Apolipoprotein A-I
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Apolipoproteins E
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Apolipoprotein B-100
Apolipoproteins B
Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.
Apolipoprotein E4
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Apolipoprotein E3
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.
Apolipoprotein C-III
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).
Apolipoprotein A-II
The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.
Apolipoproteins
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
Apolipoprotein C-II
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.
Apolipoproteins A
Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
Apolipoprotein B-48
A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.
Apolipoprotein E2
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Apolipoprotein C-I
A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.
Apolipoproteins C
A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.
Lipoproteins, HDL
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Apoprotein(a)
A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.
Cholesterol
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Lipoproteins, VLDL
A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.
Lipoprotein(a)
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Apolipoproteins D
A glycoprotein component of HIGH-DENSITY LIPOPROTEINS that transports small hydrophobic ligands including CHOLESTEROL and STEROLS. It occurs in the macromolecular complex with LECITHIN CHOLESTEROL ACYLTRANSFERASE. Apo D is expressed in and secreted from a variety of tissues such as liver, placenta, brain tissue and others.
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Receptors, LDL
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Atherosclerosis
Cholesterol, HDL
Arteriosclerosis
Liver
Phosphatidylcholine-Sterol O-Acyltransferase
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Cholesterol, LDL
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
ATP Binding Cassette Transporter 1
Hyperlipoproteinemia Type III
An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
Hyperlipoproteinemias
Lipid Metabolism
Hypolipoproteinemias
Chylomicrons
Genotype
Receptors, Lipoprotein
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Alleles
Hypobetalipoproteinemias
Conditions with abnormally low levels of BETA-LIPOPROTEINS (low density lipoproteins or LDL) in the blood. It is defined as LDL values equal to or less than the 5th percentile for the population. They include the autosomal dominant form involving mutation of the APOLIPOPROTEINS B gene, and the autosomal recessive form involving mutation of the microsomal triglyceride transfer protein. All are characterized by low LDL and dietary fat malabsorption.
Cholesterol Esters
Lipoproteins, IDL
A mixture of very-low-density lipoproteins (VLDL), particularly the triglyceride-poor VLDL, with slow diffuse electrophoretic mobilities in the beta and alpha2 regions which are similar to that of beta-lipoproteins (LDL) or alpha-lipoproteins (HDL). They can be intermediate (remnant) lipoproteins in the de-lipidation process, or remnants of mutant CHYLOMICRONS and VERY-LOW-DENSITY LIPOPROTEINS which cannot be metabolized completely as seen in FAMILIAL DYSBETALIPOPROTEINEMIA.
Lipoprotein Lipase
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
Hyperlipoproteinemia Type II
Clusterin
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Hypercholesterolemia
Cholesterol, VLDL
Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Kringles
Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Tangier Disease
An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.
Hyperlipidemia, Familial Combined
Base Sequence
Dietary Fats
Mice, Transgenic
Heterozygote
ATP-Binding Cassette Transporters
High-Density Lipoproteins, Pre-beta
A highly dense subclass of the high-density lipoproteins, with particle sizes below 7 nm. They are also known as nascent HDL, composed of a few APOLIPOPROTEIN A-I molecules which are complexed with PHOSPHOLIPIDS. The lipid-poor pre-beta-HDL particles serve as progenitors of HDL3 and then HDL2 after absorption of free cholesterol from cell membranes, cholesterol esterification, and acquisition of apolipoproteins A-II, Cs, and E. Pre-beta-HDL initiate the reverse cholesterol transport process from cells to liver.
Dimyristoylphosphatidylcholine
Electrophoresis, Polyacrylamide Gel
Amino Acid Sequence
Cholesterol Ester Transfer Proteins
Cytidine Deaminase
Hyperlipoproteinemia Type IV
A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Abetalipoproteinemia
An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.
Lipoproteins, HDL3
Phenotype
RNA Editing
A process that changes the nucleotide sequence of mRNA from that of the DNA template encoding it. Some major classes of RNA editing are as follows: 1, the conversion of cytosine to uracil in mRNA; 2, the addition of variable number of guanines at pre-determined sites; and 3, the addition and deletion of uracils, templated by guide-RNAs (RNA, GUIDE).
Isoelectric Focusing
Gene Frequency
Low Density Lipoprotein Receptor-Related Protein-1
Cells, Cultured
Ultracentrifugation
Disease Models, Animal
Nephelometry and Turbidimetry
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
Lipase
LDL-Receptor Related Proteins
Carrier Proteins
Phosphatidylcholines
Protein Binding
Oleic Acid
Serum Amyloid A Protein
Gene Expression Regulation
Peptide Fragments
Aryldialkylphosphatase
An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).
Glycoproteins
Risk Factors
Reference Values
Amyloid beta-Peptides
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Scavenger Receptors, Class B
Biological Transport
Hypolipidemic Agents
Hyperlipoproteinemia Type V
A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .
Intestines
Mutation
Genetic Predisposition to Disease
Electrophoresis, Agar Gel
Hypobetalipoproteinemia, Familial, Apolipoprotein B
Circular Dichroism
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Sterol O-Acyltransferase
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Protein Structure, Secondary
Gene Expression
Coronary Disease
Pedigree
Protein Isoforms
Lipolysis
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Rabbits
Brachiocephalic Trunk
Lipocalins
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Phospholipid Transfer Proteins
Chromatography, Gel
Dyslipidemias
Receptors, Scavenger
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Polymorphism, Restriction Fragment Length
Transfection
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Lecithin Acyltransferase Deficiency
An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.
Blotting, Western
Macrophages, Peritoneal
Immunoblotting
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Chylomicron Remnants
Metabolic products of chylomicron particles in which TRIGLYCERIDES have been selectively removed by the LIPOPROTEIN LIPASE. These remnants carry dietary lipids in the blood and are cholesterol-rich. Their interactions with MACROPHAGES; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS in the artery wall can lead to ATHEROSCLEROSIS.
Probucol
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Hyperlipoproteinemia Type I
Hepatocytes
Tumor Cells, Cultured
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Fatty Acids
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Binding, Competitive
Lipoproteins, HDL2
Immunohistochemistry
Aging
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Haptoglobins
Immunoassay
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Amyloid
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Esterification
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
DNA Primers
Binding Sites
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Hepatocyte Nuclear Factor 4
Iodine Radioisotopes
Transcription, Genetic
Promoter Regions, Genetic
Disease Progression
Cerebral Amyloid Angiopathy
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Carotid Arteries
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Vascular Cell Adhesion Molecule-1
Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)
Aorta, Thoracic
Electrophoresis, Gel, Two-Dimensional
Liposomes
Chromatography, Affinity
Lipid Peroxidation
Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia. (1/471)
There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV. This region in turn has been proposed to modulate the expression of hyperlipidemia in the commonest genetic form of dyslipidemia, familial combined hyperlipidemia (FCHL). The hypothesis tested here was whether vitamin A (retinol), by controlling the expression of the AI-CIII-AIV gene cluster, plays a role in modulating the hyperlipidemic phenotype in FCHL. We approached the subject by studying three genetic variants of this region: a C1100-T transition in exon 3 of the apoC-III gene, a G3206-T transversion in exon 4 of the apoC-III gene, and a G-75-A substitution in the promoter region of the apoA-I gene. The association between plasma vitamin A concentrations and differences in the plasma concentrations of apolipoproteins A-I and C-III based on the different genotypes was assessed in 48 FCHL patients and 74 of their normolipidemic relatives. The results indicated that the subjects carrying genetic variants associated with increased concentrations of apoA-I and C-III (C1100-T and G-75-A) also presented increased plasma concentrations of vitamin A. This was only observed among the FCHL patients, which suggested that certain characteristics of these patients contributed to this association. The G3206-T was not associated with changes in either apolipoprotein concentrations or in vitamin A. In summary, we report a relationship between genetically determined elevations of proteins of the AI-CIII-AIV gene cluster and vitamin A in FCHL patients. More studies will be needed to confirm that vitamin A plays a role in FCHL which might also be important for its potential application to therapeutical approaches. (+info)Apolipoprotein A-I charge and conformation regulate the clearance of reconstituted high density lipoprotein in vivo. (2/471)
While low apolipoprotein A-I (apoA-I) levels are primarily associated with increased high density lipoprotein (HDL) fractional catabolic rate (FCR), the factors that regulate the clearance of HDL from the plasma are unclear. In this study, the effect of lipid composition of reconstituted HDL particles (LpA-I) on their rate of clearance from rabbit plasma has been investigated. Sonicated LpA-I containing 1 to 2 molecules of purified human apoA-I and 5 to 120 molecules of palmitoyl-oleoyl phosphatidylcholine (POPC) exhibit similar charge and plasma FCR to that for lipid free apoA-I, 2.8 pools/day. Inclusion of 1 molecule of apoA-II to an LpA-I complex increases the FCR to 3.5 pools/day, a value similar to that observed for exchanged-labeled HDL3. In contrast, addition of 40 molecules of triglyceride, diglyceride, or cholesteryl ester to a sonicated LpA-I containing 120 moles of POPC and 2 molecules of apoA-I increases the negative charge of the particle and reduces the FCR to 1.8 pools/day. Discoidal LpA-I are the most positively charged lipoprotein particles and also have the fastest clearance rates, 4.5 pools/day. Immunochemical characterization of the different LpA-I particles shows that the exposure of an epitope at residues 98 to 121 of the apoA-I molecule is associated with an increased negative particle charge and a slower clearance from the plasma. We conclude that the charge and conformation of apoA-I are sensitive to the lipid composition of LpA-I and play a central role in regulating the clearance of these lipoproteins from plasma. conformation regulate the clearance of reconstituted high density lipoprotein in vivo. (+info)Dietary restriction of saturated fat and cholesterol decreases HDL ApoA-I secretion. (3/471)
We examined the mechanisms responsible for the decrease in HDL cholesterol (HDL-C) levels after the consumption of a diet low in total fat, saturated fat, and cholesterol. Twenty-one subjects with a mean age of 58+/-12 years were placed on a baseline isocaloric diet (15% protein, 49% carbohydrate, 36% fat, and 150 mg/1000 kcals of cholesterol) and then switched to an NCEP Step 2 diet (15% protein, 60% carbohydrate, 25% fat, and 45 mg/1000 kcals of cholesterol). After 6 or 24 weeks on each diet, subjects received a 15-hour primed-constant infusion of [5,5,5-2H3]-L-leucine. HDL apoA-I and apoA-II tracer curves were determined by gas chromatography-mass spectrometry and fitted to a monoexponential equation. Compared with the baseline diet, consumption of the Step 2 diet lowered HDL-C mean levels by 15% (1.03+/-0.23 to 0.88+/-0.16 mmol/L, P<0.001), apoA-I by 12% (1.25+/-0.15 to 1.10+/-0.13 g/L, P<0. 001) and the TC/HDL-C ratio by 5% (0.145+/-0.04 to 0.137+/-0.03). No significant changes were observed in apoA-II levels and HDL particle size with diet. HDL apoA-I fractional catabolic rate did not change (0.219+/-0.052 to 0.220+/-0.043 pools/day, P=0.91) but HDL apoA-I secretion rate decreased by 8% (12.26+/-3.07 to 10.84+/-2.11 mg. kg-1. day-1, P=0.03) during consumption of the Step 2 diet. There was no effect of diet on apoA-II fractional catabolic rate or secretion rate. Our results indicate that the decrease in HDL-C and apoA-I levels during the isocaloric consumption of a Step 2 diet paralleled the reductions in apoA-I secretion rate. (+info)Acute effects of intravenous infusion of ApoA1/phosphatidylcholine discs on plasma lipoproteins in humans. (4/471)
To investigate the metabolism of nascent HDLs, apoA1/phosphatidylcholine (apoA1/PC) discs were infused IV over 4 hours into 7 healthy men. Plasma total apoA1 and phospholipid (PL) concentrations increased during the infusions. The rise in plasma apoA1 was greatest in small prebeta-migrating particles not present in the infusate. Total HDL unesterified cholesterol (UC) also increased simultaneously. After stopping the infusion, the concentrations of apoA1, PL, HDL UC, and small prebeta HDLs decreased, whereas those of HDL cholesteryl ester (CE) and large alpha-migrating apoA1 containing HDLs increased. ApoB-containing lipoproteins became enriched in CEs. Addition of apoA1/PC discs to whole blood at 37 degrees C in vitro also generated small prebeta HDLs, but did not augment the transfer of UC from erythrocytes to plasma. We conclude that the disc infusions increased the intravascular production of small prebeta HDLs in vivo, and that this was associated with an increase in the efflux and esterification of UC derived from fixed tissues. The extent to which the increase in tissue cholesterol efflux was dependent on that in prebeta HDL production could not be determined. Infusion of discs also reduced the plasma apoB and apoA2 concentrations, and increased plasma triglycerides and apoC3. Thus, nascent HDL secretion may have a significant impact on prebeta HDL production, reverse cholesterol transport and lipoprotein metabolism in humans. (+info)Apolipoprotein B-containing lipoproteins in renal failure: the relation to mode of dialysis. (5/471)
BACKGROUND: The aim of this study was to establish whether there is a differential effect of mode of dialysis, hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) on the dyslipidemia of renal failure. METHODS: The lipoprotein profile was determined in 61 non-diabetic patients on chronic HD (N = 30) and CAPD treatment (N = 31), and in a control group of 27 healthy subjects. The analysis included the measurement of individual apolipoprotein (apo) A- and apo B-containing lipoproteins (LPs) separated by sequential immunoaffinity chromatography. Apo A-containing lipoproteins include lipoprotein A-I with apo A-I and lipoprotein A-I:A-II with apo A-I and apo A-II as the main protein constituents, whereas apo B-containing lipoproteins comprise simple cholesterol-rich lipoprotein B (LP-B), with apo B as the only protein moiety and complex triglyceride (TG)-rich lipoprotein B complex (LP-Bc) particles with apo B, apo A-II, apo C, and/or apo E as the protein constituents. RESULTS: CAPD patients had significantly higher concentrations of total cholesterol (6.8 vs. 5.1 mmol/liter), low-density lipoprotein (LDL) cholesterol (4.6 vs. 3.2 mmol/liter), TG (2.3 vs. 1.5 mmol/liter), apo B (155.3 vs. 105.7 mg/dl), LP-B (136.0 vs. 91.9 mg/dl), and LP-Bc (19.3 vs. 13.8 mg/dl) than HD patients. Both HD and CAPD patients had significantly higher TG, VLDL cholesterol, apo C-III, and apo E and significantly lower high-density lipoprotein cholesterol, apo A-II, and lipoprotein A-I:A-II levels than control subjects. The distribution of apo C-III in high-density lipoprotein and VLDL-LDL was altered in CAPD patients in comparison with control subjects. This suggests that the removal of TG-rich lipoproteins is less efficient in patients on CAPD. Normotriglyceridemic (NTG; TG < or = 1.7 mmol/liter, 150 mg/dl) CAPD patients had significantly higher levels of TC, LDL cholesterol, apo B, and LP-B than NTG-HD patients. There was little difference in the LP-Bc levels between NTG-CAPD, NTG-HD, and controls. Similarly, hypertriglyceridemic (HTG) CAPD patients had significantly higher TC, LDL cholesterol, apo B, and LP-B levels than HTG-HD patients. The LP-Bc levels were significantly increased in HTG-HD and HTG-CAPD patients compared with controls, but the slightly higher levels in the CAPD patients did not differ significantly from the HD group. CONCLUSION: CAPD and HD patients have a lipoprotein profile characteristic of renal failure. Patients on long-term CAPD have higher levels of cholesterol-rich apo B-containing lipoproteins unrelated to TG levels. Many patients on CAPD also have a substantial elevation of the plasma concentrations of TG-rich LPs. The clinical significance of increased levels of potentially atherogenic LP-B during CAPD remains to be investigated. (+info)Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis. (6/471)
Two lines of transgenic mice, hAIItg-delta and hAIItg-lambda, expressing human apolipoprotein (apo)A-II at 2 and 4 times the normal concentration, respectively, displayed on standard chow postprandial chylomicronemia, large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) but greatly reduced high density lipoprotein (HDL). Hypertriglyceridemia may result from increased VLDL production, decreased VLDL catabolism, or both. Post-Triton VLDL production was comparable in transgenic and control mice. Postheparin lipoprotein lipase (LPL) and hepatic lipase activities decreased at most by 30% in transgenic mice, whereas adipose tissue and muscle LPL activities were unaffected, indicating normal LPL synthesis. However, VLDL-triglyceride hydrolysis by exogenous LPL was considerably slower in transgenic compared with control mice, with the apparent Vmax of the reaction decreasing proportionately to human apoA-II expression. Human apoA-II was present in appreciable amounts in the VLDL of transgenic mice, which also carried apoC-II. The addition of purified apoA-II in postheparin plasma from control mice induced a dose-dependent decrease in LPL and hepatic lipase activities. In conclusion, overexpression of human apoA-II in transgenic mice induced the proatherogenic lipoprotein profile of low plasma HDL and postprandial hypertriglyceridemia because of decreased VLDL catabolism by LPL. (+info)Protective effect of apolipoprotein A I, A II, C I and C II on endothelial cells injury induced by low density lipoprotein. (7/471)
OBJECTIVE: To investigate the protective effect of apo-lipoprotein (apo) A I, A II, C I and C II, the main proteins in high density lipoprotein (HDL), on the morphology and function of human umbilical vein endothelial cells injured with low density lipoprotein (LDL) in vitro. METHODS: Cultured human endothelial cells derived from umbilical veins were exposed to LDL, HDL, and apoA I, A II, C I and C II. The morphology of endothelial cells was examined with phase contrast and transmission electron microscope. The released amount of lactate dehydrogenase (LDH) and 6-keto-prostaglandin F1 alpha (PGF1 alpha) was also measured. RESULTS: Endothelial cells after being injured by LDL showed cell contraction, increased release of LDH and decreased secrection of prostacyclin (PGI2). However, the addition of HDL, and apoA I, A II, C I and C II before incubation with LDL inhibited the cellular injury induced by LDL as demonstrated by lowered LDH release, increased level of PGF1 alpha and prevention of morphological changes. CONCLUSION: The results indicate that apoA I, A II, C I and C II, as well as HDL, may play an important role in combating atherogenesis by protecting endothelial cells from damages induced by LDL. (+info)ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice. (8/471)
High density lipoprotein (HDL) cholesterol levels are inversely related to the risk of developing coronary heart disease. Apolipoprotein (apo) A-II is the second most abundant HDL apolipoprotein and apoA-II knockout mice show a 70% reduction in HDL cholesterol levels. There is also evidence, using human apoA-II transgenic mice, that apoA-II can prevent hepatic lipase-mediated HDL triglyceride hydrolysis and reduction in HDL size. These observations suggest the hypothesis that apoA-II maintains HDL levels, at least in part, by inhibiting hepatic lipase. To evaluate this, apoA-II knockout mice were crossbred with hepatic lipase knockout mice. Compared to apoA-II-deficient mice, in double knockout mice there were increased HDL cholesterol levels (57% in males and 60% in females), increased HDL size, and decreased HDL cholesteryl ester fractional catabolic rate. In vitro incubation studies of plasma from apoA-II knockout mice, which contains largely apoA-I HDL particles, showed active lipolysis of HDL triglyceride, whereas similar studies of plasma from apoA-I knockout mice, which contains largely apoA-II particles, did not. In summary, these results strongly suggest that apoA-II is a physiological inhibitor of hepatic lipase and that this is at least part of the mechanism whereby apoA-II maintains HDL cholesterol levels. (+info)
Apolipoprotein A-II/ApoA2 Antibodies: Novus Biologicals
A05] Sheep Anti-Human Apolipoprotein AII Polyclonal Antibody - AcademyBiomed
B05] Biotinylated Sheep Anti-Human Apolipoprotein AII - AcademyBiomed
Apolipoprotein A-II
- Apolipoprotein A2
Summary Report | CureHunter
APOA2 - Wikipedia
Human Apolipoprotein A-II Enrichment Displaces Paraoxonase From HDL and Impairs Its Antioxidant Properties | Circulation...
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Distribution of subclasses of HDL containing apoA-I without apoA-II (LpA-I) in normolipidemic men and women. | Arteriosclerosis...
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Lysozyme (LYZ) Gene, Full Gene Analysis - Mayo Medical Laboratories | Genetics and Pharmacogenomics Catalog
Gentaur Molecular :Alpha Dia \ Anti Mouse Apolipoprotein A I protein IgG, aff pure \ APOA13-A
Plus it
anti-Apolipoprotein A2 antibody (HRP) | GeneTex
260 Rem (or .260AI) w. SAAMI (or standard length) .060 FB? | Long Range Hunting Forum
2830 ([PATCH] Fix vulnerabilities in BLX driver)
- GDAL
Abstract 102: Profound Exclusion of Apolipoprotein A-II from Selective Hepatic Cholesteryl Ester Uptake | Arteriosclerosis,...
Formation of apolipoprotein-specific high-density lipoprotein particles from lipid-free apolipoproteins A-I and A-II |...
Hypatia - The association of serum lipids, lipoproteins and apolipoproteins with selected trace elements and...
TNO Repository search for: subject:apoprotein
Apolipoproteins A
Summary Report | CureHunter
Production and purification of recombinant mouse apolipoprotein F :: University of Southern California Dissertations and Theses
EIF4A2 - Wikipedia
9892A-II Eyeglasses Design 20X Watch Repair Magnifier with LED Light (Black)
Mass spectrometric determination of apolipoprotein molecular stoichiometry in reconstituted high density lipoprotein particles<...
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View Anwendungen Der Erddrucktheorie Bei Der Berechnung Von Spundwänden Und Kaimauern 1940
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Sea Otters
Staten Island Mental Health Society Inc | ZoomInfo.com
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Apolipoprotein C-II
... (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The ... 1989). "A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II". J. ... 1988). "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II ... 1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. ...
Apolipoprotein A-II
... is a protein that in humans is encoded by the APOA2 gene. APOA2 encodes apolipoprotein A-II, (ApoA-II) ... Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein ... Lackner KJ, Law SW, Brewer HB (Sep 1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS ... Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. ApoA-II has been shown to interact ...
Apolipoprotein E
... even if they have two ApoE4 alleles, thus reducing the risk from nine or ten times the odds of getting AD down to just two ... The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). The ... "Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of ... Yet those with two ε4 alleles have up to 20 times the risk of developing AD. There is also evidence that the APOE2 allele may ...
Apolipoprotein B
... (ApoB) is a protein that in humans is encoded by the APOB gene. Apolipoprotein B is the primary apolipoprotein ... Su Q, Tsai J, Xu E, Qiu W, Bereczki E, Santha M, Adeli K (2009). "Apolipoprotein B100 acts as a molecular link between lipid- ... MedlinePlus Encyclopedia: Apolipoprotein B100 Cromwell WC, Otvos JD, Keyes MJ, Pencina MJ, Sullivan L, Vasan RS, Wilson PW, ... Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver ...
Apolipoprotein D
"Plasma apolipoprotein concentrations in familial apolipoprotein A-I and A-II deficiency (Tangier disease)". Metabolism: ... Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I". The Journal of Biological ... Apolipoprotein D (ApoD) is a component of HDL that has no marked similarity to other apolipoprotein sequences. It has a high ... "Entrez Gene: APOD apolipoprotein D". Muffat J, Walker DW (January 2010). "Apolipoprotein D: an overview of its role in aging ...
Anti-apolipoprotein antibodies
These two activities can be differentiated by the binding to Apo-H domains, whereas binding to the 5th domain promotes that ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ... In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a ... 70 (2): 342-5. doi:10.1055/s-0038-1649577. PMID 8236146. Schousboe I, Rasmussen MS (1995). "Synchronized inhibition of the ...
Apolipoprotein C-III
Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK (Jul 1985). "Distribution of apolipoprotein A-I, C-II, C-III, and E ... Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. ... Karathanasis SK (Oct 1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV ... "Two initiator-like elements are required for the combined activation of the human apolipoprotein C-III promoter by upstream ...
Apolipoprotein
... C (ApoC-I, apo ApoC-II, apo ApoC-III, and ApoC-IV) Apolipoprotein D Apolipoprotein E Apolipoprotein F ... Apolipoprotein H - a misnomer Apolipoprotein L Apolipoprotein M Apolipoprotein(a) Exchangeable apolipoproteins (apoA, apoC, and ... apolipoprotein C-II for lipoprotein lipase and apolipoprotein A-I (apoA1) for lecithin-cholesterol acyltransferase).[citation ... "Human apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells". ...
Apolipoprotein L1
... is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different ... G2 is an in-frame deletion of the two amino acid residues, N388 and Y389.[citation needed] Apolipoprotein L1 (apoL1) is a minor ... Recently, two coding sequence variants in APOL1 have been shown to associate with kidney disease in a recessive fashion while ... APOL1 is a member of a family of apolipoproteins which also includes six other proteins and it is a member of bcl2 genes which ...
Lipocalin
Retinyl esters (present in meats) and beta-carotene (present in plants) are the two main sources of retinoids in the diet. ... apolipoprotein D; beta-lactoglobulin; complement component C8 gamma chain; crustacyanin; epididymal-retinoic acid binding ... In the event that two species names have identical designations, they are discriminated from one another by adding one or more ... share only one or two of these. Proteins known to belong to this family include alpha-1-microglobulin (protein HC); major ...
Low-density lipoprotein receptor-related protein 8
Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (Jun 1996). "Human apolipoprotein E ... Upon reelin binding, Dab1 is phosphorylated by two tyrosine kinases, Fyn and Src. The phosphorylated Dab1 then causes further ... Apolipoprotein E (ApoE) plays an important role in phospholipid and cholesterol homeostasis. After binding ApoER2, ApoE is ... Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the ...
Gladys Maestre
1996). Apolipoprotein E and Alzheimer's Disease. Research and Perspectives in Alzheimer's Disease. Berlin, Heidelberg: Springer ... "Maestre CV" (PDF). Maestre, Gladys Elena (1996). Apolipoproteins and Alzheimer's disease (Thesis). OCLC 36257436. Staff, M. D. ... "The apolipoprotein ?4 allele in patients with Alzheimer's disease". Annals of Neurology. 34 (5): 752-754. doi:10.1002/ana. ... "Apolipoprotein E and alzheimer's disease: Ethnic variation in genotypic risks". Annals of Neurology. 37 (2): 254-259. doi: ...
APOL2
Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene ... Two transcript variants encoding the same protein have been found for this gene. >sp,Q9BQE5,1-337 ... "Entrez Gene: APOL2 apolipoprotein L, 2". "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2". Liao W, Goh FY, Betts RJ, ... "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2". Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant ...
APOL6
Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene. This gene is a member of the apolipoprotein L gene ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ... "Entrez Gene: APOL6 apolipoprotein L, 6". Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser. ... Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, ...
APOM
Apolipoprotein M is a protein that in humans is encoded by the APOM gene. The protein encoded by this gene is an apolipoprotein ... Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully ... "Entrez Gene: APOM apolipoprotein M". Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes ... Overview of all the structural information available in the PDB for UniProt: O95445 (Human Apolipoprotein M) at the PDBe-KB. v ...
Causal model
However, the two models do not have the same meaning and can be falsified based on data (that is, if observational data show an ... Katan MB (March 1986). "Apolipoprotein E isoforms, serum cholesterol, and cancer". Lancet. 1 (8479): 507-8. doi:10.1016/s0140- ... Where two models match on all relevant variables and data from one model is known to be unbiased, data from one population can ... The two effects have a common cause. There exists a (non-causal) spurious correlation between A {\displaystyle A} and C {\ ...
Hepatocyte nuclear factor 4 alpha
Zannis VI, Kan HY, Kritis A, Zanni E, Kardassis D (Mar 2001). "Transcriptional regulation of the human apolipoprotein genes". ... two mechanisms for repression". Molecular and Cellular Biology. 20 (1): 187-95. doi:10.1128/MCB.20.1.187-195.2000. PMC 85074. ... Ginsburg GS, Ozer J, Karathanasis SK (Jul 1995). "Intestinal apolipoprotein AI gene transcription is regulated by multiple ... "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human ...
DAB1
... and apolipoprotein E receptor-2 (ApoER2; 602600), are also required. Both receptors bound Dab1 on their cytoplasmic tails and ... "Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E ... 19 (2): 239-49. doi:10.1016/S0896-6273(00)80936-8. PMID 9292716. S2CID 1273677. Long H, Bock HH, Lei T, Chai X, Yuan J, Herz J ... 47 (2): 165-74. doi:10.1002/gcc.20519. PMID 18008369. S2CID 24674687. Deguchi K, Inoue K, Avila WE, et al. (2003). "Reelin and ...
Mothers against decapentaplegic homolog 2
Zannis VI, Kan HY, Kritis A, Zanni E, Kardassis D (March 2001). "Transcriptional regulation of the human apolipoprotein genes ... The name is a combination of the two. During Drosophila research, it was found that a mutation in the gene MAD in the mother ... MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against ... 11 (1-2): 5-13. doi:10.1016/S1359-6101(99)00024-6. PMID 10708948. Miyazono K (2000). "TGF-beta signaling by Smad proteins". ...
David J. Galton
Thus one extra sialyl residue on apolipoprotein C3 impairs its action on lipoprotein lipase. This can affect expression of the ... Galton, DJ (August 2017). "Clarifying complex inheritance: apolipoprotein C3 and atherosclerosis". Current Opinion in ... "An abnormal triglyceride-rich lipoprotein containing excess sialylated apolipoprotein". Journal of Clinical Investigation. 69 ( ... "Hypertriglyceridaemia associated with an abnormal triglyceride-rich lipoprotein carrying excess apolipoprotein". Lancet. 2 ( ...
Heme oxygenase
Ferrous ion is a common nomenclature used in the HMOX field for Iron(II) which appears in PubChem. The iron liberated from HMOX ... peptides such as adrenomedullin and apolipoprotein; and iii) hemin. NRF2 inducers with downstream HO-1 induction include: ... Endogenous inducers include i) lipids such as lipoxin and epoxyeicosatrienoic acid; and ii) ... HO-2 is encoded by the HMOX2 gene. HO-2 is 36 kDa and shares 47% similarity with the HO-1 amino acid sequence; notably HO-2 has ...
Apolipoprotein C-I
"Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene". The Journal of Biological ... Servillo L, Brewer HB, Osborne JC (February 1981). "Evaluation of the mixed interaction between apolipoproteins A-II and C-I ... Curry MD, McConathy WJ, Fesmire JD, Alaupovic P (April 1981). "Quantitative determination of apolipoproteins C-I and C-II in ... Rozek A, Buchko GW, Cushley RJ (June 1995). "Conformation of two peptides corresponding to human apolipoprotein C-I residues 7- ...
Farnesoid X receptor
Seol W, Choi HS, Moore DD (Jan 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel ... "Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression". Gastroenterology. 125 (2): 544-55. doi:10.1016/ ... Seol W, Choi HS, Moore DD (Jan 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel ... 290 (1-2): 35-43. doi:10.1016/S0378-1119(02)00557-7. PMID 12062799. Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, ...
APOBEC1
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC (2002). "Two proteins essential for apolipoprotein B mRNA ... Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in ... Like all APOBEC proteins, A1 coordinates a zinc atom with two cysteine and one histidine residues that serve as a Lewis acid. ... Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec ...
Reelin
Two transcription initiation sites and two polyadenylation sites are identified in the gene structure. The reelin protein ... All members of this family are receptors for Apolipoprotein E (ApoE). Therefore, they are often synonymously referred to as ' ... Moreover, the two main receptors of reelin are able to form clusters that most probably play a major role in the signaling, ... The two main reelin receptors seem to have slightly different roles: VLDLR conducts the stop signal, while ApoER2 is essential ...
Apolipoprotein C-IV
2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical ... Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene. APOC4 is a ... in the apolipoprotein E, C-I, and C-II gene locus". Genomics. 28 (2): 291-300. doi:10.1006/geno.1995.1144. PMID 8530039. Human ... "Entrez Gene: apolipoprotein C-IV". Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization ...
Lipoprotein lipase
Kim SY, Park SM, Lee ST (January 2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. ... Two molecules of ApoC-II can attach to each LPL dimer.> It is estimated that up to forty LPL dimers may act simultaneously on a ... In the Golgi apparatus, the oligosaccharides are further altered to result in either two complex chains, or two complex and one ... "Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II". Proc. Natl. Acad. Sci ...
A1CF
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC (April 2002). "Two proteins essential for apolipoprotein B mRNA ... Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme ... Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec ... Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 ...
Hyperlipidemia
Online Mendelian Inheritance in Man (OMIM): Apolipoprotein C-II Deficency - 207750 Yamamura T, Sudo H, Ishikawa K, Yamamoto A ( ... "Familial type I hyperlipoproteinemia caused by apolipoprotein C-II deficiency". Atherosclerosis. 34 (1): 53-65. doi:10.1016/ ... Hyperlipoproteinemia type II is further classified into types IIa and IIb, depending mainly on whether elevation in the ... The lipoprotein density and type of apolipoproteins it contains determines the fate of the particle and its influence on ...
Microsomal triglyceride transfer protein
Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. Click on genes, ... Gordon DA (1997). "Recent advances in elucidating the role of the microsomal triaglyceride transfer protein in apolipoprotein B ... 1999). "A common binding site on the microsomal triaglyceride transfer protein for apolipoprotein B and protein disulfide ... The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b ...
Cerebral amyloid angiopathy
apolipoprotein E (APOE) ε2 and ε4 are associated with increased risk of getting cerebral amyloid antipathy. The use of ... Thal, Dietmar Rudolph; Ghebremidhin, Estifanos; Rüb, Udo; Haruyasu, Yamaguchi; Del Tredici, Kelly; Braak, Heiko (2002). "Two ... In type 2 CAA pathology, amyloid deposits are present in leptomeningeal and cortical arteries and arterioles, but not in ... 49 (2): 491-497. doi:10.1161/STROKEAHA.117.016990. PMC 5892842. PMID 29335334. Verbeek, M. M.; Waal, R. M. de; Vinters, Harry V ...
LDL receptor
The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. In humans, the LDL ... Recent evidence has connected MI risk with coding-sequence mutations at two genes functionally related to APOA5, namely ... It is a cell-surface receptor that recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer ... novel insights from recent kinetic studies of apolipoprotein B-100 metabolism". Atherosclerosis. Supplements. 2 (3): 1-4. doi: ...
Dementia with Lewy bodies
Probable DLB can be diagnosed when dementia and at least two core features are present, or when one core feature and at least ... Berge G, Sando SB, Rongve A, Aarsland D, White LR (November 2014). "Apolipoprotein E ε2 genotype delays onset of dementia with ... Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias. It is a common form of dementia, but the ... Two 1997 discoveries highlighted the importance of Lewy body inclusions in neurodegenerative processes: a mutation in the SNCA ...
WNK3
These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family ... 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. ... 74 (2): 134-44. doi:10.1111/j.1399-0004.2008.01028.x. PMID 18498374. S2CID 22008997. Wilson FH, Disse-Nicodème S, Choate KA, et ... 318 (2): 263-72. PMID 7757816. Kahle KT, Ring AM, Lifton RP (2008). "Molecular physiology of the WNK kinases". Annu. Rev. ...
Index of biochemistry articles
... angiotensin II - angiotensin receptor - ankyrin - annexin II - antibiotic - antibody - apoenzyme - apolipoprotein - apoptosis ... interferon type II - interferon-alpha - interferon-beta - interleukin receptor - interleukin-1 receptor - interleukin-2 ... Articles related to biochemistry include: Contents: Top 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 2-amino-5- ... photosystem II - phototransduction - phylogenetics - phylogeny - physical chemistry - physiology - phytohaemagglutinin - ...
Coconut oil
... of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins ... 2 (6 ed.). John Wiley & Sons, Inc. p. 465. doi:10.1002/047167849X. ISBN 978-0-471-38552-3. "Rice bran oil". RITO Partnership. ... Proper harvesting of the coconut (the age of a coconut can be 2 to 20 months when picked) makes a significant difference in the ... 16 (2): 87-94. doi:10.1080/09546630510035832. PMID 16019622. S2CID 18445488. "Smoke points of oils" (PDF). "Olive oil, salad or ...
ACAT2
Yao XM, Wang CH, Song BL, Yang XY, Wang ZZ, Qi W, Lin ZX, Chang CC, Chang TY, Li BL (Dec 2005). "Two human ACAT2 mRNA variants ... polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects". Biochimica et ... Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S (Feb 2008). "Expression of two isozymes of acyl-coenzyme A: cholesterol ... Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D ( ...
Dendritic cell
Monocytes can be induced to differentiate into dendritic cells by a self-peptide Ep1.B derived from apolipoprotein E. These are ... This precursor, termed pre-DC, lacks MHC class II surface expression, and is distinct from monocytes, which primarily give rise ... are probably of mesenchymal rather than hematopoietic origin and do not express MHC class II, but are so named because they are ... "Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E." (PDF). J Immunol. 181 (10): 6859-71. ...
ABCA1
Luciani MF, Denizot F, Savary S, Mattei MG, Chimini G (May 1994). "Cloning of two novel ABC transporters mapping on human ... ABCA1 mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins (apoA1 and apoE) (reverse cholesterol ... Oram JF, Vaughan AM (June 2000). "ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins". ... October 1999). "The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway". The ...
Chromosome 6
... heterodimer MHC class II, DR (6p21.3) Mold / Biotoxin Susceptibility HLA-DPA1 and HLA-DPB1 forms HLA-DP, MHC class II, DP ( ... encoding protein Apolipoprotein M (6p21.33) ATXN1: encoding protein Ataxin 1 (6p16.3-p16.76) TSBP1: encoding protein TSBP1 ( ... People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material ... 6p21.3) HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3) HLA-DRA, HLA-DRB1, HLA-DRB3, HLA ...
Estrogen receptor beta
Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB- ... and apolipoprotein A1 (ApoA-1). Polymorphism may affect ERβ function and lead to altered responses in postmenopausal women ... January 2020). "Optimized immunohistochemical detection of estrogen receptor beta using two validated monoclonal antibodies ... is one of two main types of estrogen receptor-a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ ...
APOBEC3G
The two ways of inhibition are distinct from each other, but they can replace each other in vivo. It was first identified by ... APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the APOBEC3G gene that ... Only the latter two mechanisms have been extensively supported. The amount that is incorporated into virions is dependent on ... However, unlike the typical cytidine deaminases, APOBEC3G contains a unique alpha helix between two beta sheets in the ...
Miriam E. Nelson
"Shape Up Somerville two-year results: A community-based environmental change intervention sustains weight reduction in children ... and Apolipoproteins". Journal of Clinical Endocrinology & Metabolism. 68 (1): 17-21. doi:10.1210/jcem-68-1-17. PMID 2491859. ... November 2, 2015. Retrieved 2020-12-21. "The Social Network Diet: Why You Really Are The Company You Keep". HuffPost. February ... 18 (2): 201-18. doi:10.1123/japa.18.2.201. PMC 4308058. PMID 20440031.[non-primary source needed] Gustin, Georgina (April 18, ...
Antiphospholipid syndrome
These tests must be carried out on a minimum of two occasions at least 6 weeks apart and be positive on each occasion, ... apolipoprotein H) complex. The use of testing for antibodies specific for individual targets of aPL such as β2 glycoprotein 1 ... This is tested for by using a minimum of two coagulation tests that are phospholipid-sensitive, due to the heterogeneous nature ... The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two positive blood test ...
ATG9B
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5 ... Ban HJ, Heo JY, Oh KS, Park KJ (2010). "Identification of type 2 diabetes-associated combination of SNPs using support vector ...
Primidone
What is known is that ten years later, Monroe went on to publish the results of a meta-analysis of two controlled clinical ... and apolipoproteins A and B. It was first reported to exacerbate hepatic porphyria in 1975. In 1981, it was shown that ... In the three adults who are reported to have succumbed, the doses were 20-30 g. However, two adult survivors ingested 30 g 25 g ... Primidone is a congener of phenobarbital where the carbonyl oxygen of the urea moiety is replaced by two hydrogen atoms. The ...
Dyslipidemia
Low density lipoproteins are made up of cholesterol, TG, phospholipids, and apolipoproteins. LDL-C molecules bind to the ... Physicians and basic researchers classify dyslipidemias in two distinct ways. One way is its presentation in the body ( ... 80 (2): 179-181. doi:10.1111/bcp.12612. PMC 4541964. PMID 25702706. \ (CS1 maint: url-status, Articles with short description, ... doi:10.1016/S0140-6736(05)67667-2. PMID 16310551. S2CID 40744740. Sabatine, Marc S. (March 2019). "PCSK9 inhibitors: clinical ...
Wolfgang Patsch
Strobl W, Gorder N, Lin-Lee YC, Gotto AM Jr, Patsch W. Role of thyroid hormones in apolipoprotein A-I gene expression in rat ... apolipoproteins A-I and B, and HDL density subfractions: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 2001 ... Thyroid hormone influences the maturation of apolipoprotein A-I messenger RNA in rat liver. J Biol Chem. 1995;270:3996-4004. ... Other genetic factors with relevance for obesity, type 2 diabetes and the metabolic syndrome also were studied in collaboration ...
LRP10
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ... 2001). "A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta- ...
HPR (gene)
2007). "Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum". Proc. Natl. Acad ... 119 (2): 291-4. doi:10.1016/S0166-6851(01)00420-0. PMID 11814582. Vanhollebeke B, Nielsen MJ, Watanabe Y, et al. ( ...
Fenofibrate
... and apolipoprotein B (apo B), and to increase high-density lipoprotein cholesterol (HDL) in adults with primary ... whereas their effect on HDL metabolism is associated with changes in HDL apolipoprotein expression." Fenofibrate is a fibrate ... 2 (4): 370-380. doi:10.1001/jamacardio.2016.4828. PMC 5470410. PMID 28030716. Kim NH, Han KH, Choi J, Lee J, Kim SG (September ... 129 (25 Suppl 2): S1-45. doi:10.1161/01.cir.0000437738.63853.7a. PMID 24222016. "AbbVie Inc. et al; Withdrawal of Approval of ...
Joseph Brain (academic)
Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: ... 2007; 33(2):53-70. Brain JD, Curran MA, Donaghey T, Molina R. Responses of the lungs to nanomaterials depend on exposure, ... Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. Am J Respir Cell Mol Biol ...
USF1
This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have ... "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E ... Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D ( ... 365 (Pt 2): 481-8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176. Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, ...
Integrin subunit beta like 1
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5 ... 37 (2): 1663-9. doi:10.1007/s13277-015-3919-8. PMID 26307393. S2CID 54485581. v t e This article incorporates text from the ...
Gapmer
Kynamro targets the mRNA product of the APOB gene, which codes for the Apolipoprotein B-100 protein, a component of low-density ... LNAs, 2'-OMe, or 2'-F modified bases are chemical analogs of natural RNA nucleic acids. These modifications allow for an ... The mimics are typically composed of locked nucleic acids (LNA), 2'-OMe, or 2'-F modified bases. LNA sequences are RNA ... 34 (2): 310-320. doi:10.1007/s11095-016-2063-5. ISSN 1573-904X. PMID 27896589. S2CID 7147120. Mipomersen [package insert]. ...
List of skin conditions
The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the " ... Familial defective apolipoprotein B-100 Familial dysbetalipoproteinemia (broad beta disease, remnant removal disease) Familial ... The dermis contains two vascular networks that run parallel to the skin surface-one superficial and one deep plexus-which are ... In normal skin, the rate of production equals the rate of loss; about two weeks are needed for a cell to migrate from the basal ...
Epigenetics of neurodegenerative diseases
Class I and II HDAC inhibitors such as trichostatin A, vorinostat, and sodium butyrate, and Class III HDACis, such as ... and familial inheritance of apolipoprotein E allele epsilon 4. In addition to these common factors, there are a number of other ... There exists two variations of myasthenia gravis with respect to age and gender demographics: early-onset myasthenia gravis, ... Sodium butyrate Sodium butyrate is a class I and II HDACi and has been shown to recover learning and memory after 4 weeks, ...
Donepezil
In a secondary analysis, a subgroup of individuals with the apolipoprotein E4 genotype showed sustained benefits with donepezil ... January 2015). "Donepezil improves gait performance in older adults with mild Alzheimer's disease: a phase II clinical trial". ... 2 (8000): 1403. doi:10.1016/s0140-6736(76)91936-x. PMID 63862. S2CID 43250282. Kása P, Rakonczay Z, Gulya K (August 1997). "The ... 124 (2): 195-206. doi:10.1016/j.pharmthera.2009.07.001. PMC 2785038. PMID 19619582. McCarthy AD, Owens IJ, Bansal AT, McTighe ...
WHO EMRO | Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes...
Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patients ... The aim of this study was to determine the effects of purified omega-3 fatty acids on serum lipoproteins, apolipoprotein B-100 ... Apo B-100), apolipoprotein A-I (Apo A-I), malondialdehyde (MDA) (as index for lipid peroxidation), and glycaemic control in ... apolipoproteins and malondialdehyde in type 2 diabetes patients Section menu. You are here. *Eastern Mediterranean Health ...
Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese...
T1 - Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in ... Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese ... Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese ... title = "Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in ...
Effects of Evolocumab on the Postprandial Kinetics of Apo (Apolipoprotein) B100-and B48-Containing Lipoproteins in Subjects...
apolipoprotein cardiovascular diseases chylomicrons evolocumab kinetics TRIGLYCERIDE-RICH LIPOPROTEINS PCSK9 INHIBITOR ... APPROACH AND RESULTS: Triglyceride transport and the metabolism of apos (apolipoproteins) B48, B100, C-III, and E after a fat- ... Effects of Evolocumab on the Postprandial Kinetics of Apo (Apolipoprotein) B100-and B48-Containing Lipoproteins in Subjects ... Effects of Evolocumab on the Postprandial Kinetics of Apo (Apolipoprotein) B100-and B48-Containing Lipoproteins in Subjects ...
Relationship between Plasma Lipoprotein-Associated Phospholipase A2 Concentrations and Apolipoprotein in Stable Coronary Artery...
Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been ... while apolipoprotein particles were measured by the department of laboratory. ,i,Results,/i,. The plasma concentration of Lp- ... levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. ... denoting the communication between Lp-PLA2 and apolipoprotein particles in the state of CAD. ...
NHANES 2011-2012: Apolipoprotein B Data Documentation, Codebook, and Frequencies
LBXAPB - Apolipoprotein (B) (mg/dL). Variable Name: LBXAPB. SAS Label: Apolipoprotein (B) (mg/dL). English Text: Apolipoprotein ... LBDAPBSI - Apolipoprotein (B) (g/L). Variable Name: LBDAPBSI. SAS Label: Apolipoprotein (B) (g/L). English Text: Apolipoprotein ... Apolipoprotein B (ApoB_G) Data File: ApoB_G.xpt First Published: January 2014. Last Revised: NA ... Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. ...
Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins
The role of human apolipoprotein A-II (apoA-II) in the remodeling of human high density lipoproteins (HDL) was investigated ... The role of human apolipoprotein A-II (apoA-II) in the remodeling of human high density lipoproteins (HDL) was investigated ... Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins. L. Calabresi. Primo. ;A. Lucchini;G. ... Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins / L. Calabresi, A. Lucchini, G. Vecchio ...
APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B [Homo sapiens (human)] - Gene - NCBI
Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]. Expression. ... apolipoprotein B mRNA editing enzyme catalytic subunit 3Bprovided by HGNC. Primary source. HGNC:HGNC:17352 See related. Ensembl ... APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B [ Homo sapiens (human) ] Gene ID: 9582, updated on 4-Dec- ... Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis. ...
LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis
Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are ... Saura, J., Petegnief, V., Wu, X., Liang, Y. and Paul, S.M. (2003) Microglial Apolipoprotein E and Astroglial Apolipoprotein J ... Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral clearance of Aβ and are ... LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis () ...
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis | Clinical Research Trial Listing ( Pulmonary...
Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis ... Levels of apolipoprotein A-I (apoA-I) have been found to be reduced in the lungs of patients with IPF, while administration of ... clinical phenotyping and genotyping protocol that will assess whether holo-apoA-I and apolipoprotein A-I mimetic peptides, can ... Not sure for Males and females over the age of 18 with a diagnosis of IPF inclusion criteria 2 ...
The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease
491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased ... The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimers disease Neurosci ... The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with ...
Anti-Apolipoprotein A I antibody (ab64308) | Abcam
Rabbit polyclonal Apolipoprotein A I antibody. Validated in WB, ICC/IF, sELISA and tested in Human. Cited in 8 publication(s). ... Anti-Apolipoprotein A I antibody. See all Apolipoprotein A I primary antibodies. ... to Apolipoprotein A I (ab20918) at 1ug/ml and Detector Antibody Rabbit polyclonal to Apolipoprotein A I (ab64308) at 0.5ug/ml ... Recombinant Human Apolipoprotein A I (ab50239) can be used as a positive control in WB. This antibody gave a positive signal in ...
Apolipoprotein A-II - MRM Proteomics
Apolipoprotein B100: MedlinePlus Medical Encyclopedia
Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Regulation and clearance of apolipoprotein B-containing lipoproteins. In: Ballantyne CM, ed. Clinical Lipidology: A Companion ...
IMSEAR at SEARO: Apolipoprotein E Polymorphism In Two Populations Of Andhra Pradesh.
Venkatramana P, Reddy Chengal, Ferrell R E. Apolipoprotein E Polymorphism In Two Populations Of Andhra Pradesh. Indian Journal ... No significant difference was observed between these two populations for apolipoprotein (apo) E polymorphism. The genotypic ... Apolipoprotein (apo) E genotypes were determined on 182 subjects of Kshatriya and 38 subjects of the Mala populations of Andhra ... Five genotypes (2/3, 2/4, 3/3, 3/4, 4/4) in the Kshatriya and three genotypes (2/3, 3/3, 3/4) in the Mala, representing three ...
Low LDL Cholesterol (Hypobetalipoproteinemia): Practice Essentials, Pathophysiology, Beta apolipoproteins
Evidence for two separate gene defects: one associated with an abnormal apoB species, apolipoprotein B-37; and a second ... Beta apolipoproteins. Beta apolipoproteins are the largest of the apolipoproteins. They are critically important for the ... Apolipoprotein B-100 deficiency. Intestinal steatosis despite apolipoprotein B-48 synthesis. J Clin Invest. 1985 Aug. 76(2):403 ... CMs, VLDL, and LDL carry apolipoproteins on their surface; these apolipoproteins have lipid-soluble segments, the beta ...
Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways<...
Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ... Apolipoprotein M (ApoM) is a type of apolipoprotein. It is well known that high-density lipoprotein (HDL) decreases ...
Confirmation of the ϵ4 allele of the apolipoprotein E gene as a risk factor for late‐onset Alzheimer's disease | Neurology
Confirmation of the ϵ4 allele of the apolipoprotein E gene as a risk factor for late‐onset Alzheimers disease. T. Brousseau, S ... We compared apolipoprotein E polymorphism distribution between patients with sporadic late-onset AD (n = 36) and controls of ... In this study, we investigated the possible association of a genetic polymorphism of the apolipoprotein E gene with late-onset ... Confirmation of the ϵ4 allele of the apolipoprotein E gene as a risk factor for late‐onset Alzheimers disease ...
Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience | BMC Medicine | Full Text
Tissue and/or cellular expressions of interleukin-1 alpha (IL-1α), apolipoprotein E (ApoE), amyloid β (Aβ) precursor protein ( ... 2; P = 0.01). 3) Aβ plaques were noted at early ages in our epilepsy patients, regardless of APOE genotype (APOE ε4,4 age 10; ... Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience. Access & Citations. * 5421 Article ...
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study<...
... and conducted a two-sample Mendelian randomization analysis. We compared our genetic findings to observational associations of ... Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study. Atherosclerosis. 2020 ... Apolipoprotein A-I concentrations and risk of coronary artery disease : A Mendelian randomization study. In: Atherosclerosis. ... Apolipoprotein A-I concentrations and risk of coronary artery disease : A Mendelian randomization study. / Karjalainen, Minna K ...
3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase - BRENDA Enzyme Database
PAF-acetylhydrolase II, Type II platelet-activating factor-acetylhydrolase, PAF-AH (II), plasma lipoprotein-associated ... platelet-activating factor acetylhydrolase II, PAF-AH II, platelet-activating factor-acetylhydrolase, lipoprotein-associated ... PAF acetylhydrolase II, platelet-activating-factor acetylhydrolase, platelet activating factor-acetylhydrolase, platelet- ... 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine. + H2O. = 1-alkyl-sn-glycero-3-phosphocholine. + acetate. ...
IJERPH | Free Full-Text | Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters
Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and ... apolipoprotein E; T2DM, type 2 diabetes mellitus; MetSy, metabolic syndrome; LVH, left ventricular hypertrophy; IVSth, ... Two countries that may particularly benefit from foods that mediate the risks for and assist with management of T2DM are China ... used in two studies were found to be effective at lowering serum leptin levels and restoring them to physiological levels [40, ...
Baseline platelet count independently predicts long-term adv... : Cardiology Plus
ApoAI: Apolipoprotein AI; ApoB: Apolipoprotein B; BUN: Blood urea nitrogen; Cr: Creatinine; GLU: Glucose; HDL-C: High-density ... angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonist (ARB), clopidogrel, aspirin, and statins (Tables ... 2]. Bairey Merz CN, Alberts MJ, Balady GJ, et al. ACCF/AHA/ACP 2009 competence and training statement: a curriculum on ... Figure 2.: Cumulative Kaplan-Meier estimates of the time to the first adjudicated occurrence of primary endpoint and secondary ...
Gene: [08p21/CLU] clusterin (complement lysis inhibitor, SP-40,40, apolipoprotein J); sulfated glycoprotein 2 (testosterone...
Expression of human apolipoprotein A-II apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia<...
Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced ... Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced ... Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced ... Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced ...
Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B...
beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the...
Screening of serum by using a surface plasmon resonance analysis assay identified beta2-glycoprotein-I/apolipoprotein H as a ... apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin ... apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin ... beta 2-Glycoprotein I, Biosensing Techniques, Blood Proteins, Calcium, Cardiolipins, Cultured Tumor Cells, Endocytosis, ...
APOA5 Protein Human Recombinant | Apolipoprotein A5 | ProSpec
Reconstituted APOA5 Human can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C ... Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3, APOAV. ... but at much lower concentration than other apolipoproteins. ...
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Apolipoprotein B) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-05817. USA, UK & Europe Distribution. ... Rat ApoB (Apolipoprotein B) ELISA Kit , G-EC-05817. Rating * Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 stars ... Rat ApoB (Apolipoprotein B) ELISA Kit , G-EC-05817 , Gentaur Elisa Kits ... Storage: An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the ...
APOELipoproteinsProteinGenotypeApoBProteinsAlzheimer'sGeneMetabolismApoMAllelesCholesterolAtherosclerosisPolymorphismAbstractProportional to the concentrationParticle sizeVLDLBiomarkersLipidInhibitionELISAPatientsCardiovascularAPOL12019MimeticReceptorsDementiaPeptideReceptorSerumConcentrationRiskMRNAPhospholipids1998HaptoglobinAtheroscleroticLevelsDEFICIENCYGeneticHumanTriglyceridesInflammatoryPuncturesTypeParticlesRatio
APOE10
- The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. (nih.gov)
- The genotypic distribution of apoE was at Hardy-Weinberg equilibrium in these two populations. (who.int)
- Objective: Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein epsilon-4 (APOE-epsilon4) allele. (cdc.gov)
- We conclude that apoE-deficient mice over-expressing human apoA-II constitute useful animal models with which to study the mechanisms leading to overproduction of VLDL, and that apoA-II may function to regulate VLDL production. (uab.cat)
- Late-onset and sporadic Alzheimer's disease are associated with the apolipoprotein E (apoE) type 4 allele expressing the protein isoform apoE4. (jci.org)
- Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories. (ox.ac.uk)
- Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the ε4 allele (highest genetic risk factor for Alzheimer's disease) on memory. (ox.ac.uk)
- COG1410, a mimetic peptide derived from the apolipoprotein E (apoE) receptor binding region, exerts positive effect on neurological deficits in early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH). (duke.edu)
- One of the biggest risk factors for Alzheimer's disease is the apolipoprotein E (APOE) e4 gene. (medicalnewstoday.com)
- According to the Alzheimer's Association, adults who possess one copy of the APOE e4 gene are three times more likely to develop the disease than those without the gene, while those with two copies are 8-12 times more likely to develop Alzheimer's. (medicalnewstoday.com)
Lipoproteins8
- OBJECTIVE: Increased risk of atherosclerotic cardiovascular disease in subjects with type 2 diabetes is linked to elevated levels of triglyceride-rich lipoproteins and their remnants. (helsinki.fi)
- The role of human apolipoprotein A-II (apoA-II) in the remodeling of human high density lipoproteins (HDL) was investigated during incubation of native and reduced-carboxamidomethylated (RCM) HDL3 with a lipoprotein-depleted plasma fraction (LPDP) in the presence of triglyceride-rich particles (TGRP) isolated from Intralipid. (unimi.it)
- Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins / L. Calabresi, A. Lucchini, G. Vecchio, C. Sirtori, G. Franceschini. (unimi.it)
- Regulation and clearance of apolipoprotein B-containing lipoproteins. (medlineplus.gov)
- Other apolipoproteins (A, C, D, E, and their subtypes) are soluble and are exchanged between lipoproteins during metabolism. (medscape.com)
- Expression of apolipoprotein A-II (apoA-II), a high density lipoprotein (HDL) of unknown function, in transgenic mice produced increased concentration of apoB-containing lipoproteins and decreased HDL. (uab.cat)
- The primary objective of this study was to determine the variability in cholesterol carrying capacity of low density lipoproteins (LDLs) and other apolipoprotein B (apo B)-containing lipoproteins in normolipidemic men. (utmb.edu)
- Grundy, Scott M. / Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100 . (utmb.edu)
Protein19
- Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
- The small products are protein-rich and cholesterol-poor, and consist of two different particles: a component with pre-β mobility, containing only apoA-I, and a component with α mobility, containing both apoA-I and apoA-II. (unimi.it)
- Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)
- In this study, we explored the activation of autophagy during EBI by measuring the Beclin-1 and LC3B-II protein levels. (duke.edu)
- Novel biomarkers of risk, such as apolipoprotein (Apo) A1 and ApoB (2), and the inflammatory markers C-reactive protein (CRP), fibrinogen, and homocysteine (3-5), have been proposed. (cdc.gov)
- Docking, protein - protein interaction, and immunoprecipitation studies with antiautophagy-related gene (ATG)14L, anti- UV radiation resistance-associated gene (UVRAG), or Rubicon antibodies suggested the formation of ATG14L complex I and UVRAG complex II in G0- podocytes and the formation of Rubicon complex III in G1- and G2- podocytes . (bvsalud.org)
- To examine plasma protein differences in bGH mice relative to controls, samples at 2, 4, 8, 12 and 16 months of age were analyzed by two-dimensional gel electrophoresis followed by identification using mass spectrometry. (nih.gov)
- We found several differences in plasma proteins of bGH mice compared to controls, including increased apolipoprotein E (five isoforms), haptoglobin (four isoforms) and mannose-binding protein-C (one out of three isoforms), and decreased transthyretin (six isoforms). (nih.gov)
- Cardiometabolic risk factors as apolipoprotein B, triglyceride/HDL-cholesterol ratio and C-reactive protein, in adolescents with and without obesity: cross-sectional study in middle class suburban children. (bvsalud.org)
- CusabioMouse Apolipoprotein A-I-binding protein (APOA1BP) ELISA kit is Available at Gentaur Genprice with the fastest. (joplink.net)
- If serotransferrin & APOH is typed in, since the two terms are in the PROTEIN category, the resulting list includes all protein entries matching either serotransferrin OR APOH . (expasy.org)
- If serotransferrin & human is typed in, since the two terms are in the PROTEIN category and TAXONOMY category respectively, the resulting list includes all protein entries matching both serotransferrin AND human . (expasy.org)
- The objective of this study was to determine whether the increased AKT or MAPK kinase-1/2 (MEK1/2) activity observed in endometriotic stromal cells (OSIS) from ovarian endometriomas influences levels of PR protein. (webpediatrica.com)
- Inhibiting AKT with MK-2206 or MEK1/2 with U0126 for 24 hours in the absence of R5020 increased total and nuclear PRA and PRB protein levels in OSIS but not in eutopic endometrial stromal cells from disease-free patients from disease-free patients. (webpediatrica.com)
- Inhibition of AKT or MEK1/2 increased total and nuclear PR protein in OSIS. (webpediatrica.com)
- There were no statistically significant differences in sst 5 and D 2 R mRNA expression or in sst 2 , sst 5 , and D 2 R protein expression between both groups of corticotroph adenomas. (webpediatrica.com)
- After achieving normocortisolism induced by medical therapy, cortisol-mediated sst 2 downregulation on corticotroph adenomas appears to be a reversible process at the mRNA but not at the protein level. (webpediatrica.com)
- Whether sustained normocortisolism induced by medical therapy induces re-expression of functional sst 2 protein in corticotroph adenomas and whether this increases the ACTH-lowering potency of octreotide remains to be established. (webpediatrica.com)
- The strongest genetic risk factor is the presence of the epsilon4 allele of the apolipoprotein E gene, which encodes a protein that has a crucial role in cholesterol metabolism. (lidsen.com)
Genotype3
- The dissociable effects of the gene on short- and long-term memory suggest that the effect of genotype on these two types of memories, and their neural underpinnings, might not be co-extensive. (ox.ac.uk)
- This research shows that exercise can mitigate the risk of dementia for people without the variant of the apolipoprotein genotype," he adds. (medicalnewstoday.com)
- In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. (pharmaapis.com)
ApoB3
- The plasma levels of Lp-PLA2 provide positively a key link with apoB, apoB/apoA-1 among stable CAD, denoting the communication between Lp-PLA2 and apolipoprotein particles in the state of CAD. (hindawi.com)
- The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
- FHBL is caused by an autosomal, codominant mutation in the gene for apoB ( APOB ), which is carried on chromosome 2. (medscape.com)
Proteins4
- These particles consist of a core of cholesterol esters and triglycerides surrounded by a monolayer of free cholesterol, phospholipids, and proteins (apolipoproteins). (medscape.com)
- Over the last two decades, mass spectrometry (MS)-based proteomics has been widely used to identify differentially expressed proteins between young and aged populations [ 9 , 10 ]. (aging-us.com)
- Earlier studies that employed two-dimensional electrophoresis (2-DE) usually identified several hundreds of proteins that only covered a small portion of the proteome, and their quantification was largely based on label-free methods [ 11 ]. (aging-us.com)
- We also showed that proteins that bind to S1P, such as the HDL-bound apolipoprotein M (ApoM), direct specific biological functions of S1P by activating S1P receptors in unique ways. (harvard.edu)
Alzheimer's5
- Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. (jci.org)
- Apolipoprotein E binds avidly to beta amyloid (A beta) peptide, a major component of senile plaque of Alzheimer's disease, in an isoform-specific manner. (jci.org)
- To compare the general clinical conditions and oral alterations, and also evaluate the prosthesis, in subjects diagnosed with Alzheimer's disease (AD) or Parkinson's disease (PD), attended at two geriatric centers in the city of Fortaleza - Ceará. (bvsalud.org)
- The most common cause of dementia is Alzheimer's Disease (AD) accounting for 60% to 70% of cases, followed by vascular dementia, dementia with Lewy bodies, and frontotemporal dementia 1-2 . (bvsalud.org)
- 2. The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. (pharmaapis.com)
Gene11
- Two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
- An isoform of apolipoprotein E, whose gene maps in this region, is more frequent in AD. (neurology.org)
- In this study, we investigated the possible association of a genetic polymorphism of the apolipoprotein E gene with late-onset AD. (neurology.org)
- This result indicates an association between late-onset AD and the 19q13.2 region containing the apolipoprotein E gene locus. (neurology.org)
- However, FCHL patients do not have plasma concentrations of human apoA-II as high as those of apo.E-deficient mice overexpressing human apoA-II, and the apoA-II gene has not been linked to FCHL in genome-wide scans. (uab.cat)
- Therefore, the apoA-II gene could be a 'modifier' FCHL gene influencing the phenotype of the disease in some individuals through unkown mechanisms including an action on a 'major' FCHL gene. (uab.cat)
- Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels. (childrensmercy.org)
- Gene-environment interaction of body mass index and apolipoprotein E ε4 allele on cognitive decline. (hopkinsmedicine.org)
- Gene-behavior interaction of depressive symptoms and the apolipoprotein E {varepsilon}4 allele on cognitive decline. (hopkinsmedicine.org)
- Studies have identified a gene on chromosome 22 encoding for apolipoprotein L1 (APOL1) which has been associated with a variety of nephropathies. (cdc.gov)
- 2017. A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. . (umich.edu)
Metabolism3
- APPROACH AND RESULTS: Triglyceride transport and the metabolism of apos (apolipoproteins) B48, B100, C-III, and E after a fat-rich meal were investigated before and on evolocumab treatment in 13 subjects with type 2 diabetes. (helsinki.fi)
- these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
- Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches Diabetes, Obesity and Metabolism. (nottingham.ac.uk)
ApoM3
- Apolipoprotein M (ApoM) is a type of apolipoprotein. (lu.se)
- Mouse Apolipoprotein M (APOM) ELISA kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
- CusabioHuman Apolipoprotein M (APOM) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible. (joplink.net)
Alleles1
- G0-, G1-, and G2- podocytes showed enhanced expression of light chain (LC) 3-II and beclin-1 , but a disparate expression of p62 (low in wild-type but high in risk alleles ). (bvsalud.org)
Cholesterol3
- [ 2 ] persons with a profound reduction of LDL cholesterol may have a decreased risk for heart disease. (medscape.com)
- Apolipoproteins may also offer advantages over risk because of low apolipoprotein A1 (apoA1) levels, com- lipoprotein cholesterol measurements because they are pared with 35% of men. (cdc.gov)
- The sample of 483 men and women from a cholesterol and triglyceride levels (Table 2). (cdc.gov)
Atherosclerosis1
- Atherosclerosis , 104 (1-2), 159-171. (utmb.edu)
Polymorphism4
- IMSEAR at SEARO: Apolipoprotein E Polymorphism In Two Populations Of Andhra Pradesh. (who.int)
- Venkatramana P, Reddy Chengal, Ferrell R E. Apolipoprotein E Polymorphism In Two Populations Of Andhra Pradesh. (who.int)
- No significant difference was observed between these two populations for apolipoprotein (apo) E polymorphism. (who.int)
- We compared apolipoprotein E polymorphism distribution between patients with sporadic late-onset AD (n = 36) and controls of the same age (n = 38). (neurology.org)
Abstract1
- abstract = "BACKGROUND AND AIMS: Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). (bris.ac.uk)
Proportional to the concentration1
- The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
Particle size2
- Reduction-carboxamidomethylation of HDL3 entirely converts the disulfide-linked apoA-II dimers into monomers, without affecting the structure, composition and particle size distribution of HDL3. (unimi.it)
- Kinetic studies suggest that a two-step process is involved in the formation of small, preβ-HDL3, by which changes in lipid composition cause alterations in lipoprotein structure/stability, favoring the dissociation of apolipoproteins and reduction of particle size. (unimi.it)
VLDL1
- La asociación de Apo C-II con los QUILOMICRONES del plasma, VLDL y LIPOPROTEÍNAS DE ALTA DENSIDAD es reversible y cambia rápidamente en función del metabolismo de los triglicéridos. (bvsalud.org)
Biomarkers1
- Using data from the UK Biobank, we investigated the relationship between severity of COVID-19 and metabolic syndrome-related serum biomarkers measured prior to SARS-CoV-2 infection. (jlr.org)
Lipid5
- Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (medlineplus.gov)
- Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
- This association and the ability to measure apolipoprotein in nonfasting blood samples had led to recommendations that the apo B-apo A-I ratio be used in routine clinical care, [ 3 ] despite the fact that it was not known whether this ratio is better than traditional lipid values for risk assessment and prediction and whether it adds predictive value to the Framingham risk score. (medscape.com)
- [ 4 ] They also evaluated the relationship for apoA-I. This post-hoc analysis used data from the EPIC-Norfolk study as well as the large Incremental Decrease in End Points through Aggressive Lipid Lowering (IDEAL) trial (n = 8,888), which compared the efficacy of high-dose to usual-dose statin treatment for the secondary prevention of cardiovascular events (Figure 2). (medscape.com)
- Trends in apolipoprotein B, non-high-density lipoprotein, and low-density lipoprotein for adults 60 years and older by use of lipid-lowering medications: United States, 2005-2006 to 2013-2014 [Research Letter]. (cdc.gov)
Inhibition1
- 41.9% ± 3.1%) with respect to inhibition of ACTH secretion by adenomas from group 2. (webpediatrica.com)
ELISA1
- The results concerning Lp-PLA2 levels were calculated by Elisa Kit, while apolipoprotein particles were measured by the department of laboratory. (hindawi.com)
Patients8
- In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double-blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
- Nous avons réalisé un essai en double aveugle contre placebo sur 50 patients atteints de diabète de type 2 randomisés pour recevoir 2 g/jour d'acides gras oméga 3 purifiés ou un placebo pendant 10 semaines. (who.int)
- Levels of apolipoprotein A-I (apoA-I) have been found to be reduced in the lungs of patients with IPF, while administration of human apoA-I has been shown to reduce bleomycin-induced collagen deposition in a murine model. (centerwatch.com)
- [ 1 , 2 ] Cases of elderly patients with progressive language deterioration have been described since Arnold Pick's landmark case report of 1892. (medscape.com)
- [ 112 ] These results had been called into question because of a dearth of clinical and neuroimaging data, but a 2012 prospective study of 2134 patients with severe traumatic brain injury found improved 2-week survival in patients who underwent ICP monitoring compared to those who were not monitored. (medscape.com)
- Exposure to patients with confirmed or suspected COVID-19, length of exposure, and community exposure were similar between the two groups. (doctorsnewshubb.com)
- Our objective was to compare sst and D 2 R expression levels between adenomas from patients with elevated and normalized preoperative urinary free cortisol excretion. (webpediatrica.com)
- In a preliminary study of 28 patients treated with EDAS, Gonzalez and his team found that three -- just under 11% -- had another stroke in the next two years. (brighamandwomens.org)
Cardiovascular5
- Increasing evidence states that the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. (hindawi.com)
- and 2) to evaluate prevention and treatment programs targeting cardiovascular disease in the U.S. (cdc.gov)
- Our aim was to describe the apolipoprotein was 18%, compared with 8% in Canadians of European profile with respect to cardiovascular risk in a Canadian descent (1). (cdc.gov)
- associated with cardiovascular risk (2). (cdc.gov)
- A few months after the 2007 JACC study was published, many of the same investigators - this time led by Wim A. van der Steeg, MD - published a paper looking at the role of the apo B-apolipoprotein A-I (apo B-apo A-I) ratio in cardiovascular risk assessment. (medscape.com)
APOL12
- Disrupted apolipoprotein L1-miR193a axis dedifferentiates podocytes through autophagy blockade in an APOL1 risk milieu. (bvsalud.org)
- We hypothesized that a functional apolipoprotein LI (APOL1)-miR193a axis (inverse relationship) preserves, but disruption alters, the podocyte molecular phenotype through the modulation of autophagy flux. (bvsalud.org)
20192
- Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus associated with the severe respiratory disease, coronavirus disease 2019 (COVID-19). (jlr.org)
- Am J Physiol Cell Physiol;317(2): C209-C225, 2019 08 01. (bvsalud.org)
Mimetic2
- This is a specimen procurement, clinical phenotyping and genotyping protocol that will assess whether holo-apoA-I and apolipoprotein A-I mimetic peptides, can attenuate key pathogenic manifestations of IPF, such as proliferation and extracellular matrix generation by pulmonary fibroblasts, which may serve as evidence to support future human clinical trials of apoA-I for the treatment of IPF. (centerwatch.com)
- Apolipoprotein E-Mimetic Peptide COG1410 Promotes Autophagy by Phosphorylating GSK-3β in Early Brain Injury Following Experimental Subarachnoid Hemorrhage. (duke.edu)
Receptors1
- Many descriptors for apolipoproteins , interleukin receptors, and many specific keratins were added. (bvs.br)
Dementia2
- Subsequently, the PPA syndrome was defined as a disorder limited to progressive aphasia, without general cognitive impairment or dementia, over a 2-year period. (medscape.com)
- Dementia and geriatric cognitive disorders extra 2017 9 7 (2): 240-248. (cdc.gov)
Peptide2
- Synthetic peptide conjugated to KLH derived from within residues 200 to the C-terminus of Human Apolipoprotein A I. (abcam.com)
- Negative stain electron microscopy revealed that the A beta peptide alone self-assembled into twisted ribbons containing two or three strands but occasionally into multistranded sheets. (jci.org)
Receptor4
- Screening of serum by using a surface plasmon resonance analysis assay identified beta2-glycoprotein-I/apolipoprotein H as a plasma component binding to the renal epithelial endocytic receptor megalin. (mdc-berlin.de)
- In the 1990s, we cloned the inducible cyclooxygenase (COX-2) and the first S1P receptor. (harvard.edu)
- Corticotroph pituitary adenomas often highly express the dopamine 2 receptor (D 2 R) and somatostatin receptor subtype 5 (sst 5 ). (webpediatrica.com)
- This may explain why the sst 2 -preferring somatostatin analog octreotide, compared with the multi-receptor-targeting somatostatin analog pasireotide, is generally ineffective in Cushing's disease. (webpediatrica.com)
Serum2
- In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
- Lately, it was established that ApoA5 is present in the human serum and it can be detected by polyclonal antibodies against both the HN2 and COOH termini, but at much lower concentration than other apolipoproteins. (prospecbio.com)
Concentration1
- Apolipoprotein A-1 (apoA-1) comprises nearly 70% of the apolipoproteins on the HDL particles, allowing an effective calculation of HDL concentration. (hindawi.com)
Risk2
- Consequently, understanding the relation between Lp-PLA2 and apolipoprotein may suggest several potential determinants with regard to the risk of CAD. (hindawi.com)
- Factors such as inactivity and immobility may place people with MS at increased risk of developing disabilities, and they may be disproportionately affected by chronic diseases (1,2). (cdc.gov)
MRNA1
- Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis. (nih.gov)
Phospholipids1
- Lp-PLA2 is a member of the PLA2 superfamily, characterized by the specific ability to hydrolyze the sn-2 position of phospholipids [ 6 , 7 ]. (hindawi.com)
19981
- 1998 Dec 18;258(2):65-8. (nih.gov)
Haptoglobin1
- In addition, clusterin (two out of six isoforms) and haptoglobin (four isoforms) were up-regulated in bGH mice as a function of age. (nih.gov)
Atherosclerotic1
- The localization patterns of human apolipoproteins in atherosclerotic arteries were determined using immunohistochemical examination. (elsevier.com)
Levels3
- Cerebrospinal Fluid Apolipoprotein E Levels in Delirium. (cdc.gov)
- The sst 2 expression is relatively low, likely resulting from downregulating effects of high cortisol levels. (webpediatrica.com)
- The Hemoglobin A1C Test measures an individual's average blood sugar levels over a span of 2 to 3 months. (arcpointlabs.com)
DEFICIENCY1
- Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency ( HYPERLIPOPROTEINEMIA TYPE I ) and is therefore called hyperlipoproteinemia type IB. (bvsalud.org)
Genetic1
- 5 × 10-8) in 20,370 Finnish participants, and meta-analyzed our data with a previous GWAS of apoA-I. We obtained genetic estimates of CAD from UK Biobank and CARDIoGRAMplusC4D (totaling 122,733 CAD cases) and conducted a two-sample Mendelian randomization analysis. (bris.ac.uk)
Human3
- Recombinant Human Apolipoprotein A I ( ab50239 ) can be used as a positive control in WB. (abcam.com)
- The solution structure of the 16th CCP module from human complement factor H has been determined by a combination of 2-dimensional nuclear magnetic resonance spectroscopy and restrained simulated annealing. (embl.de)
- 2. Healy G, Ristic M. Human babesiosis. (cdc.gov)
Triglycerides1
- So, LDL-P may play a useful role in patient management by helping judge the adequacy of LDL-lowering therapy, particularly among those with elevated triglycerides and reduced HDL-C. Such a role also has been proposed for apolipoprotein B (apo B). Indeed, both non-HDL-C and apo B have been proposed as secondary treatment targets after LDL-C goals have been achieved. (medscape.com)
Inflammatory1
- Our work defined how the COX-2 pathway regulated angiogenesis, cancer and inflammatory disease. (harvard.edu)
Punctures1
- As follow-up care, the patient will receive repeat lumbar punctures every 3 months for 2 years to exclude occult invasion of the central nervous system (CNS). (cdc.gov)
Type5
- The prevalence of type 2 diabetes has increased greatly in the past few years, and an even greater increase is foreseen in the next few years [1]. (who.int)
- Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and insufficient insulin response. (mdpi.com)
- His research focuses on models of inflammation in disease states including neuro-inflammation and metabolic dysfunction/type II diabetes. (nottingham.ac.uk)
- Some ACE inhibitors have been found to slow the process that leads to kidney damage in many people with type 2 diabetes. (cdc.gov)
- When two mutated beta hematohiston fractional monetary units bind to two wild type alpha sub units, formation of a an deviant hemoglobin called HbS takes topographic point. (freebooksummary.com)
Particles2
- Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. (hindawi.com)
- Furthermore, because each LDL particle contains one molecule of apolipoprotein B-100, the majority of apolipoprotein B (apo-B) would indirectly test the number of LDL particles. (hindawi.com)
Ratio1
- [ 2 ] Prior to this analysis, recent studies had shown that the apo B apoA-I ratio was strongly associated with future CAD. (medscape.com)