinogen levels in apo(a) phenotype-group IV were the highest of all phenotype-groups. Age, apo(a) phenotype, smoking status, total cholesterol and fibrinogen were positively correlated with Lp(a) levels by multiple regression analysis. Lp(a) levels were found to be mainly associated with apo(a) phenotype, but varied broadly within the same apo(a) phenotype at various conditions, such as smoking status and high total cholesterol.  (+info)

Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) and Apo(a) fragments. (6/1178)

Fragments of apolipoprotein(a) [apo(a)], the distinctive glycoprotein of lipoprotein(a) [Lp(a)], are present in human plasma and urine and have been implicated in the development of atherosclerosis. The mechanism responsible for the generation of apo(a) fragments in vivo is poorly understood. In this study, we examined the plasma levels of Lp(a) and apo(a) fragments [or free apo(a)] and urinary apo(a) in 15 subjects who underwent cardiac surgery necessitating cardiopulmonary bypass. We also measured the plasma concentration and activity of polymorphonuclear elastase, an Lp(a)-cleaving enzyme in vitro, and plasma levels of C-reactive protein. Despite a marked activation of polymorphonuclear cells and a pronounced inflammatory response, as documented by an 8-fold and a 35-fold increase in plasma levels of polymorphonuclear elastase and C-reactive protein, respectively, the proportion of plasma free apo(a) to Lp(a) and urinary excretion of apo(a) remained unchanged over a 7-day period after surgery, and polymorphonuclear elastase activity remained undetectable in plasma. No fragmentation of apo(a) was observed ex vivo in plasma samples collected before and after surgery. These data indicate that in this model, apo(a) is not fragmented in plasma and are consistent with the hypothesis that apo(a) fragments result from a constitutively active tissue mechanism that is not modified by cardiac surgery with cardiopulmonary bypass.  (+info)

Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma. (7/1178)

Exposure of the LpA1-containing particles present in HDL3 and plasma to a minimal degree of proteolysis by the neutral protease chymase from exocytosed rat mast cell granules (granule remnants) leads to a reduction in the high-affinity component of cholesterol efflux from macrophage foam cells. In this study, we demonstrate for the first time, a role for mast cell chymase in the depletion of the lipid-poor minor components of HDL that are specifically involved in reverse cholesterol transport as initial acceptors of cellular cholesterol. Thus, addition of proteolytically active granule remnants or human skin chymase to cholesterol-loaded macrophages of mouse or human origin incubated with human apoA1, ie, a system in which prebeta1LpA1 is generated, resulted in a sharp reduction in the high-affinity cholesterol efflux promoted by apoA1. As determined by nondenaturing 2-dimensional polyacrylamide gradient gel electrophoresis, the granule remnants effectively depleted the prebeta1LpA1, but not the alphaLpA1, in HDL3 and in plasma during incubation at 37 degrees C for <1 hour. Incubation of plasma with granule remnants for 1 hour also led to near disappearance of the LpA4-1 and LpA4-2 particles, but did not affect the distribution of the apoA2-containing lipoproteins present in the plasma. We conclude that the reduced ability of granule remnant-treated HDL3 and granule remnant-treated plasma to induce cholesterol efflux from macrophage foam cells is caused by selective depletion by mast cell chymase of quantitatively minor A1- and A4-containing subpopulations of HDL. Because these particles, ie, prebeta1LpA1 and LpA4, are efficient acceptors of cholesterol from cell surfaces, their depletion by mast cells may block the initiation of reverse cholesterol transport in vivo and thereby favor foam cell formation in the arterial intima, the site of atherogenesis.  (+info)

Seminal plasma choline phospholipid-binding proteins stimulate cellular cholesterol and phospholipid efflux. (8/1178)

Bovine seminal plasma (BSP) contains a family of phospholipid-binding proteins (BSP-A1/-A2, BSP-A3 and BSP-30-kDa, collectively called BSP proteins) that potentiate sperm capacitation induced by high-density lipoproteins. We showed recently that BSP proteins stimulate cholesterol efflux from epididymal spermatozoa and play a role in capacitation. Here, we investigated whether or not BSP proteins could stimulate cholesterol and phospholipid efflux from fibroblasts. Cells were radiolabeled ([3H]cholesterol or [3H]choline) and the appearance of radioactivity in the medium was determined in the presence of BSP proteins. Alcohol precipitates of bovine seminal plasma (designated crude BSP, cBSP), purified BSP-A1/-A2, BSP-A3 and BSP-30-kDa proteins stimulated cellular cholesterol and choline phospholipid efflux from fibroblasts. Efflux mechanistic differences were observed between BSP proteins and other cholesterol acceptors. Preincubation of BSP-A1/-A2 proteins with choline prevented cholesterol efflux, an effect not observed with apolipoprotein A-I. Also, the rate of BSP-induced efflux was rapid during the first 20 min, but leveled off thereafter in contrast to a relatively slow, but constant, rate of cholesterol efflux mediated by apolipoprotein A-I, apolipoprotein A-I-containing reconstituted lipoproteins (LpA-I) and high-density lipoproteins. These results indicate that fibroblasts are a good cell model to study the mechanism of lipid efflux mediated by BSP proteins.  (+info)

*Apolipoprotein

... synthesis in the intestine is regulated principally by the fat content of the diet. Apolipoprotein synthesis in ... There are also intermediate-density lipoproteins formed by Apolipoprotein E. There are six classes of apolipoproteins and ... There are two major types of apolipoproteins. Apolipoproteins B form low-density lipoprotein (sometimes referred to as "bad ... Apolipoprotein L Saito H, Lund-Katz S, Phillips MC (July 2004). "Contributions of domain structure and lipid interaction to the ...

*Apolipoprotein E

... is a fat-binding protein (apolipoprotein) that is part of the chylomicron and Intermediate-density lipoprotein ... The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC-I) and the apolipoprotein C2. The APOE ... "Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of ... Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body. It is important in Alzheimer's ...

*Apolipoprotein C3

Karathanasis SK (Oct 1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV ... Apolipoprotein C-III also known as apo-CIII is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component ... Apolipoprotein C-III at the US National Library of Medicine Medical Subject Headings (MeSH) Human APOC3 genome location and ... Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK (Jul 1985). "Distribution of apolipoprotein A-I, C-II, C-III, and E ...

*Apolipoprotein O

... is the first chondroitine sulphate chain containing apolipoprotein. Apolipoproteins are proteins that binds to ... APOO is a member of the apolipoprotein family. The human, apolipoprotein O is a 198 amino acids protein that contains a 23 ... Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. ... 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. ...

*Apolipoprotein C2

... or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this ... 1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. ... Connelly PW, Maguire GF, Little JA (1988). "Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated ... "Entrez Gene: APOC2 apolipoprotein C-II". Jackson RL, Baker HN, Gilliam EB, Gotto AM (1977). "Primary structure of very low ...

*Apolipoprotein C4

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene. Apolipoprotein ... 2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex ... 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical ... Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid ...

*Apolipoprotein C

In the field of molecular biology, apolipoprotein C is a family of four low molecular weight apolipoproteins, designated as C-I ... In the fasting state, the C apolipoproteins are mainly associated with HDL. During absorption of dietary fat, the C apoli- ... Mahley RW, Innerarity TL, Rall SC, Weisgraber KH (December 1984). "Plasma lipoproteins: apolipoprotein structure and function ...

*Apolipoprotein A1

... is a protein that in humans is encoded by the APOA1 gene. It has a specific role in lipid metabolism. The ... Apolipoprotein A1 is the major protein component of HDL particles in plasma. Chylomicrons secreted from the intestinal ... Apolipoprotein A1 and APOE interact epistatically to modulate triglyceride levels in coronary heart disease patients. ... Described in 1980, it was the first known molecular abnormality of apolipoproteins. Paradoxically, carriers of this mutation ...

*Apolipoprotein C1

1988). "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene". J. Biol. Chem. 263 ( ... Myklebost O, Rogne S (1986). "The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene ... Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene. The protein encoded by ... "Entrez Gene: APOC1 apolipoprotein C-I". Human APOC1 genome location and APOC1 gene details page in the UCSC Genome Browser. ...

*Apolipoprotein L1

... is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different ... Apolipoprotein L1 (apoL1) is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is ... It forms a complex with high-density lipoprotein 3 (HDL3) particles that also contain apolipoprotein A1 (APOA1) and the ... hemoglobin-binding, haptoglobin-related protein (HPR). It is a member of a family of apolipoproteins which consists of 6 other ...

*Apolipoprotein D

"Entrez Gene: APOD apolipoprotein D". Muffat J, Walker DW (2010). "Apolipoprotein D: an overview of its role in aging and age- ... Apolipoprotein D (Apo-D) is a component of high-density lipoprotein that has no marked similarity to other apolipoprotein ... Apolipoproteins D at the US National Library of Medicine Medical Subject Headings (MeSH) Applied Research on Apolipoproteins ... Apolipoprotein D is a protein that in humans is encoded by the APOD gene. Unlike other lipoproteins, which are mainly produced ...

*Apolipoprotein B

... (ApoB) is a protein that in humans is encoded by the APOB gene. Apolipoprotein B is the primary apolipoprotein ... Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, Adeli K (2009). "Apolipoprotein B100 acts as a molecular link between lipid- ... MedlinePlus Encyclopedia Apolipoprotein B100 McQueen MJ, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J, Steyn K, ... Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver ...

*Apolipoprotein A2

Apolipoprotein A-II is an apolipoprotein found in high density lipoprotein (HDL) cholesterol in plasma. It has an approximate ... High HDL Cholesterol (Hyperalphalipoproteinemia) at eMedicine Apolipoprotein A-II at the US National Library of Medicine ...

*Apolipoprotein L

... (Apo L) belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The ... reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for ...

*Apolipoprotein H

... at the US National Library of Medicine Medical Subject Headings (MeSH) Apolipoprotein H and Applied Research ... serum phospholipids and are called anti-apolipoprotein antibodies. In autoimmune disease, anti-apolipoprotein antibodies (Anti ... Apolipoprotein H (Apo-H), previously known as β2-glycoprotein I and beta-2 glycoprotein I, is a 38 kDa multifunctional ... The first four domains found in Apolipoprotein H resemble each other, however the fifth one appears to be different. This ...

*Anti-apolipoprotein antibodies

In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a ...

*Apolipoprotein B deficiency

... (also known as "Familial defective apolipoprotein B-100") is an autosomal dominant disorder ...

*Apolipoprotein B (apoB) 5' UTR cis-regulatory element

The apolipoprotein B (apoB) 5' UTR cis regulatory element is an RNA element located in the 5' UTR of the human apoB mRNA. This ... Pontrelli, L; Sidiropoulos KG; Adeli K (2004). "Translational control of apolipoprotein B mRNA: regulation via cis elements in ... Page for Apolipoprotein B (apoB) 5' UTR cis-regulatory element at Rfam. ...

*Lipocalin

... apolipoprotein D; beta-lactoglobulin; complement component C8 gamma chain; crustacyanin; epididymal-retinoic acid binding ...

*ApoA-1 Milano

Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 ... Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR (25 February 1983). "Apolipoprotein A-IMilano. ...

*APOA2

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. This gene encodes apolipoprotein (apo-) A-II, ... "Entrez Gene: APOA2 apolipoprotein A-II". Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998 ... Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein ... The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result ...

*Low-density lipoprotein receptor-related protein 8

Apolipoprotein E (ApoE) plays an important role in phospholipid and cholesterol homeostasis. After binding ApoER2, ApoE is ... Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the ... Herz J (June 2009). "Apolipoprotein E receptors in the nervous system". Curr. Opin. Lipidol. 20 (3): 190-6. doi:10.1097/MOL. ... Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein ...

*APOM

Apolipoprotein M is a protein that in humans is encoded by the APOM gene. The protein encoded by this gene is an apolipoprotein ... "Entrez Gene: APOM apolipoprotein M". Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes ... 2004). "Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is ... 2005). "Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells". Biochim. ...

*APOL3

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL3 apolipoprotein L, 3". Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser. ... 2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. ... Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution ...

*Gladstone Institutes

Alzheimer's disease and apolipoprotein E (apoE). Uncovered the molecular pathways that link apoE and Alzheimer's disease, and ...
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TY - JOUR. T1 - Gender and ethnic differences in a case-control study of dyslipidemia. T2 - using the apolipoprotein A-V gene as an exemplar in cardiovascular genetics.. AU - Wung, Shu Fen. AU - Aouizerat, Bradley. PY - 2003. Y1 - 2003. N2 - Common, complex genetic disorders such as coronary heart disease (CHD) frequently show large population differences, contributing to health disparities. It is also well known that CHD risk factor profiles and the frequency of coronary events differ by gender. Study of premature CHD has revealed that apolipoproteins are important discriminating factors for distinguishing individuals with CHD. Recent findings indicated that apolipoprotein A-V (APOA-V) gene promoter polymorphisms are an important determinant of plasma triglycerides (TG) and lipoprotein cholesterol, and a risk factor for CHD. Variations in APOA-V may have varying impacts in different ethnic groups. The purpose of this interdisciplinary genetic research project was to determine (1) the ...
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Chemicals / CAS: lipoprotein lipase, 83137-80-8, 9004-02-8; APOA5 protein, human; Apolipoproteins A; Apolipoproteins; Triglycerides ...
SNPs in the apolipoprotein A-V gene, APOA5, have primarily been associated with plasma lipoprotein levels and associated downstream consequences, such as weight gain and heart disease risk. Significant SNPs of APOA5 include: ...
Apolipoproteins have multiple roles. One role is to increase the overall solubility of the lipid particle, helping it to dissolve in the aqueous environment of the blood (apolipoproteins are amphipathic, or detergent-like proteins). Apolipoproteins can also function as enzyme co-factors (receptor ligands), facilitating the transfer of their lipid cargo to specific cells. Thus, the apoliproteins are the "smart" or working-end of the lipoprotein particle. The apolipoproteins dictate where the particles will dock and where they can bind, and in so doing the apolipoproteins regulate lipid metabolism in the body. So although the particles are composed of phospholipids and have lipid cargo, the few proteins on their surface are what give them their collective name of lipoproteins ...
Apolipoproteins have important structural and functional roles in several lipoprotein particles. Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major...
[55 Pages Report] Check for Discount on Apolipoprotein A-I (ApoA-I) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Apolipoprotein A-I (ApoA-I) - Pipeline...
Polyclonal antibody for APOA I/APOA1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. APOA I/APOA1 information: Molecular Weight: 30778 MW; Subcellular Localization: Secreted; Tissue Specificity: Major protein of
Half Way Home A Novel (Book) : Howey, Hugh : Five hundred of us were sent to colonize this planet. Only fifty of us survived. We woke up fifteen years too early. We had only half our training. And they expected us not only to survive-- They expected us to conquer this place. The problem is: It isnt safe here. We arent even safe from each other.--P. [4] of cover.
In a previous proteomics study using pooled cerebrospinal fluid (CSF) samples, we proposed apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-β-his-dipeptidase as candidate biomarkers associated with the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndromes (CIS). Here, we aimed to validate these results in individual CSF samples using alternative techniques. In a first replication study, levels of apolipoproteins AI and AIV, vitronectin, and plasminogen were measured by ELISA in CSF and serum of 56 CIS patients (29 patients who converted to CDMS (MS converters) and 27 patients who remained with CIS during follow-up (MS non-converters)) and 26 controls with other neurological disorders. Semaphorin 7A and ala-β-his-dipeptidase levels were determined by selected reaction monitoring (SRM) in CSF of 36 patients (18 MS converters, 18 non-converters) and 20 controls. In a second replication study, apolipoprotein AI
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The RT² qPCR Primer Assay is the most reliable SYBR® Green-based quantitative real-time PCR assay for gene expression analysis. Our experimentally verified design algorithm yields gene-specific qPCR assays characterized by uniform and high PCR efficiencies and standardized amplification conditions. Every RT² Primer Assay is subjected to rigorous experimental verification. Single product amplification of the correct size and high PCR efficiency are guaranteed when using the appropriate RT² qPCR Master Mixes. The uniform PCR amplification efficiencies and PCR conditions of the RT² qPCR Primer Assays provide an accurate and scalable solution for multiple gene expression analyses. Browse Primer Assays By Gene ...
The RT² qPCR Primer Assay is the most reliable SYBR® Green-based quantitative real-time PCR assay for gene expression analysis. Our experimentally verified design algorithm yields gene-specific qPCR assays characterized by uniform and high PCR efficiencies and standardized amplification conditions. Every RT² Primer Assay is subjected to rigorous experimental verification. Single product amplification of the correct size and high PCR efficiency are guaranteed when using the appropriate RT² qPCR Master Mixes. The uniform PCR amplification efficiencies and PCR conditions of the RT² qPCR Primer Assays provide an accurate and scalable solution for multiple gene expression analyses. Browse Primer Assays By Gene ...
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High-density lipoprotein is predominantly composed of the apolipoproteins apoAI and apoAII. These apolipoproteins are responsible for collecting lipids from arteries and transporting them back to the liver for reutilization, which provides protection against cardiovascular diseases. While many studies examine the cardiovascular effects of HDL and its apolipoproteins, few have looked at whether these molecules maintain the health of other bodily systems and organs. In this study, the authors show that apoA1 maintains pulmonary function in mice. Along with inhibiting stressors such as proinflammatory HDL formation and the activity of paranoxonase 1 (PON1) and 3-nitrotyrosine (3NT) in the plasma, apoA1 was shown to limit pulmonary inflammation and oxidative stress markers, such as 3NT, 4-hydroxynonenal adducts (4-HNE), transforming growth factor-β (TGFβ), xanthineoxidase, myeloperoxidase and endothelial nitric oxide synthase in the lung milieu. Additionally, apoA1 was shown to enhance arterial ...
Blog on anti-Apo antibody product: The Apo lpa (Catalog #MBS534186) is an Antibody produced from Goat and is intended for research purposes ...
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Recombinant mammalian apolipoproteins have been expressed in a variety of cultured mammalian cell lines (Reardon et al. 1986; Mallory et al. 1987; Blackhart et al. 1990; Yao et al. 1991), transgenic...
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APOA5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids (24-366 a.a.) and having a molecular mass of 41.3kDa.
Hans was a busy, happy, sweet and fearless three year old when he was diagnosed with Neuroblastoma. He fought his disease like a "gladiator" for nearly 6 years. Hans was an animal lover to his core. He was guarded at home by his three cats, Black, Orange and Cotton. He also had his Golden Retriever, Honey, to keep him company. Hans enjoyed swimming, biking, gardening, grilling (he had his very own grill!), horseback riding, playing video games, building Legos, and flipping between Nickelodeon, Cartoon Network and Animal Planet. Hans loved all members of his family and he was a loyal friend. He had to go through a lot of treatment in his life. But Hans powered through it. His attitude was lets get this done! His motivation was always to get back home, to his family, pets, favorite foods and pool ...
To explore the potential of the common marmoset monkey (Callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. Based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) A-I, A-II, C-III, and A-IV. The first 54 residues of marmoset apo A-I showed 87% sequence identity with the corresponding region of human apo A-I. Amino-terminal sequence analysis of a minor basic apo A-I isoform revealed that it contained an amino-terminal hexapeptide extension (Arg-His-Phe-Gln-Gln-) identical to that found in human proapo A-I. Like apo A-II in most nonhuman primates, marmoset apo-A-II differed from human apo A-II in that it did not contain cysteine and therefore existed as a monomer. The complete amino acid sequence of marmoset apo A-II was deduced. The protein contains 77 amino acids, as does human ...
Site-directed mutagenesis and other molecular biology-based techniques are now available for probing the amphipathic alpha-helix structural motif in the exchangeable apolipoproteins. Here we survey the published literature on lipid-binding and functional domains in apolipoproteins A-I, A-II, A-IV, C-I, C-II, C-III, and E and compare these results with recently developed computer methods for analysis of the location and properties of amphipathic helixes. This comparison suggests that there are at least three distinct classes of amphipathic helixes (classes A, Y, and G*) in the exchangeable apolipoproteins whose distribution varies within and between the seven apolipoproteins. This comparison further suggests that lipid affinity resides largely in class A amphipathic helixes (Segrest, J. P., et al. 1990. Proteins. 8: 103) and that variations in structure and/or numbers of class A domains in individual apolipoproteins allow a range of lipid affinities from high to low. The positions of the four a ...
The expression of the apolipoprotein A-I (apo A-I) gene was investigated in the myelinating sciatic nerve. Hybridization analysis with an apo A-I cDNA probe obtained from a cDNA library of mRNA isolated from rapidly myelinating chick sciatic nerve indicated that apo A-I coding transcripts increase during development in the chick sciatic nerve in parallel with the increase of myelin lamellae. Substantial apo A-I-like immunoreactivity in chick sciatic nerve homogenates was detected by Western blotting. The amount of antigen increased from the 15-d embryonic stage to 1 d posthatch and then decreased. Two subcellular fractions corresponding to the cytoplasmic compartments were particularly enriched in apo A-I. apo A-I immunoreactivity was also found in highly purified myelin preparations. Immunohistochemical staining provided further evidence for the presence of apo A-I in the endoneurial compartment of the sciatic nerve. Electron microscopic examination of these fractions after negative staining ...
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues. In lipid transport, apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. In particular, apoA1 is the major protein component of high-density lipoproteins; apoA4 is thought to act primarily in ...
TY - JOUR. T1 - Purification of biologically active apolipoproteins by chromatofocussing. AU - McLeod, Roger. AU - Lacko, Andras G.. AU - Pritchard, P. Haydn. AU - Frohlich, Jiri. PY - 1986/1/1. Y1 - 1986/1/1. N2 - Chromatofocussing has been used to isolate homogeneous apolipoproteins (apo) from human very-low-density lipoproteins and high-density lipoproteins with protein recovery of 70%. The inclusion of sulfhydryl-reducing agent (dithiothreitol) was required during solubilization of the lipoproteins (following delipidation) to achieve reproducible elution profiles. Removal of polyvalent buffers from apoproteins was rapidly accomplished on small columns of hydroxylapatite. The biological activity of purified apo AI and apo CII was confirmed by assessment of their ability to activate lecithin:cholesterol acyltransferase or lipoprotein lipase, respectively. Functional properties of isolated apo E were assessed by in vitro interaction with the low-density lipoprotein receptor expressed by ...
This Human Apo AIV ELISA is used to measure & quantify Apo AIV levels in Metabolism research. Find MSDS or SDS, a COA, data sheets and more information.
ProSpecs Apolipoproteins include: Clusterin Human Recombinant, Clusterin Rat Recombinant, Apolipoprotein-D Human Recombinant, Human Apolipoprotein-J, Apolipoprotein-J Canine Recombinant
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References for Abcams Human Apolipoprotein A I peptide (ab66674). Please let us know if you have used this product in your publication
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Apolipoprotein A2 antibody (HRP) (apolipoprotein A-II) for ELISA. Anti-Apolipoprotein A2 pAb (GTX40825) is tested in Human samples. 100% Ab-Assurance.
Polyclonal antibodies raised against a range of seed apolipoproteins from the family Cruciferae have been used for the first time for low resolution epitope characterisation. Antibodies were raised against the major seed apolipoproteins of Brassica napus, Sinapis alba and Raphanus sativum. In each case, the antibodies recognized, in addition to the 19-20 kDa apolipoprotein to which they were raised, similar 19-20 kDa apolipoproteins from a wide range of species in the family Cruciferae, but not in other plant families. Homologous or heterologous two-sites (sandwich) assays were performed with the format [antibody A - test apolipoprotein - antibody B - 2° antibody]. The results showed a drastically reduced antibody B binding by apolipoproteins preincubated with an antibody A. This indicated the presence of a single major epitope on many of the apolipoproteins. The antigenicity of native and denatured apolipoproteins was similar, although the antigenicity of the former was much more readily ...
Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
Abstract: Enzyme-linked immunosorbent assay (ELISA) has been used formeasuring apolipoproteins A-I and B in the urine. ApoB is absentin urine of healthy subjects, and apoA-I is determined in tracequantity. In patients with chronic glomerulonephritis quantity ofapoA-I in urine was 117 times as much as in control group. ApoBis present in urine of patients in considerable quantity(1528*315 *g/l).) The ELISA method for determining apoA-I andapoB in urine makes it possible to evaluate the gravity ofpathological process in kidney ...
Apolipoproteins are carrier proteins that bind lipids to form water-soluble lipoprotein particles that can be carried through blood and lymph. Several different classes and subclasses of apolipoproteins are known. Apolipoprotein B (ApoB) is the primary apolipoprotein in chylomicrons (lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins) and low-density lipoprotein (LDL). It is also known as FLDB and LDLCQ4. High levels of ApoB can lead to plaques that cause atherosclerosis, and ApoB levels can be a better indicator of heart disease risk than total cholesterol or LDL. The APOB transcript is subject to tissue-specific RNA editing, resulting in two major isoforms, ApoB-100 and ApoB-48.. ...
Human apolipoprotein (apo) A-I is secreted as a proprotein of 249 amino acids and is processed extracellularly to the mature form (243 amino acids) by removal of a six-residue propeptide segment. We have examined the role of the apoA-I propeptide in intracellular transport and secretion using transfected baby hamster kidney cells that secreted either proapoA-I (from the wild-type cDNA, A-Iwt) or mature-form apoA-I (from A-I delta pro, a cDNA in which the propeptide sequence was deleted). Deletion of the propeptide from the apoA-I sequence did not affect the rate of apoA-I synthesis, nor did it affect the fidelity of proteolytic removal of the prepeptide. However, the propeptide deletion caused mature-form apoA-I to accumulate within the cells as determined by pulse-chase experiments; the intracellular retention times for the mature-form apoA-I in which the propeptide was prematurely removed was three times longer than that of proapoA-I (t1/2 , 3 h compared with approximately 50 min). There was ...
Apolipoprotein A-I (apo A-I) is the most abundant protein in high-density lipoprotein (HDL) particles, and it plays an important role in HDL metabolism. Both apo A-I and HDL cholesterol (HDL-C) levels are inversely associated with risk of cardiovascular disease. Segregation analyses suggest apo A-I levels are under the control of one or more major loci. Since HDL particles are heterogeneous in their composition and size, genetic influence on its subfractions (i.e., HDL2 and HDL3) could vary. A previous report showed evidence of a major locus controlling HDL3-C levels in a subset of the current study population. Because quantitative trait loci involved in complex diseases are likely to have pleiotropic effects on several related traits, it is possible to have a common major gene involved in regulating apo A-I and HDL3-C levels. We performed a bivariate segregation analysis of apo A-I and HDL3-C levels in 1,006 individuals from 137 families ascertained through probands undergoing elective, diagnostic
Recombinant Human Apolipoprotein A I Full length protein datasheet (ab50239). Abcam offers quality products including antibodies, assays and other reagents.
TY - JOUR. T1 - Genetic control of apolipoprotein A-I distribution among HDL subclasses. AU - Rainwater, David L.. AU - Blangero, John. AU - Moore, Perry H.. AU - Shelledy, Wendy R.. AU - Dyer, Thomas D.. PY - 1995. Y1 - 1995. N2 - We conducted genetic analyses to determine the components of variation for size distributions of apolipoprotein (apo) A-I among human plasma lipoproteins resolved on the basis of size. Analyses used data for 717 individuals in 26 pedigrees. Apo A-I distributions among lipoprotein size classes were measured by nondenaturing gradient gel electrophoresis (GGE) and immunoblotting procedures. Curves were fitted to apo A-I absorbance profiles to estimate fractional absorbance in each of five high-density lipoprotein (HDL) subclasses. Multivariate regression analyses revealed several covariates (sex, age, diabetes, and apo A-I concentrations) that were significantly associated with variation in one or more HDL subclasses. Female gender and elevated apo A-I concentrations ...
We hypothesized that impaired protection of HDL against apoB-containing lipoprotein oxidation in the 11.1 transgenic mouse model could play a role in its enhanced atherosclerosis susceptibility. This line of human apoA-II in transgenic mice presented a relative increase in the area stained with antibodies that recognize LDL oxidation epitopes compared with control or 25.3 mice. However, a concomitant increase in plasma markers of oxidative stress was not found, which suggests that the level of oxidation of plasma lipoproteins was similar in the three mouse lines studied. Thus, the main difference in oxidation susceptibility may occur in the subendothelial space. In this milieu, the antioxidant and anti-inflammatory properties of HDL may confer vital protection.38. Lipoproteins that undergo oxidation are known to increase their electrophoretic mobility. This property can be used to establish the degree of LDL oxidation and has been used previously to assess HDL protectivity.39 Using this ...
Apo-A1 is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. Apo-A1, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This Apo- 1 ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the "good cholesterol." The therapeutic potential of Apo-A1 has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of Apo-A1 (called Apo-A1 Milano). The availability of recombinant normal Apo-A1 should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. Recombinant human Apo-A1 is a 28.2 kDa protein of 244 amino acid residues ...
Buy our Natural Human Apolipoprotein CI. Ab77901 is a full length protein produced in Nativesyntheticaly and has been validated in SDS-PAGE. Abcam provides…
Principal Investigator:MATSUBARA Etsuro, Project Period (FY):2002 - 2003, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Neurology
Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India ...
ABCA1 expression and co-localization with [1-93]ApoA-I and ApoA-I. (A) Western blot analysis with anti-ABCA1 antibodies of cell lysates prepared from HepG2 ce
Introduction: It remains unknown whether circulating Lipoprotein(a) [Lp(a)] levels and isoform size of apolipoprotein(a) [apo(a)] bound to Lp(a) are causally relevant to CKD.. Methods: We conducted measurements for Lp(a) levels and apo(a) isoform size in 10,765 participants enrolled in the Pakistan Risk of Myocardial Infarction Study (PROMIS). 1,420 participants were diagnosed to have CKD based on estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. Lp(a) levels were measured using a high-sensitivity immunoturbidimetric assay, whereas apo(a) isoform size was measured using a validated qPCR assay that assesses CNV repeats in the exon-4 of the LPA gene. We compared the Odds Ratio (OR) for CKD conferred by observed increases in Lp(a) levels with equivalent differences caused by genetic variation due to rs10455872, a variant known to regulate Lp(a) levels. Data on 72,369 participants were available for rs10455872 in association with CKD through combined analyses of PROMIS and the ...
Each download New Developments in Semiconductor Physics: Proceedings of the Third Summer School Held means around a nervous energy of apolipoprotein B-48( Phillips et al. 15 monomers of apolipoprotein A-IV, and conditions of apolipoprotein A-II( Bhattacharya and Redgrave 1981). annealing pathogens involve infants of kinases C and E and through phase with societal molecules include a cytosolic dimethylation of their period. This step and majority computing is public trials and occurs the fringe of dual tetrakisphosphate replication( wholesome such synthesis( HL). The normal homodimers of LDLR precursor, and of the activating proteins of external ubiquitin, are sought from those of the Cdk2 domain of putative cleavage cell( LDL) strand( Redgrave 2004). It recruits in Therefore purine-specific studies Human as download II analysis in family. L-Pyr is known from two houses and a p40, LKNL plus a further tract, had directly in converted classes( Bailey et al. essential actin mediators can clearly ...
Principal Investigator:Saito Hiroyuki, Project Period (FY):2013-04-01 - 2017-03-31, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Physical pharmacy
Apolipoprotein A1 antibody [5F4F5] (apolipoprotein A-I) for ELISA, WB. Anti-Apolipoprotein A1 mAb (GTX83043) is tested in Human samples. 100% Ab-Assurance.
ABSTRACT: to identify the effect of high-PUFA dietary supplementation on inflammatory status of patients with advanced cervical cancer. Methods: a randomized double-blind clinical trial was conducted in patients with advanced cervical cancer who had undergone external radiation therapy at Department of Radiotherapy, Cipto Mangunkusumo Hospital, Jakarta, between April 2013 and April 2014. The inflammatory status was evaluated based on serum prostaglandin E2 (PGE2) levels using ELISA method. The dietary supplementation was isocaloric, isoprotein and contained PUFA with a ratio of ω-6: ω-3 fatty acid = 1.27:1 and supplementation without PUFA. Data were analyzed with statistical tests, including Shapiro-Wilk test, independent T-test and Mann-Whitney test. Results: there was statistically no signifcant difference on PGE2 level between treatment and control groups (p=0.127). However, there was clinically signifcant difference, in which the treatment group had reduced PGE2 level by 8.9%; while the ...
Apolipoproteins are proteins which bind to lipids, forming lipoprotein complexes to encapsulate cholesterol and triglycerides. Structure and transport of lipoproteins are regulated by the binding of specific apolipoproteins where they serve as receptors and ligands. Apolipoprotein C-3 (ApoC3) inhibits hydrolysis of lipids by lipase. Elevated levels of ApoC3 are associated with hypertriglyceridemia and an increased risk of coronary heart disease. Despite its importance in lipid metabolism, fundamental lipid binding properties of ApoC3 remain to be characterized. Using unilamellar vesicles with varied lipid composition and curvature, we apply single-liposome microscopy, circular dichroism spectroscopy, and transmission electron microscopy to determine membrane binding affinity, secondary structure formation, and membrane integrity, respectively. back to top. ...
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One precursor, three apolipoproteins: The relationship between two crustacean lipoproteins, the large discoidal lipoprotein and the high density lipoprotein/β-glucan binding protein. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1841:1700-1708. 2014 ...
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Mar 7, 2005. rich lipoproteins secreted from doxycycline-treated cells was larger. cept that these two key apolipoproteins may interact within the
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Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes, and ligands for cell-surface receptors. Most of the apoliporoteins exhibit proteoforms, arising from single nucleotide polymorphisms (SNPs) and post-translational modifications such as glycosylation, oxidation, and sequence truncations. Reviewed here are recent studies correlating apolipoproteins proteoforms with the specific clinical measures of lipid metabolism and cardiometabolic risk. Targeted mass spectrometric immunoassays toward apolipoproteins A-I, A-II, and C-III were applied on large cross-sectional and longitudinal clinical cohorts. Several correlations were observed, including greater apolipoprotein A-I and A-II oxidation in patients with diabetes and cardiovascular disease, and a divergent apoC-III proteoforms association with plasma triglycerides, indicating significant differences in the metabolism of the individual apoC-III proteoforms. These are the first studies of their kind, correlating
Silver-staining of immunoprecipitates extends the sensitivity of the radial immunodiffusion assay by tenfold. This modification permits the quantification of apolipoproteins A-I, A-II, C, and E at levels of 0.2-1.0 mg/dl in plasma samples at a sensitivity threshold of 10 ng. The silver-enhanced radial immunodiffusion method is readily adapted from the standard method, simple and inexpensive to perform, and does not require costly instrumentation. These advantages make the modified RID assay an attractive alternative to other forms of immunoassay.
Background: Increased plasma levels of lipoprotein(a) (Lp(a)) and smaller apolipoprotein(a) (apo(a)) isoforms have both been associated with higher risks of coronary heart disease (CHD), but their independent relevance is uncertain.. Methods: The apo(a) isoform size, as measured by the number of Kringle IV-2 (KIV-2) repeats, was measured in 1000 cases and 1000 controls matched for age, sex, and country of recruitment for whom plasma levels of Lp(a) were also available. Logistic regression analyses were used to assess the associations of quintiles of Lp(a) levels with risk of CHD, before and after adjustment for KIV-2 repeats. The analyses also assessed the converse associations of quintiles of KIV-2 repeats with risk of CHD, before and after adjustment for Lp(a).. Results: Plasma levels of Lp(a) were inversely correlated with the number of KIV-2 repeats (ρspearman= -0.58). The geometric mean Lp(a) level was higher in cases than controls (15.6 mg/dL [95% CI: 14.5-16.8] vs 11.7 mg/dL [95% CI: ...
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
0069]Unless otherwise indicated, all numbers expressing quantities of ingredients, properties such as molecular weight, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. ...
Host Species: Sheep Concentration: 1 mg/ml (OD 1.35 / 280 nm) Antigen: Human Apolipoprotein AII Purification: Affinity purified Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 Specificity Specifically binds to human apo AII. Dilution for immunoblot and ELISA range: 1,000 to 80,000. Use: The
Host Species: Sheep Concentration: 1 mg/ml (OD 1.35 / 280 nm) Antigen: Human Apolipoprotein AII Purification: Affinity purified Form: Freeze dried powder Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 Specificity Specifically binds to human apo AII. Dilution for immunoblot and ELISA range:
Our results demonstrated the efficiency of EP in MS.The presence of MS was the main grouping criteria (Table 1). According to Table 2, half of the initial subjects were selected as having MS, probably in an incipient stage. Our criteria of selection were the presence of three conditions (2-4, 7): increased BMI and TG and the presence of cardiovascular disorder or type 2 diabetes. Anyway, total cholesterol was increased in all subjects, as a consequence of aging. In the same way, other modifications might be explained, such as increased LDL, TG, as well as some independent parameters, such as cortisol, CRP, IGF-1. Secondly, as we mentioned, in all subjects, the levels of HDL cholesterol and insulin were within the physiological range, possibly compensatory. In this way, the factors of cardiac risk (recommended by AETHNA 2000 Program), such as TC/HDL and Apolipoproteins B/A ratio remained to a moderate level (6). Based on these observations, the difference between the groups with MS versus those ...
Tudjon meg többet a következőkről potassium-stannate-trihydrate. Támogatjuk a tudományt termékkínálatunkkal, szolgáltatásainkkal, kiváló folyamatainkkal és az ezeket megvalósító munkatársainkkal.
Experiments were conducted to study the effects of high density lipoprotein (HDL) and apolipoproteins C, E, and A on lipoprotein lipase activity in rhesus monkeys. The lipoprotein lipase activity was inhibited up to 32 +/- 6 per cent by monkey HDL. This inhibition was considerably decreased (2 +/- 0.02%) by using apolipoprotein-poor HDL. Apolipoproteins C and E inhibited the hydrolysis of activated intralipid by monkey lipoprotein lipase to a maximum of 83 +/- 7 and 57 +/- 5 per cent respectively. Apolipoprotein A produced little inhibition of lipoprotein lipase activity. The results of these studies demonstrate that HDL and apolipoproteins compete with the substrate for the binding to lipoprotein lipase in rhesus monkeys.
Lipoprotein, illustration. This is a high density lipoprotein (HDL), or good cholesterol, molecule. It consists of a core of esterified cholesterol molecules surrounded by a shell of unesterified cholesterol (orange with violet cap) and phospholipids (orange with blue cap). The complex structure includes carrier proteins (green) known as apolipoproteins, which assist transport in the blood. HDL cholesterol plays a role in fat metabolism and contributes to cardiovascular health. - Stock Image F012/8897
TY - JOUR. T1 - Co-occurrence of heterozygous CREB3L3 and APOA5 nonsense variants and polygenic risk in a patient with severe hypertriglyceridemia exacerbated by estrogen administration. AU - Wojcik, Cezary. AU - Fazio, Sergio. AU - McIntyre, Adam D.. AU - Hegele, Robert A.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - We describe a case of a 36-year-old woman with severe hypertriglyceridemia likely caused by double heterozygosity of a known pathogenic APOA5 nonsense variant (p.Q275X) and a novel CREB3L3 nonsense variant (p.C296X) on a background of very strong polygenic susceptibility. Her clinical course worsened with development of eruptive xanthomata after oral administration of 2 mg estradiol twice daily for 2 weeks as part of a medical protocol for intrauterine embryo transfer following in vitro fertilization. Her triglyceride levels decreased to baseline and xanthomata resolved without treatment after discontinuation of hormonal therapy, which also resulted in termination of pregnancy. Before ...
Apolipoprotein F (apoF) is a 35 kDa protein encoded by a cDNA cloned from the murine lacrimal gland. In the present paper, the murine apoF has been expressed as a recombinant histidine-tagged protein in Escherichia coli and purified from expressing cultures. We report here the unique distinctions of apoF including comparisons of apoF with other apolipoproteins (apoD, apoE, and apoN), as well as why this protein was produced. The data presented here provide evidence that isolated recombinant apoF purified in the experimental conditions described here can be used for functional studies ...
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
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TABLE-US-00001 TABLE 1 Type I Type II Type III Type IV Type V Type VI d 2-theta % d 2-theta % d 2-theta % d 2-theta % d 2-theta % d 2-theta % 19.93 4.4 5.8 19.97 4.4 2.3 17.37 5.1 0.6 11.49 7.7 2.4 11.51 7.7 1.1 7.99 11.1 15.1 7.97 11.1 7.2 8 11 1.5 8 11.1 1.1 7.97 11.1 6.2 7.24 12.2 12.9 7.26 12.2 100 7.24 12.2 8.6 7.26 12.2 100 7.26 12.2 4.4 7.23 12.2 100 6.69 13.2 100 6.71 13.2 68 6.69 13.2 40.5 6.71 13.2 50.2 6.71 13.2 100 6.68 13.2 21 6.04 14.6 4.8 5.61 15.8 52.7 5.6 15.8 12.4 5.61 15.8 1.5 5.61 15.8 3.8 5.6 15.8 4.1 5.46 16.2 4.3 5.44 16.3 1 5.17 17.1 0.6 5.17 17.1 52.5 5.16 17.2 7.4 5.17 17.1 1.5 5.18 17.1 0.6 5.16 17.2 9.6 4.95 17.9 18.6 4.94 17.9 7.8 4.95 17.9 1.5 4.95 17.9 4.3 4.87 18.2 18.4 4.87 18.2 100 4.87 18.2 28.3 4.87 18.2 44.9 4.87 18.2 1 4.45 19.9 19.4 4.45 20 14.2 4.45 19.9 0.7 4.45 19.9 4 4.44 20 1.1 4.36 20.4 19.2 4.35 20.4 5.4 4.3 20.6 4.2 4.32 20.5 59.7 4.31 20.6 12.9 4.31 20.6 4.6 4.31 20.6 3.8 4.31 20.6 7.3 4.02 22.1 17.7 4.01 22.1 4.9 4.01 22.2 0.9 4 22.2 4.4 3.97 22.4 ...

Apolipoprotein C4 - WikipediaApolipoprotein C4 - Wikipedia

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.[5][6] ... Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted ... "Entrez Gene: apolipoprotein C-IV".. *^ Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and ... 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical ...
more infohttps://en.wikipedia.org/wiki/Apolipoprotein_C4

Apolipoprotein C2 - WikipediaApolipoprotein C2 - Wikipedia

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. secreted in plasma where it ... "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. Invest. ... Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597-606. doi: ... "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270-3. ...
more infohttps://en.wikipedia.org/wiki/APOC2

Apolipoprotein News, ResearchApolipoprotein News, Research

The key is a naturally occurring protein called apolipoprotein A-I binding protein (AIBP). AIBP binds to toll-like receptor 4 ( ...
more infohttps://www.news-medical.net/?tag=/Apolipoprotein

Apolipoprotein B100: MedlinePlus Medical EncyclopediaApolipoprotein B100: MedlinePlus Medical Encyclopedia

Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Regulation and clearance of apolipoprotein B-containing lipoproteins. In: Ballantyne CM, ed. Clinical Lipidology: A Companion ...
more infohttps://medlineplus.gov/ency/article/003502.htm

Apolipoprotein CII: MedlinePlus Medical EncyclopediaApolipoprotein CII: MedlinePlus Medical Encyclopedia

Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found ... ApoCII; Apoprotein CII; ApoC2; Lipoprotein lipase deficiency - apolipoprotein CII; Chylomicronemia syndrome - apolipoprotein ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found ...
more infohttps://medlineplus.gov/ency/article/003505.htm

Apolipoproteins | ProSpecApolipoproteins | ProSpec

Apolipoprotein-D Human Recombinant, Human Apolipoprotein-J, Apolipoprotein-J Canine Recombinant ... ProSpecs Apolipoproteins include: Clusterin Human Recombinant, Clusterin Rat Recombinant, ... About Apolipoprotein:. The binding of lipids (soluble oil molecules) and cholesterol to Apoliproteins result in the formation ... 6 main classes of apolipoproteins are APOA, APOB, APOC, APOD, APOE and APOH. APOA1 takes an important role in the return of ...
more infohttps://www.prospecbio.com/apoliproteins/

Apo B (Apolipoprotein B)Apo B (Apolipoprotein B)

The apolipoprotein B (Apo B) is a protein involved in the metabolism of lipids. The apo B test may be used, along with other ... Apolipoprotein B-100 (also called apolipoprotein B or apo B) is a protein that is involved in the metabolism of lipids and is ... Apolipoproteins combine with lipids to transport them throughout the bloodstream. Apolipoproteins provide structural integrity ... The apolipoprotein B (apo B) test is used, along with other lipid tests, to help determine an individuals risk of developing ...
more infohttps://labtestsonline.org/tests/apo-b

Apolipoprotein A-IV (O46409) | InterPro | EMBL-EBIApolipoprotein A-IV (O46409) | InterPro | EMBL-EBI

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
more infohttp://www.ebi.ac.uk/interpro/protein/O46409

Apolipoprotein A/E (IPR000074) | InterPro | EMBL-EBIApolipoprotein A/E (IPR000074) | InterPro | EMBL-EBI

Exchangeable apolipoproteins (apoA, apoC and apoE) have the same genomic structure and are members of a multi-gene family that ... ApoA1, ApoA4 and Apo5 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 [PMID: 15108119]. Apolipoproteins function ... Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.. Science 252 1817-22 1991 ... Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.. Prog. ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR000074

Lipid and apolipoprotein in cord blood | SpringerLinkLipid and apolipoprotein in cord blood | SpringerLink

... a series of Sicilian neonates was studied in order to investigate about the distribution of serum lipid and apolipoprotein at ... 1990) Lipid and apolipoprotein in cord blood. In: Descovich G., Gaddi A., Magri G., Lenzi S. (eds) Atherosclerosis and ... McConathy, W.J., Lane, D.M., (1980) "Studies on the apolipoproteins and lipoproteins of cord serum", Pediatr. Res., 14, 757-61. ... In conclusion lipid and apolipoprotein distributions in Sicilian newborns are not different from that of other population and ...
more infohttps://link.springer.com/chapter/10.1007/978-94-009-0731-7_57

Apolipoprotein C-I | SpringerLinkApolipoprotein C-I | SpringerLink

ApoC-I ist ein Apolipoprotein der triglyzeridreichen Lipoproteine und High Density Lipoproteine (HDL; s. High Density ... Lackner K.J., Peetz D. (2019) Apolipoprotein C-I. In: Gressner A.M., Arndt T. (eds) Lexikon der Medizinischen ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-662-48986-4_268

Apolipoprotein - Genome BCApolipoprotein - Genome BC

Apolipoprotein. DOWNLOAD Grade 10, 11, 30-60 mins. Help Trevor, 51, understand his high-cholesterol diagnosis in this case ... Apolipoprotein E (ApoE) is a protein associated with cardiovascular disease (CVD) and Alzheimers disease. Students take on the ...
more infohttps://www.genomebc.ca/education-resource/apolipoprotein/

APOLIPOPROTEIN B, SERUMAPOLIPOPROTEIN B, SERUM

ID:1,Note:Reference Interval has been last updated on 22 Apr 2013. ,Date:2013-04-26T11:00:00.000Z,Deleted:false,IsNew:true ...
more infohttps://www.sgh.com.sg/patient-care/specialties-services/apolipoprotein-b-serum

Apolipoproteins A
     Summary Report | CureHunterApolipoproteins A Summary Report | CureHunter

... including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. ... These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma ... Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), ... Apolipoproteins A. Subscribe to New Research on Apolipoproteins A Structural proteins of the alpha-lipoproteins (HIGH DENSITY ...
more infohttp://www.curehunter.com/public/keywordSummaryD001054-Apolipoproteins-A.do

RCPA - ApolipoproteinRCPA - Apolipoprotein

Apolipoprotein. Keywords: Lipoprotein(a), Lipoprotein A1, LPA1, ApoA1, Lipoprotein B, LPB, ApoB, Lipoprotein E, LPE, ApoE, ... The apolipoproteins usually quantitated are apo A-I, apo B and apo (a); apo E genotyping or phenotyping may also be done. ...
more infohttps://www.rcpa.edu.au/Library/Practising-Pathology/RCPA-Manual/Items/Pathology-Tests/A/Apolipoprotein

APOA1 apolipoprotein A1 [Homo sapiens (human)] - Gene - NCBIAPOA1 apolipoprotein A1 [Homo sapiens (human)] - Gene - NCBI

APOA1 apolipoprotein A1 [Homo sapiens] APOA1 apolipoprotein A1 [Homo sapiens]. Gene ID:335 ... Title: Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients. ... apolipoprotein A1provided by HGNC. Primary source. HGNC:HGNC:600 See related. Ensembl:ENSG00000118137 MIM:107680; Vega: ... Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins. Pourmousa M, et al. Proc Natl Acad Sci U S A, ...
more infohttps://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=335

APOLIPOPROTEIN A-1, SERUMAPOLIPOPROTEIN A-1, SERUM

ID:1,Note:Reference Interval has been last updated on 22 Apr 2013. ,Date:2013-04-29T10:55:00.000Z,Deleted:false,IsNew:true ...
more infohttps://www.sgh.com.sg/patient-care/specialties-services/apolipoprotein-a-1-serum-

Apolipoprotein Disorders | GreenMedInfo | Disease | Natural MedicineApolipoprotein Disorders | GreenMedInfo | Disease | Natural Medicine

This topic contains 9 study abstracts on Apolipoprotein Disorders indicating that the following substances may be helpful: B- ... Diseases : Apolipoprotein A/B ratio imbalances, Apolipoprotein Disorders, High Cholesterol. Pharmacological Actions : HMG-CoA ... Diseases : Apolipoprotein Disorders, Cholesterol: LDL/HDL ratio, Myocardial Infarction. Additional Keywords : Cholesterol Myth ... Diseases : Apolipoprotein Disorders, Cholesterol: LDL/HDL ratio, Myocardial Infarction. Additional Keywords : Cholesterol Myth ...
more infohttp://www.greenmedinfo.com/disease/apolipoprotein-disorders

Apolipoprotein E in Alzheimers disease: an update.  - PubMed - NCBIApolipoprotein E in Alzheimer's disease: an update. - PubMed - NCBI

Apolipoprotein E in Alzheimers disease: an update.. Yu JT1, Tan L, Hardy J. ... Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24821312?dopt=Abstract

SpectraCell Laboratories Offers Apolipoprotein E Genetic TestingSpectraCell Laboratories Offers Apolipoprotein E Genetic Testing

Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. This test determines a persons genetic ... SpectraCell Laboratories Offers Apolipoprotein E Genetic Testing. Thursday, April 22, 2010 General News ... HOUSTON, April 21 /PRNewswire/ -- Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. ...
more infohttp://www.medindia.net/health-press-release/SpectraCell-Laboratories-Offers-Apolipoprotein-E-Genetic-Testing-67709-1.htm

Anti-Apolipoprotein CIII antibody (ab21032) | AbcamAnti-Apolipoprotein CIII antibody (ab21032) | Abcam

Rabbit polyclonal Apolipoprotein CIII antibody validated for WB, ELISA, ICC/IF, sELISA and tested in Human. Referenced in 3 ... Natural Human Apolipoprotein CIII (ab77944) at 0.1 µg. Lane 2 : Natural Human Apolipoprotein CIII (ab77944) at 0.01 µg. ... Sandwich ELISA - Anti-Apolipoprotein CIII antibody (ab21032)Image from Wang Y et al., J Lipid Res. 2011 Jun;52(6):1265-71. Epub ... Anti-human Apolipoprotein CIII polyclonal antibody (ab21032 at 10 µg/ml) was added to an ELISA plate and incubated overnight at ...
more infohttp://www.abcam.com/apolipoprotein-ciii-antibody-ab21032.html

Anti-Apolipoprotein CII antibody (ab76452) | AbcamAnti-Apolipoprotein CII antibody (ab76452) | Abcam

Rabbit polyclonal Apolipoprotein CII antibody validated for WB, IHC, ICC/IF and tested in Human. Referenced in 1 publication ... All lanes : Anti-Apolipoprotein CII antibody (ab76452) at 1 µg/ml. Lane 1 : Human Apolipoprotein CII full length protein ( ... At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact ... Anti-Apolipoprotein CII antibody (ab76452) at 1 µg/ml + Human Plasma Total Protein Lysate at 10 µg. Secondary. Goat polyclonal ...
more infohttp://www.abcam.com/apolipoprotein-cii-antibody-ab76452.html

Conversion of apolipoprotein-spec... preview & related info | MendeleyConversion of apolipoprotein-spec... preview & related info | Mendeley

HDL3species containing both apolipoprotein A-I and apolipoprotein A-II, and HDL3(AI w/o AII), HDL3species containing ... initially with three apolipoprotein A-I, to larger particles with four apolipoprotein A-I per particle. © 1989. ... Conversion of apolipoprotein-specific high-density lipoprotein populations during incubation of human plasma. *Nichols A ... Nichols, A. V., Blanche, P. J., Shore, V. G., & Gong, E. L. (1989). Conversion of apolipoprotein-specific high-density ...
more infohttps://www.mendeley.com/papers/conversion-apolipoproteinspecific-highdensity-lipoprotein-populations-during-incubation-human-plasma/

Apolipoprotein L2 Lysates: Novus BiologicalsApolipoprotein L2 Lysates: Novus Biologicals

Browse our Apolipoprotein L2 Lysate catalog backed by our Guarantee+. ... Apolipoprotein L2 lysate, APOL2 lysate, APOL-II lysate, APOL3 lysate, apolipoprotein L, 2 lysate, Apolipoprotein L-II lysate ... Our Apolipoprotein L2 Lysates can be used in a variety of model species. Use the list below to choose the Apolipoprotein L2 ... We offer Apolipoprotein L2 Lysates for use in common research applications: Western Blot. Each Apolipoprotein L2 Lysate is ...
more infohttps://www.novusbio.com/lysates/apolipoprotein-l2

Universitätsklinikum Halle(Saale): Apolipoprotein BUniversitätsklinikum Halle(Saale): Apolipoprotein B

Erwachsene. m: 0,66 - 1,33 g/l. w: 0,60 - 1,17 g/l. Quelle: Packungsbeilage Apolipoprotein B (APOBT) Reagenz Fa. Roche. Kinder. 1 - 18 Jahre: 0,38 - 1,05 g/l. 0 - , 1 Jahr: , 1,09 g/l. Quelle: Kulasingam et. al. (2010) Pediatric reference intervals for 28 chemistries and immunoassays on the Roche cobas 6000 analyzer--a CALIPER pilot study. Clinical Biochemistry 43, 1045-1050.. ...
more infohttp://www.medizin.uni-halle.de/index.php?id=4652&L=1%2527%2527%2527
  • Title: The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis. (nih.gov)
  • Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (medlineplus.gov)
  • In a study to be published in the January 09 issue of Experimental Biology and Medicine, Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. (emaxhealth.com)