Aortic Diseases: Pathological processes involving any part of the AORTA.Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Diagnostic Techniques, Cardiovascular: Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).Aorta: The main trunk of the systemic arteries.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.ElastinPostoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Magnetic Resonance Angiography: Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Contrast Media: Substances used to allow enhanced visualization of tissues.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Ehlers-Danlos Syndrome: A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. There are numerous subtypes: classical, hypermobility, vascular, and others. Common clinical features include hyperextensible skin and joints, skin fragility and reduced wound healing capability.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Natural Family Planning Methods: A class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature.Heart: The hollow, muscular organ that maintains the circulation of the blood.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Echocardiography, Transesophageal: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.Recovery Room: Hospital unit providing continuous monitoring of the patient following anesthesia.Hospital Mortality: A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.Length of Stay: The period of confinement of a patient to a hospital or other health facility.TexasInterior Design and Furnishings: The planning of the furnishings and decorations of an architectural interior.Cyclic GMP-Dependent Protein Kinases: A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.OhioMitral Valve Annuloplasty: A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).Mitral Valve: The valve between the left atrium and left ventricle of the heart.Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Heart Valve Prosthesis: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.

Endovascular stent graft repair of aortopulmonary fistula. (1/1622)

Two patients who had aortopulmonary fistula of postoperative origin with hemoptysis underwent successful repair by means of an endovascular stent graft procedure. One patient had undergone repeated thoracotomies two times, and the other one time to repair anastomotic aneurysms of the descending aorta after surgery for Takayasu's arteritis. A self-expanding stainless steel stent covered with a Dacron graft was inserted into the lesion through the external iliac or femoral artery. The patients recovered well, with no signs of infection or recurrent hemoptysis 8 months after the procedure. Endovascular stent grafting may be a therapeutic option for treating patients with aortopulmonary fistula.  (+info)

Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions. (2/1622)

The class A scavenger receptors (SR-As) are trimeric, integral membrane glycoproteins that exhibit unusually broad ligand-binding properties. A number of studies have suggested that these receptors may play an important role in host defense and in many macrophage-associated pathological processes, including atherosclerosis and Alzheimer's disease. The study of the expression and function of these receptors in human disease has been hampered by the lack of suitable antibodies recognizing human SR-A. This has generated questions regarding the nature of receptors responsible for scavenger receptor activity detected in a variety of cell types, including monocytes, macrophages, smooth muscle cells, and endothelial cells. To address these questions, we have produced high-titer antisera recognizing human SR-A by using mice deficient for SR-A (SR-A -/-). We show that SR-A -/- mice produce a significantly higher-titer immune response than do wild-type (SR-A +/+) littermates, with antisera of the former having a broad species reactivity and recognizing SR-A from humans, mice, and rabbits. The antisera recognize both type I and II SR-A in a wide range of immunological techniques. Using these antisera we show that the expression of SR-A protein is induced during monocyte to macrophage differentiation and that SR-A mediates 80% of the uptake of acetylated low density lipoprotein by human monocyte-derived macrophages. We also establish that human SR-A is expressed by tissue macrophages in liver and lung and by macrophage-derived foam cells within aortic atherosclerotic lesions, with little detectable expression by smooth muscle cells or aortic endothelium.  (+info)

Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. (3/1622)

Recent data suggest that the immune system is involved in atherogenesis. Thus, interest has been raised as to the possible antigens that could serve as the initiators of the immune reaction. In the current work, we studied the effects of immunization with recombinant heat shock protein-65 (HSP-65) and HSP-65-rich Mycobacterium tuberculosis (MT) on early atherogenesis in C57BL/6J mice fed either a normal chow diet or a high-cholesterol diet (HCD). A rapid, cellular immune response to HSP-65 was evident in mice immunized with HSP-65 or with MT but not in the animals immunized with phosphate-buffered saline (PBS) alone. Early atherosclerosis was significantly enhanced in HCD-fed mice immunized with HSP-65 (n=10; mean aortic lesion size, 45 417+/-9258 microm2) or MT (n=15; 66 350+/-6850 microm2) compared with PBS-injected (n=10; 10 028+/-3599 microm2) or nonimmunized (n=10; 9500+/-2120 microm2) mice. No fatty streak lesions were observed in mice fed a chow diet regardless of the immunization protocol applied. Immunohistochemical analysis of atherosclerotic lesions from the HSP-65- and MT-immunized mice revealed infiltration of CD4 lymphocytes compared with the relatively lymphocyte-poor lesions in the PBS-treated or nonimmunized mice. Direct immunofluorescence analysis of lesions from HSP-65- and MT-immunized mice fed an HCD exhibited extensive deposits of immunoglobulins compared with the fatty streaks in the other study groups, consistent with the larger and more advanced lesions found in the former 2 groups. This model, which supports the involvement of HSP-65 in atherogenesis, furnishes a valuable tool to study the role of the immune system in atherogenesis.  (+info)

Atherosclerotic aortic gangliosides enhance integrin-mediated platelet adhesion to collagen. (4/1622)

Gangliosides, sialic acid-containing glycosphingolipids, accumulate in atherosclerotic vessels. Their role in the pathogenesis of atherosclerosis is unknown. Gangliosides isolated from tumor cells promote collagen-stimulated platelet aggregation and ATP secretion and enhance platelet adhesion to immobilized collagen. These activities are all mediated by ganglioside effects on the platelet integrin collagen receptor alpha2beta1. Therefore, we hypothesized that gangliosides isolated from atherosclerotic plaques would enhance platelet adhesion to immobilized collagen, a major component of the subendothelial matrix of blood vessels. Furthermore, we questioned whether this effect of atherosclerotic gangliosides might play a role in the pathogenesis of atherosclerosis. To test this hypothesis, we isolated the gangliosides from postmortem aortas of patients with extensive atherosclerotic disease and examined their effects on platelet adhesion. Samples of aortic tissue taken from areas involved with atherosclerotic plaque demonstrated accumulation of gangliosides (64.9+/-6.5 nmol/g wet weight) compared with gangliosides isolated from control normal aortic tissue taken from children who died of noncardiac causes (NAGs; 21.1+/-6.4 nmol/g wet weight). Interestingly, samples of tissue taken from diseased aortas but from areas not involved with gross plaque formation also demonstrated ganglioside accumulation (47.6+/-12.8 nmol/g wet weight). Next, the activity of each of these gangliosides on platelet adhesion to immobilized type I collagen was studied. Atherosclerotic aortic gangliosides (AAGs) as well as those isolated from grossly unaffected areas of the same aorta (UAGs) both increased platelet adhesion compared with control NAGs (OD570, 0. 37+/-0.11 and 0.29+/-0.14 versus 0.16+/-0.07, respectively; P<0.01 and P<0.05, respectively). These OD570 values corresponded to 9x10(5), 8x10(4), and 6x10(3) platelets per well after preincubation with 5 micromol/L AAG, UAG, and NAG, respectively. Increased adhesion was observed after preincubation with as little as 0.5 micromol/L AAG, and maximal adhesion was seen at 2.5 micromol/L, with a plateau extending to the highest concentration tested, 10 micromol/L. The effect of AAGs on platelet adhesion to collagen was abrogated by incubation of treated platelets with F-17 anti-alpha2 monoclonal antibody (OD570, 0.13+/-0.02). Finally, the effects of the major individual gangliosides isolated from atherosclerotic tissues, GM3 and GD3, were tested. GM3 increased adhesion to collagen (OD570, 0.415+/-0.06) as did GD3 (0.31+/-0.08). Similar to that of AAGs, the effect of both molecules was blocked by F-17 (0. 09+/-0.04 and 0.13+/-0.06, respectively). These experiments demonstrate that accumulated atherosclerotic gangliosides promote platelet adhesion to collagen, the major component of the subendothelial matrix. Furthermore, this activity is mediated by an effect of the gangliosides on the collagen-binding integrin alpha2beta1. This activity may provide a mechanism for the development of platelet thrombi at sites where atherosclerotic gangliosides accumulate and help to explain the role of platelets in the process of atherosclerotic disease progression.  (+info)

ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. (5/1622)

Along with apolipoprotein (apo) E, which promotes cholesterol efflux from foam cells, apoA1-containing high density lipoprotein (HDL) is thought to facilitate the transport of cholesterol from lesions. This role for apoA1 was tested in vivo by lethally irradiating apoE-deficient and apoE- plus apoA1-deficient mice and reconstituting them with bone marrow cells isolated from wild-type (WT) mice. ApoE, but not apoA1, was synthesized by the transplanted bone marrow-derived cells. Therefore, this transplantation procedure generated apoE-deficient animals with atherosclerotic lesions that contained both apoE and apoA1 (E/A1 mice) and apoE-deficient animals with lesions that contained apoE but no apoA1 (E/A1o mice). As shown previously, the transplanted WT macrophage-derived apoE dramatically lowered the plasma hypercholesterolemia in both groups. On feeding with an atherogenic diet after transplantation, plasma cholesterol levels were raised in both groups of mice, but the levels in the E/A1 mice at 20 weeks were 2- to 3-fold higher than in E/A1o mice. Immunohistochemical staining verified that apoE was abundant in lesions of both groups, whereas apoA1 was detected in the lesions of E/A1 mice only. Despite a 2- to 3-fold lower total plasma cholesterol in the E/A1o mice, the free cholesterol recovered from isolated aortas was approximately 60% higher and the mean lesion area in serial sections of the aortic valves 45% larger. Therefore, apoA1 reduces free cholesterol accumulation in vivo in atherosclerotic lesions.  (+info)

Generation and characterization of human smooth muscle cell lines derived from atherosclerotic plaque. (6/1622)

The study of atherogenesis in humans has been restricted by the limited availability and brief in vitro life span of plaque smooth muscle cells (SMCs). We describe plaque SMC lines with extended life spans generated by the expression of the human papillomavirus (HPV)-16 E6 and E7 genes, which has been shown to extend the life span of normal adult human aortic SMCs. Resulting cell lines (pdSMC1A and 2) demonstrated at least 10-fold increases in life span; pdSMC1A became immortal. The SMC identity of both pdSMC lines was confirmed by SM22 mRNA expression. pdSMC2 were generally diploid but with various structural and numerical alterations; pdSMC1A demonstrated several chromosomal abnormalities, most commonly -Y, +7, -13, anomalies previously reported in both primary pdSMCs and atherosclerotic tissue. Confluent pdSMC2 appeared grossly similar to HPV-16 E6/E7-expressing normal adult aortic SMCs (AASMCs), exhibiting typical SMC morphology/growth patterns; pdSMC1A displayed irregular cell shape/organization with numerous mitotic figures. Dedifferentiation to a synthetic/proliferative phenotype has been hypothesized as a critical step in atherogenesis, because rat neonatal SMCs and adult intimal SMCs exhibit similar gene expression patterns. To confirm that our pdSMC lines likewise express this apparent plaque phenotype, osteopontin, platelet-derived growth factor B, and elastin mRNA levels were determined in pdSMC1A, pdSMC2, and AASMCs. However, no significant increases in osteopontin or platelet-derived growth factor B expression levels were observed in either pdSMC compared with AASMCs. pdSMC2 alone expressed high levels of elastin mRNA. Lower levels of SM22 mRNA in pdSMC1A suggested greater dedifferentiation and/or additional population doublings in pdSMC1A relative to pdSMC2. Both pdSMC lines (particularly 1A) demonstrated high message levels for matrix Gla protein, previously reported to be highly expressed by human neointimal SMCs in vitro. These results describe 2 novel plaque cell lines exhibiting various features of plaque SMC biology; pdSMC2 may represent an earlier plaque SMC phenotype, whereas pdSMC1A may be representative of cells comprising an advanced atherosclerotic lesion.  (+info)

Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. (7/1622)

Inflammation is a major feature of human atherosclerosis and is central to development and progression of the disease. A variety of proinflammatory cytokines are expressed in the atherosclerotic plaque and may modulate extracellular matrix remodeling, cell proliferation, and cell death. Little is known, however, about the expression and potential role of anti-inflammatory cytokines in human atherosclerosis. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine whose expression and potential effects in advanced human atherosclerotic plaques have not been evaluated. We studied 21 advanced human atherosclerotic plaques. IL-10 expression was analyzed by use of reverse transcription-polymerase chain reaction and immunohistochemical techniques. Inducible nitric oxide synthase expression was assessed by using immunohistochemistry, and cell death was determined by use of the TUNEL method. Reverse transcription-polymerase chain reaction identified IL-10 mRNA in 12 of 17 atherosclerotic plaques. Immunohistochemical staining of serial sections and double staining identified immunoreactive IL-10 mainly in macrophages, as well as in smooth muscle cells. Consistent with its anti-inflammatory properties, high levels of IL-10 expression were associated with significant decrease in inducible nitric oxide synthase expression (P<0.0001) and cell death (P<0. 0001). Hence, IL-10, a potent anti-inflammatory cytokine, is expressed in a substantial number of advanced human atherosclerotic plaques and might contribute to the modulation of the local inflammatory response and protect from excessive cell death in the plaque.  (+info)

Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. (8/1622)

BACKGROUND: Secoisolariciresinol diglucoside (SDG) is a plant lignan isolated from flaxseed. Lignans are platelet-activating factor-receptor antagonists that would inhibit the production of oxygen radicals by polymorphonuclear leukocytes. SDG is an antioxidant. Antioxidants studied thus far are known to reduce hypercholesterolemic atherosclerosis. The objective of this study was to determine the effect of SDG on various blood lipid and aortic tissue oxidative stress parameters and on the development of atherosclerosis in rabbits fed a high-cholesterol diet. METHODS AND RESULTS: Rabbits were assigned to 4 groups: group 1, control; group 2, SDG control (15 mg. kg body wt-1. d-1 PO); group 3, 1% cholesterol diet; and group 4, same as group 3 but with added SDG (15 mg. kg body wt-1. d-1 PO). Blood samples were collected before (time 0) and after 4 and 8 weeks of experimental diets for measurement of serum triglycerides, total cholesterol (TC), and LDL, HDL, and VLDL cholesterol (LDL-C, HDL-C, and VLDL-C). The aorta was removed at the end of the protocol for assessment of atherosclerotic plaques; malondialdehyde, an aortic tissue lipid peroxidation product; and aortic tissue chemiluminescence, a marker for antioxidant reserve. Serum TC, LDL-C, and the ratios LDL-C/HDL-C and TC/HDL-C increased in groups 3 and 4 compared with time 0, the increase being smaller in group 4 than in group 3. Serum HDL-C decreased in group 3 and increased in group 4 compared with time 0, but changes were lower in group 3 than in group 4. SDG reduced TC and LDL-C by 33% and 35%, respectively, at week 8 but increased HDL-C significantly, by>140%, as early as week 4. It also decreased TC/LDL-C and LDL-C/HDL-C ratios by approximately 64%. There was an increase in aortic malondialdehyde and chemiluminescence in group 3, and they were lower in group 4 than in group 3. SDG reduced hypercholesterolemic atherosclerosis by 73%. CONCLUSIONS: These results suggest that SDG reduced hypercholesterolemic atherosclerosis and that this effect was associated with a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve.  (+info)

Aims Intra-operative grading of atheromatous plaques in the ascending aorta by epiaortic ultrasound (EAU) and transesophageal echocardiography (TEE) in patients who have undergone CABG. Methods and results Sixty patients scheduled for elective CABG were prospectively enrolled to undergo intra-operative TEE and EAU ultrasound scanning of the ascending aorta. The ascending aorta was divided into three sections; proximal, middle and distal, and four segments; anterior, posterior, medial and lateral. Degree of atherosclerosis was graded according to a modified Montgomery scale. Epiaortic ultrasound was unable to provide images for a reliable assessment in 56 areas (7.7%; 56/720) vs 322 non-visualized areas by TEE (44.7%; 298/720) (p , 0.01). Out of 563 areas that scored ≥ 2, EAU visualized 379/720 areas (52.6%), whereas TEE visualized 184/720 areas (25.5%) (p , 0.01). EAU mean scores were significantly higher for the mid (p = 0.0001) and distal (p = 0.05) sections and for the posterior segment (p ...
In his presentation entitled "Acute Aortic Syndromes: New Insights from IRAD and GenTAC Registries", Dr. Eagle will review the latest in the approaches to diagnosis and treatment of acute aortic syndromes and thoracic aortic disease. In particular, new insights as to the underlying causes of aortic syndromes, the optimal use of biomarkers, and the evolving role of genetics as it relates to diagnosis and screening will be emphasized. In addition, recent advances in best medical and interventional therapy for thoracic aortic disease will be discussed. Finally, Dr. Eagle will discuss where translational and imaging research advances are likely to shape the future care for patients with or at risk for thoracic aortic disease. ...
TY - JOUR. T1 - Acute aortic syndromes. T2 - A second look at dual-phase CT. AU - Lovy, Andrew J.. AU - Rosenblum, Jessica K.. AU - Levsky, Jeffrey M.. AU - Godelman, Alla. AU - Zalta, Amin B.. AU - Jain, Vineet R.. AU - Haramati, Linda B.. PY - 2013/4. Y1 - 2013/4. N2 - OBJECTIVE. The purpose of this article is to assess the diagnostic performance of the unenhanced and contrast-enhanced phases separately in patients imaged with CT for suspected acute aortic syndromes. MATERIALS AND METHODS. All adults (n = 2868) presenting to our emergency department from January 1, 2006, through August 1, 2010, who underwent unenhanced and contrast-enhanced CT of the chest and abdomen for suspected acute aortic syndrome were retrospectively identified. Forty-five patients with acute aortic syndrome and 45 healthy control subjects comprised the study population (55 women; mean age, 61 ± 16 years). Unenhanced followed by contrast-enhanced CT angiography (CTA) images were reviewed. Contrastenhanced CTA ...
Looking for Aortic diseases? Find out information about Aortic diseases. primary artery of the circulatory system circulatory system, group of organs that transport blood and the substances it carries to and from all parts of the... Explanation of Aortic diseases
Acute aortic syndrome (AAS) describes a range of severe, painful, potentially life-threatening abnormalities of the aorta. These include aortic dissection, intramural thrombus, and penetrating atherosclerotic aortic ulcer. AAS can be caused by a lesion on the wall of the aorta that involves the tunica media, often in the descending aorta. It is possible for AAS to lead to acute coronary syndrome. The term was introduced in 2001. Causes can include aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer or a thoracic aneurysm that has become unstable. The potential causes of AAS are life-threatening and present with similar symptoms, making it difficult to distinguish the ultimate cause, though high resolution, high contrast computerised tomography can be used. The condition can be mimicked by a ruptured cyst of the pericardium, ruptured aortic aneurysm and acute coronary syndrome. Misdiagnosis is estimated at 39% and is associated with delays correct diagnosis and improper ...
eview article describes the imaging modalities contributing to the diagnosis of aortic atherosclerosis. All imaging modalities do contribute to diagnostic imaging; however only echo provides realtime imaging during the different phases of treatment. If conventional TEE imaging quality is insufficient, additional screening with modified TEE or epiaortic ultrasound is advised. Modified TEE with A-View has the advantage to be performed before surigcal incision, when changes in surgical management or a crossover to a nonsurgical management can still be considered.. Click on the picture to read the article.. ...
The SPARC study is the only large-scale, population-based TEE study performed to date. Study participants were sampled from the adult population residing in a well-defined geographic area, are relatively free of selection bias, and are representative of the general population.. The following study limitations should be noted. First, this was a cross-sectional study, one lacking prospective follow-up data. However, data relating aortic plaque morphology, C pneumoniaeserology, and inflammatory markers to future cardiovascular and cerebrovascular events will be available during long-term follow up of the study cohort.. Second, we examined the association between C pneumoniaeIgG antibody titers and aortic atherosclerosis, assuming that the presence of IgG titers beyond a certain threshold (i.e., titers ≥1:16) is indicative of chronic C pneumoniaeinfection (7). Moreover, we examined the association between various levels of antibody titers and aortic atherosclerosis (4,7)and excluded one subject ...
Topic: Stress management for patients with an Aortic Disease. Location: East Foustanellas Conference Rm (H2368), second floor. Details: Group sessions will take place on the 3rd Tuesday of every other month. Patients with a history of an aortic aneurysm, aortic surgery or aortic dissection and their family are welcome to attend.
Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The most common problem is an aortic aneurysm, a bulging out of the artery wall that stretches like a balloon under the pressure of bloo
Causes and diagnosis of medical symptom Abdominal aortic atherosclerosis with references to diagnosis, testing, and other symptoms.
BACKGROUND:Since aortic calcification has been shown to initiate in the lower zone of well-thickened plaques (LZP) adjacent to the aortic media of rabbits fed supplemental cholesterol diets, a restricted supply of serum ...
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the thickness of a garden hose and runs from your heart through your chest and abdomen, carryin
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the
Genetics. With facilities throughout Orange County, The Hoag Health Network offers diverse health care to patients in the area. Learn more!
The authors concluded that endovascular technology could be helpful in treating selected young patients with genetically triggered thoracic aortic disease. However, we should be caution evaluating results of this mid-term follow-up study. Most aortic surgeons support the idea of endovascular therapy of genetically triggered aortic disease, but only in case of already prosthetic replaced aortic segments corresponding to proximal and distal landing zones. Endovascular treatment of the native aorta in Marfan and Loeys-Dietz syndrome patients is not recommended due to high-risk of later endoleaks type I. Further research and long-term follow-up studies are necessary to identify patients with genetically triggered thoracic aortic disease who benefit from endovascular aortic repair and delineate contraindication for endovascular approach.. ...
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Penetrating Atherosclerotic Ulcer
Our experience suggest that nonsurgical repair may be an effective therapeutic option for patients with descending thoracic aortic diseases such as aneurysms, pseudoaneurysms, or dissections.. Aneurysm of descending thoracic aorta was the first thoracic aortic disease to be repaired by a stent graft endovascular procedure. Effectively thoracic aneurysm stent graft treatment has the longest and most established long term results.4-6 In the past, our management of descending thoracic aortic aneurysm was medical unless clinical and instrumental signs of rupture were evident and required immediate surgery. At the present time, indications for stent graft treatment are presence of an uncomplicated aneurysm and history of hypertension with chest discomfort, or signs of compression on surrounding organs, as well as a diameter ,6 cm or expansion ,5 mm per year. However, if a patient is considered to be a candidate for stent graft placement, several major factors have to be taken into account. The most ...
To present the early and midterm results of endovascular stent-graft repair in patients with infrarenal penetrating aortic ulcers (PAU). Between January 1997 and December 2009, 20 patients (17 men; median age 72 years, range 48-85) with PAU of
TY - JOUR. T1 - Different infarction patterns in patients with aortic atheroma compared to those with cardioembolism or large artery atherosclerosis. AU - Kim, Seung Woo. AU - Kim, Young Dae. AU - Chang, Hyuk Jae. AU - Hong, Geu Ru. AU - Shim, Chi Young. AU - Chung, Seok Jong. AU - Hong, Jin Yong. AU - Song, Tae Jin. AU - Song, Dongbeom. AU - Bang, Oh Young. AU - Heo, Ji Hoe. AU - Nam, Hyo Suk. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Aortic atheroma is a known cause of ischemic stroke. However, it is unclear whether ischemic stroke is caused by emboli from aortic atheroma or by accompanying atherosclerosis. In this study, we evaluated lesion patterns of patients with complex aortic plaque (CAP) to assume the underlying pathophysiology. Acute ischemic stroke patients who underwent transesophageal echocardiography were included. CAP was defined as a plaque in the proximal aorta ≥ 4 mm thick or with a mobile component. The diffusion-weighted imaging lesion patterns of patients with CAP were compared ...
DISCUSSION. It is known that the majority of thoracic aortic diseases are degenerative and occur in association with risk factors for atherosclerosis such as smoking, hypertension and hypercholesterolemia[10] and all of those had a high prevalence in our sample.. One of the factors that impact morbimortality after aortic interventions are neurologic events and progression of aortic disease[11]. TEVAR is a safe and effective procedure to treat both aneurysms and dissections involving the descending aorta with relative low risk[12,13]. The landing zone was soon extended proximally in order to treat more extensive segments of the aorta, reducing the morbimortality when compared with conventional techniques[14-16].. New totally endovascular techniques for treatment of complex aortic arch diseases are available and include stenting of the supra-aortic vessels (parallel techniques), fenestrated or branched endografts. Those are promising, but experience in aortic arch repair are very limited[17] and ...
In this study using a newly developed CNT-based micro-CT with cardiac and respiratory gating, we have successfully quantified calcification in the aortic arch plaques of living mice. CNT-based sources are able to achieve a 10 ms or better temporal resolution, not directly achievable using conventional thermionic sources. As a result, we were able to gate cardiac and respiratory motion in a straightforward manner, allowing simplified animal handling without the need for intubation.. Heart contraction causes movement of the vascular wall and thereby motion blur in the acquired image.9 In addition, because the R-wave interval at 600 beats per minute is 100 ms, errors of pulse control ,5 to 10 ms could result in significant additional blur of structures. One of the key advantages of our CNT-based micro-CT system is the ability to control the x-ray pulses to at least a microsecond level. Although in vivo imaging of arch calcification has already been reported in B6-apoE KO mice using a conventional ...
Diseases of the thoracic aorta are increasing in prevalence. In the UK, there has been a steady rise in admissions for thoracic aortic dissection (TAD) from 7.2 to 8.8 per 100 000 population over the last decade.1 At the same time, admissions for thoracic aortic aneurysms (TAA) have increased from 4.4 to 9.0 per 100 000. Thoracic aortic disease is deadly; most patients with TAA are likely to die of a complication attributable to their aneurysm, accounting for up to 47 000 deaths annually in the USA.2 TAD affecting the ascending aorta has a 30-day mortality of 25-50%.3 The increase in numbers of patients presenting with disease of the thoracic aorta is predominantly due to an increase in elderly patients, over 75 years of age.1 This means that the upward trend is likely to continue as the population ages, and that these patients are more likely to suffer from multiple additional comorbid conditions, presenting greater challenges for clinicians. In the face of this increasing problem, our ...
Aortic atheroma has been correlated with traditional cardiac risk factors, coronary, carotid, renal and peripheral atherosclerosis, and is probably a manifestation of generalized atherosclerosis. Aortic atheroma has also been shown to be associated with atrial fibrillation, aortic valve sclerosis, and other calcification of the fibrous skeleton of the heart. None of the previous studies have looked at the noninvasive prediction of aortic atheroma using the history and physical signs of cardiovascular disease. This would be a time and cost-effective bedside diagnostic tool that would be useful prior to cardiac surgery, cardiac catheterization, and workup of ischemic stroke patients, especially when transesophageal echocardiogram (TEE) is being considered for diagnosis but cannot be obtained due to previously mentioned reasons. Although physical examination of peripheral vascular disease is non-specific, a combination of physical examination signs increases the probability of generalized ...
The four major acute aortic syndromes are aortic rupture (discussed above), aortic dissection, intramural hematoma, and penetrating atherosclerotic ulcer. Aortic dissection is caused by a circumferential or, less frequently, transverse tear of the intima. It often occurs along the right lateral wall of the ascending aorta where the hydraulic shear stress is high. Another common site is the descending thoracic aorta just below the ligamentum arteriosum. The initiating event is either a primary intimal tear with secondary dissection into the media or a medial hemorrhage that dissects into and disrupts the intima. The pulsatile aortic flow then dissects along the elastic lamellar plates of the aorta and creates a false lumen. The dissection usually propagates distally down the descending aorta and into its major branches, but it may propagate proximally. Distal propagation may be limited by atherosclerotic plaque. In some cases, a secondary distal intimal disruption occurs, resulting in the reentry ...
Aortic diseases, What is a thoracic aortic aneurysm?,How is a thoracic aortic aneurysm diagnosed?Heart Care For You aim of providing comprehensive cardiac care solutions to the patients for Angioplasty Surgery, Bypass surgery, Cardiac surgery, Valve Surg
TY - JOUR. T1 - Preoperative Noncontrast Chest Computed Tomography Identifies Potential Aortic Emboli. AU - Lee, Richard. AU - Matsutani, Noriyuki. AU - Polimenakos, Anastasios C.. AU - Levers, Lorraine C.. AU - Lee, Michelle. AU - Johnson, Robert G.. PY - 2007/7/1. Y1 - 2007/7/1. N2 - Background: Intraoperative epiaortic scanning identifies aortic atheroma. Avoiding atheroma manipulation reduces cerebral vascular accidents (CVA). Unfortunately, epiaortic scanning can only be performed after the time of sternotomy. We sought to determine whether (1) preoperative noncontrast chest computed tomography (CT) identifies areas of aorta at risk for embolization in high-risk patients, and (2) operative strategies designed at the reduction of aortic manipulation of these areas can reduce permanent strokes. Methods: The rate of permanent strokes was examined at a single institution between two time periods using the χ2 method. From January 2002 through June 2003 (pre-CT) 230 patients underwent elective ...
Cleveland Clinic surgeons performed 850 descending throacic aorta repair procedures in the past five years. The majority of these were elective operations that involved an endovascular approach.. ...
The Aortic Program at OHSU is a regional resource for aortic emergency care as well as routine management of aortic disease. We collaborate with your local physician and hospital to treat conditions such as descending aortic dissections, chronic thoracic aortic disease and complicated vascular disease.
An estimated 60,000 Americans are walking around with time bombs in their chests called thoracic aortic aneurysms. At any time, their main chest artery could suddenly burst open, causing massive internal bleeding that is almost always fatal.. Its possible to repair the defect before the artery bursts, but traditional surgery is highly invasive. The operation typically requires an 18-inch incision, a week or two in the hospital and three to six months to recover. There are several major risks, including stroke and paralysis.. At Loyola University Hospital, an increasing number of patients are being treated with a device called a stent graft, which is inserted without opening the chest. Stent graft patients typically go home in a day or two, and recover fully in about two weeks.. At Loyolas Thoracic Aortic Disease Clinic, about 70 percent of patients who undergo surgery for aneurysms in the chest artery are receiving stent grafts rather than open chest surgery. "And as the technology evolves, we ...
Our cross-sectional study shows for the first time that higher sclerostin levels are associated independently with AD in T2DM patients. Secondly, high concentrations of sclerostin were associated with abnormal IMT, carotid plaques, and aortic calcifications in T2DM males. We found similar differences in T2DM females with abnormal IMT and aortic calcifications. Thirdly, we found a significant positive correlation among sclerostin levels, homocysteine, and IMT in T2DM patients, independently of sex.. The higher levels of sclerostin observed in T2DM patients with AD suggest a specific role of sclerostin in this process, confirming data from preclinical studies. Previous reports on the Wnt signaling antagonist sFRP (11,13) illustrated that its upregulation after injury was involved in healing and homeostasis of vascular tissue. In support of this hypothesis, data with the Wnt signaling agonist Dishevelled (Dvl) (23), which acts as a positive regulator of the Wnt pathway, showed that activation of ...
Our secondary outcomes are mean aortic wall thickness at the most diseased segment on FDG PET/ CT and vessel wall area on MRI at the most diseased segment, and we will perform analyses using a model including the same variables as above ...
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice.. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013. The abdominal aortic calcification score (AACS) was assessed using lateral lumbar X ray, and the ankle-brachial index (ABI) using a Doppler device.. RESULTS: The median AACS was 11 (range 0 - 24). In 58% of the patients, all 4 segments of the abdominal aorta showed deposits, while 19% of patients had no visible deposits (AACS 0). Ankle-brachial index was normal in 49%, low (, 0.9) in 17%, and high (, 1.3) in 34% of patients. Altogether 91 patients (37%) died during the median follow-up ...
TY - JOUR. T1 - Transesophageal echocardiography in the diagnosis of diseases of the thoracic aorta. T2 - Part 1. Aortic dissection, aortic intramural hematoma, and penetrating atherosclerotic ulcer of the aorta. AU - Willens, Howard J.. AU - Kessler, Kenneth M.. PY - 1999/1/1. Y1 - 1999/1/1. KW - Acute aortic syndrome. KW - Aortic dissection. KW - Aortic intramural hematoma. KW - Penetrating aortic ulcer. KW - Thoracic aorta. KW - Transesophageal echocardiography. UR - http://www.scopus.com/inward/record.url?scp=0033388643&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033388643&partnerID=8YFLogxK. U2 - 10.1378/chest.116.6.1772. DO - 10.1378/chest.116.6.1772. M3 - Article. C2 - 10593804. AN - SCOPUS:0033388643. VL - 116. SP - 1772. EP - 1779. JO - Chest. JF - Chest. SN - 0012-3692. IS - 6. ER - ...
Penetrating atherosclerotic ulcer is characterized by ulceration that penetrates through the elastic lamina into the media, and is associated with a variable amount of haematoma within the aortic wall. Haematoma formation may extend along the media, resulting in aortic dissection. In some cases, haematoma extension causes stretching of the weakened aortic wall, leading to the formation of a saccular aneurysm. Rupture is an eventual outcome. This entity has to be distinguished from atheromatous ulcers that are confined to the intima layer, aneurysms and classic aortic dissection. Although they typically involve the descending thoracic aorta (mostly the middle or distal portion), penetrating atherosclerotic ulcers can also involve the abdominal aorta and seldom are multiple. Typical CT features of penetrating ulcers include focal involvement with adjacent subintimal haematoma located beneath the frequently calcified and inwardly displaced intima, often associated with thickening or enhancement of ...
Posted By CCF CARDIO MD - MTR on September 01, 1998 at 11:51:15: In Reply to: Aortic Root Dilation posted by Jay on August 31, 1998 at 00:48:01: _____ Dear Jay, than...
This study was undertaken to analyze immediate and mid-term knitted Dacron graft dilation and to establish which parameters should be taken as a reference when aortic graft dilation is evaluated. A Dacron knitted microvel double velour vascular graft (Hemashield Gold) was implanted in 30 patients with aneurysmal (19 cases, 63%) or occlusive (11 cases, 37%) aortic disease. The stems of bifurcated prostheses (27 patients, 90%) and tube grafts (3 patients, 10%) were measured. The package sizing (labelled size) was compared with the external diameter measured intraoperatively with a slide caliper, prior to implantation and after complete clamp release. Additional measurements were obtained by ultrasound 1 and 6 months after implantation, and in 16 cases (53% of the patients) ultrasound and computed tomography (CT) were performed at the end of the first year. The means of the measurements were compared using Students t test for matched pairs. The statistical significance level was set at p values | 0.05.
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Open aortic surgery is employed for patients who have indications for abdominal aortic aneurysm (AAA) repair but unfavorable anatomy for endovascular aortic repair. Open aortic surgery is also necessary to manage aortic thrombosis or repair of aortic
The purpose of this study was to compare two non-contrast 2D techniques with the current contrast-enhanced MRI standard 3D technique for the routine assessment of thoracic aortic pathologies. One hund
Can someone help shed some light for me...Im a 31 year old male, 63 210lbs with a history of hypertension that is controlled using lopressor. Recent echo, which was a follow up from a previous one done 2.5 years ago, showed an aortic root measuring 4.1cm at the sinus of valsalva. The physician documented this as mildly dilated. This is an increase from 3.8cm in 2013. Valve is trileaflet with no regurgitation noted. I have a follow up appointment on the 21st with my cardiologist. My question is....is the term dilated and aneurysm the same thing ...
TY - JOUR. T1 - Ultrasonographic images of spontaneous intramural hematomas of the intestinal wall in two patients with congenital bleeding tendency. AU - Gamba, G.. AU - Carnevale Maffe, G.. AU - Mosconi, E.. AU - Tibaldi, A.. AU - Di Domenico, G.. AU - Frego, R.. PY - 1995. Y1 - 1995. UR - http://www.scopus.com/inward/record.url?scp=0029153167&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0029153167&partnerID=8YFLogxK. M3 - Article. VL - 80. SP - 388. EP - 389. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 4. ER - ...
With the advent of helical CT, the capability of noninvasive imaging of the thoracic aorta has been enhanced considerably. In this article, we describe the potential of helical CT using dual-slice technology to evaluate thoracic aortic diseases such
Background: Despite the successful development in cardiac surgery, cerebrovascular accidents (CVA) remain a devastating complication. Aortic atherosclerosis has been identified as a major risk factor for CVA. The present thesis addresses this question in relation to aortic manipulation during cardiac surgery, being divided into a clinical (I-II) and an experimental part (III-V).. Material and methods: Consecutive cardiac surgery cases (n=2641) were analyzed. Patients with CVA were extracted from a database designed to monitor clinical symptoms. Patient records were used to confirm clinical data and diagnosis. Subdivision was made into three groups: control subjects, immediate, and delayed CVA, being analyzed for neurological symptoms (I). Patients with CVA who also had been investigated with computer tomography (CT) (n=77) were further evaluated in terms of hemispheric and vascular distribution of lesions. The CT-findings were compared with CVA symptoms (II). An aortic perfusion model was ...
...HOUSTON (Nov. 18 2010) Discovery of a fifth gene defect and the ide...In both studies the investigators have identified alterations in the ... Both discoveries are more confirmation of the role that proper contra...In thoracic aortic disease the deterioration of the wall of the aorta...,UTHealth,discoveries,shed,more,light,on,deadly,thoracic,aortic,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
A method and device for occluding a patients ascending aorta, maintaining circulation of oxygenated blood in the patient and delivering cardioplegic fluid to arrest the patients heart. An aortic occlusion catheter has an occluding member for occluding the ascending aorta. The aortic occlusion catheter passes through a cannula. Delivery of oxygenated blood is accomplished through either the cannula or the aortic occlusion catheter.
Transesophageal MRI of human thoracic aortae demonstrate the feasibility of the technique in healthy volunteers (Fig. 2A)and among patients with aortic atherosclerosis (Fig. 2B-D). Figure 2C, Dshows the corresponding TEMRI and TEE images of the distal aortic arch in a 77-year-old male patient with remote stroke, depicting heterogeneous atherosclerotic thickening, and this illustrates differences in circumferential plaque extent by the two methods. Figure 2Eis a longitudinal slice through the descending thoracic aorta and a portion of the arch of a normal subject, demonstrating the nonuniform SNR of the device (9,12). The SNR decreases linearly with radial distance from the probe, but substantially maintains its SNR along much of its length. In practical terms, this property allows TEMRI at multiple longitudinal locations over ∼20 cm without the need for repositioning the device.. Maximum and minimum WTs were 3.5 ± 1.2 mm and 1.2 ± 0.8 mm by TEE, and 3.3 ± 1.5 mm and 1.0 ± 0.7 mm by TEMRI, ...
The epidemic of diabetes and obesity assailing Westernized societies threatens to interact with the prevalent, age-related incidence of aortic disease to increase macrovascular disease burden.3 Primary prevention strategies are critically important; however, as many as one-third of patients with T2DM may be unaware of their disorder-and vascular disease processes that threaten life, limb, and autonomy progress from the earliest phases of the dysmetabolic state.1,2 A better understanding of aortofemoral disease in T2DM is necessary to develop new strategies to address this burgeoning clinical need.. The Ldlr−/− mouse has emerged as one useful model for studying macrovascular injury in response to T2DM.17 When fed HFD, these mice become obese, with concomitant hyperglycemia and dyslipidemia.17 Unlike the Apoe−/− mouse-a model of atherosclerosis in the absence of hyperglycemia and obesity17 Ldlr−/− mice fed the HFD elaborate key features of metabolic syndrome.17 The relationships ...
TY - JOUR. T1 - Acute aortic intramural hematoma. T2 - An analysis from the international registry of acute aortic dissection. AU - Harris, Kevin M.. AU - Braverman, Alan C.. AU - Eagle, Kim A.. AU - Woznicki, Elise M.. AU - Pyeritz, Reed E.. AU - Myrmel, Truls. AU - Peterson, Mark D.. AU - Voehringer, Matthias. AU - Fattori, Rossella. AU - Januzzi, James L.. AU - Gilon, Dan. AU - Montgomery, Daniel G.. AU - Nienaber, Christoph A.. AU - Trimarchi, Santi. AU - Isselbacher, Eric M.. AU - Evangelista, Arturo. PY - 2012/9/11. Y1 - 2012/9/11. N2 - Background-Acute aortic intramural hematoma (IMH) is an important subgroup of aortic dissection, and controversy surrounds appropriate management. Methods and Results-Patients with acute aortic syndromes in the International Registry of Acute Aortic Dissection (1996-2011) were evaluated to examine differences between patients (based on the initial imaging test) with IMH or classic dissection (AD). Of 2830 patients, 178 had IMH (64 type A [42%], 90 type B ...
Eighty-seven percent of aortoesophageal fistulas (AEFs) [1] were the result of a thoracic aortic aneurysm, foreign body ingestion, or esophageal malignancy. The remaining cases of AEF were caused by surgical complication, esophageal reflux, traumatic false aneurysm, tuberculosis, corrosive esophagitis, congenital anomaly, instrumentation, or atherosclerotic disease. Only two cases of a penetrating atherosclerotic aortic ulcer rupturing into the thoracic esophagus have been reported [2] and ours is the second such report. Since the time Snyder et al [3] reported first survival of a case of aortoesophageal fistula due to a thoracic aortic aneurysm in 1983 few long time survivors have been reported. The triad of mid thoracic pain, sentinel arterial hemorrhage, and final exsanguination after a symptom free interval has been termed as Chiaris triad [4]. The latent interval between prodromal hemorrhage and exsanguination is unpredictable and ranges from 2 hours to 18 days (mean, 2 to 3 days) [5]. We ...
Acute aortic syndromes occur in the setting of chronic hypertension and other factors that lead to degeneration of the media of the aortic wall. Bicuspid aortic valve, Marfans syndrome, Ehlers-Danlos syndrome, and familial history of aortic dissection all predispose to aortic syndromes. Chronic cocaine or amphetamine use accelerates atherosclerosis, increasing the risk for dissection.7 Prior cardiac surgery is another risk factor for aortic dissection. All mechanisms involve weakening of the medial layer and intimal wall stress. Response to stress may include aortic dilation, aneurysm formation, development of a penetrating ulcer, intramural hemorrhage, aortic dissection, and aortic rupture. ...
Title: Propofol and Systemic Inflammatory Response in Abdominal Aortic Surgery. VOLUME: 5 ISSUE: 2. Author(s):Jose M. Rodriguez-Lopez and Francisco S. Lozano. Affiliation:Servicio de Anestesiologia,Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007,Salamanca, Spain.. Keywords:Propofol, Systemic inflammatory response, Aortic surgery, Aortic cross-clamping. Abstract: Abdominal aortic surgery is relatively common associated with considerable postoperative morbidity and mortality. The aortic cross-clamping for the implantation of a vascular prosthetic graft induces a systemic inflammatory response (SIR) because of an ischemia-reperfusion (IR) injury. In our experimental models we have reported that propofol anesthesia, compared with sevoflurane, after IR modulates SIR and this effect might result in renal protection. ...
At the Massachusetts General Hospital Fireman Vascular Center, our world-renowned research advances patient care in the field of aortic disease.
Results. The frequencies of -108T allele, which determine lower paraoxonase level, were similar in the groups of AAA (0.462) and AIOD (0.479) patients. The lower surgical repair age in patients in both groups was significantly associated with smoking and the higher levels of total cholesterol (TC), low density lipoprotein cholesterol (LDLC), and triglicerides (TG) and values of TC/HDLC. In the AAA group the same negative relation was noted with BMI index. The higher values of %HDLC display the protective effect on AAA/AIOD progression. In the AIOD group positive relations were also seen with HDLC/LDLC index and diabetes. Associations between high density lipoprotein cholesterol (HDLC) fraction and age of AIOD repair were stronger in -108T allele carriers. Age of AAA surgical repair was independently related to smoking and TG level, and age of AIOD surgical repair was independently related to smoking, diabetes and TC level. These effects were stronger in PON1-108CC homozygotes ...
Axillofemoral bypass is a surgical method used in patients with symptomatic aortoiliac occlusive disease. It is most frequently performed when endovascular options are not suitable.
in Acta Chirurgica Belgica (2008), 108(4), 393-9. OBJECTIVE: To determine postoperative and long-term outcome and assess the relevance of abdominal ultrasound (US) after surgery for abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease (AIOD ... [more ▼]. OBJECTIVE: To determine postoperative and long-term outcome and assess the relevance of abdominal ultrasound (US) after surgery for abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease (AIOD). METHODS: Records of 1704 consecutive patients having graft implantation from 1988 to 2000, either for AAA (n = 1144) or for AIOD (n = 560), were reviewed. In 2006, follow-up was 9180 patients-years for the AAA group and 5450 patients-years for the AIOD group. Among 1006 alive patients, 377 were invited randomly for US and clinical examination. RESULTS: Hospital death occurred in 99 patients (8.6%) of the AAA group (53% in ruptured and 2% in elective AAA), and in 18 patients of the AIOD group (3.2%). There were 581 late deaths, ...
porcelain aorta - stl file processed This file was created with democratiz3D. Automatically create 3D printable models from CT scans. Learn more. porcelain aorta, ct with contrast, scan, dicom, axial, thorax, heart, aorta, descending, ascending, porcelain, arch, bronchus, lung, pulmonary, trunk, arteries, great, vessels, calcification, ribs, chest Calcification of the thoracic aorta is often associated with valvular and coronary calcification, reflecting an underlying atherosclerotic process. It has been found to be associated with an increased rate of mortality and cardiovascular disease. Porcelain aorta (PA) is extensive calcification of the ascending aorta or aortic arch that can be completely or near completely circumferential. This entity is rare in the general population, but it has an increasing incidence in older patients and in patients with coronary artery disease (CAD) or aortic stenosis (AS). The clinical relevance is based on the fact that it can complicate surgical aortic valve ...
We believe that this patient had symptoms associated with her vasculitis during the months before admission. The aortic dissection may have explained her abdominal pain and diarrhoea (transient intestinal ischaemia) and was presumably responsible for compromised perfusion of the right kidney, which caused high renin, new onset hypertension. The left kidney was atrophic, suggesting longstanding renovascular disease, which had not caused hypertension before she developed aortic disease. Thus, an important lesson is that acute hypertension, in particular with signs of activation of the renin-angiotensin-aldosterone system (hypokalaemia, mild hyponatraemia, hyperreninaemia, strong blood pressure response to ACE inhibition or angiotensin receptor blockade), should trigger suspicion of aortic disease, especially in elderly people. Aortic dissection can present with few symptoms and be easily overlooked. Hypertension occurs in about half of patients with aortic dissection and may be caused by ...
BelSECT is the professional organisation for all Belgian perfusionists. Our aims are to develop the profession of perfusion in Belgium, to represent the members of our society towards the authorities and other private and public organisations, national and international.
Pierre‐Yves Courand, Helena Pereira, Costantino Del Giudice, Philippe Gosse, Matthieu Monge, Guillaume Bobrie, Pascal Delsart, Claire Mounier‐Vehier, Pierre Lantelme, Thierry Denolle, Caroline Dourmap, Jean Michel Halimi, Xavier Girerd, Patrick Rossignol, Faiez Zannad, Olivier Ormezzano, Bernard Vaisse, Daniel Herpin, Jean Ribstein, Beatrice Bouhanick, Jean‐Jacques Mourad, Emile Ferrari, Gilles Chatellier, Marc Sapoval, Arshid Azarine, Michel Azizi, the DENERHTN Investigators ...
Acute aortic occlusion is an emergent vascular condition not encountered routinely. Given its varied presentations, including neurovascular deficits and mimicking an acute abdomen, the diagnosis is often delayed causing increased morbidity and mortality. We present a case of acute abdominal aortic occlusion masquerading as sudden onset lower extremity pain and weakness in an 86-year-old female requiring emergent thrombectomy. This is only the second case report to discuss the use of point-of-care ultrasound to expedite diagnosis and management. ...
An abdominal aortic aneurysm can be repaired with endovascular repair or open surgery. Both methods involve placing an artificial graft inside the damaged artery.
An abdominal aortic aneurysm can be repaired with endovascular repair or open surgery. Both methods involve placing an artificial graft inside the damaged artery.
A compendium addressing endovascular surgery techniques and technology advancement in the diagnosis and management of aortic disease.
Study Flashcards On Ascending Aorta at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
I was diagnosed in 2012 with ascending aorta dialation of 4.1 cm. In 2013 no change. Finally went back to dr in 2017 and echo showed 4.3 cm. 2 months later dr made me have a chest scan which read 4.5 cm. which is correct? Echo or scan? Dr wants […]
enlarged aorta - MedHelps enlarged aorta Center for Information, Symptoms, Resources, Treatments and Tools for enlarged aorta. Find enlarged aorta information, treatments for enlarged aorta and enlarged aorta symptoms.
Penyakit Aneurisma Aorta - Aneurisma aorta atau aneurisme aorta merupakan pembengkakan pembuluh aorta perut atau pembesaran aorta, pembuluh darah utama yang menyalurkan darah ke tubuh pada level abdomen. Baca Juga [more…] ...
വിവരങ്ങൾ ക്രിയേറ്റീവ് കോമൺസ് ആട്രിബ്യൂഷൻ-ഷെയർഎലൈക്ക് അനുമതിപത്ര പ്രകാരം ലഭ്യമാണ്; മേൽ നിബന്ധനകൾ ഉണ്ടായേക്കാം. കൂടുതൽ വിവരങ്ങൾക്ക് ഉപയോഗനിബന്ധനകൾ കാണുക ...
The 3rd ISAC 2017 as the part of Indonesian Sciences Expo (ISE) 2017 will be held on October 23-24, 2017 at Balai Kartini Convention Center, Jl. Gatot Subroto Kav. 37 Jakarta, Indonesia, by carrying the theme, Applied Chemistry for A Better Sustainable Life This is the 3rd international scientific conference organized by Research Center for Chemistry, Indonesian Institute of Sciences (LIPI ...
High fat/high cholesterol diets exacerbate β-amyloidosis in mouse models of Alzheimers disease (AD). It has been impossible, however, to study the relationship between atherosclerosis and β-amyloidosis; in those models because such mice were on atherosclerosis-resistant genetic backgrounds. Here we report the establishment of AD model mice, B6Tg2576, that are prone to atherosclerosis. B6Tg2576 mice were produced by back-crossing Tg2576 mice, an AD mouse model overexpressing human amyloid β-protein precursor with the Swedish double mutation, to C57BL/6 mice, a strain susceptible to diet-induced atherosclerosis. An atherogenic diet induced aortic atherosclerosis and exacerbated cerebral β-amyloidosis in B6Tg2576 mice. Compared with age-matched non-transgenic littermates, B6Tg2576 mice developed significantly more diet-induced aortic atherosclerosis. Unexpectedly, normal diet-fed B6Tg2576 mice also developed fatty streak lesions (early atherosclerosis) in the aorta. The aortic atherosclerotic ...
Coronary and aortic calcifications inter-relationship in stable angina pectoris: A Coronary Disease Trial Investigating Outcome with Nifedipine GITS (ACTION)--Israeli spiral computed tomography substudy.
In patients with peripheral arterial disease, obstructing plaques caused by atherosclerotic occlusive disease commonly occur in the infrarenal aorta and iliac arteries. Atherosclerotic plaques may induce symptoms either by obstructing blood flow or by breaking apart and embolizing atherosclerotic and/or thrombotic debris to more distal blood ...
Primary aortoesophgeal fistulas (AEF) are a rare but life-threatening condition because of substantial hemorrhage, requiring fast treatment to ensure patient survival. We report a case of a 69-year-old male with diagnosis of squamous cell carcinoma of the esophagus who suffered an episode of hematemesis and hemorrhagic shock. Gastrointestinal (GI) endoscopy revealed an ulcerated lesion with pulsatile hemorrhage. CT-scan confirmed the diagnosis of AEF. A stent-graft was placed in the descending aorta to control bleeding, and 2 days later an esophageal stent was deployed to reduce risk of aortic graft infection. The patient was discharged 13 days after admission and had no other episode of GI bleeding in a 6-month follow-up period. TEVAR may be used as a palliative or bridge treatment of AEF.. ...
Background Aortic bifemoral bypass (or aortobifemoral bypass) is a surgical procedure performed in patients with atherosclerotic disease of the infrarenal aorta and iliac vessels (see the images below). Most patients who undergo this procedure have symptoms of claudication, impotence, and poorly healing ulcers.
TEE is highly accurate for the detection of acute aortic syndromes as a result of the close proximity of the esophagus to the thoracic aorta and its ability to visualize both ascending and descending aortas and parts of the arch with high spatial resolution in real time. TEE is performed with a 2.5 to 7.5 MHz transducer that is mounted at the end of a gastroscopic probe. Generally, TEE imaging of the aorta begins with the probe behind the left atrium, and the proximal 5 to 10 cm of the ascending aorta is visualized by scanning at a 120° imaging plane. By imaging at a 40° to 60° plane, TEE allows simultaneous short-axis visualization of the aortic cusps and the 3 sinuses. When evaluating the ascending aorta, artifactual echoes are often encountered, but a well-trained echocardiographer should be able to discriminate this from true dissection. A true dissection flap often displays random mobility, especially when the dissection is acute, whereas an artifact has a more rigid and fixed location ...
TEE is highly accurate for the detection of acute aortic syndromes as a result of the close proximity of the esophagus to the thoracic aorta and its ability to visualize both ascending and descending aortas and parts of the arch with high spatial resolution in real time. TEE is performed with a 2.5 to 7.5 MHz transducer that is mounted at the end of a gastroscopic probe. Generally, TEE imaging of the aorta begins with the probe behind the left atrium, and the proximal 5 to 10 cm of the ascending aorta is visualized by scanning at a 120° imaging plane. By imaging at a 40° to 60° plane, TEE allows simultaneous short-axis visualization of the aortic cusps and the 3 sinuses. When evaluating the ascending aorta, artifactual echoes are often encountered, but a well-trained echocardiographer should be able to discriminate this from true dissection. A true dissection flap often displays random mobility, especially when the dissection is acute, whereas an artifact has a more rigid and fixed location ...
Imaging of vascular calcification is increasingly used for cardiovascular screening purposes in asymptomatic patients. Coronary and aortic calcium deposits in the vascular wall have been shown to be related to atherosclerotic plaque burden. New imaging techniques with electron beam computed tomography (EBCT) and multi-slice computed tomography (MSCT), to measure the ... read more calcium content in the coronary arteries, are promising methods for clinical risk assessment. However, the rising costs of these emerging cardiac imaging techniques and the radiation exposure involved demand a more critical evaluation of already existing and less expensive technology. In this thesis we have investigated whether arterial calcifications that are frequently seen on mammograms may serve as a screening tool for atherosclerotic risk assessment in women. The simultaneous use of mammograms for screening on breast cancer and atherosclerotic disease could be very cost-effective. Based on our findings in two ...
Using a team approach, experts at the Henry Ford Multidisciplinary Aorta Program specialize in quick and accurate diagnosis of aortic diseases.
Enlargement of the ascending aorta indicates a weakening of the aortic wall, according to Cedars-Sinai. Often, an enlarged ascending aorta is diagnosed as an aneurysm....
Trejeeve Martyn is the author of this article in the Journal of Visualized Experiments: Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Increased levels of omega-3s may be associated with less aortic calcification among men in the general population, with the effects seemingly driven by DHA (docosahexaenoic acid), says a new study.
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In medicine, aortoiliac occlusive disease, also known as Leriches syndrome and Leriche syndrome, is a form of central artery disease involving the blockage of the abdominal aorta as it transitions into the common iliac arteries. Classically, it is described in male patients as a triad of the following signs and symptoms: claudication of the buttocks and thighs absent or decreased femoral pulses erectile dysfunction This combination is known as Leriche syndrome. However, any number of symptoms may present, depending on the distribution and severity of the disease, such as muscle atrophy, slow wound healing in the legs, and critical limb ischemia. Treatment involves revascularization typically using either angioplasty or a type of vascular bypass Kissing balloon angioplasty +/- stent, so named because the two common iliac stents touch each other in the distal aorta. Aorto-iliac bypass graft Axillary-bi-femoral and femoral-femoral bypass (sometimes abbreviated "ax-fem fem-fem") The condition was ...
Over recent years, an improved consensus has been established regarding diagnosis and management of type B aortic dissection (TBAD). Primary conservative medical treatment with antihypertensive agents in combination with close surveillance seems to be justified in TBAD, until complications such as aneurysmal expansion, rupture, or progression of the initial dissection ... read more occur. Several clinical and radiological predictors of aortic growth in uncomplicated TBAD patients have been identified and can be used to select patients at high-risk for aortic enlargement and rupture during follow-up. Those patients might benefit from closer surveillance or early endovascular intervention. Over recent decades, the management of thoracic aortic pathologies has evolved to include endovascular approaches next to conventional open aortic repair. Currently, thoracic endovascular aortic repair (TEVAR) is the preferred approach for patients presenting with complicated TBAD and other thoracic aortic ...
Otte G, Seebass J. Aortobronchial fistula causing hemoptysis in a patient with a Dacron aortic patch graft: report of a case. J Am Osteopath Assoc 1984;83(6):442. doi: https://doi.org/10.7556/jaoa.1984.83.6.442.. Download citation file:. ...
Diabetes increases mortality by two- to fourfold from atherosclerosis-related causes, including coronary artery disease, stroke, and peripheral artery disease (1). There is a paucity of population-based data on subclinical atherosclerotic disease in arterial beds other than the coronary arteries in persons with diabetes (2).. In the Jackson Heart Study (JHS), we examined the association of diabetes with abdominal aortic calcification (AAC) among African Americans. Among included individuals (n = 1,664), the mean age was 57 (± 11) years, 69% were female, and 18.3% had diabetes (based on fasting blood glucose [FBG], HbA1c, use of glucose-lowering medications, or physician diagnosis). The median AAC and coronary artery calcification (CAC) scores were 904.15 (interquartile range 0-1093.10) and 0 (0-96.19), respectively. The prevalence of any AAC or CAC was 69% and 49%, respectively. Individuals with diabetes were older, had higher BMI, had higher systolic blood pressure and prevalence of ...
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... : Current Techniques with Fenestrated, Branched and Parallel Stent-Grafts by Gustavo S. Oderich English | 9 Apr. 2017 | ISBN: 3319151
Magnetic resonance imaging (MRI) of aortic atherosclerosis can predict the risk of heart attacks and other cardiovascular events in otherwise healthy individuals, researchers at UT Southwestern Medical Center have found.
Six thousand participants, 200 published papers, two genes associated with fatty liver disease discovered, one breakthrough drug class - those impressive numbers add up to the Dallas Heart Study, a landmark investigation begun at UTSW 15 years ago.
Aortic surgery can be performed as an elective or emergency procedure. There are various reasons to choose to undergo surgery, which can improve current symptoms or prevent an emergency later. We perform more than 200 major aortic procedures each year at the Aortic Center, including at least 50 specific valve repairs. The majority of these are elective, with excellent outcomes. Elective Surgery Among those who choose to undergo elective surgery, most can return to normal life with a quality and length resembling those without aortic disease.
A total of 32 studies including 27 case-control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges g = 1.73, 95% CI (1.25-2.22), P , 0.001], with significant heterogeneity across studies (P , 0.001, I 2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26-2.08), P , 0.001], with no significant heterogeneity (P = 0.10, I 2 = 46.06%).. ...
Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high incidence of vascular morbidity and mortality in this population. A network of inhibitors work in concert to reduce mineralization risk in extra-osseous tissue. Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts with mineral ions to form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought to assess whether CPP fetuin-A levels were associated with procalcific factors and aortic stiffness in a cohort of patients with Stages 3 and 4 CKD.. ...
Focused on the pathophysiology, diagnosis and treatment of aortic aneurysms and dissections. This conference is designed for cardiovascular and thoracic surgeons, residents, perfusionists, ICU and OR nurses and those involved with the care of individuals with aortic disease
Are prostate calcifications a serious problem - Are prostate calcifications a serious problem? No. Prostate calcifications are very common and generally do not pose a problem. These are usually calcifications from prostate secretions within the prostate and do not indicate any specific problem.
Robert E. Tainsh is the author of this article in the Journal of Visualized Experiments: Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
During an abdominal aorta scan, the mobile technologist uses two types of ultrasound to systematically interrogate the entire length of the abdominal aorta. He
Dystrophic amyloid of the cardiac valves and atherosclerotic aorta has the same antigenicity (pages 85-86). Tadaaki Yokota, Hitoshi Okabayashi, Tokuhiro Ishihara, Mutsuo Takahashi, Takako Iwata, Yoshimi Yamashita, Alfonso-Tadaomi Miyamoto and Fumiya Uchino. Version of Record online: 12 DEC 2008 , DOI: 10.1111/j.1440-1827.1995.tb03383.x. ...
In this study, we found that inhibiting MMP activity is associated with decreased calcium accumulation in the arterial wall. We began our studies by using doxycycline, an antibiotic with known MMP-inhibiting properties, to demonstrate an association between decreased aortic gelatinase levels and reduced aortic calcification. To explore the importance of MMPs in arterial calcification more directly, we used the synthetic MMP-specific inhibitor GM6001 and were able to demonstrate that it decreased aortic calcification both in vitro and in vivo. These findings suggest that MMPs play an important role in arterial calcification, and further, that inhibiting MMP activity may prevent arterial calcification in the clinical setting.. The changes in arterial histology associated with hypervitaminosis D have been well characterized.27-29 Rats exposed to sublethal doses of vitamin D initially develop calcium phosphate crystals along the elastic laminae followed by spreading of calcification into the ...
SCVS 2018 Abstracts: Statins Reduce Mortality And Failure To Rescue after Myocardial Infarction Following Aortobifemoral Bypass In Aortoiliac Occlusive Disease Patients
TY - JOUR. T1 - The retroperitoneal, left flank approach to the supraceliac aorta for difficult and repeat aortic reconstructions. AU - Mills, Joseph L. AU - Fujitani, Roy M.. AU - Taylor, Spence M.. PY - 1991. Y1 - 1991. N2 - Between 1986 and 1990, 11 patients with relative or absolute contraindications to standard infrarenal reconstructions underwent supraceliac aortofemoral bypass. The operation was performed through a left-flank incision extended into the eleventh intercostal space with retroperitoneal and extrapleural dissection. Indications included multiple failed infrarenal reconstructions in four patients, previous removal of infected aortofemoral bypass graft with failure of extra-anatomic bypass in five patients, prior para-aortic lymph node dissection and radiotherapy in one patient, and aortic aneurysmal disease proximal to the renal arteries in one patient. Bypass conduits included either a bifurcated Dacron graft or a tube graft to the left femoral artery with a femorofemoral ...
Aortic calcification was demonstrated in experimental animal models of hyperhomocysteinemia. Mild hyperhomocysteinemia was associated with aortic calcification, suggesting a relationship between homocysteine (HCY) and the pathogenesis of aortic calcification. In the present study, the effect of HCY on vascular calcification was examined in calcifying and non-calcifying vascular smooth muscle cells (VSMCs). Cell calcification was induced by incubation of VSMCs with [ glycerophosphate. Proliferation of VSMCs was studied by cell counting, H-3-thymidine (H-3-TdR) and H-3-leucine (H-3-Leu) incorporation. Ca-45 accumulation, cell calcium content, and alkaline phosphatase (ALP) activity were measured as indices of calcification. The results showed that the proliferation of calcifying VSMCs, which was indicated by cell counting, H-3-TdR and H-3-Leu incorporation in calcifying VSMCs, was enhanced as compared with that of non-calcifying VSMCs. HCY promoted increases in cell number, H-3-TdR and H-3-Leu ...
torso: Aortic aneurysm *Abdominal aortic aneurysm. *Thoracic aortic aneurysm. *Aneurysm of sinus of Valsalva ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 827. ISBN 0-7216-2921-0.. ... Mondor's disease (also known as "Mondor's syndrome of superficial thrombophlebitis"[2]) is a rare condition which involves ... Patients with this disease often have abrupt onset of superficial pain, with possible swelling and redness of a limited area of ...
Milewicz DM, Dietz HC, Miller DC (March 2005). "Treatment of aortic disease in patients with Marfan syndrome". Circulation. 111 ... Aortic specific symptoms are closely related to excessive TGF-ß signalling in the aortic root wall.[22] TGF-ß antagonism via ... Aortic specific symptoms are closely related to excessive TGF-ß signalling in the aortic root wall.[22] TGF-ß antagonism via ... more specifically changes in the aortic wall and progressive aortic dilation.[22] Antagonism of TGF-ß also further reduced MFS ...
torso: Aortic aneurysm *Abdominal aortic aneurysm. *Thoracic aortic aneurysm. *Aneurysm of sinus of Valsalva ... Hypertensive kidney disease. Other names. Hypertensive nephrosclerosis (HN or HNS), hypertensive kidney disease, hypertensive ... "Epidemiology of Hypertensive Kidney Disease".. CS1 maint: uses authors parameter (link). *^ Rowe, D J; Bagga, H; Betts, P B ( ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It ...
"Validation of the murine aortic arch as a model to study human vascular diseases". Journal of Anatomy. 216 (5): 563-571. doi: ... In the spread of disease. Rats can serve as zoonotic vectors for certain pathogens and thus spread disease, such as bubonic ... "CDC - Diseases directly transmitted by rodents - Rodents". Centers for Disease Control. 2011-06-07. Archived from the original ... Another zoonotic disease linked to the rat is foot-and-mouth disease.[7] ...
MYH11 Aortic aneurysm, familial thoracic 6; 611788; ACTA2 Aortic valve disease; 109730; NOTCH1 Apert syndrome; 101200; FGFR2 ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
However, TIAs can result from emboli in calcific aortic disease and aortic coarctation. Spinal arteriovenous malformations ( ... Gradual onset diseases are more common (85-90% of all diseases leading to a diagnosis of malformation) and are usually due to ... Malformations can be recognised as part of an acute illness or gradual onset disease. In diseases such as subarachnoid ... Vascular myelopathy (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood ...
PMC 324936 . The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC) (1 ... "Imaging of thoracic aortic disease". The British Journal of Radiology. 84 (3): S338-S354. doi:10.1259/bjr/30655825. PMC 3473913 ... "2014 ESC Guidelines on the diagnosis and treatment of aortic diseases". European Heart Journal. 35 (41): 2873-2926. doi:10.1093 ... The diagnosis of aortic dissection can be made by visualization of the intimal flap and flow of contrast material in both the ...
Between 20% and 85% of patients are affected with this disease. Bicuspid aortic valve disease is a big contributor to cardiac ... Aortic coarctation and aortic stenosis are both forms of aortic narrowing. In terms of word root meanings, the names are not ... whereas aortic stenosis occurs in the aortic root, at or near the aortic valve. This naturally could present the question of ... All patients with unrepaired or repaired aortic coarctation require follow up in specialized Congenital Heart Disease centers.[ ...
He serves as the Director of the Yale Center for Thoracic Aortic Disease. He received his undergraduate degree with a triple ... He specializes and practises suspended animation on his patients "About the Director". Yale Center for Thoracic Aortic Disease ...
Patients referred for this procedure may have Coronary Artery Disease (CAD); aortic, mitral or tricuspid valve diseases; or ... Other centers that utilize the MICS CABG technique for coronary heart disease are the University of Ottawa Heart Center (ON, ... 92% of patients were free from angina and none of the participants experienced any aortic complications, repeat ... Coronary artery bypass Mitral valve repair Mitral valve replacement Aortic valve replacement Atrial septal defects Hybrid ...
Milan B, Josip K (November 1967). "Ocular manifestations of the aortic arch syndrome (pulseless disease; Takayasu's disease) ( ... Takayasu's arteritis (also known as Takayasu's disease, "aortic arch syndrome," "nonspecific aortoarteritis," and "pulseless ... Those with the disease often notice symptoms between 15 and 30 years of age. In the Western world, atherosclerosis is a more ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. American College of ...
Milewicz DM, Dietz HC, Miller DC (Mar 2005). "Treatment of aortic disease in patients with Marfan syndrome". Circulation. 111 ( ... Marfan Syndrome is a congenital disease that arises from a mutation in the FBN-1 gene. This leads to the malformation and ... This provides the explanation for the aortic aneurysms and prolapsed valves that are commonly associated with Marfan Syndrome. ... Whiteman P, Hutchinson S, Handford PA (2006). "Fibrillin-1 misfolding and disease". Antioxidants & Redox Signaling. 8 (3-4): ...
This disease typically involves the aortic and mitral valves. After reports of valvular heart disease and pulmonary ... Hutcheson, J. D.; Setola, V.; Roth, B. L.; Merryman, W. D. (2011). "Serotonin receptors and heart valve disease-It was meant 2B ... As of 1997, the FDA was continuing to receive reports of valvular heart disease in persons who had taken these drugs. ... Centers for Disease Control and Prevention (CDC) (1997). "Cardiac valvulopathy associated with exposure to fenfluramine or ...
Crohn's disease - Gastritis, gallstones, peptic ulcer, abdominal aortic aneurysm, constipation, irritable bowel syndrome, ... Incidence (rate of newly diagnosed cases of the disease during a specified period of time, e.g., one month or one year); Period ... Cause of the disease (if known). Try to separate from risk factors, although some overlap is common. ... Heart disease - Smoking; high blood pressure; high cholesterol; obesity; family history (genetics). Kata. opsional. ...
Aortic valve stenosis and mitral valve dysplasia are heart diseases. Diagnosis is made by colour doppler echocardiography ... Polycystic kidney disease (PKD) and Bull Terrier hereditary nephritis (BTHN) are autosomal dominant diseases. PKD is diagnosed ... PLL is a late onset disease which typically affects dogs between the ages of mid 2 and 7. Younger and older cases are known. ... Dogs with a score of .3 or below are considered clear of the disease. Clearing breeding stock prior to use ensures that progeny ...
Aortic stenosis is a disease of the heart valve in which the opening of the aortic valve is narrowed. Symptoms include exercise ... Höllmer, M.; Willesen, J. L.; Jensen, A. T.; Koch, J. (2008). "Aortic stenosis in the Dogue de Bordeaux". Journal of Small ... leading the authors to speculate that the disease is more severe in the Dogue than in other breeds. Another heart problem in ...
Dissection of the aortic arch is rare due to medial scarring. As a result of this advanced disease process, standard methods of ... If the disease progresses, syphilitic aortitis leads to an aortic aneurysm. Unlike atherosclerosis, which typically manifests ... This leads to narrowing of the lumen of the vasa vasorum, causing ischemic injury of the medial aortic arch and then finally ... Inflammatory involvement of tertiary syphilis begins at the adventitia of the aortic arch which progressively causes ...
"Impact of aortic stiffness on survival in end-stage renal disease". Circulation. 99 (18): 2434-9. doi:10.1161/01.CIR.99.18.2434 ... Blacher J, Asmar R, Djane S, London GM, Safar ME (May 1999). "Aortic pulse wave velocity as a marker of cardiovascular risk in ... May 2001). "Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients". ... Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG (October 2002). "Aortic pulse-wave velocity and its ...
In humans, mutations in Notch most often result in bicuspid aortic valve disease and calcification of the aortic valve. Bone ... Garg V. et al "Mutations in NOTCH1 cause aortic valve disease." Nature September 2005 437(7056) p 270 - 274. doi:10.1038/ ... The cardiac outflow tract is a temporary structure in the developing embryo that connects the ventricles with the aortic sac. ... Pompa J. L. and Epstein J. A. "Coordination tissue interactions: notch signalling in cardiac development and disease." ...
Notch1 is also associated with calcification of the aortic valve, the third most common cause of heart disease in adults.[20][ ... A congenital heart defect (CHD), also known as a congenital heart anomaly or congenital heart disease, is a problem in the ... For another member of the gene family, mutations in the Notch1 gene are associated with bicuspid aortic valve, a valve with two ... Hoffman JI, Kaplan S (June 2002). "The incidence of congenital heart disease". J. Am. Coll. Cardiol. 39 (12): 1890-900. doi: ...
1999). "Impact of Aortic Stiffness on Survival in End-Stage Renal Disease". Circulation. 99: 2434-2439. doi:10.1161/01.cir. ... Increased aortic PWV has been shown to predict cardiovascular, and in some cases all cause, mortality in individuals with end ... Typical values of PWV in the aorta range from approximately 5 m/s to >15 m/s. Measurement of aortic PWV provides some of the ... 2002). "Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance: An Integrated Index ...
The cause of death was "heart disease, aortic insufficiency, and probably myocarditis." Edmund Kirby Smith, the last surviving ... In April and May, the Confederates lost almost as many men to death by disease in Corinth as had been killed in battle at ...
Other causes include connective tissue diseases, hypothyroidism, aortic rupture, and following cardiac surgery. In Africa, ... aortic dissection. Is pericardiocentesis harmful?". Circulation. 90 (5): 2375-8. doi:10.1161/01.CIR.90.5.2375. PMID 7955196. ... and rarely occurs during retrograde aortic dissection, or while the person is taking anticoagulant therapy. The effusion can ...
... he suffered from narrowing of the aortic valve related to rheumatic heart disease. As Smithy began to operate on a series of ... By 1946, Smithy had devised what he called a valvulotome, which he used to cut away scar tissue from the aortic valve. He made ... On October 28, Smithy died; he had never been able to undergo surgery on his own aortic valve. An autopsy later showed that the ... In June 1948, Smithy sent Blalock a letter indicating that he had a young man from New York whose aortic stenosis was nearly ...
Single valve disease (aortic) treated with a two valve procedure (aortic and pulmonary). One of the main objections to the Ross ... Chambers J, Somerville J, Stone S, Ross D (1997). "Pulmonary autograft procedure for aortic valve disease: long-term results of ... procedure is the genesis of pulmonary valve disease in addition to aortic valve disease. Proponents have argued that biological ... Homografts (aortic or pulmonary) should be the replacement of choice; no other valve performed as well in the pulmonary ...
Heart Disease - the most common heart problems are aortic stenosis, mitral valve dysplasia, cardiomyopathy; Eyes Disease - the ... "Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) in Black Russian Terriers". Canine Genetic Diseases Network. Retrieved 19 ... however it is prone to certain hereditary diseases: Major concerns: Hip dysplasia Elbow dysplasia Hyperuricosuria Juvenile ... a nutritionally based developmental disease especially in young, heavy, fast-growing puppies; Panosteitis (Pano or Wandering ...
Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... and characterization of seven novel mutations of elastin gene in a cohort of patients affected by supravalvular aortic stenosis ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease». Gastroenterology. 139 (1): ...
Pulsus bisferiens: an unusual physical finding typically seen in patients with aortic valve diseases. If the aortic valve does ... such as aortic outflow tract obstruction, mitral stenosis, aortic arch syndrome) etc. A bounding pulse signifies high pulse ... unless there is coexisting aortic regurgitation). The delay can also be observed in supravalvar aortic stenosis. Several pulse ... It is seen in aortic valve stenosis. Pulsus paradoxus: a condition in which some heartbeats cannot be detected at the radial ...
In many patients, the disease remains undiagnosed until there is a devastating complication or fatal event, such as an aortic ... Ritter Rules for Aortic Diseases. http://www.ehlersdanlosnetwork.org/vascular.html. Accessed April 14, 2015.. 4. Pepin MG, ... and initiating genetic testing when the disease is suspected. Signs and Symptoms of Vascular EDS. The signs and symptoms of ... and N-termini or with those leading to haplo-insufficiency were found to have a milder course of the disease and less prevalent ...
Studies show that people with serious aortic stenosis, the most common type of heart valve disease in the elderly, have only a ... Heart Valve Disease Patient Councilghh_alan2020-03-17T17:52:37+00:00 Home / Patient Councils / Heart Valve Disease Patient ... Heart valve disease is caused by either wear, disease or damage of one or more of the hearts valves, affecting the flow of ... It is estimated that more than 1 in 8 people over the age of 75 suffer from moderate to severe heart valve disease, yet 3 out ...
Rupture of major vessels, including a ruptured aortic aneurysm (only in vascular EDS). • Rupture of a hollow organ such as the ... Inherited diseases of connective tissue. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders ... 2. Krakow D. Heritable diseases of connective tissue. In: Firestein GS, Budd RC, Harris ED Jr, et al, eds. Kelleys Textbook of ... Cardiac effects: Dysautonomia typically accompanied by Valvular heart disease (such as mitral valve prolapse, which creates an ...
Learn about aortic aneurysms, a balloon-like bulge in the aorta that can dissect or rupture. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People Centers for Disease Control ... Aortic aneurysms were the cause of 9,928 deaths in 2017.1. *About 60% of deaths due to aortic aneurysm or aortic dissection ... Abdominal Aortic Aneurysms An abdominal aortic aneurysm happens below the chest. Abdominal aortic aneurysms happen more often ...
Aortic diseases. Definition. Aortic diseases are pathological conditions affecting a section of the aorta, the largest artery ... Aortic diseases: FBN1 mutation affects survival in Marfan syndrome *Gregory B. Lim ... Patient-specific Computational Hemodynamic Analysis for Interrupted Aortic Arch in an Adult: Implications for Aortic Dissection ... Abdominal aortic aneurysm: update on pathogenesis and medical treatments This Review discusses the latest findings and current ...
... the aortic valve, one of the four valves in the heart. Description The most common valvular problem in old age is aortic valve ... Definition Aortic Valve Disease entails damage to, and dysfunction of, ... Aortic Valve Disease entails damage to, and dysfunction of, the aortic valve, one of the four valves in the heart. ... Aortic valve disease can be congenital, result from infection, occur as a result of rheumatic heart disease, result from the ...
values for the aortic root but not the other two. Both reports say an aortic root is normal all the way up to 3.7 cm so I am ... Aortic Root (M-Mode): 3.4cm Aortic Root (2-D): 3.54cm Sinotubular junction: 2.76cm Ascending Aorta: 2.64cm *The report states ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... The surgeons recently replaced my aortic valve and ascending aorta when the ascending aortic aneursym reached the size of 5.0. ...
Aortic disease kills more than 15,000 people every year in the United States. Heres what you need to know about this deadly ... A chest X-ray or EKG wont necessarily spot aortic problems.. A family history of aortic disease puts you at higher risk. There ... What is aortic disease?. Your aorta is the main vessel that transports blood away from the heart and sends it to the rest of ... Aortic Dissection Killed John Ritter... What His Widow Wants Everyone to Know About the Disease. Written by David Mills. on ...
Enlarged vs dilated aortic root. These two descriptive terms commonly appear on cardiac reports, and are often used ... There is no perfect aortic root size,but I would say if your aortic root does not change (,0.1cm) in the next 2 years and ... There is no perfect aortic root size,but I would say if a person has aortic root measuring 3.9 cm that does not change/increase ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ...
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active ... Animal Models of Calcific Aortic Valve Disease. Krista L. Sider,1 Mark C. Blaser,1 and Craig A. Simmons1,2,3 ...
The 12-fold increased risk for aortic disease associated with this duplication of this region of chromosome 16 is greater than ... Patients with thoracic aortic aneurysms that lead to acute aortic dissections are 12 times more likely to have duplications in ... UTHealth Researchers Link Chromosome Region To Thoracic Aortic Disease. by Sam Savage ... neuropsychiatic conditions and thoracic aortic disease.". This region of chromosome 16 (16p13.1) contains nine genes and the ...
Mitral valve disease, Aortic ulcer, Thoracic aortic aneurysm, Aortic dissection, Aortic valve disease, Coronary artery disease ... Aortic valve stenosis, Aortic aneurysm, Coronary artery disease, Heart disease, Mitral valve disease, Mitral valve prolapse, ... Transcatheter aortic valve replacement, ECMO, Aortic aneurysm, Aortic valve disease, Mitral valve disease, Coronary artery ... Aortic valve disease, Structural heart disease, Coronary artery disease, Heart valve disease ...
Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke: the French Study of Aortic Plaques ... Abdominal Aortic Aneurysm. Severe thoracic aortic plaque was found in twice as many patients with abdominal aortic aneurysm on ... Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med. 1994; 331: 1474-1479. ... was also significantly associated with aortic plaque on TEE.37 Aortic plaque was present in 86% of those with aortic valve ...
The evolving epidemiology of valvular aortic stenosis. The Tromsø Study Gry Wisthus Eveborn, Henrik Schirmer, Geir Heggelund, ... Drug-induced valvular heart disease Bernard Cosyns, Steven Droogmans, Raphael Rosenhek, Patrizio Lancellotti ... Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction Rafal ... Sudden cardiac arrest in adolescence: the case of ventricular fibrillation 11 years after presenting with Kawasakis disease ...
Midaortic pseudoaneurysm complicating extensive endovascular stenting of aortic disease.. Cutry AF1, Whitley D, Patterson RB. ... A 59-year-old man who had Leriche syndrome underwent bilateral iliac artery and infrarenal aortic stent placement at another ... This case illustrates a potential life-threatening complication of extensive stent placement for aortoiliac occlusive disease. ...
In thoracic aortic disease, the wall of the aorta, the main blood vessel leading out of the heart, weakens and forms an ... Researchers have now discovered nine different genes linked to familial thoracic aortic disease. Family members who have ... UTHealth Researchers Link PRKG1 Genetic Mutation To Thoracic Aortic Disease. by editor ... He was also found to have aortic root dilation and because of his family history of early thoracic aortic dissections at ...
R. V. Freeman and C. M. Otto, "Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment ... MicroRNA Expression Signature in Human Calcific Aortic Valve Disease. Hui Wang,1 Jing Shi,1 Beibei Li,1 Qiulian Zhou,2 ... N. M. Rajamannan, F. J. Evans, E. Aikawa et al., "Calcific aortic valve disease: not simply a degenerative process: a review ... G. Latsios, D. Tousoulis, E. Androulakis et al., "Monitoring calcific aortic valve disease: the role of biomarkers," Current ...
Proliferative, degradative smooth muscle cells promote aortic disease. Maarten Hulsmans1 and Matthias Nahrendorf1,2,3 1Center ... Traditionally, thoracic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in ... phenotype also worsens atherosclerotic disease and could thus be considered as a therapeutic target for diverse aortic diseases ... mTOR-dependent proliferative SMCs render the aortic wall vulnerable to dilatation and dissection rather than prevent disease ...
I had a double cath on 8/7 which showed a severe aortic st... ... I was born with bicuspid aortic valve disease. I say all this ... Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... Lyme Disease Multiple Sclerosis Parkinsons Disease Prostate Cancer ... I had a double cath on 8/7 which showed a severe aortic stenosis, as well as a twisted stent (I have 7 of them) in a vessel. ...
... including aortic valve regurgitation and aortic stenosis, how these diseases affect the heart, and common symptoms. ... ABOUT AORTIC VALVE DISEASE. A diagnosis of aortic valve disease means your aortic valve doesnt work properly. The aortic valve ... Aortic Regurgitation. Aortic valve regurgitation, or aortic insufficiency, occurs when the aortic valve does not close tightly ... There are two types of aortic valve disease - aortic regurgitation and aortic stenosis. ...
Surgery for Aortic and Peripheral Vascular Disease. Endovascular Treatment of Thoracic Aortic Disease. Four Years of Experience ... Endovascular Treatment of Thoracic Aortic Disease. Alessandro S. Bortone, Emanuela De Cillis, Donato DAgostino and Luigi de ... Endovascular Treatment of Thoracic Aortic Disease. Alessandro S. Bortone, Emanuela De Cillis, Donato DAgostino and Luigi de ... Moreover, we were not able to compare the groups because they had different aortic diseases. The high mortality rate of the ...
Could you have aortic valve disease? Find out here. ... Aortic valve disease is when the aortic valve between the left ... Aortic valve disease occurs when stenosis, regurgitation or, in really unlucky people, both cause the aortic valve not to work ... Aortic Valve Disease. 2008. (Oct. 13, 2008) http://www.mayoclinic.org/aortic-valve-disease/ ... An aortic valve that started off too narrow from birth also can lead to stenosis (called congenital aortic valve disease). ...
What is aortic valve disease? Eric Horlick: A normal aortic valve is between four to five centimetres square and all of the ... EH: The normal treatment for severe aortic valve disease is surgery - we take out the old aortic valve and sew in a new one. ... The average patient with aortic valve disease has a narrowed aortic valve, which puts them at tremendous risk. ... With aortic valve disease, the hearts flow is capped. Even if the "tap" is on full tilt, only a trickle of blood flows through ...
I have a bicuspid aortic valve and Im addicted to weightlifting and cardio exercises. Post Edited (bunan) : 7/2/2009 12:51:14 ... Is there any relation between strenuous exercise and aortic dissection? ... Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... if you have a bicuspid aortic valve, you have to be screened for ascending aortic aneurysm, because many times an aneurysm ...
This topic contains 8 study abstracts on Aortic Plaques indicating that the following substances may be helpful: Alcohol, ... Diseases : Aortic Plaques, Aortic Stenosis, Atherosclerosis, Endothelial Dysfunction, High Cholesterol, Intima Media Thickening ... Diseases : Aortic Plaques, Atherosclerosis, Intima Media Thickening Additional Keywords : Drug: Simvastatin, Food as Medicine, ... Diseases : Aortic Plaques, Intima Media Thickening Pharmacological Actions : Cardioprotective, Matrix metalloproteinase-2 (MMP- ...
  • It is estimated that more than 1 in 8 people over the age of 75 suffer from moderate to severe heart valve disease, yet 3 out of 4 people know little or nothing about the condition. (globalhearthub.org)
  • Although most investigators feel that aortic atherosclerosis is a leading cause of embolic disease, doubts have been raised. (ahajournals.org)
  • Ohyama Y, Ambale-Venkatesh B, Noda C et al (2017) Aortic arch pulse wave velocity assessed by magnetic resonance imaging as a predictor of incident cardiovascular events: the MESA (multi-ethnic study of atherosclerosis). (springer.com)
  • Aortic aneurysms are believed to be caused by the gradual weakening of the artery due to atherosclerosis, arterial narrowing and hardening from cholesterol plaque build-up. (imaginis.com)
  • Risk factors for TAD include poorly controlled high blood pressure, advancing age, male gender, atherosclerosis, inflammatory diseases that damage the blood vessels, and certain genetic conditions that weaken connective tissue, such as Marfan syndrome. (medicalxpress.com)
  • Objective- Calcific aortic valve disease is similar to atherosclerosis in that both diseases result from chronic inflammation and endothelial dysfunction. (ahajournals.org)
  • Abstract TP122: Are Aortic and Carotid Atherosclerosis Parallel or Divergently Associated with Cerebrovascular Disease in Systemic Lupus Erythematous? (ahajournals.org)
  • Aortic (Ao) and carotid (Ca) atherosclerosis (Athero) and cerebrovascular disease (CVD) are common and associated with high morbidity and mortality in systemic lupus erythematosus (SLE). (ahajournals.org)
  • Several studies show an association between AVS and presence of coronary artery disease. (scielo.br)
  • The aim of this study is to investigate the association between presence of AVS with occurrence of previous coronary artery disease and classical risk factors. (scielo.br)
  • We conclude that there is an association between presence of AVS with previous coronary artery disease and classical risk factors. (scielo.br)
  • The relationship between these two pathologies is explained by a progressive release in AVS of oxidized low-density lipoprotein that accumulates in the valves and extend through the coronary ostia towards the arteries where they are deposited, leading to coronary disease. (scielo.br)
  • This hypothesis is consistent with findings of histologic and immunohistochemistry studies and, even though the mechanism is not yet totally known, AVS can be used as a possible significant marker of obstructive coronary artery disease (CAD). (scielo.br)
  • Even though the etiological mechanisms of the aortic valve disease and the coronary disease have been documented for many years, the relationship between these two pathological entities only started to be more sharply investigated in the beginning of the 90s after observations, conducted mainly with radiological images, of calcification in the coronary vasculature and in the aortic valve 7 , 8 . (scielo.br)
  • 1 , 2 Increasingly, AS is the focus of interventional cardiologists who are typically performing fewer coronary angioplasty procedures and more percutaneous aortic valve replacement procedures. (jaoa.org)
  • We describe a technique of combined transcatheter aortic valve replacement (TAVR), off-pump single coronary artery bypass, and percutaneous coronary intervention (PCI) in a high-risk patient presenting with unstable angina and severe heart failure. (uwo.ca)
  • Coronary artery disease (CAD) is associated with abdominal aortic aneurysm in greater than 60% of cases. (jaoa.org)
  • Coronary and aortic calcifications inter-relationship in stable angina pectoris: A Coronary Disease Trial Investigating Outcome with Nifedipine GITS (ACTION)--Israeli spiral computed tomography substudy. (druglib.com)
  • BACKGROUND: Coronary heart disease and ischemic stroke are among the leading causes of morbidity and mortality in adults, and cerebrovascular disease is associated with the presence of symptomatic and asymptomatic CHD. (druglib.com)
  • Our expert team manages the complications of aortic valve disease using the latest advancements in medicine and repairs the valve using both traditional and minimally invasive techniques. (uclahealth.org)
  • Every year, between 50,000 and 90,000 adults in the U.S. die from vaccine-preventable infectious diseases or their complications. (silverbook.org)
  • Study population was extracted from the National Readmission Data (NRD) 2014 using International Classification of Diseases ninth (ICD-9) codes for TAVR, PVD and periprocedural complications. (onlinejacc.org)
  • Therefore, it seemed unlikely that the case was caused by complications of these diseases. (biomedcentral.com)
  • The foundation urges people with potential genetic risks to get tested for aortic disease. (healthline.com)
  • Previous studies have determined that other types of MYH11 genetic alterations can cause thoracic aortic disease to be inherited in families. (redorbit.com)
  • Certain genetic syndromes that affect connective tissue, including Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome vascular type and Turner syndrome, can greatly increase the risk of developing an aortic aneurysm. (hoag.org)
  • and (3) identification of cell-signaling pathways and genetic factors that may participate in valve disease pathogenesis. (ahajournals.org)
  • 21 Also, an emerging body of literature is investigating how genetic factors might influence disease development. (ahajournals.org)
  • Nonetheless, through a combination of epidemiological studies, histopathologic evaluation of human lesions, and genetic epidemiology, the past several years have seen rapid advances in our understanding of calcific aortic valve disease pathogenesis. (ahajournals.org)
  • Many genetic syndromes in children may be associated with aortic problems. (amrita.edu)
  • Other causes include hypertension (high blood pressure), Marfan syndrome (genetic connective tissue disease), infectious diseases such as syphilis or tuberculosis, or possibly a genetic predisposition in the case of abdominal aortic aneurysm. (imaginis.com)
  • In an accompanying editorial comment , Himanshu J. Patel, MD, FACC, writes that "the fundamental lack of knowledge regarding bicuspid aortic valve disease suggests that there is a need for a prospectively-collected, clinically-robust database to further evaluate the natural history and genetic underpinnings of this complex, heterogeneous pathology. (acc.org)
  • We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to a predisposing diet. (ahajournals.org)
  • These are diseases that can be inherited via a Mendelian genetic mechanism. (wikipedia.org)
  • Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. (hindawi.com)
  • These studies will be reviewed and organized into a proposed global hypothesis for the pathogenesis of calcific aortic valve disease. (ahajournals.org)
  • The lack of medical therapies for calcific aortic valve disease can be traced to at least two important issues, one intellectual, the other practical. (ahajournals.org)
  • The first was the long-held notion that calcific aortic valve disease was a "degenerative," and therefore unmodifiable, condition. (ahajournals.org)
  • 6 However, more recent studies have demonstrated convincingly that calcific aortic valve lesions have many features characteristic of an active pathobiological process, including chronic inflammation, 7-9 lipoprotein deposition, 10-12 active calcification, 13-18 and renin-angiotensin system activation. (ahajournals.org)
  • Only very recently has a purported mouse model of calcific aortic valve disease been described. (ahajournals.org)
  • Over the past several years, a number of risk factors for calcific aortic valve disease have been identified. (ahajournals.org)
  • The third presentation-the most common presentation-occurs because of calcific degeneration of an otherwise normal trileaflet aortic valve and typically presents in the seventh or eighth decade of life. (jaoa.org)
  • Calcific aortic valve disease is relatively common in the high-income countries, affecting between 4% and 5% of adults above the age of 75 years, and unless corrected, it carries significant morbidity and mortality. (bmj.com)
  • Heterozygous NOTCH 1 mutations have been associated to calcific aortic disease and a bicuspid aortic valve. (ahajournals.org)
  • After 16 weeks on the hyperlipidemic diet, calcific aortic disease was detected in heterozygous RBPJk mice. (ahajournals.org)
  • UAB Medicine's specialty-trained surgeons and physicians are leaders in their field and have excellent track records in treating some of the most complex aortic diseases and conditions. (uabmedicine.org)
  • To our knowledge, this case is the first illustrated report of typical rheumatoid nodules found in an aortic valve removed owing to aortic valve insufficiency in a patient with polyarticular JIA. (bmj.com)
  • However, because of its proximity to the aortic valve, it can often result in the development of aortic insufficiency. (pted.org)
  • In the case of Mr. Williams it is possible that he was born with an aortic valve that has two leaflets instead of the normal three, predisposing him to calcification at an earlier age (this is speculation on my part since the details of his case haven't been revealed). (everydayhealth.com)
  • Aortic valve sclerosis (AVS) is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. (scielo.br)
  • 0.05) was found between severity of CC and severity of aortic calcification (as measured by area, volume and slices of calcification). (druglib.com)
  • We're just starting to understand copy number variants and their link to disease," said Dianna Milewicz, M.D., Ph.D., senior author, professor and the President George H.W. Bush Chair in Cardiovascular Research, and director of the Division of Medical Genetics at The University of Texas Medical School at Houston, part of UTHealth. (redorbit.com)
  • E. E. Creemers, A. J. Tijsen, and Y. M. Pinto, "Circulating MicroRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? (hindawi.com)
  • Gamma-oryzanol has benefits in the treatment of cardiovascular disease. (greenmedinfo.com)
  • The study, published in the Journal of the American Medical Association ( JAMA ) and presented at the Canadian Cardiovascular Congress in Vancouver, could have major implications in the prevention of heart valve disease, a condition that currently has no known medical therapy. (eurekalert.org)
  • 38 In the Cardiovascular Health Study cohort, age, male gender, hypertension, and current smoking were correlated with the presence of echocardiographically-detected aortic sclerosis. (ahajournals.org)
  • At Henry Ford, we offer comprehensive aortic disease testing in our dedicated cardiovascular testing labs. (henryford.com)
  • Rawshani A, Rawshani A, Franzén S et al (2017) Mortality and cardiovascular disease in type 1 and type 2 diabetes. (springer.com)
  • Prince CT, Secrest AM, Mackey RH, Arena VC, Kingsley LA, Orchard TJ (2010) Pulse wave analysis and prevalent cardiovascular disease in type 1 diabetes. (springer.com)
  • Many conditions and cardiovascular diseases (including stroke) are better managed with regular exercise training. (centerwatch.com)
  • Approximately 85.6 million Americans suffer from some form of cardiovascular disease (CVD) and close to 1 in 3 deaths result from CVD. (silverbook.org)
  • Find out more about the Bicuspid Aortic Valve Program at Lurie Children's Hospital of Chicago, and the Cardiovascular Bridge Program, which assists young adults with the transition from pediatric to adult care. (nm.org)
  • Optimal pain management after aortic valve implantation: an opportunity to improve outcomes after transapical access in the future? (bmj.com)
  • Eric Horlick: A normal aortic valve is between four to five centimetres square and all of the blood that feeds the body passes through it. (thestar.com)
  • A normal aortic valve has three leaflets that open and close in sync with the heart's pumping to keep blood moving in one direction. (nm.org)
  • Your aortic valve normally has three snugly fitting, triangular leaflets (sometimes called cusps or flaps) attached to a ring of tissue called the annulus . (howstuffworks.com)
  • Sometimes, doctors can open a stenotic valve by inserting a catheter with a tiny balloon into the body, pushing it through a vein to the aortic valve and then expanding the balloon, knocking the leaflets fully apart. (howstuffworks.com)
  • In addition, people whose aortic valve has only two leaflets (bicuspid valve) instead of the normal three leaflets may be at increased risk for an aortic aneurysm. (medicalxpress.com)
  • Also, the valvuloplasty technique is not very effective in adults whose aortic valve leaflets have become calcified. (pted.org)
  • Sometimes during a person's fetal development, two of the three leaflets of the aortic valve fuse creating a bicuspid or two leaflet valve, instead of the normal tricuspid or three leaflet valve. (nm.org)