No data available that match "apicoplasts"


Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. (1/6)

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The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. (2/6)

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The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites. (3/6)

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Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin. (4/6)

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The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. (5/6)

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The apicoplast genome of Leucocytozoon caulleryi, a pathogenic apicomplexan parasite of the chicken. (6/6)

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*Plasmodium

The apicoplast is involved in isoprenoid metabolism, Fe-S cluster synthesis, fatty acid synthesis, and phospholipid ... as well as genetic material in the mitochondrion and in the apicoplast. The chromosomes vary from 500 kilobases to 3.5 ... "The Algal Past and Parasite Present of the Apicoplast". Annual Review of Microbiology. 67: 271-289. doi:10.1146/annurev-micro- ... "The Algal Past and Parasite Present of Apicoplast". Annual Review of Microbiology. 67: 271-289. doi:10.1146/annurev-micro- ...

*Plasmodium

Dooren, Giel; Striepen, Boris (June 26, 2013). "The Algal Past and Parasite Present of the Apicoplast". Annual Review of ... the apicoplast, is derived from a secondary endosymbiosis event, in this case the acquisition of a red algae by the Plasmodium ... the mitochondrion and the apicoplast, both of which play key roles in the parasite's metabolism. Unlike mammalian cells which ... "The apicoplast: Now you see it, now you don't". International Journal for Parasitology. 47 (2-3): 137-144. doi:10.1016/j. ...

*List of sequenced plastomes

Cai X, Fuller AL, McDougald LR, Zhu G (2003). "Apicoplast genome of the coccidian Eimeria tenella". Gene. 321: 39-46. doi: ...

*Эукариоты - Википедия

Kohler S. Multi-membrane-bound structures of Apicomplexa: I. the architecture of the Toxoplasma gondii apicoplast. Parasitol ... New comprehension of the apicoplast of Sarcocystis by transmission electron tomography. Biol Cell. 2006 ...

*Goussia

Apicoplasts are currently being investigated as a potential drug target to treat apicomplexans; due to the fact that it is ... and apicoplasts, which are specialized plastids involved in various synthesis activities carried out by the cell, (Heame, ... lipids etc..). It has been noted that the destruction of the apicoplast does not immediately kill the cell, but it prevents it ... Plasmodium falciparum Apicoplast Drugs: Targets or Off-Targets? Chemical Reviews, 112(3), 1269-1283. https://doi.org/10.1021/ ...

*Chloroplast

Many apicomplexans keep a vestigial red algal derived chloroplast[53][35] called an apicoplast, which they inherited from their ... Apicoplasts have lost all photosynthetic function, and contain no photosynthetic pigments or true thylakoids. They are bounded ... Plant chloroplasts provide plant cells with many important things besides sugar, and apicoplasts are no different-they ... This makes the apicoplast an attractive target for drugs to cure apicomplexan-related diseases.[33] The most important ...

*Cardiosporidium

Like other members of this phylum it possesses apicoplasts, rhoptries and subpellicular microtubules. It is found in the Gulf ...

*Chloroplast

This makes the apicoplast an attractive target for drugs to cure apicomplexan-related diseases. The most important apicoplast ... Apicoplasts have lost all photosynthetic function, and contain no photosynthetic pigments or true thylakoids. They are bounded ... Many apicomplexans keep a vestigial red algal derived chloroplast called an apicoplast, which they inherited from their ... Plant chloroplasts provide plant cells with many important things besides sugar, and apicoplasts are no different-they ...

*Doxycycline

This delay is related to its mechanism of action, which is to specifically impair the progeny of the apicoplast genes, ... "Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum". Antimicrob. Agents Chemother. ...

*Apicomplexa

Most of them possess a unique form of organelle that comprises a type of plastid called an apicoplast, and an apical complex ... Ram, Ev; Naik, R; Ganguli, M; Habib, S (July 2008). "DNA organization by the apicoplast-targeted bacterial histone-like protein ... Another similarity is that many apicomplexan cells contain a single plastid, called the apicoplast, surrounded by either three ... Most apicomplexans have an apicoplast, (a nonphotosynthetic plastid) and mitochondrial and nuclear genomes, although ...

*List of Plasmodium species

Analysis of the apicoplast genes auggests that P. ovale is related to the rodent species. This is consistent with its ... An analysis of four apicoplast genome-encoded genes (small subunit rRNA, large subunit rRNA and caseinolytic protease C) of ... The Plasmodium apicoplast genome: conserved structure and close relationship of P. ovale to rodent malaria parasites. Mol Biol ... based on an analysis of the apicoplast genome, appears to be related to the rodent species suggesting an ancestral host switch ...

*4-Hydroxy-3-methylbut-2-enyl diphosphate reductase

"Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium ...

*DNA gyrase

"Molecular Cloning of Apicoplast-Targeted Plasmodium falciparum DNA Gyrase Genes: Unique Intrinsic ATPase Activity and ATP- ... Gyrase has been found in the apicoplast of the malarial parasite Plasmodium falciparum, a unicellular eukaryote. Bacterial DNA ...

*Apicomplexa - Simple English Wikipedia, the free encyclopedia

They have a unique organelle, a plastid called an apicoplast,[2] and an apical complex structure which gets them into a host's ... Ram, Ev et al (2008). "DNA organization by the apicoplast-targeted bacterial histone-like protein of Plasmodium falciparum". ... Another similarity is that many apicomplexan cells contain a single plastid, called the apicoplast, surrounded by either 3 or ...

*Apicomplexa

Most of them possess a unique form of organelle that comprises a type of plastid called an apicoplast, and an apical complex ... Another similarity is that many apicomplexan cells contain a single plastid, called the apicoplast, surrounded by either three ... Most apicomplexans have an apicoplast, (a nonphotosynthetic plastid) and mitochondrial and nuclear genomes, although ... "DNA organization by the apicoplast-targeted bacterial histone-like protein of Plasmodium falciparum". Nucleic Acids Research ...

*Plastid

... apicoplast' is no longer capable of photosynthesis, but is an essential organelle, and a promising target for antiparasitic ...

*Cytosol

... for instance fatty acid synthesis occurs in chloroplasts in plants and in apicoplasts in apicomplexa. Goodsell DS (June 1991 ...

*Ferredoxin-NADP(+) reductase

These apicoplasts contain plant-like FNRs that the protozoan uses to generate reduced ferredoxin, which is then used as a ... The apicoplast organelle in these organisms is believed to have come from an endosymbiotic event in which an ancestral ...

*Plasmodium inui

January 2010). "Phylogeny of Asian primate malaria parasites inferred from apicoplast genome-encoded genes with special ...

*InterPro

... apicoplasts, non-photosynthetic plastids) proteins families or subfamilies.. MobiDB is a database annotating intrinsic disorder ...

*5S ribosomal RNA

... but also in genomes of certain apicoplasts (non-photosynthetic plastids of pathogenic protozoa such as Toxoplasma gondii and ...

*InterPro

... apicoplasts, non-photosynthetic plastids) proteins families or subfamilies. PANTHER is a large collection of protein families ...

*Floridean starch

... starch-like storage in some apicomplexan parasites is one piece of evidence supporting a red alga ancestry for the apicoplast, ...

*Protist

For example, the apicoplast (a nonphotosynthetic chloroplast but essential to carry out important functions other than ...

*Apicoplast

The apicoplast is surrounded by four membranes within the outermost part of the endomembrane system. Apicoplasts are a relict, ... The functions of apicoplasts have not been conclusively defined. However, it has been established that the apicoplast is a ... This conclusion is supported by the discovery of Type II Fatty Acid Synthase (FAS) machinery in the apicoplast. The apicoplast ... Evidence suggests that the apicoplast is a product of secondary endosymbiosis, and that the apicoplast may be homologous to the ...

*Micronucleus

Micronuclei primarily result from acentric chromosome fragments or lagging whole chromosomes that are not included in the daughter nuclei produced by mitosis because they fail to correctly attach to the spindle during the segregation of chromosomes in anaphase. These full chromosomes or chromatid fragments are eventually enclosed by a nuclear membranes and are structurally similar to conventional nuclei, albeit smaller in size. This small nucleus is referred to as a micronucleus. The formation of micronuclei can only be observed in cells undergoing nuclear division and can be clearly seen using cytochalasin B to block cytokinesis to produce a binucleated cells.[2] Acentric chromosome fragments may arise in a variety of ways. One way is that disrepair of DNA double-strand breaks can lead to symmetrical or asymmetrical chromatid and chromosome exchanges as well as chromatid and chromosome fragments. If DNA damage exceeds the repair capacity of the cell, unrepaired double-stranded DNA breaks may ...
DeRisi and Ellen Yeh, a postdoctoral fellow in his lab, chose to study an apicoplast pathway that hadnt been targeted yet: a set of genes that synthesize isoprenoids, chemical building blocks with a number of cellular functions. DeRisi and Yeh used a known chemical inhibitor to block the isoprenoid pathway in Plasmodiums apicoplasts. The cells died as expected, indicating that the pathway is vital to their survival. The scientists then added the end product of the pathway-a compound called isopentenyl pyrophosphate(IPP)-to Plasmodiumcells at the same time as the pathway-blocking drug. The malaria-causing cells survived this time, demonstrating the importance of IPP to malaria ...
Malaria caused by Plasmodium spp parasites has an enormous disease burden that disproportionately affects the worlds poorest and youngest. Our research focuses on elucidating the biology and function of the parasites unique plastid organelle, the apicoplast, which is a key anti-malarial drug target. We take innovative approaches to meet the challenges of studying this complex organism, including a chemical rescue that generates "mutant" parasites lacking their apicoplasts! Investigation of Plasmodium biology offers both the potential for important global health impact and an opportunity to explore fascinating eukaryotic biology ...
Leucocytozoon caulleryi is a species of the genus Leucocytozoon, a genus of parasitic alveolates. This species has both insect (Culicoides species) and vertebrate (birds) hosts. This species was originally described by Mathis and Leger in 1909. The species was also described by Akiba in Japan in 1958. A second species - Leucocytozoon schufneri - was described by Prowazek in 1912 also in the chicken. This is now considered to be a synonym. This species has been classified into the subgenus Akiba because of its vector: other species in the genus are transmitted by species of the genus Simulium. The parasite is transmitted by the bite of its vector. On infection of a vertebrate host, the parasites enter the blood stream and spread through the body. They invade the endothelial cells in a number of organs. These grow into multinucleated masses - megaloschizonts. This first round of schizonts give rise to the first generation of merozoites. This first generation of merozoites invade new endothelial ...
Summarized supercritical fluid property,supercritical fluid application and supercritical fluid extraction technique. Introduced the present situation that researched in the home and abroad,compendium supercritical fluid technique profit and defect and orientation which will be researched.
A novel algorithm and original software were used to cluster all proteins encoded in plastids of 72 species of the rhodophytic branch. The results are publicly available at http://lab6.iitp.ru/ppc/redline72/ in a database that allows fast identification of clusters (protein families) both by a fragment of an amino acid sequence and by a phylogenetic profile of a protein. No such integral clustering with the corresponding functions can be found in the public domain. The putative regulons of the transcription factors Ycf28 and Ycf29 encoded in the plastids were identified using the clustering and the database. A regulation of translation initiation was proposed for the ycf24 gene in plastids of certain red algae and apicomplexans as well as a regulation of a putative gene in apicoplasts of Babesia spp. and Theileria parva. The conserved regulation of the ycf24 gene expression and specificity alternation of the transcription factor Ycf28 were shown in the plastids. A phylogenetic tree of plastids was
Chromera velia is an autotrophic protist isolated from stony corals. C. velia possesses a chloroplast thought to be most closely related to the apicoplasts of non-photosynthetic apicomplexa. . The ventral side of the flagellated C. velia cell has two grooves extending from the anterior flagella insertion point with a ridge rising towards the anterior apex of the cell. The anterior flagellum is shorter than the posterior flagellum and possesses a distinct, small curved appendage. The insertion point of the anterior flagellum is partly enclosed by a flap extending from the cell. The posterior flagellum is approximately four times the length of the cell and possesses mastigonemes. ...
Targeting of apicoplast replication and protein synthesis in the apicomplexan Toxoplasma gondii has conventionally been associated with the typical "delayed death" phenotype, characterized by the death of parasites only in the generation following drug intervention. We demonstrate that antibiotics like clindamycin, chloramphenicol, and tetracycline, inhibitors of prokaryotic protein synthesis, invoke the delayed death phenotype in Plasmodium falciparum, too, as evident from a specific reduction of apicoplast genome copy number. Interestingly, however, molecules like triclosan, cerulenin, fops, and NAS-91, inhibitors of the recently discovered fatty acid synthesis pathway, and succinyl acetone, an inhibitor of heme biosynthesis that operates in the apicoplast of the parasite, display rapid and striking parasiticidal effects. Our results draw a clear distinction between apicoplast functions per se and the apicoplast as the site of metabolic pathways, which are required for parasite survival, and ...
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Looking for online definition of Leucocytozoon sabrazesi in the Medical Dictionary? Leucocytozoon sabrazesi explanation free. What is Leucocytozoon sabrazesi? Meaning of Leucocytozoon sabrazesi medical term. What does Leucocytozoon sabrazesi mean?
Third Coast Old Ale is a American Barleywine style beer brewed by Bells Brewery, Inc. in Kalamazoo, MI. 4.11 average with 2730 ratings, reviews and opinions.
Most apicomplexan parasites harbor a relict chloroplast, the apicoplast, that is critical for their survival. While the apicoplast maintains a small genome, the bulk of its proteins are nuclear-encoded and imported into the organelle. Several models have been proposed to explain how proteins might cross the four membranes that surround the apicoplast, however experimental data discriminating these models is largely missing. Here we present genetic evidence that apicoplast protein import depends on elements derived from the ER associated protein degradation (ERAD) system of the endosymbiont. We identify two sets of ERAD components in Toxoplasma gondii, one associated with the ER and cytoplasm and one localized to the membranes of the apicoplast. We engineer a conditional null mutant in apicoplast Der1, the putative pore of the apicoplast ERAD complex, and find that loss of Der1Ap results in loss of apicoplast protein import and subsequent death of the parasite ...
The complex Re2(CO)8[-2-C(H)=C(H)Bun](-H), 2.1 reacts with SbPh3 at 68 oC to yield the new σ-phenyl dirhenium complex Re2(CO)8(SbPh3)(Ph)(μ-SbPh2), 2.4 in 72% yield. Compound 2.4 contains two rhenium atoms held together by a bridging SbPh2 ligand. One rhenium atom contains a σ-phenyl group. The other rhenium atom contains a SbPh3 ligand. Compound 2.4 was also obtained in 34% yield from the reaction of Re2(CO)10 with SbPh3 in the presence of UV-vis irradiation together with some monorhenium products: HRe(CO)4SbPh3, 2.5, Re(Ph)(CO)4SbPh3, 2.6 and fac-Re(Ph)(CO)3(SbPh3)2, 2.7 in low yields. Complex 2.4 is split by reaction with an additional quantity of SbPh3 to yield the monorhenium SbPh3 complexes 2.6, 2.7 and mer-Re(Ph)(CO)3(SbPh3)2, 2.8 that contain a σ-phenyl ligand. When 2.4 was treated with hydrogen, the phenyl ligand was eliminated as benzene and the dirhenium complexes Re2(CO)8(μ-SbPh2)(μ-H), 2.10, and Re2(CO)7(SbPh3)(μ-SbPh2)(μ-H), 2.11, were formed that contain a bridging hydrido ligand.
Ivomec Injection for Cattle and Swine dewormer provides protection against internal and external parasites. For the treatment and control of gastrointestinal roundworms, lungworms, sucking lice, mange mites and cattle grubs. Each ml contains 10 mg of ivermectin. Dosage: Cattle - 1 ml subcutaneously
Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.. ...

Yeh LabYeh Lab

Our research focuses on elucidating the biology and function of the parasites unique plastid organelle, the apicoplast, which ... The chemistry and biology of the unique plastid organelle, the apicoplast, in malaria parasites.. ... parasites lacking their apicoplasts! Investigation of Plasmodium biology offers both the potential for important global health ...
more infohttps://yehlab.stanford.edu/

Apicoplast - WikipediaApicoplast - Wikipedia

The apicoplast is surrounded by four membranes within the outermost part of the endomembrane system. Apicoplasts are a relict, ... The functions of apicoplasts have not been conclusively defined. However, it has been established that the apicoplast is a ... This conclusion is supported by the discovery of Type II Fatty Acid Synthase (FAS) machinery in the apicoplast. The apicoplast ... Evidence suggests that the apicoplast is a product of secondary endosymbiosis, and that the apicoplast may be homologous to the ...
more infohttps://en.wikipedia.org/wiki/Apicoplast

RCSB PDB - 2QNW: Toxoplasma gondii apicoplast-targeted acyl carrier proteinRCSB PDB - 2QNW: Toxoplasma gondii apicoplast-targeted acyl carrier protein

Toxoplasma gondii apicoplast-targeted acyl carrier protein.. Lunin, V.V., Wernimont, A., Lew, J., Qiu, W., Lin, L., Hassanali, ...
more infohttps://www.rcsb.org/structure/2qnw

Targeting the apicoplast in malaria | Biochemical Society Transactions | Portland PressTargeting the apicoplast in malaria | Biochemical Society Transactions | Portland Press

We provide an overview of drugs known to inhibit apicoplast pathways, alongside recent findings in apicoplast biology that may ... named the apicoplast. Since humans and animals have no plastids, the apicoplast is an attractive target for drug development. ... Initially, many apicoplast inhibitions were found to result in delayed death, whereby parasite killing is seen only at the ... Marco Biddau, Lilach Sheiner; Targeting the apicoplast in malaria. Biochem Soc Trans 30 August 2019; 47 (4): 973-983. doi: ...
more infohttps://portlandpress.com/biochemsoctrans/article-abstract/47/4/973/219685/Targeting-the-apicoplast-in-malaria

Targeting the apicoplast in malaria | Biochemical Society Transactions | Portland PressTargeting the apicoplast in malaria | Biochemical Society Transactions | Portland Press

We provide an overview of drugs known to inhibit apicoplast pathways, alongside recent findings in apicoplast biology that may ... named the apicoplast. Since humans and animals have no plastids, the apicoplast is an attractive target for drug development. ... Initially, many apicoplast inhibitions were found to result in delayed death, whereby parasite killing is seen only at the ... Marco Biddau, Lilach Sheiner; Targeting the apicoplast in malaria. Biochem Soc Trans 30 August 2019; 47 (4): 973-983. doi: ...
more infohttps://portlandpress.com/biochemsoctrans/article-abstract/47/4/973/219685/Targeting-the-apicoplast-in-malaria?redirectedFrom=fulltext

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.  -...Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. -...

Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as ... Immunoblot using anti-GFP shows a time course of apicoplast-dependent protein processing of apicoplast-targeted GFP in (A) ... rendering them functionally apicoplast-minus. Despite the loss of this essential organelle, these apicoplast-minus auxotrophs ... B) Apicoplast∶nuclear and (C) mitochondria∶nuclear genome ratio of doxycycline only and doxycycline+IPP treated parasites over ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/21912516?dopt=Abstract

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii | JEMApicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii | JEM

The apicoplast is indispensable and an attractive drug target. The apicoplast is home to a 1-deoxy-d-xylulose-5-phosphate (DOXP ... The Toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite ... one localized to the ER and one to the apicoplast (Déchamps et al., 2010). Consumption of G3P in the apicoplast could require ... coli DOXPRI fused to an apicoplast leader (green, L-EcDOXPRI). The apicoplast protein Cpn60 is shown for comparison (blue). (B ...
more infohttp://jem.rupress.org/content/208/7/1547

Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum | ScienceDissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum | Science

Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum. By Bernardo J. Foth, Stuart A. Ralph, ... Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum. By Bernardo J. Foth, Stuart A. Ralph, ... Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum Message Subject. (Your Name) has forwarded a page ... We extracted amino acid features from transit peptides that target proteins to the relict plastid (apicoplast) of malaria ...
more infohttps://science.sciencemag.org/content/299/5607/705

Additional file 2: Figure S2. of Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from...Additional file 2: Figure S2. of Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from...

of Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from diverse geographical regions ... of Comparative sequence analysis of Cyclospora cayetanensis apicoplast genomes originating from diverse geographical regions. ...
more infohttps://figshare.com/articles/Additional_file_2_Figure_S2_of_Comparative_sequence_analysis_of_Cyclospora_cayetanensis_apicoplast_genomes_originating_from_diverse_geographical_regions/4356326/1

Biochemical and structural characterisation of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum  -...Biochemical and structural characterisation of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum -...

Laine, L. M., Biddau, M. , Byron, O. and Müller, S. (2014) Biochemical and structural characterisation of the apicoplast ... Laine, L. M., Biddau, M. , Byron, O. and Müller, S. (2014) Biochemical and structural characterisation of the apicoplast ... Here, P. falciparum apicoplast E3 (PfaE3) was recombinantly expressed and characterised. Biochemical parameters were comparable ... In the human malaria parasite Plasmodium falciparum the single PDC is located exclusively in the apicoplast. Plasmodium PDC is ...
more infohttp://eprints.gla.ac.uk/99237/

Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial...Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial...

The apicoplast and mitochondrial genomes of C. cayetanensis are 34,155 and 6,229 bp in size and code for 65 and 5 genes, ... The apicoplast and mitochondrial genomes of C. cayetanensis are highly similar to those of cecum-infecting avian Eimeria spp. ... The apicoplast genome is circular, codes for the complete machinery for protein biosynthesis, and contains two inverted repeats ... The assembled genomes of the apicoplast and mitochondrion were retrieved, annotated, and compared with reference genomes for ...
more infohttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-0966-3/figures/5

Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. -...Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. -...

Genetic disruption of the apicoplast-localized type II fatty-acid synthase resulted in greatly reduced synthesis of saturated ... Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii.. *Érica S ... Atypical lipid composition in the puri fi ed relict plastid ( apicoplast ) of malaria parasites. *Cyrille Y. Bottéa, Yoshiki ... Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.. @article ...
more infohttps://www.semanticscholar.org/paper/Apicoplast-and-endoplasmic-reticulum-cooperate-in-Ramakrishnan-Docampo/8c695d2c482d916378ff34a2576db3bab897ccf5

The Toxoplasma Blog: Apicoplast: keep it or leave itThe Toxoplasma Blog: Apicoplast: keep it or leave it

Apicoplast: keep it or leave it. Fleige T, Limenitakis J, Soldati-Favre D.. Department of Microbiology and Molecular Medicine, ... Most Apicomplexans possess a relic plastid named apicoplast, originating from secondary endosymbiosis of a red algae. This non- ...
more infohttp://toxoplasmaparasite.blogspot.com/2010/01/apicoplast-keep-it-or-leave-it.html

The Toxoplasma Blog: The apicoplast: a red alga in human parasitesThe Toxoplasma Blog: The apicoplast: a red alga in human parasites

The apicoplast: a red alga in human parasites.. Striepen B.. SourceCenter for Tropical and Emerging Global Diseases and ... The apicoplast is bounded by four membranes, and these membranes trace their ancestry to three different organisms. ... As humans lack chloroplasts, the apicoplast has become one of the prime targets for the development of parasite-specific drugs. ... A remnant of this endosymbiont is still present today, albeit reduced to a small chloroplast-like organelle, the apicoplast. In ...
more infohttp://toxoplasmaparasite.blogspot.com/2011/10/apicoplast-red-alga-in-human-parasites.html

GregarinaGregarina

Apicoplast?. The apicoplast is a remnant, non-photosynthetic homologue to chloroplasts found in many apicomplexan parasites. ... However, apicoplasts appear to be absent altogether in Cryptosporidium (Zhu et al. 2000, Abrahamsen et al. 2004, Xu et al. 2004 ... At that time, apicoplasts had not been discovered. Toso & Omoto (2007) showed by a number of criteria that G. niphandrodes does ... The apicoplast: A review of the derived plastid of apicomplexan parasites. Current Issues in Molecular Biology 7: 57-80. ...
more infohttp://tolweb.org/Gregarina/124806/2008.09.23

Inhibitors of Nonhousekeeping Functions of the Apicoplast Defy Delayed Death in Plasmodium falciparum  - ePrints@IIScInhibitors of Nonhousekeeping Functions of the Apicoplast Defy Delayed Death in Plasmodium falciparum - [email protected]

Our results draw a clear distinction between apicoplast functions per se and the apicoplast as the site of metabolic pathways, ... Targeting of apicoplast replication and protein synthesis in the apicomplexan Toxoplasma gondii has conventionally been ... Inhibitors of Nonhousekeeping Functions of the Apicoplast Defy Delayed Death in Plasmodium falciparum ... an inhibitor of heme biosynthesis that operates in the apicoplast of the parasite, display rapid and striking parasiticidal ...
more infohttp://eprints.iisc.ernet.in/9660/

CAPi: Computational Model for Apicoplast Inhibitors PredictiCAPi: Computational Model for Apicoplast Inhibitors Predicti

Discovery of apicoplast as a drug target offers a new direction in the development of novel anti-malarial compounds, especially ... Background: Discovery of apicoplast as a drug target offers a new direction in the development of novel anti-malarial compounds ... Therefore, in this study, we developed a computational model to predict apicoplast inhibitors by applying state-of-the-art ... Drugs such as azithromycin were reported to block the apicoplast development that leads to unusual phenotypes affecting the ...
more infohttp://www.currentcomputeraideddrugdesign.com/articles/150566/capi-computational-model-for-apicoplast-inhibitors-prediction-against-plasmodium-parasite

Indirect aminoacylation in the Plasmodium apicoplast - Malcolm GardnerIndirect aminoacylation in the Plasmodium apicoplast - Malcolm Gardner

Apicoplast-targeting of two subunits of P. falciparum glutamyl-tRNA amidotransferase was detected by transfection of parasites ... In addition, recombinant apicoplast glutamyl-tRNA synthetase expressed in wheat germ exhibited both discriminating and non- ... 2015) Plasmodium Apicoplast Gln-tRNAGln Biosynthesis Utilizes a Unique GatAB Amidotransferase Essential for Erythrocytic Stage ... Indirect aminoacylation in the Plasmodium apicoplast Gardner, Malcolm John Seattle Biomedical Research Institute, Seattle, WA, ...
more infohttp://grantome.com/grant/NIH/R21-AI081097-02

Welcome to CDC stacks | Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in...Welcome to CDC stacks | Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in...

The apicoplast and mitochondrial genomes of C. cayetanensis are 34,155 and 6,229 bp in size and code for 65 and 5 genes, ... The apicoplast and mitochondrial genomes of C. cayetanensis are highly similar to those of cecum-infecting avian Eimeria spp. ... The apicoplast genome is circular, codes for the complete machinery for protein biosynthesis, and contains two inverted repeats ... The assembled genomes of the apicoplast and mitochondrion were retrieved, annotated, and compared with reference genomes for ...
more infohttps://stacks.cdc.gov/view/cdc/32102/Share

A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its...A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its...

We further show that the U1-lactone treatment resulted in formation of abnormal apicoplasts which were not able to grow and ... We further show that the U1-lactone treatment resulted in formation of abnormal apicoplasts which were not able to grow and ... Overall, our data show that the PfClpP protease has confirmed localization in the apicoplast and it plays important role in ... Overall, our data show that the PfClpP protease has confirmed localization in the apicoplast and it plays important role in ...
more infohttps://kops.uni-konstanz.de/handle/123456789/28442

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparumApicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum

... ... Biosynthesis of LA exclusively occurs in the apicoplast, comprising octanoyl-[acyl carrier protein]: protein N- ... Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum PLoS Pathogens , vol. 3 , no. 12 , e189 , ... apicoplast-located pyruvate dehydrogenase still showed lipoylation, suggesting that an alternative lipoylation pathway exists ...
more infohttps://research-repository.st-andrews.ac.uk/handle/10023/4242

Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast - Semantic ScholarCharacterization of acyl carrier protein and LytB in Babesia bovis apicoplast - Semantic Scholar

To specifically compare apicoplast pathways between parasites that have both common and unique stages, we characterized the ... Despite structural conservation of the apicoplast among different parasite genera and species, there are also critical ... to the apicoplast, and demonstrated that the N-terminal bipartite signals of both proteins are required and sufficient for ... The results indicate specialized molding of apicoplast biosynthetic pathways to meet the requirements of individual ...
more infohttps://www.semanticscholar.org/paper/Characterization-of-acyl-carrier-protein-and-LytB-Caballero-Pedroni/f1eba444967eb5dbb41d3a431680c0dbe8c6b28b

Comparative genomic analysis and phylogenetic position of Theileria equi | BMC Genomics | Full TextComparative genomic analysis and phylogenetic position of Theileria equi | BMC Genomics | Full Text

The apicoplast. The apicoplast is a plastid-like organelle thought to be derived from a secondary endosymbiotic event with ... equi, the A+T rich (71%) 47.8 kb apicoplast genome is larger than those of other piroplasms, due primarily to expansion of the ... equi apicoplast genome gene arrangement, showing unidirectional coding of genes. Known enzymes shown in red, ribosomal proteins ... equi contains six molecules, including four chromosomes (Figure1) of ~11.6 Mbp, an apicoplast genome of 47.8 kbp and a ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-603
  • We take innovative approaches to meet the challenges of studying this complex organism, including a chemical rescue that generates "mutant" parasites lacking their apicoplasts! (stanford.edu)
  • In addition, recombinant apicoplast glutamyl-tRNA synthetase expressed in wheat germ exhibited both discriminating and non-discriminating activity by glutamylating apicoplast tRNAGlu and tRNAGln, an essential property of tRNA synthetases that participate in indirect aminoacylation pathways in bacteria and plastids. (grantome.com)
  • Maximum likelihood phylogeny of apicoplast ( a ) and mitochondrial ( b ) genomes. (biomedcentral.com)
  • Distinct differences in the apicoplast genomes of C. cayetanensis could be useful in designing advanced molecular methods for rapid detection and, subtyping and geographical source attribution, which would aid outbreak investigations and surveillance studies. (cdc.gov)
  • Indeed, after its discovery, the apicoplast was found to host the target pathways of some known antimalarial drugs, which motivated efforts for further research into its biological functions and biogenesis. (portlandpress.com)
  • We provide an overview of drugs known to inhibit apicoplast pathways, alongside recent findings in apicoplast biology that may provide new avenues for drug development. (portlandpress.com)
  • Over 500 proteins are predicted to localize to this organelle and several prokaryotic biochemical pathways have been annotated, yet the essential role of the apicoplast during human infection remains a mystery. (nih.gov)
  • Three major anabolic pathways have been identified in the apicoplast: a type II fatty acid synthesis (FASII) pathway, a 1-deoxy- d -xylulose-5-phosphate (DOXP) pathway for the synthesis of isoprenoid precursors, and a portion of the heme biosynthetic pathway. (rupress.org)
  • Our results draw a clear distinction between apicoplast functions per se and the apicoplast as the site of metabolic pathways, which are required for parasite survival, and thus subserve the development of novel antimalarial therapy. (iisc.ernet.in)
  • Because apicoplasts are vital to parasite survival, they provide an enticing target for antimalarial drugs. (wikipedia.org)
  • Despite the loss of photosynthesis, the apicoplast is critical for the survival of apicomplexans. (rupress.org)
  • Overall, our data show that the PfClpP protease has confirmed localization in the apicoplast and it plays important role in development of functional apicoplasts. (uni-konstanz.de)
  • Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. (nih.gov)
  • The functions of apicoplasts have not been conclusively defined. (wikipedia.org)
  • This conclusion is supported by the discovery of Type II Fatty Acid Synthase (FAS) machinery in the apicoplast. (wikipedia.org)
  • Background: Discovery of apicoplast as a drug target offers a new direction in the development of novel anti-malarial compounds, especially against the drug-resistant strains. (currentcomputeraideddrugdesign.com)
  • The apicoplast is bounded by four membranes, and these membranes trace their ancestry to three different organisms. (blogspot.com)
  • Specifically, apicoplasts' plant-like properties provide a target for herbicidal drugs. (wikipedia.org)
  • Initially, many apicoplast inhibitions were found to result in 'delayed death', whereby parasite killing is seen only at the end of one invasion-egress cycle. (portlandpress.com)
  • The apicoplast is also thought to have a role in isoprenoid synthesis, which are prosthetic groups on many enzymes and also act as precursors to ubiquinones (involved in electron transport) and dolichols (involved in glycoprotein formation). (wikipedia.org)
  • Surprisingly, IPP supplementation also completely reverses death following treatment with antibiotics that cause loss of the apicoplast. (nih.gov)
  • Furthermore, herbicides may be able to specifically target the parasite's plant-like apicoplast and without any noticeable effect on the mammalian host's cells. (wikipedia.org)