Apolipoprotein c i. Medical search

A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.

A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).

A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

An inhibitory subclass of NK cell lectin-like receptors that interacts with CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS and prevents the activation of NK CELLS.

Structurally-related receptors that are typically found on NATURAL KILLER CELLS. They are considered lectin-like proteins in that they share sequence homology with the carbohydrate binding domains of C-TYPE LECTINS. They differ from classical C-type lectins, however, in that they appear to lack CALCIUM-binding domains.

A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.

A 513-kDa protein synthesized in the LIVER. It serves as the major structural protein of low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). It is the ligand for the LDL receptor (RECEPTORS, LDL) that promotes cellular binding and internalization of LDL particles.

A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes.

Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.

The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.

Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.

A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.

Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.

A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.

One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.

Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.

A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.

A glycoprotein component of HIGH-DENSITY LIPOPROTEINS that transports small hydrophobic ligands including CHOLESTEROL and STEROLS. It occurs in the macromolecular complex with LECITHIN CHOLESTEROL ACYLTRANSFERASE. Apo D is expressed in and secreted from a variety of tissues such as liver, placenta, brain tissue and others.

A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.

A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.

Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.

Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor. (1/107)

We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that APOC1 overexpression in transgenic mice inhibited the hepatic uptake of VLDL via the LDLR-related protein. In the present study, we have now examined the effect of apoC1 on the binding of lipoproteins to both the VLDL receptor (VLDLR) and the LDLR. The binding specificity of the VLDLR and LDLR for apoC1-enriched lipoprotein particles was examined in vivo through adenovirus-mediated gene transfer of the VLDLR and the LDLR [giving rise to adenovirus-containing (Ad)-VLDLR and Ad-LDLR respectively] in APOC1 transgenic mice, LDLR-deficient (LDLR-/-) mice and wild-type mice. Remarkably, Ad-VLDLR treatment did not reduce hyperlipidaemia in transgenic mice overexpressing human APOC1, irrespective of both the level of transgenic expression and the presence of the LDLR, whereas Ad-VLDLR treatment did reverse hyperlipidaemia in LDLR-/- and wild-type mice. On the other hand, Ad-LDLR treatment strongly decreased plasma lipid levels in these APOC1 transgenic mice. These results suggest that apoC1 inhibits the clearance of lipoprotein particles via the VLDLR, but not via the LDLR. This hypothesis is corroborated by in vitro binding studies. Chinese hamster ovary (CHO) cells expressing the VLDLR (CHO-VLDLR) or LDLR (CHO-LDLR) bound less APOC1 transgenic VLDL than wild-type VLDL. Intriguingly, however, enrichment with apoE enhanced dose-dependently the binding of wild-type VLDL to CHO-VLDLR cells (up to 5-fold), whereas apoE did not enhance the binding of APOC1 transgenic VLDL to these cells. In contrast, for binding to CHO-LDLR cells, both wild-type and APOC1 transgenic VLDL were stimulated upon enrichment with apoE. From these studies, we conclude that apoC1 specifically inhibits the apoE-mediated binding of triacylglycerol-rich lipoprotein particles to the VLDLR, whereas apoC1-enriched lipoproteins can still bind to the LDLR. The variability in specificity of these lipoprotein receptors for apoC1-containing lipoprotein particles provides further evidence for a regulatory role of apoC1 in the delivery of lipoprotein constituents to different tissues on which these receptors are located. (+info)

Mass spectral study of polymorphism of the apolipoproteins of very low density lipoprotein. (2/107)

New isoforms of apolipoprotein (apo)C-I and apoC-III have been detected in delipidated fractions from very low density lipoprotein (VLDL) using matrix-assisted laser desorption (MALDI) and electrospray ionization (ESI) mass spectrometry (MS). The cleavage sites of truncated apoC-III isoforms have also been identified. The VLDL fractions were isolated by fixed-angle single-spin ultracentrifugation using a self-generating sucrose density gradient and delipidated using a newly developed C18 solid phase extraction protocol. Fifteen apoC isoforms and apoE were identified in the MALDI spectra and the existence of the more abundant species was verified by ESI-MS. The relative intensities of the apoCs are closely correlated in three normolipidemic subjects. A fourth subject with type V hyperlipidemia exhibited an elevated apoC-III level and a suppressed level of the newly discovered truncated apoC-I isoform. ApoC-II was found to be particularly sensitive to in vitro oxidation. The dynamic range and specificity of the MALDI assay shows that the complete apoC isoform profile and apoE phenotype can be obtained in a single measurement from the delipidated VLDL fraction. (+info)

Protective effect of apolipoprotein A I, A II, C I and C II on endothelial cells injury induced by low density lipoprotein. (3/107)

OBJECTIVE: To investigate the protective effect of apo-lipoprotein (apo) A I, A II, C I and C II, the main proteins in high density lipoprotein (HDL), on the morphology and function of human umbilical vein endothelial cells injured with low density lipoprotein (LDL) in vitro. METHODS: Cultured human endothelial cells derived from umbilical veins were exposed to LDL, HDL, and apoA I, A II, C I and C II. The morphology of endothelial cells was examined with phase contrast and transmission electron microscope. The released amount of lactate dehydrogenase (LDH) and 6-keto-prostaglandin F1 alpha (PGF1 alpha) was also measured. RESULTS: Endothelial cells after being injured by LDL showed cell contraction, increased release of LDH and decreased secrection of prostacyclin (PGI2). However, the addition of HDL, and apoA I, A II, C I and C II before incubation with LDL inhibited the cellular injury induced by LDL as demonstrated by lowered LDH release, increased level of PGF1 alpha and prevention of morphological changes. CONCLUSION: The results indicate that apoA I, A II, C I and C II, as well as HDL, may play an important role in combating atherogenesis by protecting endothelial cells from damages induced by LDL. (+info)

Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide. (4/107)

To test, at the level of individual amino acids, the conformation of an exchangeable apolipoprotein in aqueous solution and in the presence of an osmolyte trimethylamine-N-oxide (TMAO), six synthetic peptide analogues of human apolipoprotein C-1 (apoC-1, 57 residues) containing point mutations in the predicted alpha-helical regions were analyzed by circular dichroism (CD). The CD spectra and the melting curves of the monomeric wild-type and plasma apoC-1 in neutral low-salt solutions superimpose, indicating 31 +/- 4% alpha-helical structure at 22 degrees C that melts reversibly with T(m,WT) = 50 +/- 2 degrees C and van't Hoff enthalpy deltaH(v,WT)(Tm) = 18 +/- 2 kcal/mol. G15A substitution leads to an increased alpha-helical content of 42 +/- 4% and an increased T(m,G15A) = 57 +/- 2 degrees C, which corresponds to stabilization by delta deltaG(app) = +0.4 +/- 1.5 kcal/mol. G15P mutant has approximately 20% alpha-helical content at 22 degrees C and unfolds with low cooperativity upon heating to 90 degrees C. R23P and T45P mutants are fully unfolded at 0-90 degrees C. In contrast, Q31P mutation leads to no destabilization or unfolding. Consequently, the R23 and T45 locations are essential for the stability of the cooperative alpha-helical unit in apoC-1 monomer, G15 is peripheral to it, and Q31 is located in a nonhelical linker region. Our results suggest that Pro mutagenesis coupled with CD provides a tool for assigning the secondary structure to protein groups, which should be useful for other self-associating proteins that are not amenable to NMR structural analysis in aqueous solution. TMAO induces a reversible cooperative coil-to-helix transition in apoC-1, with the maximal alpha-helical content reaching 74%. Comparison with the maximal alpha-helical content of 73% observed in lipid-bound apoC-1 suggests that the TMAO-stabilized secondary structure resembles the functional lipid-bound apolipoprotein conformation. (+info)

Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease. (5/107)

BACKGROUND: Exaggerated postprandial triglyceridemia is common in normolipidemic patients with coronary artery disease (CAD). Alterations in the composition of triglyceride-rich lipoproteins (TRLs) are likely to underlie this metabolic disturbance. However, the composition of very-low-density lipoproteins (VLDLs), which are the most abundant postprandial TRLs, has never been defined in CAD patients. METHODS AND RESULTS: We examined postprandial changes in the number and composition of VLDLs in middle-aged, normolipidemic CAD patients and control subjects. TRLs from 14 patients and 14 control subjects aged 45 to 55 years were subfractionated by density gradient ultracentrifugation into Svedberg flotation rate (Sf) fractions >400, 60 to 400, and 20 to 60. The VLDLs were separated from chylomicron remnants by immunoaffinity chromatography. In CAD patients, the postprandial concentrations of triglycerides and large (Sf 60 to 400) VLDL particles were elevated. In addition, their postprandial large VLDLs were enriched in apolipoprotein (apo) C-I and their postprandial small (Sf 20 to 60) VLDL remnants were enriched with apo C-I and cholesterol. CONCLUSIONS: Perturbed handling of postprandial triglycerides in normolipidemic CAD patients involves the accumulation of apo C-I-rich large VLDL particles and the generation of small, apo C-I- and cholesterol-rich VLDL remnants. (+info)

Structural studies of a baboon (Papio sp.) plasma protein inhibitor of cholesteryl ester transferase. (6/107)

A 38-residue protein associated with cholesteryl ester transfer inhibition has been identified in baboons (Papio sp.). The cholesteryl ester transfer inhibitor protein (CETIP) corresponds to the N-terminus of baboon apoC-I. Relative to CETIP, baboon apoC-I is a weak inhibitor of baboon cholesteryl ester transferase (CET). To study the structural features responsible for CET inhibition, CETIP was synthesized by solid-phase methods. Using sodium dodecyl sulfate (SDS) to model the lipoprotein environment, the solution structure of CETIP was probed by optical and 1H NMR spectroscopy. Circular dichroism data show that the protein lacks a well-defined structure in water but, upon the addition of SDS, becomes helical (56%). A small blue shift of 8 nm was observed in the intrinsic tryptophan fluorescence of CETIP in the presence of saturating amounts of SDS, suggesting that tryptophan-23 is not buried deeply in the lipid environment. The helical nature of CETIP in the presence of SDS was confirmed by upfield 1Halpha secondary shifts and an average solution structure determined by distance geometry/simulated annealing calculations using 476 NOE-based distance restraints. The backbone (N-Calpha-C=O) root-mean-square deviation of an ensemble of 17 out of 25 calculated structures superimposed on the average structure was 1.06+0.30 A using residues V4-P35 and 0.51+/-0.17 A using residues A7-S32. Although the side-chain orientations fit the basic description of a class A amphipathic helix, both intramolecular salt bridge formation and "snorkeling" of basic side chains toward the polar face play minor, if any, roles in stabilizing the lipid-bound amphipathic structure. Conformational features of the calculated structures for CETIP are discussed relative to models of CETIP inhibition of cholesteryl ester transferase. (+info)

Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. (7/107)

The aim of the present study was to identify the protein that accounts for the cholesteryl ester transfer protein (CETP)-inhibitory activity that is specifically associated with human plasma high density lipoproteins (HDL). To this end, human HDL apolipoproteins were fractionated by preparative polyacrylamide gradient gel electrophoresis, and 30 distinct protein fractions with molecular masses ranging from 80 down to 2 kDa were tested for their ability to inhibit CETP activity. One single apolipoprotein fraction was able to completely inhibit CETP activity. The N-terminal sequence of the 6-kDa protein inhibitor matched the N-terminal sequence of human apoC-I, the inhibition was completely blocked by specific anti-apolipoprotein C-I antibodies, and mass spectrometry analysis confirmed the identity of the isolated inhibitor with full-length human apoC-I. Pure apoC-I was able to abolish CETP activity in a concentration-dependent manner and with a high efficiency (IC(50) = 100 nmol/liter). The inhibitory potency of total delipidated HDL apolipoproteins completely disappeared after a treatment with anti-apolipoprotein C-I antibodies, and the apoC-I deprivation of native plasma HDL by immunoaffinity chromatography produced a mean 43% rise in cholesteryl ester transfer rates. The main localization of apoC-I in HDL and not in low density lipoprotein in normolipidemic plasma provides further support for the specific property of HDL in inhibiting CETP activity. (+info)

Long terminal repeats are used as alternative promoters for the endothelin B receptor and apolipoprotein C-I genes in humans. (8/107)

To examine the potential regulatory involvement of retroelements in the human genome, we screened the transcribed sequences of GenBank and expressed sequence tag data bases with long terminal repeat (LTR) elements derived from different human endogenous retroviruses. These screenings detected human transcripts containing LTRs belonging to the human endogenous retrovirus-E family fused to the apolipoprotein CI (apoC-I) and the endothelin B receptor (EBR) genes. However, both genes are known to have non-LTR (native) promoters. Initial reverse transcription-polymerase chain reaction experiments confirmed and authenticated the presence of transcripts from both the native and LTR promoters. Using a 5'-rapid amplification of cDNA ends protocol, we showed that the alternative transcripts of apoC-I and EBR are initiated and promoted by the LTRs. The LTR-apoC-I fusion and native apoC-I transcripts are present in many of the tissues tested. As expected, we found apoC-I preferentially expressed in liver, where about 15% of the transcripts are derived from the LTR promoter. Transient transfections suggest that the expression is not dependent on the LTR itself, but the presence of the LTR increases activity of the apoC-I promoter from both humans and baboons. The native EBR-driven transcripts were also detected in many tissues, whereas the LTR-driven transcripts appear limited to placenta. In contrast to the LTR of apoC-I, the EBR LTR promotes a significant proportion of the total EBR transcripts, and transient transfection results indicate that the LTR acts as a strong promoter and enhancer in a placental cell line. This investigation reports two examples where LTR sequences contribute to increased transcription of human genes and illustrates the impact of mobile elements on gene and genome evolution. (+info)

... D Apolipoprotein E Apolipoprotein F Apolipoprotein H - a misnomer Apolipoprotein L Apolipoprotein M ... Apolipoprotein A (Apo-AI, Apo-A2, Apo-A4, and Apo-A5) Apolipoprotein B (Apo-B48 and Apo B-100) Apolipoprotein C (ApoC-I, apo ... Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to ... Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet. Apolipoprotein synthesis in ...

https://en.wikipedia.org/wiki/Apolipoprotein

... is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different ... APOL1 is a member of a family of apolipoproteins which also includes six other proteins and it is a member of bcl2 genes which ... G2 is an in-frame deletion of the two amino acid residues, N388 and Y389.[citation needed] Apolipoprotein L1 (apoL1) is a minor ... particles that also contain apolipoprotein A1 (APOA1) and the hemoglobin-binding, haptoglobin-related protein (HPR). The APOL1 ...

https://en.wikipedia.org/wiki/Apolipoprotein_L1

Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I". The Journal of Biological ... Apolipoprotein D (ApoD) is a component of HDL that has no marked similarity to other apolipoprotein sequences. It has a high ... "Entrez Gene: APOD apolipoprotein D". Muffat J, Walker DW (January 2010). "Apolipoprotein D: an overview of its role in aging ... Apolipoproteins+D at the US National Library of Medicine Medical Subject Headings (MeSH) Applied Research on Apolipoproteins ...

https://en.wikipedia.org/wiki/Apolipoprotein_D

Apolipoprotein+H at the US National Library of Medicine Medical Subject Headings (MeSH) Apolipoprotein H and Applied Research ... The first four domains found in Apolipoprotein H resemble each other, however the fifth one appears to be different. This ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Apolipoprotein H (B2G1) (Articles ... β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein ...

https://en.wikipedia.org/wiki/Apolipoprotein_H

The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). The ... "Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of ... Apolipoprotein E (APOE) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in ... Apolipoprotein E enhances proteolytic break-down of this peptide, both within and between cells. The isoform APOE-ε4 is not as ...

https://en.wikipedia.org/wiki/Apolipoprotein_E

... (ApoB) is a protein that in humans is encoded by the APOB gene. Apolipoprotein B is the primary apolipoprotein ... Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, Adeli K (2009). "Apolipoprotein B100 acts as a molecular link between lipid- ... MedlinePlus Encyclopedia: Apolipoprotein B100 Cromwell WC, Otvos JD, Keyes MJ, Pencina MJ, Sullivan L, Vasan RS, Wilson PW, ... Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver ...

https://en.wikipedia.org/wiki/Apolipoprotein_B

... (ApoA-I) is a protein that in humans is encoded by the APOA1 gene. As the major component of HDL particles, ... The encoded apolipoprotein A-I, is a 28.1 kDa protein composed of 243 amino acids; 21 peptides have been observed through mass ... Apolipoprotein AI has also been isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect ... Apolipoprotein AI is the major protein component of high density lipoprotein (HDL) particles in plasma. Chylomicrons secreted ...

https://en.wikipedia.org/wiki/Apolipoprotein_AI

... (Apo L) is found in high-density lipoprotein complexes that plays a central role in cholesterol transport. The ... reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for ...

https://en.wikipedia.org/wiki/Apolipoprotein_L

In the field of molecular biology, apolipoprotein C is a family of four low molecular weight apolipoproteins, designated as C-I ... In the fasting state, the C apolipoproteins are mainly associated with HDL. During absorption of dietary fat, the C ... v t e (Articles with short description, Short description matches Wikidata, Apolipoproteins, All stub articles, Protein stubs) ... Mahley RW, Innerarity TL, Rall SC, Weisgraber KH (December 1984). "Plasma lipoproteins: apolipoprotein structure and function ...

https://en.wikipedia.org/wiki/Apolipoprotein_C

... is the first chondroitine sulphate chain containing apolipoprotein. Apolipoproteins are proteins that binds to ... APOO is a member of the apolipoprotein family. The human, apolipoprotein O is a 198 amino acids protein that contains a 23 ... Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. ... 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. ...

https://en.wikipedia.org/wiki/Apolipoprotein_O

... (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The ... 1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. ... Connelly PW, Maguire GF, Little JA (1988). "Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated ... "Entrez Gene: APOC2 apolipoprotein C-II". Jackson RL, Baker HN, Gilliam EB, Gotto AM (1977). "Primary structure of very low ...

https://en.wikipedia.org/wiki/Apolipoprotein_C-II

... , also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene. APOC4 is a ... "Entrez Gene: apolipoprotein C-IV". Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization ... 2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex ... 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical ...

https://en.wikipedia.org/wiki/Apolipoprotein_C-IV

... is an autosomal dominant disorder resulting from a missense mutation which reduces the affinity of ...

https://en.wikipedia.org/wiki/Apolipoprotein_B_deficiency

In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a ...

https://en.wikipedia.org/wiki/Anti-apolipoprotein_antibodies

... also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. ... Karathanasis SK (Oct 1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV ... Apolipoprotein+C-III at the US National Library of Medicine Medical Subject Headings (MeSH) Human APOC3 genome location and ... Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK (Jul 1985). "Distribution of apolipoprotein A-I, C-II, C-III, and E ...

https://en.wikipedia.org/wiki/Apolipoprotein_C-III

Myklebost O, Rogne S (August 1986). "The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein ... "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene". The Journal of Biological ... Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene. The protein encoded by ... "Entrez Gene: APOC1 apolipoprotein C-I". Puppione DL, Ryan CM, Bassilian S, Souda P, Xiao X, Ryder OA, Whitelegge JP (March 2010 ...

https://en.wikipedia.org/wiki/Apolipoprotein_C-I

... is a protein that in humans is encoded by the APOA2 gene. APOA2 encodes apolipoprotein A-II, (ApoA-II) ... "Entrez Gene: APOA2 apolipoprotein A-II". Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998 ... Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein ... The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result ...

https://en.wikipedia.org/wiki/Apolipoprotein_A-II

The apolipoprotein B (apoB) 5′ UTR cis regulatory element is an RNA element located in the 5′ UTR of the human apoB mRNA. This ... Page for Apolipoprotein B (apoB) 5′ UTR cis-regulatory element at Rfam v t e (Articles with short description, Short ... Pontrelli L, Sidiropoulos KG, Adeli K (June 2004). "Translational control of apolipoprotein B mRNA: regulation via cis elements ...

https://en.wikipedia.org/wiki/Apolipoprotein_B_(apoB)_5′_UTR_cis-regulatory_element

... apolipoprotein D; beta-lactoglobulin; complement component C8 gamma chain; crustacyanin; epididymal-retinoic acid binding ...

https://en.wikipedia.org/wiki/Lipocalin

Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 ... Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR (25 February 1983). "Apolipoprotein A-IMilano. ...

https://en.wikipedia.org/wiki/ApoA-1_Milano

Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (Jun 1996). "Human apolipoprotein E ... Apolipoprotein E (ApoE) plays an important role in phospholipid and cholesterol homeostasis. After binding ApoER2, ApoE is ... Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the ... Herz J (June 2009). "Apolipoprotein E receptors in the nervous system". Curr. Opin. Lipidol. 20 (3): 190-6. doi:10.1097/MOL. ...

https://en.wikipedia.org/wiki/Low-density_lipoprotein_receptor-related_protein_8

Apolipoprotein M is a protein that in humans is encoded by the APOM gene. The protein encoded by this gene is an apolipoprotein ... "Entrez Gene: APOM apolipoprotein M". Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes ... Overview of all the structural information available in the PDB for UniProt: O95445 (Human Apolipoprotein M) at the PDBe-KB. v ... 2004). "Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is ...

https://en.wikipedia.org/wiki/APOM

Xu, Ning; Dahlbäck, Björn (1999). "A Novel Human Apolipoprotein (ApoM)". Journal of Biological Chemistry. 274 (44): 31286-31290 ... "Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M". Proceedings of the National ...

https://en.wikipedia.org/wiki/Björn_Dahlbäck

1996). Apolipoprotein E and Alzheimer's Disease. Research and Perspectives in Alzheimer's Disease. Berlin, Heidelberg: Springer ... "Maestre CV" (PDF). Maestre, Gladys Elena (1996). Apolipoproteins and Alzheimer's disease (Thesis). OCLC 36257436. Staff, M. D. ... "The apolipoprotein ?4 allele in patients with Alzheimer's disease". Annals of Neurology. 34 (5): 752-754. doi:10.1002/ana. ... "Apolipoprotein E and alzheimer's disease: Ethnic variation in genotypic risks". Annals of Neurology. 37 (2): 254-259. doi: ...

https://en.wikipedia.org/wiki/Gladys_Maestre

"Entrez Gene: APOL3 apolipoprotein L, 3". Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, et al. (2021). "A human ... Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. Expressed in the gut, it has antibiotic properties ... This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect ... Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP (April 2001). "Apolipoprotein L gene family: tissue-specific expression, ...

https://en.wikipedia.org/wiki/APOL3

Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. ... Alzheimer's disease and apolipoprotein E (apoE). Uncovered the molecular pathways that link apoE and Alzheimer's disease, and ...

https://en.wikipedia.org/wiki/Gladstone_Institutes

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL2 apolipoprotein L, 2". "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2". Liao W, Goh FY, Betts RJ, ... "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2". Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant ... "Nextprot Gene: APOL2 apolipoprotein L, 2". Luo, Audrey; Jung, Jeesun; Longley, Martha; Rosoff, Daniel B.; Charlet, Katrin; ...

https://en.wikipedia.org/wiki/APOL2

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL6 apolipoprotein L, 6". Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser. ... Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, ... Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, ...

https://en.wikipedia.org/wiki/APOL6

The HDL donates apolipoprotein C-II (APOC2) and apolipoprotein E (APOE) to the nascent chylomicron and, thus, converts it to a ... The main apolipoprotein component is ApoB48. While circulating in blood, chylomicrons exchange components with high-density ... Apolipoproteins are significant in the synthesis and metabolism of chylomicrons. Newly formed chylomicrons are secreted through ... The triglycerides are then combined with phospholipids, cholesteryl esters, and apolipoprotein B48 (ApoB48) to form a nascent ...

https://en.wikipedia.org/wiki/Chylomicron

2003). "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. ...

https://en.wikipedia.org/wiki/Bleomycin_hydrolase

Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Regulation and clearance of apolipoprotein B-containing lipoproteins. In: Ballantyne CM, ed. Clinical Lipidology: A Companion ...

https://medlineplus.gov/ency/article/003502.htm

LBXAPB - Apolipoprotein (B) (mg/dL). Variable Name: LBXAPB. SAS Label: Apolipoprotein (B) (mg/dL). English Text: Apolipoprotein ... LBDAPBSI - Apolipoprotein (B) (g/L). Variable Name: LBDAPBSI. SAS Label: Apolipoprotein (B) (g/L). English Text: Apolipoprotein ... Apolipoprotein B (ApoB_G) Data File: ApoB_G.xpt First Published: January 2014. Last Revised: NA ... Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. ...

https://wwwn.cdc.gov/Nchs/Nhanes/2011-2012/APOB_G.htm

Beta apolipoproteins. Beta apolipoproteins are the largest of the apolipoproteins. They are critically important for the ... Apolipoprotein B-100 deficiency. Intestinal steatosis despite apolipoprotein B-48 synthesis. J Clin Invest. 1985 Aug. 76(2):403 ... CMs, VLDL, and LDL carry apolipoproteins on their surface; these apolipoproteins have lipid-soluble segments, the beta ... The 2 beta apolipoproteins are B-100 and B-48. ApoB-100 is carried on VLDL and the lipoproteins derived from its metabolism, ...

https://www.medscape.com/answers/121975-192193/what-is-the-role-of-beta-apolipoproteins-in-the-pathophysiology-of-abetalipoproteinemia-abl

Mouse Apolipoprotein M (APOM) ELISA kit from Cusabio. Cat#: CSB-EL001947MO. US, UK & Europe Distribution. Online Order or ... Mouse Apolipoprotein M (APOM) ELISA kit , CSB-EL001947MO Cusabio Elisa Mouse Apolipoprotein M (APOM) ELISA kit , CSB-EL001947MO ... Rat Apolipoprotein M (APOM) ELISA kit , CSB-EL001947RA , CusabioRat Apolipoprotein M (APOM) ELISA kit is Available at Gentaur ... Human Apolipoprotein M (APOM) ELISA kit , CSB-EL001947HU , CusabioHuman Apolipoprotein M (APOM) ELISA kit is Available at ...

https://joplink.net/mouse-apolipoprotein-m-apom-elisa-kit-csb-el001947mo/

Apolipoprotein (apo) E4 is a risk factor for heart disease, Alzheimers disease, and other forms of neurodegeneration, but the ... Effect of domain interaction on apolipoprotein E levels in mouse brain J Neurosci. 2005 Nov 16;25(46):10658-63. doi: 10.1523/ ... Apolipoprotein (apo) E4 is a risk factor for heart disease, Alzheimers disease, and other forms of neurodegeneration, but the ...

https://pubmed.ncbi.nlm.nih.gov/16291938/

Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey ...

https://extranet.who.int/iris/restricted/browse?authority=Apolipoproteins+B&type=mesh

Rabbit polyclonal Apolipoprotein A I antibody. Validated in WB, ICC/IF, sELISA and tested in Human. Cited in 8 publication(s). ... Anti-Apolipoprotein A I antibody. See all Apolipoprotein A I primary antibodies. ... to Apolipoprotein A I (ab20918) at 1ug/ml and Detector Antibody Rabbit polyclonal to Apolipoprotein A I (ab64308) at 0.5ug/ml ... Recombinant Human Apolipoprotein A I (ab50239) can be used as a positive control in WB. This antibody gave a positive signal in ...

https://www.abcam.com/apolipoprotein-a-i-antibody-ab64308.html?productWallTab=Abreviews

apolipoprotein B mRNA editing enzyme catalytic subunit 3Bprovided by HGNC. Primary source. HGNC:HGNC:17352 See related. Ensembl ... APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B [ Homo sapiens (human) ] Gene ID: 9582, updated on 4-Dec- ... Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis. ... Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis. ...

https://www.ncbi.nlm.nih.gov/gene/9582

In this way, apolipoprotein A can help to lower your risk for cardiovascular disease. Apolipoprotein A levels can be measured. ... Apolipoprotein A. Does this test have other names?. Apo A-1, apolipoprotein a-1 ... The accuracy of your heart disease risk is better when both apolipoprotein A and apolipoprotein B levels are measured and ... Apolipoprotein A is a protein carried in HDL ("good") cholesterol. It helps start the process for HDL to remove bad types of ...

https://www.ahealthyme.com/YourFamily/OlderAdults/Tools/167,apolipoprotein_a

Apolipoprotein B, Human Plasma at Fishersci.com ...

https://www.fishersci.com/shop/products/apolipoprotein-b-human-plasma/AAJ66463EXD

Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been ... while apolipoprotein particles were measured by the department of laboratory. ,i,Results,/i,. The plasma concentration of Lp- ... levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. ... denoting the communication between Lp-PLA2 and apolipoprotein particles in the state of CAD. ...

https://www.hindawi.com/journals/dm/2020/8818358/

Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Apolipoproteins E, Cohort Studies, Female, Genotype, Humans, Male ... Importance: The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger ... Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.. ...

https://www.broadinstitute.org/publications/broad510811

Although apolipoprotein E polymorphism ε4 allele (ApoE4) and slow gait are well-known risk factors for cognitive impairment, ... Although apolipoprotein E polymorphism ε4 allele (ApoE4) and slow gait are well-known risk factors for cognitive impairment, ... Overlap Between Apolipoprotein Eε4 Allele and Slowing Gait Results in Cognitive Impairment. Ryota Sakurai1,2*, Yutaka Watanabe3 ... Apolipoprotein E polymorphism ε4 allele (ApoE4) is associated with cognitive impairment (Farrer et al., 1997; Liu et al., 2013 ...

https://www.frontiersin.org/articles/10.3389/fnagi.2019.00247/full

Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3, APOAV. ... but at much lower concentration than other apolipoproteins. ...

https://www.prospecbio.com/apoa5_human

Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are ... Saura, J., Petegnief, V., Wu, X., Liang, Y. and Paul, S.M. (2003) Microglial Apolipoprotein E and Astroglial Apolipoprotein J ... Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are ... LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis () ...

https://www.scirp.org/journal/paperinformation.aspx?paperid=55147

... and by the apolipoprotein E4 (apoE4) isoform of apoE, the major apolipoprotein in the nervous system (Nathan et al., 1994; ... 1994) Apolipoprotein E in animal models of CNS injury and in Alzheimers disease. Trends Neurosci 17:525-530. ... 2000) Apolipoprotein E and neuromuscular disease: a critical review of the literature. Arch Neurol 57:1561-1565. ... 1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial ...

https://www.jneurosci.org/content/28/31/7891

Rabbit Polyclonal Apolipoprotein B antibody. Validated in ICC/IF. Tested in Human, Rat. ... There are currently no references for Apolipoprotein B antibody (GTX64377). Be the first to share your publications with this ... There are currently no reviews for Apolipoprotein B antibody (GTX64377). Be the first to share your experience with this ... This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main ...

https://www.genetex.com/Product/Detail/Apolipoprotein-B-antibody/GTX64377

Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis ... Levels of apolipoprotein A-I (apoA-I) have been found to be reduced in the lungs of patients with IPF, while administration of ... clinical phenotyping and genotyping protocol that will assess whether holo-apoA-I and apolipoprotein A-I mimetic peptides, can ...

https://www.centerwatch.com/clinical-trials/listings/218176/characterization-of-apolipoprotein-a-i-pathways-in-idiopathic-pulmonary-fibrosis/?q=idiopathic+pulmonary+fibrosis&query=idiopathic%20pulmonary%20fibrosis&featured=true&rnk=3

Apolipoprotein E binds avidly to beta amyloid (A beta) peptide, a major component of senile plaque of Alzheimers disease, in ... Apolipoprotein E associates with beta amyloid peptide of Alzheimers disease to form novel monofibrils. Isoform apoE4 ... Late-onset and sporadic Alzheimers disease are associated with the apolipoprotein E (apoE) type 4 allele expressing the ...

https://www.jci.org/articles/view/117407

Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 … ... Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele. . ... Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele ... Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele. NeuroImage, 222, ...

https://www.waisman.wisc.edu/publications/longitudinal-white-matter-and-cognitive-development-in-pediatric-carriers-of-the-apolipoprotein-%CE%B54-allele/

apolipoprotein E (ApoE), atherosclerosis, endothelial nitric oxide synthase (eNOS), inflammation, tetrahydrobiopterin (BH4), ... Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice Tim S. ... apolipoprotein E-knockout) mice. Single oral dose pharmacokinetic studies revealed rapid BH4 uptake into plasma and organs. ... Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice. Clin ...

https://portlandpress.com/clinsci/article-abstract/119/3/131/68719/Tetrahydrobiopterin-supplementation-reduces?redirectedFrom=PDF

Apolipoprotein B) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-05817. USA, UK & Europe Distribution. ... Rat ApoB (Apolipoprotein B) ELISA Kit , G-EC-05817. Rating * Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 stars ... Rat ApoB (Apolipoprotein B) ELISA Kit , G-EC-05817 , Gentaur Elisa Kits ...

https://caslab.com/rat-apob-apolipoprotein-b-elisa-kit-g-ec-05817/

Increased Risk of Sudden Infant Death Syndrome (SIDS) Among Infants Harboring the Apolipoprotein E-4 Allele: Genetic and ...

https://www.aafs.org/research/increased-risk-sudden-infant-death-syndrome-sids-among-infants-harboring-apolipoprotein-e

Associations Among Apolipoprotein A1 Structural Variants and High-Density Lipoprotein Function. *Wilkins, John T (PD/PI) ... HDL particles are composed of apolipoprotein A1 (apoA1) and enzymes embedded in a spherical phospholipid layer that surrounds a ...

https://www.scholars.northwestern.edu/en/projects/associations-among-apolipoprotein-a1-structural-variants-and-high-5

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Publikation: Bidrag til tidsskrift ... Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified ...

https://forskning.ku.dk/soeg/result/?pure=da%2Fpublications%2Fapolipoprotein-m-binds-oxidized-phospholipids-and-increases-the-antioxidant-effect-of-hdl

In apolipoprotein E‑knockout mice, a high‑fat diet reduced miR‑126 expression and induced apoptosis as determined by the ... In the present study, apolipoprotein E (apoE)‑/‑ mice were fed a high‑fat diet in order to establish a model of AS. Mice were ... MicroRNA‑126 inhibits endothelial permeability and apoptosis in apolipoprotein E‑knockout mice fed a high‑fat diet. *Authors: * ... Cheng XW, Wan YF, Zhou Q, Wang Y and Zhu HQ: MicroRNA‑126 inhibits endothelial permeability and apoptosis in apolipoprotein E‑ ...

https://www.spandidos-publications.com/mmr/16/3/3061

Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ...

https://portal.research.lu.se/sv/publications/apolipoprotein-m-induces-inhibition-of-inflammatory-responses-via

Tissue and/or cellular expressions of interleukin-1 alpha (IL-1α), apolipoprotein E (ApoE), amyloid β (Aβ) precursor protein ( ... Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience. Access & Citations. * 5421 Article ...

https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-10-35/metrics

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimers disease. A. M. Saunders, W. J. ... Apolipoprotein E, type ϵ4 allele (APOE ϵ4), is associated with late-onset familial Alzheimers disease (AD). There is high ... Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimers disease ...

https://n.neurology.org/content/43/8/1467?ijkey=b78e7b318bf3d8f5af8f5d547bda75491ebbbf31&keytype2=tf_ipsecsha

Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia. ... Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia. Journal Article (Journal Article ... Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size ...

https://scholars.duke.edu/display/pub715380

Importance: The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. (broadinstitute.org)
Apolipoprotein E (apoE) is a key transporter of the cholesterol and phospholipids required for membrane synthesis and nerve growth. (jneurosci.org)
Late-onset and sporadic Alzheimer's disease are associated with the apolipoprotein E (apoE) type 4 allele expressing the protein isoform apoE4. (jci.org)
We have used a pharmaceutical BH 4 formulation to investigate the effects of BH 4 supplementation on atherosclerosis progression in ApoE-KO (apolipoprotein E-knockout) mice. (portlandpress.com)
In the present study, apolipoprotein E (apoE)‑/‑ mice were fed a high‑fat diet in order to establish a model of AS. (spandidos-publications.com)
Apolipoprotein E, type ϵ4 allele (APOE ϵ4), is associated with late-onset familial Alzheimer's disease (AD). (neurology.org)
Apolipoprotein E-(apoE) deficient mice exhibit hypercholesterolemia, accelerated atherosclerosis and increased infarct size after middle cerebral artery occlusion (MCAO). (duke.edu)
In this context, apolipoprotein E gene ( APOE ) is a key element with a well-established association among their alleles and the neurodegenerative consequences of mercury intoxication. (hugginsappliedhealing.com)
Neuroimaging shows brain-functional differences due to apolipoprotein E (APOE) polymorphisms may exist decades before the increased risk period for Alzheimer's disease, but little is known about their effect on cognition and brain function in children and young adults. (garvan.org.au)
Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories. (ox.ac.uk)
Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the ε4 allele (highest genetic risk factor for Alzheimer's disease) on memory. (ox.ac.uk)
We injected AAV-PHP.eB into the bloodstream of wild-type C57BL/6 and BALB/c mice as well as mouse strains carrying genetic mutation in apolipoprotein E gene ( Apoe ) or low-density lipoprotein receptor gene ( Ldlr ), or lacking various components of the immune system. (thno.org)
The E4 isoform of apolipoprotein E (apoE) has been associated with poor clearance of Aβ under in vitro conditions. (edu.au)
Six apolipoprotein fasting serum concentrations were measured using a Luminex proteomics platform (xMAP Multiplex immunoassay): apolipoprotein A-I (apoAI), apolipoprotein A-II (apoAII), apolipoprotein B (apoB), apolipoprotein C-II (apoCII), apolipoprotein C-III (apoCIII) and apolipoprotein E (apoE). (biomedcentral.com)
Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. (maastrichtuniversity.nl)
Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
Objective: Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein epsilon-4 (APOE-epsilon4) allele. (cdc.gov)
Group allocation was stratified by age, apolipoprotein E (APOE) ε4 allele status, and cholesterol level. (gla.ac.uk)

Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
Increasing evidence states that the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. (hindawi.com)
Xie BS, Wang X, Pan YH, Jiang G, Feng JF, Lin Y. Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice. (thno.org)
Apolipoprotein A1, the protein component of high density lipoprotein (HDL), is an abundant protein in the mammalian cerebrospinal fluid. (imrpress.com)
Apolipoprotein B is the major protein for the low-density lipoprotein and helps in its transport. (practo.com)
Assessing the levels of Apolipoprotein B directly reflects the low-density lipoprotein levels. (practo.com)
Associations of nonfasting lipid measurements (total cholesterol, HDL-C, non-HDL-C, direct and calculated low-density lipoprotein cholesterol [LDL-C], and apolipoproteins [Apo] A1 and B) with CVD were compared using Cox models adjusting for classical risk factors, and predictive utility was determined by the C-index and net reclassification index. (gla.ac.uk)
The role of human apolipoprotein A-II (apoA-II) in the remodeling of human high density lipoproteins (HDL) was investigated during incubation of native and reduced-carboxamidomethylated (RCM) HDL3 with a lipoprotein-depleted plasma fraction (LPDP) in the presence of triglyceride-rich particles (TGRP) isolated from Intralipid. (unimi.it)
Kinetic studies suggest that a two-step process is involved in the formation of small, preβ-HDL3, by which changes in lipid composition cause alterations in lipoprotein structure/stability, favoring the dissociation of apolipoproteins and reduction of particle size. (unimi.it)
Apolipoprotein A-I (apoAI) is the major structural component of high density lipoprotein (HDL), exhibiting significant atheroprotective functions [ 6 ]. (biomedcentral.com)
Apolipoprotein B (apoB) is the major protein constituent of the atherogenic low density lipoprotein (LDL), intermediate density lipoprotein (IDL), very low density lipoprotein (VLDL) and of chylomicrons [ 6 ]. (biomedcentral.com)
Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)
Change in LDL-C, total cholesterol, non-high-density lipoprotein cholesterol (-HDL-C), proprotein convertase subtilisin-kexin type 9 (PCSK9), and apolipoprotein B were assessed. (thecardiologyadvisor.com)
Trends in apolipoprotein B, non-high-density lipoprotein, and low-density lipoprotein for adults 60 years and older by use of lipid-lowering medications: United States, 2005-2006 to 2013-2014 [Research Letter]. (cdc.gov)
The Endocrine Society does not recommend routinely measuring lipoprotein particle heterogeneity in patients with hypertriglyceridemia, suggesting that although apolipoprotein B or lipoprotein(a) levels may be useful, results of other apolipoproteins are generally not clinically useful. (medscape.com)

Although apolipoprotein E polymorphism ε4 allele (ApoE4) and slow gait are well-known risk factors for cognitive impairment, examination of their combined effect on cognitive function is lacking. (frontiersin.org)
To examine the relation between apolipoprotein E status and risk of Alzheimer disease (AD) in a defined population and estimate the fraction of incident AD attributable to the ε allele. (elsevier.com)
The apolipoprotein E ε4 allele is an important genetic risk factor for AD but accounts for a fairly small fraction of disease occurrence in this population-based study. (elsevier.com)
The strongest genetic risk factor is the presence of the epsilon4 allele of the apolipoprotein E gene, which encodes a protein that has a crucial role in cholesterol metabolism. (lidsen.com)

The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
The plasma levels of Lp-PLA2 provide positively a key link with apoB, apoB/apoA-1 among stable CAD, denoting the communication between Lp-PLA2 and apolipoprotein particles in the state of CAD. (hindawi.com)
In particular, LDL cholesterol , the "bad" cholesterol , relies on transport by apolipoprotein B (apoB). (nebula.org)
Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
Low apoB levels may indicate Bassen-Kornzweig syndrome ( abetalipoproteinemia ), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)
Levels of the apolipoprotein B (ApoB) also increased for the EPA/DHA group by 14 milligrams per decilitre (mg/dL) and 12 mg/dL compared to oleic acid and ALA-rich diet, respectively. (dairyreporter.com)
ApoB is the main apolipoprotein of LDL cholesterol and is responsible for the transport of cholesterol to tissues. (dairyreporter.com)
Moreover, we were able to identify changes in apolipoproteins, specifically apoB, which are also associated with increased CVD risk. (healthandwellnessclub.com)

Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)
These particles consist of a core of cholesterol esters and triglycerides surrounded by a monolayer of free cholesterol, phospholipids, and proteins (apolipoproteins). (medscape.com)
Apolipoprotein A is a protein carried in HDL ("good") cholesterol. (ahealthyme.com)
Conclusions: Measurement of total cholesterol and HDL-C in the nonfasted state is sufficient to capture the lipid-associated risk in CVD prediction, with no meaningful improvement from addition of apolipoproteins, direct or calculated LDL-C. (gla.ac.uk)
As a result of this connection, elevated levels of apolipoprotein B are linked to elevated LDL cholesterol and an increased risk of coronary heart disease. (nebula.org)
Many of the same dietary recommendations are made for lowering apolipoprotein B as for lowering LDL cholesterol. (nebula.org)
Methods and Results: YYR supplementation markedly reduced total cholesterol, LDL, and apolipoprotein B100 levels in plasma compared with the placebo. (elsevierpure.com)
To check younger people's cholesterol levels , measurements were recorded periodically from 1999 to 2016 for general cholesterol, HDL, LDL, non-HDL cholesterol, triglycerides (a kind of fats), and apolipoprotein B (a protein element of LDL). (healthlable.com)

Regulation and clearance of apolipoprotein B-containing lipoproteins. (medlineplus.gov)
Other apolipoproteins (A, C, D, E, and their subtypes) are soluble and are exchanged between lipoproteins during metabolism. (medscape.com)
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. (genetex.com)
Apolipoproteins combine with lipid to form lipoproteins and help in the transport of lipids throughout the bloodstream. (practo.com)
Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins / L. Calabresi, A. Lucchini, G. Vecchio, C. Sirtori, G. Franceschini. (unimi.it)
However, there are no available studies investigating the possible influence of mesenteric fat to specific apolipoproteins, constituents of serum lipoproteins and key molecules to their function. (biomedcentral.com)

Mouse Apolipoprotein M (APOM) ELISA kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
CusabioHuman Apolipoprotein M (APOM) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible. (joplink.net)
Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. (ku.dk)
Apolipoprotein M (ApoM) is a type of apolipoprotein. (lu.se)
We also showed that proteins that bind to S1P, such as the HDL-bound apolipoprotein M (ApoM), direct specific biological functions of S1P by activating S1P receptors in unique ways. (harvard.edu)

Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. (hindawi.com)
BACKGROUND AND AIMS: Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). (bris.ac.uk)

Further analysis identified increased apolipoprotein B levels as the main contributor to an increased risk of coronary heart disease. (nebula.org)

We found several differences in plasma proteins of bGH mice compared to controls, including increased apolipoprotein E (five isoforms), haptoglobin (four isoforms) and mannose-binding protein-C (one out of three isoforms), and decreased transthyretin (six isoforms). (nih.gov)

APPROACH AND RESULTS: Triglyceride transport and the metabolism of apos (apolipoproteins) B48, B100, C-III, and E after a fat-rich meal were investigated before and on evolocumab treatment in 13 subjects with type 2 diabetes. (helsinki.fi)
Apolipoprotein A-II (apoAII) is the second most important protein component of HDL and seems to have a significant role in triglyceride metabolism [ 7 ]. (biomedcentral.com)
There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM . (bvsalud.org)

CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. (ox.ac.uk)
OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. (ox.ac.uk)

2017. A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. . (umich.edu)
Studies have identified a gene on chromosome 22 encoding for apolipoprotein L1 (APOL1) which has been associated with a variety of nephropathies. (cdc.gov)

In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
Lately, it was established that ApoA5 is present in the human serum and it can be detected by polyclonal antibodies against both the HN2 and COOH termini, but at much lower concentration than other apolipoproteins. (prospecbio.com)
Apolipoprotein F (APO-F) is a novel low abundance liver fibrosis biomarker and its concentration decreases in human serum and plasma across liver fibrosis stages. (ox.ac.uk)
Aim of the present study was to investigate the correlation of mesenteric fat thickness (MFT) with serum apolipoprotein levels in patients undergoing digital subtraction angiography in a single center. (biomedcentral.com)

In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. (pharmaapis.com)

In apolipoprotein E‑knockout mice, a high‑fat diet reduced miR‑126 expression and induced apoptosis as determined by the upregulation of caspase‑3 activity. (spandidos-publications.com)
Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia. (duke.edu)
Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice. (cdc.gov)

CusabioMouse Apolipoprotein A-I-binding protein (APOA1BP) ELISA kit is Available at Gentaur Genprice with the fastest. (joplink.net)
The results concerning Lp-PLA2 levels were calculated by Elisa Kit, while apolipoprotein particles were measured by the department of laboratory. (hindawi.com)

Apolipoprotein E binds avidly to beta amyloid (A beta) peptide, a major component of senile plaque of Alzheimer's disease, in an isoform-specific manner. (jci.org)

Apolipoprotein A levels can be measured. (ahealthyme.com)
The accuracy of your heart disease risk is better when both apolipoprotein A and apolipoprotein B levels are measured and looked at together. (ahealthyme.com)
Smoking cigarettes, taking diuretics, or taking medicines that contain androgens can also cause lower levels of apolipoprotein A. (ahealthyme.com)
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. (broadinstitute.org)
Levels of apolipoprotein A-I (apoA-I) have been found to be reduced in the lungs of patients with IPF, while administration of human apoA-I has been shown to reduce bleomycin-induced collagen deposition in a murine model. (centerwatch.com)
Therefore high levels of Apolipoprotein B in the blood may increase the risk of cardiovascular diseases (heart diseases). (practo.com)
This test is performed to determine whether you have normal or abnormal levels of Apolipoprotein B in the blood. (practo.com)
This study examined genetic data of over 440,000 individuals of European descent to identify genomic regions associated with apolipoprotein B levels in the blood. (nebula.org)
The researchers identified 250 genetic variants, including 203 novel variants, associated with apolipoprotein B levels. (nebula.org)
However, the risk does increase when the levels of apolipoprotein B are increased as well. (nebula.org)

Apolipoprotein (apo) E4 is a risk factor for heart disease, Alzheimer's disease, and other forms of neurodegeneration, but the underlying mechanisms are unknown. (nih.gov)
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. (jci.org)
Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease. (bvsalud.org)

Identification of 255 genetic variants associated with the apolipoprotein B level in the blood and analysis of its contribution to the risk of coronary heart disease. (nebula.org)

Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer. (bvsalud.org)

This is a specimen procurement, clinical phenotyping and genotyping protocol that will assess whether holo-apoA-I and apolipoprotein A-I mimetic peptides, can attenuate key pathogenic manifestations of IPF, such as proliferation and extracellular matrix generation by pulmonary fibroblasts, which may serve as evidence to support future human clinical trials of apoA-I for the treatment of IPF. (centerwatch.com)

ICC/IF analysis of U2OS cells using GTX64377 Apolipoprotein B antibody. (genetex.com)
There are currently no references for Apolipoprotein B antibody (GTX64377) . (genetex.com)

In this way, apolipoprotein A can help to lower your risk for cardiovascular disease. (ahealthyme.com)

Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)

Furthermore, because each LDL particle contains one molecule of apolipoprotein B-100, the majority of apolipoprotein B (apo-B) would indirectly test the number of LDL particles. (hindawi.com)

Human apolipoprotein C1 (APOC1) is a 57 amino acid long polypeptide that, through its potent inhibition of cholesteryl ester transferase protein, helps regulate the transfer of lipids between lipid particles. (escholarship.org)

Nous avons réalisé un essai en double aveugle contre placebo sur 50 patients atteints de diabète de type 2 randomisés pour recevoir 2 g/jour d'acides gras oméga 3 purifiés ou un placebo pendant 10 semaines. (who.int)

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (medlineplus.gov)
But some studies suggest that apolipoprotein A test results are a good measure of your heart disease risk. (ahealthyme.com)
Consequently, understanding the relation between Lp-PLA2 and apolipoprotein may suggest several potential determinants with regard to the risk of CAD. (hindawi.com)
Major lipids, apolipoproteins, and risk of vascular disease. (ox.ac.uk)

Interactions between apolipoprotein E (apo E) and amyloid beta (A β ) are associated with the peripheral clearance of A β and are important to the development of neurodegenerative diseases. (scirp.org)
Apolipoprotein E influences amyloid-beta clearance from the murine per" by E. Hone, Ian J. Martins et al. (edu.au)

Synthetic peptide conjugated to KLH derived from within residues 200 to the C-terminus of Human Apolipoprotein A I. (abcam.com)
Recombinant Human Apolipoprotein A I ( ab50239 ) can be used as a positive control in WB. (abcam.com)
Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis. (nih.gov)
The structure of human apolipoprotein C-1 in four different crystal forms. (escholarship.org)
Group (LLC+MEF (Molecular arrhythmic effects of intracycline after dendritic children gain much before, its correlation and that the inclusion are milestos is not in TNBC intentiated with on these and WC has not apolipoprotein (MRC) curvey in human criteria (r = 0.52-18 weeks (figure 6A), increase and COL1A1 mutation. (cymaticsconference.com)

Apolipoprotein A-1 (apoA-1) comprises nearly 70% of the apolipoproteins on the HDL particles, allowing an effective calculation of HDL concentration. (hindawi.com)
HDL particles are composed of apolipoprotein A1 (apoA1) and enzymes embedded in a spherical phospholipid layer that surrounds a lipid core. (northwestern.edu)

The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)

Anatomy1

Diseases2

Chemicals and Drugs31

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor. (1/107)

Mass spectral study of polymorphism of the apolipoproteins of very low density lipoprotein. (2/107)

Protective effect of apolipoprotein A I, A II, C I and C II on endothelial cells injury induced by low density lipoprotein. (3/107)

Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide. (4/107)

Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease. (5/107)

Structural studies of a baboon (Papio sp.) plasma protein inhibitor of cholesteryl ester transferase. (6/107)

Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. (7/107)

Long terminal repeats are used as alternative promoters for the endothelin B receptor and apolipoprotein C-I genes in humans. (8/107)

Apolipoprotein C-I

Apolipoproteins C

Apolipoprotein C-III

Lipoproteins, VLDL

Triglycerides

Apolipoprotein A-I

NK Cell Lectin-Like Receptor Subfamily A

Receptors, NK Cell Lectin-Like

Apolipoproteins E

Apolipoprotein B-100

Antigens, Ly

Apolipoproteins B

Apolipoprotein E4

Apolipoprotein E3

Apolipoprotein A-II

Apolipoproteins

Apolipoprotein C-II

Apolipoproteins A

Apolipoprotein B-48

Apolipoprotein E2

Lipoproteins, HDL

Apoprotein(a)

Cholesterol

Lipoproteins

Lipoprotein(a)

Apolipoproteins D

Lipoproteins, LDL

Lipids

Receptors, LDL

Atherosclerosis

Cholesterol, HDL

Arteriosclerosis

Liver

Phosphatidylcholine-Sterol O-Acyltransferase

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor. (1/107)

Mass spectral study of polymorphism of the apolipoproteins of very low density lipoprotein. (2/107)

Protective effect of apolipoprotein A I, A II, C I and C II on endothelial cells injury induced by low density lipoprotein. (3/107)

Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide. (4/107)

Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease. (5/107)

Structural studies of a baboon (Papio sp.) plasma protein inhibitor of cholesteryl ester transferase. (6/107)

Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. (7/107)

Long terminal repeats are used as alternative promoters for the endothelin B receptor and apolipoprotein C-I genes in humans. (8/107)

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