Pathological processes involving any part of the AORTA.
An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.
The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The main trunk of the systemic arteries.
Operative procedures for the treatment of vascular disorders.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The plan and delineation of prostheses in general or a specific prosthesis.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Substances used to allow enhanced visualization of tissues.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Elements of limited time intervals, contributing to particular results or situations.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.
The condition of an anatomical structure's being dilated beyond normal dimensions.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature.
The hollow, muscular organ that maintains the circulation of the blood.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Hospital unit providing continuous monitoring of the patient following anesthesia.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
The period of confinement of a patient to a hospital or other health facility.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
The valve between the left atrium and left ventricle of the heart.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
The planning of the furnishings and decorations of an architectural interior.
A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.

Endovascular stent graft repair of aortopulmonary fistula. (1/1622)

Two patients who had aortopulmonary fistula of postoperative origin with hemoptysis underwent successful repair by means of an endovascular stent graft procedure. One patient had undergone repeated thoracotomies two times, and the other one time to repair anastomotic aneurysms of the descending aorta after surgery for Takayasu's arteritis. A self-expanding stainless steel stent covered with a Dacron graft was inserted into the lesion through the external iliac or femoral artery. The patients recovered well, with no signs of infection or recurrent hemoptysis 8 months after the procedure. Endovascular stent grafting may be a therapeutic option for treating patients with aortopulmonary fistula.  (+info)

Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. (2/1622)

The class A scavenger receptors (SR-As) are trimeric, integral membrane glycoproteins that exhibit unusually broad ligand-binding properties. A number of studies have suggested that these receptors may play an important role in host defense and in many macrophage-associated pathological processes, including atherosclerosis and Alzheimer's disease. The study of the expression and function of these receptors in human disease has been hampered by the lack of suitable antibodies recognizing human SR-A. This has generated questions regarding the nature of receptors responsible for scavenger receptor activity detected in a variety of cell types, including monocytes, macrophages, smooth muscle cells, and endothelial cells. To address these questions, we have produced high-titer antisera recognizing human SR-A by using mice deficient for SR-A (SR-A -/-). We show that SR-A -/- mice produce a significantly higher-titer immune response than do wild-type (SR-A +/+) littermates, with antisera of the former having a broad species reactivity and recognizing SR-A from humans, mice, and rabbits. The antisera recognize both type I and II SR-A in a wide range of immunological techniques. Using these antisera we show that the expression of SR-A protein is induced during monocyte to macrophage differentiation and that SR-A mediates 80% of the uptake of acetylated low density lipoprotein by human monocyte-derived macrophages. We also establish that human SR-A is expressed by tissue macrophages in liver and lung and by macrophage-derived foam cells within aortic atherosclerotic lesions, with little detectable expression by smooth muscle cells or aortic endothelium.  (+info)

Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. (3/1622)

Recent data suggest that the immune system is involved in atherogenesis. Thus, interest has been raised as to the possible antigens that could serve as the initiators of the immune reaction. In the current work, we studied the effects of immunization with recombinant heat shock protein-65 (HSP-65) and HSP-65-rich Mycobacterium tuberculosis (MT) on early atherogenesis in C57BL/6J mice fed either a normal chow diet or a high-cholesterol diet (HCD). A rapid, cellular immune response to HSP-65 was evident in mice immunized with HSP-65 or with MT but not in the animals immunized with phosphate-buffered saline (PBS) alone. Early atherosclerosis was significantly enhanced in HCD-fed mice immunized with HSP-65 (n=10; mean aortic lesion size, 45 417+/-9258 microm2) or MT (n=15; 66 350+/-6850 microm2) compared with PBS-injected (n=10; 10 028+/-3599 microm2) or nonimmunized (n=10; 9500+/-2120 microm2) mice. No fatty streak lesions were observed in mice fed a chow diet regardless of the immunization protocol applied. Immunohistochemical analysis of atherosclerotic lesions from the HSP-65- and MT-immunized mice revealed infiltration of CD4 lymphocytes compared with the relatively lymphocyte-poor lesions in the PBS-treated or nonimmunized mice. Direct immunofluorescence analysis of lesions from HSP-65- and MT-immunized mice fed an HCD exhibited extensive deposits of immunoglobulins compared with the fatty streaks in the other study groups, consistent with the larger and more advanced lesions found in the former 2 groups. This model, which supports the involvement of HSP-65 in atherogenesis, furnishes a valuable tool to study the role of the immune system in atherogenesis.  (+info)

Atherosclerotic aortic gangliosides enhance integrin-mediated platelet adhesion to collagen. (4/1622)

Gangliosides, sialic acid-containing glycosphingolipids, accumulate in atherosclerotic vessels. Their role in the pathogenesis of atherosclerosis is unknown. Gangliosides isolated from tumor cells promote collagen-stimulated platelet aggregation and ATP secretion and enhance platelet adhesion to immobilized collagen. These activities are all mediated by ganglioside effects on the platelet integrin collagen receptor alpha2beta1. Therefore, we hypothesized that gangliosides isolated from atherosclerotic plaques would enhance platelet adhesion to immobilized collagen, a major component of the subendothelial matrix of blood vessels. Furthermore, we questioned whether this effect of atherosclerotic gangliosides might play a role in the pathogenesis of atherosclerosis. To test this hypothesis, we isolated the gangliosides from postmortem aortas of patients with extensive atherosclerotic disease and examined their effects on platelet adhesion. Samples of aortic tissue taken from areas involved with atherosclerotic plaque demonstrated accumulation of gangliosides (64.9+/-6.5 nmol/g wet weight) compared with gangliosides isolated from control normal aortic tissue taken from children who died of noncardiac causes (NAGs; 21.1+/-6.4 nmol/g wet weight). Interestingly, samples of tissue taken from diseased aortas but from areas not involved with gross plaque formation also demonstrated ganglioside accumulation (47.6+/-12.8 nmol/g wet weight). Next, the activity of each of these gangliosides on platelet adhesion to immobilized type I collagen was studied. Atherosclerotic aortic gangliosides (AAGs) as well as those isolated from grossly unaffected areas of the same aorta (UAGs) both increased platelet adhesion compared with control NAGs (OD570, 0. 37+/-0.11 and 0.29+/-0.14 versus 0.16+/-0.07, respectively; P<0.01 and P<0.05, respectively). These OD570 values corresponded to 9x10(5), 8x10(4), and 6x10(3) platelets per well after preincubation with 5 micromol/L AAG, UAG, and NAG, respectively. Increased adhesion was observed after preincubation with as little as 0.5 micromol/L AAG, and maximal adhesion was seen at 2.5 micromol/L, with a plateau extending to the highest concentration tested, 10 micromol/L. The effect of AAGs on platelet adhesion to collagen was abrogated by incubation of treated platelets with F-17 anti-alpha2 monoclonal antibody (OD570, 0.13+/-0.02). Finally, the effects of the major individual gangliosides isolated from atherosclerotic tissues, GM3 and GD3, were tested. GM3 increased adhesion to collagen (OD570, 0.415+/-0.06) as did GD3 (0.31+/-0.08). Similar to that of AAGs, the effect of both molecules was blocked by F-17 (0. 09+/-0.04 and 0.13+/-0.06, respectively). These experiments demonstrate that accumulated atherosclerotic gangliosides promote platelet adhesion to collagen, the major component of the subendothelial matrix. Furthermore, this activity is mediated by an effect of the gangliosides on the collagen-binding integrin alpha2beta1. This activity may provide a mechanism for the development of platelet thrombi at sites where atherosclerotic gangliosides accumulate and help to explain the role of platelets in the process of atherosclerotic disease progression.  (+info)

ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. (5/1622)

Along with apolipoprotein (apo) E, which promotes cholesterol efflux from foam cells, apoA1-containing high density lipoprotein (HDL) is thought to facilitate the transport of cholesterol from lesions. This role for apoA1 was tested in vivo by lethally irradiating apoE-deficient and apoE- plus apoA1-deficient mice and reconstituting them with bone marrow cells isolated from wild-type (WT) mice. ApoE, but not apoA1, was synthesized by the transplanted bone marrow-derived cells. Therefore, this transplantation procedure generated apoE-deficient animals with atherosclerotic lesions that contained both apoE and apoA1 (E/A1 mice) and apoE-deficient animals with lesions that contained apoE but no apoA1 (E/A1o mice). As shown previously, the transplanted WT macrophage-derived apoE dramatically lowered the plasma hypercholesterolemia in both groups. On feeding with an atherogenic diet after transplantation, plasma cholesterol levels were raised in both groups of mice, but the levels in the E/A1 mice at 20 weeks were 2- to 3-fold higher than in E/A1o mice. Immunohistochemical staining verified that apoE was abundant in lesions of both groups, whereas apoA1 was detected in the lesions of E/A1 mice only. Despite a 2- to 3-fold lower total plasma cholesterol in the E/A1o mice, the free cholesterol recovered from isolated aortas was approximately 60% higher and the mean lesion area in serial sections of the aortic valves 45% larger. Therefore, apoA1 reduces free cholesterol accumulation in vivo in atherosclerotic lesions.  (+info)

Generation and characterization of human smooth muscle cell lines derived from atherosclerotic plaque. (6/1622)

The study of atherogenesis in humans has been restricted by the limited availability and brief in vitro life span of plaque smooth muscle cells (SMCs). We describe plaque SMC lines with extended life spans generated by the expression of the human papillomavirus (HPV)-16 E6 and E7 genes, which has been shown to extend the life span of normal adult human aortic SMCs. Resulting cell lines (pdSMC1A and 2) demonstrated at least 10-fold increases in life span; pdSMC1A became immortal. The SMC identity of both pdSMC lines was confirmed by SM22 mRNA expression. pdSMC2 were generally diploid but with various structural and numerical alterations; pdSMC1A demonstrated several chromosomal abnormalities, most commonly -Y, +7, -13, anomalies previously reported in both primary pdSMCs and atherosclerotic tissue. Confluent pdSMC2 appeared grossly similar to HPV-16 E6/E7-expressing normal adult aortic SMCs (AASMCs), exhibiting typical SMC morphology/growth patterns; pdSMC1A displayed irregular cell shape/organization with numerous mitotic figures. Dedifferentiation to a synthetic/proliferative phenotype has been hypothesized as a critical step in atherogenesis, because rat neonatal SMCs and adult intimal SMCs exhibit similar gene expression patterns. To confirm that our pdSMC lines likewise express this apparent plaque phenotype, osteopontin, platelet-derived growth factor B, and elastin mRNA levels were determined in pdSMC1A, pdSMC2, and AASMCs. However, no significant increases in osteopontin or platelet-derived growth factor B expression levels were observed in either pdSMC compared with AASMCs. pdSMC2 alone expressed high levels of elastin mRNA. Lower levels of SM22 mRNA in pdSMC1A suggested greater dedifferentiation and/or additional population doublings in pdSMC1A relative to pdSMC2. Both pdSMC lines (particularly 1A) demonstrated high message levels for matrix Gla protein, previously reported to be highly expressed by human neointimal SMCs in vitro. These results describe 2 novel plaque cell lines exhibiting various features of plaque SMC biology; pdSMC2 may represent an earlier plaque SMC phenotype, whereas pdSMC1A may be representative of cells comprising an advanced atherosclerotic lesion.  (+info)

Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. (7/1622)

Inflammation is a major feature of human atherosclerosis and is central to development and progression of the disease. A variety of proinflammatory cytokines are expressed in the atherosclerotic plaque and may modulate extracellular matrix remodeling, cell proliferation, and cell death. Little is known, however, about the expression and potential role of anti-inflammatory cytokines in human atherosclerosis. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine whose expression and potential effects in advanced human atherosclerotic plaques have not been evaluated. We studied 21 advanced human atherosclerotic plaques. IL-10 expression was analyzed by use of reverse transcription-polymerase chain reaction and immunohistochemical techniques. Inducible nitric oxide synthase expression was assessed by using immunohistochemistry, and cell death was determined by use of the TUNEL method. Reverse transcription-polymerase chain reaction identified IL-10 mRNA in 12 of 17 atherosclerotic plaques. Immunohistochemical staining of serial sections and double staining identified immunoreactive IL-10 mainly in macrophages, as well as in smooth muscle cells. Consistent with its anti-inflammatory properties, high levels of IL-10 expression were associated with significant decrease in inducible nitric oxide synthase expression (P<0.0001) and cell death (P<0. 0001). Hence, IL-10, a potent anti-inflammatory cytokine, is expressed in a substantial number of advanced human atherosclerotic plaques and might contribute to the modulation of the local inflammatory response and protect from excessive cell death in the plaque.  (+info)

Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. (8/1622)

BACKGROUND: Secoisolariciresinol diglucoside (SDG) is a plant lignan isolated from flaxseed. Lignans are platelet-activating factor-receptor antagonists that would inhibit the production of oxygen radicals by polymorphonuclear leukocytes. SDG is an antioxidant. Antioxidants studied thus far are known to reduce hypercholesterolemic atherosclerosis. The objective of this study was to determine the effect of SDG on various blood lipid and aortic tissue oxidative stress parameters and on the development of atherosclerosis in rabbits fed a high-cholesterol diet. METHODS AND RESULTS: Rabbits were assigned to 4 groups: group 1, control; group 2, SDG control (15 mg. kg body wt-1. d-1 PO); group 3, 1% cholesterol diet; and group 4, same as group 3 but with added SDG (15 mg. kg body wt-1. d-1 PO). Blood samples were collected before (time 0) and after 4 and 8 weeks of experimental diets for measurement of serum triglycerides, total cholesterol (TC), and LDL, HDL, and VLDL cholesterol (LDL-C, HDL-C, and VLDL-C). The aorta was removed at the end of the protocol for assessment of atherosclerotic plaques; malondialdehyde, an aortic tissue lipid peroxidation product; and aortic tissue chemiluminescence, a marker for antioxidant reserve. Serum TC, LDL-C, and the ratios LDL-C/HDL-C and TC/HDL-C increased in groups 3 and 4 compared with time 0, the increase being smaller in group 4 than in group 3. Serum HDL-C decreased in group 3 and increased in group 4 compared with time 0, but changes were lower in group 3 than in group 4. SDG reduced TC and LDL-C by 33% and 35%, respectively, at week 8 but increased HDL-C significantly, by>140%, as early as week 4. It also decreased TC/LDL-C and LDL-C/HDL-C ratios by approximately 64%. There was an increase in aortic malondialdehyde and chemiluminescence in group 3, and they were lower in group 4 than in group 3. SDG reduced hypercholesterolemic atherosclerosis by 73%. CONCLUSIONS: These results suggest that SDG reduced hypercholesterolemic atherosclerosis and that this effect was associated with a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve.  (+info)

Aims Intra-operative grading of atheromatous plaques in the ascending aorta by epiaortic ultrasound (EAU) and transesophageal echocardiography (TEE) in patients who have undergone CABG. Methods and results Sixty patients scheduled for elective CABG were prospectively enrolled to undergo intra-operative TEE and EAU ultrasound scanning of the ascending aorta. The ascending aorta was divided into three sections; proximal, middle and distal, and four segments; anterior, posterior, medial and lateral. Degree of atherosclerosis was graded according to a modified Montgomery scale. Epiaortic ultrasound was unable to provide images for a reliable assessment in 56 areas (7.7%; 56/720) vs 322 non-visualized areas by TEE (44.7%; 298/720) (p , 0.01). Out of 563 areas that scored ≥ 2, EAU visualized 379/720 areas (52.6%), whereas TEE visualized 184/720 areas (25.5%) (p , 0.01). EAU mean scores were significantly higher for the mid (p = 0.0001) and distal (p = 0.05) sections and for the posterior segment (p ...
In his presentation entitled Acute Aortic Syndromes: New Insights from IRAD and GenTAC Registries, Dr. Eagle will review the latest in the approaches to diagnosis and treatment of acute aortic syndromes and thoracic aortic disease. In particular, new insights as to the underlying causes of aortic syndromes, the optimal use of biomarkers, and the evolving role of genetics as it relates to diagnosis and screening will be emphasized. In addition, recent advances in best medical and interventional therapy for thoracic aortic disease will be discussed. Finally, Dr. Eagle will discuss where translational and imaging research advances are likely to shape the future care for patients with or at risk for thoracic aortic disease. ...
TY - JOUR. T1 - Acute aortic syndromes. T2 - A second look at dual-phase CT. AU - Lovy, Andrew J.. AU - Rosenblum, Jessica K.. AU - Levsky, Jeffrey M.. AU - Godelman, Alla. AU - Zalta, Amin B.. AU - Jain, Vineet R.. AU - Haramati, Linda B.. PY - 2013/4. Y1 - 2013/4. N2 - OBJECTIVE. The purpose of this article is to assess the diagnostic performance of the unenhanced and contrast-enhanced phases separately in patients imaged with CT for suspected acute aortic syndromes. MATERIALS AND METHODS. All adults (n = 2868) presenting to our emergency department from January 1, 2006, through August 1, 2010, who underwent unenhanced and contrast-enhanced CT of the chest and abdomen for suspected acute aortic syndrome were retrospectively identified. Forty-five patients with acute aortic syndrome and 45 healthy control subjects comprised the study population (55 women; mean age, 61 ± 16 years). Unenhanced followed by contrast-enhanced CT angiography (CTA) images were reviewed. Contrastenhanced CTA ...
Looking for Aortic diseases? Find out information about Aortic diseases. primary artery of the circulatory system circulatory system, group of organs that transport blood and the substances it carries to and from all parts of the... Explanation of Aortic diseases
Acute aortic syndrome (AAS) describes a range of severe, painful, potentially life-threatening abnormalities of the aorta. These include aortic dissection, intramural thrombus, and penetrating atherosclerotic aortic ulcer. AAS can be caused by a lesion on the wall of the aorta that involves the tunica media, often in the descending aorta. It is possible for AAS to lead to acute coronary syndrome. The term was introduced in 2001. Causes can include aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer or a thoracic aneurysm that has become unstable. The potential causes of AAS are life-threatening and present with similar symptoms, making it difficult to distinguish the ultimate cause, though high resolution, high contrast computerised tomography can be used. The condition can be mimicked by a ruptured cyst of the pericardium, ruptured aortic aneurysm and acute coronary syndrome. Misdiagnosis is estimated at 39% and is associated with delays correct diagnosis and improper ...
eview article describes the imaging modalities contributing to the diagnosis of aortic atherosclerosis. All imaging modalities do contribute to diagnostic imaging; however only echo provides realtime imaging during the different phases of treatment. If conventional TEE imaging quality is insufficient, additional screening with modified TEE or epiaortic ultrasound is advised. Modified TEE with A-View has the advantage to be performed before surigcal incision, when changes in surgical management or a crossover to a nonsurgical management can still be considered.. Click on the picture to read the article.. ...
The SPARC study is the only large-scale, population-based TEE study performed to date. Study participants were sampled from the adult population residing in a well-defined geographic area, are relatively free of selection bias, and are representative of the general population.. The following study limitations should be noted. First, this was a cross-sectional study, one lacking prospective follow-up data. However, data relating aortic plaque morphology, C pneumoniaeserology, and inflammatory markers to future cardiovascular and cerebrovascular events will be available during long-term follow up of the study cohort.. Second, we examined the association between C pneumoniaeIgG antibody titers and aortic atherosclerosis, assuming that the presence of IgG titers beyond a certain threshold (i.e., titers ≥1:16) is indicative of chronic C pneumoniaeinfection (7). Moreover, we examined the association between various levels of antibody titers and aortic atherosclerosis (4,7)and excluded one subject ...
Topic: Stress management for patients with an Aortic Disease. Location: East Foustanellas Conference Rm (H2368), second floor. Details: Group sessions will take place on the 3rd Tuesday of every other month. Patients with a history of an aortic aneurysm, aortic surgery or aortic dissection and their family are welcome to attend.
Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The most common problem is an aortic aneurysm, a bulging out of the artery wall that stretches like a balloon under the pressure of bloo
Causes and diagnosis of medical symptom Abdominal aortic atherosclerosis with references to diagnosis, testing, and other symptoms.
BACKGROUND:Since aortic calcification has been shown to initiate in the lower zone of well-thickened plaques (LZP) adjacent to the aortic media of rabbits fed supplemental cholesterol diets, a restricted supply of serum ...
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the thickness of a garden hose and runs from your heart through your chest and abdomen, carryin
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the
Genetics. With facilities throughout Orange County, The Hoag Health Network offers diverse health care to patients in the area. Learn more!
The authors concluded that endovascular technology could be helpful in treating selected young patients with genetically triggered thoracic aortic disease. However, we should be caution evaluating results of this mid-term follow-up study. Most aortic surgeons support the idea of endovascular therapy of genetically triggered aortic disease, but only in case of already prosthetic replaced aortic segments corresponding to proximal and distal landing zones. Endovascular treatment of the native aorta in Marfan and Loeys-Dietz syndrome patients is not recommended due to high-risk of later endoleaks type I. Further research and long-term follow-up studies are necessary to identify patients with genetically triggered thoracic aortic disease who benefit from endovascular aortic repair and delineate contraindication for endovascular approach.. ...
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Penetrating Atherosclerotic Ulcer
Our experience suggest that nonsurgical repair may be an effective therapeutic option for patients with descending thoracic aortic diseases such as aneurysms, pseudoaneurysms, or dissections.. Aneurysm of descending thoracic aorta was the first thoracic aortic disease to be repaired by a stent graft endovascular procedure. Effectively thoracic aneurysm stent graft treatment has the longest and most established long term results.4-6 In the past, our management of descending thoracic aortic aneurysm was medical unless clinical and instrumental signs of rupture were evident and required immediate surgery. At the present time, indications for stent graft treatment are presence of an uncomplicated aneurysm and history of hypertension with chest discomfort, or signs of compression on surrounding organs, as well as a diameter ,6 cm or expansion ,5 mm per year. However, if a patient is considered to be a candidate for stent graft placement, several major factors have to be taken into account. The most ...
TY - JOUR. T1 - International Heterogeneity in Diagnostic Frequency and Clinical Outcomes of Ascending Aortic Intramural Hematoma. AU - Pelzel, Jamie M.. AU - Braverman, Alan C.. AU - Hirsch, Alan T.. AU - Harris, Kevin M.. PY - 2007/11/1. Y1 - 2007/11/1. N2 - Background: Differing diagnostic frequencies and management strategies for intramural hematoma (IMH) have been described in North American (NA)/European and Japanese/Korean studies. Methods: All publications including type-A aortic IMH were reviewed for details on patient demographics, treatment strategy, and clinical outcomes. Publications were stratified by the geographic region (NA/Europe or Japan/Korea). Results: IMH, as a percentage of aortic dissection, occurs more frequently in Japan/Korea versus NA/Europe (31.7% vs 10.9%, P , .0001). The proportion of patients treated with early medical therapy is greater in Japanese/Korean studies (77.9% vs 48.8% in NA/Europe, P , .0001). However, the overall mortality is significantly lower in ...
To present the early and midterm results of endovascular stent-graft repair in patients with infrarenal penetrating aortic ulcers (PAU). Between January 1997 and December 2009, 20 patients (17 men; median age 72 years, range 48-85) with PAU of
Endovascular stent grafting has been recently considered as a less invasive alternative to either medical therapy or open surgical treatment for many patients with descending thoracic aortic disease. Late complications are rarely described in literature. Herein, we described the occurrence of an aorto-bronchial fistula and a retro-A dissection in a 73-year-old man after stent-grafting for a penetrating atherosclerotic ulcer (PAU) of the descending thoracic aorta and the successful surgical technique adopted in order to remove the stent-graft.
TY - JOUR. T1 - Different infarction patterns in patients with aortic atheroma compared to those with cardioembolism or large artery atherosclerosis. AU - Kim, Seung Woo. AU - Kim, Young Dae. AU - Chang, Hyuk Jae. AU - Hong, Geu Ru. AU - Shim, Chi Young. AU - Chung, Seok Jong. AU - Hong, Jin Yong. AU - Song, Tae Jin. AU - Song, Dongbeom. AU - Bang, Oh Young. AU - Heo, Ji Hoe. AU - Nam, Hyo Suk. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Aortic atheroma is a known cause of ischemic stroke. However, it is unclear whether ischemic stroke is caused by emboli from aortic atheroma or by accompanying atherosclerosis. In this study, we evaluated lesion patterns of patients with complex aortic plaque (CAP) to assume the underlying pathophysiology. Acute ischemic stroke patients who underwent transesophageal echocardiography were included. CAP was defined as a plaque in the proximal aorta ≥ 4 mm thick or with a mobile component. The diffusion-weighted imaging lesion patterns of patients with CAP were compared ...
DISCUSSION. It is known that the majority of thoracic aortic diseases are degenerative and occur in association with risk factors for atherosclerosis such as smoking, hypertension and hypercholesterolemia[10] and all of those had a high prevalence in our sample.. One of the factors that impact morbimortality after aortic interventions are neurologic events and progression of aortic disease[11]. TEVAR is a safe and effective procedure to treat both aneurysms and dissections involving the descending aorta with relative low risk[12,13]. The landing zone was soon extended proximally in order to treat more extensive segments of the aorta, reducing the morbimortality when compared with conventional techniques[14-16].. New totally endovascular techniques for treatment of complex aortic arch diseases are available and include stenting of the supra-aortic vessels (parallel techniques), fenestrated or branched endografts. Those are promising, but experience in aortic arch repair are very limited[17] and ...
In this study using a newly developed CNT-based micro-CT with cardiac and respiratory gating, we have successfully quantified calcification in the aortic arch plaques of living mice. CNT-based sources are able to achieve a 10 ms or better temporal resolution, not directly achievable using conventional thermionic sources. As a result, we were able to gate cardiac and respiratory motion in a straightforward manner, allowing simplified animal handling without the need for intubation.. Heart contraction causes movement of the vascular wall and thereby motion blur in the acquired image.9 In addition, because the R-wave interval at 600 beats per minute is 100 ms, errors of pulse control ,5 to 10 ms could result in significant additional blur of structures. One of the key advantages of our CNT-based micro-CT system is the ability to control the x-ray pulses to at least a microsecond level. Although in vivo imaging of arch calcification has already been reported in B6-apoE KO mice using a conventional ...
Diseases of the thoracic aorta are increasing in prevalence. In the UK, there has been a steady rise in admissions for thoracic aortic dissection (TAD) from 7.2 to 8.8 per 100 000 population over the last decade.1 At the same time, admissions for thoracic aortic aneurysms (TAA) have increased from 4.4 to 9.0 per 100 000. Thoracic aortic disease is deadly; most patients with TAA are likely to die of a complication attributable to their aneurysm, accounting for up to 47 000 deaths annually in the USA.2 TAD affecting the ascending aorta has a 30-day mortality of 25-50%.3 The increase in numbers of patients presenting with disease of the thoracic aorta is predominantly due to an increase in elderly patients, over 75 years of age.1 This means that the upward trend is likely to continue as the population ages, and that these patients are more likely to suffer from multiple additional comorbid conditions, presenting greater challenges for clinicians. In the face of this increasing problem, our ...
Aortic atheroma has been correlated with traditional cardiac risk factors, coronary, carotid, renal and peripheral atherosclerosis, and is probably a manifestation of generalized atherosclerosis. Aortic atheroma has also been shown to be associated with atrial fibrillation, aortic valve sclerosis, and other calcification of the fibrous skeleton of the heart. None of the previous studies have looked at the noninvasive prediction of aortic atheroma using the history and physical signs of cardiovascular disease. This would be a time and cost-effective bedside diagnostic tool that would be useful prior to cardiac surgery, cardiac catheterization, and workup of ischemic stroke patients, especially when transesophageal echocardiogram (TEE) is being considered for diagnosis but cannot be obtained due to previously mentioned reasons. Although physical examination of peripheral vascular disease is non-specific, a combination of physical examination signs increases the probability of generalized ...
Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta (AA). Epiaortic ultrasound scanning (EUS), the current gold standard for detecting AA atherosclerosis, has not gained widespread use because there is a lack of optimized ultrasound devices, it lengthens the procedure, it endangers sterility, and there is a false belief by many surgeons that palpation is as sensitive as EUS. Furthermore there is no clear evidence proving that the use of epiaortic scanning changes outcome in cardiac surgery. Various researchers investigated the ability of transesophageal echocardiography (TEE) to discriminate between the presence and absence of AA atherosclerosis. It is acknowledged that TEE has limited value in this, but it has never been supported by a meta-analysis estimating the true diagnostic accuracy of TEE based on all quantitative evidence. We aimed to do this using state-of-the-art methodology of diagnostic meta-analyses.. We searched multiple ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
The four major acute aortic syndromes are aortic rupture (discussed above), aortic dissection, intramural hematoma, and penetrating atherosclerotic ulcer. Aortic dissection is caused by a circumferential or, less frequently, transverse tear of the intima. It often occurs along the right lateral wall of the ascending aorta where the hydraulic shear stress is high. Another common site is the descending thoracic aorta just below the ligamentum arteriosum. The initiating event is either a primary intimal tear with secondary dissection into the media or a medial hemorrhage that dissects into and disrupts the intima. The pulsatile aortic flow then dissects along the elastic lamellar plates of the aorta and creates a false lumen. The dissection usually propagates distally down the descending aorta and into its major branches, but it may propagate proximally. Distal propagation may be limited by atherosclerotic plaque. In some cases, a secondary distal intimal disruption occurs, resulting in the reentry ...
Aortic diseases, What is a thoracic aortic aneurysm?,How is a thoracic aortic aneurysm diagnosed?Heart Care For You aim of providing comprehensive cardiac care solutions to the patients for Angioplasty Surgery, Bypass surgery, Cardiac surgery, Valve Surg
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TY - JOUR. T1 - Preoperative Noncontrast Chest Computed Tomography Identifies Potential Aortic Emboli. AU - Lee, Richard. AU - Matsutani, Noriyuki. AU - Polimenakos, Anastasios C.. AU - Levers, Lorraine C.. AU - Lee, Michelle. AU - Johnson, Robert G.. PY - 2007/7/1. Y1 - 2007/7/1. N2 - Background: Intraoperative epiaortic scanning identifies aortic atheroma. Avoiding atheroma manipulation reduces cerebral vascular accidents (CVA). Unfortunately, epiaortic scanning can only be performed after the time of sternotomy. We sought to determine whether (1) preoperative noncontrast chest computed tomography (CT) identifies areas of aorta at risk for embolization in high-risk patients, and (2) operative strategies designed at the reduction of aortic manipulation of these areas can reduce permanent strokes. Methods: The rate of permanent strokes was examined at a single institution between two time periods using the χ2 method. From January 2002 through June 2003 (pre-CT) 230 patients underwent elective ...
Cleveland Clinic surgeons performed 850 descending throacic aorta repair procedures in the past five years. The majority of these were elective operations that involved an endovascular approach.. ...
主動脈剝離(英語:aortic dissection;法語:dissection aortique;德語:Aortendissektion),又譯為「主動脈夾層」或「心血管動脈撕裂」,是因為主動脈血管內膜(英語:Tunica intima)受傷,使得血液可以流入主動脈壁各層之間,使血管層剝離(英語:Dissection (medical))的症狀[3]。大部份的情形下,在主動脈剝離時會有嚴重、撕裂狀的胸痛或是背痛(英語:Acute aortic syndrome)[1][2],同時會有嘔吐、冒汗、頭重腳輕等症狀[2]。因為無法提供足夠血液到其他器官,也會有像中風或腸繫膜缺血等症狀[2]。主動脈剝離後,因為無法提供心臟足夠的血液或是主動脈破裂(英語:Aortic rupture),可能很快會致命[2]。 主動脈剝離較常出現在有高血壓及主動脈瓣二葉畸形(英語:Bicuspid aortic ...
The Aortic Program at OHSU is a regional resource for aortic emergency care as well as routine management of aortic disease. We collaborate with your local physician and hospital to treat conditions such as descending aortic dissections, chronic thoracic aortic disease and complicated vascular disease.
An estimated 60,000 Americans are walking around with time bombs in their chests called thoracic aortic aneurysms. At any time, their main chest artery could suddenly burst open, causing massive internal bleeding that is almost always fatal.. Its possible to repair the defect before the artery bursts, but traditional surgery is highly invasive. The operation typically requires an 18-inch incision, a week or two in the hospital and three to six months to recover. There are several major risks, including stroke and paralysis.. At Loyola University Hospital, an increasing number of patients are being treated with a device called a stent graft, which is inserted without opening the chest. Stent graft patients typically go home in a day or two, and recover fully in about two weeks.. At Loyolas Thoracic Aortic Disease Clinic, about 70 percent of patients who undergo surgery for aneurysms in the chest artery are receiving stent grafts rather than open chest surgery. And as the technology evolves, we ...
Our cross-sectional study shows for the first time that higher sclerostin levels are associated independently with AD in T2DM patients. Secondly, high concentrations of sclerostin were associated with abnormal IMT, carotid plaques, and aortic calcifications in T2DM males. We found similar differences in T2DM females with abnormal IMT and aortic calcifications. Thirdly, we found a significant positive correlation among sclerostin levels, homocysteine, and IMT in T2DM patients, independently of sex.. The higher levels of sclerostin observed in T2DM patients with AD suggest a specific role of sclerostin in this process, confirming data from preclinical studies. Previous reports on the Wnt signaling antagonist sFRP (11,13) illustrated that its upregulation after injury was involved in healing and homeostasis of vascular tissue. In support of this hypothesis, data with the Wnt signaling agonist Dishevelled (Dvl) (23), which acts as a positive regulator of the Wnt pathway, showed that activation of ...
Our secondary outcomes are mean aortic wall thickness at the most diseased segment on FDG PET/ CT and vessel wall area on MRI at the most diseased segment, and we will perform analyses using a model including the same variables as above ...
Aortic aneurysm: TEVAR- Thoracic Endo Vascular Aortic Repair, , EVAR - Endo Vascular Aortic Repair, Ch EVAR / f EVAR / pevar- All these complex procedures can be done in a minimally invasive manner to treat complex aortic diseases ...
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice.. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013. The abdominal aortic calcification score (AACS) was assessed using lateral lumbar X ray, and the ankle-brachial index (ABI) using a Doppler device.. RESULTS: The median AACS was 11 (range 0 - 24). In 58% of the patients, all 4 segments of the abdominal aorta showed deposits, while 19% of patients had no visible deposits (AACS 0). Ankle-brachial index was normal in 49%, low (, 0.9) in 17%, and high (, 1.3) in 34% of patients. Altogether 91 patients (37%) died during the median follow-up ...
TY - JOUR. T1 - Transesophageal echocardiography in the diagnosis of diseases of the thoracic aorta. T2 - Part 1. Aortic dissection, aortic intramural hematoma, and penetrating atherosclerotic ulcer of the aorta. AU - Willens, Howard J.. AU - Kessler, Kenneth M.. PY - 1999/1/1. Y1 - 1999/1/1. KW - Acute aortic syndrome. KW - Aortic dissection. KW - Aortic intramural hematoma. KW - Penetrating aortic ulcer. KW - Thoracic aorta. KW - Transesophageal echocardiography. UR - UR - U2 - 10.1378/chest.116.6.1772. DO - 10.1378/chest.116.6.1772. M3 - Article. C2 - 10593804. AN - SCOPUS:0033388643. VL - 116. SP - 1772. EP - 1779. JO - Chest. JF - Chest. SN - 0012-3692. IS - 6. ER - ...
THESIS:. Objective: assess the prevalence of thoracic aortic calcification and aneurysm in patients in lung cancer screening.. Materials and methods: the retrospective study included randomly selected results of ultra-low-dose computed tomography of 254 patients.. Results: quantitative analysis of aortic calcination by Agatston, Volume, Mass index, as well as qualitative and quantitative analysis of aortic aneurysm occurrence in lung cancer screening was performed.. Conclusion: it is necessary to pay attention to the presence of thoracic aorta calcification and aneurysm in lung cancer screening, as these changes are closely associated with a high risk of cardiovascular diseases leading to death.. KEYWORDS: Aortic calcification, Aortic aneurysm, Ultra-low-dose computed tomography.. CORRESPONDING AUTHOR: Korkunova O. A. E-MAIL: [email protected] FOR CITATIONS: Korkunova O. A., Suchilova M. M., Nikolayev A. E., Grishkov S. M., Gombolevskiy V. А., Bosin V. Yu. - Aortic calcification and ...
TY - JOUR. T1 - Aortoiliac occlusive disease. AU - Schneider, J. R.. PY - 1995. Y1 - 1995. N2 - The effects of gender on patient selection and results of intervention for aortoiliac atherosclerotic occlusive disease have received little attention in published reports. Review of our experience with aortobifemoral, femorofemoral, and axillofemoral bypass identified consistently more isolated anatomic aortoiliac disease in women, but virtually indistinguishable levels of preoperative ischemia as measured by clinical and hemodynamic indices. The performance of each of these three methods of reconstruction did not appear to be affected by gender. Review of other investigators experience with these techniques as well as unilateral aortofemoral bypass, iliofemoral bypass, and PTBA did not find any evidence of discrepant performance of these latter techniques in women and men. This is in contrast to the results with infrainguinal reconstruction, which in our hands appear to be inferior in women. ...
Penetrating atherosclerotic ulcer is characterized by ulceration that penetrates through the elastic lamina into the media, and is associated with a variable amount of haematoma within the aortic wall. Haematoma formation may extend along the media, resulting in aortic dissection. In some cases, haematoma extension causes stretching of the weakened aortic wall, leading to the formation of a saccular aneurysm. Rupture is an eventual outcome. This entity has to be distinguished from atheromatous ulcers that are confined to the intima layer, aneurysms and classic aortic dissection. Although they typically involve the descending thoracic aorta (mostly the middle or distal portion), penetrating atherosclerotic ulcers can also involve the abdominal aorta and seldom are multiple. Typical CT features of penetrating ulcers include focal involvement with adjacent subintimal haematoma located beneath the frequently calcified and inwardly displaced intima, often associated with thickening or enhancement of ...
Posted By CCF CARDIO MD - MTR on September 01, 1998 at 11:51:15: In Reply to: Aortic Root Dilation posted by Jay on August 31, 1998 at 00:48:01: _____ Dear Jay, than...
This study was undertaken to analyze immediate and mid-term knitted Dacron graft dilation and to establish which parameters should be taken as a reference when aortic graft dilation is evaluated. A Dacron knitted microvel double velour vascular graft (Hemashield Gold) was implanted in 30 patients with aneurysmal (19 cases, 63%) or occlusive (11 cases, 37%) aortic disease. The stems of bifurcated prostheses (27 patients, 90%) and tube grafts (3 patients, 10%) were measured. The package sizing (labelled size) was compared with the external diameter measured intraoperatively with a slide caliper, prior to implantation and after complete clamp release. Additional measurements were obtained by ultrasound 1 and 6 months after implantation, and in 16 cases (53% of the patients) ultrasound and computed tomography (CT) were performed at the end of the first year. The means of the measurements were compared using Students t test for matched pairs. The statistical significance level was set at p values | 0.05.
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Open aortic surgery is employed for patients who have indications for abdominal aortic aneurysm (AAA) repair but unfavorable anatomy for endovascular aortic repair. Open aortic surgery is also necessary to manage aortic thrombosis or repair of aortic
The purpose of this study was to compare two non-contrast 2D techniques with the current contrast-enhanced MRI standard 3D technique for the routine assessment of thoracic aortic pathologies. One hund
Can someone help shed some light for me...Im a 31 year old male, 63 210lbs with a history of hypertension that is controlled using lopressor. Recent echo, which was a follow up from a previous one done 2.5 years ago, showed an aortic root measuring 4.1cm at the sinus of valsalva. The physician documented this as mildly dilated. This is an increase from 3.8cm in 2013. Valve is trileaflet with no regurgitation noted. I have a follow up appointment on the 21st with my cardiologist. My question the term dilated and aneurysm the same thing ...
TY - JOUR. T1 - Ultrasonographic images of spontaneous intramural hematomas of the intestinal wall in two patients with congenital bleeding tendency. AU - Gamba, G.. AU - Carnevale Maffe, G.. AU - Mosconi, E.. AU - Tibaldi, A.. AU - Di Domenico, G.. AU - Frego, R.. PY - 1995. Y1 - 1995. UR - UR - M3 - Article. VL - 80. SP - 388. EP - 389. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 4. ER - ...
Semantic Scholar extracted view of [Case of intramural hematoma of the small intestine caused by anticoagulants]. by Hiroki Sato et al.
Thornton, M, Jones, L, Jones, A, Murphy, K, Rees, M, Smith, F, Lamont, P & Baird, R, 1998, Use of intravascular ultrasound (IVUS) in stenting for aortic occlusive disease . European Journal of Ultrasound, vol 7. Full details in the University publications repository. ...
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With the advent of helical CT, the capability of noninvasive imaging of the thoracic aorta has been enhanced considerably. In this article, we describe the potential of helical CT using dual-slice technology to evaluate thoracic aortic diseases such
Background: Despite the successful development in cardiac surgery, cerebrovascular accidents (CVA) remain a devastating complication. Aortic atherosclerosis has been identified as a major risk factor for CVA. The present thesis addresses this question in relation to aortic manipulation during cardiac surgery, being divided into a clinical (I-II) and an experimental part (III-V).. Material and methods: Consecutive cardiac surgery cases (n=2641) were analyzed. Patients with CVA were extracted from a database designed to monitor clinical symptoms. Patient records were used to confirm clinical data and diagnosis. Subdivision was made into three groups: control subjects, immediate, and delayed CVA, being analyzed for neurological symptoms (I). Patients with CVA who also had been investigated with computer tomography (CT) (n=77) were further evaluated in terms of hemispheric and vascular distribution of lesions. The CT-findings were compared with CVA symptoms (II). An aortic perfusion model was ...
Our program is internationally recognized for the surgical treatment of thoracic aortic disease, coronary artery disease, and valvular disease....
Atıf İçin Kopyala Kaya D. , Yildiz E. CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.111, sa.5, ss.415-421, 2009 (SCI İndekslerine Giren Dergi) ...
...HOUSTON (Nov. 18 2010) Discovery of a fifth gene defect and the ide...In both studies the investigators have identified alterations in the ... Both discoveries are more confirmation of the role that proper contra...In thoracic aortic disease the deterioration of the wall of the aorta...,UTHealth,discoveries,shed,more,light,on,deadly,thoracic,aortic,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
A method and device for occluding a patients ascending aorta, maintaining circulation of oxygenated blood in the patient and delivering cardioplegic fluid to arrest the patients heart. An aortic occlusion catheter has an occluding member for occluding the ascending aorta. The aortic occlusion catheter passes through a cannula. Delivery of oxygenated blood is accomplished through either the cannula or the aortic occlusion catheter.
Transesophageal MRI of human thoracic aortae demonstrate the feasibility of the technique in healthy volunteers (Fig. 2A)and among patients with aortic atherosclerosis (Fig. 2B-D). Figure 2C, Dshows the corresponding TEMRI and TEE images of the distal aortic arch in a 77-year-old male patient with remote stroke, depicting heterogeneous atherosclerotic thickening, and this illustrates differences in circumferential plaque extent by the two methods. Figure 2Eis a longitudinal slice through the descending thoracic aorta and a portion of the arch of a normal subject, demonstrating the nonuniform SNR of the device (9,12). The SNR decreases linearly with radial distance from the probe, but substantially maintains its SNR along much of its length. In practical terms, this property allows TEMRI at multiple longitudinal locations over ∼20 cm without the need for repositioning the device.. Maximum and minimum WTs were 3.5 ± 1.2 mm and 1.2 ± 0.8 mm by TEE, and 3.3 ± 1.5 mm and 1.0 ± 0.7 mm by TEMRI, ...
The epidemic of diabetes and obesity assailing Westernized societies threatens to interact with the prevalent, age-related incidence of aortic disease to increase macrovascular disease burden.3 Primary prevention strategies are critically important; however, as many as one-third of patients with T2DM may be unaware of their disorder-and vascular disease processes that threaten life, limb, and autonomy progress from the earliest phases of the dysmetabolic state.1,2 A better understanding of aortofemoral disease in T2DM is necessary to develop new strategies to address this burgeoning clinical need.. The Ldlr−/− mouse has emerged as one useful model for studying macrovascular injury in response to T2DM.17 When fed HFD, these mice become obese, with concomitant hyperglycemia and dyslipidemia.17 Unlike the Apoe−/− mouse-a model of atherosclerosis in the absence of hyperglycemia and obesity17 Ldlr−/− mice fed the HFD elaborate key features of metabolic syndrome.17 The relationships ...
torso: Aortic aneurysm *Abdominal aortic aneurysm. *Thoracic aortic aneurysm. *Aneurysm of sinus of Valsalva ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 827. ISBN 0-7216-2921-0.. ... Mondor's disease (also known as "Mondor's syndrome of superficial thrombophlebitis"[2]) is a rare condition which involves ... Patients with this disease often have abrupt onset of superficial pain, with possible swelling and redness of a limited area of ...
torso: Aortic aneurysm *Abdominal aortic aneurysm. *Thoracic aortic aneurysm. *Aneurysm of sinus of Valsalva ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... "Epidemiology of Hypertensive Kidney Disease".. CS1 maint: uses authors parameter (link). *^ Rowe, D J; Bagga, H; Betts, P B ( ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ...
MYH11 Aortic aneurysm, familial thoracic 6; 611788; ACTA2 Aortic valve disease; 109730; NOTCH1 Apert syndrome; 101200; FGFR2 ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
Skeletal deformities and aortic valve disease may occur. These patients may live into adulthood. MPS I is inherited in an ... Aortic valve disease may occur. Upper and lower respiratory-tract infections can be frequent. Most children develop limited ... Mucopolysaccharidosis type I is a spectrum of diseases in the mucopolysaccharidosis family. It results in the buildup of ... the person should not show any symptoms of the disease. MPS I is divided into three subtypes based on severity of symptoms. All ...
Aortic valve disease may occur. Airway obstruction is frequent, usually secondary to abnormal cervical vertebrae. Upper and ... A similar disease of "gargoylism" had been described in 1917 by Charles A. Hunter. Hurler did not mention Hunter's paper. ... Most vectors can correct the disease in the liver and spleen, and can correct brain effects with a high dosage. Gene therapy ... The Storage Disease Collaborative Study Group". Blood. 91 (7): 2601-8. doi:10.1182/blood.V91.7.2601. PMID 9516162. Staba SL, ...
The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC) (1 November 2014 ... "Imaging of thoracic aortic disease". The British Journal of Radiology. 84 (3): S338-S354. doi:10.1259/bjr/30655825. PMC 3473913 ... "2014 ESC Guidelines on the diagnosis and treatment of aortic diseases". European Heart Journal. 35 (41): 2873-2926. doi:10.1093 ... The diagnosis of aortic dissection can be made by visualization of the intimal flap and flow of contrast material in both the ...
"Aortic Disease and Management in India". In Alan Dardik (ed.). Vascular Surgery: A Global Perspective. Springer. p. 64. doi: ... Sen was one of the first to perform aortic surgery in the 1950s, laying the foundations at first for aortic surgery and than ... In the 1950s he turned his attention from aortic surgery to open heart surgery following numerous experiments on dogs. He ... SEN, PK; Kinare, SG; Engineer, SD; Parulkar, GB (1963). "The middle aortic syndrome". Br Heart J. 25: 610-8. doi:10.1136/hrt. ...
Goldbarg, Seth H; Halperin, Jonathan L (May 2008). "Aortic regurgitation: disease progression and management". Nature Clinical ... Clinical investigation topics include congestive heart failure, Raynaud's disease and mitral valve disease. Extramural honors ... He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in ... December 2008). "ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American ...
Patients referred for this procedure may have Coronary Artery Disease (CAD); aortic, mitral or tricuspid valve diseases; or ... Other centers that utilize the MICS CABG technique for coronary heart disease are the University of Ottawa Heart Center (ON, ... 92% of patients were free from angina and none of the participants experienced any aortic complications, repeat ... Coronary artery bypass Mitral valve repair Mitral valve replacement Aortic valve replacement Atrial septal defects Hybrid ...
Barres, Alfred G. (1892-03-12). "On the Use of Digitalis in Aortic Disease". Br Med J. 1 (1628): 542-544. doi:10.1136/bmj. ... The areas he worked in included cardiac disease, publishing a paper in the British Medical Journal on the subject in 1892, and ...
Milan B, Josip K (November 1967). "Ocular manifestations of the aortic arch syndrome (pulseless disease; Takayasu's disease) ( ... Takayasu's arteritis (TA), also known as aortic arch syndrome, nonspecific aortoarteritis, and pulseless disease, is a form of ... Those with the disease often notice symptoms between 15 and 30 years of age. In the Western world, atherosclerosis is a more ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. American College of ...
Milewicz DM, Dietz HC, Miller DC (March 2005). "Treatment of aortic disease in patients with Marfan syndrome". Circulation. 111 ... ß-blocker medication for aortic protection and prophylactic replacement of the aortic root. In MFS affected adults, it is ... Marfan Syndrome is a congenital disease that arises from a mutation in the FBN-1 gene. This leads to the malformation and ... This provides the explanation for the aortic aneurysms and prolapsed valves that are commonly associated with Marfan Syndrome. ...
Milewicz DM, Dietz HC, Miller DC (March 2005). "Treatment of aortic disease in patients with Marfan syndrome". Circulation. 111 ... Aortic specific symptoms are closely related to excessive TGF-ß signalling in the aortic root wall.[22] TGF-ß antagonism via ... Aortic specific symptoms are closely related to excessive TGF-ß signalling in the aortic root wall.[22] TGF-ß antagonism via ... more specifically changes in the aortic wall and progressive aortic dilation.[22] Antagonism of TGF-ß also further reduced MFS ...
Aortic valve stenosis and mitral valve dysplasia are heart diseases. Diagnosis is made by colour doppler echocardiography ... Polycystic kidney disease (PKD) and Bull Terrier hereditary nephritis (BTHN) are autosomal dominant diseases. PKD is diagnosed ... PLL is a late onset disease which typically affects dogs between the ages of mid 2 and 7. Younger and older cases are known. ... Dogs with a score of .3 or below are considered clear of the disease. Clearing breeding stock prior to use ensures that progeny ...
August 2002). "Aortic cusp extension valvuloplasty for rheumatic aortic valve disease: midterm results". The Annals of Thoracic ... May 2003). "Long-term evaluation of the replacement of the trachea with an autologous aortic graft". The Annals of Thoracic ...
Medical examinations discovered serious aortic calcification and some coronary artery disease. Meanwhile, Kimball had ... First, an aortic valve replacement would be required. Second, an important coronary artery with a blockage should be treated ...
Dissection of the aortic arch is rare due to medial scarring. As a result of this advanced disease process, normal methods of ... If the disease progresses, syphilitic aortitis leads to an aortic aneurysm. Overall, tertiary syphilis is a rare cause of ... The infection often has no symptoms until the patient develops an aneurysm because of the aortic dilatation.The disease is ... This leads to narrowing of the lumen of the vasa vasorum, causing ischemic injury of the medial aortic arch and then finally ...
In humans, mutations in Notch most often result in bicuspid aortic valve disease and calcification of the aortic valve. Bone ... Garg V. et al "Mutations in NOTCH1 cause aortic valve disease." Nature September 2005 437(7056) p 270 - 274. doi:10.1038/ ... Other outcomes of aortic arch artery anomalies includes a double aortic arch, variable absence of the carotid arteries and left ... The group of cells found in the third aortic arch gives rise to common carotid arteries. Cells found in the fourth aortic arch ...
"Impact of aortic stiffness on survival in end-stage renal disease". Circulation. 99 (18): 2434-9. doi:10.1161/01.cir.99.18.2434 ... Increased aortic PWV has been shown to predict cardiovascular, and in some cases all cause, mortality in individuals with end ... Typical values of PWV in the aorta range from approximately 5 m/s to >15 m/s. Measurement of aortic PWV provides some of the ... Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A (May 2001). "Aortic stiffness is an ...
"Validation of the murine aortic arch as a model to study human vascular diseases". Journal of Anatomy. 216 (5): 563-571. doi: ... In the spread of disease. Rats can serve as zoonotic vectors for certain pathogens and thus spread disease, such as bubonic ... "CDC - Diseases directly transmitted by rodents - Rodents". Centers for Disease Control. 2011-06-07. Archived from the original ... Another zoonotic disease linked to the rat is foot-and-mouth disease.[7] ...
Rivière is credited as the first physician to describe aortic valve disease. During an autopsy of a patient in 1646 who died ... He further observed that the aortic valve was "hardened." This work was described by French Physician René Laennec as the first ... During his career he specialized in pharmacology, anatomy, and surgery and was the first physician to describe aortic valve ... His works covered a variety of medical topics including the history of epidemics, surgical methods, disease descriptions, ...
However, TIAs can result from emboli in calcific aortic disease and aortic coarctation. Spinal arteriovenous malformations ( ... Gradual onset diseases are more common (85-90% of all diseases leading to a diagnosis of malformation) and are usually due to ... Malformations can be recognised as part of an acute illness or gradual onset disease. In diseases such as subarachnoid ... Vascular myelopathy (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood ...
... he suffered from narrowing of the aortic valve related to rheumatic heart disease. As Smithy began to operate on a series of ... In late June, Smithy sent Blalock a letter indicating that he had a young man from New York whose aortic stenosis was nearly ... On October 28, Smithy died; he had never been able to undergo surgery on his own aortic valve. An autopsy later showed that the ... By 1946, Smithy had devised what he called a valvulotome, an instrument he used to cut away scar tissue from the aortic valve. ...
Single-valve disease (aortic) treated with a two-valve procedure (aortic and pulmonary). One of the main objections to the Ross ... Chambers J, Somerville J, Stone S, Ross D (1997). "Pulmonary autograft procedure for aortic valve disease: long-term results of ... procedure is the genesis of pulmonary valve disease in addition to aortic valve disease. Proponents have argued that biological ... Homografts (aortic or pulmonary) should be the replacement of choice; no other valve performed as well in the pulmonary ...
Heart Disease - the most common heart problems are aortic stenosis, mitral valve dysplasia, cardiomyopathy; Eyes Disease - the ... "Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) in Black Russian Terriers". Canine Genetic Diseases Network. Retrieved 19 ... however it is prone to certain hereditary diseases: Major concerns: Hip dysplasia Elbow dysplasia Hyperuricosuria Juvenile ... a nutritionally based developmental disease especially in young, heavy, fast-growing puppies; Panosteitis (Pano or Wandering ...
Mansfield died of an aortic disease in Washington, D.C., on January 29, 2013. Gordon H. Mansfield. "Gordon H. Mansfield - The ...
"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms". The Journal of Thoracic ... A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote ... This was a significant interaction as Presenilin is implicated in the development of Alzheimer's disease. This and further ... June 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754 ...
The cause of death was recorded as "heart disease, aortic insufficiency, and probably myocarditis." Edmund Kirby Smith, the ... In April and May, the Confederates lost almost as many men to death by disease in Corinth as had been killed in battle at ...
"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms". J Thorac Cardiovasc Surg ... A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote ...
Crohn's disease - Gastritis, gallstones, peptic ulcer, abdominal aortic aneurysm, constipation, irritable bowel syndrome, ... Incidence (rate of newly diagnosed cases of the disease during a specified period of time, e.g., one month or one year); Period ... Cause of the disease (if known). Try to separate from risk factors, although some overlap is common. ... Heart disease - Smoking; high blood pressure; high cholesterol; obesity; family history (genetics). Kata. opsional. ...
He suffered from aortic stenosis and no longer had access to follow-up treatment for his earlier cancer.[391] A stroke left him ... there he was diagnosed with Hodgkin's disease.[376] In mid-1984, Office 131 was moved to a new base further into Cambodia, near ...
Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease». Gastroenterology. 139 (1): ...
"Detection of Borrelia bissettii in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech ... "Lyme disease rashes and look-alikes". Lyme Disease. Centers for Disease Control and Prevention. 21 December 2018. Archived from ... "Lyme Disease Data and surveillance". Lyme Disease. Centers for Disease Control and Prevention. 5 February 2019. Archived from ... Treatment regimens for Lyme disease range from 14 days in early localized disease, to 14-21 days in early disseminated disease ...
Altering the progression of left sided heart disease". Progress in Pediatric Cardiology. 22: 71-78. doi:10.1016/j.ppedcard. ... Fetal aortic stenosis is a disorder that occurs when the fetus' aortic valve does not fully open during development. The aortic ... Then a 0.014 inch guide wire is passed across the stenosis aortic valve, where a balloon is inflated to stretch the aortic ... resulting in systemic circulation failure in babies born with aortic valve stenosis. Fetal aortic valve stenosis can be ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... and paired aortic arches.[69] ... a common skin disease in snakes and lizards, will occur when ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... "Rattlesnake bite in a patient with horse allergy and von Willebrand's disease: case report". Can Fam Physician. 42: 2207-2211 ...
Possible pregnancy, liver disease, high alcohol consumption, and smoking are indications for close monitoring and limitation of ... "Increased dietary intake of vitamin A promotes aortic valve calcification in vivo". Arteriosclerosis, Thrombosis, and Vascular ... Gundermann KJ, Kuenker A, Kuntz E, Droździk M (2011). "Activity of essential phospholipids (EPL) from soybean in liver diseases ... hyena disease): a historical review of the human and veterinary literature". Pediatric Radiology. 37 (12): 1264-7. doi:10.1007/ ...
Other uncommon causes are Trousseau disease,[medical citation needed] Beurger's disease (Thromboangiitis obliterans),[medical ... torso: Aortic aneurysm *Abdominal aortic aneurysm. *Thoracic aortic aneurysm. *Aneurysm of sinus of Valsalva ... One in five of the middle-aged (65-75 years) population of the United Kingdom have evidence of peripheral arterial disease on ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ...
... connective tissue disease), ହାଇପୋଥାଇରଏଡିଜ୍ମ, ଆଓର୍ଟିକ ରପଚର (aortic rupture) ଓ ହୃତ୍‌ପିଣ୍ଡ ଅପରେଶନ (cardiac surgery) ପରେ ଏହି ରୋଗ ...
... aortic disease (e.g. aortic aneurysm),[56] high blood pressure,[57][58] stroke,[59] diabetes, clinical depression,[60] weight ... "Journal of Thoracic Disease. 7 (8): 1311-1322. doi:10.3978/j.issn.2072-1439.2015.06.11. PMC 4561280. PMID 26380759.. ... Stroke and other cardiovascular disease are related to OSA and those under the age of 70 have an increased risk of early death. ... OSA accompanied by daytime sleepiness is estimated to affect 3% to 7% of men and 2% to 5% of women, and the disease is common ...
Lidwell M C, "Cardiac Disease in Relation to Anaesthesia" in Transactions of the Third Session, Australasian Medical Congress, ... The epicardial pacemaker leads were placed after the patient collapsed during aortic valve surgery. In the first half of the ... These studies demonstrated the restoration of heart rate, cardiac output and mean aortic pressures in animal subjects with ... sinus node disease (SND) or sick sinus syndrome. Where the problem is atrioventricular block (AVB) the pacemaker is required to ...
Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as ... forming the ligamentum arteriosum between the pulmonary trunk and aortic arch. It also plays a role in the constriction and ...
心包填塞常見的病因包含癌症、腎衰竭、胸腔損傷(英语:chest trauma)和心包炎[2]。其他病因包括結締組織病(英语
It passes beneath the aortic arch, crosses in front of the esophagus, the thoracic duct, and the descending aorta, and has the ... It can have multiple variations and, although usually asymptomatic, it can be the root cause of pulmonary disease such as a ... Mainstem bronchi seen branching off the trachea (labeled at top), with the left mainstem bronchi passing below the aortic arch ... Many sufferers of chronic bronchitis also suffer from chronic obstructive pulmonary disease (COPD), and this is usually ...
Coronary disease. *Coronary artery disease (CAD). *Coronary artery aneurysm. *Spontaneous coronary artery dissection (SCAD) ...
Forrester JS, Litvack F, Grundfest W, Hickey A (1987). "A perspective of coronary disease seen through the arteries of living ... Aortic aneurysm / dissection:. *Endovascular aneurysm repair. *Open aortic surgery. Other. *Cardiopulmonary bypass ...
Vascular disease. Arterial. *aortic aneurysm (Cardarelli's sign, Oliver's sign). *pulmonary embolism (McConnell's sign) ...
Demyelinating disease, hipoglisemia, hiperglisemia, primary ocular disease-glaucoma, vitreal hemorrhage. floaters and the like ... "Papillary Fibroelastoma of the Aortic Valve as a Cause of Transient Ischemic Attack". Department of Cardiovascular Surgery, ... "Cerebrovascular Disease Service, Palmer 127, West Campus, Beth Israel Deaconess Medical Center; Caplan LR. Diakses tanggal 2011 ... ASCO merupakan akronim dari atherothrombosis, small vessel disease, cardiac causes, and other uncommon causes. Sistem ASCO ...
Cardiovascular disease[edit]. Evidence suggests that dietary vitamin D may be carried by lipoprotein particles into cells of ... "Relation of oral 1alpha-hydroxy vitamin D3 to the progression of aortic arch calcification in hemodialysis patients". Heart and ... "Vascular calcification: pathobiology of a multifaceted disease". Circulation. 117 (22): 2938-48. doi:10.1161/CIRCULATIONAHA. ...
Crohn's disease - Gastritis, gallstones, peptic ulcer, abdominal aortic aneurysm, constipation, irritable bowel syndrome, ... Heart disease - Smoking; high blood pressure; high cholesterol; obesity; family history (genetics). स्ट्रिंग. वैकल्पिक. ... Incidence (rate of newly diagnosed cases of the disease during a specified period of time, e.g., one month or one year); Period ... Cause of the disease (if known). Try to separate from risk factors, although some overlap is common. ...
Discovery of anti-TNF therapy as an effective treatment for rheumatoid arthritis and other autoimmune diseases.[47] ... The development of prosthetic mitral and aortic valves, which have prolonged and enhanced the lives of millions of people with ... Development of renal hemodialysis, which changed kidney failure from a fatal to a treatable disease, prolonging the useful ... For 50 years of international statesmanship in biomedical science-exemplified by discoveries concerning genetic diseases of the ...
a b Tutarel, O. (2004). The quadricuspid aortic valve: a comprehensive review. The Journal of Heart Valve Disease, 13(4), 534- ... Quadricuspid aortic valve. A quadricuspid aortic valve (QAV) is a rare congenital heart defect characterized by the presence of ... A short-axis ultrasound of the aortic valve allows for the best view of the aortic valve, and gives a clear indication of the ... The typical method of treatment is through surgery such as aortic valve reconstruction surgery (AVRS) and aortic valve ...
... the type of disease, and the severity of the disease. For example, valvular disease of the aortic valve, such as aortic ... Equations for the aortic valve in this case: ρ. (. ∂. u. ∂. t. +. u. ∂. u. ∂. x. ). +. ∂. p. ∂. x. =. 0. {\displaystyle {\rho ... Disease of the heart valves can be congenital, such as aortic regurgitation or acquired, for example infective endocarditis. ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ...
The risks of developing a life-threatening disease affecting the heart or brain increase as the blood flow increases. Commonly ... and aortic dissection. Other end-organ damage can include acute kidney failure or insufficiency, retinopathy, eclampsia, and ... Other common causes of hypertensive crises are autonomic hyperactivity such as pheochromocytoma, collagen-vascular diseases, ... preexisting diabetes or coronary artery disease, mental illness, and sedentary lifestyle.[3] Several studies have concluded ...
In birds, the main arteries taking blood away from the heart originate from the right aortic arch (or pharyngeal arch), unlike ... Wurster, D.; Wurster, C.; Strickland, W. (July 1965). "Bird Mortality Following DDT Spray for Dutch Elm Disease". Ecology. 46 ( ... Wurster, C. F.; Wurster, D. H.; Strickland, W. N. (1965). "Bird Mortality after Spraying for Dutch Elm Disease with DDT". ... Birds can act as vectors for spreading diseases such as psittacosis, salmonellosis, campylobacteriosis, mycobacteriosis (avian ...
Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 81-137. doi: ... High pressure receptors called baroreceptors in the walls of the aortic arch and carotid sinus (at the beginning of the ... Many diseases are the result of a homeostatic failure. Almost any homeostatic component can malfunction either as a result of ... Various chronic diseases are kept under control by homeostatic compensation, which masks a problem by compensating for it ( ...
റെയ്നോഡ്സ് രോഗം (Raynaud's disease),[17] ചിൽബ്ളേയ് ൻ(Chilblain),[18] ഫ്രോസ്റ്റ് ബൈറ്റ്[19] (Frost bite) എന്നീ രോഗങ്ങളും ധമനികളെ ... *↑ ... *↑ ...
However, this disease highlights the importance of the thymus in prevention of autoimmunity. This disease is caused by ... It lies beneath the sternum, rests on the pericardium, and is separated from the aortic arch and great vessels by a layer of ... Patients with APECED develop an autoimmune disease that affects multiple endocrine tissues. A GVHD-like disease called thymoma- ... The end result is a disease virtually indistinguishable from GVHD. Myasthenia gravis is an autoimmune disease caused by ...
Valvular heart disease, mainly calcification and regurgitation of the aortic and mitral valves, may occur, and in severe and ... Very occasionally the disease appears to be transmitted in an autosomal dominant fashion, where a single abnormal copy of HGD ... Alkaptonuria is a rare disease; it occurs in one in 250,000 people, but is more common in Slovakia and the Dominican Republic. ... Patients with black bone disease are asymptomatic as children or young adults, but their urine may turn brown or even inky ...
Aortic diseases. Definition. Aortic diseases are pathological conditions affecting a section of the aorta, the largest artery ... Aortic diseases: FBN1 mutation affects survival in Marfan syndrome *Gregory B. Lim ... Patient-specific Computational Hemodynamic Analysis for Interrupted Aortic Arch in an Adult: Implications for Aortic Dissection ... Abdominal aortic aneurysm: update on pathogenesis and medical treatments This Review discusses the latest findings and current ...
... the aortic valve, one of the four valves in the heart. Description The most common valvular problem in old age is aortic valve ... Definition Aortic Valve Disease entails damage to, and dysfunction of, ... Aortic Valve Disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. ... Aortic valve disease can be congenital, result from infection, occur as a result of rheumatic heart disease, result from the ...
values for the aortic root but not the other two. Both reports say an aortic root is normal all the way up to 3.7 cm so I am ... Aortic Root (M-Mode): 3.4cm Aortic Root (2-D): 3.54cm Sinotubular junction: 2.76cm Ascending Aorta: 2.64cm *The report states ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... The surgeons recently replaced my aortic valve and ascending aorta when the ascending aortic aneursym reached the size of 5.0. ...
Aortic disease kills more than 15,000 people every year in the United States. Heres what you need to know about this deadly ... A chest X-ray or EKG wont necessarily spot aortic problems.. A family history of aortic disease puts you at higher risk. There ... What is aortic disease?. Your aorta is the main vessel that transports blood away from the heart and sends it to the rest of ... Aortic Dissection Killed John Ritter... What His Widow Wants Everyone to Know About the Disease. Written by David Mills on ...
Enlarged vs dilated aortic root. These two descriptive terms commonly appear on cardiac reports, and are often used ... There is no perfect aortic root size,but I would say if your aortic root does not change (,0.1cm) in the next 2 years and ... There is no perfect aortic root size,but I would say if a person has aortic root measuring 3.9 cm that does not change/increase ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ...
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active ... Animal Models of Calcific Aortic Valve Disease. Krista L. Sider,1 Mark C. Blaser,1 and Craig A. Simmons1,2,3 ...
The 12-fold increased risk for aortic disease associated with this duplication of this region of chromosome 16 is greater than ... Patients with thoracic aortic aneurysms that lead to acute aortic dissections are 12 times more likely to have duplications in ... UTHealth Researchers Link Chromosome Region To Thoracic Aortic Disease. by Sam Savage ... neuropsychiatic conditions and thoracic aortic disease.". This region of chromosome 16 (16p13.1) contains nine genes and the ...
Mitral valve disease, Aortic ulcer, Thoracic aortic aneurysm, Aortic dissection, Aortic valve disease, Coronary artery disease ... Aortic valve stenosis, Aortic aneurysm, Coronary artery disease, Heart disease, Mitral valve disease, Mitral valve prolapse, ... Transcatheter aortic valve replacement, ECMO, Aortic aneurysm, Aortic valve disease, Mitral valve disease, Coronary artery ... Aortic valve disease, Structural heart disease, Coronary artery disease, Heart valve disease ...
Aortic disorders are diagnosed and treated in pediatric and adult patients by a multidisciplinary team of cardiologists to ... How are Aortic Disorders and Diseases Diagnosed?. Aortic disorders often require a team approach to diagnosis. Your medical ... Aortic disorders or diseases result when your aorta is weakened or damaged, usually due to one of the following conditions:. * ... Peripheral vascular disease. Why Choose Loyola for Aortic Disorder Treatment?. Loyolas cardiology and heart surgery program is ...
Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke: the French Study of Aortic Plaques ... Abdominal Aortic Aneurysm. Severe thoracic aortic plaque was found in twice as many patients with abdominal aortic aneurysm on ... Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med. 1994; 331: 1474-1479. ... was also significantly associated with aortic plaque on TEE.37 Aortic plaque was present in 86% of those with aortic valve ...
Aortic valve disease refers to damage to the aortic valve, causing it not to function properly. ... The aortic valve controls the flow of blood pumped out of your heart from the left ventricle into the aorta, the main artery ... Aortic Valve Disease Symptoms and Diagnosis. Types of aortic valve disease include: * Aortic stenosis, when the aortic valve ... Bicuspid aortic valve disease, a congenital defect affecting the aortic valve. * Aortic valve endocarditis, when your aortic ...
... and other conditions and diseases. Our team treats a full range of aortic diseases, including:. Aortic Aneurysm. Aortic ... Aortic Dissection. Aortic dissection occurs when the wall of the aorta bulges so much that the layers of the aortic wall tear. ... Home / Services / Heart Surgery / Conditions & Treatments / Aortic Disease. Heart Surgery. Heart Surgery Home * Conditions & ... Hemi and Full Arch Aortic Aneurysm Repairs: If you have an at-risk section of your aortic arch, such as due to an aneurysm ( ...
The evolving epidemiology of valvular aortic stenosis. The Tromsø Study Gry Wisthus Eveborn, Henrik Schirmer, Geir Heggelund, ... Drug-induced valvular heart disease Bernard Cosyns, Steven Droogmans, Raphael Rosenhek, Patrizio Lancellotti ... Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction Rafal ... Sudden cardiac arrest in adolescence: the case of ventricular fibrillation 11 years after presenting with Kawasakis disease ...
Midaortic pseudoaneurysm complicating extensive endovascular stenting of aortic disease.. Cutry AF1, Whitley D, Patterson RB. ... A 59-year-old man who had Leriche syndrome underwent bilateral iliac artery and infrarenal aortic stent placement at another ... This case illustrates a potential life-threatening complication of extensive stent placement for aortoiliac occlusive disease. ...
In thoracic aortic disease, the wall of the aorta, the main blood vessel leading out of the heart, weakens and forms an ... Researchers have now discovered nine different genes linked to familial thoracic aortic disease. Family members who have ... UTHealth Researchers Link PRKG1 Genetic Mutation To Thoracic Aortic Disease. by editor ... He was also found to have aortic root dilation and because of his family history of early thoracic aortic dissections at ...
R. V. Freeman and C. M. Otto, "Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment ... MicroRNA Expression Signature in Human Calcific Aortic Valve Disease. Hui Wang,1 Jing Shi,1 Beibei Li,1 Qiulian Zhou,2 ... N. M. Rajamannan, F. J. Evans, E. Aikawa et al., "Calcific aortic valve disease: not simply a degenerative process: a review ... G. Latsios, D. Tousoulis, E. Androulakis et al., "Monitoring calcific aortic valve disease: the role of biomarkers," Current ...
Proliferative, degradative smooth muscle cells promote aortic disease. Maarten Hulsmans1 and Matthias Nahrendorf1,2,3 1Center ... Traditionally, thoracic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in ... phenotype also worsens atherosclerotic disease and could thus be considered as a therapeutic target for diverse aortic diseases ... mTOR-dependent proliferative SMCs render the aortic wall vulnerable to dilatation and dissection rather than prevent disease ...
I had a double cath on 8/7 which showed a severe aortic st... ... I was born with bicuspid aortic valve disease. I say all this ... Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... Lyme Disease Multiple Sclerosis Parkinsons Disease Prostate Cancer ... I had a double cath on 8/7 which showed a severe aortic stenosis, as well as a twisted stent (I have 7 of them) in a vessel. ...
... including aortic valve regurgitation and aortic stenosis, how these diseases affect the heart, and common symptoms. ... ABOUT AORTIC VALVE DISEASE. A diagnosis of aortic valve disease means your aortic valve doesnt work properly. The aortic valve ... Aortic Regurgitation. Aortic valve regurgitation, or aortic insufficiency, occurs when the aortic valve does not close tightly ... There are two types of aortic valve disease - aortic regurgitation and aortic stenosis. ...
Surgery for Aortic and Peripheral Vascular Disease. Endovascular Treatment of Thoracic Aortic Disease. Four Years of Experience ... Endovascular Treatment of Thoracic Aortic Disease. Alessandro S. Bortone, Emanuela De Cillis, Donato DAgostino and Luigi de ... Endovascular Treatment of Thoracic Aortic Disease. Alessandro S. Bortone, Emanuela De Cillis, Donato DAgostino and Luigi de ... Moreover, we were not able to compare the groups because they had different aortic diseases. The high mortality rate of the ...
Could you have aortic valve disease? Find out here. ... Aortic valve disease is when the aortic valve between the left ... Aortic valve disease occurs when stenosis, regurgitation or, in really unlucky people, both cause the aortic valve not to work ... Aortic Valve Disease. 2008. (Oct. 13, 2008) ... An aortic valve that started off too narrow from birth also can lead to stenosis (called congenital aortic valve disease). ...
What is aortic valve disease? Eric Horlick: A normal aortic valve is between four to five centimetres square and all of the ... EH: The normal treatment for severe aortic valve disease is surgery - we take out the old aortic valve and sew in a new one. ... The average patient with aortic valve disease has a narrowed aortic valve, which puts them at tremendous risk. ... With aortic valve disease, the hearts flow is capped. Even if the "tap" is on full tilt, only a trickle of blood flows through ...
I have a bicuspid aortic valve and Im addicted to weightlifting and cardio exercises. Post Edited (bunan) : 7/2/2009 12:51:14 ... Is there any relation between strenuous exercise and aortic dissection? ... Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... if you have a bicuspid aortic valve, you have to be screened for ascending aortic aneurysm, because many times an aneurysm ...
This topic contains 8 study abstracts on Aortic Plaques indicating that the following substances may be helpful: Alcohol, ... Diseases : Aortic Plaques, Aortic Stenosis, Atherosclerosis, Endothelial Dysfunction, High Cholesterol, Intima Media Thickening ... Diseases : Aortic Plaques, Atherosclerosis, Intima Media Thickening Additional Keywords : Drug: Simvastatin, Food as Medicine, ... Diseases : Aortic Plaques, Intima Media Thickening Pharmacological Actions : Cardioprotective, Matrix metalloproteinase-2 (MMP- ...
This topic contains 6 study abstracts on Aortic Aneurysm indicating that the following substances may be helpful: Antioxidant ... Diseases : Aortic Aneurysm, Arterial Calcification, Arteriosclerosis, Cardiovascular Diseases. Additional Keywords : Diseases ... Diseases : Aortic Aneurysm, Nicotine/Tobacco Toxicity Pharmacological Actions : Antioxidants, Matrix Metalloproteinase-12 (MMP- ... Diseases : Aortic Aneurysm. Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 ...
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... is a cause of aortic valve disease -- a serious heart condition that affects around five million people in North America and is ... and Lund University has provided new evidence that aortic valve disease may be preventable. Their findings show that so-called ... key-aortic-valve-disease-prevention-lowering-cholesterol-early More in Medicine & Health. * Body size may influence womens ... A key to aortic valve disease prevention: Lowering cholesterol early. Montreal, Sunday 26, 2014 - An international research ...
Aortic Disease. Previous: Aortic Arch Aneurysm Repairs Next: Thoracic Endovascular Repair First for Extensive Aortic Disease: ... Valve Disease Aortic Disease Hypertrophic Obstructive Cardiomyopathy Congenital Heart Disease Pericardial Disease Heart Failure ... Descending Thoracic Aortic Disease * Thoracic Endovascular Repair First for Extensive Aortic Disease: The Staged Hybrid ... Previous: Aortic Arch Aneurysm Repairs Next: Thoracic Endovascular Repair First for Extensive Aortic Disease: The Staged Hybrid ...
Heart Valve Diseases. Aortic Valve Stenosis. Heart Diseases. Cardiovascular Diseases. Ventricular Outflow Obstruction. ... such as aortic aneurysms, aortic dissections or valve disease. Patients may not be included if they are less than 18 years old ... Genetic Risks for Bicuspid Aortic Valve Disease. The safety and scientific validity of this study is the responsibility of the ... Aortic valve replacement surgery [ Time Frame: 10 years ]. Secondary Outcome Measures : *Aortic enlargement [ Time Frame: 10 ...
A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT). *Aortic Aneurysm ... Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / ...
  • If the valve is abnormally narrow (aortic stenosis), the heart must work harder for a sufficient amount of blood to be pumped with each beat. (
  • Aortic stenosis refers to the process of thickening and stiffening in the valve. (
  • In aortic stenosis, the aortic valve becomes narrowed and blocked by hard, calcified deposits, or in some people, from rheumatic fever years earlier. (
  • Many elderly people with aortic stenosis remain free of symptoms. (
  • Limitations on strenuous activity (especially lifting heavy objects) are recommended, particularly for those with aortic stenosis. (
  • Aortic stenosis , when the aortic valve cannot open all the way. (
  • The evolving epidemiology of valvular aortic stenosis. (
  • Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group," Circulation , vol. 124, no. 16, pp. 1783-1791, 2011. (
  • I had a double cath on 8/7 which showed a severe aortic stenosis, as well as a twisted stent (I have 7 of them) in a vessel. (
  • There are two types of aortic valve disease - aortic regurgitation and aortic stenosis. (
  • If you suffer from aortic stenosis, an increased burden is placed on your heart, which may weaken the heart muscle and affect your health. (
  • Severe aortic valve stenosis prevents your aortic valve leaflets from opening and closing properly (pictured below). (
  • Hear from Brenda, a patient with severe aortic stenosis. (
  • Aortic valve disease occurs when stenosis , regurgitation or, in really unlucky people, both cause the aortic valve not to work properly. (
  • Your aortic valve isn't the only one that can be diagnosed with stenosis or regurgitation, but it's the one that matters in aortic valve disease. (
  • An aortic valve that started off too narrow from birth also can lead to stenosis (called congenital aortic valve disease ). (
  • EH: Aortic stenosis happens in two groups of patients. (
  • More than one in eight patients aged 75 and older have moderate to severe aortic valve stenosis. (
  • EH: Our aortic valve team guarantees any patient referred by a doctor will be seen by an aortic stenosis expert within 24 hours and will get expert and timely treatment. (
  • Currently, it is estimated that most cases of aortic stenosis in patients less than 65 years old are caused by BAVs. (
  • In a study of 5.4 million adults in the UK, published in the European Heart Journal [1] today (Thursday), researchers found that above a systolic blood pressure [2] of 115 mmHg, every additional 20 mmHg was associated with a 41% higher risk of aortic stenosis (AS) and a 38% higher risk of aortic regurgitation (AR) later in life. (
  • Long-term exposure to higher blood pressure is a strong and potentially modifiable risk factor for aortic stenosis and regurgitation at every level of typical blood pressure, not only in those who are classified as having hypertension. (
  • Researchers from The George Institute for Global Health at the University of Oxford have found that while having high cholesterol levels does not influence your risk of aortic or mitral valve regurgitation, it does increase your risk of developing another major heart valve disease - aortic stenosis. (
  • Aortic stenosis is the most common form of heart valve disease in developed countries and is thought to affect 2-7% of those over the age of 65. (
  • Researchers were therefore able to categorise the study population by genetically-determined cholesterol level and then directly compare outcomes in terms of onset of aortic stenosis. (
  • Until recently, aortic stenosis has been widely considered a degenerative disorder associated with ageing with no recommended medical guidance for its prevention. (
  • Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: 'Aortic stenosis is the narrowing of the aortic valve, the 'door' between the main pumping chamber of the heart - the left ventricle - and the body's main blood vessel - the aorta. (
  • Crucially, the evidence that high cholesterol is a risk factor for aortic stenosis presents clinicians with an opportunity to modify disease risk via preventative measures, for instance through the use of cholesterol-lowering medications such as statin therapy. (
  • Aortic stenosis: a new face for an old disease. (
  • Percentage of left ventricular stroke work loss: a simple hemodynamic concept for estimation of severity in valvular aortic stenosis. (
  • Diastolic dysfunction in aortic stenosis. (
  • Reduced left ventricular myocardial blood flow per unit mass in aortic stenosis. (
  • A mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. (
  • Why angina in aortic stenosis with normal coronary arteriograms? (
  • Physiologic changes with maximal exercise in asymptomatic valvular aortic stenosis assessed by Doppler echocardiography. (
  • Prediction of the severity of aortic stenosis by Doppler aortic valve area determination: prospective Doppler-catheterization correlation in 100 patients. (
  • Usefulness of dobutamine echocardiography in distinguishing severe from non severe valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. (
  • Takeda S, Rimington H, Chambers J. The relation between transaortic pressure difference and flow during dobutamine stress echocardiography in patients with aortic stenosis. (
  • Patients with stenosis often have a small aortic annulus and severe post-stenotic aortic dilation. (
  • I have a bicuspid valve which since birth had aortic stenosis and I am at this point losing weight by diet and mild execrcise. (
  • Subvalvular aortic stenosis (SAS), the most common congenital heart disease in Golden Retrievers, Newfoundlands and Rottweilers, is a troublesome disease. (
  • It is divided, on a functional basis, into aortic sclerosis, in which the leaflets do not obstruct left ventricular outflow, and aortic stenosis, in which obstruction to left ventricular outflow is present. (
  • 2 Aortic stenosis is present in 2% to 5% of very elderly patients, 1,3 is the second most common indication for cardiac surgery, 4 and carries an 80% 5-year risk of progression to heart failure, valve replacement, or death. (
  • People with aortic stenosis (narrowing of the aortic valve) can have no symptoms for a long period of time. (
  • While medication and lifestyle choices can help slow the progress of aortic stenosis, valve repair or replacement remains the only definitive treatment. (
  • Introduction: Aortic stenosis (AS) is the most common hemodynamic significant valvular heart disease and affects about 2% of the population. (
  • Evaluation of AVS can be performed with Doppler echocardiography, and its presence can result in aortic valve stenosis, which is reflected by increased aortic systolic velocities 1 - 4 . (
  • In November 2011, the U.S. Food and Drug Administration (FDA) approved a new treatment for heart patients with severe aortic valve stenosis who are not good candidates for open-heart valve replacement surgery. (
  • Aortic stenosis (AS) is the most common valve disease among the adult population, in the majority of the cases it only requires treatment in advanced age. (
  • Transcatheter aortic valve implantation (TAVI) has become available as an alternative treatment for very high risk or even inoperative patients who are suffering from symptomatic aortic stenosis. (
  • Aortic stenosis happens when your aortic valve does not open all the way causing pressure to build in the left ventricle. (
  • Consuming calcium by drinking calcium-rich drinks or taking calcium supplements does not increase the risk of aortic stenosis. (
  • Today rheumatic fever is rare in the United States, but an older adult that had the fever as a child may be at higher risk of developing aortic stenosis. (
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Subvalvular aortic stenosis. (
  • We summarise the natural history and pathophysiology of aortic stenosis and regurgitation, the indications for surgery, the advantages and disadvantages of tissue, mechanical, homograft and autograft aortic valve replacement, and the prediction of operative mortality for individual patients. (
  • Hemodynamic measurements are a crucial component of diagnosing patients with aortic stenosis and evaluating their need for valve replacement surgery. (
  • Dr. Rick Stouffer, Professor of Medicine and Cardiology at the University of North Carolina School of Medicine, underscores the value of hemodynamics in managing aortic stenosis, distinguishing critical disease from low-gradient or pseudo-aortic stenosis and cardiac dysfunction. (
  • Valvar aortic stenosis is a spectrum, with significant valve obstruction treated in infancy or childhood. (
  • The other end of the spectrum is mild stenosis or commonly just a bicuspid aortic valve. (
  • As aortic stenosis can be progressive, even mild stenosis should be followed regularly until adulthood. (
  • For infants, the most common treatment of valvar aortic stenosis is a balloon valvuloplasty, in which the narrowed aortic valve is relieved by the inflation of a balloon. (
  • Moderate aortic insufficiency, especially if some degree of stenosis persists, is poorly tolerated by the left ventricle and will likely result in aortic valve replacement. (
  • In Discrete Subvalvar Aortic Stenosis (DSVAS), a fibrous ridge obstructs the outflow tract from the left ventricle into the aorta. (
  • When aortic insufficiency develops most cardiologists recommend surgical removal of the sub-valvular stenosis in order to halt any further progression of the aortic insufficiency. (
  • In this form of aortic stenosis, an hour glass-like narrowing or, less frequently, a more irregular narrowing, exist in the aorta above the aortic valve. (
  • We have entered a new era in understanding degenerative aortic stenosis in elderly patients. (
  • With the aging of the US population and the progressive decrease in coronary heart disease prevalence in the past 50 years, aortic stenosis has become a major cardiac concern. (
  • A new classification of aortic stenosis recognizes 4 categories based on flow state (normal or low) and valve gradient (high or low). (
  • Aortic stenosis (AS) is the most common cardiac valve disease in the United States. (
  • The response of the left ventricle is key to understanding the progression to severe, symptomatic aortic stenosis. (
  • Stöbe, S. / "Pure" severe aortic stenosis without concomitant valvular heart diseases : echocardiographic and pathophysiological features . (
  • Severe calcific aortic stenosis is relatively common, and unless treated with valve replacement it carries an adverse prognosis. (
  • Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, is a new therapeutic modality for treatment of older patients with severe symptomatic aortic stenosis and other comorbidities, who have an inherently high surgical risk. (
  • The initial success rates have led to a rapid adoption of this technique in clinical practice in high-risk patients with severe symptomatic aortic stenosis. (
  • Over the years, growing evidence has indicated the risk factors for calcific aortic stenosis including lipids, hypertension, male gender, renal failure, and diabetes. (
  • They can involve the ascending aorta, aortic arch, thoracic descending aorta, and/or abdominal descending aorta. (
  • A thoracic aortic aneurysm involves the ascending aorta, arch, or descending aorta. (
  • Also referred to as transcatheter aortic valve implantation (TAVI), is a procedure that replaces your diseased aortic valve with a man-made valve. (
  • Aortic Valve Replacement-The surgeon accesses the diseased aortic valve through an incision in the sternum. (
  • This new procedure, called transcatheter valve replacement (TAVR), replaces the diseased aortic valve through a tube that is placed in the patient's leg, or through an incision in the chest that is much smaller than traditional surgery. (
  • On the other hand, if the valve does not close properly, it may cause aortic regurgitation because some of the blood being pumped out into the aorta regurgitates, or leaks backward, into the left ventricle with each beat. (
  • Aortic regurgitation is usually asymptomatic until middle age. (
  • Some causes of aortic regurgitation include congenitally bicuspid (only two cusps instead of three) valves, infective endocarditis, and high blood pressure. (
  • Aortic insufficiency , or aortic valve regurgitation, in which your aortic valve doesn't close tightly enough. (
  • Aortic valve regurgitation, or aortic insufficiency, occurs when the aortic valve does not close tightly. (
  • Colour Doppler echocardiography showed severe aortic regurgitation, a pressure gradient over the aortic valve (maximum pressure gradient 38 mm Hg, mean gradient 24 mm Hg), and diastolic back flow in the abdominal aorta. (
  • People with aortic valve defects can have a variety of symptoms depending on whether blood is leaking into the heart (aortic regurgitation) or blood is restricted from passing into the aorta. (
  • Long-term experience of surgical treatment for aortic regurgitation attributable to Behçet's disease. (
  • In this article, clinical data and surgical outcomes in patients with aortic regurgitation attributable to Behçet's disease were analyzed. (
  • METHODS: Nineteen patients with aortic regurgitation attributable to Behçet's disease were surgically treated between March 1986 and June 2008. (
  • All deaths occurred after second operations, and the causes of death were low cardiac output (n = 6) and sudden aggravation of aortic regurgitation (n = 3). (
  • Naidu Otikunta, A. , Reddy, Y. , Polamuri, P. and Srinivas, R. (2016) Common Complication in an Uncommon Disease: Presence of Aortic Regurgitation in Patient with Quadricuspid Aortic Valve. (
  • We present a case of QAV with moderate aortic regurgitation (AR) and left ventricular hypertrophy without ventricular dysfunction, managed conservatively and is followed up since 3 years without any further complications. (
  • Figure 2 depicts transthoracic color Doppler echocardiography showing QAV with moderate aortic regurgitation. (
  • Even for patients who are treated with the valvotomy only, an aortic valve replacement is ultimately often necessary because of calcification or valve regurgitation. (
  • Additional monitoring tools, such as molecular imaging, could improve risk stratification, while assessment of severity and prognosis of patients with chronic aortic regurgitation, is desirable. (
  • The CVI's Structural Heart Center offers a wide variety of surgical, nonsurgical and hybrid procedures to treat aortic valve disease. (
  • Depending on the severity of disease, your treatment options may include lifestyle changes, medicines and surgical medical procedures. (
  • 1 Although great strides have been achieved during the past years in the management of patients with thoracic aortic aneurysm by new surgical techniques, postoperative mortality and morbidity rates still remain high. (
  • Patients with bicuspid or unicuspid aortic valves, regardless of surgical status. (
  • A total of 24 patients with aortic valvular disease associated with congenital bicuspid aortic valve underwent surgical treatment at our institution during the period from January, 1997 to December, 1999. (
  • These 24 patients constituted 46.2% (24/52) of all cases of surgical operations for aortic valvular disease. (
  • New therapeutic strategies such as endovascular treatment and surgical techniques have appeared to improve conventional surgery in advanced phases of the disease, but until recently, medical treatment has focused on the control of cardiovascular risk factors using beta-blockers to reduce aortic wall stress by reducing blood pressure and heart rate. (
  • Surgical management of aortic disease. (
  • This study was designed to evaluate the optimal surgical treatment strategy for abdominal aortic aneurysm (AAA) coexisting with coronary artery disease (CAD). (
  • 5 Though the disease is associated with substantial clinical consequences, there currently is no effective therapy for the disease other than surgical aortic valve replacement. (
  • Ten years experience of thoracic and thoracoabdominal aortic aneurysm surgical repair: lessons learn. (
  • Thus any preventive or surgical strategy must recognize the aortic disease in its entirety. (
  • She underwent surgical replacement of her aortic valve with a Medtronic Hall prosthetic valve No 21. (
  • We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. (
  • Identification of aneurysm-predisposing susceptibility genes may lead to gene-directed surgical therapy of the ascending aorta for patients with bicuspid aortic valves. (
  • The mortality of thoracic aortic diseases (mainly aneurysms and dissections) is high, even with surgical treatment. (
  • This two-and-a-half day live symposium will be the thirteenth in an annual series and will be designed to present and discuss the diagnosis and treatment paradigms for aortic diseases, including medical, endovascular, surgical, and hybrid options. (
  • We offer both minimally invasive and open surgical procedures for our aortic disease treatments . (
  • A great majority of quadricuspid aortic valves do not have a normal function and often necessitate surgical treatment. (
  • The surgical procedure entailed complete endoprosthesis removal, closure of the aortic stump below the renal arteries with polypropylene sutures, and omentum coverage. (
  • Surgical aortic valve replacement (SAVR) is very often refused because of advanced age and poor general condition. (
  • If thoracic aortic disease can be detected early and managed, it gives us the opportunity to select patients for surgical or endovascular repair when the patient is stable," said Loren F. Hiratzka, M.D., who chaired the guidelines writing committee and is the medical director of cardiac surgery for TriHealth, Inc. (Bethesda North and Good Samaritan Hospitals) in Cincinnati, OH. (
  • This surgical repair replaces the aortic valve with the patient's own pulmonary valve and then replacing the pulmonary valve with a human donated valve (the Ross repair shown in the animation). (
  • Surgical treatment was indicated to replace the aortic root using a composite prosthesis and Bentall and De Bono coronary reconstruction. (
  • Because AS plays such a prominent role in cardiovascular care, there is a renewed interest in several aspects of the disease, including understanding the pathophysiologic processes, predicting adverse cardiac events accurately, diagnosing severe disease, and indicating cardiac surgical procedures. (
  • Surgical treatment involves the tying off and separation of one of the branches of the double aortic arch. (
  • Traditional surgical valve replacement has been the mainstay in the treatment of severe aortic valvular disease, and in the absence of serious comorbidities it is associated with low operative mortality. (
  • This is the first recurrent CNV discovered to be associated with thoracic aortic aneurysms and dissections. (
  • An estimated 8,000 people die annually from thoracic aortic aneurysms and dissections (TAAD). (
  • Researchers found 16p13.1 duplications in eight of 765 patients with non-familial, non-syndrome-related thoracic aortic aneurysms and dissections compared to four patients in 4,569 controls. (
  • Thoracic aortic aneurysms and dissections are familial in up to 20 percent of all cases. (
  • Background: Thoracic aortic aneurysms and dissections (TAAD) have a genetic component with an estimated 20-25% of the patients having a positive family history. (
  • VSMCs of Nos3 −/− mice showed downregulation of 15 genes, of which seven were associated with aortic aneurysms and dissections in the human population. (
  • The most common valvular problem in old age is aortic valve disease. (
  • Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand," International Journal of Cardiology , vol. 169, no. 4, pp. 296-304, 2013. (
  • 2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease. (
  • These findings collectively suggest that AS and AR might be partially preventable with potential implications on clinical practice guidelines for prevention of cardiovascular disease in general and valvular heart disease and hypertension in particular," write the authors of the EHJ paper. (
  • Professor Rahimi said: "The study shows that serious valvular heart diseases that are common at old age are not simply due to aging. (
  • Guidelines on the management of valvular heart disease. (
  • An increase of aortic valvular disease associated with congenital bicuspid aortic valve is observed due to the relative decrease of rheumatic valvular diseases. (
  • Preoperative and intraoperative evaluation is important in cases of aortic valvular disease associated with congenital bicuspid aortic valve. (
  • Valvular disease is rare in patients with JIA 2 and consists of valvulitis with a substrate with non-specific changes of fibrosis and necrosis. (
  • Valvular involvement has been described in patients with all types of JIA, 3 the aortic valve being most commonly affected. (
  • 4- 9 Valvular disease is associated with severe destructive articular disease. (
  • The inclusion criteria for the selection of the sample were all patients undergoing transthoracic Doppler echocardiography during the period mentioned above when the aortic valvular system was evaluated. (
  • Here, we developed a 3D in vitro heart valve model that resembles the morphology of the valvular extracellular matrix and mimics the mechanical and physiological behavior of the aortic valve fibrosa and spongiosa. (
  • The assessment of myocardial function in the context of valvular heart disease remains highly challenging. (
  • This review gathers and summarizes current evidence regarding the use of these techniques to assess myocardial deformation in patients with valvular heart disease. (
  • Aortic dissection occurs when the wall of the aorta bulges so much that the layers of the aortic wall tear. (
  • A break in all three layers of the aortic wall is termed a rupture. (
  • A tearing of the inner lining of the aortic wall, allowing blood to enter and split the layers of the aortic wall. (
  • In aortic rupture, all three layers of the aortic wall burst, resulting in massive bleeding inside the body. (
  • Play media Aortic dissection (AD) occurs when an injury to the innermost layer of the aorta allows blood to flow between the layers of the aortic wall, forcing the layers apart. (
  • Yasbeck said medical professionals misdiagnosed her husband's condition as a heart attack, a common occurrence with aortic dissections. (
  • Patients with thoracic aortic aneurysms that lead to acute aortic dissections are 12 times more likely to have duplications in the DNA in a region of chromosome 16 (16p13.1) than those without the disease, according to a study led by genetic researchers at The University of Texas Health Science Center at Houston (UTHealth). (
  • Usually described as a sudden, sharp, tearing pain in the chest and back, aortic dissections are often mistaken for a heart attack. (
  • A multi-institutional team led by Dianna Milewicz, M.D., Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) has found a recurrent genetic mutation that has been linked to deadly thoracic aortic dissections in family members as young as 17 years of age. (
  • The majority of the affected family members suffered acute aortic dissections at young ages (17 to 51 years). (
  • Using this management protocol, acute aortic dissections and the associated premature deaths can be prevented. (
  • He was also found to have aortic root dilation and because of his family history of early thoracic aortic dissections at diameters smaller than 5 centimeters, he elected to have surgery. (
  • and nephew, 23, all died from thoracic aortic dissections. (
  • BAV patients are also at high risk to develop aneurysms of the ascending aorta, which may lead to aortic dissections. (
  • Patients will also be followed up by telephone or email about once a year to determine if they experience any medical complications related to Bicuspid Aortic Valve (BAV), such as aortic aneurysms, aortic dissections or valve disease. (
  • These are known as thoracic aortic aneurysm (TAA), aortic dissections and aortic ulcerations. (
  • Acute aortic dissections are associated with high mortality and morbidity, even when operated on. (
  • A combination of histological examination and in vivo ultrasound imaging was used to investigate aortic dilation and dissections in Nos3 −/− mice. (
  • Spontaneous aortic dissections were found in ascending aortas located at the sinotubular junction in ∼13% of Nos3 −/− mice. (
  • Anterior chest pain is associated with dissections involving the ascending aorta, while interscapular back pain is associated with descending aortic dissections. (
  • However, roughly 80% of people with bicuspid aortic valves will require valve repair or replacement later in life, often in the late 40s or early 50s (this was the case with Arnold Schwartzenegger). (
  • Thoracic aortic aneurysms may be related to hypertension, bicuspid aortic valves, inflammatory conditions, trauma or an underlying genetic disorder, such as Marfan syndrome , Loeys-Dietz aneurysm syndrome , Turner syndrome, familial thoracic aortic aneurysm and dissection syndrome , and vascular Ehlers-Danlos syndromes. (
  • We hypothesize that genotypic variations in patients with bicuspid aortic valves contribute to this observed variability in aortic phenotype. (
  • Results were compared with control subjects with trileaflet aortic valves (n = 94), bicuspid aortic valves, and normal aortas (n = 22) and in subjects with tricuspid aortic valves and thoracic aortic aneurysms (n = 28). (
  • RESULTS: Four unique, nonsynonymous (3 novel) variants were identified in 5 (10.4%) of 48 patients with concomitant bicuspid aortic valves and thoracic aortic aneurysms compared with only 3 (2.1%) of 144 control subjects (P = .02). (
  • Of these, 2 novel missense mutations, A1343V and P1390T, were observed only in patients with bicuspid aortic valves and tricuspid aortic aneurysms. (
  • CONCLUSIONS: This targeted analysis involving NOTCH1 exons previously implicated in familial and sporadic bicuspid aortic valve demonstrates overrepresentation of NOTCH1 missense variants among patients with bicuspid aortic valves and thoracic aortic aneurysms. (
  • The study compared the outcomes of 13,205 patients-2,079 with bicuspid aortic valves and 73 with Marfan syndrome-who had AVR replacement between 1995 and 2010. (
  • Loyola's cardiology and heart surgery program is nationally recognized for our diagnosis and treatment of aortic conditions. (
  • Aortic disorders often require a team approach to diagnosis. (
  • A diagnosis of aortic valve disease means your aortic valve doesn't work properly. (
  • Diseases of the thoracic aorta represent often life-threatening conditions, and despite growing consciousness among the physicians about the role of early diagnosis in determining the appropriate treatment, they are still far from holding precise guidelines in management of acute and chronic aortic syndromes. (
  • From March 1999 to October 2003, 132 consecutive patients (113 male and 19 female) were admitted with clinical and instrumental diagnosis of either acute (44) or chronic (88) aortic disease. (
  • Others have normal valves at birth but develop valve disease due to rheumatic fever - an inadequately treated strep infection that affects the heart, which, fortunately, is much less common today because of advances in the diagnosis and treatment of strep throat (and why it's important when treating strep to take the full course of the prescribed antibiotic even if symptoms have abated). (
  • This book is driven by the considerable progress made by novel imaging techniques in understanding the pathophysiology and evolution of aortic disease and its diagnosis. (
  • The diagnosis aortic valve insufficiency and secondary angina pectoris was made. (
  • Doctors can often diagnosis aortic valve disease during a physical examination. (
  • Learn more about aortic disease diagnosis and aortic disease treatments available at Henry Ford. (
  • Two-dimensional (2D) echocardiography showed enlarged left ventricle and established the diagnosis of quadricuspid aortic valve. (
  • Aortic diseases need excellent radiological and interventional facilities for early diagnosis and further treatment planning. (
  • The Amrita Centre for Aortic Diseases has the latest 256 slice high-definition CT scanners and 3T MRI machines for aortic imaging, diagnosis and planning of complex aortic interventions. (
  • Now, new clinical guidelines spearheaded by the American College of Cardiology (ACC) and the American Heart Association (AHA) not only offer new recommendations for the diagnosis and management of thoracic aortic disease (TAD), they deliver a powerful message to physicians and patients: Early diagnosis and treatment can save lives. (
  • Recent scientific and clinical advances drove the development of guidelines to aid physicians in the diagnosis and management of aortic dissection, aortic aneurysm and other forms of TAD, said Kim A. Eagle, M.D., director of the University of Michigan Cardiovascular Center in Ann Arbor and co-author of the guidelines. (
  • Therefore, cells mechanical properties can be used as a marker for the early diagnosis of pathologies as cancer or cardiovascular diseases. (
  • Women with symptoms of aortic aneurysm will need an imaging test to confirm the diagnosis and determine the best treatment. (
  • Complementary studies (chest x-ray, electrocardiogram, angiography, tomography, and echocardiogram) were performed, obtaining a diagnosis of Stanford type A ascending aortic dissection. (
  • You may remember from school that the heart has four valves, two of which rarely cause trouble (the pulmonary and the tricuspid), and two of which are more frequently in need of replacement (the mitral and the aortic). (
  • We performed aortic valve replacement in 22 patients, aortic root replacement in 1 patient and aortic root remodeling in 1 patient in combination with mitral valve plasty in 3 patients, coronary artery bypass grafting in 3 patients and closure of the atrial septal defect (ASD) in 1 patient. (
  • The specimen is a heart, the left ventricle being laid open to display the cavity and mitral and aortic valves. (
  • The following report presents the case of a 26-year-old man with a history of Marfan syndrome, retrosternal lancinating pain, nausea, vomiting, and medium effort dyspnea that evolved to orthopnea, perioral cyanosis, murmur of aortic insufficiency and mitral systolic murmur. (
  • In patients with aortic and/or mitral valve disease the presence of pulmonary hypertension (PH) indicates a decompensated state of the disease with left ventricular and left atrial dysfunction and exhausted compensatory mechanism, i.e., a state of heart failure. (
  • In the present review we discuss the pathophysiology and clinical impact of PH in patients with aortic and mitral valve disease, the comprehensive non-invasive and invasive diagnostic approach required to define treatment of PH, and recent insights from mechanistic studies, registries and randomized studies, and we provide an outlook regarding gaps in evidence, future clinical challenges, and research opportunities in this setting. (
  • Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to increased GSK-3b-mediated activation of ROCK and induction of a hypercontractile phenotype. (
  • An aortic rupture happens when the aortic wall tears open completely. (
  • If you have an at-risk section of your aortic arch, such as due to an aneurysm (ballooning and weakening of the aortic wall) or dissection (split within the muscle of the aortic wall, placing it at risk of rupture), it may be necessary to reinforce or repair segments of your aorta. (
  • When the aorta enlarges to a certain size, elective surgery can be performed in order to avoid emergency repair to attempt to repair a catastrophic aortic dissection or rupture. (
  • No stent graft-related complications were detected, although only in 1 case, an asymptomatic rupture of the Excluder connecting bar was found with a perforation of the fabric and an intra-aortic exposition of the bar itself. (
  • Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair. (
  • Thoracic aortic disease is serious because weak, fragile aortic tissue under high pressure may tear or rupture, causing life-threatening bleeding. (
  • When the risk of aortic dissection or rupture is greater than that associated with surgery, elective surgery is offered to replace the diseased section of the aorta with a Dacron graft. (
  • Aortic dissection and aortic rupture may be fatal and require emergency care at a center with expertise in the care of patients with these conditions. (
  • Using cocaine, even once, creates the risk of life-threatening aortic dissection or rupture, and can make systolic blood pressure soar. (
  • Abdominal aortic aneurysm (AAA) is a common disease that is life threatening when rupture occurs. (
  • The risk of rupture from aortic dissection is more substantial than from aortic aneurysm. (
  • The results of treatment for stable disease are far better than for acute-and often catastrophic-aortic rupture or dissection. (
  • Patients should tell their physicians not only about close relatives with aortic aneurysm, dissection, or rupture, but also about any family history of unexplained sudden death. (
  • Aortic dissection can quickly lead to death from insufficient blood flow to the heart or complete rupture of the aorta. (
  • It is usually associated with pericardial tamponade, severe aortic insufficiency, or rupture of the aorta. (
  • Optimal pain management after aortic valve implantation: an opportunity to improve outcomes after transapical access in the future? (
  • Transcatheter aortic valve implantation (TAVI) -The surgeon threads a catheter - a long, flexible tube - through an artery, usually in the groin or pelvis. (
  • Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, was first implanted by Andersen in 1993 in a closed chest experimental pig model. (
  • Objectives This study sought to determine the effects of chronic obstructive pulmonary disease (COPD) on clinical outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) and to determine the factors associated with worse outcomes in COPD patients. (
  • An aortic valve disorder usually does not cause any symptoms in its early stages. (
  • Actress Amy Yasbeck wants families to know the symptoms of thoracic aortic disease, which kills an estimated 15,000 to 20,000 people in the United States every year. (
  • Symptoms may vary depending on the type of aortic valve disease you have, and some patients do not have any symptoms. (
  • Symptoms of aortic valve endocarditis may also include flu-like symptoms and blood in the urine. (
  • If you don't have any symptoms of aortic valve disease, or if your symptoms are mild, your doctor may simply monitor your condition on a regular basis, including having you undergo periodic echocardiograms. (
  • Stephen Harris' brother was the first to have symptoms of an aortic dissection when he was 51 years old and was found to have a descending thoracic aortic dissection. (
  • Your medical history, health evaluation, and symptoms could indicate the presence of an aortic disorder. (
  • While these symptoms can be indicative of an aortic disorder, additional tests will be needed definitively diagnose your specific condition. (
  • Without serious symptoms, aortic valve disease may simply require an easygoing lifestyle -- due to the heart's limited ability to deliver oxygenated blood -- and regular cardiology exams. (
  • The disease is characterised by restricted blood flow through the valve, with affected individuals commonly experiencing symptoms such as chest pain, shortness of breath, heart palpitations and, in more severe cases, collapse and loss of consciousness. (
  • For additional information on risks, signs and symptoms, feel free to visit community resource The John Ritter Foundation for Aortic Health . (
  • Aortic diseases often go unnoticed because patients rarely feel any symptoms. (
  • Despite the lack of symptoms in stable conditions, most aortic diseases have a high morbidity and mortality. (
  • Most thoracic aortic aneurysms do not cause symptoms and are not detectable on a routine physical examination. (
  • Success means that the patient resumes a completely independent life without symptoms of disease or consequence of surgery. (
  • It's important to understand and recognize the causes, symptoms, and treatments for these two types of aortic valve disease. (
  • Since the aortic valve regulates the blood flow between the aorta and the left ventricle, this restricted blood flow causes symptoms like shortness of breath, fatigue, and passing out. (
  • In some patients the aortic valve may narrow slightly but they will never have any noticeable symptoms. (
  • Although the wall of the aorta can become dangerously thin, patients with an aortic aneurysm often have no symptoms unless the aneurysm ruptures. (
  • Monarch's tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. (
  • Women with large aortic aneurysms that are causing symptoms need immediate treatment to prevent if from bursting. (
  • You should learn to recognize the symptoms of aortic disease and talk to your doctor if you experience them. (
  • Even if you do not have any symptoms, certain women at high risk for an aortic aneurysm should have a screening test so that it can be diagnosed and treated early. (
  • A medical history and physical examination are the first steps in evaluating women with signs or symptoms of aortic disease. (
  • Women with the classic symptoms of an aortic aneurysm that has ruptured-constant, severe abdominal and/or back pain (sometimes radiating to the groin, buttock, or legs), a pulsing mass in the abdomen, and low blood pressure-should undergo immediate surgery to diagnose and repair the aneurysm. (
  • Although the physical exam can detect signs of a large aneurysm, most aortic aneurysms do not cause any symptoms. (
  • Women being evaluated for aortic disease may also have additional imaging tests (such as a chest X-ray or echocardiogram ) to rule out heart and lung problems that could be causing their symptoms. (
  • Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. (
  • These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease. (
  • Calcific aortic valve disease is identified by thickening and calcification of the aortic valve leaflets in the absence of rheumatic heart disease. (
  • The lack of medical therapies for calcific aortic valve disease can be traced to at least two important issues, one intellectual, the other practical. (
  • The first was the long-held notion that calcific aortic valve disease was a "degenerative," and therefore unmodifiable, condition. (
  • 6 However, more recent studies have demonstrated convincingly that calcific aortic valve lesions have many features characteristic of an active pathobiological process, including chronic inflammation, 7-9 lipoprotein deposition, 10-12 active calcification, 13-18 and renin-angiotensin system activation. (
  • Only very recently has a purported mouse model of calcific aortic valve disease been described. (
  • Nonetheless, through a combination of epidemiological studies, histopathologic evaluation of human lesions, and genetic epidemiology, the past several years have seen rapid advances in our understanding of calcific aortic valve disease pathogenesis. (
  • 37 This review will summarize our current understanding of the pathogenesis of calcific aortic valve disease, attempt to place what currently is known in the context of on-going or recently-completed clinical trials, and identify some areas for future investigation. (
  • Over the past several years, a number of risk factors for calcific aortic valve disease have been identified. (
  • In this talk, we will analyze the mechanical properties of aortic valve interstitial cells (VICs), the predominant constituent of aortic valves, governing ECM structure and composition, in the onset of calcific aortic valve disease (CAVD). (
  • Calcific aortic valve disease is relatively common in the high-income countries, affecting between 4% and 5% of adults above the age of 75 years, and unless corrected, it carries significant morbidity and mortality. (
  • Calcific aortic valve disease is a common disease in the elderly associated with significant morbidity and mortality. (
  • Also, several studies have investigated the role of biomarkers regarding their utility in the screening of calcific aortic valve disease and their putative clinical value, though their role still remains undetermined. (
  • Approximately 20% of thoracic aortic aneurysms are associated with an autosomal pattern of inheritance from a mutation in a single gene, whereas abdominal aortic aneurysms (AAAs) do not typically demonstrate such inheritance but rather seem to present as a polygenic disorder involving variants of weaker effect. (
  • This study aimed to investigate the clinical course of BD patients with abdominal aortic aneurysms (AAA). (
  • To our knowledge, this case is the first illustrated report of typical rheumatoid nodules found in an aortic valve removed owing to aortic valve insufficiency in a patient with polyarticular JIA. (
  • Furthermore, our case report confirms the possibility of successful mechanical aortic valve replacement in a case of severe progressive aortic valve insufficiency and secondary angina pectoris in a patient with polyarticular JIA. (
  • However, because of its proximity to the aortic valve, it can often result in the development of aortic insufficiency. (
  • In 50% of bicuspid can develop aortic dilation. (
  • Some patients with a bicuspid aortic valve may also develop dilation (enlargement) of the aorta. (
  • This study demonstrates that, in addition to congenital BAV formation, disrupted endothelial-mediated nitric oxide (NO) signalling in Nos3 −/− mice also causes aortic dilation and dissection, as a consequence of inhibited elastic fibre formation in VSMCs within the ascending aorta. (
  • In 1990, a third leading cause of embolic stroke was identified on transesophageal echocardiography (TEE), namely severe atherosclerotic plaques in the aortic arch. (
  • All 3 had severe plaque in the aortic arch on TEE. (
  • TEE showing aortic arch with very severe atherosclerotic plaque. (
  • If damage to your aortic valve is severe, surgery may be necessary to repair or replace the valve. (
  • Cheryl Harris, Stephen's wife, said their daughter Jenny was eight months pregnant in 2006 when she began to have severe pain in her back just like her uncle but since aortic disease mostly affects older men, they didn't connect it to her. (
  • EH: The normal treatment for severe aortic valve disease is surgery - we take out the old aortic valve and sew in a new one. (
  • BACKGROUND: Cardiac involvement in Behçet's disease is a rare but severe complication and presents challenges to cardiac surgeons as a result of late valve detachment or pseudoaneurysms of the aortic root after valve surgery. (
  • The gene known as PRKG1 makes a protein called cGMP-dependent kinase, type I. The PRKG1 mutation alters the function of the protein and causes the muscle cells in the wall of the aorta to respond incorrectly to pulsatile blood flow from the heart, and the change in this one protein ultimately causes thoracic aortic aneurysm and acute aortic dissection. (
  • Conclusions- Endovascular treatment of thoracic aortic diseases, even in the acute phase, may represent a valid option with a low mortality rate. (
  • Moreover, we try to search for the real behavior of native aortic wall in response of modifications in the acute and chronic phase induced by aortic disease as well as by introducing a noncompliant system in a semi-compliant structure such as aorta. (
  • Our center also participates in the International Registry of Acute Aortic Dissection and the Valve-Sparing Aortic Root Replacement Registry in Marfan Syndrome. (
  • OBJECTIVES: Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection. (
  • Acute thoracic aortic dissection is caused by a tear in the intimai lining of the aorta, and is a symptom of acute aortic syndrome. (
  • Aortic valve disease can be congenital, result from infection, occur as a result of rheumatic heart disease, result from the processes of aging, or be of unknown origin. (
  • Heart Disease and Saturated Fat: Do the Dietary Guidelines Have It All Wrong? (
  • When aortic dissection is confused with heart disease, it's fatal," Yasbeck told Healthline. (
  • We asked Eric Horlick, a cardiologist and director of structural heart disease intervention at the Peter Munk Cardiac Centre about a new program that ensures patients get prompt, life-saving care. (
  • Laing SP, Swerdlow AJ, Slater SD et al (2003) Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. (
  • Treatment options for heart disease depend on the type of disease you have. (
  • The incidence of rheumatic heart disease has dropped so much in North America that, in my experience, rheumatic AS is rarely seen. (
  • With a nod to tradition, it should be noted that there are 3 forms of AS from the perspective of congenital heart disease. (
  • Anyone with congenital heart disease, repaired or non-repaired, should consult with their cardiologist about physical activity to review the risks. (
  • Abdominal aneurysms are most common form of aortic aneurysm, comprising 75% of cases. (
  • There are three types of aortic aneurysms. (
  • Using a team approach to care, Henry Ford's Multidisciplinary Aorta Program provides advanced care and lifelong management for all types of aortic disorders. (
  • Aortic atherosclerotic lesions have been referred to in several different ways in the medical literature. (
  • The degradative SMC phenotype also worsens atherosclerotic disease and could thus be considered as a therapeutic target for diverse aortic diseases. (
  • Light to moderate alcohol consumption is associated with a lower atherosclerotic burden of aortic plaque. (
  • Blood pressure should be considered as a major risk factor for aortic valve disease, much in the same way as we think of elevated blood pressure as a risk factor for atherosclerotic disease. (
  • We have investigated the presence of the connective-tissue-degrading metalloproteinases in homogenates prepared from atherosclerotic, aneurysmal and control aortic media. (
  • Ulceration of atherosclerotic plaque penetrates into the aortic wall. (
  • The obligate intracellular bacterium Chlamydia pneumoniae (Cp), a common human pathogen, has been associated with atherosclerotic cardiovascular disease. (
  • Diabetes is a risk factor for atherosclerotic disease but negatively associated with the development and progression of abdominal aortic aneurysm (AAA). (
  • This book follows the concept of perceiving the entire aorta as one functional organ assuming that all individual pathologies and local interventional procedures affect the up- and downstream segments with consequences for complications and disease progression. (
  • Our expert team manages the complications of aortic valve disease using the latest advancements in medicine and repairs the valve using both traditional and minimally invasive techniques. (
  • Our Multidisciplinary Aorta Program offers care for a range of aortic disorders helping you avoid life-threatening complications. (
  • Aim: To report a case with quadricuspid aortic valve accompanied with complications. (
  • Patients with Marfan syndrome displayed higher rates of aortic complications in long-term follow-up after aortic valve replacement (AVR) than patients with bicuspid aortic valve disease, according to results of a study published June 1 in the Journal of the American College of Cardiology . (
  • Neurological complications of aortic dissection, such as stroke and paralysis, are due to the involvement of one or more arteries supplying portions of the central nervous system. (
  • Surgeons at UCLA have helped pioneer Transcatheter Aortic Valve Replacement to provide high-risk patients with an option for permanent repair. (
  • For them, we turn to minimally invasive procedures, including the transcatheter aortic valve implant (TAVI). (
  • 9 It was a true 'resurrection' for Cribier and his whole team performing the first TAVI in an inoperable patient in 2002 10 , 11 using a transeptal antegrade approach and balloon-expandable aortic calve prosthesis, while at the same time in the USA, animal studies were being carried out to develop a transapical method of implantation. (
  • Since 2012, TAVI has been performed in more than 50 000 patients worldwide and a number of different aortic prostheses have since been developed. (
  • E. E. Creemers, A. J. Tijsen, and Y. M. Pinto, "Circulating MicroRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? (
  • Gamma-oryzanol has benefits in the treatment of cardiovascular disease. (
  • Prolonged flaxseed flour intake decreased the thickness of the aorta and modulates some modifiable risk factors related to cardiovascular disease in rats. (
  • Rawshani A, Rawshani A, Franzén S et al (2017) Mortality and cardiovascular disease in type 1 and type 2 diabetes. (
  • Prince CT, Secrest AM, Mackey RH, Arena VC, Kingsley LA, Orchard TJ (2010) Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes. (
  • Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease. (
  • Bicuspid aortic valve disease , a congenital defect affecting the aortic valve. (
  • Traditionally, thoracic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in extracellular matrix and loss of smooth muscle cells (SMCs) in the medial layer of the aortic wall. (
  • Curcumin may have a beneficial effect in degenerative aortic aneurysms. (
  • With the bicuspid aortic valve, the eccentric leaflet configuration leads to increased mechanical stress and clinical presentation occurs 2 decades earlier than that of degenerative trileaflet AS. (
  • Aortic Valve Disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. (
  • The aortic valve is one of four valves that control the flow of blood into and out of the heart. (
  • One of these valves, the aortic valve , guards the passageway between the left ventricle and the aorta , your primary supply artery for oxygen-rich blood. (
  • One of the reasons the right side valves are less often involved in disease is because the blood pressure on the right side of the heart is dramatically lower than that on the left. (
  • The relationship between these two pathologies is explained by a progressive release in AVS of oxidized low-density lipoprotein that accumulates in the valves and extend through the coronary ostia towards the arteries where they are deposited, leading to coronary disease. (
  • Here we found that the number of myofibroblasts (correlated to disease-associated phenotype) was similar to the case of healthy valves, and that fibroblasts on CNT matrix resulted in higher stiffness and higher number of focal adhesions, with respect to reference glass. (
  • 1. In a healthy aortic valve , three thin leaflets open and close properly. (
  • Your aortic valve normally has three snugly fitting, triangular leaflets (sometimes called cusps or flaps) attached to a ring of tissue called the annulus . (
  • In the case of Mr. Williams it is possible that he was born with an aortic valve that has two leaflets instead of the normal three, predisposing him to calcification at an earlier age (this is speculation on my part since the details of his case haven't been revealed). (
  • Sometimes, doctors can open a stenotic valve by inserting a catheter with a tiny balloon into the body, pushing it through a vein to the aortic valve and then expanding the balloon, knocking the leaflets fully apart. (
  • Aortic valve sclerosis (AVS) is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. (
  • In addition, people whose aortic valve has only two leaflets (bicuspid valve) instead of the normal three leaflets may be at increased risk for an aortic aneurysm. (
  • Also, the valvuloplasty technique is not very effective in adults whose aortic valve leaflets have become calcified. (
  • Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. (
  • As the largest artery in your body, the aorta is a critical part of your circulatory system and can cause serious heart problems when weakened or torn as a result of high blood pressure, smoking, injuries, connective tissue disorders, congenital conditions like Marfan syndrome, atherosclerosis (the hardening of the arteries due to buildup of fat and cholesterol), and other conditions and diseases. (
  • Certain genetic syndromes that affect connective tissue, including Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome vascular type and Turner syndrome, can greatly increase the risk of developing an aortic aneurysm. (
  • All first-degree relatives (i.e., parents, siblings and children) of those with bicuspid aortic disease, Ehlers-Danlos syndrome, Marfan syndrome and other connective tissue disorders should have a complete aortic checkup. (
  • Other causes include hypertension (high blood pressure), Marfan syndrome (genetic connective tissue disease), infectious diseases such as syphilis or tuberculosis, or possibly a genetic predisposition in the case of abdominal aortic aneurysm. (
  • Risk factors for TAD include poorly controlled high blood pressure, advancing age, male gender, atherosclerosis, inflammatory diseases that damage the blood vessels, and certain genetic conditions that weaken connective tissue, such as Marfan syndrome. (
  • assessed the long-term follow-up of thoracic aortopathy after AVR in patients with bicuspid aortic valve disease and those with Marfan syndrome. (
  • The results of the study showed that patients with Marfan syndrome were 14 times more likely to present with aortic dissection during long-term follow-up and five times more likely to undergo thoracic aortic surgery. (
  • The authors of the study note that these results "provide additional support for the discrete treatment algorithms for patients with bicuspid valve disease," as the operative management of these patients has previously been extrapolated based on Marfan syndrome patients. (
  • AD is more common in those with a history of high blood pressure, a number of connective tissue diseases that affect blood vessel wall strength including Marfan syndrome and Ehlers Danlos syndrome, a bicuspid aortic valve, and previous heart surgery. (
  • Can aortic valve disease be detected early enough to eliminate the need for surgery? (
  • Hybrid aortic surgery combines traditional open-heart surgery and endovascular stent graft procedures. (
  • In October 2012, Anthony Estrera, M.D., associate professor of cardiovascular surgery at the UTHealth Medical School and the Memorial Hermann Heart and Vascular Institute, performed the graft replacement of his aortic root. (
  • I do not have the same problem as you, but have had open heart surgery, aortic valve replacement and took care of my father after his CABG x 5. (
  • Now with news that former First Lady Barbara Bush has undergone open heart surgery to replace her defective valve and that comedian Robin Williams will soon have the same procedure, suddenly the aortic valve is front and center and on everyone's minds. (
  • Aorta and Aortic Valve Surgery - Keyhole Approaches. (
  • Despite the extent of aneurysmal lesions and high frequency of association with visceral and supraaortic vessel lesions, the outcome of surgery in patients presenting with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease was satisfactory. (
  • In our center, a multidisciplinary approach to the evaluation and management of thoracic aortic disease is offered, involving specialists from cardiac and vascular surgery, cardiology, medical genetics and radiology. (
  • When surgery is necessary, the most recent advances in thoracic aortic surgery are available. (
  • We perform more than 200 major aortic procedures each year at NYP/Columbia's Aortic Surgery Program. (
  • He frequently performs coronary artery bypass surgery, aortic valve and aortic root replacement surgery, surgery to correct thoracic aneurysms, heart valve surgery, aortic surgery and heart transplant surgery. (
  • Patients with a history of an aortic aneurysm, aortic surgery or aortic dissection and their family are welcome to attend. (
  • Such patients need to be shifted immediately to centers with expertise in aortic dissection surgery. (
  • Dr. Hans Joachim Schafers, Director, Department of Thoracic & Cardiovascular Surgery, Saarland, University Medical Center, Germany, said that bicuspid aortic valve disease roughly affects 1 to 2% of population. (
  • What Types of Heart Diseases are Treated with Surgery? (
  • Therefore, balloon valvuloplasty remains an emergency option as a bridge to aortic valve surgery. (
  • Although most investigators feel that aortic atherosclerosis is a leading cause of embolic disease, doubts have been raised. (
  • 1 Correlations also were found between elevated levels of lipoprotein(a) [Lp(a)] and low-density lipoprotein cholesterol (LDL) and increased risk of aortic sclerosis, 1 though the relative risks appeared to be lower than those typically reported for atherosclerosis. (
  • Ohyama Y, Ambale-Venkatesh B, Noda C et al (2017) Aortic arch pulse wave velocity assessed by magnetic resonance imaging as a predictor of incident cardiovascular events: the MESA (multi-ethnic study of atherosclerosis). (
  • Aortic aneurysms are believed to be caused by the gradual weakening of the artery due to atherosclerosis, arterial narrowing and hardening from cholesterol plaque build-up. (
  • Associated supraaortic trunks lesions were present in 15 patients (45%) and were treated in 12 patients, including 8 in first-stage procedures prior to thoracoabdominal aortic aneurysm repair. (
  • Direct spinal cord perfusion pressure monitoring in extensive distal aortic aneurysm repair. (
  • Would you,please explain (be specific) what does it mean when on average middle age male patient cardiac mri report is written the following 'There is mild prominence of aortic root which measures 3.9 cm at sinuses of Valsalva.The sinotobular junction is maintained.More distally,the thoracic aorta is normal in size.There is no evidence of dissection. (
  • This Review discusses the latest findings and current theories on the pathogenesis of abdominal aortic aneurysm (AAA) and highlights potential medical therapies for AAA, summarizing previous, ongoing, and potential clinical trials of medical interventions for small AAAs. (
  • The results of this study could affect clinical care because it appears patients with 16p13.1 duplications have an aggressive form of the thoracic aortic disease that causes aneurysms to dissect at smaller diameters," Milewicz said. (
  • 8-10 More recently, the ability to image aortic plaque and its contents has improved significantly through the use of different imaging modalities, and our understanding of the associated clinical syndromes has increased. (
  • Steve Harris traveled to Houston to consult with Milewicz and the clinical team at the Multidisciplinary Aortic and Vascular Disease Clinic. (
  • To be included in the study, patients must have a bicuspid or unicuspid aortic valve, documented by clinical history or imaging studies. (
  • Clinical research in the Aortic Disease Program at the Massachusetts General Hospital Fireman Vascular Center combines leading research with patient care to develop innovative options to treat and prevent aortic disease. (
  • 34-36 Moreover, the era of randomized clinical trials in aortic valve disease has finally begun. (
  • The reader is provided with the most current and comprehensive insight into all fundamental and clinical aspects of aortic disease. (
  • Mr Waterworth has a special clinical interest in aortic valve and root disease, heart valve disease and intrathoracic aortic aneurysms. (
  • Conclusion: Patients with a quadricuspid aortic valve require careful clinical evaluation and close follow up. (
  • Said Dr. Vijayakumar M. , Clinical Professor, Department of Cardiology, Amrita Institute of Medical Sciences, Kochi, "Aortic diseases account for a high number of heart-related deaths and health conditions. (
  • The bicuspid aortic valve is also associated with an aortopathy, in which ascending aortic root dilatation or aneurysm occurs, further complicating this clinical condition. (
  • In particular, the aortic valve controls the flow of oxygenated blood pumped out of the heart from the left ventricle into the aorta, the main artery leading to the rest of the body. (
  • People who have long-term raised blood pressure have an increased risk of aortic valve disease (AVD) - problems with the valve that controls how blood is pumped from the left ventricle of the heart out into the main artery, the aorta. (
  • The thoracic aorta begins where the left ventricle ends at the aortic valve and continues down through the chest. (
  • When it works properly, the aortic valve is a one-way valve that separates the left ventricle, the main pumping chamber of your heart, from your aorta, the main artery that carries oxygenated blood to your entire body. (
  • When the aortic valve won't open all the way because it has narrowed or the cusps have calcified, your heart has to work harder to pump enough blood out of the left ventricle and into your aorta. (
  • New perspectives of the disease now lead us to see the condition in terms of the response of the left ventricle and of systemic features, rather than just in terms of the valve area itself. (
  • New measures of aortic flow and the response of the left ventricle provide new insights into the treatment of patients with this condition. (
  • The foundation urges people with potential genetic risks to get tested for aortic disease. (
  • Previous studies have determined that other types of MYH11 genetic alterations can cause thoracic aortic disease to be inherited in families. (
  • Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. (
  • Some individuals may have a predisposition to develop an aortic aneurysm and/or dissection even without having one of the genetic syndromes. (
  • Several factors increase the risk of developing an aortic aneurysm or dissection, including environmental and genetic influences. (
  • Genetic factors also influence the risk to develop an aortic aneurysm or dissection. (
  • Each confers a high risk for disease, and genetic testing for these genes is now offered clinically. (
  • and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. (
  • 21 Also, an emerging body of literature is investigating how genetic factors might influence disease development. (
  • Some people come to our Multidisciplinary Aorta Program because they have a genetic condition or other medical conditions that put them at greater risk for aortic disease. (
  • Routine screening and genetic testing of the relatives of patients suffering from aortic diseases could save lives, new research has shown. (
  • A research team led by the University of Leicester has published a new study in the Journal of the American Heart Association which shows that over 30% of relatives of patients suffering from thoracic aortic diseases (TAD) have an underlying genetic predisposition to developing an aortic disease themselves. (
  • The study, which is part-funded by the British Heart Foundation, highlights the importance of routine imaging and genetic testing of relatives of patients affected by TAD in order to identify the diseases early. (
  • This research shows that there is a significant cohort of up to 30% of patients, including many younger patients, in whom a genetic predisposition to Aortic Dissection can and should be detected through appropriate screening. (
  • These patients need not only the management of their aortic condition but also comprehensive treatment by genetic specialists and ophthalmologists. (
  • Many genetic syndromes in children may be associated with aortic problems. (
  • This with genetic diseases like Marfan's, increasing incidence of hypertension, inflammatory disorders we are looking into an enormous number of potential patients in society which requires centers of excellence for treatment. (
  • In an accompanying editorial comment , Himanshu J. Patel, MD, FACC, writes that "the fundamental lack of knowledge regarding bicuspid aortic valve disease suggests that there is a need for a prospectively-collected, clinically-robust database to further evaluate the natural history and genetic underpinnings of this complex, heterogeneous pathology. (
  • These are diseases that can be inherited via a Mendelian genetic mechanism. (
  • Recent studies have shown perindopril to be powerful in controlling and even reversing aortic root dilatation. (
  • In March 2014, a formerly healthy 60-year-old man underwent an elective endovascular aortic repair because of an infrarenal aortic aneurysm. (
  • Ritter died at the age of 54 on September 11, 2003 from an undiagnosed aortic dissection. (
  • Descending thoracic and thoracoabdominal aortic aneurysm in patients with Takayasu's disease. (
  • From June 1974 to December 2001 we performed operative treatment on 33 patients with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease. (
  • The aortic valve is thickened and irregular and shows calcification and fusion of the cusps. (
  • Even though the etiological mechanisms of the aortic valve disease and the coronary disease have been documented for many years, the relationship between these two pathological entities only started to be more sharply investigated in the beginning of the 90s after observations, conducted mainly with radiological images, of calcification in the coronary vasculature and in the aortic valve 7 , 8 . (
  • In this issue of the JCI, Li and colleagues introduce an unconventional concept by demonstrating that mTOR-dependent proliferative SMCs render the aortic wall vulnerable to dilatation and dissection rather than prevent disease progression. (
  • Prior research has suggested a link between LDL-C and aortic valve disease but randomized trials of cholesterol lowering performed in patients with advanced disease did not show any benefit in slowing the progression of valve disease," explains first author, Dr. J. Gustav Smith from the Department of Cardiology at Lund University. (
  • Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression. (
  • Mechanisms of action for non-coding RNAs during disease development and progression. (
  • Diabetes is negatively associated with progression of abdominal aortic aneurysm (AAA). (
  • Patients with diabetes and AAA disease might have decreased AAA progression if they switch to another oral antidiabetic or insulin. (
  • The Barnes-Jewish & Washington University Heart & Vascular Center offers specialized care for patients with thoracic aortic diseases. (
  • Dr Giovanni Mariscalco, Associate Professor from the University of Leicester and Honorary Consultant Cardiothoracic Surgeon at Leicester's Hospitals, who led the study, said: "Our research identifies important knowledge gaps with respect to the predictive accuracy of commonly used screening tests across patients with thoracic aortic diseases. (
  • In thoracic aortic disease, the wall of the aorta, the main blood vessel leading out of the heart, weakens and forms an aneurysm that can ultimately lead to an aortic dissection and death. (
  • Thoracic aortic aneurysms - bulges in the wall of the aorta - are more common than doctors had previously thought. (
  • Bleeding within the wall of the aorta, a variation of classic aortic dissection. (