AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
Aphasia, Primary ProgressiveAphasiaPrimary Progressive Nonfluent AphasiaMultiple Sclerosis, Chronic ProgressiveAnomiaAphasia, BrocaLanguage TestsAgraphiaAtrophyMultiple Sclerosis, Relapsing-RemittingApraxia, IdeomotorSpeechApraxiasMultiple SclerosisNeuropsychological TestsSpeech TherapySemanticsAphasia, ConductionFrontotemporal DementiaLanguage DisordersMagnetic Resonance ImagingSpeech DisordersAphasia, WernickeBrainFrontotemporal Lobar DegenerationLanguageAcid Sensing Ion Channel BlockersTemporal LobePick Disease of the BrainLanguage TherapyDisease ProgressionNeuroimagingDementiaEcholaliaVerbal BehaviorDiffusion Tensor ImagingComprehensionFrontal LobeBrain MappingAlzheimer DiseaseRemission, SpontaneousMental Status ScheduleFunctional LateralityImage Processing, Computer-AssistedNeurologic ExaminationCerebral CortexSeverity of Illness IndexDisability EvaluationCognition DisordersCase-Control StudiesAniline CompoundsAge of OnsetSpinal CordImage Interpretation, Computer-AssistedPositron-Emission TomographyDyslexia, AcquiredNerve Fibers, MyelinatedSpeech Production MeasurementLinguisticsNerve DegenerationStatistics, NonparametricStrokeNerve NetSupranuclear Palsy, ProgressiveRecurrencePsychomotor PerformanceNamesTomography, X-Ray Computed
Aphasia, Primary Progressive
A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Aphasia
A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.
Primary Progressive Nonfluent Aphasia
A form of frontotemporal lobar degeneration and a progressive form of dementia characterized by motor speech impairment and AGRAMMATISM, with relative sparing of single word comprehension and semantic memory.
Multiple Sclerosis, Chronic Progressive
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
Anomia
A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)
Aphasia, Broca
An aphasia characterized by impairment of expressive LANGUAGE (speech, writing, signs) and relative preservation of receptive language abilities (i.e., comprehension). This condition is caused by lesions of the motor association cortex in the FRONTAL LOBE (BROCA AREA and adjacent cortical and white matter regions).
Language Tests
Tests designed to assess language behavior and abilities. They include tests of vocabulary, comprehension, grammar and functional use of language, e.g., Development Sentence Scoring, Receptive-Expressive Emergent Language Scale, Parsons Language Sample, Utah Test of Language Development, Michigan Language Inventory and Verbal Language Development Scale, Illinois Test of Psycholinguistic Abilities, Northwestern Syntax Screening Test, Peabody Picture Vocabulary Test, Ammons Full-Range Picture Vocabulary Test, and Assessment of Children's Language Comprehension.
Agraphia
Loss or impairment of the ability to write (letters, syllables, words, or phrases) due to an injury to a specific cerebral area or occasionally due to emotional factors. This condition rarely occurs in isolation, and often accompanies APHASIA. (From Adams et al., Principles of Neurology, 6th ed, p485; APA, Thesaurus of Psychological Index Terms, 1994)
Atrophy
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Multiple Sclerosis, Relapsing-Remitting
The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914)
Apraxia, Ideomotor
A form of apraxia characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)
Speech
Communication through a system of conventional vocal symbols.
Apraxias
A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Neuropsychological Tests
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Speech Therapy
Treatment for individuals with speech defects and disorders that involves counseling and use of various exercises and aids to help the development of new speech habits.
Semantics
The relationships between symbols and their meanings.
Aphasia, Conduction
A type of fluent aphasia characterized by an impaired ability to repeat one and two word phrases, despite retained comprehension. This condition is associated with dominant hemisphere lesions involving the arcuate fasciculus (a white matter projection between Broca's and Wernicke's areas) and adjacent structures. Like patients with Wernicke aphasia (APHASIA, WERNICKE), patients with conduction aphasia are fluent but commit paraphasic errors during attempts at written and oral forms of communication. (From Adams et al., Principles of Neurology, 6th ed, p482; Brain & Bannister, Clinical Neurology, 7th ed, p142; Kandel et al., Principles of Neural Science, 3d ed, p848)
Frontotemporal Dementia
The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.
Language Disorders
Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.
Magnetic Resonance Imaging
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Speech Disorders
Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.
Aphasia, Wernicke
Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Frontotemporal Lobar Degeneration
Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
Language
A verbal or nonverbal means of communicating ideas or feelings.
Acid Sensing Ion Channel Blockers
A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.
Temporal Lobe
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
Pick Disease of the Brain
A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
Language Therapy
Rehabilitation of persons with language disorders or training of children with language development disorders.
Disease Progression
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Neuroimaging
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
Dementia
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
Echolalia
Involuntary ("parrot-like"), meaningless repetition of a recently heard word, phrase, or song. This condition may be associated with transcortical APHASIA; SCHIZOPHRENIA; or other disorders. (From Adams et al., Principles of Neurology, 6th ed, p485)
Verbal Behavior
Includes both producing and responding to words, either written or spoken.
Diffusion Tensor Imaging
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
Comprehension
The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.
Frontal Lobe
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
Brain Mapping
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Remission, Spontaneous
A spontaneous diminution or abatement of a disease over time, without formal treatment.
Mental Status Schedule
Standardized clinical interview used to assess current psychopathology by scaling patient responses to the questions.
Functional Laterality
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Image Processing, Computer-Assisted
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Neurologic Examination
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
Cerebral Cortex
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Severity of Illness Index
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Disability Evaluation
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
Cognition Disorders
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Aniline Compounds
Age of Onset
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
Spinal Cord
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Image Interpretation, Computer-Assisted
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Positron-Emission Tomography
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Dyslexia, Acquired
A receptive visual aphasia characterized by the loss of a previously possessed ability to comprehend the meaning or significance of handwritten words, despite intact vision. This condition may be associated with posterior cerebral artery infarction (INFARCTION, POSTERIOR CEREBRAL ARTERY) and other BRAIN DISEASES.
Nerve Fibers, Myelinated
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
Speech Production Measurement
Measurement of parameters of the speech product such as vocal tone, loudness, pitch, voice quality, articulation, resonance, phonation, phonetic structure and prosody.
Linguistics
The science of language, including phonetics, phonology, morphology, syntax, semantics, pragmatics, and historical linguistics. (Random House Unabridged Dictionary, 2d ed)
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Statistics, Nonparametric
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Nerve Net
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
Supranuclear Palsy, Progressive
A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
Recurrence
The return of a sign, symptom, or disease after a remission.
Psychomotor Performance
The coordination of a sensory or ideational (cognitive) process and a motor activity.
Names
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
Tomography, X-Ray Computed
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Primary progressive aphasia : a case report. (1/119)

Primary progressive aphasia is due to focal left perisylvian degeneration and manifests with progressive decline in language function for two or more years. There is preservation of cognitive functions and activities of daily living continue to be normal. We report a case of progressive aphasia in a 65 year old lady.  (+info)

Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases. (2/119)

There has been increasing awareness that some slowly progressive focal cortical syndromes can be the presenting features of Alzheimer's disease, but pathological evidence has been sparse. This clinico-pathological series presents our experience with pathologically proven atypical as well as typical Alzheimer's disease presentations. We report and compare four patterns of presentation: a typical pattern with initial amnesic syndrome (n = 4 cases), progressive visual dysfunction (n = 1), progressive biparietal syndrome (n = 2) and progressive aphasia (n = 6). The aphasic presentations include both fluent and non-fluent aphasic syndromes. The neuropsychological profiles and neuroimaging clearly reflect the presenting clinical features, and show a close relationship to the distribution of pathology in these cases. Of note was the sparing of medial temporal structures (hippocampus and/or entorhinal cortex) in several aphasic cases and the severe occipito-parietal involvement in those with prominent visuospatial disorders at presentation. Our data demonstrate the wide spectrum of Alzheimer's disease presentations. The recognition of atypical presentations of Alzheimer's disease is important when attempting to make an early accurate pre-morbid diagnosis of neurodegenerative disease.  (+info)

Frontotemporal decreases in rCBF correlate with degree of dysnomia in primary progressive aphasia. (3/119)

Primary progressive aphasia (PPA) is an uncommon degenerative dementia characterized by gradual impairment of language function with initial sparing of the memory domain. Using semiquantitative 99mTc-hexamethyl propyleneamine oxime (HMPAO) brain SPECT as a measure of regional cerebral blood flow (rCBF), we investigated the relationship between reduced 99mTc-HMPAO uptake and the severity of dysnomia in PPA. METHODS: Seven right-handed patients with PPA had their dysnomia assessed by the Boston Naming Test (BNT), a subtest of the Boston Diagnostic Aphasia Examination. Neuroimaging studies, including 99mTc-HMPAO brain SPECT, CT, and MRI, were performed. Correlational analysis between reduced rCBF and BNT was performed. RESULTS: Brain SPECT showed a reduction in 99mTc-HMPAO uptake involving the frontal and temporal lobes in all 7 patients. CT and MRI showed mild to moderate cerebral atrophy in 4 patients. Low scores on the BNT correlated with low frontotemporal 99mTc-HMPAO (Spearman r = 0.97, P = 0.004) in the 5 patients with left-hemisphere involvement. CONCLUSION: Decreased rCBF to the frontotemporal region characterized the cerebral abnormalities associated with PPA. The finding of focal rCBF abnormalities in the right hemisphere of 2 right-handed women corroborates that PPA symptoms may arise from a "non-left-dominant"-hemisphere degenerative process. Our results support the usefulness of rCBF SPECT imaging as a diagnostic aid in PPA.  (+info)

The role of conceptual knowledge in object use evidence from semantic dementia. (4/119)

It has been reported that patients with semantic dementia function well in everyday life and sometimes show striking preservation of the ability to use objects, even those specific objects for which the patient has degraded conceptual information. To explore this phenomenon in nine cases of semantic dementia, we designed a set of semantic tests regarding 20 everyday objects and compared performance on these with the patients' ability to demonstrate the correct use of the same items. We also administered a test of mechanical problem solving utilizing novel tools, on which the patients had completely normal ability. All but the mildest affected patient showed significant deficits of naming and on the visually based semantic matching tasks. Object use was markedly impaired and, most importantly, correlated strongly with naming and semantic knowledge. In a small number of instances, there was appropriate use of an object for which the patient's knowledge on the semantic matching tasks was no better than chance; but this typically applied to objects with a rather obvious relationship between appearance and use, or was achieved by trial and error. The results suggest that object use is heavily dependent upon object-specific conceptual knowledge, supplemented to some degree by a combination of visual affordances and mechanical problem solving.  (+info)

Primary progressive aphasia: analisys of 16 cases. (5/119)

Primary progressive aphasia (PPA) is an intriguing syndrome, showing some peculiar aspects that differentiate it from classical aphasic pictures caused by focal cerebral lesions or dementia. The slow and progressive deterioration of language occurring in these cases provides an interesting model to better understand the mechanisms involved in the linguistic process. We describe clinical and neuroimaging aspects found in 16 cases of PPA. Our patients underwent language and neuropsychological evaluation, magnetic resonance imaging (MRI) and single photon emission computerized tomography (SPECT). We observed a clear distinction in oral expression patterns; patients were classified as fluent and nonfluent. Anomia was the earliest and most evident symptom in both groups. Neuroimaging pointed to SPECT as a valuable instrument in guiding the differential diagnosis, as well as in making useful clinical and anatomical correlations. This report and a comparison to literature are an attempt to contribute to a better understanding of PPA.  (+info)

Evidence of bilateral temporal lobe involvement in primary progressive aphasia: a SPECT study. (6/119)

Primary progressive aphasia (PPA) is rare. Only limited series have been reported with SPECT or PET. Moreover, in the majority of studies, the left-to-right asymmetry ratio was used, leading to difficulties in right hemisphere analyzes. METHODS: Twenty-nine patients with clinical criteria of PPA (Mesulam and Weintraub) were included and compared with 12 control subjects. Complete language examination was performed in all patients. SPECT was performed on a double-head gamma camera after intravenous injection of hexamethylpropyleneamine oxime (22 patients and 12 control subjects) or ethylcysteinate dimer (7 patients). Nineteen regions of interest (ROIs) were drawn on each hemisphere in all patients using the Talairach atlas. The perfusion index (PI = cortex-to-cerebellum ratio) was calculated for each ROI. Atrophy was quantified on MRI by consensus of 3 observers in 16 cortical ROIs. ANOVAs were used to compare the PI between (a). patients and control subjects, (b). patients with (n = 15) or without (n = 14) lexicosemantic abnormalities (LS+ vs. LS-) and patients with (n = 19) or without (n = 10) arthric disorders (A+ vs. A-), and (c). patients with or without atrophy. RESULTS: In the 29 patients, the PI was significantly lower in the left temporopolar, left lateral temporal, left Wernicke, left parietal, and right lateral temporal cortex when compared with control subjects (P < 0.001). In LS+ patients versus control subjects, the PI significantly decreased in the left temporal cortex (lateral temporal; medial temporal; temporopolar; Wernicke), left Broca, left parietal, and right lateral temporal cortex (P < 0.001). In addition, LS+ versus LS- comparison showed a significant decrease in the left lateral, left medial temporal, and left Broca cortex (P < 0.001). In comparison with control subjects, the PI was not significantly different in A+ patients, whereas in A- patients the PI was significantly decreased in the left and right lateral temporal cortex, left Wernicke, and left parietal cortex. Moreover, the PI significantly decreased in the left lateral temporal region in A+ patients compared with A- patients. Finally, in patients without atrophy, the PI significantly decreased in the right and left lateral temporal cortex and the left parietal cortex (P < 0.01). CONCLUSION: Our study demonstrates that right-handed patients with PPA present a decreased perfusion in the bilateral temporal cortex. Moreover, in these regions, morphologic abnormalities are preceded by perfusion abnormalities. Finally, our results show that large left temporal dysfunction occurs in patients with LS disorders.  (+info)

Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. (7/119)

Progressive non-fluent aphasia (PNFA) is a syndrome in which patients lose the ability to communicate fluently in the context of relative preservation of single word comprehension and non-linguistic cognitive abilities. Neuroimaging in case studies with PNFA has failed to identify a consistent neural substrate for the language disorder. In this study of a group of patients (n=10) whose presenting complaint was progressive dysfluency, resting cerebral metabolism was measured using [18F]fluorodeoxyglucose-PET and analysed with the technique of statistical parametric mapping (SPM). Regional atrophy was assessed with voxel-based morphometry (VBM). Seven patients had a 'pure' PNFA syndrome, while the remaining three had additional features of a more pervasive dementia. Compared with controls, the patients showed hypometabolism in several regions that, most notably, included the left anterior insula/frontal opercular region. The VBM analysis revealed only one small area of atrophy in the left peri-Sylvian region. Analysis of the pure PNFA cases (n=7) relative to controls yielded qualitatively similar results to those of the whole group, suggesting that these cases were also at risk of a more generalized dementia, a finding borne out in subsequent follow-up of two cases to date. The PNFA group was then compared with a group with Alzheimer's disease (n=10) whose clinical profile did not include non-fluent aphasic features. In this analysis, the only persisting hypometabolic region was that centred over the left anterior insula. VBM did not identify any regional differences in atrophy between PNFA and Alzheimer's disease. In the light of current theories of fluent language production, the findings offer anatomical evidence that the breakdown in fluency is due to a motor articulatory planning deficit (speech apraxia) combined with a variable degree of agrammatism.  (+info)

Cognition and anatomy in three variants of primary progressive aphasia. (8/119)

We performed a comprehensive cognitive, neuroimaging, and genetic study of 31 patients with primary progressive aphasia (PPA), a decline in language functions that remains isolated for at least 2 years. Detailed speech and language evaluation was used to identify three different clinical variants: nonfluent progressive aphasia (NFPA; n = 11), semantic dementia (SD; n = 10), and a third variant termed logopenic progressive aphasia (LPA; n = 10). Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. However, when each clinical variant was considered separately, distinctive patterns emerged: (1) NFPA, characterized by apraxia of speech and deficits in processing complex syntax, was associated with left inferior frontal and insular atrophy; (2) SD, characterized by fluent speech and semantic memory deficits, was associated with anterior temporal damage; and (3) LPA, characterized by slow speech and impaired syntactic comprehension and naming, showed atrophy in the left posterior temporal cortex and inferior parietal lobule. Apolipoprotein E epsilon4 haplotype frequency was 20% in NFPA, 0% in SD, and 67% in LPA. Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes.  (+info)

Primary progressive aphasia | B-health blogPrimary progressive aphasia | B-health blog
Primary progressive aphasia is a rare neurological syndrome that impairs language capabilities. People with primary progressive aphasia may have trouble naming objects or may misuse word endings, verb tenses, conjunctions and pronouns. People with primary progressive aphasia can become mute and may eventually lose the ability to understand written or spoken language. Primary progressive aphasia is a type of frontotemporal dementia, a cluster of related disorders that all originate in the frontal or temporal lobes of the brain.. Primary progressive aphasia specifically targets the language center of the brain - located in the brains left hemisphere. Brain scans typically show a marked shrinkage of the brains language center in people who have primary progressive aphasia. Brain activity also can be diminished.. Symptoms of primary progressive aphasia begin gradually, usually before the age of 65, and tend to worsen over time. Symptoms may vary by individual, depending on which portion of the ...
http://bhealthblog.com/primary-progressive-aphasia/
Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia with the Neuropathology of FTLD-TDP...
TY - JOUR. T1 - Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia with the Neuropathology of FTLD-TDP Type A. AU - Mesulam, Marek-Marsel. AU - Nelson, Matthew J.. AU - Hyun, Jungmoon. AU - Rader, Benjamin. AU - Hurley, Robert S.. AU - Rademakers, Rosa. AU - Baker, Matthew C.. AU - Bigio, Eileen H. AU - Weintraub, Sandra. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Four patients with primary progressive aphasia displayed a greater deficit in understanding words they heard than words they read, and a further deficiency in naming objects orally rather than in writing. All four had frontotemporal lobar degeneration-Transactive response DNA binding protein Type A neuropathology, three determined postmortem and one surmised on the basis of granulin gene (GRN) mutation. These features of language impairment are not characteristic of any currently recognized primary progressive aphasia variant. They can be operationalized as manifestations of dysfunction centered on a ...
https://www.scholars.northwestern.edu/en/publications/preferential-disruption-of-auditory-word-representations-in-prima
Examining the value of lexical retrieval treatment in primary progressive aphasia: Two positive cases<...
TY - JOUR. T1 - Examining the value of lexical retrieval treatment in primary progressive aphasia. T2 - Two positive cases. AU - Henry, M. L.. AU - Rising, K.. AU - DeMarco, A. T.. AU - Miller, B. L.. AU - Gorno-Tempini, M. L.. AU - Beeson, P. M.. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Individuals with primary progressive aphasia (PPA) suffer a gradual decline in communication ability as a result of neurodegenerative disease. Language treatment shows promise as a means of addressing these difficulties but much remains to be learned with regard to the potential value of treatment across variants and stages of the disorder. We present two cases, one with semantic variant of PPA and the other with logopenic PPA, each of whom underwent treatment that was unique in its focus on training self-cueing strategies to engage residual language skills. Despite differing language profiles and levels of aphasia severity, each individual benefited from treatment and showed maintenance of gains as well as ...
https://arizona.pure.elsevier.com/en/publications/examining-the-value-of-lexical-retrieval-treatment-in-primary-pro
What is Primary progressive aphasia (PPA)? | Doctor Dementia and the Dementia AdventureWhat is Primary progressive aphasia (PPA)? | Doctor Dementia and the Dementia Adventure
This information comes to us from The Association for Frontotemporal Degeneration. Logopenic variant Primary Progressive Aphasia Primary progressive aphasia (PPA) is a language disorder that involves changes in the ability to speak, read, write and understand what others are saying. It is associated with a disease process that causes atrophy in the frontal and temporal…
https://doctordementia.com/2016/01/13/what-is-primary-progressive-aphasia-ppa/
Primary progressive aphasia: A 25-year retrospective<...
TY - JOUR. T1 - Primary progressive aphasia. T2 - A 25-year retrospective. AU - Mesulam, Marek-Marsel. PY - 2007/10/1. Y1 - 2007/10/1. N2 - The diagnosis of primary progressive aphasia (PPA) is made in any patient in whom a language impairment (aphasia), caused by a neurodegenerative disease (progressive), constitutes the most salient aspect of the clinical picture (primary). The language impairment can be fluent or nonfluent and may or may not interfere with word comprehension. Memory for recent events is relatively preserved although memory scores obtained in verbally mediated tests may be abnormal. Lesser changes in behavior and object recognition may be present but are not the leading factors that bring the patient to medical attention. This selective clinical pattern is most conspicuous in the initial stages of the disease. Progressive nonfluent aphasia and some types of semantic dementia can be considered subtypes of PPA. Initially brought to the attention of contemporary literature 25 ...
https://www.scholars.northwestern.edu/en/publications/primary-progressive-aphasia-a-25-year-retrospective
Naming and comprehension in primary progressive aphasia: The influence of grammatical word class<...
TY - JOUR. T1 - Naming and comprehension in primary progressive aphasia. T2 - The influence of grammatical word class. AU - Hillis, Argye E.. AU - Heidler-Gary, Jennifer. AU - Newhart, Melissa. AU - Chang, Shannon. AU - Ken, Lynda. AU - Bak, Thomas H.. PY - 2006/2/1. Y1 - 2006/2/1. N2 - Background: Various clinical types of primary progressive aphasia have been associated with distinct areas of atrophy and pathological changes. Therefore, differences in the patterns of language deterioration in the various types might reveal the types of language processes and representations that depend on the areas of brain that are disproportionately affected. Aims: To test the hypotheses (1) that individuals with progressive nonfluent aphasia (associated with left posterior, inferior frontal, and insular atrophy) show progressive motor speech impairment and disproportionate deterioration in naming actions relative to objects, and (2) that individuals with semantic dementia (associated with anterior and ...
https://jhu.pure.elsevier.com/en/publications/naming-and-comprehension-in-primary-progressive-aphasia-the-influ-5
The Ravel case; possible link between non fluent Primary Progressive Aphasia and basal ganglia dysfunction | Atlas of ScienceThe Ravel case; possible link between non fluent Primary Progressive Aphasia and basal ganglia dysfunction | Atlas of Science
The Primary Progressive Aphasia (PPA) syndrome was firstly introduced in 1982. Recently, the primary progressive aphasias were classified into three clinical variants; non fluent/agrammatic, semantic and logopenic.
http://atlasofscience.org/the-ravel-case-possible-link-between-non-fluent-primary-progressive-aphasia-and-basal-ganglia-dysfunction/
Speech and language therapy approaches to managing primary progressive aphasia | Practical NeurologySpeech and language therapy approaches to managing primary progressive aphasia | Practical Neurology
The term primary progressive aphasia (PPA) describes a group of neurodegenerative disorders with predominant speech and language dysfunction as their main feature. There are three main variants - the semantic variant, the nonfluent or agrammatic variant and the logopenic variant - each with specific linguistic deficits and different neuroanatomical involvement. There are currently no curative treatments or symptomatic pharmacological therapies. However, speech and language therapists have developed several impairment-based interventions and compensatory strategies for use in the clinic. Unfortunately, multiple barriers still need to be overcome to improve access to care for people with PPA, including increasing awareness among referring clinicians, improving training of speech and language therapists and developing evidence-based guidelines for therapeutic interventions. This review highlights this inequity and the reasons why neurologists should refer people with PPA to speech and language ...
https://pn.bmj.com/content/20/2/154?rss=1
One cat, two cats, red cat, blue cats: eliciting morphemes from individuals with primary progressive aphasiaOne cat, two cats, red cat, blue cats: eliciting morphemes from individuals with primary progressive aphasia
ABSTRACTBackground: Progressive neurodegenerative impairment with central language features, primary progressive aphasia (PPA), can be further distinguished for many individuals into one of three variants: semantic, non-fluent/agrammatic, and logopenic variant PPA. ...
https://freepaper.me/downloads/abstract/10.1080/02687038.2020.1852167
PapersPapers
PDF. Thompson, C.K., Cho, S., Hsu, C.J., Wieneke, C., Weitner, B.B., Mesulam, M.M., & Weintraub, S. (2012). Dissociation between fluency and agrammatism in Primary Progressive Aphasia. Aphasiology, 26(1), 20-43. PMC3244141.. Mesulam, M.M., Wieneke, C., Thompson, C.K., Rogalski, E., & Weintraub, S. (2012). Quantitative classification of Primary Progressive Aphasia at early and mild impairment stages. Brain, 135(5), 1537-1553. PMC3577099.. Thompson, C.K., Cho, S., Price, C., Wieneke, C., Bonakdarpour, B., Weintraub, S., & Mesulam, M.M. (2012). Semantic interference during object naming in agrammatic and logopenic Primary Progressive Aphasia (PPA). Brain and Language, 120, 237-250. PMC3299898.. Rogalski, E., Cobia, D., Harrison, T.M., Wieneke, C., Thompson, C.K., Weintraub, S., & Mesulam, M.-M. (2011). Anatomy of language impairments in Primary Progressive Aphasia. Journal of Neruoscience, 31(9), 3344-3350. PMC3112000.. Hurley, R.S., Paller, K.A., Wieneke, C.A., Weintraub, S., Thompson, C.K., ...
http://anr.northwestern.edu/research/papers/
A recreation therapy twist to sign language: an intervention for primary progressive aphasia., NC DOCKS (North Carolina Digital...
Abstract: This thesis examines the feasibility of the ASL for Active Living Program as an intervention for clinical practice among individuals with memory loss and/or aphasia with associated depression. It strives to answer the following questions: First will an eight session RT intervention impact on symptoms of depression in individuals with mild memory loss and aphasia? Second, will participation in this intervention change levels of self-esteem? Third, to what extent will the older adult participants be able to learn and retain finger-spelling and vocabulary taught? Lastly, will participants be satisfied with this type of intervention? The first chapter reports the current trends of an aging society, as well as the increase in co-morbid disorders such as depression. The second chapter provides a thorough literature review which clearly identifies Mild Cognitive Impairment and Primary Progressive Aphasia as well as describes efficacy studies that provide the foundation for this study. The ...
http://libres.uncg.edu/ir/listing.aspx?id=3703
Language in Primary Progressive Aphasia - Full Text View - ClinicalTrials.govLanguage in Primary Progressive Aphasia - Full Text View - ClinicalTrials.gov
The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.. During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), an MRI (a non-invasive brain-imaging procedure), an EEG (another non-invasive procedure that looks at brain waves when you think) and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.. The study will recruit approximately 15 participants with PPA per year. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study. ...
https://clinicaltrials.gov/ct2/show/NCT00537004?cond=%22Semantic+dementia%22&rank=7
Identification of an atypical variant of logopenic progressive aphasia<...
TY - JOUR. T1 - Identification of an atypical variant of logopenic progressive aphasia. AU - Machulda, Mary Margaret. AU - Whitwell, Jennifer Lynn. AU - Duffy, Joseph R.. AU - Strand, Edythe A.. AU - Dean, Pamela M.. AU - Senjem, Matthew L.. AU - Jack, Clifford R Jr.. AU - Josephs, Keith Anthony. PY - 2013/11. Y1 - 2013/11. N2 - The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long ...
https://mayoclinic.pure.elsevier.com/en/publications/identification-of-an-atypical-variant-of-logopenic-progressive-ap
Most recent papers with the keyword Primary progressive aphasia | Read by QxMDMost recent papers with the keyword Primary progressive aphasia | Read by QxMD
Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimers disease (AD). 18 F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between 18 F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4 ...
https://www.readbyqxmd.com/keyword/12085
Determinants of Neurodegenerative Decline in Primary Progressive Aphasia - Emily RogalskiDeterminants of Neurodegenerative Decline in Primary Progressive Aphasia - Emily Rogalski
Primary progressive aphasia (PPA) is a clinical dementia syndrome caused by neurodegenerative brain disease, with language impairment as the primary feature. Al...
http://grantome.com/grant/NIH/R01-NS075075-03
Rare Dementia, Primary Progressive Aphasia, Attacks Brains Language Center - The New York TimesRare Dementia, Primary Progressive Aphasia, Attacks Brains Language Center - The New York Times
Primary progressive aphasia is one of several forms of brain disease lost in the medical shadow of a much better known relative, Alzheimers disease.
http://www.nytimes.com/2011/05/03/health/03brody.html?ref=personalhealth&pagewanted=all&_r=0
Aphasia Affects Brain Similar to Alzheimers, But Without Memory LossAphasia Affects Brain Similar to Alzheimers, But Without Memory Loss
WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...
https://healthlibrary.stamfordhealth.org/RelatedItems/6,1649792504
Aphasia Affects Brain Similar to Alzheimers, But Without Memory Loss
WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...
https://healthresources.copcp.com/Wellness/MentalHealth/6,1649792504
Aphasia Affects Brain Similar to Alzheimers, But Without Memory LossAphasia Affects Brain Similar to Alzheimers, But Without Memory Loss
WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...
https://betterhealth.saintpetershcs.com/RelatedItems/6,1649792504
The logopenic/phonological variant of primary progressive aphasia | NeurologyThe logopenic/phonological variant of primary progressive aphasia | Neurology
We defined the neuropsychological and imaging features of the logopenic variant of PPA that in our experience represents 30% of all PPA cases. Our results suggested that the core cognitive deficit in LPA was a phonological loop disorder. Consistently, the imaging investigation showed involvement of GM and WM in the left posterior temporal and inferior parietal regions.. LPA is characterized by a decreased rate of spontaneous language production with frequent halts due to word-finding pauses. Phonemic paraphasias are common, but motor speech and grammar are spared. This pattern of language production is different from the fast output typical of early SemD patients, who usually fill word-finding pauses with circumlocutions and filler words. It is also distinct from the production deficit typical of PNFA, in which articulation deficits and agrammatism predominate.22 LPA patients, therefore, show a pattern of intermediate fluency distinct from the fluent SemDs and the nonfluent PNFAs, raising the ...
https://n.neurology.org/content/71/16/1227?ijkey=6ef5c9d7c5bd8f9b61e488cd8e4ee1b8b078d563&keytype2=tf_ipsecsha
Rareshare
The signs and symptoms for frontotemporal dementia varies from one individual to another. It can easily be mistaken for a psychiatric disorder. Identifying the disease in an individual can be a challenge for the scientists and doctors. Frontotemporal dementia is generally broken down into three subgroups - a behavioral variant and two forms of primary progressive aphasia, the nonfluent variant and the semantic variant.. The behavioral variant is characterized by personality changes, a lack of restraint toward social conventions or behaviors (disinhibition), and a general lack of interest, enthusiasm or concern (apathy). This is the most common subtype of frontotemporal dementia.. Primary progressive aphasia is characterized by the slow onset and gradual progression of language difficulties. Individuals may have difficulty finding the right word or understanding certain words in written or spoken speech. The nonfluent variant is characterized by slow, deliberate, sometimes halting speech ...
https://rareshare.org/communities/frontotemporal-dementia?news_link_direction=asc&news_link_sort=title&resource_direction=asc&resource_sort=title
AAN Annual Meeting Programs: C132 - Frontotemporal Dementias | American Academy of Neurology®
Frontotemporal dementias are a group of disorders featuring progressive decline in behavior or language, with neurodegeneration of the frontal or temporal lobes. In this session, faculty will highlight current diagnostic and management approaches for the most common subtypes of frontotemporal dementia: behavioural variant FTD, nonfluent primary progressive aphasia, and semantic variant primary progressive aphasia. Recent developments in neuroimaging, genetics, and biomarkers related to FTD will be highlighted. Through case presentations, practical approaches to the assessment and management of patients with FTD symptoms will be discussed, including discussion of related disorders that can mimic FTD ...
https://tools.aan.com/annualmeeting/search/index.cfm?fuseaction=home.detail&id=7058&keyword=&topic=80,80,80,80&type=all
Most recent papers with the keyword Agrammatic variant | Read by QxMDMost recent papers with the keyword Agrammatic variant | Read by QxMD
Although commonly interpreted as a marker of episodic memory during neuropsychological exams, relatively little is known regarding the neurobehavior of total learning immediate recall scores. Medial temporal lobes are clearly associated with delayed recall performances, yet immediate recall may necessitate networks beyond traditional episodic memory. We aimed to operationalize cognitive and neuroanatomic correlates of total immediate recall in several aging syndromes. Demographically-matched neurologically normal adults (n=91), individuals with Alzheimers disease (n=566), logopenic variant primary progressive aphasia (PPA) (n=34), behavioral variant frontotemporal dementia (n=97), semantic variant PPA (n=71), or nonfluent/agrammatic variant PPA (n=39) completed a neurocognitive battery, including the CVLT-Short Form trials 1-4 Total Immediate Recall; a majority subset also completed a brain MRI ...
https://www.readbyqxmd.com/keyword/29091
The Brain Clock Blog: Rare Dementia, Primary Progressive Aphasia, Attacks Brains Language Center - NYTimes.comThe Brain Clock Blog: Rare Dementia, Primary Progressive Aphasia, Attacks Brains Language Center - NYTimes.com
AC (29) ADHD (30) affect (1) aging (22) Alzheimers (3) American Indians (1) anterior cinglate (1) APA (1) aphasia (5) apraxia (3) Aspergers (1) ATI (1) attention (56) attentional control (32) auditory (14) Auditory Neuroscience Lab (2) autism (6) automatic timing (8) background noise (1) basal ganglia (16) beat perception (4) beat production (4) biofeedback (1) book nook (21) BPR3 (1) brain structures (24) brain beat (1) brain carnival (34) brain clock (122) Brain Clock Blog (2) brain clock timing (2) brain facts (2) brain fitness (119) brain function (3) brain injury (25) brain location (28) Brain network integration (1) brain network segregation (1) brain networks (57) brain rhythm (20) brain structure (1) brain teasers (2) brain timing (1) brain training (14) brainstem (2) BRAMS lab (1) Brocas area (1) caffeine (1) CAPD (2) CAT (1) CBRM (1) cerebellum (17) cerebral palsy (2) CHC (1) CHC theory (11) CHC videos (1) circadian (4) classification (1) clinical disorders (3) clocks (1) CNTRICS (1) ...
http://ticktockbraintalk.blogspot.com/2011/05/rare-dementia-primary-progressive.html
Frontotemporal networks and behavioral symptoms in primary progressive aphasia | NeurologyFrontotemporal networks and behavioral symptoms in primary progressive aphasia | Neurology
TrackVis was used to perform the virtual in vivo dissection of the 3 tracts of interest according to previously published methods.6,20,-,25 Tractography dissections were obtained using manually defined ROIs on the orthogonal fractional anisotropy images. The following tracts were dissected as previously described.7,21. The uncinate fasciculus is a U-shaped bundle that arises in the temporal pole, lateral to the parahippocampal gyrus and amygdala. In the temporal lobe, the uncinate fasciculus is ventral to the inferior fronto-occipital fasciculus. Arching forward, the uncinate then enters the external capsule and splits into a ventrolateral and an anteromedial branch.7 The ventrolateral component ends in the anterior insula and lateral orbitofrontal cortex, while the anteromedial branch reaches the olfactory cortex, the medial orbitofrontal cortex, and the frontal pole.7 Dissections of the uncinate fasciculus were performed by placing a ROI in the anterior temporal lobe and a second ROI in the ...
https://n.neurology.org/content/86/15/1393?ijkey=0fc8fd70099ca84c6d905709ce9d8a10f1a011fc&keytype2=tf_ipsecsha
DMOZ - Health: Conditions and Diseases: Neurological Disorders: Dementia: Primary Progressive Aphasia
A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions.
http://dmoztools.net/Health/Conditions_and_Diseases/Neurological_Disorders/Dementia/Primary_Progressive_Aphasia/
Primary progressive aphasia Archives - Progressive Radio NetworkPrimary progressive aphasia Archives - Progressive Radio Network
Researchers from the University of Louisville say their latest study confirms gut bacteria play a role in the development of neurodegenerative diseases. Neurodegenerative diseases such as Parkinsons disease, amyotropic lateral sclerosis, and Alzheimers disease are characterized by misfolded proteins and inflammation of the brain. Scientists say they are unsure about the causes of 90 percent of cases recorded. In the ...
https://prn.fm/tag/primary-progressive-aphasia/
RPBG Speech Pathology launches Primary Progressive Aphasia Therapy GroupRPBG Speech Pathology launches Primary Progressive Aphasia Therapy Group
Speech Pathology Week (25 - 31 August) seeks to promote the work done by speech pathologists with the more than 1.2 million Australians who have a communication disability which impacts on daily life.
https://bhs.health.wa.gov.au/About-us/News/RPBG-Speech-Pathology-launches-Primary-Progressive-Aphasia-Therapy-Group
Primary progressive aphasia Archives | Alzheimers Research UKPrimary progressive aphasia Archives | Alzheimers Research UK
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
https://www.alzheimersresearchuk.org/dementia-type/primary-progressive-aphasia/
Classification of primary progressive aphasia and its variants
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC3059138/?lang=en-ca
Diagnosis and treatment - Mayo ClinicDiagnosis and treatment - Mayo Clinic
Family members eventually may need to consider long-term care options for the person with primary progressive aphasia. Family members may also need to plan the persons finances and help make legal decisions to prepare for more-serious stages of the condition.. Support groups may be available for you and the person with primary progressive aphasia or related conditions. Ask your social worker or other members of your treatment team about community resources or support groups.. ...
https://www.mayoclinic.org/diseases-conditions/primary-progressive-aphasia/diagnosis-treatment/drc-20350504?p=1
Marta Balagué answers questions about her lecture on the update in the diagnosis of primary progressive aphasiasMarta Balagué answers questions about her lecture on the update in the diagnosis of primary progressive aphasias
Marta Balagué, neuropsicologa clínica con más de 15 años de experiencia en el diagnóstico neuropsicológico en el campo de procesos neurodegenerativos,
https://blog.neuronup.com/en/marta-balague-answers-questions-about-primary-progressive-aphasias/
Slowly progressive aphasia: three cases with language, memory, CT and PET data. | Journal of Neurology, Neurosurgery &...Slowly progressive aphasia: three cases with language, memory, CT and PET data. | Journal of Neurology, Neurosurgery &...
Three cases of slowly progressive speech and language disturbance were studied at various points post onset (three, five and 15 years respectively). Language, neuropsychological and brain imaging (computer tomography and positron emission tomography) evaluations were completed on all three patients. The data suggest that the syndrome of progressive aphasia: 1) does not involve a uniform symptom complex; 2) does not necessarily develop into a full blown dementia syndrome; 3) varies greatly in rate of progression from case to case; 4) is associated with normal brain structure (on computer tomography); and 5) is associated with abnormal left temporal lobe metabolism as measured by fluorodeoxyglucose (FDG) positron emission tomography (PET). One patient had histological findings consistent with Alzheimers disease at necropsy.. ...
http://jnnp.bmj.com/content/53/11/987
Early-onset Alzheimers disease - WikipediaEarly-onset Alzheimers disease - Wikipedia
Alzheimers disease (AD) is the most common cause of dementia and usually occurs in old age. It is invariably fatal, generally within ten years of the first signs. Early signs of AD include unusual memory loss, particularly in remembering recent events and the names of people and things, logopenic primary progressive aphasia. As the disease progresses the patient exhibits more serious problems, becoming subject to mood swings and unable to perform complex activities such as driving. In the latter stages they forget how to do simple things such as brushing their hair and then require full-time care.. Histologically, familial AD is practically indistinguishable from other forms of the disease. Deposits of amyloid can be seen in sections of brain tissue. This amyloid protein forms plaques and neurofibrillary tangles that progress through the brain. Very rarely the plaque may be unique, or uncharacteristic of AD; this can happen when there is a mutation in one of the genes that creates a functional, ...
https://en.wikipedia.org/wiki/Early-onset_Alzheimer_disease
Mark A. Gluck and Paul Reber Report on Memory Disorders Meeting | ALZFORUMMark A. Gluck and Paul Reber Report on Memory Disorders Meeting | ALZFORUM
The meeting of the Memory Disorders Research Society in Chicago, held 9-11 October, opened with a session on two neurodegenerative syndromes: primary progressive aphasia (PPA) and semantic dementia (SD). Each of these syndromes bears some resemblance to the progression of Alzheimers disease, but with the key difference that memory is not initially impaired in these patients. Marsel Mesulam of Northwestern University, Evanston, Illinois, began with a characterization of the progression of PPA. In this disease, patients initially have difficulties in basic language functions such as finding names for objects or comprehending speech. These deficits are associated with brain damage occurring in the left hemisphere in perisylvian regions that looks at the cellular level somewhat similar to the damage associated with Alzheimers disease (Mesulam, 2001; Sobrido et al., 2003). John Hodges of the University of Cambridge presented a discussion of SD. Patients with this syndrome initially have difficulty ...
http://www.alzforum.org/news/conference-coverage/mark-gluck-and-paul-reber-report-memory-disorders-meeting
Language comprehension in humans more complicated than previously thought - Experts paper
A probe conducted on the brain by researchers at the Northwestern University suggests that the long-held belief that Wernickes area is the prime area of language comprehension might not be accurate. Marek-Marsel Mesulam, lead probe author and director of Northwesterns Cognitive Neurology and Alzheimers Disease Center, performed language tests and brain MRIs on 72 patients with a uncommon form of language-affecting dementia called primary progressive aphasia (PPA) in which Wernickes area is bruised. He observed that these patients did not exhibit the same trouble with word meaning as stroke victims with similar brain harm. PPA and stroke harm the brain differently; in PPA, cortical areas degenerate, but their underlying fiber pathways that are necessary for communication inbetween different language centers in the brain, remain intact. However, stroke damages large regions of brain. According to Mesulam, this strongly indicates that language comprehension is a sophisticated process that ...
http://expertspaper.biz/2017/12/17/language-comprehension-in-humans-more-complex-than/
SearchSearch
A personality and behavioral disorder is an important and defining feature of frontal lobe dementia (FLD) or frontotemporal degeneration (FTD). The diagnosis usually depends on the progressive development of various behavioral symptoms rather than a set of neuropsychological measures. Quantification of the personality-behavior disorder is important for standardizing the diagnosis. An inventory was constructed to capture the major positive and negative behaviors and personality change, and it was administered prospectively to caregivers of 108 patients in a cognitive neurology clinic, at the time of first diagnostic assessment. The prevalence and extent of behavioral abnormality was quantitated in the clinic population of FLD, vascular dementia (VaD), Alzheimers disease (AD), primary progressive aphasia (PPA), and depressive disorder (DD) patients. The mean scores of FLD patients were significantly above all other groups. Scores in VaD were also higher than in AD, PPA, and DD. Interrater ...
http://core-cms.prod.aop.cambridge.org/core/search?filters%5BauthorTerms%5D=WILDA%20DAVIDSON&eventCode=SE-AU
Publications | Page 3 | Cervo Brain Research CentrePublications | Page 3 | Cervo Brain Research Centre
J. Macoir, Lavoie, M., Laforce, R., Brambati, S. M., and Wilson, M. A., Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria., J Geriatr Psychiatry Neurol, vol. 30, no. 3, pp. 151-161, 2017. ...
https://cervo.ulaval.ca/en/publications?page=2&%3Bamp%3Bf%5Bauthor%5D=3254&%3Bf%5Bauthor%5D=3379&f%5Bauthor%5D=404
SF Site News » HealthSF Site News » Health
Former Monty Python member Terry Jones, who also co-directed Monty Python and the Holy Grail and directed Monty Pythons Life of Brian and The Meaning of Life, has been diagnosed with primary progressive aphasia. Because the disease impacts his ability to communicate, Jones is no longer giving interviews and may eventually lead to complete inability to speak. In addition to his work with Monty Python, Jones has written several documentaries and books on history as well as the novelization of Douglas Adamss video game Starship Titanic ...
https://www.sfsite.com/news/category/health/page/2/
Verb transformation in non-fluent progressive aphasia - Research Portal | Lancaster University
Find out more about Lancaster Universitys research activities, view details of publications, outputs and awards and make contact with our researchers.
http://www.research.lancs.ac.uk/portal/en/publications/verb-transformation-in-nonfluent-progressive-aphasia
FDA Approves Genentechs OCREVUS™ (Ocrelizumab) for Relapsing and Primary Progressive Forms of Multiple Sclerosis | EON:...
Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today that the U.S. Food and Drug Administration (FDA) approved OCREVUS
https://www.enhancedonlinenews.com/news/eon/20170328006580/en
Rituxan Fails PPMS TrialRituxan Fails PPMS Trial
Terrible news for those of us suffering from primary progressive. Im beyond words... http://biz.yahoo.com/bw/080414/20080414006526.html?.v=1
http://www.thisisms.com/forum/general-discussion-f1/topic5399.html
FTY 720 Trial for PPMS Shaping Up?FTY 720 Trial for PPMS Shaping Up?
Does anyone know if Novartis has published the protocol for the arm of the FTY 720 study involving primary progressive patients? Where I can look it up? The trial should start recruiting in January so surely the information is somewhere! ...
http://www.thisisms.com/forum/drug-pipeline-f13/topic4832.html
Bibliotecas UA catalog › Details for: The effects of a combined neurolinguistic intervention for primary progressive aphasia
Autor: Cadório, Inês Ribeiro (1989-)Autor secundário: Figueiredo, Daniela Maria Pias de;Lousada, Marisa Lobo (1980-);Martins, Paula Maria Vaz (1966-)Autor Institucional (Secundário): Universidade de Aveiro. Departamento de Educação e Psicologia.Língua: Inglês.País: Portugal.Publicação: Aveiro : I. Cadório, 2020Descrição: 1 CD-ROMDescrição: XXIV, 176 p. : il. colorTítulo paralelo: Eficácia de uma abordagem integrada de intervenção neurolinguística na afasia progressiva primáriaAssunto : Psicologia da saúde -- Teses de doutoramento // Neurolinguística // Afasia // Qualidade de vida // Novas tecnologiasCDU: 159.95(043)Recursos em linha:Formato digital ...
https://opac.ua.pt/cgi-bin/koha/opac-detail.pl?biblionumber=299064
ALZFORUM | NETWORKING FOR A CUREALZFORUM | NETWORKING FOR A CURE
Mahoney CJ, Downey LE, Beck J, Liang Y, Mead S, Perry RJ, Warren JD. The Presenilin 1 P264L Mutation Presenting as non-Fluent/Agrammatic Primary Progressive Aphasia ...
http://www.alzforum.org/papers/presenilin-1-p264l-mutation-presenting-non-fluentagrammatic-primary-progressive-aphasia
Apraxia of speech: An overview<...
TY - JOUR. T1 - Apraxia of speech. T2 - An overview. AU - Ogar, Jennifer. AU - Slama, Hilary. AU - Dronkers, Nina. AU - Amici, Serena. AU - Gorno-Tempini, Maria Luisa. PY - 2005/12. Y1 - 2005/12. N2 - Apraxia of speech (AOS) is a motor speech disorder that can occur in the absence of aphasia or dysarthria. AOS has been the subject of some controversy since the disorder was first named and described by Darley and his Mayo Clinic colleagues in the 1960s. A recent revival of interest in AOS is due in part to the fact that it is often the first symptom of neurodegenerative diseases, such as primary progressive aphasia and corticobasal degeneration. This article will provide a brief review of terminology associated with AOS, its clinical hallmarks and neuroanatomical correlates. Current models of motor programming will also be addressed as they relate to AOS and finally, typical treatment strategies used in rehabilitating the articulation and prosody deficits associated with AOS will be ...
https://ucdavis.pure.elsevier.com/en/publications/apraxia-of-speech-an-overview
Multiple Sclerosis News for Primary Progressive MS (PPMS) | HubPagesMultiple Sclerosis News for Primary Progressive MS (PPMS) | HubPages
I think the most difficult news to share, is the news for those who find themselves with the most disabling form of MS, the primary progressive sufferers. Unfortunately, this group may be the most under-served of the MS Community simply because...
https://hubpages.com/health/Multiple-Sclerosis-News-for-Primary-Progressive-MS-PPMS
Resources on Stroke & Aphasia - Stroke a Chord Choir
Aphasia Registry - Opportunities to take part in Aphasia research.. Aphasia & Stroke Caregivers Guide - A range of US articles on Aphasia related topics.. Atrial Fibrillation Association (Australia) - Provides information, support and access to established, new or innovative treatments for Atrial Fibrillation. Australian Aphasia Association - Their official website.. Australian Aphasia Guide - 2011 Version available through the National Library of Australia. Books on Aphasia - Books available on line for purchase at The Book Depository (Free Shipping).. Build Your Own Aphasia Talk: Increasing Community Awareness of Aphasia - This resource was developed by Latrobe University in conjunction with the Australian Aphasia Association, it aims to address the poor community awareness of the condition aphasia.. Centre for Clinical Research Excellence (CCRE) in Aphasia Rehabilitation - A new Australia-wide research program on Aphasia.. Communication Problems Following a Stroke - Fact Sheet from Speech ...
http://strokeachord.com/research/resources-on-stroke-aphasia/
Naming and Knowing Revisited: Eyetracking Correlates of Anomia in Progressive AphasiaNaming and Knowing Revisited: Eyetracking Correlates of Anomia in Progressive Aphasia
Progressive naming impairment (i.e., anomia) is a core diagnostic symptom of numerous pathologies that impact anterior and inferior portions of the temporal lobe. For patients who experience such regional temporal lobe degeneration, patterns of language loss often parallel the degradation of semantic memory, an etiology of naming impairment known as semantic anomia. Previous studies of semantic anomia have focused extensively on the output of naming attempts by contrasting errors, omissions, and distortions as a function of item-level characteristics (e.g., prototypicality, semantic category). An alternative approach involves evaluating visual confrontation naming as the naming process unfolds. Techniques with high temporal resolution (e.g., eyetracking) offer a potentially sensitive mode of delineating the locus of impairment during naming. For example, a lexical retrieval disorder would hypothetically elicit normal gaze patterns associated with successful visual object recognition regardless ...
https://scholarshare.temple.edu/handle/20.500.12613/166
Unscramble aphasia | Words unscrambled from letters aphasia | Scrabble Word aphasia | Words Made with the Letters aphasiaUnscramble aphasia | Words unscrambled from letters aphasia | Scrabble Word aphasia | Words Made with the Letters aphasia
Unscramble aphasia, Unscramble letters aphasia, Point value for aphasia, Word Decoder for aphasia, Word generator using the letters aphasia, Word Solver aphasia, Possible Scrabble words with aphasia, Anagram of aphasia
http://www.allscrabblewords.com/word-description/aphasia
Rare Dementia, Main Progressive Aphasia, Attacks Brains Language Center - meet with style
Insurance businesses are urging greater use of read significantly more recycled components to reduce fees. Insurance carriers have a strict discipline with their contracted repair shops, stated Joseph M. Holsten, the chief executive of LKQ Inc., a Chicago-primarily based chain of parts recyclers. He said that if a car was 3 or far more model years old, insurers may well want repair shops to examine the price tag of a recycled component with the cost of a new part.Automobile manufacturing is one particular of the largest industries in the manufacturing sector. If youre interested in importing automobiles or car components with no paying import duties or taxes, you need to have to be conscious that not all persons are eligible to import a vehicle tax free. If you are eligible for a tax totally free auto, this guide will give you step-by-step information on how to import the vehicle and save money.As soon as she took the vehicle house, Travadi said she noticed an oil spot on her driveway from ...
http://epifaniamorin047.wikidot.com/blog:51
Aphasia Center Merchandise! - Aphasia Center of California - Aphasia Center of CaliforniaAphasia Center Merchandise! - Aphasia Center of California - Aphasia Center of California
In honor of National Aphasia Awareness month in June, the Aphasia Center of California has aphasia t-shirts, totes, and masks available for purchase at our online store. Our t-shirt has printing on both the front (got aphasia?) and back (aphasia definition) of the t-shirt, so you will be raising aphasia awareness wherever you go! Items will ship direct to you - even internationally. Help us continue to spread the word and raise aphasia awareness! Heres a link to our online store: https://www.bonfire.com/store/aphasia-center. ...
http://www.aphasiacenter.net/aphasia-center-merchandise/
Aphasia NYC Blogger: What is Aphasia? | Types of Aphasia | Causes of Aphasia
Aphasia usually results from lesions to the language-relevant areas of the temporal and parietal cortex of the brain, such as Brocas area, Wernickes area, and the neural pathways between them. These areas are almost always located in the left hemisphere, and in most people this is where the ability to produce and comprehendlanguage is found. However, in a very small number of people, language ability is found in the right hemisphere. In either case, damage to these language areas can be caused by a stroke, traumatic brain injury, or other brain injury. Aphasia may also develop slowly, as in the case of a brain tumor or progressive neurological disease, e.g., Alzheimers or Parkinsons disease. It may also be caused by a sudden hemorrhagic event within the brain. Certain chronic neurological disorders, such as epilepsy or migraine, can also include transient aphasia as a prodromal or episodic symptom. Aphasia is also listed as a rare side effect of the fentanyl patch, an opioid used to control ...
http://aphasia-nyc.blogspot.com/2010/01/what-is-aphasia-types-of-aphasia-causes.html
Aphasia Reconnect | Public EngagementAphasia Reconnect | Public Engagement
Aphasia Reconnect is a peer support network for people with aphasia.. We work in partnership with people with aphasia to promote inclusion, participation, and community, transforming lives by bringing people with aphasia together and creating opportunities to re-engage with life after stroke.. Aphasia can have a profound impact on every aspect of life. Everyday activities such as taking part in conversation, answering the phone or replying to an email or letter can suddenly become a source of profound frustration and anxiety, leaving people feeling isolated and unable to participate in life. This has perhaps never been more true than now. Our continuing support in the form of physical and virtual groups and one-to-one phone buddies continue to provide a lifeline for people struggling with a life turned inside out, offering peer support, friendship, community and opportunity to hundreds of people with aphasia.. Our volunteers include people with aphasia, as well as people looking toward speech ...
https://engagement.fil.ion.ucl.ac.uk/projects/ucl-world-stroke-day/groups/aphasia-reconnect/
ICD-9-CM Diagnosis Code 010.83 : Other primary progressive tuberculosis, tubercle bacilli found (in sputum) by microscopyICD-9-CM Diagnosis Code 010.83 : Other primary progressive tuberculosis, tubercle bacilli found (in sputum) by microscopy
Free, official info about 2015 ICD-9-CM diagnosis code 010.83. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
http://www.icd9data.com/2015/Volume1/001-139/010-018/010/010.83.htm
Looking for ideas - Primary progressive MS - ForumLooking for ideas - Primary progressive MS - Forum
my mobility is limited, i am able to slide to a wheelchair with folding armrest, i cannot lift my body off the bed, i cannot move my legs on my own, have to use hands, financially not so sound to hire a caregiver and par…
https://forum.mssociety.org.uk/t/looking-for-ideas/36663
Circulation Booster V3 trial - Primary progressive MS - ForumCirculation Booster V3 trial - Primary progressive MS - Forum
Greetings folks. Had a try of a Circulation Booster & was very impressed. So impressed, Ive just purchased one myself from Ebay for £50. I sat with my feet on the pads for half an hour & felt like Id walked for 2 hou…
https://forum.mssociety.org.uk/t/circulation-booster-v3-trial/11756
Doctor Discussion Guide: What to Ask About Primary Progressive MSDoctor Discussion Guide: What to Ask About Primary Progressive MS
When its time to talk with your doctor about PPMS, you may feel overwhelmed. Find out what you should ask - and how to move forward after your appointment.
https://www.healthline.com/health/multiple-sclerosis/primary-progressive-ms/doctor-discussion-guide-what-to-ask
Comment] Does intensity matter in aphasia rehabilitation? - doctorportal | doctorportal
Aphasia is a serious acquired communication disability, that affects approximately 30% of stroke survivors.1 It is chronic in nature: 50% of people diagnosed with aphasia have persistent communication problems 1 year after stroke.2 Aphasia compromises an individuals ability to undertake many activities of daily living, resulting in reduced mood and quality of life.3,4 In addition to the personal cost of aphasia, health-care costs for people with aphasia are the highest in stroke care.5 Therefore, the recent identification of recovery from aphasia as one of the top ten research priorities related to life after stroke is unsurprising.. ...
https://www.doctorportal.com.au/comment-does-intensity-matter-in-aphasia-rehabilitation/
Aphasia Access Conversations
Aphasia Access Conversations brings you the latest aphasia resources, tips and a-ha moments from Life Participation professionals who deliver way more than stroke and aphasia facts. Topics include: aphasia group treatment ideas, communication access strategies, plus ways for growing awareness and funds for your group aphasia therapy program. ​This podcast is produced by Aphasia Access.
https://aphasiaaccess.libsyn.com/2019/
Med Speech Voice & Swallow Center What is aphasia and what causes it? - Med Speech Voice & Swallow CenterMed Speech Voice & Swallow Center What is aphasia and what causes it? - Med Speech Voice & Swallow Center
Aphasia is an acquired language disorder that is caused by damage to the language centers of the brain. Various types of aphasia exist and the damage can be caused by numerous factors. Injury to the language centers of the brain is most commonly caused by stroke, but can also be caused by blows to the head, gunshot/knife wounds, brain tumor, and other sources of traumatic brain injury. Most people, especially those who are right-hand dominant (right-handed), will acquire aphasia if they receive brain injury to the left side of the brain. However, for some people, the right side of the brain houses the language centers; therefore, right side damage may also result in aphasia. Individuals who have acquired aphasia may have been able to read, write, speak, and listen very effectively before injury to their brain, and are now limited in their ability to do so. READ MORE. ...
http://www.med-speech.com/faqs/what-is-aphasia-and-what-causes-it/
Aphasia Conversation Group | New Hanover Regional Medical Center | Wilmington, NCAphasia Conversation Group | New Hanover Regional Medical Center | Wilmington, NC
Aphasia is a language disorder caused by damage to the area of the brain that controls language expression and comprehension often the result of a stroke. If you have been diagnosed with aphasia, we invite you to join our weekly Aphasia Conversation Group. Here people with Aphasia and their caregivers can find a place to share thoughts, frustrations and successes with others facing similar challenges. These interactions also offer you the chance to gain the confidence and support necessary to move forward with recovery.. Aphasia Support Group Flyer. ...
https://www.nhrmc.org/events/intranet/support-groups-and-classes/aphasia-conversation-group?esk=nov+11
Voices of Inspiration Gala, a Free Virtual Event - Adler Aphasia CenterVoices of Inspiration Gala, a Free Virtual Event - Adler Aphasia Center
Please join us for a virtual evening of celebration of the aphasia community, Voices of Inspiration Gala. We will highlight our members and caregivers as they share the impact the Adler Aphasia Center continues to have on their lives. You will also have an opportunity to view an exclusive interview on how Adler has made an impact in New Jersey with Emmy® Award-winning Anchor, Steve Adubato, Ph.D., and NJ Senator Loretta Weinberg from the very comfort of your home.. The Adler Aphasia Center continues to be a lifeline for people with aphasia and their families and we remain grateful for the role we have played in their lives. For over a year we have been offering virtual communication groups four days a week for our members and numerous support groups for our caregivers, as a result of the pandemic. Additionally, we now offer virtual groups for others with aphasia throughout the US who are not enrolled in our Center. Staff continue to stay in touch with all Center members and their families via ...
https://adleraphasiacenter.org/events/annual-gala-2/
Aphasia Camp Committee | Sea to Sky Aphasia CampAphasia Camp Committee | Sea to Sky Aphasia Camp
The Sea to Sky Aphasia Camp Committee is made up of members from UBC, Douglas College, March of Dimes and the community. The Committee is represented by both healthcare professionals and people with aphasia to ensure that the Sea to Sky Aphasia Camp meets the needs of those living with aphasia in the community.
http://www.seatoskyaphasiacamp.com/students/aphasia-camp-committee/
National Aphasia Awareness Month is this Month, learn more
Aphasia is when you have a language disorder after a brain injury. This can affect all aspects of a childs language, like thinking of right words, using correct grammar when talking or writing and understanding what they are hearing or reading. The most common way of getting aphasia is a stroke. You can also develop Aphasia after traumatic brain injury, brain tumors, and other diseases that may cause Aphasia. Depending on the brain damage and amount, the urgency of each problem is different. If
https://www.kidscures.org/single-post/2018/05/31/national-aphasia-awareness-month-is-this-month-learn-more
I have Aphasia Archives - Page 5 of 48 - National Aphasia AssociationI have Aphasia Archives - Page 5 of 48 - National Aphasia Association
Aphasia is challenging, isolating, and frustrating. Here you can find information to help you better understand aphasia, typical treatments, and assistive technology options. You are not alone: over one million people in the U.S. have aphasia.
https://www.aphasia.org/category/i-have-aphasia/page/5/
Aphasia Communication Tips - National Aphasia AssociationAphasia Communication Tips - National Aphasia Association
Communication Strategies: Some Dos and Donts. The impact of aphasia on relationships may be profound, or only slight. No two people with aphasia are alike with respect to severity, former speech and language skills, or personality.
https://www.aphasia.org/aphasia-resources/communication-tips/?gclid=CjwKEAjw4vzKBRCt9Zmg8f2blgESJADN5fDgHciBivZgA-jqnMoPhHpUHa2XoU_Ju48ivaR1-vSEVRoCu-Hw_wcB
How many words made out of AphasiasHow many words made out of Aphasias
List of words make out of Aphasias. Anagrams of word Aphasias. Words made after scrabbling Aphasias. Word Creation helps in Anagrams and Puzzles.
https://wordcreation.info/how-many-words-made-out-of-aphasias.html
Using The Client Resources (Working Together Series) - Aphasia InstituteUsing The Client Resources (Working Together Series) - Aphasia Institute
From our series Working Together To Help You Where You Live, this pictographic resource is designed to facilitate a conversational partnership between health care practitioners and people with aphasia. It is also ideal for people with limited English language skills. It is based on the techniques of Supported Conversation for Adults with Aphasia™ (SCA™), developed by the Aphasia Institute.. We have included three resources in this package:. I Want to Talk To. I Want to Talk About. Important Health Contact Numbers. The I Want to Talk to resource helps identify a potential conversational partner.. The I Want to Talk About resource helps identify a potential conversational topic.. The Important Health Contact Numbers resource includes spaces to note the numbers for specific health care providers. There are also numbers listed for Ontario resources including the following:. ...
https://www.aphasia.ca/shop/client-resources/?add-to-cart=1023
Aphasia Institute: ShopAphasia Institute: Shop
From our series Working Together To Help You Where You Live, this pictographic resource is designed to facilitate a conversational partnership between health care practitioners and people with aphasia. It is also ideal for people with limited English language skills. It is based on the techniques of Supported Conversation for Adults with Aphasia™ (SCA™), developed by the Aphasia Institute ...
https://www.aphasia.ca/shop/preventing-and-managing-heart-disease/?add-to-cart=1025
Site map - Aphasia Toolbox
Aphasia Toolbox revolutionized the treatment & recovery of aphasia, Dysphasia Speech, and Stroke Aphasia recovery; helping hundreds of people recover since 1976.
https://www.aphasiatoolbox.com/sitemap
What To Expect When Your Wife With Aphasia Has A Stroke
Aphasia Toolbox revolutionized the treatment & recovery of aphasia, Dysphasia Speech, and Stroke Aphasia recovery; helping hundreds of people recover since 1976.
https://www.aphasiatoolbox.com/blog/41410-my-wife-just-had-a-stroke-and-has-aphasia-what-can-we-expect-what-should-we-do
Tips for Aphasia Help and Communication with People with Aphasia | iTAWC
iTAWC believes that family involvement and learning of communication strategies can provide aphasia support and aids in the recovery from aphasia.
https://itawc.com/communication-tips/
Speaking with Aphasia: Graduating my first graduate assistants!Speaking with Aphasia: Graduating my first graduate assistants!
A blog written by someone who is inspired daily by people with aphasia, who provides treatment for people with aphasia, who conducts research with people with aphasia and their close friends and family members, and who is constantly learning ...
http://speakingwithaphasia.blogspot.com/2014/05/graduating-my-first-graduate-assistants.html
Speaking with Aphasia: November 2016Speaking with Aphasia: November 2016
A blog written by someone who is inspired daily by people with aphasia, who provides treatment for people with aphasia, who conducts research with people with aphasia and their close friends and family members, and who is constantly learning ...
http://speakingwithaphasia.blogspot.com/2016/11/
ISRCTN - ISRCTN84429490: Can cognitive therapy reduce emotional burden in depressed carers of people with Alzheimers and...ISRCTN - ISRCTN84429490: Can cognitive therapy reduce emotional burden in depressed carers of people with Alzheimers and...
Participants are all family members providing substantial care for a relative with a primary progressive dementia such as Alzheimers disease or related conditions. The carers involved are all experiencing considerable difficulties with their own low mood or concern for the future to the extent that they could be classified as having a depressive disorder meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. ...
http://www.isrctn.com/ISRCTN84429490
Primary progressive aphasiaPrimary progressive aphasia
A third variant of primary progressive aphasia, logopenic progressive aphasia (LPA) was then added, and is an atypical form of ... "Primary Progressive Aphasia - National Aphasia Association". National Aphasia Association. Retrieved 2017-12-17. Mesulam M ( ... In the classical Mesulam criteria for primary progressive aphasia, there are two variants: a non-fluent type progressive ... M.-Marsel Mesulam coined the term primary progressive aphasia. Anomic aphasia Aphasiology Apraxia of speech Speech-language ...
https://en.wikipedia.org/wiki/Primary_progressive_aphasia
Progressive nonfluent aphasiaProgressive nonfluent aphasia
... which he called primary progressive aphasia (PPA) included patients with progressive nonfluent (aphasia, semantic dementia, and ... Bonner MF, Ash S, Grossman M (November 2010). "The new classification of primary progressive aphasia into semantic, logopenic, ... Mesulam MM (October 2003). "Primary progressive aphasia--a language-based dementia". The New England Journal of Medicine. 349 ( ... March 2004). "Cognition and anatomy in three variants of primary progressive aphasia". Annals of Neurology. 55 (3): 335-346. ...
https://en.wikipedia.org/wiki/Progressive_nonfluent_aphasia
Logopenic progressive aphasiaLogopenic progressive aphasia
... (LPA) is a variant of primary progressive aphasia. It is defined clinically by impairments in ... Aphasia Dementia Early-onset Alzheimer's disease Harciarek M, Kertesz A (September 2011). "Primary progressive aphasias and ... Compared to other subtypes of primary progressive aphasia, the logopenic variant has been found to be associated with cognitive ... Henry ML, Gorno-Tempini ML (December 2010). "The logopenic variant of primary progressive aphasia". Curr. Opin. Neurol. 23 (6 ...
https://en.wikipedia.org/wiki/Logopenic_progressive_aphasia
Expressive aphasiaExpressive aphasia
"Primary Progressive Aphasia - National Aphasia Association". National Aphasia Association. Retrieved 2018-11-26. "Common ... Expressive aphasia is classified as non-fluent aphasia, as opposed to fluent aphasia. Diagnosis is done on a case-by-case basis ... Expressive aphasia, also known as Broca's aphasia, is a type of aphasia characterized by partial loss of the ability to produce ... Expressive aphasia occurs in approximately 12% of new cases of aphasia caused by stroke. In most cases, expressive aphasia is ...
https://en.wikipedia.org/wiki/Expressive_aphasia
Anomic aphasiaAnomic aphasia
Conduction aphasia Expressive aphasia Lists of language disorders Primary progressive aphasia Receptive aphasia Tip of the ... Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of aphasia where ... Harciarek M, Kertesz A (September 2011). "Primary progressive aphasias and their contribution to the contemporary knowledge ... These results suggest minimal word-production difficulty in anomic aphasia relative to other aphasia syndromes. Anomic aphasia ...
https://en.wikipedia.org/wiki/Anomic_aphasia
AphasiaAphasia
... logopenic-variant primary progressive aphasia (lvPPA), and semantic-variant primary progressive aphasia (svPPA), with primary ... There are three classifications of Primary Progressive Aphasia : Progressive nonfluent aphasia (PNFA), Semantic Dementia (SD), ... and Logopenic progressive aphasia (LPA). Progressive Jargon Aphasia[citation needed] is a fluent or receptive aphasia in which ... Primary progressive aphasia (PPA) is a neurodegenerative focal dementia that can be associated with progressive illnesses or ...
https://en.wikipedia.org/wiki/Aphasia
Jargon aphasiaJargon aphasia
"Neologistic jargon aphasia and agraphia in primary progressive aphasia". Journal of the Neurological Sciences. 277 (1-2): 155- ... Jargon aphasia is a type of fluent aphasia in which an individual's speech is incomprehensible, but appears to make sense to ... 2010-01-05). "Prediction of pathology in primary progressive language and speech disorders". Neurology. 74 (1): 42-49. doi: ... All of these types of jargon are seen in fluent aphasia, which can more commonly be addressed as Wernicke's aphasia. Weinstein ...
https://en.wikipedia.org/wiki/Jargon_aphasia
Music therapy for non-fluent aphasiaMusic therapy for non-fluent aphasia
... primary progressive dynamic aphasia. Neurocase, 9(2), 140-155. doi:10.1076/neur.9.2.140.15068 Samson, S., & Zatorre, R. J. ( ... Non-fluent aphasia, also called expressive aphasia, is a neurological disorder that deprives patients of the ability to express ... As non-fluent aphasia is usually caused by lesions in patients' left hemisphere, the undamaged right hemisphere is regarded by ... Music therapy for non-fluent aphasia is a method for treating patients who have lost the ability to speak after a stroke or ...
https://en.wikipedia.org/wiki/Music_therapy_for_non-fluent_aphasia
Body part as objectBody part as object
Primary progressive aphasia (PPA) is a syndrome characterized by a progressive language deficit without other features of ... Weintraub, S., Rubin, N. P., & Mesulam, M. M. (1990). Primary progressive aphasia. Longitudinal course, neuropsychological ... Patterns of limb apraxia in primary progressive aphasia. Brain and Cognition, 53(2), 403-407. doi: https://dx.doi.org/10.1016/ ... It has been debated whether the existence of BPO errors can be used as a measure for aphasia or brain damage. In the studies ...
https://en.wikipedia.org/wiki/Body_part_as_object
Auditosensory cortexAuditosensory cortex
Primary progressive aphasia is characterised by the progressive impairment of speech production, comprehension and ... doi:10.1016/b978-0-12-666055-5.x5000-x. ISBN 978-0-12-666055-5. "Primary Progressive Aphasia". National Aphasia Association. ... primary progressive aphasia and auditory hallucination. The auditosensory cortex defines Brodmann area 42, which is part of the ... eventually causing primary progressive aphasia. Difficulty in auditory processing is a complication of mild traumatic brain ...
https://en.wikipedia.org/wiki/Auditosensory_cortex
Semantic dementiaSemantic dementia
... (SD), also known as semantic variant primary progressive aphasia (svPPA), is a progressive neurodegenerative ... Henry, M.L.; Gorno-Tempini, M.L. (December 2010). "The logopenic variant of primary progressive aphasia". Current Opinion in ... "Semantic variant Primary Progressive Aphasia". Association for Frontotemporal Degeneration. Retrieved 2017-12-18. Warrington, E ... Bonner, M.F.; Ash, S.; Grossman, M. (November 2010). "The new classification of primary progressive aphasia into semantic, ...
https://en.wikipedia.org/wiki/Semantic_dementia
AmnesiaAmnesia
"Semantic Variant Primary Progressive Aphasia". Memory and Aging Center. Retrieved 3 December 2019. "Amnesia: Management and ... Aphasia Betrayal Emotion and memory False memory Gollin figure test List of films featuring mental illness Memory erasure ... It is caused by brain damage due to a vitamin B1 deficiency and will be progressive if alcohol intake and nutrition pattern are ...
https://en.wikipedia.org/wiki/Amnesia
Maria Luisa Gorno-TempiniMaria Luisa Gorno-Tempini
... in particular primary progressive aphasia and frontotemporal dementia. Gorno-Tempini has had mentees from diverse backgrounds ( ... "Cognition and anatomy in three variants of primary progressive aphasia." Annals of neurology 55.3 (2004): 335-346.https://doi. ... "The logopenic/phonological variant of primary progressive aphasia." Neurology 71.16 (2008): 1227-1234. https://doi.org/10.1212/ ...
https://en.wikipedia.org/wiki/Maria_Luisa_Gorno-Tempini
VasectomyVasectomy
Rogalski E, Weintraub S, Mesulam MM (2013). "Are there susceptibility factors for primary progressive aphasia?". Brain Lang. ... An association between vasectomy and primary progressive aphasia, a rare variety of frontotemporal dementia, was reported. ... The primary long-term complications are chronic pain conditions or syndromes that can affect any of the scrotal, pelvic or ...
https://en.wikipedia.org/wiki/Vasectomy
Transcortical sensory aphasiaTranscortical sensory aphasia
Anomic aphasia Conduction aphasia Global aphasia Primary progressive aphasias Transcortical motor aphasia Broca's area ... TSA is a fluent aphasia similar to Wernicke's aphasia (receptive aphasia), with the exception of a strong ability to repeat ... receptive aphasia. However, transcortical sensory aphasia differs from receptive aphasia in that patients still have intact ... Transcortical sensory aphasia (TSA) is a kind of aphasia that involves damage to specific areas of the temporal lobe of the ...
https://en.wikipedia.org/wiki/Transcortical_sensory_aphasia
Thought disorderThought disorder
Rohrer JD, Rossor MN, Warren JD (February 2009). "Neologistic jargon aphasia and agraphia in primary progressive aphasia". ... Aphasia Auditory processing disorder Emil Kraepelin's dream speech Speech and language pathology Hart M, Lewine RR (May 2017 ... Noble J, Greene HL (15 January 1996). Textbook of primary care medicine. Mosby. p. 1325. ISBN 978-0-8016-7841-7. Jefferson JW, ... Kurowski, Kathleen; Blumstein, Sheila E. (February 2016). "Phonetic Basis of Phonemic Paraphasias in Aphasia: Evidence for ...
https://en.wikipedia.org/wiki/Thought_disorder
Alicinha CavalcantiAlicinha Cavalcanti
In 2015, Cavalcanti was diagnosed with primary progressive aphasia. In 2017, she was also diagnosed with amyotrophic lateral ... at the Albert Einstein Israelite Hospital in São Paulo on 2 August 2021 at age 59 as a result of primary progressive aphasia. ...
https://en.wikipedia.org/wiki/Alicinha_Cavalcanti
Insular cortexInsular cortex
March 2004). "Cognition and anatomy in three variants of primary progressive aphasia". Annals of Neurology. 55 (3): 335-46. doi ... Progressive expressive aphasia is the deterioration of normal language function that causes individuals to lose the ability to ... Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges JR (November 2003). "Progressive non-fluent aphasia is ... The anterior insula is part of the primary gustatory cortex. There is evidence that, in addition to its base functions, the ...
https://en.wikipedia.org/wiki/Insular_cortex
Woody DurhamWoody Durham
Durham was diagnosed with primary progressive aphasia in January 2016. In June 2016, Durham wrote a letter that was posted on ... Durham died on March 7, 2018, of complications from primary progressive aphasia. "Player Bio: Woody Durham". GoHeels.com. ... Deaths from primary progressive aphasia, People from Mebane, North Carolina, People from Albemarle, North Carolina). ...
https://en.wikipedia.org/wiki/Woody_Durham
ReadingReading
"Neural mechanisms of object naming and word comprehension in primary progressive aphasia". J. Neurosci. 32 (14): 4848-55. doi: ... Snowden JS, Kindell J, Thompson JC, Richardson AM, Neary D (March 2012). "Progressive aphasia presenting with deep dyslexia and ... Cherney LR (2004). "Aphasia, alexia, and oral reading". Top Stroke Rehabil. 11 (1): 22-36. doi:10.1310/VUPX-WDX7-J1EU-00TB. ... "Primary national strategy, UK" (PDF). 2006. "Home , Learn - Children's Literacy Initiative". learn.cli.org. Schwartz, Sarah ( ...
https://en.wikipedia.org/wiki/Reading
DementiaDementia
One type is called semantic variant primary progressive aphasia (SV-PPA). The main feature of this is the loss of the meaning ... The other type is called non-fluent agrammatic variant primary progressive aphasia (NFA-PPA). This is mainly a problem with ... a clinical analysis of the progressive aphasias". Brain. 131 (Pt 1): 8-38. doi:10.1093/brain/awm251. PMC 2373641. PMID 17947337 ... Given the progressive and terminal nature of dementia, palliative care can be helpful to patients and their caregivers by ...
https://en.wikipedia.org/wiki/Dementia
Language processing in the brainLanguage processing in the brain
Brambati SM, Ogar J, Neuhaus J, Miller BL, Gorno-Tempini ML (July 2009). "Reading disorders in primary progressive aphasia: a ... "The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia". Brain. 138 (Pt 8): 2423-37. ... Through research in aphasias, RHD signers were found to have a problem maintaining the spatial portion of their signs, ... See also the reviews by discussing this topic). The primary evidence for this role of the MTG-TP is that patients with damage ...
https://en.wikipedia.org/wiki/Language_processing_in_the_brain
Communication disorderCommunication disorder
Conduction aphasia Anomic aphasia Global aphasia Primary progressive aphasias Progressive nonfluent aphasia Semantic dementia ... and primary progressive aphasias caused by progressive illnesses such as dementia. Acute aphasias Expressive aphasia also known ... Receptive aphasia also known as Wernicke's aphasia, receptive aphasia is a fluent aphasia that is categorized by damage to the ... Harciarek M, Kertesz A (September 2011). "Primary progressive aphasias and their contribution to the contemporary knowledge ...
https://en.wikipedia.org/wiki/Communication_disorder
Dick EveyDick Evey
On May 23, 2013, Evey died from dementia and primary progressive aphasia. From 2007 until his death, Evey was a recipient of ...
https://en.wikipedia.org/wiki/Dick_Evey
Samuel BodmanSamuel Bodman
The cause of death was reported to be complications from primary progressive aphasia. His death was announced by former ... Deaths from primary progressive aphasia, Politicians from Chicago, United States Deputy Secretaries of Commerce, United States ...
https://en.wikipedia.org/wiki/Samuel_Bodman
Auditory agnosiaAuditory agnosia
"The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia". Brain. 138 (Pt 8): 2423-37. ... He attributed both aphasia and auditory agnosia to damage in Lichtheim's auditory word center. He hypothesized that aphasia is ... Marie P (1906). "What to think about subcortical aphasias (pure aphasias)". In Cole MR, Cole M (eds.). Pierre Marie's Papers on ... The primary distinction between auditory agnosia and cerebral deafness is the ability to detect pure tones, as measured with ...
https://en.wikipedia.org/wiki/Auditory_agnosia
Short-term memoryShort-term memory
Aphasias commonly occur after left-hemisphere stroke or with neurodegenerative conditions such as primary progressive aphasias ... which may also be a feature of logopenic primary progressive aphasia. Many language-impaired patients complain about short-term ... "Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease". Cortex. 71: 183- ... Short-term memory (or "primary" or "active memory") is the capacity for holding a small amount of information in an active, ...
https://en.wikipedia.org/wiki/Short-term_memory
Kimberly Williams-PaisleyKimberly Williams-Paisley
Her mother, Linda, was diagnosed with primary progressive aphasia, which is a form of dementia. Williams-Paisley is the author ...
https://en.wikipedia.org/wiki/Kimberly_Williams-Paisley
Deaths in September 2018Deaths in September 2018
Samuel Bodman, 79, American politician, Secretary of Energy (2005-2009), complications from primary progressive aphasia. Joris ...
https://en.wikipedia.org/wiki/Deaths_in_September_2018
Harold GuskinHarold Guskin
He had contracted primary progressive aphasia, a rare form of dementia, over decade before his death. LLC, New York Media (June ...
https://en.wikipedia.org/wiki/Harold_Guskin
Terry JonesTerry Jones
Deaths from primary progressive aphasia, Monty Python members, Deaths from dementia in England, People educated at Royal ... Jones was diagnosed with primary progressive aphasia, a form of frontotemporal dementia that impairs the ability to speak and ... Jones attended Esher COE primary school and the Royal Grammar School in Guildford, where he was school captain in the 1960-61 ... After living for several years with a degenerative aphasia, he gradually lost the ability to speak and died in 2020 from ...
https://en.wikipedia.org/wiki/Terry_Jones
Outline of the human brainOutline of the human brain
... primary somatosensory map within the somatosensory cortex), 2. output maps (primary motor map within the primary motor cortex ... Damage to this pathway can cause a form of aphasia known as conduction aphasia, where auditory comprehension and speech ... Neurodegeneration - an umbrella term for the progressive loss of structure or function of neurons, including death of neurons. ... As primary cancer treatments such as surgery, radiation therapy and chemotherapy have become more effective in the past few ...
https://en.wikipedia.org/wiki/Outline_of_the_human_brain
Deaths in October 2018Deaths in October 2018
... complications from primary progressive aphasia. Labinot Harbuzi, 32, Swedish footballer (Malmö FF, S.B.V. Excelsior, ...
https://en.wikipedia.org/wiki/Deaths_in_October_2018
Multiple sclerosis signs and symptomsMultiple sclerosis signs and symptoms
"Olfactory dysfunction in patients with primary progressive MS". Neurology - Neuroimmunology Neuroinflammation. 4 (4): e369. doi ... Navarro S, Mondéjar-Marín B, Pedrosa-Guerrero A, Pérez-Molina I, Garrido-Robres J, Alvarez-Tejerina A (2005). "[Aphasia and ... The authors found no evidence that pain was more common in people with progressive types of MS, in females compared to males, ... National clinical guideline for diagnosis and management in primary and secondary care. Salisbury, Wiltshire: Sarum ColourView ...
https://en.wikipedia.org/wiki/Multiple_sclerosis_signs_and_symptoms
David McFadden (poet)David McFadden (poet)
In 2012, McFadden was diagnosed with logopenic variant primary progressive aphasia, a type of Alzheimer's disease that affects ...
https://en.wikipedia.org/wiki/David_McFadden_(poet)
Early-onset Alzheimers diseaseEarly-onset Alzheimer's disease
... logopenic primary progressive aphasia. As the disease progresses, the patient exhibits more serious problems, becoming subject ... Levy-Lahad (1996) determined that PSEN2 contained 12 exons, 10 of which were coding exons, and that the primary transcript ...
https://en.wikipedia.org/wiki/Early-onset_Alzheimer's_disease
DysarthriaDysarthria
These allow people who are unintelligible, or may be in the later stages of a progressive illness, to continue to be able to ... It is unrelated to problems with understanding language (that is, dysphasia or aphasia), although a person can have both. Any ... Since regulation of skilled movements is a primary function of the cerebellum, damage to the superior cerebellum and the ...
https://en.wikipedia.org/wiki/Dysarthria
Deaths in March 2018Deaths in March 2018
... complications from primary progressive aphasia. Hao Bailin, 83, Chinese physicist. Victor Heringer, 29, Brazilian novelist, ...
https://en.wikipedia.org/wiki/Deaths_in_March_2018
Index of Singapore-related articlesIndex of Singapore-related articles
Ahmad Ibrahim Primary School Ahmad Ibrahim Secondary School Ahmad Latiff Khamaruddin Ahmad Mattar Ahmad Mohamed Ibrahim Ahmad ... Democratic Progressive Party (Singapore) Democratic Republic of the Congo at the 2010 Summer Youth Olympics Demographics of ... Neto Anucha Chuaysri Anugerah Planet Muzik Anumanthan Kumar Anurak Srikerd Anwar Hadi Anwell Technologies Apam balik Aphasia ( ... Primary School Leaving Examination Prime League Prime Minister of Singapore Prime Minister's Office (Singapore) Prime ...
https://en.wikipedia.org/wiki/Index_of_Singapore-related_articles
List of MeSH codes (C23)List of MeSH codes (C23)
... aphasia, conduction MeSH C23.888.592.604.150.500.800.100.155 - primary progressive aphasia MeSH C23.888.592.604.150.500.800.100 ... aphasia MeSH C23.888.592.604.150.500.800.100.100 - expressive aphasia MeSH C23.888.592.604.150.500.800.100.111 - ... chronic progressive external MeSH C23.888.592.636.447.690 - supranuclear palsy, progressive MeSH C23.888.592.636.637 - ... anomic aphasia MeSH C23.888.592.604.150.500.300 - dyslexia MeSH C23.888.592.604.150.500.300.200 - Alexia (acquired dyslexia) ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C23)
Cognitive disorderCognitive disorder
Unlike delirium, mild neurocognitive disorders tend to develop slowly and are characterized by a progressive memory loss which ... In addition to memory loss and cognitive impairment, other symptoms include aphasia, apraxia, agnosia, loss of abstract thought ... Setters, Belinda; Solberg, Laurence M. (2017). "Delirium". Primary Care: Clinics in Office Practice. Geriatrics. 44 (3): 541- ... they are not classified under neurocognitive disorders because loss of cognitive function is not the primary (causal) symptom. ...
https://en.wikipedia.org/wiki/Cognitive_disorder
List of neurological conditions and disordersList of neurological conditions and disorders
Primary lateral sclerosis Prion diseases Progressive hemifacial atrophy Progressive multifocal leukoencephalopathy Progressive ... aphasia) and syndromes (e.g., Aicardi syndrome). There is disagreement over the definitions and criteria used to delineate ... see Progressive supranuclear palsy Stiff-person syndrome Stroke Sturge-Weber syndrome Stuttering Subacute sclerosing ... disease Amaurosis fugax Amnesia Amyotrophic lateral sclerosis Acephalia Aneurysm Angelman syndrome Anosognosia Aphasia ...
https://en.wikipedia.org/wiki/List_of_neurological_conditions_and_disorders
Linguistic development of GenieLinguistic development of Genie
The primary focus of their research was to test the hypothesis of Eric Lenneberg that humans have a critical period for ... Even after learning the present progressive she inconsistently gave correct responses to it on tests, and use of the suffix - ... matching the timeline previously observed in children with various types of aphasia. Curtiss also noted that Genie used the ... When the circumstances of Genie, the primary victim in one of the most severe cases of abuse, neglect and social isolation on ...
https://en.wikipedia.org/wiki/Linguistic_development_of_Genie
Whitchurch-StouffvilleWhitchurch-Stouffville
Aphasia Centre, official website; "Stouffville's Aphasia Centre has Plenty to Celebrate", Stouffville Sun-Tribune, Oct. 17, ... The Progressive Montessori Academy, official website. Stouffville Christian School, official website. Mindtech (Montessori) ... Whitchurch-Stouffville is traversed by two railway lines: One is Canadian National Railway's primary freight corridor ... The York-Durham Aphasia Centre is located in Stouffville's Parkview Village, and is a program of March of Dimes Canada. The ...
https://en.wikipedia.org/wiki/Whitchurch-Stouffville
Letter boardLetter board
... primary progressive aphasia, supranuclear palsy, and traumatic brain injuries. AAC can be divided into different categories, ... Sign language is the primary example of unaided AAC. Aided forms of augmented communication require some external tools or aid ...
https://en.wikipedia.org/wiki/Letter_board
Network neuroscienceNetwork neuroscience
There are many types of aphasia but the main types fall into three categories: Broca aphasia, Wernicke aphasia, and Global ... Primary motor cortex and supplementary motor areas are also less active in patients with PD. The frontoparietal (FP) network in ... Alzheimer's disease (AD) is a progressive, neurodegenerative disease that can be clinically characterized by impaired memory ... Wernicke aphasia is when there is damage to the side portion of the language-dominant part of the brain. Wernicke's aphasia is ...
https://en.wikipedia.org/wiki/Network_neuroscience
Speech-language pathologySpeech-language pathology
In 2018, 193,971 children in English primary schools were on the special educational needs register needing speech-therapy ... Mental health issues Stroke Progressive neurological conditions such as cancer of the head, neck and throat (including ... "Speech and language therapy for aphasia following stroke". The Cochrane Database of Systematic Reviews. 2016 (6): CD000425. doi ... Primary pediatric speech and language disorders include: (i) receptive and (ii) expressive language disorders, (iii) speech ...
https://en.wikipedia.org/wiki/Speech–language_pathology
Genie (feral child)Genie (feral child)
They remained her primary caretakers throughout this time, but with the consent of her mother and psychologists, authorities ... In January 1972 the scientists measured her in the 50th percentile for an 81⁄2- to 9-year-old on Raven's Progressive Matrices, ... when a stroke left her with aphasia. She died in 1988 following another one. From January 1978 until the early 1990s, Genie ... When she moved in with them, Marilyn became her teacher, David decided to take over the role of her primary therapist James ...
https://en.wikipedia.org/wiki/Genie_(feral_child)
L1 (protein)L1 (protein)
... aphasia, spastic paraplegia and hydrocephalus). L1 protein is located all over the nervous system on the surface of neurons. It ... specifically the progressive myelination of nerve axon fibers), by mediating the elongation of Schwann cells along the axon. L1 ... a process that allows obtaining different mRNA mature molecules from one primary transcript of mRNA). L1CAM isoform 1 is known ... a comparison of the primary sequences of L1 molecules of different origin". Biochimica et Biophysica Acta (BBA) - Gene ...
https://en.wikipedia.org/wiki/L1_(protein)
Apraxia of speechApraxia of speech
... was not distinguished from other motor speech disorders such as dysarthria and in particular primary progressive aphasia. Many ... Recent research has established the existence of primary progressive apraxia of speech caused by neuroanatomic motor atrophy. ... AOS and expressive aphasia (also known as Broca's aphasia) are commonly mistaken as the same disorder mainly because they often ... May 2012). "Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech". Brain. 135 (Pt 5): 1522-36. ...
https://en.wikipedia.org/wiki/Apraxia_of_speech
Human brainHuman brain
The primary sensory areas receive signals from the sensory nerves and tracts by way of relay nuclei in the thalamus. Primary ... The papyrus mentions the external surface of the brain, the effects of injury (including seizures and aphasia), the meninges, ... Neurodegenerative diseases result in progressive damage to different parts of the brain's function, and worsen with age. Common ... The primary motor cortex, which sends axons down to motor neurons in the brainstem and spinal cord, occupies the rear portion ...
https://en.wikipedia.org/wiki/Human_brain
Cytochrome c oxidase subunit 2Cytochrome c oxidase subunit 2
A deletion mutation of a single nucleotide (7630delT) in the gene has been found to cause symptoms of reversible aphasia, right ... MT-CO2 provides the substrate-binding site and contains the binuclear copper A center, probably the primary acceptor in ... which altered the initiation codon of the MT-CO2 gene in patients have shown clinical manifestations such as progressive gait ... hemiparesis, hemianopsia, exercise intolerance, progressive mental impairment, and short stature. Furthermore, a patient with a ...
https://en.wikipedia.org/wiki/Cytochrome_c_oxidase_subunit_2

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