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Enhanced intra-operative grading of ascending aorta atheroma by epiaortic ultrasound vs echocardiography -ORCA

Acute Aortic Syndromes: New Insights From IRAD and GenTAC Registries | Circulation

Acute aortic syndromes: A second look at dual-phase CT<...

Aortic diseases | Article about Aortic diseases by The Free Dictionary

Acute aortic syndrome - Wikipedia

Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis | stroke2prevent

Lack of association between Chlamydia pneumoniaeseropositivity and aortic atherosclerotic plaques | JACC: Journal of the...

Aortic Diseases Support Group - University of Ottawa Heart Institute

Aortic Disease Diagnosis Overview - Peripheral Vascular Disease - tests-diagnosis - Heart Healthy Women

Abdominal aortic atherosclerosis - RightDiagnosis.com

Browsing School of Medicine by Subject Aortic Diseases/etiology/metabolism/pathology

Disease of the Aorta - PVD - cardiovascular-disease - Heart Healthy Women

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Aortic Disease & Genetics | Hoag Heart & Vascular Institute

Endovascular therapy in patients with genetically triggered thoracic aortic disease: applications and short- and mid-term...

STATdx - Penetrating Atherosclerotic Ulcer

Endovascular Treatment of Thoracic Aortic Disease | Circulation

International Heterogeneity in Diagnostic Frequency and Clinical Outcomes of Ascending Aortic Intramural Hematoma<...

Endovascular repair of infrarenal penetrating aortic ulcers: a single-center experience in 20 patients.

Surgical treatment of aortobronchial fistula after thoracic endograft failure | Journal of Cardiothoracic Surgery | Peer review

Different infarction patterns in patients with aortic atheroma compared to those with cardioembolism or large artery...

BJCVS, Vol.: 32 Ed.: 5 - 361/366 - 2017, Hybrid Approach of Aortic Diseases: Zone 1 Delivery and Volumetric Analysis on...

Detection of Aortic Arch Calcification in Apolipoprotein E-Null Mice Using Carbon Nanotube-Based Micro-CT System | Journal of...

Defining best practice for thoracic aortic disease | Heart

Utility of Clinical Examination in the Noninvasive Prediction of Aortic Atheroma - A Prospective Study - Full Text View -...

Meta-analysis of the Diagnostic Accuracy of Transesophageal Echocardiography for Assessment of Atherosclerosis in the Ascending...

DI-fusion Penetrating atherosclerotic ulcer of the descending thoracic...

Chapter 248. Diseases of the Aorta | Harrisons Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical

Heart Care for you | Bangalore | India | Heart Diseases | Aortic diseases | Cardiac surgery | Heart Surgery

Acute aortic syndrome - thoracic and abdominal aorta intramural hematoma in 78 year old male | Szymczyk | Folia Cardiologica

Preoperative Noncontrast Chest Computed Tomography Identifies Potential Aortic Emboli<...

Descending Thoracic Aortic Disease Outcomes | Cleveland Clinic

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Plus it

Search of: diabetes AND heart disease | Recruiting, Not yet recruiting, Available Studies | NIH, U.S. Fed - List Results -...

Cardiovascular Imaging - Apollo Hospitals

Abdominal aortic calcifications predict survival in peritoneal dialysis patients - Research Portal, Aalborg University

Transesophageal echocardiography in the diagnosis of diseases of the thoracic aorta: Part 1. Aortic dissection, aortic...

Aortic calcification and aneurysm in Moscow Lung Cancer Screening. - RadiologyStudy

Aortoiliac occlusive disease<...

EURORAD - Radiologic Teaching Files

Re: Aortic Root Dilation - Heart Disease - MedHelp

Knitted dacron grafts used for abdominal aortic reconstruction: sizing references. - Semantic Scholar

Severe coronary luminal narrowing ascribed to aortic intramural haematoma after valve surgery | Heart

Anesthesia for open abdominal aortic surgery

Comparison of different MRI techniques for the assessment of thoracic aortic pathology: 3D contrast enhanced MR angiography,...

Aortic root dilation - Heart & Cardiovascular Disease - HealingWell.com Forum

Ultrasonographic images of spontaneous intramural hematomas of the intestinal wall in two patients with congenital bleeding...

Case of intramural hematoma of the small intestine caused by anticoagulants]. - Semantic Scholar

Dr Lyn Jones - School of Social and Community Medicine publications

List of variants in gene FBN3 reported as uncertain significance for aortic disease - ClinVar Miner

Dual-slice helical CT of the thoracic aorta.

Aortic plaque distribution in relation to cross-clamp and cannulation procedures during cardiac surgery

Cardiothoracic Surgery Clinic | Baylor Medicine

Aortic atheromas in stroke subgroups detected by multidetector computed tomographic angiography | AVESİS

UTHealth discoveries shed more light on deadly thoracic aort... ( HOUSTON (Nov. 18 2010) Discovery o...)

Patent US6589206 - Methods and devices for occluding the ascending aorta and maintaining ... - Google Patents

Transesophageal magnetic resonance imaging of the aortic arch and descending thoracic aorta in patients with aortic...

Aortic Msx2-Wnt Calcification Cascade Is Regulated by TNF-α-Dependent Signals in Diabetic Ldlr−/− Mice | Arteriosclerosis,...

Mondor's disease

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Stenosis75

• If the valve is abnormally narrow (aortic stenosis), the heart must work harder for a sufficient amount of blood to be pumped with each beat. (healthcentral.com)
• Aortic stenosis refers to the process of thickening and stiffening in the valve. (healthcentral.com)
• In aortic stenosis, the aortic valve becomes narrowed and blocked by hard, calcified deposits, or in some people, from rheumatic fever years earlier. (healthcentral.com)
• Many elderly people with aortic stenosis remain free of symptoms. (healthcentral.com)
• Limitations on strenuous activity (especially lifting heavy objects) are recommended, particularly for those with aortic stenosis. (healthcentral.com)
• Aortic stenosis , when the aortic valve cannot open all the way. (bidmc.org)
• The evolving epidemiology of valvular aortic stenosis. (bmj.com)
• Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group," Circulation , vol. 124, no. 16, pp. 1783-1791, 2011. (hindawi.com)
• I had a double cath on 8/7 which showed a severe aortic stenosis, as well as a twisted stent (I have 7 of them) in a vessel. (healingwell.com)
• There are two types of aortic valve disease - aortic regurgitation and aortic stenosis. (medtronic.com)
• If you suffer from aortic stenosis, an increased burden is placed on your heart, which may weaken the heart muscle and affect your health. (medtronic.com)
• Severe aortic valve stenosis prevents your aortic valve leaflets from opening and closing properly (pictured below). (medtronic.com)
• Hear from Brenda, a patient with severe aortic stenosis. (medtronic.com)
• Aortic valve disease occurs when stenosis , regurgitation or, in really unlucky people, both cause the aortic valve not to work properly. (howstuffworks.com)
• Your aortic valve isn't the only one that can be diagnosed with stenosis or regurgitation, but it's the one that matters in aortic valve disease. (howstuffworks.com)
• An aortic valve that started off too narrow from birth also can lead to stenosis (called congenital aortic valve disease ). (howstuffworks.com)
• EH: Aortic stenosis happens in two groups of patients. (thestar.com)
• More than one in eight patients aged 75 and older have moderate to severe aortic valve stenosis. (thestar.com)
• EH: Our aortic valve team guarantees any patient referred by a doctor will be seen by an aortic stenosis expert within 24 hours and will get expert and timely treatment. (thestar.com)
• Currently, it is estimated that most cases of aortic stenosis in patients less than 65 years old are caused by BAVs. (clinicaltrials.gov)
• In a study of 5.4 million adults in the UK, published in the European Heart Journal [1] today (Thursday), researchers found that above a systolic blood pressure [2] of 115 mmHg, every additional 20 mmHg was associated with a 41% higher risk of aortic stenosis (AS) and a 38% higher risk of aortic regurgitation (AR) later in life. (eurekalert.org)
• Long-term exposure to higher blood pressure is a strong and potentially modifiable risk factor for aortic stenosis and regurgitation at every level of typical blood pressure, not only in those who are classified as having hypertension. (eurekalert.org)
• Researchers from The George Institute for Global Health at the University of Oxford have found that while having high cholesterol levels does not influence your risk of aortic or mitral valve regurgitation, it does increase your risk of developing another major heart valve disease - aortic stenosis. (ox.ac.uk)
• Aortic stenosis is the most common form of heart valve disease in developed countries and is thought to affect 2-7% of those over the age of 65. (ox.ac.uk)
• Researchers were therefore able to categorise the study population by genetically-determined cholesterol level and then directly compare outcomes in terms of onset of aortic stenosis. (ox.ac.uk)
• Until recently, aortic stenosis has been widely considered a degenerative disorder associated with ageing with no recommended medical guidance for its prevention. (ox.ac.uk)
• Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: 'Aortic stenosis is the narrowing of the aortic valve, the 'door' between the main pumping chamber of the heart - the left ventricle - and the body's main blood vessel - the aorta. (ox.ac.uk)
• Crucially, the evidence that high cholesterol is a risk factor for aortic stenosis presents clinicians with an opportunity to modify disease risk via preventative measures, for instance through the use of cholesterol-lowering medications such as statin therapy. (ox.ac.uk)
• Aortic stenosis: a new face for an old disease. (springer.com)
• Percentage of left ventricular stroke work loss: a simple hemodynamic concept for estimation of severity in valvular aortic stenosis. (springer.com)
• Diastolic dysfunction in aortic stenosis. (springer.com)
• Reduced left ventricular myocardial blood flow per unit mass in aortic stenosis. (springer.com)
• A mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. (springer.com)
• Why angina in aortic stenosis with normal coronary arteriograms? (springer.com)
• Physiologic changes with maximal exercise in asymptomatic valvular aortic stenosis assessed by Doppler echocardiography. (springer.com)
• Prediction of the severity of aortic stenosis by Doppler aortic valve area determination: prospective Doppler-catheterization correlation in 100 patients. (springer.com)
• Usefulness of dobutamine echocardiography in distinguishing severe from non severe valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients. (springer.com)
• Takeda S, Rimington H, Chambers J. The relation between transaortic pressure difference and flow during dobutamine stress echocardiography in patients with aortic stenosis. (springer.com)
• Patients with stenosis often have a small aortic annulus and severe post-stenotic aortic dilation. (umin.ac.jp)
• I have a bicuspid valve which since birth had aortic stenosis and I am at this point losing weight by diet and mild execrcise. (medhelp.org)
• Subvalvular aortic stenosis (SAS), the most common congenital heart disease in Golden Retrievers, Newfoundlands and Rottweilers, is a troublesome disease. (grca.org)
• It is divided, on a functional basis, into aortic sclerosis, in which the leaflets do not obstruct left ventricular outflow, and aortic stenosis, in which obstruction to left ventricular outflow is present. (ahajournals.org)
• 2 Aortic stenosis is present in 2% to 5% of very elderly patients, 1,3 is the second most common indication for cardiac surgery, 4 and carries an 80% 5-year risk of progression to heart failure, valve replacement, or death. (ahajournals.org)
• People with aortic stenosis (narrowing of the aortic valve) can have no symptoms for a long period of time. (uclahealth.org)
• While medication and lifestyle choices can help slow the progress of aortic stenosis, valve repair or replacement remains the only definitive treatment. (uclahealth.org)
• Introduction: Aortic stenosis (AS) is the most common hemodynamic significant valvular heart disease and affects about 2% of the population. (dissertations.se)
• Evaluation of AVS can be performed with Doppler echocardiography, and its presence can result in aortic valve stenosis, which is reflected by increased aortic systolic velocities 1 - 4 . (scielo.br)
• In November 2011, the U.S. Food and Drug Administration (FDA) approved a new treatment for heart patients with severe aortic valve stenosis who are not good candidates for open-heart valve replacement surgery. (sharecare.com)
• Aortic stenosis (AS) is the most common valve disease among the adult population, in the majority of the cases it only requires treatment in advanced age. (centerwatch.com)
• Transcatheter aortic valve implantation (TAVI) has become available as an alternative treatment for very high risk or even inoperative patients who are suffering from symptomatic aortic stenosis. (centerwatch.com)
• Aortic stenosis happens when your aortic valve does not open all the way causing pressure to build in the left ventricle. (utah.edu)
• Consuming calcium by drinking calcium-rich drinks or taking calcium supplements does not increase the risk of aortic stenosis. (utah.edu)
• Today rheumatic fever is rare in the United States, but an older adult that had the fever as a child may be at higher risk of developing aortic stenosis. (utah.edu)
• PubMed is a searchable database of medical literature and lists journal articles that discuss Subvalvular aortic stenosis. (nih.gov)
• We summarise the natural history and pathophysiology of aortic stenosis and regurgitation, the indications for surgery, the advantages and disadvantages of tissue, mechanical, homograft and autograft aortic valve replacement, and the prediction of operative mortality for individual patients. (bjcardio.co.uk)
• Hemodynamic measurements are a crucial component of diagnosing patients with aortic stenosis and evaluating their need for valve replacement surgery. (reachmd.com)
• Dr. Rick Stouffer, Professor of Medicine and Cardiology at the University of North Carolina School of Medicine, underscores the value of hemodynamics in managing aortic stenosis, distinguishing critical disease from low-gradient or pseudo-aortic stenosis and cardiac dysfunction. (reachmd.com)
• Valvar aortic stenosis is a spectrum, with significant valve obstruction treated in infancy or childhood. (pted.org)
• The other end of the spectrum is mild stenosis or commonly just a bicuspid aortic valve. (pted.org)
• As aortic stenosis can be progressive, even mild stenosis should be followed regularly until adulthood. (pted.org)
• For infants, the most common treatment of valvar aortic stenosis is a balloon valvuloplasty, in which the narrowed aortic valve is relieved by the inflation of a balloon. (pted.org)
• Moderate aortic insufficiency, especially if some degree of stenosis persists, is poorly tolerated by the left ventricle and will likely result in aortic valve replacement. (pted.org)
• In Discrete Subvalvar Aortic Stenosis (DSVAS), a fibrous ridge obstructs the outflow tract from the left ventricle into the aorta. (pted.org)
• When aortic insufficiency develops most cardiologists recommend surgical removal of the sub-valvular stenosis in order to halt any further progression of the aortic insufficiency. (pted.org)
• In this form of aortic stenosis, an hour glass-like narrowing or, less frequently, a more irregular narrowing, exist in the aorta above the aortic valve. (pted.org)
• We have entered a new era in understanding degenerative aortic stenosis in elderly patients. (jaoa.org)
• With the aging of the US population and the progressive decrease in coronary heart disease prevalence in the past 50 years, aortic stenosis has become a major cardiac concern. (jaoa.org)
• A new classification of aortic stenosis recognizes 4 categories based on flow state (normal or low) and valve gradient (high or low). (jaoa.org)
• Aortic stenosis (AS) is the most common cardiac valve disease in the United States. (jaoa.org)
• The response of the left ventricle is key to understanding the progression to severe, symptomatic aortic stenosis. (jaoa.org)
• Stöbe, S. / "Pure" severe aortic stenosis without concomitant valvular heart diseases : echocardiographic and pathophysiological features . (aau.dk)
• Severe calcific aortic stenosis is relatively common, and unless treated with valve replacement it carries an adverse prognosis. (bmj.com)
• Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, is a new therapeutic modality for treatment of older patients with severe symptomatic aortic stenosis and other comorbidities, who have an inherently high surgical risk. (bmj.com)
• The initial success rates have led to a rapid adoption of this technique in clinical practice in high-risk patients with severe symptomatic aortic stenosis. (bmj.com)
• Over the years, growing evidence has indicated the risk factors for calcific aortic stenosis including lipids, hypertension, male gender, renal failure, and diabetes. (eurekaselect.com)

Descending aorta2

• They can involve the ascending aorta, aortic arch, thoracic descending aorta, and/or abdominal descending aorta. (nature.com)
• A thoracic aortic aneurysm involves the ascending aorta, arch, or descending aorta. (healthline.com)

Diseased aortic valve3

• Also referred to as transcatheter aortic valve implantation (TAVI), is a procedure that replaces your diseased aortic valve with a man-made valve. (einstein.edu)
• Aortic Valve Replacement-The surgeon accesses the diseased aortic valve through an incision in the sternum. (uclahealth.org)
• This new procedure, called transcatheter valve replacement (TAVR), replaces the diseased aortic valve through a tube that is placed in the patient's leg, or through an incision in the chest that is much smaller than traditional surgery. (sharecare.com)

Regurgitation16

• On the other hand, if the valve does not close properly, it may cause aortic regurgitation because some of the blood being pumped out into the aorta regurgitates, or leaks backward, into the left ventricle with each beat. (healthcentral.com)
• Aortic regurgitation is usually asymptomatic until middle age. (healthcentral.com)
• Some causes of aortic regurgitation include congenitally bicuspid (only two cusps instead of three) valves, infective endocarditis, and high blood pressure. (healthcentral.com)
• Aortic insufficiency , or aortic valve regurgitation, in which your aortic valve doesn't close tightly enough. (bidmc.org)
• Aortic valve regurgitation, or aortic insufficiency, occurs when the aortic valve does not close tightly. (medtronic.com)
• Colour Doppler echocardiography showed severe aortic regurgitation, a pressure gradient over the aortic valve (maximum pressure gradient 38 mm Hg, mean gradient 24 mm Hg), and diastolic back flow in the abdominal aorta. (bmj.com)
• People with aortic valve defects can have a variety of symptoms depending on whether blood is leaking into the heart (aortic regurgitation) or blood is restricted from passing into the aorta. (uclahealth.org)
• Long-term experience of surgical treatment for aortic regurgitation attributable to Behçet's disease. (biomedsearch.com)
• In this article, clinical data and surgical outcomes in patients with aortic regurgitation attributable to Behçet's disease were analyzed. (biomedsearch.com)
• METHODS: Nineteen patients with aortic regurgitation attributable to Behçet's disease were surgically treated between March 1986 and June 2008. (biomedsearch.com)
• All deaths occurred after second operations, and the causes of death were low cardiac output (n = 6) and sudden aggravation of aortic regurgitation (n = 3). (biomedsearch.com)
• Naidu Otikunta, A. , Reddy, Y. , Polamuri, P. and Srinivas, R. (2016) Common Complication in an Uncommon Disease: Presence of Aortic Regurgitation in Patient with Quadricuspid Aortic Valve. (scirp.org)
• We present a case of QAV with moderate aortic regurgitation (AR) and left ventricular hypertrophy without ventricular dysfunction, managed conservatively and is followed up since 3 years without any further complications. (scirp.org)
• Figure 2 depicts transthoracic color Doppler echocardiography showing QAV with moderate aortic regurgitation. (scirp.org)
• Even for patients who are treated with the valvotomy only, an aortic valve replacement is ultimately often necessary because of calcification or valve regurgitation. (pted.org)
• Additional monitoring tools, such as molecular imaging, could improve risk stratification, while assessment of severity and prognosis of patients with chronic aortic regurgitation, is desirable. (eurekaselect.com)

Surgical27

• The CVI's Structural Heart Center offers a wide variety of surgical, nonsurgical and hybrid procedures to treat aortic valve disease. (bidmc.org)
• Depending on the severity of disease, your treatment options may include lifestyle changes, medicines and surgical medical procedures. (loyolamedicine.org)
• 1 Although great strides have been achieved during the past years in the management of patients with thoracic aortic aneurysm by new surgical techniques, postoperative mortality and morbidity rates still remain high. (ahajournals.org)
• Patients with bicuspid or unicuspid aortic valves, regardless of surgical status. (clinicaltrials.gov)
• A total of 24 patients with aortic valvular disease associated with congenital bicuspid aortic valve underwent surgical treatment at our institution during the period from January, 1997 to December, 1999. (umin.ac.jp)
• These 24 patients constituted 46.2% (24/52) of all cases of surgical operations for aortic valvular disease. (umin.ac.jp)
• New therapeutic strategies such as endovascular treatment and surgical techniques have appeared to improve conventional surgery in advanced phases of the disease, but until recently, medical treatment has focused on the control of cardiovascular risk factors using beta-blockers to reduce aortic wall stress by reducing blood pressure and heart rate. (springer.com)
• Surgical management of aortic disease. (columbiasurgery.org)
• This study was designed to evaluate the optimal surgical treatment strategy for abdominal aortic aneurysm (AAA) coexisting with coronary artery disease (CAD). (umin.ac.jp)
• 5 Though the disease is associated with substantial clinical consequences, there currently is no effective therapy for the disease other than surgical aortic valve replacement. (ahajournals.org)
• Ten years experience of thoracic and thoracoabdominal aortic aneurysm surgical repair: lessons learn. (biomedsearch.com)
• Thus any preventive or surgical strategy must recognize the aortic disease in its entirety. (worldcat.org)
• She underwent surgical replacement of her aortic valve with a Medtronic Hall prosthetic valve No 21. (bmj.com)
• We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. (uniprot.org)
• Identification of aneurysm-predisposing susceptibility genes may lead to gene-directed surgical therapy of the ascending aorta for patients with bicuspid aortic valves. (uniprot.org)
• The mortality of thoracic aortic diseases (mainly aneurysms and dissections) is high, even with surgical treatment. (dissertations.se)
• This two-and-a-half day live symposium will be the thirteenth in an annual series and will be designed to present and discuss the diagnosis and treatment paradigms for aortic diseases, including medical, endovascular, surgical, and hybrid options. (ctsnet.org)
• We offer both minimally invasive and open surgical procedures for our aortic disease treatments . (henryford.com)
• A great majority of quadricuspid aortic valves do not have a normal function and often necessitate surgical treatment. (scirp.org)
• The surgical procedure entailed complete endoprosthesis removal, closure of the aortic stump below the renal arteries with polypropylene sutures, and omentum coverage. (cdc.gov)
• Surgical aortic valve replacement (SAVR) is very often refused because of advanced age and poor general condition. (centerwatch.com)
• If thoracic aortic disease can be detected early and managed, it gives us the opportunity to select patients for surgical or endovascular repair when the patient is stable," said Loren F. Hiratzka, M.D., who chaired the guidelines writing committee and is the medical director of cardiac surgery for TriHealth, Inc. (Bethesda North and Good Samaritan Hospitals) in Cincinnati, OH. (medicalxpress.com)
• This surgical repair replaces the aortic valve with the patient's own pulmonary valve and then replacing the pulmonary valve with a human donated valve (the Ross repair shown in the animation). (pted.org)
• Surgical treatment was indicated to replace the aortic root using a composite prosthesis and Bentall and De Bono coronary reconstruction. (scielo.org.co)
• Because AS plays such a prominent role in cardiovascular care, there is a renewed interest in several aspects of the disease, including understanding the pathophysiologic processes, predicting adverse cardiac events accurately, diagnosing severe disease, and indicating cardiac surgical procedures. (jaoa.org)
• Surgical treatment involves the tying off and separation of one of the branches of the double aortic arch. (pted.org)
• Traditional surgical valve replacement has been the mainstay in the treatment of severe aortic valvular disease, and in the absence of serious comorbidities it is associated with low operative mortality. (bmj.com)

Aneurysms and dissections6

• This is the first recurrent CNV discovered to be associated with thoracic aortic aneurysms and dissections. (redorbit.com)
• An estimated 8,000 people die annually from thoracic aortic aneurysms and dissections (TAAD). (redorbit.com)
• Researchers found 16p13.1 duplications in eight of 765 patients with non-familial, non-syndrome-related thoracic aortic aneurysms and dissections compared to four patients in 4,569 controls. (redorbit.com)
• Thoracic aortic aneurysms and dissections are familial in up to 20 percent of all cases. (redorbit.com)
• Background: Thoracic aortic aneurysms and dissections (TAAD) have a genetic component with an estimated 20-25% of the patients having a positive family history. (dissertations.se)
• VSMCs of Nos3 −/− mice showed downregulation of 15 genes, of which seven were associated with aortic aneurysms and dissections in the human population. (biologists.org)

Valvular15

• The most common valvular problem in old age is aortic valve disease. (healthcentral.com)
• Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand," International Journal of Cardiology , vol. 169, no. 4, pp. 296-304, 2013. (hindawi.com)
• 2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease. (howstuffworks.com)
• These findings collectively suggest that AS and AR might be partially preventable with potential implications on clinical practice guidelines for prevention of cardiovascular disease in general and valvular heart disease and hypertension in particular," write the authors of the EHJ paper. (eurekalert.org)
• Professor Rahimi said: "The study shows that serious valvular heart diseases that are common at old age are not simply due to aging. (eurekalert.org)
• Guidelines on the management of valvular heart disease. (springer.com)
• An increase of aortic valvular disease associated with congenital bicuspid aortic valve is observed due to the relative decrease of rheumatic valvular diseases. (umin.ac.jp)
• Preoperative and intraoperative evaluation is important in cases of aortic valvular disease associated with congenital bicuspid aortic valve. (umin.ac.jp)
• Valvular disease is rare in patients with JIA 2 and consists of valvulitis with a substrate with non-specific changes of fibrosis and necrosis. (bmj.com)
• Valvular involvement has been described in patients with all types of JIA, 3 the aortic valve being most commonly affected. (bmj.com)
• 4- 9 Valvular disease is associated with severe destructive articular disease. (bmj.com)
• The inclusion criteria for the selection of the sample were all patients undergoing transthoracic Doppler echocardiography during the period mentioned above when the aortic valvular system was evaluated. (scielo.br)
• Here, we developed a 3D in vitro heart valve model that resembles the morphology of the valvular extracellular matrix and mimics the mechanical and physiological behavior of the aortic valve fibrosa and spongiosa. (ssrn.com)
• The assessment of myocardial function in the context of valvular heart disease remains highly challenging. (onlinejacc.org)
• This review gathers and summarizes current evidence regarding the use of these techniques to assess myocardial deformation in patients with valvular heart disease. (onlinejacc.org)

Layers of the aortic wall5

• Aortic dissection occurs when the wall of the aorta bulges so much that the layers of the aortic wall tear. (einstein.edu)
• A break in all three layers of the aortic wall is termed a rupture. (harvard.edu)
• A tearing of the inner lining of the aortic wall, allowing blood to enter and split the layers of the aortic wall. (torrancememorial.org)
• In aortic rupture, all three layers of the aortic wall burst, resulting in massive bleeding inside the body. (medicalxpress.com)
• Play media Aortic dissection (AD) occurs when an injury to the innermost layer of the aorta allows blood to flow between the layers of the aortic wall, forcing the layers apart. (wikipedia.org)

Dissections15

• Yasbeck said medical professionals misdiagnosed her husband's condition as a heart attack, a common occurrence with aortic dissections. (healthline.com)
• Patients with thoracic aortic aneurysms that lead to acute aortic dissections are 12 times more likely to have duplications in the DNA in a region of chromosome 16 (16p13.1) than those without the disease, according to a study led by genetic researchers at The University of Texas Health Science Center at Houston (UTHealth). (redorbit.com)
• Usually described as a sudden, sharp, tearing pain in the chest and back, aortic dissections are often mistaken for a heart attack. (einstein.edu)
• A multi-institutional team led by Dianna Milewicz, M.D., Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) has found a recurrent genetic mutation that has been linked to deadly thoracic aortic dissections in family members as young as 17 years of age. (redorbit.com)
• The majority of the affected family members suffered acute aortic dissections at young ages (17 to 51 years). (redorbit.com)
• Using this management protocol, acute aortic dissections and the associated premature deaths can be prevented. (redorbit.com)
• He was also found to have aortic root dilation and because of his family history of early thoracic aortic dissections at diameters smaller than 5 centimeters, he elected to have surgery. (redorbit.com)
• and nephew, 23, all died from thoracic aortic dissections. (redorbit.com)
• BAV patients are also at high risk to develop aneurysms of the ascending aorta, which may lead to aortic dissections. (clinicaltrials.gov)
• Patients will also be followed up by telephone or email about once a year to determine if they experience any medical complications related to Bicuspid Aortic Valve (BAV), such as aortic aneurysms, aortic dissections or valve disease. (clinicaltrials.gov)
• These are known as thoracic aortic aneurysm (TAA), aortic dissections and aortic ulcerations. (barnesjewish.org)
• Acute aortic dissections are associated with high mortality and morbidity, even when operated on. (dissertations.se)
• A combination of histological examination and in vivo ultrasound imaging was used to investigate aortic dilation and dissections in Nos3 −/− mice. (biologists.org)
• Spontaneous aortic dissections were found in ascending aortas located at the sinotubular junction in ∼13% of Nos3 −/− mice. (biologists.org)
• Anterior chest pain is associated with dissections involving the ascending aorta, while interscapular back pain is associated with descending aortic dissections. (wikipedia.org)

Bicuspid aortic valves8

• However, roughly 80% of people with bicuspid aortic valves will require valve repair or replacement later in life, often in the late 40s or early 50s (this was the case with Arnold Schwartzenegger). (medhelp.org)
• Thoracic aortic aneurysms may be related to hypertension, bicuspid aortic valves, inflammatory conditions, trauma or an underlying genetic disorder, such as Marfan syndrome , Loeys-Dietz aneurysm syndrome , Turner syndrome, familial thoracic aortic aneurysm and dissection syndrome , and vascular Ehlers-Danlos syndromes. (barnesjewish.org)
• We hypothesize that genotypic variations in patients with bicuspid aortic valves contribute to this observed variability in aortic phenotype. (uniprot.org)
• Results were compared with control subjects with trileaflet aortic valves (n = 94), bicuspid aortic valves, and normal aortas (n = 22) and in subjects with tricuspid aortic valves and thoracic aortic aneurysms (n = 28). (uniprot.org)
• RESULTS: Four unique, nonsynonymous (3 novel) variants were identified in 5 (10.4%) of 48 patients with concomitant bicuspid aortic valves and thoracic aortic aneurysms compared with only 3 (2.1%) of 144 control subjects (P = .02). (uniprot.org)
• Of these, 2 novel missense mutations, A1343V and P1390T, were observed only in patients with bicuspid aortic valves and tricuspid aortic aneurysms. (uniprot.org)
• CONCLUSIONS: This targeted analysis involving NOTCH1 exons previously implicated in familial and sporadic bicuspid aortic valve demonstrates overrepresentation of NOTCH1 missense variants among patients with bicuspid aortic valves and thoracic aortic aneurysms. (uniprot.org)
• The study compared the outcomes of 13,205 patients-2,079 with bicuspid aortic valves and 73 with Marfan syndrome-who had AVR replacement between 1995 and 2010. (acc.org)

Diagnosis18

• Loyola's cardiology and heart surgery program is nationally recognized for our diagnosis and treatment of aortic conditions. (loyolamedicine.org)
• Aortic disorders often require a team approach to diagnosis. (loyolamedicine.org)
• A diagnosis of aortic valve disease means your aortic valve doesn't work properly. (medtronic.com)
• Diseases of the thoracic aorta represent often life-threatening conditions, and despite growing consciousness among the physicians about the role of early diagnosis in determining the appropriate treatment, they are still far from holding precise guidelines in management of acute and chronic aortic syndromes. (ahajournals.org)
• From March 1999 to October 2003, 132 consecutive patients (113 male and 19 female) were admitted with clinical and instrumental diagnosis of either acute (44) or chronic (88) aortic disease. (ahajournals.org)
• Others have normal valves at birth but develop valve disease due to rheumatic fever - an inadequately treated strep infection that affects the heart, which, fortunately, is much less common today because of advances in the diagnosis and treatment of strep throat (and why it's important when treating strep to take the full course of the prescribed antibiotic even if symptoms have abated). (everydayhealth.com)
• This book is driven by the considerable progress made by novel imaging techniques in understanding the pathophysiology and evolution of aortic disease and its diagnosis. (springer.com)
• The diagnosis aortic valve insufficiency and secondary angina pectoris was made. (bmj.com)
• Doctors can often diagnosis aortic valve disease during a physical examination. (uclahealth.org)
• Learn more about aortic disease diagnosis and aortic disease treatments available at Henry Ford. (henryford.com)
• Two-dimensional (2D) echocardiography showed enlarged left ventricle and established the diagnosis of quadricuspid aortic valve. (scirp.org)
• Aortic diseases need excellent radiological and interventional facilities for early diagnosis and further treatment planning. (amrita.edu)
• The Amrita Centre for Aortic Diseases has the latest 256 slice high-definition CT scanners and 3T MRI machines for aortic imaging, diagnosis and planning of complex aortic interventions. (amrita.edu)
• Now, new clinical guidelines spearheaded by the American College of Cardiology (ACC) and the American Heart Association (AHA) not only offer new recommendations for the diagnosis and management of thoracic aortic disease (TAD), they deliver a powerful message to physicians and patients: Early diagnosis and treatment can save lives. (medicalxpress.com)
• Recent scientific and clinical advances drove the development of guidelines to aid physicians in the diagnosis and management of aortic dissection, aortic aneurysm and other forms of TAD, said Kim A. Eagle, M.D., director of the University of Michigan Cardiovascular Center in Ann Arbor and co-author of the guidelines. (medicalxpress.com)
• Therefore, cells mechanical properties can be used as a marker for the early diagnosis of pathologies as cancer or cardiovascular diseases. (videolectures.net)
• Women with symptoms of aortic aneurysm will need an imaging test to confirm the diagnosis and determine the best treatment. (hearthealthywomen.org)
• Complementary studies (chest x-ray, electrocardiogram, angiography, tomography, and echocardiogram) were performed, obtaining a diagnosis of Stanford type A ascending aortic dissection. (scielo.org.co)

Mitral6

• You may remember from school that the heart has four valves, two of which rarely cause trouble (the pulmonary and the tricuspid), and two of which are more frequently in need of replacement (the mitral and the aortic). (everydayhealth.com)
• We performed aortic valve replacement in 22 patients, aortic root replacement in 1 patient and aortic root remodeling in 1 patient in combination with mitral valve plasty in 3 patients, coronary artery bypass grafting in 3 patients and closure of the atrial septal defect (ASD) in 1 patient. (umin.ac.jp)
• The specimen is a heart, the left ventricle being laid open to display the cavity and mitral and aortic valves. (monash.edu)
• The following report presents the case of a 26-year-old man with a history of Marfan syndrome, retrosternal lancinating pain, nausea, vomiting, and medium effort dyspnea that evolved to orthopnea, perioral cyanosis, murmur of aortic insufficiency and mitral systolic murmur. (scielo.org.co)
• In patients with aortic and/or mitral valve disease the presence of pulmonary hypertension (PH) indicates a decompensated state of the disease with left ventricular and left atrial dysfunction and exhausted compensatory mechanism, i.e., a state of heart failure. (uzh.ch)
• In the present review we discuss the pathophysiology and clinical impact of PH in patients with aortic and mitral valve disease, the comprehensive non-invasive and invasive diagnostic approach required to define treatment of PH, and recent insights from mechanistic studies, registries and randomized studies, and we provide an outlook regarding gaps in evidence, future clinical challenges, and research opportunities in this setting. (uzh.ch)

Rupture16

• Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to increased GSK-3b-mediated activation of ROCK and induction of a hypercontractile phenotype. (nature.com)
• An aortic rupture happens when the aortic wall tears open completely. (healthline.com)
• If you have an at-risk section of your aortic arch, such as due to an aneurysm (ballooning and weakening of the aortic wall) or dissection (split within the muscle of the aortic wall, placing it at risk of rupture), it may be necessary to reinforce or repair segments of your aorta. (einstein.edu)
• When the aorta enlarges to a certain size, elective surgery can be performed in order to avoid emergency repair to attempt to repair a catastrophic aortic dissection or rupture. (redorbit.com)
• No stent graft-related complications were detected, although only in 1 case, an asymptomatic rupture of the Excluder connecting bar was found with a perforation of the fabric and an intra-aortic exposition of the bar itself. (ahajournals.org)
• Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair. (greenmedinfo.com)
• Thoracic aortic disease is serious because weak, fragile aortic tissue under high pressure may tear or rupture, causing life-threatening bleeding. (torrancememorial.org)
• When the risk of aortic dissection or rupture is greater than that associated with surgery, elective surgery is offered to replace the diseased section of the aorta with a Dacron graft. (torrancememorial.org)
• Aortic dissection and aortic rupture may be fatal and require emergency care at a center with expertise in the care of patients with these conditions. (barnesjewish.org)
• Using cocaine, even once, creates the risk of life-threatening aortic dissection or rupture, and can make systolic blood pressure soar. (vcuhealth.org)
• Abdominal aortic aneurysm (AAA) is a common disease that is life threatening when rupture occurs. (dissertations.se)
• The risk of rupture from aortic dissection is more substantial than from aortic aneurysm. (imaginis.com)
• The results of treatment for stable disease are far better than for acute-and often catastrophic-aortic rupture or dissection. (medicalxpress.com)
• Patients should tell their physicians not only about close relatives with aortic aneurysm, dissection, or rupture, but also about any family history of unexplained sudden death. (medicalxpress.com)
• Aortic dissection can quickly lead to death from insufficient blood flow to the heart or complete rupture of the aorta. (wikipedia.org)
• It is usually associated with pericardial tamponade, severe aortic insufficiency, or rupture of the aorta. (wikipedia.org)

Valve implantation4

• Optimal pain management after aortic valve implantation: an opportunity to improve outcomes after transapical access in the future? (bmj.com)
• Transcatheter aortic valve implantation (TAVI) -The surgeon threads a catheter - a long, flexible tube - through an artery, usually in the groin or pelvis. (uclahealth.org)
• Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, was first implanted by Andersen in 1993 in a closed chest experimental pig model. (bmj.com)
• Objectives This study sought to determine the effects of chronic obstructive pulmonary disease (COPD) on clinical outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) and to determine the factors associated with worse outcomes in COPD patients. (onlinejacc.org)

Symptoms27

• An aortic valve disorder usually does not cause any symptoms in its early stages. (healthcentral.com)
• Actress Amy Yasbeck wants families to know the symptoms of thoracic aortic disease, which kills an estimated 15,000 to 20,000 people in the United States every year. (healthline.com)
• Symptoms may vary depending on the type of aortic valve disease you have, and some patients do not have any symptoms. (bidmc.org)
• Symptoms of aortic valve endocarditis may also include flu-like symptoms and blood in the urine. (bidmc.org)
• If you don't have any symptoms of aortic valve disease, or if your symptoms are mild, your doctor may simply monitor your condition on a regular basis, including having you undergo periodic echocardiograms. (bidmc.org)
• Stephen Harris' brother was the first to have symptoms of an aortic dissection when he was 51 years old and was found to have a descending thoracic aortic dissection. (redorbit.com)
• Your medical history, health evaluation, and symptoms could indicate the presence of an aortic disorder. (loyolamedicine.org)
• While these symptoms can be indicative of an aortic disorder, additional tests will be needed definitively diagnose your specific condition. (loyolamedicine.org)
• Without serious symptoms, aortic valve disease may simply require an easygoing lifestyle -- due to the heart's limited ability to deliver oxygenated blood -- and regular cardiology exams. (howstuffworks.com)
• The disease is characterised by restricted blood flow through the valve, with affected individuals commonly experiencing symptoms such as chest pain, shortness of breath, heart palpitations and, in more severe cases, collapse and loss of consciousness. (ox.ac.uk)
• For additional information on risks, signs and symptoms, feel free to visit community resource The John Ritter Foundation for Aortic Health . (hoag.org)
• Aortic diseases often go unnoticed because patients rarely feel any symptoms. (torrancememorial.org)
• Despite the lack of symptoms in stable conditions, most aortic diseases have a high morbidity and mortality. (springer.com)
• Most thoracic aortic aneurysms do not cause symptoms and are not detectable on a routine physical examination. (barnesjewish.org)
• Success means that the patient resumes a completely independent life without symptoms of disease or consequence of surgery. (columbiasurgery.org)
• It's important to understand and recognize the causes, symptoms, and treatments for these two types of aortic valve disease. (utah.edu)
• Since the aortic valve regulates the blood flow between the aorta and the left ventricle, this restricted blood flow causes symptoms like shortness of breath, fatigue, and passing out. (utah.edu)
• In some patients the aortic valve may narrow slightly but they will never have any noticeable symptoms. (utah.edu)
• Although the wall of the aorta can become dangerously thin, patients with an aortic aneurysm often have no symptoms unless the aneurysm ruptures. (medicalxpress.com)
• Monarch's tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. (nih.gov)
• Women with large aortic aneurysms that are causing symptoms need immediate treatment to prevent if from bursting. (hearthealthywomen.org)
• You should learn to recognize the symptoms of aortic disease and talk to your doctor if you experience them. (hearthealthywomen.org)
• Even if you do not have any symptoms, certain women at high risk for an aortic aneurysm should have a screening test so that it can be diagnosed and treated early. (hearthealthywomen.org)
• A medical history and physical examination are the first steps in evaluating women with signs or symptoms of aortic disease. (hearthealthywomen.org)
• Women with the classic symptoms of an aortic aneurysm that has ruptured-constant, severe abdominal and/or back pain (sometimes radiating to the groin, buttock, or legs), a pulsing mass in the abdomen, and low blood pressure-should undergo immediate surgery to diagnose and repair the aneurysm. (hearthealthywomen.org)
• Although the physical exam can detect signs of a large aneurysm, most aortic aneurysms do not cause any symptoms. (hearthealthywomen.org)
• Women being evaluated for aortic disease may also have additional imaging tests (such as a chest X-ray or echocardiogram ) to rule out heart and lung problems that could be causing their symptoms. (hearthealthywomen.org)

Calcific aortic valve14

• Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. (hindawi.com)
• These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease. (ahajournals.org)
• Calcific aortic valve disease is identified by thickening and calcification of the aortic valve leaflets in the absence of rheumatic heart disease. (ahajournals.org)
• The lack of medical therapies for calcific aortic valve disease can be traced to at least two important issues, one intellectual, the other practical. (ahajournals.org)
• The first was the long-held notion that calcific aortic valve disease was a "degenerative," and therefore unmodifiable, condition. (ahajournals.org)
• 6 However, more recent studies have demonstrated convincingly that calcific aortic valve lesions have many features characteristic of an active pathobiological process, including chronic inflammation, 7-9 lipoprotein deposition, 10-12 active calcification, 13-18 and renin-angiotensin system activation. (ahajournals.org)
• Only very recently has a purported mouse model of calcific aortic valve disease been described. (ahajournals.org)
• Nonetheless, through a combination of epidemiological studies, histopathologic evaluation of human lesions, and genetic epidemiology, the past several years have seen rapid advances in our understanding of calcific aortic valve disease pathogenesis. (ahajournals.org)
• 37 This review will summarize our current understanding of the pathogenesis of calcific aortic valve disease, attempt to place what currently is known in the context of on-going or recently-completed clinical trials, and identify some areas for future investigation. (ahajournals.org)
• Over the past several years, a number of risk factors for calcific aortic valve disease have been identified. (ahajournals.org)
• In this talk, we will analyze the mechanical properties of aortic valve interstitial cells (VICs), the predominant constituent of aortic valves, governing ECM structure and composition, in the onset of calcific aortic valve disease (CAVD). (videolectures.net)
• Calcific aortic valve disease is relatively common in the high-income countries, affecting between 4% and 5% of adults above the age of 75 years, and unless corrected, it carries significant morbidity and mortality. (bmj.com)
• Calcific aortic valve disease is a common disease in the elderly associated with significant morbidity and mortality. (eurekaselect.com)
• Also, several studies have investigated the role of biomarkers regarding their utility in the screening of calcific aortic valve disease and their putative clinical value, though their role still remains undetermined. (eurekaselect.com)

Abdominal aortic aneurysms2

• Approximately 20% of thoracic aortic aneurysms are associated with an autosomal pattern of inheritance from a mutation in a single gene, whereas abdominal aortic aneurysms (AAAs) do not typically demonstrate such inheritance but rather seem to present as a polygenic disorder involving variants of weaker effect. (ctsnet.org)
• This study aimed to investigate the clinical course of BD patients with abdominal aortic aneurysms (AAA). (springer.com)

Insufficiency3

• To our knowledge, this case is the first illustrated report of typical rheumatoid nodules found in an aortic valve removed owing to aortic valve insufficiency in a patient with polyarticular JIA. (bmj.com)
• Furthermore, our case report confirms the possibility of successful mechanical aortic valve replacement in a case of severe progressive aortic valve insufficiency and secondary angina pectoris in a patient with polyarticular JIA. (bmj.com)
• However, because of its proximity to the aortic valve, it can often result in the development of aortic insufficiency. (pted.org)

Dilation3

• In 50% of bicuspid can develop aortic dilation. (amrita.edu)
• Some patients with a bicuspid aortic valve may also develop dilation (enlargement) of the aorta. (pted.org)
• This study demonstrates that, in addition to congenital BAV formation, disrupted endothelial-mediated nitric oxide (NO) signalling in Nos3 −/− mice also causes aortic dilation and dissection, as a consequence of inhibited elastic fibre formation in VSMCs within the ascending aorta. (biologists.org)

Severe7

• In 1990, a third leading cause of embolic stroke was identified on transesophageal echocardiography (TEE), namely severe atherosclerotic plaques in the aortic arch. (ahajournals.org)
• All 3 had severe plaque in the aortic arch on TEE. (ahajournals.org)
• TEE showing aortic arch with very severe atherosclerotic plaque. (ahajournals.org)
• If damage to your aortic valve is severe, surgery may be necessary to repair or replace the valve. (bidmc.org)
• Cheryl Harris, Stephen's wife, said their daughter Jenny was eight months pregnant in 2006 when she began to have severe pain in her back just like her uncle but since aortic disease mostly affects older men, they didn't connect it to her. (redorbit.com)
• EH: The normal treatment for severe aortic valve disease is surgery - we take out the old aortic valve and sew in a new one. (thestar.com)
• BACKGROUND: Cardiac involvement in Behçet's disease is a rare but severe complication and presents challenges to cardiac surgeons as a result of late valve detachment or pseudoaneurysms of the aortic root after valve surgery. (biomedsearch.com)

Acute6

• The gene known as PRKG1 makes a protein called cGMP-dependent kinase, type I. The PRKG1 mutation alters the function of the protein and causes the muscle cells in the wall of the aorta to respond incorrectly to pulsatile blood flow from the heart, and the change in this one protein ultimately causes thoracic aortic aneurysm and acute aortic dissection. (redorbit.com)
• Conclusions- Endovascular treatment of thoracic aortic diseases, even in the acute phase, may represent a valid option with a low mortality rate. (ahajournals.org)
• Moreover, we try to search for the real behavior of native aortic wall in response of modifications in the acute and chronic phase induced by aortic disease as well as by introducing a noncompliant system in a semi-compliant structure such as aorta. (ahajournals.org)
• Our center also participates in the International Registry of Acute Aortic Dissection and the Valve-Sparing Aortic Root Replacement Registry in Marfan Syndrome. (barnesjewish.org)
• OBJECTIVES: Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection. (uniprot.org)
• Acute thoracic aortic dissection is caused by a tear in the intimai lining of the aorta, and is a symptom of acute aortic syndrome. (scielo.org.co)

Heart Disease9

• Aortic valve disease can be congenital, result from infection, occur as a result of rheumatic heart disease, result from the processes of aging, or be of unknown origin. (healthcentral.com)
• Heart Disease and Saturated Fat: Do the Dietary Guidelines Have It All Wrong? (medhelp.org)
• When aortic dissection is confused with heart disease, it's fatal," Yasbeck told Healthline. (healthline.com)
• We asked Eric Horlick, a cardiologist and director of structural heart disease intervention at the Peter Munk Cardiac Centre about a new program that ensures patients get prompt, life-saving care. (thestar.com)
• Laing SP, Swerdlow AJ, Slater SD et al (2003) Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes. (springer.com)
• Treatment options for heart disease depend on the type of disease you have. (sharecare.com)
• The incidence of rheumatic heart disease has dropped so much in North America that, in my experience, rheumatic AS is rarely seen. (jaoa.org)
• With a nod to tradition, it should be noted that there are 3 forms of AS from the perspective of congenital heart disease. (jaoa.org)
• Anyone with congenital heart disease, repaired or non-repaired, should consult with their cardiologist about physical activity to review the risks. (pted.org)

Form of aortic1

• Abdominal aneurysms are most common form of aortic aneurysm, comprising 75% of cases. (imaginis.com)

Types of aortic2

• There are three types of aortic aneurysms. (healthline.com)
• Using a team approach to care, Henry Ford's Multidisciplinary Aorta Program provides advanced care and lifelong management for all types of aortic disorders. (henryford.com)

Atherosclerotic8

• Aortic atherosclerotic lesions have been referred to in several different ways in the medical literature. (ahajournals.org)
• The degradative SMC phenotype also worsens atherosclerotic disease and could thus be considered as a therapeutic target for diverse aortic diseases. (jci.org)
• Light to moderate alcohol consumption is associated with a lower atherosclerotic burden of aortic plaque. (greenmedinfo.com)
• Blood pressure should be considered as a major risk factor for aortic valve disease, much in the same way as we think of elevated blood pressure as a risk factor for atherosclerotic disease. (eurekalert.org)
• We have investigated the presence of the connective-tissue-degrading metalloproteinases in homogenates prepared from atherosclerotic, aneurysmal and control aortic media. (portlandpress.com)
• Ulceration of atherosclerotic plaque penetrates into the aortic wall. (torrancememorial.org)
• The obligate intracellular bacterium Chlamydia pneumoniae (Cp), a common human pathogen, has been associated with atherosclerotic cardiovascular disease. (dissertations.se)
• Diabetes is a risk factor for atherosclerotic disease but negatively associated with the development and progression of abdominal aortic aneurysm (AAA). (ovid.com)

Complications6

• This book follows the concept of perceiving the entire aorta as one functional organ assuming that all individual pathologies and local interventional procedures affect the up- and downstream segments with consequences for complications and disease progression. (worldcat.org)
• Our expert team manages the complications of aortic valve disease using the latest advancements in medicine and repairs the valve using both traditional and minimally invasive techniques. (uclahealth.org)
• Our Multidisciplinary Aorta Program offers care for a range of aortic disorders helping you avoid life-threatening complications. (henryford.com)
• Aim: To report a case with quadricuspid aortic valve accompanied with complications. (scirp.org)
• Patients with Marfan syndrome displayed higher rates of aortic complications in long-term follow-up after aortic valve replacement (AVR) than patients with bicuspid aortic valve disease, according to results of a study published June 1 in the Journal of the American College of Cardiology . (acc.org)
• Neurological complications of aortic dissection, such as stroke and paralysis, are due to the involvement of one or more arteries supplying portions of the central nervous system. (wikipedia.org)

Transcatheter Aortic Valve Repla1

• Surgeons at UCLA have helped pioneer Transcatheter Aortic Valve Replacement to provide high-risk patients with an option for permanent repair. (uclahealth.org)

TAVI3

• For them, we turn to minimally invasive procedures, including the transcatheter aortic valve implant (TAVI). (thestar.com)
• 9 It was a true 'resurrection' for Cribier and his whole team performing the first TAVI in an inoperable patient in 2002 10 , 11 using a transeptal antegrade approach and balloon-expandable aortic calve prosthesis, while at the same time in the USA, animal studies were being carried out to develop a transapical method of implantation. (bmj.com)
• Since 2012, TAVI has been performed in more than 50 000 patients worldwide and a number of different aortic prostheses have since been developed. (bmj.com)

Cardiovascular disease6

• E. E. Creemers, A. J. Tijsen, and Y. M. Pinto, "Circulating MicroRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? (hindawi.com)
• Gamma-oryzanol has benefits in the treatment of cardiovascular disease. (greenmedinfo.com)
• Prolonged flaxseed flour intake decreased the thickness of the aorta and modulates some modifiable risk factors related to cardiovascular disease in rats. (greenmedinfo.com)
• Rawshani A, Rawshani A, Franzén S et al (2017) Mortality and cardiovascular disease in type 1 and type 2 diabetes. (springer.com)
• Prince CT, Secrest AM, Mackey RH, Arena VC, Kingsley LA, Orchard TJ (2010) Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes. (springer.com)
• Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease. (thefreelibrary.com)

Affecting the aortic valve1

• Bicuspid aortic valve disease , a congenital defect affecting the aortic valve. (bidmc.org)

Degenerative3

• Traditionally, thoracic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in extracellular matrix and loss of smooth muscle cells (SMCs) in the medial layer of the aortic wall. (jci.org)
• Curcumin may have a beneficial effect in degenerative aortic aneurysms. (greenmedinfo.com)
• With the bicuspid aortic valve, the eccentric leaflet configuration leads to increased mechanical stress and clinical presentation occurs 2 decades earlier than that of degenerative trileaflet AS. (jaoa.org)

Valves6

• Aortic Valve Disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. (healthcentral.com)
• The aortic valve is one of four valves that control the flow of blood into and out of the heart. (healthcentral.com)
• One of these valves, the aortic valve , guards the passageway between the left ventricle and the aorta , your primary supply artery for oxygen-rich blood. (howstuffworks.com)
• One of the reasons the right side valves are less often involved in disease is because the blood pressure on the right side of the heart is dramatically lower than that on the left. (everydayhealth.com)
• The relationship between these two pathologies is explained by a progressive release in AVS of oxidized low-density lipoprotein that accumulates in the valves and extend through the coronary ostia towards the arteries where they are deposited, leading to coronary disease. (scielo.br)
• Here we found that the number of myofibroblasts (correlated to disease-associated phenotype) was similar to the case of healthy valves, and that fibroblasts on CNT matrix resulted in higher stiffness and higher number of focal adhesions, with respect to reference glass. (videolectures.net)

Leaflets8

• 1. In a healthy aortic valve , three thin leaflets open and close properly. (medtronic.com)
• Your aortic valve normally has three snugly fitting, triangular leaflets (sometimes called cusps or flaps) attached to a ring of tissue called the annulus . (howstuffworks.com)
• In the case of Mr. Williams it is possible that he was born with an aortic valve that has two leaflets instead of the normal three, predisposing him to calcification at an earlier age (this is speculation on my part since the details of his case haven't been revealed). (everydayhealth.com)
• Sometimes, doctors can open a stenotic valve by inserting a catheter with a tiny balloon into the body, pushing it through a vein to the aortic valve and then expanding the balloon, knocking the leaflets fully apart. (howstuffworks.com)
• Aortic valve sclerosis (AVS) is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. (scielo.br)
• In addition, people whose aortic valve has only two leaflets (bicuspid valve) instead of the normal three leaflets may be at increased risk for an aortic aneurysm. (medicalxpress.com)
• Also, the valvuloplasty technique is not very effective in adults whose aortic valve leaflets have become calcified. (pted.org)
• Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. (biologists.org)

Marfan Syndrome9

• As the largest artery in your body, the aorta is a critical part of your circulatory system and can cause serious heart problems when weakened or torn as a result of high blood pressure, smoking, injuries, connective tissue disorders, congenital conditions like Marfan syndrome, atherosclerosis (the hardening of the arteries due to buildup of fat and cholesterol), and other conditions and diseases. (einstein.edu)
• Certain genetic syndromes that affect connective tissue, including Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome vascular type and Turner syndrome, can greatly increase the risk of developing an aortic aneurysm. (hoag.org)
• All first-degree relatives (i.e., parents, siblings and children) of those with bicuspid aortic disease, Ehlers-Danlos syndrome, Marfan syndrome and other connective tissue disorders should have a complete aortic checkup. (vcuhealth.org)
• Other causes include hypertension (high blood pressure), Marfan syndrome (genetic connective tissue disease), infectious diseases such as syphilis or tuberculosis, or possibly a genetic predisposition in the case of abdominal aortic aneurysm. (imaginis.com)
• Risk factors for TAD include poorly controlled high blood pressure, advancing age, male gender, atherosclerosis, inflammatory diseases that damage the blood vessels, and certain genetic conditions that weaken connective tissue, such as Marfan syndrome. (medicalxpress.com)
• assessed the long-term follow-up of thoracic aortopathy after AVR in patients with bicuspid aortic valve disease and those with Marfan syndrome. (acc.org)
• The results of the study showed that patients with Marfan syndrome were 14 times more likely to present with aortic dissection during long-term follow-up and five times more likely to undergo thoracic aortic surgery. (acc.org)
• The authors of the study note that these results "provide additional support for the discrete treatment algorithms for patients with bicuspid valve disease," as the operative management of these patients has previously been extrapolated based on Marfan syndrome patients. (acc.org)
• AD is more common in those with a history of high blood pressure, a number of connective tissue diseases that affect blood vessel wall strength including Marfan syndrome and Ehlers Danlos syndrome, a bicuspid aortic valve, and previous heart surgery. (wikipedia.org)

Surgery16

• Can aortic valve disease be detected early enough to eliminate the need for surgery? (healthcentral.com)
• Hybrid aortic surgery combines traditional open-heart surgery and endovascular stent graft procedures. (einstein.edu)
• In October 2012, Anthony Estrera, M.D., associate professor of cardiovascular surgery at the UTHealth Medical School and the Memorial Hermann Heart and Vascular Institute, performed the graft replacement of his aortic root. (redorbit.com)
• I do not have the same problem as you, but have had open heart surgery, aortic valve replacement and took care of my father after his CABG x 5. (healingwell.com)
• Now with news that former First Lady Barbara Bush has undergone open heart surgery to replace her defective valve and that comedian Robin Williams will soon have the same procedure, suddenly the aortic valve is front and center and on everyone's minds. (everydayhealth.com)
• Aorta and Aortic Valve Surgery - Keyhole Approaches. (howstuffworks.com)
• Despite the extent of aneurysmal lesions and high frequency of association with visceral and supraaortic vessel lesions, the outcome of surgery in patients presenting with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease was satisfactory. (biomedsearch.com)
• In our center, a multidisciplinary approach to the evaluation and management of thoracic aortic disease is offered, involving specialists from cardiac and vascular surgery, cardiology, medical genetics and radiology. (barnesjewish.org)
• When surgery is necessary, the most recent advances in thoracic aortic surgery are available. (vcuhealth.org)
• We perform more than 200 major aortic procedures each year at NYP/Columbia's Aortic Surgery Program. (columbiasurgery.org)
• He frequently performs coronary artery bypass surgery, aortic valve and aortic root replacement surgery, surgery to correct thoracic aneurysms, heart valve surgery, aortic surgery and heart transplant surgery. (jspubs.com)
• Patients with a history of an aortic aneurysm, aortic surgery or aortic dissection and their family are welcome to attend. (ottawaheart.ca)
• Such patients need to be shifted immediately to centers with expertise in aortic dissection surgery. (amrita.edu)
• Dr. Hans Joachim Schafers, Director, Department of Thoracic & Cardiovascular Surgery, Saarland, University Medical Center, Germany, said that bicuspid aortic valve disease roughly affects 1 to 2% of population. (amrita.edu)
• What Types of Heart Diseases are Treated with Surgery? (sharecare.com)
• Therefore, balloon valvuloplasty remains an emergency option as a bridge to aortic valve surgery. (bmj.com)

Atherosclerosis4

• Although most investigators feel that aortic atherosclerosis is a leading cause of embolic disease, doubts have been raised. (ahajournals.org)
• 1 Correlations also were found between elevated levels of lipoprotein(a) [Lp(a)] and low-density lipoprotein cholesterol (LDL) and increased risk of aortic sclerosis, 1 though the relative risks appeared to be lower than those typically reported for atherosclerosis. (ahajournals.org)
• Ohyama Y, Ambale-Venkatesh B, Noda C et al (2017) Aortic arch pulse wave velocity assessed by magnetic resonance imaging as a predictor of incident cardiovascular events: the MESA (multi-ethnic study of atherosclerosis). (springer.com)
• Aortic aneurysms are believed to be caused by the gradual weakening of the artery due to atherosclerosis, arterial narrowing and hardening from cholesterol plaque build-up. (imaginis.com)

Aneurysm repair2

• Associated supraaortic trunks lesions were present in 15 patients (45%) and were treated in 12 patients, including 8 in first-stage procedures prior to thoracoabdominal aortic aneurysm repair. (biomedsearch.com)
• Direct spinal cord perfusion pressure monitoring in extensive distal aortic aneurysm repair. (biomedsearch.com)

Cardiac1

• Would you,please explain (be specific) what does it mean when on average middle age male patient cardiac mri report is written the following 'There is mild prominence of aortic root which measures 3.9 cm at sinuses of Valsalva.The sinotobular junction is maintained.More distally,the thoracic aorta is normal in size.There is no evidence of dissection. (medhelp.org)

Clinical12

• This Review discusses the latest findings and current theories on the pathogenesis of abdominal aortic aneurysm (AAA) and highlights potential medical therapies for AAA, summarizing previous, ongoing, and potential clinical trials of medical interventions for small AAAs. (nature.com)
• The results of this study could affect clinical care because it appears patients with 16p13.1 duplications have an aggressive form of the thoracic aortic disease that causes aneurysms to dissect at smaller diameters," Milewicz said. (redorbit.com)
• 8-10 More recently, the ability to image aortic plaque and its contents has improved significantly through the use of different imaging modalities, and our understanding of the associated clinical syndromes has increased. (ahajournals.org)
• Steve Harris traveled to Houston to consult with Milewicz and the clinical team at the Multidisciplinary Aortic and Vascular Disease Clinic. (redorbit.com)
• To be included in the study, patients must have a bicuspid or unicuspid aortic valve, documented by clinical history or imaging studies. (clinicaltrials.gov)
• Clinical research in the Aortic Disease Program at the Massachusetts General Hospital Fireman Vascular Center combines leading research with patient care to develop innovative options to treat and prevent aortic disease. (massgeneral.org)
• 34-36 Moreover, the era of randomized clinical trials in aortic valve disease has finally begun. (ahajournals.org)
• The reader is provided with the most current and comprehensive insight into all fundamental and clinical aspects of aortic disease. (worldcat.org)
• Mr Waterworth has a special clinical interest in aortic valve and root disease, heart valve disease and intrathoracic aortic aneurysms. (jspubs.com)
• Conclusion: Patients with a quadricuspid aortic valve require careful clinical evaluation and close follow up. (scirp.org)
• Said Dr. Vijayakumar M. , Clinical Professor, Department of Cardiology, Amrita Institute of Medical Sciences, Kochi, "Aortic diseases account for a high number of heart-related deaths and health conditions. (amrita.edu)
• The bicuspid aortic valve is also associated with an aortopathy, in which ascending aortic root dilatation or aneurysm occurs, further complicating this clinical condition. (jaoa.org)

Left ventricle7

• In particular, the aortic valve controls the flow of oxygenated blood pumped out of the heart from the left ventricle into the aorta, the main artery leading to the rest of the body. (healthcentral.com)
• People who have long-term raised blood pressure have an increased risk of aortic valve disease (AVD) - problems with the valve that controls how blood is pumped from the left ventricle of the heart out into the main artery, the aorta. (eurekalert.org)
• The thoracic aorta begins where the left ventricle ends at the aortic valve and continues down through the chest. (harvard.edu)
• When it works properly, the aortic valve is a one-way valve that separates the left ventricle, the main pumping chamber of your heart, from your aorta, the main artery that carries oxygenated blood to your entire body. (utah.edu)
• When the aortic valve won't open all the way because it has narrowed or the cusps have calcified, your heart has to work harder to pump enough blood out of the left ventricle and into your aorta. (utah.edu)
• New perspectives of the disease now lead us to see the condition in terms of the response of the left ventricle and of systemic features, rather than just in terms of the valve area itself. (jaoa.org)
• New measures of aortic flow and the response of the left ventricle provide new insights into the treatment of patients with this condition. (jaoa.org)

Genetic19

• The foundation urges people with potential genetic risks to get tested for aortic disease. (healthline.com)
• Previous studies have determined that other types of MYH11 genetic alterations can cause thoracic aortic disease to be inherited in families. (redorbit.com)
• Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. (clinicaltrials.gov)
• Some individuals may have a predisposition to develop an aortic aneurysm and/or dissection even without having one of the genetic syndromes. (hoag.org)
• Several factors increase the risk of developing an aortic aneurysm or dissection, including environmental and genetic influences. (torrancememorial.org)
• Genetic factors also influence the risk to develop an aortic aneurysm or dissection. (torrancememorial.org)
• Each confers a high risk for disease, and genetic testing for these genes is now offered clinically. (ctsnet.org)
• and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. (ahajournals.org)
• 21 Also, an emerging body of literature is investigating how genetic factors might influence disease development. (ahajournals.org)
• Some people come to our Multidisciplinary Aorta Program because they have a genetic condition or other medical conditions that put them at greater risk for aortic disease. (henryford.com)
• Routine screening and genetic testing of the relatives of patients suffering from aortic diseases could save lives, new research has shown. (le.ac.uk)
• A research team led by the University of Leicester has published a new study in the Journal of the American Heart Association which shows that over 30% of relatives of patients suffering from thoracic aortic diseases (TAD) have an underlying genetic predisposition to developing an aortic disease themselves. (le.ac.uk)
• The study, which is part-funded by the British Heart Foundation, highlights the importance of routine imaging and genetic testing of relatives of patients affected by TAD in order to identify the diseases early. (le.ac.uk)
• This research shows that there is a significant cohort of up to 30% of patients, including many younger patients, in whom a genetic predisposition to Aortic Dissection can and should be detected through appropriate screening. (le.ac.uk)
• These patients need not only the management of their aortic condition but also comprehensive treatment by genetic specialists and ophthalmologists. (amrita.edu)
• Many genetic syndromes in children may be associated with aortic problems. (amrita.edu)
• This with genetic diseases like Marfan's, increasing incidence of hypertension, inflammatory disorders we are looking into an enormous number of potential patients in society which requires centers of excellence for treatment. (amrita.edu)
• In an accompanying editorial comment , Himanshu J. Patel, MD, FACC, writes that "the fundamental lack of knowledge regarding bicuspid aortic valve disease suggests that there is a need for a prospectively-collected, clinically-robust database to further evaluate the natural history and genetic underpinnings of this complex, heterogeneous pathology. (acc.org)
• These are diseases that can be inherited via a Mendelian genetic mechanism. (wikipedia.org)

Reversing aortic root1

• Recent studies have shown perindopril to be powerful in controlling and even reversing aortic root dilatation. (medhelp.org)

Endovascular Aortic Repair1

• In March 2014, a formerly healthy 60-year-old man underwent an elective endovascular aortic repair because of an infrarenal aortic aneurysm. (cdc.gov)

Undiagnosed aortic dissection1

• Ritter died at the age of 54 on September 11, 2003 from an undiagnosed aortic dissection. (healthline.com)

Thoracoabdominal Aortic Aneurysm2

• Descending thoracic and thoracoabdominal aortic aneurysm in patients with Takayasu's disease. (biomedsearch.com)
• From June 1974 to December 2001 we performed operative treatment on 33 patients with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease. (biomedsearch.com)

Calcification2

• The aortic valve is thickened and irregular and shows calcification and fusion of the cusps. (monash.edu)
• Even though the etiological mechanisms of the aortic valve disease and the coronary disease have been documented for many years, the relationship between these two pathological entities only started to be more sharply investigated in the beginning of the 90s after observations, conducted mainly with radiological images, of calcification in the coronary vasculature and in the aortic valve 7 , 8 . (scielo.br)

Progression6

• In this issue of the JCI, Li and colleagues introduce an unconventional concept by demonstrating that mTOR-dependent proliferative SMCs render the aortic wall vulnerable to dilatation and dissection rather than prevent disease progression. (jci.org)
• Prior research has suggested a link between LDL-C and aortic valve disease but randomized trials of cholesterol lowering performed in patients with advanced disease did not show any benefit in slowing the progression of valve disease," explains first author, Dr. J. Gustav Smith from the Department of Cardiology at Lund University. (eurekalert.org)
• Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression. (nih.gov)
• Mechanisms of action for non-coding RNAs during disease development and progression. (nih.gov)
• Diabetes is negatively associated with progression of abdominal aortic aneurysm (AAA). (ovid.com)
• Patients with diabetes and AAA disease might have decreased AAA progression if they switch to another oral antidiabetic or insulin. (ovid.com)

Patients with thoracic aortic diseases2

• The Barnes-Jewish & Washington University Heart & Vascular Center offers specialized care for patients with thoracic aortic diseases. (barnesjewish.org)
• Dr Giovanni Mariscalco, Associate Professor from the University of Leicester and Honorary Consultant Cardiothoracic Surgeon at Leicester's Hospitals, who led the study, said: "Our research identifies important knowledge gaps with respect to the predictive accuracy of commonly used screening tests across patients with thoracic aortic diseases. (le.ac.uk)

Wall of the aorta3

• In thoracic aortic disease, the wall of the aorta, the main blood vessel leading out of the heart, weakens and forms an aneurysm that can ultimately lead to an aortic dissection and death. (redorbit.com)
• Thoracic aortic aneurysms - bulges in the wall of the aorta - are more common than doctors had previously thought. (harvard.edu)
• Bleeding within the wall of the aorta, a variation of classic aortic dissection. (torrancememorial.org)

Causes of aortic1

• There are a variety of causes of aortic disease. (columbiasurgery.org)