Anaphase
Anaphase-Promoting Complex-Cyclosome
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
Ubiquitin-Protein Ligase Complexes
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
Cdc20 Proteins
Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.
Cdh1 Proteins
Mitosis
Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
A highly evolutionarily conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc subunits 6, 7, and 8, have been shown to mediate protein-protein interactions, suggesting that Apc3 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to co-activators and APC-C inhibitors.
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
The largest subunit of the anaphase-promoting complex. It acts primarily as a scaffold for the proper organization and arrangement of subunits. The C-terminal region of Apc1 contains a series of tandem amino acid repeats that are also seen in the 26S proteasome regulatory particle, and may assist with forming and stabilizing protein-protein interactions.
Spindle Apparatus
Securin
Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Cyclin B
F-Box Proteins
A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
Genes, APC
Metaphase
Ligases
M Phase Cell Cycle Checkpoints
Cyclin A2
Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
Mad2 Proteins
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
Cyclin B1
Ubiquitin-Protein Ligases
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Prometaphase
CDC2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
HeLa Cells
Meiosis
Ubiquitination
Geminin
Schizosaccharomyces pombe Proteins
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
Cyclin A
Saccharomyces cerevisiae Proteins
Protein-Serine-Threonine Kinases
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Schizosaccharomyces
Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Separase
Amino Acid Sequence
Nocodazole
Mutation
Nuclear Proteins
Telophase
Aurora Kinases
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
Chromatids
Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Proto-Oncogene Proteins c-mos
Xenopus Proteins
G1 Phase
Genes, cdc
Protein Binding
Oocytes
Protein Subunits
Microtubules
Ubiquitin
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Ubiquitin-Conjugating Enzymes
Xenopus
Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc7, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc6 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
SKP Cullin F-Box Protein Ligases
Saccharomyces cerevisiae
Ubiquitins
Kinetochores
Proteasome Endopeptidase Complex
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Phosphorylation
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Chromosomes
Recombinant Fusion Proteins
S Phase
Amino Acid Motifs
Calcium-Binding Proteins
Drosophila Proteins
Models, Biological
G2 Phase
Protein Kinases
Substrate Specificity
Centromere
Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
Carrier Proteins
Repressor Proteins
Adenomatous Polyposis Coli Protein
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Cyclins
Drosophila
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Protein Stability
Chromosomal Proteins, Non-Histone
Macromolecular Substances
Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc7 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Cyclin-Dependent Kinases
Base Sequence
Microtubule-Associated Proteins
Sequence Homology, Amino Acid
Kinesin
A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.
Prophase
Bivalvia
Endoreduplication
Endopeptidases
Tubulin
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Interphase
Aurora Kinase B
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Spermatocytes
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Cell Division
Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
Centrosome
The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Microscopy, Fluorescence
Adenomatous Polyposis Coli
Binding Sites
Embryo, Nonmammalian
Saccharomycetales
Cloning, Molecular
Macropodidae
Two-Hybrid System Techniques
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
Chromosomes, Fungal
Caenorhabditis elegans
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Enzyme Activation
Cell Cycle Checkpoints
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Dyneins
Chromosomes, Human
Nondisjunction, Genetic
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Proteolysis
Multiprotein Complexes
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Gene Expression Regulation, Fungal
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Phosphoprotein Phosphatases
DNA-Binding Proteins
Green Fluorescent Proteins
Cell Nucleolus
Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I. (Singleton & Sainsbury, Dictionary of Microbiology & Molecular Biology, 2d ed)
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Proton-Translocating ATPases
Protein Phosphatase 2
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
Models, Molecular
DNA, Catenated
Phenotype
Potoroidae
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Protein Tyrosine Phosphatases
Chromosomal Instability
Protein C
Cytoskeletal Proteins
Dipodomys
Mutagenesis, Site-Directed
Aneuploidy
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Protein Transport
Sister Chromatid Exchange
An exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased by ultraviolet and ionizing radiation and other mutagenic agents and is particularly high in BLOOM SYNDROME.
Blotting, Western
Microscopy, Video
Diptera
An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).
Adenosine Triphosphatases
Mutagenesis
Luminescent Proteins
DNA Primers
Drosophila melanogaster
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Microinjections
Cytoplasm
Gene Deletion
Transfection
Peptide Fragments
Proto-Oncogene Proteins
Vaccines, Subunit
Nuclear Matrix-Associated Proteins
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
DNA, Complementary
Chromatin
Vacuolar Proton-Translocating ATPases
Salamandridae
Xenopus laevis
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Transcription, Genetic
Precipitin Tests
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (1/11)
We have identified two highly conserved RING finger proteins, ROC1 and ROC2, that are homologous to APC11, a subunit of the anaphase-promoting complex. ROC1 and ROC2 commonly interact with all cullins while APC11 specifically interacts with APC2, a cullin-related APC subunit. YeastROC1 encodes an essential gene whose reduced expression resulted in multiple, elongated buds and accumulation of Sic1p and Cln2p. ROC1 and APC11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1- and E2-dependent manner. ROC1 mutations completely abolished their ligase activity without noticeable changes in associated proteins. Ubiquitination of phosphorylated I kappa B alpha can be catalyzed by the ROC1 immunocomplex in vitro. Hence, combinations of ROC/APC11 and cullin proteins proteins potentially constitute a wide variety of ubiquitin ligases. (+info)Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. (2/11)
Homozygous inv mice lack a functional inversin protein and exhibit situs inversus plus severe cystic changes in the kidney and pancreas. Although the inversin sequence has provided few clues to its function, we and others have previously identified calmodulin as a binding partner. We now provide evidence that inversin interacts with the anaphase promoting complex protein Apc2. As expected of an Apc2 target, inversin possesses D-boxes and site-directed mutagenesis of the well-conserved D-box residues abrogates inversin-Apc2 interaction. An inversin-specific antibody reveals a dynamic expression pattern throughout the cell cycle and strong expression in the primary cilia of renal epithelium. Our data support a role for inversin in primary cilia and involvement in the cell cycle. Mutations of the proteins polaris, cystin and polycystin-2 which are expressed in renal epithelium primary cilia, lead to renal cystic changes. Aberrant cell proliferation is also involved in cyst development. The data reported here suggest that inversin may provide a link between these two mechanisms. (+info)Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. (3/11)
The anaphase-promoting complex or cyclosome (APC/C) is an ubiquitin protein ligase that together with Cdc20 and Cdh1 targets mitotic proteins for degradation by the proteosome. APC-Cdc20 activity during mitosis triggers anaphase by destroying securin and cyclins. APC-Cdh1 promotes degradation of cyclins and other proteins during G(1). We show that loss of APC/C during embryogenesis is early lethal before embryonic day E6.5 (E6.5). To investigate the role of APC/C in quiescent cells, we conditionally inactivated the subunit Apc2 in mice. Deletion of Apc2 in quiescent hepatocytes caused re-entry into the cell cycle and arrest in metaphase, resulting in liver failure. Re-entry into the cell cycle either occurred without any proliferative stimulus or could be easily induced. We demonstrate that the APC has an additional function to prevent hepatocytes from unscheduled re-entry into the cell cycle. (+info)Depletion of anaphase-promoting complex or cyclosome (APC/C) subunit homolog APC1 or CDC27 of Trypanosoma brucei arrests the procyclic form in metaphase but the bloodstream form in anaphase. (4/11)
The anaphase-promoting complex or cyclosome (APC/C) is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. It triggers elimination of key cell cycle regulators such as securin and mitotic cyclins during mitosis by polyubiquitinating them for proteasome degradation. Seven core subunit homologs of APC/C (APC1, APC2, APC11, CDC16, CDC23, CDC27, and DOC1) were identified in the Trypanosoma brucei genome data base. Expression of six of them was individually ablated by RNA interference in both the procyclic and bloodstream forms of T. brucei. Only the CDC27- and APC1-depleted cells were enriched in the G2/M phase with inhibited growth. Further studies indicated that T. brucei APC1 and CDC27 failed to complement the corresponding deletion mutants of budding yeast. However, their depletion from procyclic-form T. brucei enriched cells with two kinetoplasts and an enlarged nucleus possessing short metaphase-like mitotic spindles, suggesting that APC1 and CDC27 may play essential roles in promoting anaphase in the procyclic form. Their depletion from the bloodstream form, however, enriched cells with two kinetoplasts and two nuclei connected through a microtubule bundle, suggesting a late anaphase arrest. This is the first time functional APC/C subunit homologs were identified in T. brucei. The apparent differential activities of this putative APC/C in two distinct developmental stages suggest an unusual function. The apparent lack of functional involvement of some of the other individual structural subunit homologs of APC/C may indicate the structural uniqueness of T. brucei APC/C. (+info)An architectural map of the anaphase-promoting complex. (5/11)
The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 core subunits and either of two loosely associated regulatory subunits, Cdc20 and Cdh1. We analyzed the architecture of the APC using a recently constructed budding yeast strain that is viable in the absence of normally essential APC subunits. We found that the largest subunit, Apc1, serves as a scaffold that associates independently with two separable subcomplexes, one that contains Apc2 (Cullin), Apc11 (RING), and Doc1/Apc10, and another that contains the three TPR subunits (Cdc27, Cdc16, and Cdc23). We found that the three TPR subunits display a sequential binding dependency, with Cdc27 the most peripheral, Cdc23 the most internal, and Cdc16 between. Apc4, Apc5, Cdc23, and Apc1 associate interdependently, such that loss of any one subunit greatly reduces binding between the remaining three. Intriguingly, the cullin and TPR subunits both contribute to the binding of Cdh1 to the APC. Enzymatic assays performed with APC purified from strains lacking each of the essential subunits revealed that only cdc27Delta complexes retain detectable activity in the presence of Cdh1. This residual activity depends on the C-box domain of Cdh1, but not on the C-terminal IR domain, suggesting that the C-box mediates a productive interaction with an APC subunit other than Cdc27. We have also found that the IR domain of Cdc20 is dispensable for viability, suggesting that Cdc20 can activate the APC through another domain. We have provided an updated model for the subunit architecture of the APC. (+info)Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. (6/11)
(+info)Regulation of ciliary polarity by the APC/C. (7/11)
(+info)Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. (8/11)
(+info)
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ANAPC2
2004). "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit". ... A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition ... 2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): ... Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. ...
Anaphase-promoting complex
The APC/C is a large complex of 11-13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other ... April 2015). "Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome". Journal ... Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins ... The catalytic core of the APC/C consists of the cullin subunit Apc2 and RING H2 domain subunit Apc11. These two subunits ...
Cullin
... or APC2), part of the Anaphase-promoting complex. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin ... and the ANAPC2 subunit of the anaphase-promoting complex/cyclosome; both CUL9 and ANAPC2 have ubiquitin ligase activity. The N- ... The human genome contains eight cullin genes CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) ... CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member called ANAPC2 ...
DeCS
Apc2 Subunit, Anaphase Promoting Complex Apc2 Subunit, Anaphase Promoting Complex Cyclosome Apc2 Subunit, Anaphase-Promoting ... Apc2 Subunit, Anaphase Promoting Complex. Apc2 Subunit, Anaphase Promoting Complex Cyclosome. Apc2 Subunit, Anaphase-Promoting ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092.750] Apc2 Subunit, Anaphase-Promoting Complex- ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092.500] Apc1 Subunit, Anaphase-Promoting Complex- ...
Pesquisa | Prevenção e Controle de Câncer
Here, we show that the anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase for Mdm2 degradation. We ... demonstrate that APC2, a scaffold subunit of APC/C, binds to Mdm2 and is required for Mdm2 polyubiquitination and proteasomal ... The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2. ... Mechanistically, UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, ...
Structural basis for the subunit assembly of the anaphase-promoting complex. - Oxford Cardiovascular Science
Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-phosphorylation sites, relative to co-activator, regulatory proteins and ... Our structure explains how this TPR sub-complex, together with additional scaffolding subunits (Apc1, Apc4 and Apc5), ... Here, we describe a recombinant expression system that allows the reconstitution of holo APC/C and its sub-complexes that, when ... Three conserved tetratricopeptide repeat (TPR) subunits (Cdc16, Cdc23 and Cdc27) share related superhelical homo-dimeric ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary...
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome Actions. * Search in PubMed * Search in MeSH ... We now provide evidence that inversin interacts with the anaphase promoting complex protein Apc2. As expected of an Apc2 target ... APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Tang ... Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary ...
MeSH Browser
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.750] * Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092.750] * Apc3 Subunit, Anaphase-Promoting Complex- ... Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.937] * Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.984] * Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome [ ...
MeSH Browser
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.750] * Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092.750] * Apc3 Subunit, Anaphase-Promoting Complex- ... Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.937] * Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.984] * Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome [ ...
6167 CullinThalassiosira pseudonana | Diatom Portal
NDF-RT Code NDF-RT Name
Anaphase-Promoting Complex-Cyclosome N0000189459 Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome N0000189465 Apc2 Subunit, ... Anaphase-Promoting Complex-Cyclosome N0000189462 Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome N0000189466 Apc4 Subunit, ... Anaphase-Promoting Complex-Cyclosome N0000189467 Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome N0000189464 Apc6 Subunit, ... Anaphase-Promoting Complex-Cyclosome N0000189457 Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome N0000189455 Apc8 Subunit, ...
NEW (2014) MESH HEADINGS WITH SCOPE NOTES (UNIT RECORD FORMAT; 7/29/2013
HN - 2014 MH - Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome UI - D064190 MN - D8.811.464.938.750.92.750 MN - D12.776. ... Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It ... HN - 2014 MH - Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome UI - D064197 MN - D8.811.464.938.750.92.625 MN - D12.776. ... HN - 2014 MH - Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome UI - D064198 MN - D8.811.464.938.750.92.687 MN - D12.776. ...
DeCS 2014 - New terms
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc1 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc1 ... Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidade Apc3 do Ciclossomo-Complexo Promotor de Anáfase. Subunidad Apc3 ...
Sumoylation promotes optimal apc/c activation and timely anaphase<...
"Sumoylation promotes optimal apc/c activation and timely anaphase",. abstract = "The Anaphase Promoting Complex/Cyclosome (APC/ ... that sumoylation of the APC4 subunit of the APC/C peaks during mitosis and is critical for timely APC/C activation and anaphase ... We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the ... The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC ...
Biomarkers Search
2. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.. Yamaguchi M; Yu S; ... 4. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.. Vodermaier HC; Gieffers C; ... 7. The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.. Rahimi H; Ahmadzadeh A; Yousef-amoli ... Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis.. Zhang J; ...
Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex...
... the anaphase-promoting complex/cyclosome (APC/C), in regulating the basal localisation of Miranda. The APC/C is a multi-subunit ... Loss-of-function mutants for APC/C subunits cdc27(F) and morula (mr, APC2; G) also show Miranda pericentrosomal accumulation. ( ... In this study we report a novel role for the anaphase-promoting complex/cyclosome (APC/C) during this process. Attenuation of ... The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. ...
strainid orf gene zyg qualifier SGTC 2782|7736369.score SGTC 2782|7736369.expt.zyg.pval SGTC 2782|7736369.expt.zyg.significant...
CHROMOSOME UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ... epsilon DNA polymerase complex,cytoplasm YLR127C YLR127C APC2 het Verified 1.27225955785246 0.101640456359275 no 144 ... CYTOSKELETON UBIQUITIN LIGASE COMPLEX Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ... PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin- ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
DeCS 2014 - Novos termos
Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase. Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc2 ... Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc1 del Ciclosoma-Complejo Promotor de la Anafase. ... Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome. Subunidad Apc10 del Ciclosoma-Complejo Promotor de la Anafase. ...
MeSH Browser
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.750] * Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092.687] * Apc2 Subunit, Anaphase-Promoting Complex- ... Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.937] * Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome [ ... Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome [D12.776.167.024.984] * Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome [ ...
Dissection of the APCCdh1-Skp2 Cascade in Breast Cancer | Clinical Cancer Research | American Association for Cancer Research
Stewart S, Fang G. Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol ... Expression of APC2, a key subunit of the APC, showed similar levels between normal and breast cancer tissue. The accumulation ... Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant ... Liu W, Wu G, Li W, Lobur D, Wan Y. Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor β ...
"sequence id","alias","species","description",...
"Cell cycle.mitosis and meiosis.metaphase to anaphase transition.Anaphase-Promoting Complex/Cyclosome (APC/C)-dependent ... "anaphase-promoting complex subunit 8","protein_coding" "AT3G48185","No alias","Arabidopsis thaliana","unknown protein; Has 4 ... ubiquitination.APC/C E3 ubiquitin ligase complex.catalytic core subcomplex.APC2 component","protein_coding" "Cre10.g460600","No ... "Cell cycle.mitosis and meiosis.metaphase to anaphase transition.Anaphase-Promoting Complex/Cyclosome (APC/C)-dependent ...
and
... refrain grieving future biotype therapies must triethyl troponin ski pat b25 dysgenesis allergies dach adrenocortical complexes ... wood agency scoliosis staging methacrylate choline how cauterization nor persistent instrument mix neisseria promote bilirubin ... side acetic etoposide film fractures segmental tartrate doppler supply longitudinal channel chloroethyl gluconate subunit ... sweets phytanic bufotenine apexification malaysia tol rtx underarm cardioselective alkane partridge optometrist lubrol anaphase ...