Loeys-Dietz Syndrome: An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Bioprosthesis: Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Heart Valve Prosthesis: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.Sinus of Valsalva: The dilatation of the aortic wall behind each of the cusps of the aortic valve.Tricuspid Valve Insufficiency: Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Balloon Valvuloplasty: Widening of a stenosed HEART VALVE by the insertion of a balloon CATHETER into the valve and inflation of the balloon.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mitral Valve Stenosis: Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Tricuspid Valve: The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.Pulmonary Valve Insufficiency: Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.Venous Valves: Flaps within the VEINS that allow the blood to flow only in one direction. They are usually in the medium size veins that carry blood to the heart against gravity.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Pulmonary Valve Stenosis: The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.Calcinosis: Pathologic deposition of calcium salts in tissues.

Investigation of the theory and mechanism of the origin of the second heart sound. (1/2271)

To investigate further the origin of the second heart sound we studied human subjects, dogs, and a model in vitro of the cardiovascular system. Intra-arterial sound, pressure, and, where possible, flow and high speed cine (2,000 frames/sec) were utilized. The closure sound of the semilunar valves was of higher amplitude in be ventricles than in their respective arterial cavities. The direction of inscription of the main components of intra-arterial sound were opposite in direction to the components of intraventricular sound. Notches, representative of pressure increments, were noted on the ventricular pressure tracings and were coincident with the components of sound. The amplitude of the closure sound varied with diastolic pressure, but remained unchanged with augmentation of forward and retrograde aortic flow. Cines showed second sound to begin after complete valvular closure, and average leaflet closure rate was constant regardless of pressure. Hence, the semilunar valves, when closed, act as an elastic membrane and, when set into motion, generate compression and expansion of the blood, producing transient pressure changes indicative of sound. The magnitude of the initial stretch is related to the differential pressure between the arterial and ventricular chambers. Sound transients which follow the major components of the second sound appear to be caused by the continuing stretch and recoil of the leaflets. Clinically unexplained findings such as the reduced or absent second sound in calcific aortic stenosis and its paradoxical presence in congenital aortic stenosis may be explained by those observations.  (+info)

Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve. (2/2271)

1. Using a microelectrode technique, acetylcholine (ACh)-induced membrane potential changes were characterized using various types of inhibitors of K+ and Cl- channels in rabbit aortic valve endothelial cells (RAVEC). 2. ACh produced transient then sustained membrane hyperpolarizations. Withdrawal of ACh evoked a transient depolarization. 3. High K+ blocked and low K+ potentiated the two ACh-induced hyperpolarizations. Charybdotoxin (ChTX) attenuated the ACh-induced transient and sustained hyperpolarizations; apamin inhibited only the sustained hyperpolarization. In the combined presence of ChTX and apamin, ACh produced a depolarization. 4. In Ca2+-free solution or in the presence of Co2+ or Ni2+, ACh produced a transient hyperpolarization followed by a depolarization. In BAPTA-AM-treated cells, ACh produced only a depolarization. 5. A low concentration of A23187 attenuated the ACh-induced transient, but not the sustained, hyperpolarization. In the presence of cyclopiazonic acid, the hyperpolarization induced by ACh was maintained after ACh removal; this maintained hyperpolarization was blocked by Co2+. 6. Both NPPB and hypertonic solution inhibited the membrane depolarization seen after ACh washout. Bumetanide also attenuated this depolarization. 7. It is concluded that in RAVEC, ACh produces a two-component hyperpolarization followed by a depolarization. It is suggested that ACh-induced Ca2+ release from the storage sites causes a transient hyperpolarization due to activation of ChTX-sensitive K+ channels and that ACh-activated Ca2+ influx causes a sustained hyperpolarization by activating both ChTX- and apamin-sensitive K+ channels. Both volume-sensitive Cl- channels and the Na+-K+-Cl- cotransporter probably contribute to the ACh-induced depolarization.  (+info)

Extent and severity of atherosclerotic involvement of the aortic valve and root in familial hypercholesterolaemia. (3/2271)

OBJECTIVE: To compare the frequency of valvar and supravalvar aortic stenosis in homozygous and heterozygous familial hypercholesterolaemia (FH). DESIGN: Analysis of life time cholesterol exposure and prevalence of aortic atherosclerosis in 84 consecutive cases attending a lipid clinic. SETTING: A tertiary referral centre in London. PATIENTS: Outpatients with FH (six homozygous, 78 heterozygous). INTERVENTIONS: Maintenance of lipid lowering treatment. MAIN OUTCOME MEASURES: Calculated cholesterol x years score (CYS) and echocardiographic measurement of aortic root diameter, aortic valve thickness, and transaortic gradient. RESULTS: Four homozygotes with a mean (SD) CYS of 387 (124) mmol/1 x years had severe aortic stenosis (treatment started after seven years of age), whereas the other two had echocardiographic evidence of supravalvar thickening but no aortic valve stenosis (treatment started before three years of age). On multivariate analysis, mean transaortic gradient correlated significantly with CYS (mean = 523 (175) mmol/1 x years) in heterozygotes (p = 0.0001), but only two had severe aortic valve and root involvement. CONCLUSIONS: In patients with familial hypercholesterolaemia, aortic stenosis is common in homozygotes, and aortic root involvement is always present despite the lower CYS than in heterozygotes. It appears to be determined by short term exposure to high cholesterol concentrations in early life. Conversely, aortic root and valve involvement are rare in heterozygotes and occur only with severe, prolonged hypercholesterolaemia, possibly accelerating age related degenerative effects.  (+info)

Bileaflet mechanical prostheses for aortic valve replacement in patients younger than 65 years and 65 years of age or older: major thromboembolic and hemorrhagic complications. (4/2271)

OBJECTIVE: To determine major thromboembolic and hemorrhagic complications and predictive risk factors associated with aortic valve replacement (AVR), using bileaflet mechanical prostheses (CarboMedics and St. Jude Medical). DESIGN: A case series. SETTING: Cardiac surgical services at the teaching institutions of the University of British Columbia. PATIENTS AND METHODS: Patients 2 age groups who had undergone AVR between 1989 and 1994 were studied. Group 1 comprised 384 patients younger than 65 years. Group 2 comprised 215 patients 65 years of age and older. RESULTS: The linearized rates of major thromboembolism (TE) occurring after AVR were 1.54%/patient-year for group 1 and 3.32%/patient-year for group 2; the rates for major TE occurring more than 30 days after AVR were 1.13%/patient-year for group 1 and 1.55%/patient-year for group 2. The crude rates for major TE occurring within 30 days of AVR were 1.04% for group 1 and 3.72% for group 2. The death rate from major TE in group 1 was 0.31%/patient-year and in group 2 was 0.88%/patient-year. Of the major TE events occurring within 30 days, 100% of patients in both age groups were inadequately anticoagulated at the time of the event, and for events occurring more than 30 days after AVR, 45% in group 1 and 57% in group 2 were inadequately anticoagulated (INR less than 2.0). The overall linearized rates of major hemorrhage were 1.54%/patient-year for group 1 and 2.21%/patient-year for group 2. There were no cases of prosthesis thrombosis in either group. The mean (and standard error) overall freedom from major TE for group 1 patients at 5 years was 95.6% (1.4%) and with exclusion of early events was 96.7% (1.3%); for group 2 patients the rates were 90.0% (3.2%) and 93.7% (3.0%), respectively. The mean (and SE) overall freedom from major and fatal TE and hemorrhage for group 1 patients was 90.1% (2.3%) and with exclusion of early events was 91.2% (2.3%); for group 2 patients the rates were 87.9% (3.1%) and 92.5% (2.9%), respectively. The 5-year rate for freedom from valve-related death for group 1 patients was 96.3% (2.1%) and for group 2 patients was 97.2% (1.2%). CONCLUSION: The thromboembolic and hemorrhagic complications after AVR with bileaflet mechanical prostheses occur more frequently and result in more deaths in patients 65 years of age and older than in patients years younger than 65 years.  (+info)

Minimally invasive aortic valve replacement through a transverse sternotomy: a word of caution. (5/2271)

OBJECTIVES: To compare aortic valve replacement (AVR) using a minimally invasive approach through a transverse sternotomy with the established approach of median sternotomy. DESIGN: Retrospective, case-control study. PATIENTS: Fourteen high risk patients (median age 78, Parsonnet score of 18%) who underwent AVR performed through a minimally invasive transverse sternotomy were compared with a historical group of patients matched for age, sex, and Parsonnet score who underwent AVR performed through a median sternotomy by the same surgeon. OUTCOME MEASURES: Cross clamp time, total bypass time, intensive care stay, postoperative in-hospital stay, morbidity, and mortality. RESULTS: There were two deaths in the minimally invasive group and none in the control group (NS). The cross clamp and total bypass times were longer in the minimally invasive group (67 and 92 minutes v 46 and 66 minutes, p < 0.001). There was a higher incidence of re-exploration for bleeding (14% v 0%) and paravalvar leaks (21% v 0%) in the minimally invasive group but these differences were not significant. The minimally invasive group had a longer postoperative in-hospital stay (p = 0.025). The incidence of mortality or major morbidity was 43% (six of 14) in the minimally invasive group and 7% (one of 14) in the matched pairs (p = 0.013). CONCLUSIONS: AVR can be performed through a transverse sternotomy but the operation takes longer and there is an unacceptably high incidence of morbidity and mortality.  (+info)

Role of glutaraldehyde in calcification of porcine aortic valve fibroblasts. (6/2271)

Glutaraldehyde-treated porcine aortic valve xenografts frequently fail due to calcification. Calcification in the prostheses begins intracellularly. In a previous study, various types of cell injury to canine valvular fibroblasts, including glutaraldehyde treatment, led to calcification. An influx of extracellular Ca2+ into the phosphate-rich cytosol was theorized to be the mechanism of calcification. To test the Ca2+ influx theory, cytosolic Ca2+ and Pi concentrations were assessed in glutaraldehyde-treated porcine aortic valve fibroblasts, and their relationship to a subsequent calcification was studied. Glutaraldehyde caused an immediate and sustained massive cytosolic Ca2+ increase that was dose dependent and a several-fold increase in Pi. Calcification of cells followed within a week. The earliest calcification was observed in blebs formed on glutaraldehyde-treated cells. Live control cells or cells fixed with glutaraldehyde in Ca2+-free solution did not calcify under the same conditions. Concomitant increases in Ca2+ and Pi in glutaraldehyde-treated cells appear to underlie the mechanism of calcification, and the presence of extracellular Ca2+ during glutaraldehyde fixation promotes calcification.  (+info)

Perivalvular abscesses associated with endocarditis; clinical features and prognostic factors of overall survival in a series of 233 cases. Perivalvular Abscesses French Multicentre Study. (7/2271)

AIMS: The purposes of this study were to determine the clinical features and to identify prognostic factors of abscesses associated with infective endocarditis. METHODS AND RESULTS: During a 5-year period from January 1989, 233 patients with perivalvular abscesses associated with infective endocarditis were enrolled in a retrospective multicentre study. Of the patients, 213 received medical surgical therapy and 20 medical therapy alone. No causative microorganism could be identified in 31% of cases. Sensitivity for the detection of abscesses was 36 and 80%, respectively using transthoracic and transoesophageal echocardiography. Surgical treatment consisted of primary suture of the abscess (38%), insertion of a felt aortic or mitral ring using Teflon or pericardium (42%), or debridment of the abscess cavity (20%). The 1 month operative mortality was 16%. Actuarial rates for overall survival at 3 and 27 months in operated patients were 75 +/- 10% and 59 +/- 11%, respectively. Increasing patient age, staphylococcal infection, and fistulization of the abscess were found to be independent risk factors in both 1 month and overall operative mortality. Renal failure was a risk factor predictive of operative mortality at 1 month, whereas uncontrolled infection and circumferential abscess were regarded as risk factors predictive of overall operative mortality. CONCLUSION: The data determined prognostic factors of abscesses associated with infective endocarditis.  (+info)

Syphilitic aortic regurgitation. An appraisal of surgical treatment. (8/2271)

During the 10 years from 1964 to 1973, fifteen patients with severe syphilitic aortic regurgitation were treated surgically at the National Heart Hospital. In thirteen the valve was replaced and in two it was repaired. In addition four had replacement of an aneurysmal ascending aorta with a Dacron graft and seven some form of plastic repair to the coronary ostia. Three patients died within 1 month of surgery and a further six during the follow-up period which varied from 1 to 55 months (mean 25-5). The six survivors have been followed-up for an average of 33 months. Factors contributing to this high mortality were analysed and it was found that the mean duration of effort dyspnoea was 22 months in the survivors compared with 48 months in those who had died. Similarly the average duration of nocturnal dyspnoea was 4 months in the survivors compared with a mean of 8 months in those who had died. Only six out of the fifteen patients had angina; this was present in two of the survivors and in four of the fatalities. The pulse pressure, heart size, and haemodynamic findings were similar in the two groups. The prognostic value of an elevated erythocyte sedimentation rate was also examined. It was concluded that preoperative investigations should include aortography, coronary arteriography, an assessment of left ventricular function, and whenever possible myocardial biopsy. These data were interpreted as suggesting that patients should be referred for surgery at an earlier stage in the disease--certainly before the onset of cardiac failure and--and that if this more aggresive attitude was adopted, as it has been in non-syphilitic cases of aortic valve disease, the present high mortality in this group would be reduced.  (+info)

*Aortic valve

... replacement is a surgical procedure in which a patient's aortic valve is replaced by a different valve. The aortic ... The Aortic Valve and Aortic Sinuses" Aortic Valve, Bicuspid at eMedicine Hans-Joachim Schäfers: Current treatment of aortic ... can often have a bicuspid aortic valve as one of its symptoms. Aortic valve repair or aortic valve reconstruction describes the ... the aortic pressure forces the aortic valve to close. The closure of the aortic valve contributes the A2 component of the ...

*Aortic valve replacement

... Information for Patients Information on Aortic Valve Replacement Animation of Aortic Valve Replacement ... Aortic valve replacement is a procedure in which a patient's failing aortic valve is replaced with an artificial heart valve. ... the valve can either become leaky (aortic insufficiency) or partially blocked (aortic stenosis). Current aortic valve ... aortic valve replacement became accepted therapy for patients with severe aortic insufficiency or regurgitation. Aortic valve ...

*Aortic valve repair

... of the aortic valve. Thus, congenital aortic stenosis may be treated by aortic valve repair. In acquired aortic stenosis valve ... In most instances aortic valve repair will be performed for aortic regurgitation (insufficiency). Aortic valve repair may also ... aortic valve. The colleagues of Dwight Harken reported in 1958 on their experience with aortic valve repair for aortic ... is created for the aortic valve. Thus, a bicuspid valve is created which results in near-normal function of the aortic valve. ...

*Quadricuspid aortic valve

... and aortic valve replacement, usually with a synthetic valve. Quadricuspid aortic valves are very rare cardiac valvular ... A short-axis ultrasound of the aortic valve allows for the best view of the aortic valve, and gives a clear indication of the ... Zhu, J., Zhang, J., Wu, S., Zhang, Y., Ding, F., & Mei, J. (2013). Congenital quadricuspid aortic valve associated with aortic ... Tutarel, O. (2004). The quadricuspid aortic valve: a comprehensive review. The Journal of Heart Valve Disease, 13(4), 534-537. ...

*Bicuspid aortic valve

... (BAV) is an inherited form of heart disease in which two of the leaflets of the aortic valve fuse during ... July 2013). "Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve ... Notable complications of BAV include narrowing of the aortic valve opening, backward blood flow at the aortic valve, dilation ... Most patients with bicuspid aortic valve whose valve becomes dysfunctional will need careful follow-up and potentially valve ...

*Aortic valve area calculation

... is an indirect method of determining the area of the aortic valve (aortic valve area or AVA). The ... Aortic Valve Area (cm 2 ) = LVOT diameter 2 ⋅ 0.78540 ⋅ LVOT VTI Aortic Valve VTI {\displaystyle {\text{Aortic Valve Area (cm ... The Gorlin equation states that the aortic valve area is equal to the flow through the aortic valve during ventricular systole ... Aortic Valve area (cm 2 ) ≈ Cardiac Output ( litre min ) Peak to Peak Gradient (mmHg) {\displaystyle {\text{Aortic Valve area ( ...

*Percutaneous aortic valve replacement

The valve delivery system is inserted in the body, the valve is positioned and then implanted inside the diseased aortic valve ... Percutaneous aortic valve replacement (PAVR), also known as transcatheter aortic valve implantation (TAVI) or transcatheter ... Until recently, surgical aortic valve replacement was the standard of care in adults with severe symptomatic aortic stenosis. ... "Transcatheter Aortic Valve Replacement Devices". Retrieved December 2013. Agarwal S, et al. (Feb 2015). "Transcatheter aortic ...

*Valve-sparing aortic root replacement

Aortic aneurysm Aortic dissection Marfan syndrome Chapter 31: Aortic Valve Repair and Aortic Valve-Sparing Operations by Tirone ... It involves replacement of the aortic root without replacement of the aortic valve. Two similar procedures were developed, one ... David T, Feindel C (1992). "An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ... Valve-sparing aortic root replacement (also known as the David procedure) is a cardiac surgery procedure which is used to treat ...

*Nonbacterial thrombotic endocarditis

... mitral valve > aortic valve > tricuspid valve > pulmonary valve Grossly, vegetations form along lines of valve closure and are ... is a form of endocarditis in which small sterile vegetations are deposited on the valve leaflets. Formerly known as marantic ... The disease affects the valves with the following predilection: ...

*Russell M. Nelson

In an indication of his surgical skill, a 1968 case series of his aortic valve replacements demonstrated an exceptionally low ... Later, he performed the same operation on future LDS Church president Spencer W. Kimball, replacing his damaged aortic valve. ... Nelson, RM; Jenson, CB; Jones, KW (October 1968). "Aortic valve replacement". The Annals of thoracic surgery. 6 (4): 343-50. ... In 1960, he performed one of the first-ever repairs of tricuspid valve regurgitation. His patient was a Latter-day Saint stake ...

*List of OMIM disorder codes

SLC6A4 Aortic aneurysm, familial thoracic 4; 132900; MYH11 Aortic aneurysm, familial thoracic 6; 611788; ACTA2 Aortic valve ... MAPT Supravalvar aortic stenosis; 185500; ELN Surfactant metabolism dysfunction, pulmonary, 1; 265120; SFTPB Surfactant ...

*Secondary hypertension

Aortic valve disease: unclear cause. Aortic valve disease most often results from longstanding hypertension according to ...

*Vilém Dušan Lambl

... especially in the Aortic Valve. Lambl's excrescences: Small fibrin deposits on the aortic valve. Vilem Dusan Lambl @ Who Named ...

*GSIS-Meralco bribery case

... and aortic valve stenosis (AS)." Reyes's physician, Dr. Francisco Lukban, however, later declared him stable. Associate Justice ...

*Jordin Kare

Jordin's aortic valve is failing. He is having surgery June 28 to replace..., by Mary Kay Kare, on Twitter; published June 21, ... In June 2017, Kare's wife Mary Kay announced via Twitter that his aortic valve was failing and needed to be replaced. On July ...

*ADINA

"Simulation of Aortic Valve Tech Brief". ADINA R & D, Official Webpage. "ADINA Multiphysics, Official Webpage". "ADINA CAD/CAE ...

*Donald S. Miller

Garcia, D (2000). "Assessment of Aortic Valve Stenosis Severity". Circulation. 101: 765-771. doi:10.1161/01.cir.101.7.765. ...

*Donald Ross (surgeon)

He has said that his interest had lain "particularly with the valves-especially the aortic valve-but, in general, anything that ... it involves replacing a patient's damaged aortic valve with his or her own pulmonary valve. Ross believed that, "with care, the ... Ross D.N. (1967). "Replacement of aortic and mitral valves with a pulmonary autograft". Lancet. 2: 956. doi:10.1016/s0140-6736( ... In 1962 Ross introduced the use of homografts to replace diseased aortic valves. He used a technique of subcoronary ...

*Winged scapula

August 2009). "Winged scapula after aortic valve replacement". Ann Thorac Surg. 1 (87): 1277-1279. doi:10.1016/j.athoracsur. ...

*Papillary fibroelastoma

In the case of aortic valve involvement, excision of the tumor is often valve-sparing, meaning that replacement of the valve ... Takada A, Saito K, Ro A, Tokudome S, Murai T (2000). "Papillary fibroelastoma of the aortic valve: a sudden death case of ... Westhof FB, Chryssagis K, Liangos A, Batz G, Diegeler A (2007). "Aortic valve leaflet reconstruction after excision of a ... Kumbala D, Sharp T, Kamalesh M (2008). ""Perilous pearl"--papillary fibroelastoma of aortic valve: a case report and literature ...

*Pulse

Pulsus bisferiens: an unusual physical finding typically seen in patients with aortic valve diseases. If the aortic valve does ... It is seen in aortic valve stenosis. Pulsus paradoxus: a condition in which some heartbeats cannot be detected at the radial ... It is caused by a stiffened aortic valve that makes it progressively harder to open, thus requiring increased generation of ... such as aortic outflow tract obstruction, mitral stenosis, aortic arch syndrome) etc. A bounding pulse signifies high pulse ...

*Fetal aortic stenosis

... aortic valve does not fully open during development. The aortic valve is a one way valve that is located between the left ... resulting in systemic circulation failure in babies born with aortic valve stenosis. Fetal aortic valve stenosis can be ... Then a 0.014 inch guide wire is passed across the stenosis aortic valve, where a balloon is inflated to stretch the aortic ... Since the valve does not open properly in aortic stenosis, there is a decrease in the forward movement of blood into the aorta ...

*Streptococcus anginosus group

Rashid, R. M.; Salah, W.; Parada, J. P. (1 February 2007). "'Streptococcus milleri' aortic valve endocarditis and hepatic ...

*Lars Georg Svensson

2010 May;89(5):1443-7. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery;N ... "SOURCE" of enthusiasm for transcatheter aortic valve implantation; Circulation. 2010 Jul 6;122(1):8-10. Epub 2010 Jun 21. " ... for performing keyhole valve and aortic surgery; and has been involved from the beginning on the research of percutaneous ... simplified a method for preserving a patient's aortic valve and reimplanting it at the time of surgery so that patients ( ...

*John Fox (American football)

Fox then underwent successful aortic valve replacement surgery. He coached the Broncos to Super Bowl XLVIII in the 2013 season ... as Fox underwent an aortic valve replacement. Fox, while playing golf in North Carolina near his offseason home in Charlotte ... reported feeling dizzy and was taken to the hospital for examination where doctors told him not to put off valve replacement ...

*List of ICD-9 codes 390-459: diseases of the circulatory system

392) Rheumatic chorea (394) Diseases of mitral valve (395) Diseases of aortic valve (396) Diseases of mitral and aortic valves ... Aortic aneurysm and dissection (441.0) Aortic Dissection (441.3) Abdominal Aortic Aneurysm, ruptured (441.4) Abdominal aortic ... aortic, NOS (424.2) Valvular disorder, tricuspid, NOS (424.3) Valvular disorder, pulmonic, NOS (425) Cardiomyopathy (425.0) ... Aneurysm, w/o rupture (441.9) Abdominal Aortic Aneurysm, unspecified (442) Other aneurysm (443) Other peripheral vascular ...
Twenty-one patients (age four to 25 years) with bicuspid aortic valves proved by surgery and angiography (12) or angiography alone (9) were studied by echocardiography. Seventeen patients had aortic valve disease (11 stenosis, 6 incompetence) and four had coarctation of the aorta with normally functioning aortic valves. A comparison group of 16 patients (9 with aortic valve disease and 7 without aortic valve disease) who had proven tricuspid aortic valves was also studied. Echocardiograms in tricuspid aortic valve patients showed the closed position of the cusps near the middle of the aortic lumen. In contrast marked eccentricity of the aortic valve cusp echoes in diastole could be demonstrated in all with bicuspid aortic valves. The Eccentricity Index (½ aortic lumen diameter/minimum distance of the diastolic cusp echo from the nearest aortic margin) was low (range 1.0-1.25) with tricuspid aortic valves and high (range 1.5-5.6) with bicuspid aortic valves (P , 0.001). This index was not ...
Compared to patients with a tricuspid aortic valve, patients with a bicuspid valve appear to have ascending aorta dilation that is out of proportion to the severity of aortic stenosis or regurgitation; further, patients with a bicuspid aortic valve are thought to be at greater risk of progressive aortic dilation after aortic valve replacement. These observations form the basis of a proposed genetic aortopathy associated with bicuspid aortic valve, and are the basis of current guideline recommendations for more aggressive treatment of proximal ascending aorta dilation among patients with bicuspid aortic valve at the time of surgical aortic valve replacement. However, other data suggest that flow abnormalities related to fusion patterns may be a major contributor to aortic dilation among patients with bicuspid valve (e.g., MM Bissell, et al. Circ Cardiovasc Imaging 2013;6:499-507). The present study suggests that patients with a bicuspid aortic valve undergoing aortic valve replacement for aortic ...
Percutaneous aortic valve replacement (PAVR), also known as transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR), is the replacement of the aortic valve of the heart through the blood vessels (as opposed to valve replacement by open heart surgery). The replacement valve is delivered via one of several access methods: transfemoral (in the upper leg), transapical (through the wall of the heart), subclavian (beneath the collar bone), direct aortic (through a minimally invasive surgical incision into the aorta), and transcaval (from a temporary hole in the aorta near the belly button through a vein in the upper leg). Severe symptomatic aortic stenosis carries a poor prognosis. Until recently, surgical aortic valve replacement was the standard of care in adults with severe symptomatic aortic stenosis. However, the risks associated with surgical aortic valve replacement are increased in elderly patients and those with concomitant severe systolic heart failure ...
Calcific aortic valve disease (CAVD) is a chronic pathological process involving inflammation, fibrosis and calcification. Pharmacological intervention for prevention of CAVD progression remains unavailable. Calcified aortic valves display higher levels of oxidized low-density lipoprotein (oxLDL), and oxLDL has the potential to interact with Toll-like receptors (TLRs). Interleukin (IL)-37 is an anti-inflammatory cytokine and has been shown to inhibit TLR4-mediated inflammatory responses. We tested the hypotheses that oxLDL induces the osteogenic responses in human aortic valve interstitial cells (AVICs) via TLRs and that IL-37 suppresses the responses and may have therapeutic potential for suppression of CAVD progression.. Methods and Results: Human AVICs from normal valves were treated with oxLDL (20-80 μg/ml) for 72 hours in vitro. OxLDL up-regulated the expression of bone morphogenetic protein-2 (BMP-2) and alkaline phosphatase (ALP) in a dose-dependent fashion. Further, oxLDL induced NF-κB ...
The heart has four chambers and four valves. The valves open and close to keep blood flowing through the heart. One of these valves, the aortic valve, usually has three flaps, or leaflets. But sometimes people are born with an aortic valve that has two flaps. This is called a bicuspid aortic valve.. A bicuspid aortic valve makes certain heart problems, like aortic valve stenosis and aortic valve regurgitation, more likely.. In aortic valve stenosis, the valve has narrowed. Your heart has to work harder to pump blood throughout your body. Symptoms may include chest pain, dizziness, fainting, or shortness of breath. In aortic valve regurgitation, the valve does not close properly. Some of the blood leaks back (regurgitates) through the valve into the heart. Your heart has to work harder to pump blood throughout your body. Symptoms may include weakness and tiredness, shortness of breath, or an uneven heartbeat. Although you have a bicuspid heart valve, your heart can work normally. But you have a ...
Follow-up of a group of subjects in whom an aortic ejection sound was the only abnormal finding revealed a bicuspid aortic valve at necropsy or operation in 6 cases. High speed echophonocardiographic studies in 15 subjects with aortic stenosis and known to have bicuspid valves, showed the ejection sound to be exactly synchronous with final halting of the opening aortic valve cusps. Echocardiographic visualisation of the aortic valve from the apex, looking up the left ventricular outflow tract, showed valve echoes during systole indicating abnormal cusp configuration. This proved a more sensitive indicator of a bicuspid aortic valve than the finding of an eccentric aortic valve closure line. These findings were used to evaluate 37 subjects with the auscultatory finding of an isolated aortic ejection sound and the diagnosis of a non-stenotic bicuspid aortic valve was confirmed in 30. The usual cause of misdiagnosis was a sound associated with late tricuspid valve closure. The auscultatory finding ...
Currently, aortic valve replacement procedures require a sternotomy and use of cardiopulmonary bypass (CPB) to arrest the heart and provide a bloodless field in which to operate. A less invasive alternative to open heart surgery is transapical or transcatheter aortic valve replacement (TAVR), already emerging as a feasible treatment for patients with high surgical risk. The bioprosthetic valves are delivered via catheters using transarterial or transapical approaches and are implanted within diseased aortic valves. This paper reports the development of a new self-expanding stent for minimally invasive aortic valve replacement and its delivery device for the transapical approach under real-time magnetic resonance imaging (MRI) guidance. Made of nitinol, the new stent is designed to implant and embed a commercially available bioprosthetic aortic valve in aortic root. An MRI passive marker was affixed onto the stent and an MRI active marker to the delivery device. These capabilities were tested in ...
McKellar S.H., Tester D.J., Yagubyan M., Majumdar R., Ackerman M.J., Sundt T.M.. OBJECTIVES: Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection. Patient-specific prediction of the risk of developing thoracic aortic aneurysm, however, is imprecise. We hypothesize that genotypic variations in patients with bicuspid aortic valves contribute to this observed variability in aortic phenotype. We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. METHODS: We performed a targeted mutational analysis of NOTCH1 using genomic DNA from 48 unrelated subjects with concomitant bicuspid aortic valve and thoracic aortic aneurysm using denaturing high-performance liquid ...
The aortic valve allows oxygen-rich blood to flow from the heart to the aorta. It prevents the blood from flowing back from the aorta into the heart when the pumping chamber relaxes.. Bicuspid aortic valve is present at birth (congenital). An abnormal aortic valve develops during the early weeks of pregnancy, when the babys heart develops. The cause of this problem is unclear, but it is the most common congenital heart disease. It often runs in families.. The bicuspid aortic valve may not be completely effective at stopping blood from leaking back into the heart. This is called aortic regurgitation. The aortic valve may also become stiff and not open up as well, causing the heart to have to pump harder than usual to get blood past the valve (aortic stenosis). The aorta may become enlarged with this condition.. This condition is more common among males than females.. A bicuspid aortic valve often exists in babies with coarctation of the aorta and other diseases in which there is a blockage to ...
Transcatheter aortic valve replacement (TAVR) is a way to replace the aortic valve without open-heart surgery. This procedure is done to treat aortic valve stenosis.. TAVR is often done through an incision (cut) in the groin. But sometimes a small cut is made in the chest. The doctor uses a tube called a catheter and tools that fit inside the catheter. The doctor puts the catheter into a blood vessel and moves it through the blood vessel and into the heart. The artificial valve fits inside the catheter. The doctor then moves the new valve into the damaged aortic valve. The artificial valve expands and takes the place of the damaged valve.. You may have general anesthesia, which makes you sleep during the surgery. Or you may get a sedative that will help you relax.. To see if TAVR might be a choice for you, a team of doctors will check many things about your heart and your overall health. Together you can decide if you want to have the procedure.. ...
Repair of the Transcatheter aortic valve is a minimally invasive procedure. This technique is used without removing it to treat or restore old and damaged aortic valve. The technique used to insert a new valve to the place of the old aortic valve is called the Transcatheter aortic valve replacement system. Between the left atrium and the left ventricle is the mitral valve. Mitral valve disorder is a condition in which the valve ceases working properly, leading to abnormal blood flow. This abnormal blood flow can lead to diseases such as prolapse of the mitral valve and regurgitation of the mitral valve.. Renub Research latest study report "Transcatheter Heart Valve Replacement Market, Volume, Share by Materials (Mechanical and Tissue) Position (Transcather Mitral Valve Replacement and Transcatheter Aortic Valve Replacement), Region (United States, Germany, China, France, Italy, Japan, Spain, United Kingdom, India and Brazil), Company Analysis" provides a detailed and comprehensive insight of the ...
Transcatheter aortic valve replacement (TAVR - also known as TAVI or transcatheter aortic valve implantation) is a new technology for use in treating aortic stenosis. A bioprosthetic valve is inserted percutaneously using a catheter and implanted in the orifice of the native aortic valve ...
Valve replacement surgery is the replacement of one or more of the heart valves with either an artificial heart valve or a bioprosthesis (homograft from human tissue or xenograft e.g. from pig). It is an alternative to valve repair. There are four procedures Aortic valve replacement Mitral valve replacement Tricuspid valve replacement Pulmonary valve replacement Current aortic valve replacement approaches include closed heart surgery, Very invasive cardiac surgery (VICS) and Very invasive, Scapulae-based aortic valve replacement. Catheter replacement of the aortic valve (called trans-aortic valve replacement or implementation [TAVR or TAVI]) is a minimally invasive option for those suffering from aortic valve stenosis. TAVR is commonly performed by guiding a catheter from the groin to the narrowed valve via the aorta using realtime x-ray technology. A metal stent containing a valve is then deployed using a balloon to press the stent into the valve in effect opening the stenosed (or narrowed) ...
Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in ,50% of BAV patients, and accounts for ~40% of the ,30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability.. The Specific Aims of this study are:. ...
Patients who are suffering with severe aortic stenosis, which is the narrowing of the hearts aortic valve opening that restricts blood flow, have a minimally invasive surgical option available at the Heart and Vascular Center at Manatee Memorial Hospital. Transcatheter Aortic Valve Replacement (TAVR) is an advanced heart valve replacement procedure that offers new hope to patients who have aortic valve stenosis and are at high or extreme risk for open-heart surgery. TAVR patient Eugene Vaadi describes his experience:
Aortic Valve Replacement India offers information on Aortic Valve Repair or replacement in India, Aortic Valve Repair cost India, Aortic Valve Replacement hospital in India, Delhi, Mumbai, Chennai, Hyderabad & Bangalore.
... (TAVI), also referred to as transcatheter aortic valve replacement (TAVR), is a procedure that replaces your diseased aortic valve with a man-made valve.
Bicuspid aortic valves (BAVs) represent a wide morphologic and functional spectrum. In coarctation of the aorta, BAVs are common, but the proportion of BAV subtypes and their relation to aortic dimensions and development of late valve dysfunction are unknown. Sixty-two cardiovascular magnetic resonance investigations of patients with coarctation of the aorta were reviewed with respect to aortic valve morphology, aortic valve function, and aortic dimensions. BAVs were identified in 45 patients (72.6 %), of which 13 (20.9 %) were type-0 (two commissures), 28 (45.1 %) type-1 (three commissures but fusion of one commissure with a raphe) and 4 (6.5 %) valves were bicuspid but not possible to classify further. Patients with BAVs type-0 had larger dimensions in their sinus of Valsalva (35.5 ± 6.8 vs. 29.7 ± 2.7 mm, p = 0.002), ascending aorta (33.1 ± 6.2 vs. 26.0 ± 4.3 mm, p = 0.005) and sino-tubular junction (29.3 ± 7.4 vs. 24.2 ± 3.5 mm, p = 0.040) compared with tricuspid aortic valves (TAVs). ...
Methods and Results-Data were obtained using the national inpatient sample between the years 2011 and 2014. We used the International Classification of Diseases, Ninth Edition, Clinical Modification procedure codes 350.5 and 350.6 to identify patients undergoing transcatheter aortic valve replacement. Primary outcome of interest was in-hospital mortality. A 2-tailed P value ,0.01 was considered to denote statistical significance for all analyses. We identified 42 189 patients who underwent transcatheter aortic valve replacement between the years 2011 and 2014. Of these, 62.1% (n=26 229) had no CKD/ESRD, 33.7% (n=14 252) had CKD, and 4% (n=1708) had ESRD. Patients with CKD or ESRD had greater in-hospital mortality, hospital length of stay, hemorrhage requiring transfusion, and permanent pacemaker implantation (P,0.001). ...
BACKGROUND: Patients undergoing surgical aortic valve replacement (SAVR) are considered at high risk of infective endocarditis (IE). However, data on the risk of IE following transcatheter aortic valve replacement (TAVR) are sparse and limited by the lack of long-term follow-up as well as a direct comparison with patients undergoing SAVR.. OBJECTIVES: This study sought to investigate the long-term incidence of IE in patients undergoing TAVR and to compare the long-term risk of IE with patients undergoing isolated SAVR.. METHODS: In this nationwide observational cohort study, all patients undergoing TAVR and isolated SAVR from January 1, 2008, to December 31, 2016, with no history of IE and alive at discharge were identified using data from Danish nationwide registries.. RESULTS: A total of 2,632 patients undergoing TAVR and 3,777 patients undergoing isolated SAVR were identified. During a mean follow-up of 3.6 years, 115 patients (4.4%) with TAVR and 186 patients (4.9%) with SAVR were admitted ...
Since the pioneering works by Andersen et al. (1) and Cribier et al. (2), transcatheter aortic valve replacement (TAVR) has become a well-established and evidence-based therapy for severe and symptomatic aortic stenosis in patients at higher surgical risk. TAVR has been associated with lower all-cause mortality than best medical therapy in patients who were ineligible for surgical aortic valve replacement (SAVR) (3), as well as noninferiority or even superiority to SAVR with respect to all-cause mortality in patients at high surgical risk (4,5). In patients at intermediate risk, TAVR has been reported non-inferior to SAVR regarding death from any cause or disabling stroke (6). In addition, the first randomized trial comparing TAVR and SAVR in all-comer patients indicated that these findings may apply to patients at lower surgical risk (7). Furthermore, a meta-analysis of the 4 randomized clinical trials including 3,806 patients comparing TAVR and SAVR showed that TAVR was associated with a 13% ...
Risk assessment models for transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement in high-risk patients and TAVR versus palliation in inoperable patients are based on surgical data and have limited discrimination and calibration in the setting of TAVR. Several novel risk models specifically designed for TAVR have improved discrimination over existing models but require further validation. Several clinical and echocardiographic variables, such as chronic lung disease, mitral regurgitation, and stroke volume index, influence outcomes. This article reviews current and novel risk models and important predictors of TAVR outcomes and proposes a framework to integrate them into clinical decision-making for patients with severe, symptomatic aortic stenosis.
Transcatheter aortic valve replacement (TAVR) continues to grow and flourish with more than 300,000 procedures performed to date worldwide and an expected expansion over the next decade. Currently restricted to high-risk and otherwise inoperable patients (1), recent data favor TAVR rather than surgical aortic valve replacement in intermediate risk patients (2,3). A combination of new-generation devices, increased experience, better understanding of the disease, and improved screening is associated with improved outcomes, and there is a continuous trend to simplifying the procedure (4). Consequently, among early major issues associated with TAVR, paravalvular regurgitation may now be considered as a thing of the past and bleeding/vascular complications are on the decrease thanks to smaller size devices and better selection. Hence, overt stroke remains the most feared complication and is strongly associated with morbidity and mortality.. Early randomized studies have raised concerns about stroke ...
The perfect heart valve substitute has not yet been developed and matching the patient to existing options to optimize survival and reduce valve-related complications remains challenging. The choices for aortic valve replacement (AVR) are mechanical valves, bioprosthetic valves, and biological valves such as aortic valve homograft and the Ross procedure (pulmonary autograft). The latter is a complex operation because it transfers the patients own pulmonary valve into the aortic position and uses a biological valve to replace the pulmonary valve, transforming a single-valve disease into a 2-valve disease. These considerations are not important to most North American patients who undergo AVR because they are older and the durability of bioprosthetic valves in this age group is excellent (1,2). The risk of bioprosthetic valve failure 20 years after AVR is ,10% in patients 70 years of age and older (1,2). A report based on the Society of Thoracic Surgeons Database from January 1997 to December 2006 ...
The aortic valve controls blood flow from the heart to the body. In some people, the valve becomes stiff and has trouble opening. This condition is called aortic stenosis. It is a progressive disease. In aortic stenosis, the heart has to work harder to push blood through the valve to the rest of the body. Over time, the extra stress can cause the heart muscle to get weaker. People who have aortic stenosis can feel tired and short of breath and have chest pain and fainting.. At Hackensack University Medical Center, our multidisciplinary team is offering transcatheter aortic valve replacement (TAVR) as a life-changing option for many patients with aortic stenosis. TAVR is a minimally invasive procedure that allows our cardiac experts to repair a valve without removing it. If you have aortic stenosis and your doctor feels that traditional open-heart surgery may be a risk, TAVR can be an option for you. TAVR is sometimes recommended for people who are older, have a weaker heart, had previous heart ...
OBJECTIVE: There is an ongoing discussion regarding the mechanism of aortic dilatation in bicuspid aortic valve (BAV) disease, that is, is this a hemodynamic effect or related to an inborn weakness of the aortic wall? This study evaluated the possibility of BAV morphology being related to ascending aorta morphology as such a correlation would strengthen the idea that hemodynamic alterations cause the dilatation of the aorta. METHODS: The morphology of the ascending aorta of 300 patients admitted for aortic valve and/or ascending aorta disease was evaluated by echocardiography and related to the surgeons inspection of the aortic valve. RESULTS: A tricuspid aortic valve (TAV), BAV, or unicuspid aortic valve (UAV) was present in 130, 160, and 10 patients, respectively. Ascending aortic aneurysm was more common in patients with BAV compared with TAV (36% and 12%, respectively; p < 0.001), while ectasia of the aorta was similarly common (8% in both groups). Aortic stenosis or regurgitation was ...
Aortic valve replacement is recommended as standard management for patients with symptomatic aortic valve disease, independent of age.19-22 Following surgery, patients usually have a dramatic improvement in their cardiovascular symptoms and have improved survival rates at 5, 10, and 15 years.23,24 Persistent AV block requiring permanent pacing is an uncommon but serious postoperative complication which increases mechanical ventilation times, intensive care unit stay, and overall hospital day.12-15. Previous studies have already evaluated perioperative risk predictors of PPI after cardiac surgery in large cohorts of patients with different diseases.12-18 However, there are only scanty data on the development of irreversible AV block requiring PPI after aortic valve replacement, especially in the presence of isolated aortic regurgitation or in the case of combined aortic stenosis and regurgitation.. In our series of 276 patients (39% with isolated aortic stenosis, 29% with isolated aortic ...
Minimally invasive aortic valve replacement versus aortic valve replacement through full sternotomy: the Brigham and Womens Hospital experience
Valve replacement surgery has a high rate of success and a low risk of causing other problems if you are otherwise healthy. Although most people have successful outcomes, there is a risk of death and serious problems during surgery. Valve replacement surgery is high-risk for people who have a failing left ventricle and who have had a heart attack. About 5 or less out of 100 people who have valve surgery die.footnote 3. If you have severe aortic valve regurgitation or stenosis, the risks of not replacing the valve may be greater than the risks of surgery, unless you have other health problems that make surgery too dangerous.. Even if valve replacement surgery is a success, you may have problems after surgery, such as:. ...
Objectives. This study was undertaken to elucidate the prevalence of aortic valve abnormalities in the elderly.. Background. The age of persons treated actively for valve disorders is increasing. More information is needed about the prevalence of aortic valve disease in old age.. Methods. Randomly selected men and women in the age groups 75 to 76, 80 to 81 and 85 to 86 years (n = 501) participating in the Helsinki Ageing Study were studied with imaging and Doppler echocardiography. Additionally, 76 persons 55 to 71 year of age were included. The systolic aortic valve area was calculated by the continuity equation. The velocity ratio (peak velocity in the left ventricular outflow tract/peak velocity across the aortic valve) was a supplementary criterion for aortic stenosis. Valve regurgitation and cusp calcification were assessed visually.. Results. Evaluation of the aortic valve was possible in 552 persons (96%). Mild calcification was found in 222 (40%) and severe calcification in 72 (13%). Two ...
Aortic valve calcification (AVC) without outflow obstruction (stenosis) is common in the elderly and increases the risk of cardiovascular morbidity and mortality. Although high blood pressure (BP) measured at the doctors office is known to be associated with AVC, little is known about the association between 24-hour ambulatory BP (ABP) and AVC. Our objective was to clarify the association between ABP variables and AVC. The study population consisted of 737 patients (mean age, 71±9 years) participating in the Cardiovascular Abnormalities and Brain Lesions study who underwent 24-hour ABP monitoring. Each aortic valve leaflet was graded on a scale of 0 (normal) to 3 (severe calcification). A total valve score (values 0-9) was calculated as the sum of all leaflet scores. Advanced AVC (score ≥4) was present in 77 subjects (10.4%). All of the systolic ABP variables (except systolic BP nocturnal decline) and mean asleep diastolic BP were positively associated with advanced calcification, whereas normal
Technology Assessment Unit of the McGill University Health Centre (MUHC) Surgical aortic valve replacement with the ATS Enable sutureless aortic valve for aortic stenosis Report number: 71 DATE: September
Approach and Results-Here, we show that Wnt/β-catenin signaling inhibits Sox9 nuclear localization and proteoglycan expression in cultured chicken embryo aortic valves. Loss of β-catenin in vivo in mice, using Periostin(Postn)Cre-mediated tissue-restricted loss of β-catenin (Ctnnb1) in valvular interstitial cells, leads to the formation of aberrant chondrogenic nodules and induction of chondrogenic gene expression in adult aortic valves. These nodular cells strongly express nuclear Sox9, and Sox9 downstream chondrogenic extracellular matrix genes, including Aggrecan, Col2a1, and Col10a1. Excessive chondrogenic proteoglycan accumulation and disruption of stratified extracellular matrix maintenance in the aortic valve leaflets are characteristics of myxomatous valve disease. Both in vitro and in vivo data demonstrate that the loss of Wnt/β-catenin signaling leads to increased nuclear expression of Sox9 concomitant with induced expression of chondrogenic extracellular matrix proteins.. ...
Approximately 300,000 patients in the United States have aortic stenosis (narrowing of the aortic heart valve), and about one third of these patients are too sick or too old to undergo surgical replacement. Under the leadership of NewYork-Presbyterian Hospitals Division of Cardiothoracic Surgery, Transcatheter aortic valve replacement (TAVR) has been under study as a less invasive alternative for these patients.
0008]The three major factors to preserve the function of the aortic valve include maintaining the appropriate diameter of the sinotubular junction and the aortic annulus, and state of the leaflets per se. Only when the functions of these three factors are optimally recovered, the aortic valve function can be successfully restored. Existing methods to repair the aortic valve havent met these requirements entirely. For example, resuspension of the aortic valve leaflets inside an artificial vascular conduit has been suggested as an effective method of repairing ascending aortic aneurysm due to Marfan syndrome with morphologically normal aortic leaflets (David T. E. `Aortic valve repair in patients with Marfan syndrome and ascending aorta aneurysms due to degenerative disease` J. Card. Surg. 1994; 9(2 Suppl):182-7). However, this method is applicable only to limited situations. One drawback is that the sinus portion in the proximal aortic root has to be removed. Furthermore, this method may lead to ...
Objectives. Primary objective:. To determine if rivaroxaban (Xarelto) is feasible and safe for prevention of major complications in patients undergoing a mechanical aortic heart valve replace-ment.. Secondary objectives:. To identify the value of molecular markers suitable for monitoring of anticoagulation effectiveness of rivaroxaban and its correlation with transcranial Doppler emboli count in patients undergoing a mechanical aortic heart valve replacement.. Design This is a prospective, open-label phase 2 pilot study with independent evaluation of all outcomes and a historical control group.. Number of patients 30 in experimental group (patients in the centers registry database serve as control group).. Main eligibility criteria All patients between 18 and 70 years old receiving a mechanical aortic valve replacement with a pre-operative left ventricular ejection fraction ,/=35%.. Interventions Experimental: Rivaroxaban 20mg p.o., once daily, for six months Historical control: Phenprocoumon ...
Until now, the only treatment for severe aortic stenosis has been open aortic valve replacement, but if a cardiac surgeon determines that you are not a candidate for open-heart surgery and if medicine is not helping you feel better, the TAVR procedure may be an alternative. TAVR is approved for patients who have shortness of breath or chest pain from a severely narrowed aortic valve and who are to sick for an open aortic valve operation.Most people who have this procedure are in their 70s or 80s and often have other medical conditions that make them a better candidate for this type of surgery. ...
TY - JOUR. T1 - Surgical Aortic Valve Replacement-Clinical Update on Recent Advances in the Contemporary Era. AU - Ramakrishna, Harish. AU - Patel, Prakash A.. AU - Gutsche, Jacob T.. AU - Vallabhajosyula, Prashanth. AU - Szeto, Wilson Y.. AU - MacKay, Emily. AU - Feinman, Jared W.. AU - Shah, Ronak. AU - Zhou, Elizabeth. AU - Weiss, Stuart J.. AU - Augoustides, John G.. PY - 2016/12/1. Y1 - 2016/12/1. KW - bleeding. KW - cardiopulmonary bypass. KW - clinical outcomes. KW - duration of stay. KW - femoral artery. KW - femoral vein. KW - full sternotomy. KW - guidelines. KW - mechanical ventilation. KW - meta-analysis. KW - minimally invasive aortic valve replacement. KW - mortality. KW - right anterior thoracotomy. KW - stroke. KW - surgical aortic valve replacement. KW - sutureless aortic valve. KW - transesophageal echocardiography. KW - transfusion. KW - upper hemisternotomy. UR - http://www.scopus.com/inward/record.url?scp=84995489189&partnerID=8YFLogxK. UR - ...
FRIDAY, Feb. 2, 2018 (HealthDay News) - The presence of depressive symptoms among older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement increases the risk of mortality, according to research published online Jan. 17 in JAMA Cardiology.. Laura M. Drudi, M.D., from Jewish General Hospital in Montreal, and colleagues assessed depressive symptoms in preplanned analysis of the Frailty Aortic Valve Replacement prospective cohort study (14 centers in three countries from Nov. 15, 2011, through April 7, 2016). Participants included individuals (mean age, 81.4 years) who underwent TAVR or SAVR aortic valve replacement.. Among 1,035 participants, the researchers found that 31.5 percent had a positive screening result for depression, but only 8.6 percent had depression documented in their clinical record. Baseline depression was associated with mortality at one month (odds ratio, 2.20) and at 12 months (odds ratio, 1.532), after adjusting for clinical and geriatric ...
Trans Aortic Valve Implantation is done by administering local anesthesia by an experienced cardiac surgeon and typically takes between 45 to 60 minutes. TAVI is a minimally invasive procedure to repair the aortic valve functioning without removing the old, damaged valve. Instead, bioprosthetic valve is implanted as a replacement valve. TAVI involves the insertion of the catheter via either of the three approaches (Transfemora, Transapical and Transaortic) to access the heart. A hollow tube, called catheter, is inserted through the incision and guided to the heart. Ultrasound (high frequency sound wave imaging) and X-ray imaging is used by the doctor to guide the catheter during the procedure. After carefully positioning the catheter, the replacement valve is passed through it. This valve pushes away the damaged vessel and uses it as an anchor to sit in its place. Once the doctor is sure the valve is securely in place, the catheter is withdrawn. One of the advantages of this technique is that ...
Aortic valve and mitral valve are commonly replaced valves. The pulmonary and the tricuspid valve replacements also are uncommon among adults.. Replacing narrowed valve:. Most common valve procedure is the aortic valve replacement Singapore for the aortic stenosis, and narrowing of aortic valve. The mitral stenosis is one more condition that at times need valve replacement method.. Replacing leaky valve:. The aortic regurgitation, (at times referred as the aortic insufficiency) is one common valve problem, which might need valve replacement. The regurgitation means valve allows the blood to go back through valve and in heart rather than moving it ahead and out to your body. The aortic regurgitation will eventually lead to the heart failure.. ...
Abstract: Background: Aortic valve replacement (AVR) using extracorporeal circulation is currently the treatment of choice for symptomatic aortic stenosis. However, patients with multiple high-risk comorbid conditions may benefit from reduced ECC time by a simplified and faster resection in conjunction with quick sutureless valve implantation. Methods: A prototype of a new minimally invasive aortic valve resection tool equipped with rotating and foldable Nitinol cutting edges was designed. Commercially available aortic valve bioprostheses were artificially calcified (group 1: moderate calcified, n =8, group 2: severely calcified, n =8). In vitro resection was performed using a 21mm cutting blade. Resection time (RT), maximum turning moment (MTM) and number of required rotations (NR) were measured. Furthermore, particle generation during the process of cutting was obtained and quantified. Results: Aortic valve cutting could be obtained without any complications in all cases. Cutting process ...
Calcific aortic valve disease (CAVD) affects a large number of elder people (65 or older) and is one of the leading cardiovascular diseases in older adults in industrial countries.1, 2 This disease is an active pathobiological process involving fibrosis and calcification of aortic valve leaflets.3 Severe CAVD causes morbidity and results in the second most common cardiovascular surgery performed.4 The growing prevalence of this disease, associated with prolongation of the human life span, and the unavailability of pharmacological intervention for limitation of disease progression emphasize the importance of investigations of pathobiological mechanisms. In particular, it is critical to elucidate the cellular and molecular mechanisms by which aortic valve leaflets become fibrotic and calcified.. Aortic valve interstitial cells (AVICs) play an important role in maintaining valvular structure and function. In normal human aortic valves, AVICs primarily assume a fibroblastic phenotype.5 They produce ...
... is an abnormality of the aortic valve that allows blood to flow backwards through the valve. The aortic valve normally allows blood to pass from the left ventricle into the aorta. From the aorta blood flows to the rest of the body. In aortic valve regurgitation, blood that is supposed to flow up through the aorta flows backward through the valve into the left ventricle of the heart.. ...
Detailed knowledge of aortic root geometry is a prerequisite to anticipate complications of transcatheter aortic valve (TAV) implantation. We determined coronary ostial locations and aortic root dimensions in patients with aortic stenosis (AS) and compared these values with normal subjects using computed tomography (CT). One hundred consecutive patients with severe tricuspid AS and 100 consecutive patients without valvular pathology (referred to as the controls) undergoing cardiac dual-source CT were included. Distances from the aortic annulus (AA) to the left coronary ostium (LCO), right coronary ostium (RCO), the height of the left coronary sinus (HLS), right coronary sinus (HRS), and aortic root dimensions [diameters of AA, sinus of Valsalva (SV), and sino-tubular junction(STJ)] were measured. LCO and RCO were 14.9 ± 3.2 mm (8.2-25.9) and 16.8 ± 3.6 mm (12.0-25.7) in the controls, 15.5 ± 2.9 mm (8.8-24.3) and 17.3 ± 3.6 mm (7.3-26.0) in patients with AS. Controls and patients with AS had ...
Aortic Valve Replacement in Bicuspid Aortic Valve with a Single Coronary Artery. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Introduction and objectives. Patients with aortic valve disease and a dilated ascending aorta are usually treated with a composite graft comprising a valve and conduit. We review here the results of treatment with an aortic root homograft as a valid alternative. Patients and method. Twenty-two consecutive patients with a mean age of 64.8 (8.8) years were studied. Mean ascending aorta dilation was 54.55 mm, aortic valve insufficiency was present in 16 patients, and a combined lesion was present in 6. In all cases a cryopreserved aortic root homograft was used to replace the aortic valve and ascending aorta. In 9 cases a Dacron conduit was used beyond the sinotubular junction to restore continuity between the homograft and the native aorta. Results. All patients survived surgery. One patient had postoperative systemic inflammatory response syndrome and one patient was re-explored for excessive bleeding. Mean duration of follow-up was 12.1 months (range 2-36 months). No patient was given ...
BACKGROUND: Aortic regurgitation (AR) is an important limitation of transcatheter aortic valve replacement (TAVR) with ill-defined predictors and unclear long term impact on outcomes. We sought to analyze currently published literature to establish t
Previously, the alternative to surgical AVR in patients deemed too "high risk" for surgery was balloon aortic valvuloplasty (BAV). Introduced in the mid-1980s, BAV as a therapy has been limited by high rates of both early and late restenosis (3, 4). BAV is a procedure in which the stenosed aortic valve is crossed with a straight wire in a retrograde fashion, and then exchanged for a stiff 0.035" guidewire upon which a 20- to 23-mm diameter balloon catheter is tracked up across the aortic valve. With the initiation of rapid pacing of the right ventricle, balloon inflation across the stenosed aortic valve is performed. In addition to high rates of restenosis, the procedural risks of BAV include embolic stroke, vascular complications, and severe aortic insufficiency. Currently the ACC/AHA guidelines limit the use of BAV to either cases of palliation or situations "to bridge" unstable patients to a more definitive therapy, such as AVR (5 ...
Adequate presentation of risks and benefits of medical therapies is essential to informed decision making by patients. Transcatheter aortic valve replacement (T
Patients with stenotic or regurgitant aortic valve disease appear to cleave multimers of Von Willebrand factor (HMW-multimer), presumably due to high-shear stresses and non-laminar flow. Van Belle and colleagues hypothesized that transcatheter aortic valve replacement (TAVR) would correct this process, but that significant residual paravalvular leak (PVL) following TAVR would abrogate this corrective effect. Moderate […]. Read More…. ...
Learn how MedStar Heart & Vascular Institute uses transcatheter aortic valve replacement (TAVR) to treat some patients with severe aortic stenosis.
Quadricuspid aortic valve (QAV) is a rare congenital anomaly frequently associated with other anomalies particularly coronary anomalies. It may be detected on transthoracic or transesophageal echocardiography. We present here a case report of a 27-year-old male patient with a QAV, the valve being regurgitant and requiring aortic valve replacement. It has been reported as isolated case reports in the literature and various theories exist to the development of QAV. The diagnosis requires a high degree of suspicion and a detailed assessment, and if asymptomatic, then patients need to be carefully followed up for the development of aortic regurgitation ...
Although occlusion of the coronary arteries during transcatheter aortic valve replacement is rare, the mortality is high. In this review, we discuss the prevention and management of this complication. Occlusion of coronary ostia is a very rare, but serious, complication of transcatheter aortic valve replacement (TAVR). Although reported as only occurring in ,1% of TAVR cases, it carries a high risk of fatality, with some series reporting a mortality rate as high as 40%. We present the management of an occluded left coronary artery after a self-expanding TAVR, and review the incidence, prevention, and management of this complication ...
The management of aortic valve disease has been improved by accurate diagnosis and assessment of severity by echocardiography and advanced imaging techniques, efforts to elicit symptoms or objective markers of disease severity and progression, and consideration of optimum timing of aortic valve replacement, even in elderly patients. Prevalence of calcific aortic stenosis is growing in ageing populations. Conventional surgery remains the most appropriate option for most patients who require aortic valve replacement, but the transcatheter approach is established for high-risk patients or poor candidates for surgery.. ...
Causes and Effects of Aortic Valve Disease - Some causes of aortic valve disease include calcium buildup, wear and tear or a misshapen valve. Learn the other causes of aortic valve disease.
Chlamydia pneumoniae has previously been demonstrated in the atherosclerotic lesions of various arteries, including the coronary arteries, and has been proposed to play a role in the pathogenesis of atherosclerosis. A prospective study of the incidence of C. pneumoniae in the sclerotic valves of patients undergoing aortic valve replacement because of aortic stenosis and in the aortic valves of cases dying of non-cardiac reasons and undergoing forensic autopsy was undertaken. The results were correlated to serological markers of past (IgG) or persistent (IgA) C. pneumoniae infection. C. pneumoniae, as determined by the polymerase chain reaction (PCR), was detected in the aortic valve in 19/39 (49%) patients and in 1/11 (9%) autopsy controls (p = 0.018) and confirmed by electron microscopy in one patient. There was no significant difference in the incidence rate of IgG or IgA antibody positivity between PCR-positive and PCR-negative cardiac patients. These results extend the hypothesis of a ...
In this paper, performance of aortic heart valve prosthesis in different geometries of the aortic root is investigated experimentally. The objective of this investigation is to establish a set of parameters, which are associated with abnormal flow patterns due to the flow through a prosthetic heart valve implanted in the patients that had certain types of valve diseases prior to the valve replacement. Specific valve diseases were classified into two clinical categories and were correlated with the corresponding changes in aortic root geometry while keeping the aortic base diameter fixed. These categories correspond to aortic valve stenosis and aortic valve insufficiency. The control case that corresponds to the aortic root of a patient without valve disease was used as a reference. Experiments were performed at test conditions corresponding to 70 beats/min, 5.5 L/min target cardiac output, and a mean aortic pressure of 100 mmHg. By varying the aortic root geometry, while keeping the diameter of ...
The aortic heart valve undergoes geometric and mechanical changes over time. The cusps of a normal, healthy valve thicken and become less extensible over time. In the disease calcific aortic stenosis (CAS), calcified nodules progressively stiffen the
One of our new heart treatments is the Transcatheter aortic valve replacement. It is one of the minimally invasive heart procedures. Find out more.
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Approach and Results-A bacterial artificial chromosome of the human S100/calgranulin gene cluster containing the genes and regulatory elements for S100A8, S100A9, and S100A12 was expressed in C57BL/6J mouse (hBAC-S100) to generate a novel humanized mouse model. CKD was induced by ureteral ligation, and hBAC-S100 mice and wild-type mice were studied after 10 weeks of chronic uremia. hBAC-S100 mice with CKD showed increased fibroblast growth factor 23 in the hearts, left ventricular hypertrophy, diastolic dysfunction, focal cartilaginous metaplasia, and calcification of the mitral and aortic valve annulus together with aortic valve sclerosis. This phenotype was not observed in wild-type mice with CKD or in hBAC-S100 mice lacking the receptor for advanced glycation end products with CKD, suggesting that the inflammatory milieu mediated by S100/receptor for advanced glycation end products promotes pathological cardiac hypertrophy in CKD. In vitro, inflammatory stimuli including interleukin-6, tumor ...
This stock medical exhibit demonstrates bacterial endocarditis from trauma with damage to the aortic valve. The upper two images present aortic valve function in a normal and undamaged heart. On the upper left, the valve is open, allowing blood flow from the left ventricle to the aorta. At the upper right, the valve is closed, preventing back flow of blood into the ventricle. The lower two images show what happens when the aortic valve is damaged. In the lower left image, a bacteria infection on the valve inhibits it from functioning properly. At the lower right, the defective aortic valve is not able to close properly, allowing blood to flow back into the ventricle.
Rupture of the aortic valve is an infrequently reported condition despite the variety of causes.1, 2, 3, 4, 5, 6, 7, 8 In the majority of instances the etiology is valve damage as a result of syphilis, bacterial endocarditis or arteriosclerosis, unless there is a history of specific external trauma. A few reports1, 2, 3, 4 are found in which rupture of the valve occurred spontaneously or after varying degrees of physical exertion. In the case reported below, rupture of the commissural attachment of the posterior and right anterior cusps of the aortic valve was found to be due to ...
TY - JOUR. T1 - Do differences in early hemodynamic performance of current generation biologic aortic valves predict outcomes 1 year following surgery?. AU - Thalji, Nassir M.. AU - Suri, Rakesh M.. AU - Michelena, Hector I. AU - Greason, Kevin L.. AU - Dearani, Joseph A.. AU - Daly, Richard C.. AU - Joyce, Lyle D.. AU - Stulak, John M.. AU - Burkhart, Harold M.. AU - Li, Zhuo. AU - Schaff, Hartzell V. PY - 2015. Y1 - 2015. N2 - Objective: Small early postoperative hemodynamic differences were noted in a randomized comparison of 3 current-generation bioprosthetic aortic valves. Whether these differences persist and influence clinical outcomes 1 year following implantation is unknown. Methods: Three hundred adults with severe aortic stenosis undergoing valve replacement were randomized to receive the Epic (St Jude, St Paul, Minn) (n = 99), Magna (Edwards LifeSciences Inc, Irvine, Calif) (n = 100), or Mitroflow (Sorin Biomedica Spa, Saluggio, Italy) (n = 101) bioprostheses. Hemodynamic valve ...
The Edwards SAPIEN Valve, now available at UW Hospital and Clinics in Madison, Wisconsin, is the first transcatheter aortic valve replacement (TAVR) therapy approved for use in the U.S., and select hospitals are now performing the procedure on qualified patients.
Minimally invasive surgery is associated with a faster postoperative recovery because of reduced postoperative pain and improved respiratory function, especially in elderly patients. We began using a minimally invasive approach ismall parasternal incision jfor isolated aortic valve replacement iMICS AVR jfrom January 2011. Between January 2011 and February 2012, 32 patients underwent MICS AVR surgery. The mean age was 73 years irange 57-85 years j;69% were women. MICS AVR was performed through a skin incision of 6.5 }0.5cm along the third intercostal space. Cardiopulmonary bypass was established through the right femoral artery and vein. The patients were cooled to 28 , the aorta was crossclamped with a flex clamp, and antegrade cardioplegic solution was given into the aortic root or selectively into the coronary ostia. The aortic valve procedure was performed in a standard fashion. If the distance to the aortic valve was too far, we used surgical instruments for minimally invasive surgery. ...
Depending on the extent of your valve disease, you may need to have the valve repaired or replaced. To repair the valve, your surgeon may perform a commissurotomy or implant a valve ring. A commissurotomy is performed for a tight valve (stenosis). The valve leaflets are cut to loosen the valve slightly, allowing blood to pass easily. Another type of valve repair is a valve ring annuloplasty, which is sewn in place when the valve is leaking (regurgitant or insufficient). The valve leaflets are tucked in place with the ring.. Often the valve cannot be repaired and the surgeon must replace the damaged valve with a tissue (bioprosthetic) or mechanical valve. Tissue valve are valves from animals (e.g., cow, pig). They generally do not require long-term anticoagulation and are not as durable as mechanical valves. Mechanical valves are made from materials such as plastic or metal. They require long-term anticoagulation and are considered extremely durable, lasting longer than tissue valves.. Your ...
The aortic valve can become leaky due to a problem with the valve itself or with the first part of the aorta called the aortic root. Approximately half of the causes of aortic regurgitation are due to this aortic root being dilated. The cause of the aortic root dilation is idiopathic in most cases but can otherwise result from high blood pressure, ageing or a weakness in the aortic wall. In bicuspid aortic valves (from birth) the aortic valve itself can become weaker. Connective tissue disorders such as Marfans and ankylosing spondylitis are also associated with aortic regurgitation.. ...
Author: Mohamed, Salah A. et al.; Genre: Journal Article; Published in Print: 2006-07-14; Keywords: NOTCH1; Bicuspid aortic valve; Valve calcification; Missense mutations; Title: Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve
Renin-angiotensin system blockade with ACE inhibitors or angiotensin receptor blockers was found to be associated with increased survival rates after surgical aortic valve replacement in patients with aortic stenosis. (Ann Intern Med. 2014 Nov 18;161(10):699-710) ...
RadcliffeCardiology latest cardiology news Results from post-market study of the direct flow medical aortic heart valve system demonstrate consistently positive outcomes at 30 days
This stock medical exhibit depicts normal aortic valve function. A cross-sectional view of the heart shows the direction of blood flow from the left ventricle into the aorta. The aortic valve is hown in both open and closed positions.
MARQUETTE - For those with cardiovascular problems who are deemed too weak or frail for open heart surgery, UP Health System - Marquette has an alternative solution: the Transcatheter Aortic Valve Replacement procedure. TAVR is a minimally invasive surgery that repairs the heart valve without removing the original, damaged valve. It calls for wedging a replacement valve in the aortic valves place. Similar to a stent, the TAVR procedure delivers the replacement valve to the valve site through a catheter. "People who have severe aortic stenosis have symptoms of chest pain, shortness of breath or dizziness with exertion," said Dr. Kris Dosh of UP Health System - Marquette. "Those symptoms almost always get better with the valve replacement … There is also a survival benefit.". The original trials for TAVR were designed to look at people who werent candidates for surgical valves and to see if there was a safer alternative. The first large study showed that patients did better with the ...
Bicuspid aortic valves (BAVs) represent a wide morphologic and functional spectrum. In coarctation of the aorta, BAVs are common, but the proportion of BAV subtypes and their relation to aortic dimensions and development of late valve dysfunction are unknown. Sixty-two cardiovascular magnetic resonance investigations of patients with coarctation of the aorta were reviewed with respect to aortic valve morphology, aortic valve function, and aortic dimensions. BAVs were identified in 45 patients (72.6 %), of which 13 (20.9 %) were type-0 (two commissures), 28 (45.1 %) type-1 (three commissures but fusion of one commissure with a raphe) and 4 (6.5 %) valves were bicuspid but not possible to classify further. Patients with BAVs type-0 had larger dimensions in their sinus of Valsalva (35.5 ± 6.8 vs. 29.7 ± 2.7 mm, p = 0.002), ascending aorta (33.1 ± 6.2 vs. 26.0 ± 4.3 mm, p = 0.005) and sino-tubular junction (29.3 ± 7.4 vs. 24.2 ± 3.5 mm, p = 0.040) compared with tricuspid aortic valves (TAVs). ...
Bicuspid aortic valve (BAV) refers to a spectrum of deformed aortic valves with two functional leaflets or cusps which are often unequal in size. They are most often congenital while an acquired bicuspid valve occurs when there is fibrous fusion...
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve in patients with severe, symptomatic aortic stenosis who are at low operative risk for standard aortic valve replacement (AVR). Prospective, randomized, controlled, multi-center trial. Patients having an operative mortality , 2% (low operative risk) for surgical aortic valve replacement will be randomized 1:1 to receive either transcatheter heart valve replacement (TAVR) with the Edwards SAPIEN 3 or aortic valve replacement with a commercially available surgical bioprosthetic valve. Patients will be seen for follow-up visits at discharge, 30 days, 6 months, and annually through 10 years.. If you would like additional information regarding this trial please visit the website below or contact [email protected] https://www.clinicaltrials.gov/ct2/show/NCT02675114. ...
Pouleur, Anne-Catherine ; Le Polain De Waroux, Jean-Benoît ; Pasquet, Agnes ; Watremez, Christine ; Vanoverschelde, Jean-Louis ; et. al. Successful repair of a quadricuspid aortic valve illustrated by transoesophageal echocardiography, 64-slice multidetector computed tomography, and cardiac magnetic resonance.. In: European Heart Journal (English Edition), Vol. 28, no. 22, p. 2769 (2007 ...
A person with mitral valve stenosis may need to take antibiotics before undergoing certain medical or dental procedures to prevent infective endocarditis (see page 192) in the valve. Medication to slow the heart rate may help some people feel better. In some people with moderate stenosis, a balloon valvuloplasty (a procedure to open the valve with a balloon; ) may be an option. For a person with a severely diseased valve, particularly an older person, surgical repair or replacement of the valve may be necessary.. Aortic Valve Disease. The aortic valve, which has three crescent-shaped cusps (lea?ets), regu- lates blood ?ow from the left ventricle into the aorta, where it then cir- culates to the rest of the body . Either stenosis (narrowing) or regurgitation (backward leakage) can disrupt the blood ?ow. The valve can be damaged by rheumatic fever or infection. But some people are born with a bicuspid aortic valve-a valve with two lea?ets instead of three. A bicuspid valve may be less ef?cient and ...
Manatee Memorial became the first facility on the West Coast of Florida to offer patients with aortic valve disease a new device for surgical aortic valve replacement.
This video will help you to understand the surgical procedure of aortic valve replacement. A full surgical procedure is shown here for your help.
A 73-year old man developed an acute prosthetic aortic valve dehiscence for which emergent operation was undertaken. The intraoperative evidence of an aortic annular disruption and of a subannular abscess led to the hypothesis that an endocarditis process was involved. The aortic valve was replaced with a stentless porcine bioprosthesis. Cultures taken intraoperatively from the aortic area had a pure growth of aerobic, spore-forming, gram-positive bacilli identified as Bacillus licheniformis. The patient responded to specific antibiotic therapy with no relapse at a 20-month follow-up. The potentiality of B. licheniformis as a pathogen should be reconsidered.. ...
AORTIC VALVE FUNCTION. The functional status of QAV is predominantly a pure AR[4,12], i.e., AR in QAV is more common than aortic stenosis[4], even though its primary incompetency may develop into subsequent stenosis at a later stage[1]. Tutarel & Westhoff-Bleck[13] reported that the functional status of QAV was regurgitant in 74.7%, combined stenosis and regurgitation in 8.4%, stenotic in 0.7%, and normally functioning in 16.2%. Yotsumoto et al.[14] reported that, among 616 patients for an aortic valve operation, 9 (1.46%) patients had a QAV, all of whom had significant AR except one with combined aortic stenosis and mild AR. They also found 55.6% (5/9) of the AR patients had a cusp fenestration. Janssens et al.[15] reported that AR was present in 56% (39/70) of the patients with a QAV. Tsang et al.[2] described that 23% of the patients with a QAV had progression of AR during a mean follow-up of 5.5±3.7 years, and an association between morphological characteristics of QAV and severity of AR ...
The bicuspid aortic valve is a known risk factor for the early and frequent occurrence of aortic valve defects, aneurysms and dissections. This study aims to develop an appropriate surgical therapy concept for patients with bicuspid aortic valve and dilatation of the ascending aorta. The data of 555 patients with bicuspid and 2015 patients with tricuspid aortic valve who underwent surgical treatment of the aortic valve and/or of the ascending aorta at our institution were evaluated. We analyzed the configuration of the ascending aorta by angiography, echocardiography and CT and described the aortic wall by histological and histomorphometric examination. We also analyzed the long-term results after reduction aortoplasty of the ascending aorta. Histological examination of the aortic wall specimens showed that patients with bicuspid aortic valve with increased diameter of the ascending aorta more often have histological signs of dilatation. More severe histological changes such as cystic media ...
What follows is a listing of factors that are active at different points of the proposed mechanisms of calcification. At present it is impossible to outline the most important ones.. Periostin is found in VICs from healthy bovine aortic valves, but expression increases following exposure to LPS. Periostin is chiefly expressed in VICs of the lamina ventricularis, less in the fibrosa, and is coexpressed with elastin.57 Periostin is secreted by macrophages and myofibroblasts, and it stimulates expression of MMP‐2 and ‐9 in human VICs. Wild‐type mice fed with the Western diet develop aortic stenosis, but periostin‐knockout mice do not. In addition, they express lower levels of αSMA, collagen 1, and MMP‐2 and ‐13.57 Periostin may thus play a stimulatory role in the development of valve calcification.. Jian and colleagues showed that whereas healthy aortic valves did not express MMP‐2 or ALP, diseased valves expressed both, as well as tenascin‐C, an extracellular matrix glycoprotein ...
Mean follow-up was 3.1 ± 2.6 years, with 440 AVRs and 194 deaths. High AVC density was associated with increased aortic valve peak velocity, higher mean gradient, and decreased valve area (p < 0.001 for each). Severe versus nonsevere AVC was associated with reduced 5-year survival in those treated medically (41 ± 6% vs. 78 ± 6%, p < 0.001). On multivariate analysis, severe AVC (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.04-2.92; p = 0.03) and severe AVC density (HR, 2.44; 95% CI, 1.37-4.37; p = 0.002) were independently associated with increased mortality in patients treated medically. For survival regardless of AVR, both severe AVC (HR, 1.71; 95% CI, 1.12-2.62; p = 0.01) and severe AVC density (HR, 2.22; 95% CI, 1.37-4.37; p = 0.002) remained associated with increased mortality; both of these variables remained statistically significant when adjusted for coronary artery calcium score in the subset with this available (p < 0.05 for each). Multivariable analysis observed that ...
In individuals with normal aortic valves, the valve area is 3.0 to 4.0 cm2. As aortic stenosis develops, minimal valve gradient is present until the orifice area becomes less than half of normal. The pressure gradient across a stenotic valve is direc
Unlike second-generation TAVI systems on the market today, the Trinity aortic valve is designed to be positioned precisely or even repositioned, even after full implantation, in a safe and simple manner," says principal investigator Christian Hengstenberg, a cardiologist at the German Heart Center, Munich, Germany, with no financial interest or arrangement or affiliation with Transcatheter Technologies. "In our study, Trinitys novel sealing cuff continues to provide outstanding follow-up results without paravalvular leak, an all-too-frequent complication of TAVI. Equally important, the Trinity aortic valve is designed to reduce the risk of atrio-ventricular block significantly through supra-annular positioning of the Trinity valve.". ...
In this study, we aimed to review the incidence of any type of AR after TAVI with the Edwards-Sapien valve and examine its effects on LV structure and function. This was accomplished by evaluating the trial-mandated transthoracic echocardiograms at a core laboratory. In addition, we sought specific anatomic features of the native valve and aortic root that would be associated with more severe AR.. We found that AR after deployment of the Edwards-Sapien valve occurs frequently; 75% of patients had some form of AR, detected by TTE, within 24 h of implantation. However, typically, the AR was of trace or mild severity. Trace central AR is a physiological finding for this bioprosthesis. Detection of paravalvular AR was more common than central AR regardless of the method of implantation or the size of the valve. Although the fully expanded valve-in-stent is round, the aortic annulus, in particular, a heavily calcified one, is not a perfect circle and the presence of paravalvular AR immediately after ...
Women undergoing transcatheter aortic valve replacement (TAVR) have better survival rates than men at one year, according to a study published in Annals of Internal Medicine. These results are the opposite of those seen in surgical aortic valve replacement (SAVR), for which female sex has been shown to be associated with poorer outcomes.
Initially, homograft aortic valves were implanted shortly after collection.7 This impractical method was rapidly supplanted by techniques to sterilize and preserve the valve for later use. Early methods employed beta-propiolactone6,8 or 0.02% chlorhexidine,9 followed by ethylene oxide or radiation exposure.10 Some were preserved by freeze-drying.6,10 Recognizing that the incidence of valve rupture was high in chemically treated valves, Barratt-Boyes introduced antibiotic sterilization of homografts in 1968.11 Cryopreservation of allografts was introduced in 1975 by OBrien and continues to be the predominant method.12,13 Experimental use of autologous valve transplantation began in 1961 when Lower and colleagues at Stanford transposed the autologous pulmonic valve to the mitral position in dogs14 and shortly thereafter to the aortic position.13 Donald Ross applied this to humans, reporting in 1967 clinical experience replacing either the aortic or the mitral valve with a pulmonary autograft.14 ...
Online Doctor Chat - Bicuspid aortic valve,palpitations, Ask a Doctor about Aortic valve, Online doctor patient chat conversation by Dr. Jyoti Patil
Results of the PARTNER II SAPIEN 3 Trial Presented at TCT 2015. SAN FRANCISCO - October 15, 2015 - One-year patient outcomes from the PARTNER II trial showed that the low rate of 30-day complications with balloon-expandable transcatheter aortic valve replacement (TAVR) in high-risk and inoperable patients with aortic stenosis persisted with follow up to one year.. One-year findings from the PARTNER II SAPIEN 3 study were presented today at the 27th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the worlds premier educational meeting specializing in interventional cardiovascular medicine.. The initial PARTNER I trial demonstrated the early promise of TAVR with first generation devices for high-risk (HR) and inoperable (INOP) patients. The PARTNER II SAPIEN 3 trial was a two single arm, non-randomized, historical-controlled study that utilizes the newest generation balloon-expandable TAVR device. ...
OBJECTIVES: Describe changes in measures of right ventricular (RV) function in patients treated for aortic stenosis using open-chest surgery (SAVR) or transcatheter treatment (TAVR).. METHODS: Patients in the Nordic Aortic Valve Intervention (NOTION) trial were randomized 1:1 to TAVR (n = 114) or SAVR (n = 106). Echocardiography was performed at baseline and 3 and 12 months post-procedure. Tricuspid annular plane systolic excursion (TAPSE) and right ventricular fractional area change (RVFAC) were used as measures of longitudinal and transverse RV contraction. Left ventricular ejection fraction (LVEF) and LV atrioventricular plane displacement (AVPD) were recorded as measures of LV function. Association to NYHA class was examined.. RESULTS: There were no differences in echocardiographic measurements between TAVR and SAVR at baseline. In the SAVR group, TAPSE was reduced after 3 months (2.4 ± 0.5 cm vs 1.6 ± 0.4 cm; P , 0.001), and 12 months (2.4 ± 0.5 cm vs 1.7 ± 0.4 cm; P , 0.001). RVFAC was ...
The Aortic valve is located at the outlet of the Aorta and delimits the Aorta from the left ventricle.. The Aortic valve enables passage of blood through it into the Aorta during systole, the phase of contraction of the left ventricle.. During diastole, when the ventricle is relaxed and the pressure in it decreases, there is risk of reverse blood flow from the Aorta (because the pressure therein is higher) into the left ventricle. The Aortic valve is here to prevent such back flow.. In instances when the valve is damaged or does not close properly, leakage into the left ventricle (regurgitation) can occur. Such leak reduces the amount of blood pumped into the Aorta on the one hand and constitutes an additional load for the left ventricle on the other hand .. ...
Subclinical leaflet thrombosis occurred frequently in bioprosthetic aortic valves, more commonly in transcatheter than in surgical valves. Anticoagulation (both NOACs and warfarin), but not dual antiplatelet therapy, was effective in prevention or treatment of subclinical leaflet thrombosis. Subclinical leaflet thrombosis was associated with increased rates of TIAs and strokes or TIAs. Despite excellent outcomes after TAVR with the new-generation valves, prevention and treatment of subclinical leaflet thrombosis might offer a potential opportunity for further improvement in valve haemodynamics and clinical outcomes.. ...
A method of implanting a prosthetic valve in a stenosed aortic valve via a catheterization technique. A balloon catheter is advanced into a patients vasculature and a balloon is expanded within the stenosed aortic valve to push aside the calcified leaflets. The prosthetic valve is then introduced into a patients vasculature through an 18 French arterial introducer. After advancement through the femoral artery and aorta, the prosthetic valve is radially expanded for implantation in the dilated aortic valve. The prosthetic valve includes a compressible and expandable frame and a valvular structure made with pericardial tissue. The prosthetic valve further includes an internal cover fastened to an internal surface of the frame between an inlet end of the frame and the valvular structure.
Aortic valve replacement (AVR) has been the mainstay of treatment of symptomatic severe aortic stenosis (AS). The role of transcatheter aortic valve implantation (TAVI; also known as transcatheter aortic valve replacement or TAVR) as an alternative t
Looking for online definition of Carpentier-Edwards aortic valve prosthesis in the Medical Dictionary? Carpentier-Edwards aortic valve prosthesis explanation free. What is Carpentier-Edwards aortic valve prosthesis? Meaning of Carpentier-Edwards aortic valve prosthesis medical term. What does Carpentier-Edwards aortic valve prosthesis mean?
According to the latest market report published by Persistence Market Research titled Global Transcatheter Heart Valve Replacement & Repair Market: Global Industry Analysis and Forecast, 2016 - 2026, the global transcatheter heart valve replacement & repair market is projected to expand at a CAGR of 13.9% during the forecast period (2016-2026).. Request for Report [email protected]://www.persistencemarketresearch.com/samples/11167. Transcatheter heart valve replacement is a relatively non-invasive procedure to repair the damaged heart valves with bioprosthetic valves for treatment of valvular heart disease namely aortic stenosis and mitral regurgitation among geriatric population. It is an alternative approach to conventional open heart surgery, especially for extremely high risk patients. Transcatheter heart valve replacement & repair market was valued at US$ 1,605.5 Mn in 2015 and the revenue is expected to increase to US$ 6,701.5 Mn by 2026 at a CAGR of 13.9% over the forecast period.. The report ...
The Edwards SAPIEN 3 Transcatheter Heart Valve System and Edwards SAPIEN 3 Ultra Transcatheter Heart Valve System are indicated for relief of aortic stenosis in patients with symptomatic heart disease due to severe native calcific aortic stenosis who are judged by a Heart Team, including a cardiac surgeon, to be appropriate for the transcatheter heart valve replacement therapy.. The Edwards SAPIEN 3 Transcatheter Heart Valve System and Edwards SAPIEN 3 Ultra Transcatheter Heart Valve System are indicated for patients with symptomatic heart disease due to failure (stenosed, insufficient, or combined) of a surgical bioprosthetic aortic or mitral valve who are judged by a heart team, including a cardiac surgeon, to be at high or greater risk for open surgical therapy (i.e., predicted risk of surgical mortality ≥ 8% at 30 days, based on the STS risk score and other clinical co-morbidities unmeasured by the STS risk calculator).. Contraindications (Who should not use): ...
Treatment of Pulmonary valve stenosis is a narrowing of the pulmonary valve, the flap that separates the lower right chamber (right ventricle) of your heart from the pulmonary artery. During circulation, oxygen-poor blood returning from your body is pumped from your heart, through the pulmonary valve and into the pulmonary artery, which carries the blood to your lungs to pick up oxygen and drop off carbon dioxide. If the pulmonary valve is constricted (stenosed), your heart has to pump harder to push blood through the valve and into the pulmonary artery, The disorder is usually present since birth (congenital). Its one of the more common heart birth defects, with the majority of the cases being mild. Pulmonary valve stenosis occurs in about one of 10 children, and females are slightly more likely to be affected than males. Adults occasionally have pulmonary valve stenosis as a complication of another illness, Pulmonary valve stenosis ranges from mild and without symptoms to severe and debilitating.
We successfully performed coronary artery bypass grafting and mitral valve replacement in a 72-year-old man who had undergone a left pneumonectomy 13 years previously due to a malignant mass. The patient was admitted to our clinic with symptoms of dyspnoea, palpitations, chest pain and fatigue. He was diagnosed with mitral valve disease and two-vessel coronary artery disease, as seen from echocardiography and catheterisation studies. Conventional cardiopulmonary bypass grafting was performed following sternotomy. The patient's heart was completely displaced to the left hemithorax. Saphenous vein grafts were harvested. Distal anastomoses were performed with the use of the on-pump beating heart technique without cross clamping. Afterwards a cross clamping was placed and a left atriotomy was performed. The mitral valve was severely calcific. A mitral valve replacement was performed using number 27 mechanical valve after the valve had been excised. The patient's postoperative course was uneventful
Your blood is supposed to follow a one-way path through your heart. It flows in through the top chamber (the left atrium), down to the bottom chamber (the left ventricle), and then out to your body. Your mitral valve separates these two chambers and keeps the blood from flowing backward. In mitral valve regurgitation, your mitral valve does not work as it should and allows blood to flow backward into your upper heart chamber.. Mitral valve regurgitation can happen suddenly (acute) or, more commonly, gradually over time (chronic). Acute mitral valve regurgitation is often caused by damage to the heart, perhaps from a heart attack or a heart infection called endocarditis. There are many possible reasons you can develop chronic mitral valve regurgitation, including mitral valve prolapse, rheumatic heart disease and untreated high blood pressure. If you have mitral valve regurgitation, you may notice that you feel very tired and that you have a hard time catching your breath when you exercise or ...
TY - JOUR. T1 - Bioprosthetic mitral valve thrombosis complicating antiphospholipid antibody syndrome, successfully treated with thrombolysis. AU - Chamsi-Pasha, Mohammed A.. AU - Alyousef, Tareq. AU - Sayyed, Samer H. PY - 2014/1/1. Y1 - 2014/1/1. N2 - The incidence of bioprosthetic valve thrombosis and related embolic complications is extremely rare, obviating the need for long-term anticoagulation. As a result, experience in the diagnosis and treatment of bioprosthetic valve thrombosis is fairly limited. We report the first case of antiphospholipid antibody syndrome presenting as bioprosthetic mitral valve thrombosis, 15 months after valve replacement, and successfully treated with thrombolytic therapy. (Echocardiography 2014;31:E278-E281).. AB - The incidence of bioprosthetic valve thrombosis and related embolic complications is extremely rare, obviating the need for long-term anticoagulation. As a result, experience in the diagnosis and treatment of bioprosthetic valve thrombosis is fairly ...
TY - JOUR. T1 - Left atrial isolation for the treatment of atrial fibrillation due to mitral valve disease. Hemodynamic evaluation. AU - Graffigna, A.. AU - Ressia, L.. AU - Pagani, F.. AU - Minzioni, G.. AU - Vigano, M.. PY - 1993. Y1 - 1993. N2 - Ablation of atrial fibrillation secondary to mitral valve disease is frequently impossible after isolated mitral valve surgery. In order to improve sinus rhythm recovery in such patients, patients with rheumatic mitral valve disease and chronic atrial fibrillation underwent surgical electrophysiological isolation of the left atrium at the time of surgery. The left atrium is left free to fibrillate, beat or stand still, while the right atrium recovers its sinus activation and warrants a regular ventricular rate. Apart from this advantage, we tested the hypothesis that the recovery of right atrial booster function could significantly improve cardiac output. From May 1989 to July 1993 184 patients with mitral with or without other valve disease ...

Sparing the Aortic ValveSparing the Aortic Valve

... dissects down the aorta to the aortic valve and removes the aneurysmal aortic wall; he then re-suspends the native valve within ... "If you had surgery for transposition as a baby and now youre a 22-year-old with an aortic root aneurysm with aortic valve ... in which he replaces the aortic root and then reimplants the patients existing valve, reducing the need for valve replacement ... In valve sparing aortic root replacement, Vricella excises the aorta at the sinotubular junction, ...
more infohttps://www.hopkinsmedicine.org/news/articles/sparing-the-aortic-valve

Bicuspid Aortic Valve: Care InstructionsBicuspid Aortic Valve: Care Instructions

... like aortic valve stenosis and aortic valve regurgitation, more likely.. In aortic valve stenosis, the valve has narrowed. Your ... One of these valves, the aortic valve, usually has three flaps, or leaflets. But sometimes people are born with an aortic valve ... In aortic valve regurgitation, the valve does not close properly. Some of the blood leaks back (regurgitates) through the valve ... This is called a bicuspid aortic valve.. A bicuspid aortic valve makes certain heart problems, ...
more infohttps://myhealth.alberta.ca/health/AfterCareInformation/pages/conditions.aspx?hwid=ug5699

Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis<...Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis<...

title = "Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis",. abstract = "Leaflet immobility and valve ... Holmes, D., & Mack, M. J. (2017). Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis. Circulation, 135(18), ... Aortic Valve Bioprostheses : Leaflet Immobility and Valve Thrombosis. / Holmes, David; Mack, Michael J. ... Holmes, D & Mack, MJ 2017, Aortic Valve Bioprostheses: Leaflet Immobility and Valve Thrombosis, Circulation, vol. 135, no. 18 ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/aortic-valve-bioprostheses-leaflet-immobility-and-valve-thrombosi

Genetic bases of bicuspid aortic valve: The contribution of traditional and high-throughput sequencing approaches on research...Genetic bases of bicuspid aortic valve: The contribution of traditional and high-throughput sequencing approaches on research...

Bicuspid aortic valve (BAV) is a common (0.5-2.0% of general population) congenital heart defect with increased prevalence of ... Bicuspid aortic valve (BAV) is a common (0.5-2.0% of general population) congenital heart defect with increased prevalence of ... Recently, a role for GATA4/5 in aortic valve morphogenesis and endocardial cell differentiation has been reported. BAV has also ... Recently, a role for GATA4/5 in aortic valve morphogenesis and endocardial cell differentiation has been reported. BAV has also ...
more infohttps://flore.unifi.it/handle/2158/1104398

Aortic valve - WikipediaAortic valve - Wikipedia

Aortic valve repair[edit]. Main article: Aortic valve repair. Aortic valve repair or aortic valve reconstruction describes the ... Aortic valve replacement[edit]. Main article: Aortic valve replacement. Aortic valve replacement is a surgical procedure in ... The aortic valve can be affected by a range of diseases and require aortic valve replacement. The valve can become either leaky ... The aortic valve is a valve in the human heart between the left ventricle and the aorta. It is one of the two semilunar valves ...
more infohttps://en.wikipedia.org/wiki/Aortic_valve

Quadricuspid aortic valve - WikipediaQuadricuspid aortic valve - Wikipedia

... and aortic valve replacement, usually with a synthetic valve.[8] Incidence[edit]. Quadricuspid aortic valves are very rare ... Quadricuspid aortic valve. A quadricuspid aortic valve (QAV) is a rare congenital heart defect characterized by the presence of ... A short-axis ultrasound of the aortic valve allows for the best view of the aortic valve, and gives a clear indication of the ... a b Tutarel, O. (2004). The quadricuspid aortic valve: a comprehensive review. The Journal of Heart Valve Disease, 13(4), 534- ...
more infohttps://en.wikipedia.org/wiki/Quadricuspid_aortic_valve

Category:Aortic valve - Wikimedia CommonsCategory:Aortic valve - Wikimedia Commons

aortic valve valve in the human heart between the left ventricle and the aorta. ... Media in category "Aortic valve". The following 13 files are in this category, out of 13 total. ... C.J.B. Williams, 1840; aortic valves Wellcome L0006914.jpg 1,666 × 1,070; 734 KB. ... C.J.B. Williams; aortic valves Wellcome L0006912.jpg 1,274 × 1,552; 348 KB. ...
more infohttps://commons.wikimedia.org/wiki/Category:Aortic_valve

Aortic Valve Disease | HealthCentralAortic Valve Disease | HealthCentral

... the aortic valve, one of the four valves in the heart. Description The most common valvular problem in old age is aortic valve ... Definition Aortic Valve Disease entails damage to, and dysfunction of, ... Aortic Valve Disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. ... The aortic valve is one of four valves that control the flow of blood into and out of the heart. In particular, the aortic ...
more infohttps://www.healthcentral.com/encyclopedia/aortic-valve-disease

Aortic Valve Stenosis-Topic OverviewAortic Valve Stenosis-Topic Overview

... the aortic valve works like a one - way gate. When the heart pumps, the aortic valve opens to let oxygen - rich blood flow from ... Blood then flows through the aorta to the rest of the body.Aortic valve stenosis ... What is aortic valve stenosis?The heart has four chambers. In the lower left chamber (left ventricle), ... Aortic Valve Stenosis - Topic Overview. Articles OnAortic Valve Stenosis. Aortic Valve Stenosis Aortic Valve Stenosis * Topic ...
more infohttps://www.webmd.com/heart-disease/tc/aortic-valve-stenosis-overview

Aortic Valve Surgery | EmaxHealthAortic Valve Surgery | EmaxHealth

Aortic valve brought two famous people have been in the news recently. One just had aortic valve surgery and the other who will ... There are two types of replacement valves for the aortic valve - mechanical or biological. The advantage of a mechanical valve ... The most common cause of aortic valve disease requiring surgery is called "senile aortic calcification." The valve has worn out ... The aortic valve is a tricuspid valve. It helps control the outflow of blood from the left ventricle to the body. It opens to ...
more infohttps://www.emaxhealth.com/1024/80/29680/aortic-valve-surgery.html

Minimally-Invasive Aortic Valve ReplacementMinimally-Invasive Aortic Valve Replacement

What is the aortic valve?. The aortic valve is a one-way valve comprised of three leaflets that conducts blood flow from the ... What is aortic stenosis?. Aortic stenosis is a condition whereby the leaflets of the aortic valve become abnormally rigid such ... Diseases of the aortic valve are functionally classified into those that cause the valve to leak, known as aortic regurgitation ... How is the aortic valve replaced?. Aortic valve replacements require the use of cardiopulmonary bypass, otherwise known as ?the ...
more infohttps://www.hopkinsmedicine.org/heart_vascular_institute/conditions_treatments/treatments/minimally_invasive_aortic_valve_replacement.html

Aortic valve stenosis - Mayo ClinicAortic valve stenosis - Mayo Clinic

Typically the aortic valve has three cusps (tricuspid aortic valve), but some people are born with an aortic valve that has two ... Aortic valve stenosis is a defect that narrows or obstructs the aortic valve opening, making it difficult for the heart to pump ...
more infohttps://www.mayoclinic.org/normal-heart-and-aortic-valve-stenosis/img-20007788

Problem: Aortic Valve RegurgitationProblem: Aortic Valve Regurgitation

Aortic regurgitation describes the leakage of the aortic valve each time the left ventricle relaxes. Learn about ongoing care ... What is aortic valve regurgitation?. Aortic regurgitation is leakage of the aortic valve each time the left ventricle relaxes. ... What causes aortic regurgitation?. Common causes of severe aortic regurgitation are weakening of the valve tissue due to aging ... A leaking (or regurgitant) aortic valve allows blood to flow in two directions. Oxygen-rich blood either flows out through the ...
more infohttps://www.heart.org/HEARTORG/Conditions/More/HeartValveProblemsandDisease/Problem-Aortic-Valve-Regurgitation_UCM_450611_Article.jsp

Transcatheter Aortic Valve Implantation | SpringerLinkTranscatheter Aortic Valve Implantation | SpringerLink

The first-in-human transcatheter aortic valve implantation (TAVI) was successfully performed in 2002. In excess of 50,000 TAVI ... Transcatheter aortic valve implantation for severe aortic regurgitation in a stentless bioprosthetic valve with the core valve ... Conradi L, Seiffert M, Treede H et al (2011) Transcatheter aortic valve implantation versus surgical aortic valve replacement: ... Litzler PY, Cribier A, Zajarias A et al (2008) Surgical aortic valve replacement after percutaneous aortic valve implantation: ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4614-6144-9_10

Transcatheter aortic valve implantation: Periprocedural managementTranscatheter aortic valve implantation: Periprocedural management

The role of transcatheter aortic valve implantation (TAVI; also known as transcatheter aortic valve replacement or TAVR) as an ... has been the mainstay of treatment of symptomatic severe aortic stenosis (AS). ... Indications for aortic valve replacement, surgical aortic valve replacement, estimating the risk of aortic valve surgery, ... The role of transcatheter aortic valve implantation (TAVI; also known as transcatheter aortic valve replacement or TAVR) as an ...
more infohttps://www.uptodate.com/contents/transcatheter-aortic-valve-implantation-periprocedural-management

Aortic valve area in aortic stenosisAortic valve area in aortic stenosis

... the valve area is 3.0 to 4.0 cm2. As aortic stenosis develops, minimal valve gradient is present until the orifice area becomes ... The pressure gradient across a stenotic valve is direc ... Gorlin equation for aortic valve area. *Aortic valve resistance ... In individuals with normal aortic valves, the valve area is 3.0 to 4.0 cm2. As aortic stenosis develops, minimal valve gradient ... Doppler derived aortic valve resistance in aortic stenosis: its hemodynamic validation. J Heart Valve Dis 1994; 3:283. ...
more infohttp://www.uptodate.com/contents/aortic-valve-area-in-aortic-stenosis

Aortic Valve - Anatomy Pictures and InformationAortic Valve - Anatomy Pictures and Information

The aortic valve, or aortic semilunar valve, has three leaflets or cusps. It is located at the base of the aorta. It opens to ... When the ventricular muscles relax, the valve closes to prevent blood from backing up into the ventricular chamber. ...
more infohttps://www.innerbody.com/image_card02/card51-new.html

aortic valve replacementaortic valve replacement

Video Tag: Aortic Valve Replacement. SAGES Webinar : Preparing for the ABSITE-December 2016. ... aortic valve replacement, apex, appendiceal carcinoid tumor, appendiceal mass, appendix, ascending colon, ascites, autoimmune, ...
more infohttps://www.sages.org/video-tag/aortic-valve-replacement/

Bicuspid aortic valve - Pediatric Heart - MedHelpBicuspid aortic valve - Pediatric Heart - MedHelp

Hello I have a son who was born with a bicuspid aortic valve with moderate aortic stenosis which he got from his father. I have ... Hello I have a son who was born with a bicuspid aortic valve with moderate aortic stenosis which he got from his father. I have ... BAV can be associated with aortic valve stenosis, insufficiency, and prolapse, as well as aortic root dilation. In regards to ... Aortic valve stenosis intervention, which can accompany BAV, is a different story. As you may be aware, there are some centers ...
more infohttp://www.medhelp.org/posts/Pediatric-Heart/Bicuspid-aortic-valve/show/969796

aortic valve insufficiency - Pediatric Heart - MedHelpaortic valve insufficiency - Pediatric Heart - MedHelp

The cardiologist says his valve is leaking in 2 places and is a grade 2-3 leak. What activity restrictions should he have for ... My son was recently diagonsed with aortic valve insufficiency. ... in which his aortic valve is removed, his pulmonary valve is ... Aortic valve insufficiency (or regurgitation) is another term for a leak in the aortic valve, the valve between the left ... aortic valve insufficiency linda1986 My son was recently diagonsed with aortic valve insufficiency. The cardiologist says his ...
more infohttps://www.medhelp.org/posts/Pediatric-Heart/aortic-valve-insufficiency/show/945186

The Bicuspid Aortic Valve | CirculationThe Bicuspid Aortic Valve | Circulation

... bicuspid and tricuspid aortic valves by decade in adults having aortic valve replacement for isolated aortic stenosis. ... Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves. Am ... The association of bicuspid aortic valve with aortic aneurysm and dissection suggests the possibility that a bicuspid valve, at ... Clearly, an effective therapy to prevent calcific aortic valve stenosis-focusing on patients with a bicuspid aortic valve-would ...
more infohttp://circ.ahajournals.org/content/111/7/832

Aortic valve surgery - open: MedlinePlus Medical EncyclopediaAortic valve surgery - open: MedlinePlus Medical Encyclopedia

The aortic valve separates the heart and aorta. The aortic valve opens so blood can flow out. It then closes to keep blood ... Aortic valve replacement; Aortic valvuloplasty; Aortic valve repair; Replacement - aortic valve; AVR ... You may need aortic valve surgery to replace the aortic valve in your heart if: *Your aortic valve does not close all the way, ... The aortic valve separates the heart and aorta. The aortic valve opens so blood can flow out. It then closes to keep blood from ...
more infohttps://medlineplus.gov/ency/article/007408.htm

Transcatheter aortic valve replacement: MedlinePlus Medical EncyclopediaTranscatheter aortic valve replacement: MedlinePlus Medical Encyclopedia

... is a procedure used to replace the aortic valve without opening the chest. It is used to treat adults who arent healthy enough ... This is called aortic stenosis. If there is also a leak, it is called aortic regurgitation. Most aortic valves are replaced ... Transcatheter aortic valve replacement (TAVR) is a procedure used to replace the aortic valve without opening the chest. It is ... Blood flows out of your heart and into the aorta through a valve. This valve is called the aortic valve. It opens up so blood ...
more infohttps://medlineplus.gov/ency/article/007684.htm

Aortic Valve Stenosis: Symptoms, Causes, Diagnosis, TreatmentAortic Valve Stenosis: Symptoms, Causes, Diagnosis, Treatment

Aortic valve stenosis is a common and serious heart problem when the valve doesnt open fully. Learn about what causes it and ... Your aortic valve plays a key role in getting oxygen-rich blood to your body. ... "Aortic valve stenosis: Causes," "Aortic valve stenosis: Symptoms," "Aortic valve stenosis: Complications," "Aortic valve ... Causes of Aortic Valve Stenosis. Several conditions can cause your aortic valve to thicken. Among them are:. Calcium buildup: ...
more infohttps://www.webmd.com/heart-disease/aortic-valve-stenosis

aortic valve disease | Heartaortic valve disease | Heart

Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction Rafal ... Effect of thoracic epidural analgesia on clinical outcomes following transapical transcatheter aortic valve implantation ... Optimal pain management after aortic valve implantation: an opportunity to improve outcomes after transapical access in the ... Differences in performance of five types of aortic valve prostheses: haemodynamic assessment by dobutamine stress ...
more infohttps://heart.bmj.com/keyword/aortic-valve-disease
  • The Johns Hopkins Children's Center is well-positioned to treat these young patients at risk of aortic rupture, concludes Vricella, pointing to resources like the Broccoli Center for Aortic Diseases, the Johns Hopkins Comprehensive Marfan Center, and renowned faculty physicians, like geneticist Hal Dietz , who first identified the genes for Marfan and Loeys-Dietz syndromes. (hopkinsmedicine.org)
  • To get around these risks, Vricella offers young patients a valve-sparing approach, in which he replaces the aortic root and then reimplants the patient's existing valve, reducing the need for valve replacement down the road and long-term anticoagulation therapy. (hopkinsmedicine.org)
  • With the mechanical valve option, adds Vricella, patients have to be on life-long blood thinners, which increases their risk of stroke or bleeding. (hopkinsmedicine.org)
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