An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.
Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
Operative procedures for the treatment of vascular disorders.
Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.
A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Inflammation of the wall of the AORTA.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The plan and delineation of prostheses in general or a specific prosthesis.
Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.
Radiography of the vascular system of the brain after injection of a contrast medium.
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
Radiography of blood vessels after injection of a contrast medium.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Elements of limited time intervals, contributing to particular results or situations.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
Hand-held tools or implements used by health professionals for the performance of surgical tasks.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
An abnormal passage between two or more BLOOD VESSELS, between ARTERIES; VEINS; or between an artery and a vein.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Pathological processes involving any part of the AORTA.
Migration of a foreign body from its original location to some other location in the body.
The artery supplying nearly all the left half of the transverse colon, the whole of the descending colon, the sigmoid colon, and the greater part of the rectum. It is smaller than the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) and arises from the aorta above its bifurcation into the common iliac arteries.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.
The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.
The main trunk of the systemic arteries.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Use of a balloon CATHETER to block the flow of blood through an artery or vein.
Formation and development of a thrombus or blood clot in the blood vessel.
The main artery of the thigh, a continuation of the external iliac artery.
Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The period of confinement of a patient to a hospital or other health facility.
Either of two fleshy protuberances at the lower posterior section of the trunk or HIP in humans and primate on which a person or animal sits, consisting of gluteal MUSCLES and fat.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
An abnormal anatomical passage between the INTESTINE, and another segment of the intestine or other organs. External intestinal fistula is connected to the SKIN (enterocutaneous fistula). Internal intestinal fistula can be connected to a number of organs, such as STOMACH (gastrocolic fistula), the BILIARY TRACT (cholecystoduodenal fistula), or the URINARY BLADDER of the URINARY TRACT (colovesical fistula). Risk factors include inflammatory processes, cancer, radiation treatment, and surgical misadventures (MEDICAL ERRORS).
Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The act of constricting.
Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).
Surgery performed on the nervous system or its parts.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Incision into the side of the abdomen between the ribs and pelvis.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Methods of creating machines and devices.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.
Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.
Restoration of an organ or other structure to its original site.
A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.
The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Transducers that are activated by pressure changes, e.g., blood pressure.
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
Situations or conditions requiring immediate intervention to avoid serious adverse results.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
A synthetic tetracycline derivative with similar antimicrobial activity.
Surgical insertion of BLOOD VESSEL PROSTHESES, or transplanted BLOOD VESSELS, or other biological material to repair injured or diseased blood vessels.
Loss of blood during a surgical procedure.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Computer systems or networks designed to provide radiographic interpretive information.
A computer based method of simulating or analyzing the behavior of structures or components.
The arterial blood vessels supplying the CEREBRUM.
An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.
Application of a ligature to tie a vessel or strangulate a part.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Surgery performed on the heart or blood vessels.
Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Removal of an implanted therapeutic or prosthetic device.
Various branches of surgical practice limited to specialized areas.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The return of a sign, symptom, or disease after a remission.
Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.
Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Obstruction of flow in biological or prosthetic vascular grafts.
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
The performance of surgical procedures with the aid of a microscope.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Freedom of equipment from actual or potential hazards.
Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infection of MYCOBACTERIUM TUBERCULOSIS. Tuberculosis involvement may include the HEART; the BLOOD VESSELS; or the PERICARDIUM.
A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The first and largest artery branching from the aortic arch. It distributes blood to the right side of the head and neck and to the right arm.
Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Surgical incision into the chest wall.
Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.
Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Splitting of the vessel wall in the VERTEBRAL ARTERY. Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the vertebral artery, aneurysm formation, or THROMBOEMBOLISM. Vertebral artery dissection is often associated with TRAUMA and injuries to the head-neck region but can occur spontaneously.
The period following a surgical operation.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Procedures to cause the disintegration of THROMBI by physical interventions.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Abscess of the PSOAS MUSCLES resulting usually from disease of the lumbar vertebrae, with the pus descending into the muscle sheath. The infection is most commonly tuberculous or staphylococcal.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.
The outermost covering of organs, blood vessels, and other such structures in the body.

Repair of ruptured thoracoabdominal aortic aneurysm is worthwhile in selected cases. (1/1156)

INTRODUCTION: The risks and benefits of operating on patients with ruptured thoracoabdominal aortic aneurysm (TAAA) have not been defined. The aim of the present study is to report this unit's experience with operations performed for ruptured TAAA over a 10-year period. METHODS: Interrogation of a prospectively gathered computerised database. PATIENTS: Between 1 January 1983 and 30 June 1996, 188 consecutive patients with TAAA were operated on, of whom 23 (12%) were operated for rupture. RESULTS: There were nine survivors (40%). Patients whose preoperative systolic blood pressure remained above 100 mmHg were significantly more likely to survive (4/8 vs. 13/15, p = 0.03 by Fisher's exact test). Survival was also related to Crawford type: type I (two of three survived); II (none of six); III (two of six); and IV (five of eight). All non-type II, non-shocked patients survived operation. Survivors spent a median of 28 (range 10-66) postoperative days in hospital, of which a median of 6 (range 2-24) days were spent in the intensive care unit. Survivor morbidity comprised prolonged ventilation (> 5 days) (n = 3); tracheostomy (n = 1); and temporary haemofiltration (n = 2). No survivor developed paraplegia or required permanent dialysis. CONCLUSIONS: Patients in shock with a Crawford type II aneurysm have such a poor prognosis that intervention has to be questioned except in the most favourable of circumstances. However, patients with types I, III and IV who are not shocked on presentation can be salvaged and, where possible, should be transferred to a unit where appropriate expertise and facilities are available.  (+info)

Rupture of aortic aneurysm with right-sided haemothorax. (2/1156)

A 62-yr-old male with a history of high blood pressure was admitted for persistent dyspnoea and a right-sided pleural effusion, complicated by a recent episode of shock. There was no history of trauma and the patient denied any thoracic pain. A chest tube was inserted which released nonclotting bloody fluid. A thoracic computed tomographic scan of the chest revealed an aneurysm of the inferior third of the descending thoracic aorta. The patient underwent a successful prosthetic graft replacement. We emphasize that rupture of aortic aneurysms should be considered in the evaluation of spontaneous haemothorax even if it is right-sided and not associated with pain.  (+info)

The value of late computed tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm repair. (3/1156)

PURPOSE: The purpose of this study was to determine the prevalence of late arterial abnormalities after aortic aneurysm repair and thus to suggest a routine for postoperative radiologic follow-up examination and to establish reference criteria for endovascular repair. METHODS: Computed tomographic (CT) scan follow-up examination was obtained at 8 to 9 years after abdominal aortic aneurysm (AAA) repair on a cohort of patients enrolled in the Canadian Aneurysm Study. The original registry consisted of 680 patients who underwent repair of nonruptured AAA. When the request for CT scan follow-up examination was sent in 1994, 251 patients were alive and potentially available for CT scan follow-up examination and 94 patients agreed to undergo abdominal and thoracic CT scanning procedures. Each scan was interpreted independently by two vascular radiologists. RESULTS: For analysis, the aorta was divided into five defined segments and an aneurysm was defined as a more than 50% enlargement from the expected normal value as defined in the reporting standards for aneurysms. With this strict definition, 64.9% of patients had aneurysmal dilatation and the abnormality was considered as a possible indication for surgical repair in 13.8%. Of the 39 patients who underwent initial repair with a tube graft, 12 (30.8%) were found to have an iliac aneurysm and six of these aneurysms (15.4%) were of possible surgical significance. Graft dilatation was observed from the time of operation (median graft size of 18 mm) to a median size of 22 mm as measured by means of CT scanning at follow-up examination. Fluid or thrombus was seen around the graft in 28% of the cases, and bowel was believed to be intimately associated with the graft in 7%. CONCLUSION: Late follow-up CT scans after AAA repair often show vascular abnormalities. Most of these abnormalities are not clinically significant, but, in 13.8% of patients, the thoracic or abdominal aortic segment was aneurysmal and, in 15.4% of patients who underwent tube graft placement, one of the iliac arteries was significantly abnormal to warrant consideration for surgical repair. On the basis of these findings, a routine CT follow-up examination after 5 years is recommended. This study provides a population-based study for comparison with the results of endovascular repair.  (+info)

Endovascular repair of a descending thoracic aortic aneurysm: a tip for systemic pressure reduction. (4/1156)

A proposed technique for systemic pressure reduction during deployment of a stent graft was studied. A 67-year-old man, who had a descending thoracic aneurysm, was successfully treated with an endovascular procedure. An occluding balloon was introduced into the inferior vena cava (IVC) through the femoral vein. The balloon volume was manipulated with carbon dioxide gas to reduce the venous return, resulting in a transient and well-controlled hypotension. This IVC-occluding technique for systemic pressure reduction may be safe and convenient to minimize distal migration of stent grafts.  (+info)

Endovascular stent graft repair of aortopulmonary fistula. (5/1156)

Two patients who had aortopulmonary fistula of postoperative origin with hemoptysis underwent successful repair by means of an endovascular stent graft procedure. One patient had undergone repeated thoracotomies two times, and the other one time to repair anastomotic aneurysms of the descending aorta after surgery for Takayasu's arteritis. A self-expanding stainless steel stent covered with a Dacron graft was inserted into the lesion through the external iliac or femoral artery. The patients recovered well, with no signs of infection or recurrent hemoptysis 8 months after the procedure. Endovascular stent grafting may be a therapeutic option for treating patients with aortopulmonary fistula.  (+info)

Intraoperative transoesophageal echocardiography as an adjuvant to fluoroscopy during endovascular thoracic aortic repair. (6/1156)

OBJECTIVES: To define the utility of intraoperative transeophageal echocardiography (TEE) during endovascular thoracic aortic repair. DESIGN: Retrospective study. MATERIALS: Five patients underwent six transluminal endovascular stent-graft procedures for repair of thoracic aortic disease. METHODS: After induction of anaesthesia, a multiplane or biplane TEE probe was placed to obtain views of the diseased aorta. Both transverse and longitudinal planes of the aortic arch and descending thoracic aortic segments were imaged. The aortic pathology was confirmed by TEE and the proximal and distal extents of the intrathoracic lesion were defined. Doppler and colour-flow imaging was used to identify flow patterns through the aorta before and after stent-graft deployment. RESULTS: Visualisation and confirmation of the aortic pathology by ultrasonography was accomplished in all patients. TEE was able to confirm proper placement of the endograft relative to the aortic lesion after deployment and was able to confirm exclusion of blood flow into the aneurysm sacs. CONCLUSIONS: TEE may facilitate repair by confirming aortic pathology, identifying endograft placement, assessment of the adequacy of aneurysm sack isolation, as well as dynamic intraoperative cardiac assessment.  (+info)

The role of radial elastic properties in the development of aortic dissections. (7/1156)

PURPOSE: The response of the upper and lower thoracic aorta to radial tensile stresses was compared with the response to circumferential and longitudinal stresses to understand the role of tensile stress in the tearing phase of an aortic dissection. METHODS: Square tissue samples (1.6 by 1.6 cm) were cut from the upper and lower segments of six porcine thoracic aortas and were elongated in the radial direction with a tensile testing machine. The radial extensibility of the thoracic aorta was compared with adjacent tissue samples that were tested in tension in the circumferential and longitudinal directions based on Young's modulus (ie, the ratio of tensile stress to strain). RESULTS: The elastic properties of the thoracic aorta in the radial direction were markedly different from both the circumferential and longitudinal properties. The average Young's modulus (calculated immediately before failing) was significantly lower in the radial direction for both the upper and lower thoracic segments (61.4 +/- 4.3 kPa, SEM) than the Young's modulus of corresponding segments in the circumferential and longitudinal directions that were not tested to failure (151.1 +/- 8.6 kPa and 112.7 +/- 9.2 kPa, respectively; P <. 05). Sections 7 micrometer thick were collected from four samples obtained from one upper thoracic aorta that were strained at 0, 1.0, 2.5, and 4.0 and then stained either with Movat's pentachrome or with hematoxylin and eosin. Histological analysis of the samples stressed in the radial direction revealed that smooth muscle cells were torn loose from their attachments to each other and to adjacent elastin. CONCLUSION: Although the aorta normally functions under radial compressive stresses associated with lumen blood pressure, these results show that the aorta tears radially at a much lower value of stress than would have been predicted from previous studies that have reported longitudinal and circumferential Young's modulus. This could explain why dissections propagate readily once the initial tear occurs.  (+info)

Chronic aneurysm of the descending thoracic aorta presenting with right pleural effusion and left phrenic paralysis. (8/1156)

A 62-year-old man was admitted to the emergency department with chronic dysphagia and lower back pain. Chest radiography revealed a wide mediastinal shadow and an elevated left diaphragm, which proved to be secondary to left phrenic paralysis. The patient was diagnosed with an aneurysm of the descending thoracic aorta and was admitted to the hospital. After the patient was admitted, the aneurysm ruptured into the right chest. The patient underwent an emergency operation to replace the ruptured segment with a synthetic graft. Postoperative recovery and follow-up were uneventful. This report describes an unusual presentation of a thoracic aortic aneurysm. Hemidiaphragmatic paralysis caused by compression of the phrenic nerve is an unusual complication that, to our knowledge, has not been previously reported.  (+info)

TY - JOUR. T1 - Statistical shape analysis of ascending thoracic aortic aneurysm: Correlation between shape and biomechanical descriptors. AU - Agnese, Valentina. AU - Pasta, Salvatore. AU - Cosentino, Federica. AU - Pilato, Michele. AU - Bellavia, Diego. AU - Raffa, Giuseppe M.. AU - Gentile, Giovanni. AU - Agnese, Valentina. AU - Gentile, Giovanni. AU - Raffa, Giorgia Maria Giovanna. PY - 2020. Y1 - 2020. N2 - An ascending thoracic aortic aneurysm (ATAA) is a heterogeneous disease showing different patterns of aortic dilatation and valve morphologies, each with distinct clinical course. This study aimed to explore the aortic morphology and the associations between shape and function in a population of ATAA, while further assessing novel risk models of aortic surgery not based on aortic size. Shape variability of n = 106 patients with ATAA and different valve morphologies (i.e., bicuspid versus tricuspid aortic valve) was estimated by statistical shape analysis (SSA) to compute a mean aortic ...
TY - JOUR. T1 - Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage. AU - Fuchs, Ralph J.. AU - Lee, W. Anthony. AU - Seubert, Christoph N.. AU - Gelman, Simon. AU - Yeager, Anita. PY - 2003/2. Y1 - 2003/2. N2 - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an anesthetic technique that allows immediate postoperative evaluation of lower extremity neurologic function.. AB - We present a case of descending thoracic aortic aneurysm repair using an endovascular stent graft, complicated by postoperative paraplegia, which was successfully treated by placing a spinal drain. The case highlights the importance of the concept of collateral flow to the spinal cord and of choosing an ...
Thoracic aortic aneurysms occur in 3 to 4% of persons older than 65 years. The incidence of thoracic aneurysm is approximately 6 to 10 cases per 100,000 person years with the incidence of thoracic aneurysm rupture occurring in 3.5 per 100,000 persons. The average age of diagnosis is 69 years. The prevalence of thoracic aortic aneurysm is up to 4.2% of the general population without hypertension. Most thoracic aortic aneurysms occur in the ascending aorta or the aortic arch. Aneurysm rupture accounts for 60% of deaths. Degenerative aneurysm associated with advanced age most commonly seen. There is no difference between the incidence in males versus females. Arteriosclerosis is the most common cause of thoracic aneurysm involving the descending aorta and aortic arch. It is most common in older individuals with males affected more than females. The etiology of thoracic aortic aneurysm is dependent on the location of the aneurysm. Ascending thoracic aorta aneurysm can be caused by cystic medial ...
TY - JOUR. T1 - Aortobronchial fistula after endovascular stent graft repair of the thoracic aorta. AU - VonFricken, Kurt. AU - Karamanoukian, Hratch L.. AU - Ricci, Marco. AU - Taheri, Abe. AU - Bergsland, Jacob. AU - Salerno, Tomas A.. PY - 2000/10/30. Y1 - 2000/10/30. N2 - Endovascular stent graft repair of descending thoracic aortic aneurysms has been recently introduced as an alternative to conventional graft replacement of the diseased aorta. As experience with this new technique accumulates, complications may occur. We herein report the case of a patient in whom we observed distal migration with leak of an endovascular stent graft previously inserted in the descending thoracic aorta, associated with an aortobronchial fistula. The urgent surgical treatment undertaken, which consisted of graft replacement of the previously stented aorta, had a fatal outcome. (C) 2000 by The Society of Thoracic Surgeons.. AB - Endovascular stent graft repair of descending thoracic aortic aneurysms has been ...
Thoracic endovascular aneurysm repair (TEVAR) is a safe and effective procedure for the treatment of thoracic aortic aneurysms (TAAs).
Thoracoabdominal aortic aneurysm repair: current endovascular perspectives Nathan Orr, David Minion, Joseph L Bobadilla Vascular and Endovascular Surgery, Department of Surgery, University of Kentucky, Lexington, KY, USA Abstract: Thoracoabdominal aneurysms account for roughly 3% of identified aneurysms annually in the United States. Advancements in endovascular techniques and devices have broadened their application to these complex surgical problems. This paper will focus on the current state of endovascular thoracoabdominal aneurysm repair, including specific considerations in patient selection, operative planning, and perioperative complications. Both total endovascular and hybrid options will be considered. Keywords: thoracoabdominal aneurysm, thoracic aorta, TEVAR, endovascular surgery
PURPOSE: To present a technique for renal and visceral revascularization allowing complete endovascular treatment of a ruptured type IV thoracoabdominal aneurysm using devices already stocked in most centers performing endovascular aneurysm repair. TECHNIQUE: Open arterial access is obtained to both common femoral arteries and the left subclavian artery (LSA). Access to the visceral and renal arteries is obtained through separate 8-F sheaths for each visceral and renal branch. Both visceral arteries (celiac trunk and superior mesenteric artery) are accessed through 2 separate sheaths placed into the LSA, and both renal arteries are accessed through 2 separate sheaths placed into the left common femoral artery. Corresponding covered stents are introduced and positioned in the celiac trunk, superior mesenteric artery, and both renal arteries but not deployed. The aortic stent-graft is then introduced and deployed through the right common femoral artery. Once the aneurysm exclusion is completed, ...
The data presented here support the conclusion that heterozygous loss-of-function mutations in LOX, specifically variants that disrupt the catalytic activity or lead to haploinsufficiency, predispose to thoracic aortic aneurysms and acute aortic dissections. Overlapping syndromic features of Marfan syndrome, such as pectus deformities and striae, were reported in family members with LOX variants, but these features were not sufficient to meet diagnostic criteria for Marfan syndrome.13 Thoracic aortic aneurysms in these individuals are either aortic root aneurysms or fusiform aneurysms, involving both the aortic root and ascending aorta. Although mutation carriers died of ascending aortic dissections, there were no reports of aortic dissections with minimal enlargement of the ascending aorta. None of the affected individuals presented with descending thoracic aortic aneurysms or dissections. Interestingly, a bicuspid aortic valve was identified in 3 of 18 individuals with LOX mutations. It is ...
SCVS 2020 Abstracts: Single-stage Hybrid Repair Of A Thoracoabdominal Aortic Aneurysm Complicated By Chronic Type B Aortic Dissection And Kommerells Diverticulum Via Simultaneous Median Sternotomy And Laparotomy
Thoracoabdominal aortic aneurysms usually present in elderly patients with serious renal, pulmonary, cerebral, or cardiac comorbidities that pose a great challenge to the attending surgeon. Endovascular techniques for the treatment of thoracoabdominal aneurysms are not yet widely used due to limitations associated with them, such as spinal and visceral ischemia. An 87-year-old Caucasian man with a symptomatic Crawford type I thoracoabdominal aortic aneurysm was treated successfully with a long tube stent graft using endovascular techniques and without any complication in follow-up examinations. The stent was placed distal to the left subclavian artery, and proximal to the celiac axis. The use of endovascular stents for long segment thoracoabdominal aortic aneurysms needs to undergo clinical investigation to determine whether this procedure decreases morbidity and mortality rates.
TY - JOUR. T1 - Technical video of endovascular repair of chronic postdissection thoracoabdominal aortic aneurysm using a five-vessel preloaded fenestrated-branched stent graft. AU - Mirza, Aleem K.. AU - Tenorio, Emanuel R.. AU - Kärkkäinen, Jussi M.. AU - Ozbek, Pinar. AU - Oderich, Gustavo S.. PY - 2019/1. Y1 - 2019/1. N2 - Fenestrated-branched endovascular repair has been applied to treat chronic postdissection thoracoabdominal aortic aneurysms (TAAAs). We report a patient with diffuse postdissection aortic aneurysm involving the arch and thoracoabdominal aorta treated in a staged fashion with redo aortic arch repair using the frozen elephant trunk technique, followed by completion endovascular TAAA using preloaded guidewire system and a five-vessel fenestrated and branched stent graft. A technical video illustrates the use of onlay fusion and sequential catheterization with the preloaded guidewire system to facilitate TAAA repair.. AB - Fenestrated-branched endovascular repair has been ...
The aorta is the artery that carries oxygen-rich blood away from the heart and on to other arteries that distribute it throughout the body. A thoracic aortic aneurysm occurs when a balloon forms in a weakened area of the aorta wall within the chest cavity. The weakened vessel wall is often caused by atherosclerosis. Thoracic aneurysm may occur in three parts of the thoracic aorta: the ascending aorta, the descending aorta or the aortic arch. A minor thoracic aortic aneurysm may have little effect on an individual, but can also be life-threatening and fatal if it bursts and causes severe internal bleeding. Symptoms of thoracic aortic aneurysm may include:. ...
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Ascending thoracic aortic aneurysm (ATAA) is defined as a dilatation of the ascending aorta producing a cross sectional diameter more than 1.5 times its normal value; values between 1.1 and 1.5 are considered dilated or ectatic ascending aorta. Normal values have been established by different imaging techniques: echocardiography, computed tomography (CT) and magnetic resonance imaging (MRI)1-3 (table 1). Aneurysmal disease of the aorta is clinically important since, as the diameter of the aorta expands, linear wall stress increases, which in turn directly increases the risk of spontaneous aortic rupture-an event with extremely poor prognosis for the patient. Thoracic aortic aneurysms (TAAs) involve the ascending aorta most commonly (50%), followed by the descending aorta (40%), whereas arch aneurysms (10%) and thoraco-abdominal aneurysms (10%) occur less often. In 25% of patients with ATAA, concomitant abdominal aortic aneurysm is present. Anatomical distinction is important since the aetiology, ...
The main objective for treating thoracic aortic aneurysm is to prevent it from rupturing. Depending on your aneurysms size and location, your options are medical monitoring or surgery.. Medical Monitoring. This will include regular appointments with your doctor along with frequent imaging tests to check the size of your aneurysm and the rate at which it is growing. If you have other heart or arterial conditions, your doctor may prescribe medication to mitigate symptoms.. It is imperative to discontinue all use of tobacco products after being diagnosed with an aortic aneurysm.. Surgery. Surgery is usually the course of action for anyone with an aneurysm larger than about 5 cm (approximately 2.5 inches). The type of surgical procedure you receive depends on the size and location of your aneurysm and your condition.. The most common operations to repair thoracic aortic aneurysms are:. ...
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac ...
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac ...
Detailed information on thoracic aortic aneurysms, including description of a thoracic aortic aneurysm, causes, symptoms, diagnosis, treatment, and full-color anatomical illustrations
Aortic aneurysm repair is surgery to fix a weak and bulging section of the aorta. The aorta is the large blood vessel (artery) that carries blood from the heart through the chest and belly to the rest of the body. The doctor used a man-made tube (called a graft) to replace the weak section of your aorta in your chest.. You can expect the cut (incision) in your chest to be sore for a few weeks. If you have stitches or staples in your incision, the doctor will take these out 1 to 3 weeks after surgery.. You will feel more tired than usual for several weeks after surgery. You may be able to do many of your usual activities after 4 to 6 weeks. But you will probably need 2 to 3 months to fully recover.. Some people find that they feel sad or more emotional than usual while they are recovering after this surgery. This may last for up to 6 weeks after surgery. Talk with your doctor if your sadness continues or if you have concerns about how you are feeling. Treatment and other support can help you feel ...
If you have been diagnosed with thoracic aortic aneurysm, you may be a candidate for endovascular stent grafting. Medtronic stent grafts used to treat over 100,000 patients.
Authors report their experience with surgical treatment of descending thoracic aortic aneurysms using femoro-femoral by-pass for spinal protection. Between June 1976 and December 2001, 650 patients with thoracic aortic aneurysm were seen and in 170 of them the descending thoracic aorta was involved. Surgery was needed in 73 patients, among whom 34 had fusiform chronic aneurysm of thoracic aorta, with involvement of proximal abdominal aorta in 12 cases, and 27 had type B aortic dissection. Emergency surgical treatment was needed in 38 patients. Resection of the diseased aorta was performed in 71 patients, patch repair of the intimal tear in 2. Spinal protection was achieved with femoro-femoral by-pass in all cases. Nineteen cases (26.02%) of post-operative death were observed. There were four cases of lower limbs motor deficit reported, two in thoraco-abdominal aortic aneurysms, and two in patients with type B aortic dissection. Clinical experience shows that veno-arterial by-pass achieves low ...
TY - JOUR. T1 - Total arch replacement with endarterectomy of the ascending aorta in a patient with aortic arch aneurysm and porcelain aorta. AU - Shimizu, Hideyuki. AU - Miyaki, Yasuko. AU - Kaneko, Tsuyoshi. AU - Suzuki, Ryo. AU - Kudo, Mikihiko. AU - Yozu, Ryohei. PY - 2008/12/1. Y1 - 2008/12/1. N2 - We describe total arch replacement for aortic arch aneurysm with a severely calcified (porcelain) aorta. Cardiovascular surgery is challenging under such conditions because the calcified plate interferes with clamping, incising, and suturing of the aorta. We performed this surgery under hypothermic circulatory arrest with antegrade cerebral perfusion. Calcification manifested particularly in the ascending aorta and prevented the use of a needle. We exfoliated the calcified intimal plate using an elevator designed for hand surgery, and then covered both the inner and outer sides of the endarterectomized aorta with a strip of bovine pericardium to reinforce the anastomotic region and cover the ...
Results: Three of the patients presented with rupture and underwent emergency surgery. Two of the patients had type 1 and one had type 4 thoracoabdominal aortic aneurysm. Mortality occurred in three patients, two of which had undergone surgery due to rupture. One patient developed paraparesis in the postoperative period. Conclusions: Thoracoabdominal aortic aneurysm repair is a high-risk procedure requiring good surgical experience, a multidisciplinary approach, good anesthetic management and a cautious intensive care follow up.. Key words: Aortic aneurysm, thoracic; surgery; treatment outcome ...
Background and Goal of Study: Neurologic deficit is a devastating complication of thoracoabdominal aortic aneurysm repair (TAAAR) and is associated with a significant increase in both, morbidity and mortality. The purpose of this study was to identify predictors of neurologic deficit after TAAAR. Materials and Methods: The subjects for this study comprised 449 consecutive patients
Our experience suggest that nonsurgical repair may be an effective therapeutic option for patients with descending thoracic aortic diseases such as aneurysms, pseudoaneurysms, or dissections.. Aneurysm of descending thoracic aorta was the first thoracic aortic disease to be repaired by a stent graft endovascular procedure. Effectively thoracic aneurysm stent graft treatment has the longest and most established long term results.4-6 In the past, our management of descending thoracic aortic aneurysm was medical unless clinical and instrumental signs of rupture were evident and required immediate surgery. At the present time, indications for stent graft treatment are presence of an uncomplicated aneurysm and history of hypertension with chest discomfort, or signs of compression on surrounding organs, as well as a diameter ,6 cm or expansion ,5 mm per year. However, if a patient is considered to be a candidate for stent graft placement, several major factors have to be taken into account. The most ...
1999 (English)In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 17, no 3, 268-270 p.Article in journal (Refereed) Published ...
FLAGSTAFF, Ariz. - July 13, 2017 - W. L. Gore & Associates, Inc. (Gore) today announced the first patient implant of the GORE® TAG® Conformable Thoracic Stent Graft with ACTIVE CONTROL System after receiving CE Mark last month. The first implant was performed by Prof. Dr. med. Giovanni Torsello and Dr. med. Martin Austermann at St. Franziskus Hospital, Munster, Germany.. The thoracic endovascular aortic repair (TEVAR) device is the first to feature a new delivery system that provides the physician with controlled, staged deployment. The system optimizes accuracy, angulation, and apposition to treat etiologies of the descending thoracic aorta including aneurysms, transections, and acute and chronic Type B dissections. The new device will be formally launched in European regions later this year.. The GORE® ACTIVE CONTROL System enhances the exceptional conformability of the stent graft; facilitating the optimized wall apposition that the Conformable GORE® TAG® Device is renowned for even in ...
Free Online Library: Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease.(Disease/Disorder overview) by Mediators of Inflammation; Biological sciences Aortic aneurysm Aortic aneurysms Apoptosis Biological response modifiers Bone morphogenetic proteins Cardiovascular diseases Interferon T cells Transforming growth factors
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From thoracic aortic aneurysms (TAA) treatment to thoracic aortic traumas, Advanced Vascular Surgery provides a range of treatment options.
OBJECTIVE This study was undertaken to define matrix metalloproteinase (MMP) expression in the anterior and posterior wall of descending thoracic aortic aneurysms (TAAs) and correlate it with specific computed tomography (CT) image sites within the descending thoracic aorta. METHODS Serial CT images of patients with TAAs were compared with age- and gender-matched normal descending thoracic aortas at levels T4-T12. The mean circumference of the TAAs was 153 mm (n = 12) and 148 mm (n = 11) at T8 and T10, respectively, compared with 75 mm (n = 12) and 75 mm (n = 10) in controls (P | .001). Aortic tissue was collected from a separate set of eight patients undergoing descending TAA resection (processed | or =12 hours of excision) and six cadavers (processed | or =24 hours of death). Tissue collected between the intercostals arteries was defined as posterior wall, and directly opposite was the anterior wall. MMP-9 and MMP-2 messenger RNA (mRNA) extracted from aortic tissue was analyzed by quantitative real
Over recent years, an improved consensus has been established regarding diagnosis and management of type B aortic dissection (TBAD). Primary conservative medical treatment with antihypertensive agents in combination with close surveillance seems to be justified in TBAD, until complications such as aneurysmal expansion, rupture, or progression of the initial dissection ... read more occur. Several clinical and radiological predictors of aortic growth in uncomplicated TBAD patients have been identified and can be used to select patients at high-risk for aortic enlargement and rupture during follow-up. Those patients might benefit from closer surveillance or early endovascular intervention. Over recent decades, the management of thoracic aortic pathologies has evolved to include endovascular approaches next to conventional open aortic repair. Currently, thoracic endovascular aortic repair (TEVAR) is the preferred approach for patients presenting with complicated TBAD and other thoracic aortic ...
In the thoracic aorta, a diameter of 3 cm or greater is generally considered aneurysmal, although the average size of surgically corrected aneurysms is over 5cm. Thoracic aortic aneurysms (TAAs) can involve the aortic root, ascending aorta, arch, descending aorta, or a combination of these locations.
Surgical resection for thoracic aortic aneurysms is generally recommended when the aneurysms size is 5 centimeters or greater, according to Cleveland Clinic. Some surgeons also calculate the risk of...
Aortic aneurysm, familial thoracic (AAT) 3 (AAT3; MIM 610380), AAT4 (MIM 132900), AAT5 (MIM 608967), AAT6 (MIM 611788), AAT7 (MIM 613780), AAT8 (MIM 615436), AAT9 (MIM 616166), SMAD3 related AAT, TGFB2 related AAT and TGFB3 related AAT are dominantly inherited disorders.. AAT5 and AAT3 have been linked to mutations in the transforming growth factor ß receptor type I and II genes (TGFBR1 and TGFBR2). Patients may have aneurysms of the aorta and other arteries. TGFBR2 mutations are currently estimated to be responsible for 5% of familial thoracic aortic aneurysms and dissections (TAAD).. AAT4, thoracic aortic aneurysm and/or dissection with patent ductus arteriosus is caused by mutations in the myosin heavy chain 11 gene (MYH11). It is important to note that not all individuals with myosin heavy chain mutations appear to have dilated aortas. These individuals, though asymptomatic, display a low aortic compliance and distensibility due to a decrease in the elasticity of the aortic wall.. AAT6 is ...
Aortic aneurysm, familial thoracic (AAT) 3 (AAT3; MIM 610380), AAT4 (MIM 132900), AAT5 (MIM 608967), AAT6 (MIM 611788), AAT7 (MIM 613780), AAT8 (MIM 615436), AAT9 (MIM 616166), SMAD3 related AAT, TGFB2 related AAT and TGFB3 related AAT are dominantly inherited disorders.. AAT5 and AAT3 have been linked to mutations in the transforming growth factor ß receptor type I and II genes (TGFBR1 and TGFBR2). Patients may have aneurysms of the aorta and other arteries. TGFBR2 mutations are currently estimated to be responsible for 5% of familial thoracic aortic aneurysms and dissections (TAAD).. AAT4, thoracic aortic aneurysm and/or dissection with patent ductus arteriosus is caused by mutations in the myosin heavy chain 11 gene (MYH11). It is important to note that not all individuals with myosin heavy chain mutations appear to have dilated aortas. These individuals, though asymptomatic, display a low aortic compliance and distensibility due to a decrease in the elasticity of the aortic wall.. AAT6 is ...
thoracic aortic aneurysms are less common than AAA descending thoracic aorta is the second most common location (after ascending aorta) there is a wide range of causes
Thoracic Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Background Compression of the trachea, bronchi, and pulmonary arteries are complications in patients with large thoracic aortic aneurysms. In this case, we report unexpected cardiopulmonary collapse...
Read about the types of thoracic aortic aneurysms and their common symptoms. UPMC offers various treatments and repair surgeries based on your condition.
A newer approach, called an endovascular repair, involves the use of a catheter that is inserted into the groin, in a similar fashion as an aortogram - however, the catheter is used to insert a self-expanding stent graft into the aneurysm. Endovascular repair of aneurysms does not require a large incision, and has a substantially shorter recovery than the conventional open surgical approach. Not all aneurysms are suitable for endovascular repair; however, vascular surgeons at UCSF Medical Center are experts in the treatment of aneurysms using both the conventional and the endovascular approach.. UCSF Medical Center has extensive experience in surgery for complex aortic aneurysms - those that involve the arteries to the kidneys or intestines - and is recognized as having one of the lowest mortality rates reported to date.. Similarly, our vascular surgeons pioneered endovascular repair of aneurysms, particularly those involving the aorta in the upper abdomen where blood vessels branch off to the ...
The first round began with Crawford illustrating a decided speed advantage over Burns, landing a sizzling left hook to midway through the round, while Burns landed a long right and made good use of his jab. Burns may have taken the first round. He is keeping Crawford off-balance. Crawford is not lighting the world on fire, keeping a low workrate and taking a while to warm up to the task, while the busier Burns takes advantage. Crawford did very little in the second stanza.. Having possibly already fallen into a hole, Crawford continued moving slickly, but not nearly moving his hands fast enough in the third. Burns showed a better workrate, giving the impression of being the harder-working fighter. Crawford may have a strategy in mind, but his subdued approach was somewhat mystifying, despite the rounds being close. Close doesnt get it done in Scotland against a domestic world champ, as we have seen before.. In the 4th, Crawford sprung to life with a prolonged barrage that seemed to have Burns ...
Diseases of the thoracic aorta are increasing in prevalence. In the UK, there has been a steady rise in admissions for thoracic aortic dissection (TAD) from 7.2 to 8.8 per 100 000 population over the last decade.1 At the same time, admissions for thoracic aortic aneurysms (TAA) have increased from 4.4 to 9.0 per 100 000. Thoracic aortic disease is deadly; most patients with TAA are likely to die of a complication attributable to their aneurysm, accounting for up to 47 000 deaths annually in the USA.2 TAD affecting the ascending aorta has a 30-day mortality of 25-50%.3 The increase in numbers of patients presenting with disease of the thoracic aorta is predominantly due to an increase in elderly patients, over 75 years of age.1 This means that the upward trend is likely to continue as the population ages, and that these patients are more likely to suffer from multiple additional comorbid conditions, presenting greater challenges for clinicians. In the face of this increasing problem, our ...
TY - JOUR. T1 - Patologia estesa dellaorta toracica. T2 - Trattamento ibrido con la tecnica del frozen elephant trunk. AU - Di Eusanio, Marco. AU - Armaro, Alessandro. AU - Di Marco, Luca. AU - Pacini, Davide. AU - Pantaleo, Antonio. AU - Di Bartolomeo, Roberto. PY - 2011/6. Y1 - 2011/6. N2 - Background. Aneurysms of the aortic arch extending beyond the origin of the left subclavian artery represent a challenging pathology in aortic surgery and, most commonly, are treated with different surgical, endovascular or hybrid two-staged procedures. In 2006, we initiated an intense surgical program with the frozen elephant trunk procedure that, combining together conventional surgery with endovascular techniques, allows single-stage treatment of patients with extended disease of the thoracic aorta. We here describe our surgical technique and the results with the single-stage frozen elephant trunk procedure. Methods. Between January 2007 and August 2010, 87 patients were treated with the frozen elephant ...
McKellar S.H., Tester D.J., Yagubyan M., Majumdar R., Ackerman M.J., Sundt T.M.. OBJECTIVES: Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection. Patient-specific prediction of the risk of developing thoracic aortic aneurysm, however, is imprecise. We hypothesize that genotypic variations in patients with bicuspid aortic valves contribute to this observed variability in aortic phenotype. We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. METHODS: We performed a targeted mutational analysis of NOTCH1 using genomic DNA from 48 unrelated subjects with concomitant bicuspid aortic valve and thoracic aortic aneurysm using denaturing high-performance liquid ...
Previous genetic studies of patients with thoracic aortic aneurysms have identified mutations in several genes involvedin some way with transforming growth factor (TGF)-β signaling: FBN1 (encoding fibrillin-1, causing Marfan syndrome), TGFBR1 and TGFBR2 (encoding transforming growth factor-β receptors I and II, causing Loeys-Dietz syndrome), and SMAD3 (encoding Mothers against decapentaplegic homolog 3, causing aneurysms-osteoarthritis syndrome). Two groups (Boileau et al, Lindsay et al) sought to identify additional genes responsible for familial thoracic aortic aneurysms. They also sought to explain an apparent paradox: mutations in the aforementioned genes that would be predicted to result in reduced activity of the TGF-β pathwayappear to cause vasculopathy via increased TGF-β signaling.. ...
TY - JOUR. T1 - Patterns of aortic remodelling after total arch replacement with frozen elephant trunk for acute aortic dissection. AU - Iida, Yasunori. AU - Fujii, Susumu. AU - Shimizu, Hideyuki. AU - Sawa, Shigeharu. PY - 2019/12/1. Y1 - 2019/12/1. N2 - OBJECTIVES: We investigated the outcomes of total arch replacement with frozen elephant trunk (FET) for Stanford type A acute aortic dissection and the patterns of postoperative aortic remodelling from computed tomographic (CT) findings. METHODS: From April 2015 to November 2018, we performed total arch replacement with FET for Stanford type A aortic dissection in 30 patients. Postoperative contrast-enhanced CT showed the position of the FET distal end, the number and the site of communications between the lumina and the presence or absence of aortic remodelling. RESULTS: Primary entry tear was found in the ascending aorta (n = 6), proximal arch (n = 6), aortic arch (n = 11) and distal arch (n = 7). The mean diameter and length of FET were 26 ...
The suitable treatment strategy for acute descending aortic dissection has long been a matter of debate and continues to be a challenge [1]. High mortality rates in surgical treatment (25-50%) of complicated acute type B dissections, directed surgeons to search for other treatment modalities. Implementation of endovascular techniques has provided new therapeutic options [5]. Initial series and subsequent multicenter trials demonstrated technical feasibility and a low rate of complications even in high-risk patients with acute type B dissection.. However, treatment of acute aortic dissections by endovascular grafting itself carries some risks. Leakage can occur in approximately 25% of patients. Rarely, the stent graft may not plug the aortic wall adequate and may dislocate. In 8% of patients embolic material may originate from an atherosclerotic basis and corrupt the blood flow of the spinal cord, leading to paraplegia. There is furthermore the risk for abdominal malperfusion. In this situation ...
OBJECTIVE: Endovascular stent-grafts had been used since 1999 in China for the treatment of type B aortic dissection, and there is a plethora of cohort studies in the contemporary literature. The aim of this paper is to analyze the published results of endovascular treatment for type B aortic dissection in China. METHOD: A systematic literature review was undertaken of all published literature from January 1999 to December 2014 on endovascular treatment of type B aortic dissection in China using PubMed, MEDLINE and Chinese National Knowledge Infrastructure (CNKI) databases. RESULTS: There were 70 papers retrieved (4 English, 66 Chinese) with a total of 4208 patients. 3396 patients (80.7%) were males, mean age ranged from 43 to 65 years. Procedural success was reported in 99.4 ± 1.7% of patients, 5 patients required emergency conversion to open operation. Overall complications were reported in 14.6 ± 11.1% of the patients. Major complications were reported in 1.7 ± 2.9% with the most ...
A 46-year-old man was given a diagnosis of hypertension about 20 years previously. At age 41, aortitis syndrome was diagnosed, with descending thoracic aortic aneurysm and the coarctation of abdominal aorta by CT scan. He then underwent surgery to replace the descending thoracic aortic aneurysm and right axillo-bifemoral bypass. Recently, a thoraco-abdominal aortic aneurysm was pointed out at the distal site of the graft and, he was referred to our institute. We occluded the distal end of the aneurysm using an endoluminal occlusion stent graft. Today, in most cases of aortopathy associated with aortitis syndrome, surgical replacement of the aneurysms and extra-anatomical bypass is performed. An endovascular stent graft treatment combined with extra-anatomical bypass could be useful for various aortic disorders ...
However, along with the positive economic impact of gaming, there or are the inevitable negative motivational effects research of the problem and thoracic aortic aneurysm resulting ease in loss of productivity, suicide, trouble breathing, bankruptcy, and vulgar crime. Also, the fda has regularly asked the maker of controlled drug, meda pharmaceuticals inc., to add and a neatly boxed warning to its label and to develop a psychological medicine guide that
Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting
Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting
TY - JOUR. T1 - Operative and Midterm Outcomes of the Fenestrated Anaconda Stent-Graft in the Endovascular Treatment of Juxtarenal, Suprarenal, and Type IV Thoracoabdominal Aortic Aneurysms. AU - Kotelis, Drosos. AU - Schleimer, Karina. AU - Foldenauer, Christina. AU - Jalaie, Houman. AU - Grommes, Jochen. AU - Jacobs, Michael J.. AU - Kalder, Johannes. PY - 2016/12. Y1 - 2016/12. KW - abdominal aortic aneurysm. KW - endoleak. KW - endovascular aneurysm repair. KW - fenestrated stent-graft. KW - juxtarenal aneurysm. KW - mortality. KW - reintervention. KW - suprarenal aneurysm. KW - thoracoabdominal aortic aneurysm. U2 - 10.1177/1526602816667281. DO - 10.1177/1526602816667281. M3 - Article. VL - 23. SP - 930. EP - 935. JO - Journal of Endovascular Therapy. JF - Journal of Endovascular Therapy. SN - 1526-6028. IS - 6. ER - ...
October 23, 2018 -- Dublin -- Medtronic plc (NYSE:MDT) today announced it has received U.S. Food and Drug Administration (FDA) approval for the Valiant Navion thoracic stent graft system for the minimally invasive repair of all lesions of the descending thoracic aorta, including thoracic aortic aneurysms (TAA), blunt thoracic aortic injuries (BTAI), penetrating atherosclerotic ulcers (PAU), intramural hematomas (IMH), and aortic type B dissections (TBAD). Until now, patients with small iliac arteries were considered ineligible for thoracic endovascular aneurysm repair (TEVAR) or required adjunctive procedures to accommodate calcification and tortuosity concerns. Valiant Navion allows for the potential for more patients to receive a percutaneous procedure and overcome these anatomical concerns, enabling a less invasive approach to treatment compared to surgical cut-down (open) procedures. Our focus at Medtronic continues to be on advancing the treatment of complex aortic disease to improve ...
A number of autosomal dominantly inherited disorders, such as Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), are associated with predisposition to thoracic aortic aneurysms and dissections (TAADs). In the majority of cases, mutations in genes encoding components of the transforming growth factor-β (TGF-β) signaling pathway, such as FBN1, TGFBR1, TGFBR2 and SMAD3, underlie the disease. Recently, a familial syndromic form of TAAD with other clinical features that overlap the MFS-LDS spectrum has been described to be caused by heterozygous loss-of-function mutations in TGFB2, encoding the TGF-β2 ligand of TGF-β serine/threonine kinase receptors (TGFBRs). We analyzed the TGFB2 gene by sequencing in a cohort of 88 individuals with a Marfan-like phenotype and/or TAAD, who did not have mutations in known genes causing thoracic aortic disease. We identified the novel heterozygous c.1165dupA mutation in exon 7 of TGFB2 in three members of a family, a 51-year-old male, his brother and nephew with
Searchers launched a study of more than three million people-by far the largest ever-to uncover what. St ascending aortic aneurysms are diagnosed in. Eurysm was noted during workup for back pain, and CT was ordered after AAA was identified on. aneurysm anu rizm a sac formed by the localized dilatation of the wall of an artery, a vein, or the heart. ThodsWe examined differences between England and the United. Dications for surgical treatment of thoracic aortic aneurysms (TAAs) are based on size or growth rate and symptoms. CT demonstrates abdominal aortic aneurysm (AAA). Thoracic aortic aneurysm (TAA) can be due to one of several etiologies. Historical perspective. 9 out of 10 Cardiovascular Doctors Support Preventive Health Screenings For People At Risk. E natural history of TAA is one of progressive expansion, the rate of which depending upon! Abdominal aortic aneurysm; Synonyms: triple a: CT reconstruction image of an abdominal aortic aneurysm (white arrows) Classification and external ...
The medical therapies available to slow the growth of thoracic aortic aneurysms and reduce their risk of dissection or rupture are quite limited. In a randomized study of adults with Marfan syndrome, Shores et al31 found that treatment with propranolol (versus no β-blocker therapy) over 10 years resulted in a significantly slower rate of aortic dilatation, fewer aortic events, and lower mortality. Unfortunately, whether these benefits can truly be extrapolated to the non-Marfan population with thoracic aneurysms remains unknown. Nevertheless, it is mechanistically logical that medical therapy to reduce dP/dt and to control blood pressure would be beneficial for the treatment of all patients with thoracic aortic aneurysms. Moreover, given the safety of β-blockers, there is no downside to presumptive therapy, provided it is well tolerated. There is some early experimental evidence to suggest that oxidative stress may play a role in the pathogenesis of atherosclerotic thoracic aortic aneurysms ...
TY - JOUR. T1 - Rare cause of dyspnea. T2 - Yin-yang thoracic aortic aneurysm. AU - Ghera, Princy. AU - Hayes, Don. PY - 2014/4. Y1 - 2014/4. N2 - Aortic aneurysmal diseases, mostly found incidentally, have high mortality and morbidity. Complications mostly are associated with and accelerated in the presence of systemic hypertension, aortic valve disease, or aortic atherosclerosis. Presenting signs and symptoms can be nonspecific and need immediate and accurate recognition. We present a case of incidental finding of a large descending aortic aneurysm with yin-yang sign and discuss the importance of differentiating pseudoaneurysm versus intramural thrombus.. AB - Aortic aneurysmal diseases, mostly found incidentally, have high mortality and morbidity. Complications mostly are associated with and accelerated in the presence of systemic hypertension, aortic valve disease, or aortic atherosclerosis. Presenting signs and symptoms can be nonspecific and need immediate and accurate recognition. We ...
BACKGROUND: Aortic dissection is a separation of the aortic wall, caused by blood flowing through a tear in the inner layer of the aorta. Aortic dissection is an infrequent but life-threatening condition. The incidence of aortic dissection is 3 to 6 per 10,000 per year in the Western population, and can be up to 43 per 10,000 per year in the Eastern population. Over 20% of people with an aortic dissection do not reach a hospital alive. After admission, the mortality rates for people with an aortic dissection are between 10% and 20% for those who received endovascular treatment, and between 20% and 30% for those who had open surgery. Thoracic endovascular aortic repair (TEVAR) is the standard endovascular method to treat complicated type B aortic dissection (aortic dissections without involvement of the ascending aorta). Although TEVAR is less invasive than open surgery and has a better long-term aortic remodeling effect than conservative medical treatment, favourable aortic remodelling is ...
Abdominal Pain & Pupillary Abnormality & Thoracic Aortic Dissection Symptom Checker: Possible causes include Thoracic Aortic Aneurysm. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
We are pleased to have received CE Mark for the E-nya thoracic stent graft system, our next generation low profile solution for patients with aortic disease. The E-nya system was designed to give physicians more options and control while treating both simple and challenging anatomies, and will be one of the most versatile grafts on the market, said Pat Mackin, Chairman, President, and Chief Executive Officer of CryoLife. We are excited to bring this product to the European market, further enhancing our position as the leader in the growing EU aortic repair market.. Aortic aneurysms and dissections make up the largest portion of thoracic aortic disease which is an estimated $600 million global market. The vast majority of patients with thoracic aortic disease are treated with minimally invasive endovascular stent grafts. E-nya builds upon JOTECs experience in the thoracic endovascular aortic repair (TEVAR) market and increases the number of options to treat a broader range of patients. The ...
Treatment of endoleaks after thoracic endovascular repair remains challenging, particularly when the proximal landing zone is small and partly includes the origin of the neck vessels. We report a Type Ia endoleak, occurring after thoracic endovascula
FLAGSTAFF, Ariz. - October 20, 2017 - W. L. Gore & Associates, Inc. (Gore) today announced the first patient enrollment in its post-market European registry for the GORE®TAG® Conformable Thoracic Stent Graft with ACTIVE CONTROL System, following its recent European launch in July 2017. The thoracic endovascular aortic repair (TEVAR) device is the first to feature a new delivery system that provides the physician with controlled, staged deployment.. The first patient procedure in the registry was performed by Professor Giovanni Torsello and Doctor Martin Austermann at St. Franziskus Hospital, Münster, Germany. Professor Torsello, Chief of the Department of Vascular Surgery, stated, The GORE® ACTIVE CONTROL System was easy to use and provided a noticeably enhanced level of control in the placement and angulation of the GORE TAG Conformable Thoracic Stent Graft. Enrolling patients in Gores registry will help to determine the short- and long-term benefits of this new device, which we expect ...
Patient was in the right lateral decubitus position with the lower body slightly tilted to the left, and a left thoracoabdominal incision was performed. The cardiopulmonary bypass was established by a venous cannula placed in the right atrium through the left femoral vein and 2 arterial return cannulas inside both femoral artery and ascending aorta. If the proximal thoracic descending aorta was not involved by the aneurysm and was long enough for both clamping and anastomosis (usually Crawford extent III TAAA), proximal aortic anastomosis was performed under mild hypothermic cardiopulmonary bypass and beating heart. otherwise, it was performed using an open technique with profound hypothermic circulatory arrest.. During our modified multiple branched graft replacement of TAAA, the proximal aortic anastomosis was performed first. After a proximal aortic clamp was placed just distal to the left subclavian artery or profound hypothermic circulatory arrest was established, a distal aortic clamp was ...
This 80-year-old man presented to the ED with acute onset of chest pain.. His arterial phase CT shows the typical features of a Stanford type A dissection of the thoracic aorta. The left-hand transverse image shows the dissection flap (arrows) extending through the ascending (A) and descending (D) aorta. The flap is shown more clearly on the middle, sagittal image. On the right, the coronal CT image shows the dissection flap extending into the left common carotid artery, which is outlined by the dashed yellow line.. As you will remember, aortic dissection is stratified into one of two classifications based on the requirement for surgical intervention. Stanford type A dissections involve the ascending thoracic aorta, account for the majority of cases and have a high mortality rate if not treated with emergency surgery1. Stanford type B dissections involve the descending thoracic aorta, distal to the origin of the left subclavian artery. These are typically treated medically with management of ...
Acher CW, Wynn M. Thoracic and thoracoabdominal aneurysms: open surgical treatment. In: Sidawy AN, Perler BA, eds. Rutherfords Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 77.. Braverman AC. Diseases of the aorta. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwalds Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 57.. Lederle FA. Diseases of the aorta. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 78.. Singh MJ, Makaroun MS. Thoracic and thoracoabdominal aneurysms: endovascular treatment. In: Sidawy AN, Perler BA, eds. Rutherfords Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 78.. BACK TO TOP. Review Date: 6/10/2018 Reviewed By: Deepak Sudheendra, MD, FSIR, RPVI, Assistant Professor of Interventional Radiology & Surgery at the University of Pennsylvania Perelman ...
This study evidences for the first time the arterial fragility of Col3a1 insufficient mice and their susceptibility to develop thoracic aortic dissections and ruptures in response to AngII. As observed in vEDS patients, in this AngII infusion model, Col3a1+/− mice died prematurely and significantly more when compared with Col3a1+/+ mice. The haploinsufficiency in type III collagen confers an important fragility to the thoracic aortic wall in response to rapid and important rises in SBP induced by a high-dose of AngII. In this model, BP seems to be a major trigger of this fragility since (1) early deceased Col3a1+/− mice had also the highest rises in SBP, and (2) lowering by half the dose of AngII and its associated increases in SBP (26 to 13 mm Hg) rescued the first-week premature deaths observed in Col3a1+/− mice. This is consistent with the contribution of collagen to the mechanical properties of the arterial wall and the preponderance of type III collagen in the media. However, NE ...
At the session entitled Pushing the boundaries of EVAR and TEVAR, CX delegates received information on case reports from Argentina, Brazil and Puerto Rico. Frank Criado, Baltimore, USA, chaired the session with Frans Moll, Utretcht, The Netherlands, and Tulio Navarro, Belo Horizonte, Brazil, as moderators. Mariano Ferreira, Buenos Aires, Argentina, presented a case of a 74-year-old man with a 7cm thoraco-abdominal aneurysm with distal dilatation of the aortic arch that was treated in a three-staged thoracic endovascular aortic repair (TEVAR) procedure. Ferreira said: Due to elevated spinal cord ischaemic risk, a three-staged TEVAR procedure was planned with prophylactic left subclavian artery revascularisation.. He explained that the patient underwent TEVAR under general anaesthetic with adjunctive spinal fluid drainage. Through a direct right femoral access, three Gore Tag thoracic endoprostheses (40 x 140mm, 37 x 200mm and 34 x 200mm) were implanted in an overlapping proximal-to-distal ...
Present and future cardiothoracic intensivists will enjoy this talk by Brian Plunkett on thoracic aortic dissection given at Bedside Critical Care Conference 4.. ...
My clinical interests in adult cardiac surgery include surgery for thoracic aortic aneurysm, open and endovascular thoracic and thoracoabdominal aortic repair, heart valve surgery, high-risk reoperation surgery, minimally invasive cardiac surgery and percutaneous valve treatment. I believe in a patient centered approach by combining the traditional open cardiac and vascular surgery with the cutting edge catheter-based interventions and endovascular surgery to provide the best outcomes for my patients. Some of the areas of my clinical interest are coronary artery bypass grafting, aortic and mitral valve repair, arrhythmias surgery, hybrid aortic repair and heart transplantation. I treat the patients with bicuspid aortic valve and other connective-tissue disorders such as Marfan, Loeys-Dietz syndrome and Ehlers-Dalos syndromes ...
TY - JOUR. T1 - Techniques for preserving vertebral artery perfusion during thoracic aortic stent grafting requiring aortic arch landing. AU - Woo, Edward Y.. AU - Bavaria, Joseph E.. AU - Pochettino, Alberto. AU - Gleason, Thomas G.. AU - Woo, Y. Joseph. AU - Velazquez, Omaida C. AU - Carpenter, Jeffrey P.. AU - Cheung, Albert T.. AU - Fairman, Ronald M.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Thoracic endografting offers many advantages over open repair. However, delivery of the device can be difficult and may necessitate adjunctive procedures. We describe our techniques for preserving perfusion to the left subclavian artery despite endograft coverage to obtain a proximal seal zone. We reviewed our experience with the Talent thoracic stent graft (Medtronic, Santa Rosa, CA). From 1999 to 2003, 49 patients received this device (29 men, 20 women). Seventeen patients required adjunctive procedures to facilitate proximal graft placement. We performed left subclavian-to-left common carotid artery ...
Medtronic Inc have announced the start of THRIVE, the companys US post-market clinical study of its Talent thoracic stent graft for the endovascular repair of thoracic aortic aneurysms.. Addressing a condition of US Food and Drug Administration (FDA) approval, THRIVE will enroll a total of 451 patients at a minimum of 15 US sites. The studys primary endpoint is freedom from aneurysm-related mortality - defined as death from aneurysm rupture or from any procedure intended to treat the segment targeted by the Talent system - at five years.. ...
University Hospitals offers specialized care at our Aortic Center through coordinated evaluations and treatment for aneurysms including aortic abdominal aneurysms.
OBJECTIVE This study reports the early and midterm to long-term experience of chimney grafts (CGs) in urgent endovascular repair of complex lesions in the thoracic aorta. METHODS Twenty-nine high-risk patients (20 men) who were unfit for open repair were treated using CG technique for ruptured (n = 14) or symptomatic (n = 15) aortic lesions engaging the aortic arch itself (n = 9), the descending aorta (n = 10), or the thoracoabdominal aorta (n = 10). Twenty-two patients (76%) were treated urgently (≤24 hours) and seven were semiurgent (≤3 days). Of 41 chimneys used, 24 were placed in supra-aortic branches and 17 in visceral branches. Median follow-up (interquartile range) for the entire cohort was 2 years (0.6-3.8 years), 2.5 years (1-4 years) for 30-day survivors, and 3.5 years (1.9-6.4 years) for those who were still alive. RESULTS Four patients (14%) died ≤30 days of cerebral infarction (n = 1), visceral ischemia secondary to the initial rupture (n = 1), multiple organ failure (n = 1), or
Background: Vascular prosthetic graft infection is a severe complication after open aortic aneurysm repair. Reports of infected endografts are scarce. General treatment consensus with infected graft material is that it should be removed completely. The objective of this study was to describe the incidence of endograft infection after endovascular repair of abdominal (EVAR) selleck products and thoracic aortic aneurysm (TEVAR) and to report treatment options and their outcome.. Methods: A retrospective cohort study was performed of patients endovascularly operated for abdominal and thoracic aortic aneurysm in two large hospitals (one tertiary referral center and one large community hospital) between March 1996 and June 2009. Diagnosis of infected endograft was made based on clinical findings, blood tests and cultures, imaging studies (computed tomography, fludeoxyglucose positron emission tomography), and intraoperative findings at reoperation.. Results: Eleven patients with an infected ...
A 72-year-old woman underwent surgical stent graft implantation for a huge distal arch aneurysm i12 ~11cm). Axillo-bifemoral bypass was added in order to restore visceral perfusion. Severe metabolic acidosis developed after the operation, and the patient died 6 hours after surgery. Autopsy showed thromboembolism of the superior mesenteric artery and aortic dissection in the descending thoracic aorta because of stent graft insertion into a false lumen. To reduce complications like this case, we should consider the peculiar anatomic features and thoroughly evaluate atheromatous changes in the aortic wall with improvement of the shape of the sheath and delivery system ...
There is a crescentic hyperdensity within the ascending thoracic aorta, likely representing a dissection flap containing previously administered IV contrast. The dissection flap measures approximately 3 mm along the posterior surface of the ascending aorta. There are calcifications along the aortic arch and descending aorta, probably representing atherosclerosis. ...
Medtronic plc (MDT) recently unveiled favorable three-year clinical outcome of its Valiant Captivia Thoracic Stent Graft System in patients with acute complicated Type B aortic dissection.
Endovascular repair of the thoracic aorta has been adopted as the first-line therapy for much pathology. Initial results from the early-generation endografts have highlighted the potential of this technique. Newer-generation endografts have now been introduced into clinical practice and careful assessment of their performance should be mandatory. This study describes the initial experience with the Valiant endograft and makes comparisons with similar series documenting previous-generation endografts. Data were retrospectively collected on 180 patients treated with the Valiant endograft at seven European centers between March 2005 and October 2006. The patient cohort consisted of 66 patients with thoracic aneurysms, 22 with thoracoabdominal aneurysms, 19 with an acute aortic syndrome, 52 with aneurysmal degeneration of a chronic dissection, and 21 patients with traumatic aortic transection. The overall 30-day mortality for the series was 7.2%, with a stroke rate of 3.8% and a paraplegia rate of 3.3%.
If you have a thoracic aortic aneurysm, surgery is generally recommended if your aneurysm is about 1.9 to 2.4 inches (about 5 to 6 centimeters) and larger. If you have Marfan syndrome, another connective tissue disease, a bicuspid aortic valve or a family history of aortic dissection, your doctor may recommend surgery for smaller aneurysms because you have a higher risk of having an aortic dissection. ...
Atıf İçin Kopyala İSBİR C. S. , BALTACIOĞLU F. , AK K. , DAL D., Atike T., ATALAN N., ...Daha Fazla 59th ESCVS International Congress in conjunction with the 6th Congress of Update in Cardiology and Cardiovascular Surgery, 15 - 18 Nisan 2010, cilt.10, ss.200 ...
Through 30 days of follow up in VALOR II, rates of site-reported endoleaks were low: 0.7% for type I, 3.4% for type II, and zero percent for both type III and IV. In addition, no patients treatment plans were converted from TEVAR to open surgery, and no patients experienced aneurysm rupture. The rate of all-cause mortality through 30 days was 3.1%.. These compelling interim data from VALOR II show great promise for the Valiant thoracic stent graft, said the studys principal investigator, Ronald Fairman, professor of surgery and chief of the division of vascular surgery and endovascular therapy at the Hospital of the University of Pennsylvania. We look forward to seeing whether these results persist at the primary endpoint of 12 months and supply the evidence needed so that clinicians in the United States can use the Valiant stent graft in their practice.. The studys primary safety and effectiveness endpoints are 12-month all-cause mortality and 12-month successful aneurysm treatment, ...
TY - CHAP. T1 - Pathophysiology of Abdominal Aortic Aneurysm - Genetic factors and Homocysteine metabolism. AU - Delaney, Chris. AU - Saleem, Hafees. AU - Wong, Yew Toh. AU - Spark, James. PY - 2011. Y1 - 2011. UR - http://www.intechopen.com/articles/show/title/pathophysiology-of-abdominal-aortic-aneurysm-genetic-factors-and-homocysteine-metabolism. M3 - Chapter. SN - 9789533074665. SP - 35. EP - 52. BT - Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysm. PB - InTech. ER - ...
Acute type A aortic dissections starting at the arch pose a challenge for cardiac surgeons. Open surgical repair requires deep hypothermic circulatory arrest for arch reconstruction and is associated with significant morbidity and mortality. Hybrid aortic repair techniques, with open arch debranching and thoracic endovascular aortic repair, have been employed in high-risk cases and challenging aortic pathology. Herein, we present a case of a 33-year-old African American male with a history of open thoracoabdominal aortic reconstruction and femoral-femoral artery bypass for a type B dissection who subsequently presented with new-onset chest pain and was found to have a retrograde type A dissection of a bovine arch with multiple dissection flaps and possible contrast extravasation on chest computed tomography ...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecules storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters. ...
TY - JOUR. T1 - Neuropsychologic outcome after deep hypothermic circulatory arrest in adults. AU - Reich, D. L.. AU - Uysal, S.. AU - Sliwinski, Martin John. AU - Ergin, M. A.. AU - Kahn, R. A.. AU - Konstadt, S. N.. AU - McCullough, J.. AU - Hibbard, M. R.. AU - Gordon, W. A.. AU - Griepp, R. B.. AU - Jonas, R. A.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Introduction: Pediatric patients undergoing prolonged periods of deep hypothermic circulatory arrest have been found to experience long-term deficits in cognitive function. However, there is limited information of this type in adult patients who are undergoing deep hypothermic circulatory arrest for thoracic aortic repairs. Methods: One hundred forty-nine patients undergoing elective cardiac or thoracic aortic operations were evaluated preoperatively; 106 patients were evaluated early in the postoperative period (EARLY), and 77 patients were evaluated late in the postoperative period (LATE) with a battery of neuropsychologic tests. Seventy-three ...
SLC6A4 Aortic aneurysm, familial thoracic 4; 132900; MYH11 Aortic aneurysm, familial thoracic 6; 611788; ACTA2 Aortic valve ... AGA Asphyxiating thoracic dystrophy 2; 611263; IFT80 Asphyxiating thoracic dystrophy 3; 613091; DYNC2H1 Asthma and nasal polyps ... aneurysms, and muscle cramps; 611773; COL4A1 Aniridia; 106210; PAX6 Anonychia congenita; 206800; RSPO4 Anterior segment ... MAPT Supravalvar aortic stenosis; 185500; ELN Surfactant metabolism dysfunction, pulmonary, 1; 265120; SFTPB Surfactant ...
He died of thoracic aortic aneurysm in 1993. Private Investment in Latin America: Renegotiating the Bargain (1975) Joseph J. ...
"Treatment of Thoracic Aortic Aneurysms." Presented St. John's Cardiovascular Institute Annual Symposium. Loughridge, B.P. 2000 ... American College of Cardiology Society of Thoracic Surgeons Southern Thoracic Surgical Association Fellow, International ... In 1971-72 Loughridge moved to Syracuse, New York where he served as a Senior Resident in Thoracic Surgery at the State ... Loughridge was the Chief of Thoracic and Cardiovascular Surgery at two of Tulsa's main hospitals, St. John Hospital and at St. ...
"Early Recognition of Acute Thoracic Aortic Dissection and Aneurysm". World Journal of Emergency Surgery. 8 (1): 47. doi:10.1186 ...
It may cause aortic regurgitation, thoracic aortic dissection, aneurysm and rupture. It is often associated with connective ... In tertiary syphilis the aortic root becomes so dilated that the aortic valve becomes incompetent and cor bovinum results. The ... Annuloaortic ectasia is a dilation of the proximal ascending aorta and aortic annulus. ... "Orphanet: Familial aortic dissection". www.orpha.net. Retrieved 29 May 2019. CS1 maint: discouraged parameter (link) https:// ...
Aortic disease: Aortic atherosclerosis, thoracic aortic aneurysm, and abdominal aortic aneurysm. An individual's risk for ... abdominal aortic aneurysm (AAA) diabetes mellitus Chronic Kidney Disease The Framingham/ATP III criteria were used to estimate ...
"Effect of extended cross-clamp time during thoracoabdominal aortic aneurysm repair". The Annals of Thoracic Surgery. The ... Certain surgeries for cerebral aneurysms or aortic arch defects require that blood circulation be stopped while repairs are ... European Journal of Cardio-Thoracic Surgery. Elsevier Science. 4 (7): 390-93. doi:10.1016/1010-7940(90)90048-5. PMID 2397132. " ... Society of Thoracic Surgeons. 66 (4): 1204-08. doi:10.1016/S0003-4975(98)00781-4. PMID 9800807. Archived from the original on ...
Forsch died suddenly from a thoracic aortic aneurysm on November 3, 2011. Less than a week before his death, he threw out the ...
... thoracic aortic aneurysms, an enlarged pulmonary artery and aberrant subclavian artery syndrome have been reported compressing ... "Ortner's Syndrome and Endoluminal Treatment of a Thoracic Aortic Aneurysm: A Case Report". Vascular and Endovascular Surgery. ... Aortic dissection More commonly affects the right recurrent laryngeal nerve as the most common type of aortic dissection is ... Al Kindi AH, Al Kindi FA, Al Abri QS, Al Kemyani NA (October 2016). "Ortner's syndrome: Cardiovocal syndrome caused by aortic ...
January 2006). "Ortner's Syndrome and Endoluminal Treatment of a Thoracic Aortic Aneurysm: A Case Report". Vascular and ... the definition has expanded to include aneurysms of the aortic arch, pulmonary hypertension due to mixed connective tissue ... October 2016). "Ortner's syndrome: Cardiovocal syndrome caused by aortic arch pseudoaneurysm". Journal of the Saudi Heart ...
"Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery ...
Journal of the American College of Cardiology Endovascular Versus Open Repair of Intact Descending Thoracic Aortic Aneurysms J ... "Endovascular vs Open Repair of Intact Descending Thoracic Aortic Aneurysms". PracticeUpdate. Retrieved 2021-04-09.CS1 maint: ... aortic arch, and complex abdominal aortic aneurysms. Oderich is also specialized and involved in the sponsored device trials ... The center developed research in endovascular repair of dissections and aortic aneurysms using such devices, with a significant ...
Einstein is the real Israel himself." On 26 November 2013, Einstein died age 74 after a ruptured thoracic aortic aneurysm. He ...
Common types of aneurysm include abdominal aortic aneurysm, thoracic aortic aneurysm and intracranial aneurysm. Most types of ... An aneurysm is a localized enlargement of arteries, characterized by a balloon-like bulge. It results from the abnormal ... D. (2014). "Aneurysm". AccessScience. doi:10.1036/1097-8542.034100. Cooke, John P; Marshall, Janice M (3 September 2016). " ... Mironov, A (20 July 2009). "026 Pathogenetic factors and management of distal dissecting brain aneurysms". Journal of ...
Certain mutations in the MYLK gene are associated with thoracic aortic aneurysms or thoracic aortic dissections. This disease ... A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It ... "Mutations in myosin light chain kinase cause familial aortic dissections". American Journal of Human Genetics. 87 (5): 701-7. ...
"Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery ...
Thoracic and Thoraco-abdominal aortic aneurysms, mitral valve surgery and the beating heart Coronary Artery Bypass surgery. "Dr ... Described a new operative technique for coarctation of aortic with type - B aortic dissection(Journal of Thoracic and ... Modified Circuit for Retrograde Central Perfusion- Asian Cardiovascular Thoracic Annals, 2003, March:11(1);85-86 (Aortic ... Annals Thoracic Surgery.1999;67(6):1631-1636) Published the data on adenosine preconditioning of the Myocardium in patients ...
... such as thoracic aortic aneurysm and ischaemic heart disease. The α-actin found in smooth muscles is also an interesting marker ... lead to thoracic aortic aneurysms and dissections". Nature Genetics. 39 (12): 1488-1493. doi:10.1038/ng.2007.6. PMID 17994018. ... It has been noted that the MYH11 mutation could be responsible for at least 14% of hereditary thoracic aortic aneurisms ... along with thoracic aortic disease". American Journal of Human Genetics. 84 (5): 617-627. doi:10.1016/j.ajhg.2009.04.007. PMC ...
"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms". The Journal of Thoracic ... A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote ...
"Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms". J Thorac Cardiovasc Surg ... A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote ...
Open aortic surgery Endovascular Aneurysm Repair (EVAR). Aortic dissection. Open aortic surgery Thoracic Endovascular Aneurysm ... August 1994). "Design of the abdominal aortic Aneurysm Detection and Management Study. ADAM VA Cooperative Study Group". J Vasc ... "The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a ... July 1996). "Intraoperative heparinisation, blood loss and myocardial infarction during aortic aneurysm surgery: a Joint ...
"Improved Prognosis of Thoracic Aortic Aneurysms: A Population-Based Study , Surgery , JAMA , JAMA Network". jamanetwork.com. ... lead to thoracic aortic aneurysms and dissections". Nature Genetics. 39 (12): 1488-1493. doi:10.1038/ng.2007.6. ISSN 1546-1718 ... "Distal Aortic Perfusion and Cerebrospinal Fluid Drainage for Thoracoabdominal and Descending Thoracic Aortic Repair". Annals of ... At the time of Safi's surgical training in the 70s and 80s, surgical treatment of thoracic aortic disease often led to an ...
July 2015). "14-3-3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis". Arthritis ...
Aortic aneurysm Aortic regurgitation Aortic dissection Aortic valve replacement Marfan syndrome Ross procedure Valve-sparing ... The Society of Thoracic Surgeons. 101 (5): 1684-1689. doi:10.1016/j.athoracsur.2015.10.090. Cardiac Surgery in the Adult ... Normal aortic valve with annular dilation and ascending aneurysm (frequently found in Marfan syndrome): Artificial heart valves ... Normal aortic root: The re-implantation of the coronary arteries is prone to complications, and aortic root replacement should ...
... and thoracic aortic aneurysm. A study of patients with SCSFLS demonstrated no mutations in this gene. Minor features of Marfan ... It may also run in families and be associated with aortic aneurysms and joint hypermobility. Up to two thirds of those affected ... Feichter I. (2019). "Intradural non-calcified thoracic disc herniation causing spontaneous intracranial hypotension: a case ... spinal cerebrospinal fluid leak as a cause of coma after craniotomy for clipping of an unruptured intracranial aneurysm". ...
The legislation became known as the Screening Abdominal Aortic Aneurysms Very Efficiently (SAAAVE) Act of 2004 (HR 4626). Lin ... Lin, P.H. (2008). "Endovascular repair of traumatic thoracic aortic injuries: a critical appraisal". Asian Cardiovasc Thorac ... His writing and speaking have focused on a range of subjects including endovascular treatment of aortic aneurysms, venous ... Lin, P.H. (2009). "Hypogastric artery preservation during endovascular aortic aneurysm repair: is it important?". Seminar of ...
For aneurysms of the thoracic aorta, thoracic endovascular aortic repair (TEVAR) has become a valid alternative to open repair ... The conventional approach for treatment of aortic valve stenosis is surgical replacement of the aortic valve. This procedure ... "Endovascular stenting versus open surgery for thoracic aortic disease: Systematic review and meta-analysis of perioperative ... However, TAVI (transcatheter aortic valve implantation) has emerged as a valid alternative for patients in whom conventional ...
... caused by a thoracic aortic aneurysm rupture, on 16 October 2017. The ARIA Awards has since paid tribute to Shedden, naming ...
GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections GeneReviews/NCBI/NIH/UW entry on Loeys-Dietz ... Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDS, LDAS). TGF beta receptor 1 has been ...
"A splenic injury due to ruptured abdominal aortic aneurysm." J Cardiovasc Surg (Torino) 2007;48:528 Gur O, Canbaz S, Karaca OG ... Enver Duran (born June 19, 1945 in Bursa) is a Turkish medic specialising in thoracic-cardiovascular surgery, a university ... Between the years 1985-1990 he worked as an associated professor in Gülhane Military Medical Academy Thoracic-Cardiovascular ... After he completed his General Surgery Specialization education in 1977-1980, he became a Specialist in Thoracic-Cardiovascular ...
An aneurysm is an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel. ... A thoracic aortic aneurysm occurs in the part of the bodys largest artery (the aorta) that passes through the chest. ... Most thoracic aortic aneurysms are detected on imaging tests performed for other reasons. These tests include chest x-ray, ... The most common cause of a thoracic aortic aneurysm is hardening of the arteries. This condition is more common in people with ...
Thoracic aneurysm may occur in three parts of the thoracic aorta: the ascending aorta, the descending aorta or the aortic arch ... Thoracic Aortic Aneurysm The aorta is the artery that carries oxygen-rich blood away from the heart and on to other arteries ... A thoracic aortic aneurysm occurs when a "balloon" forms in a weakened area of the aorta wall within the chest cavity. The ... A minor thoracic aortic aneurysm may have little effect on an individual, but can also be life-threatening and fatal if it ...
Familial thoracic aortic aneurysm and dissection (familial TAAD) involves problems with the aorta, which is the large blood ... medlineplus.gov/genetics/condition/familial-thoracic-aortic-aneurysm-and-dissection/ Familial thoracic aortic aneurysm and ... Genetic Testing Registry: Aortic aneurysm, familial thoracic 6 *Genetic Testing Registry: Congenital aneurysm of ascending ... Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. ...
By definition, an aneurysm is a localized or diffuse dilation of an artery with a diameter at least 50% greater than the normal ... encoded search term (Thoracic Aortic Aneurysm) and Thoracic Aortic Aneurysm What to Read Next on Medscape. Related Conditions ... Aneurysmal degeneration that occurs in the thoracic aorta is termed a thoracic aortic aneurysm (TAA). Aneurysms that coexist in ... Endovascular treatment of thoracic aortic aneurysms: results of the phase II multicenter trial of the GORE TAG thoracic ...
Thoracic aortic aneurysms (TAAs) can involve the aortic root, ascending aorta, arch, descending aorta, or a combination of ... although the average size of surgically corrected aneurysms is over 5cm. ... In the thoracic aorta, a diameter of 3 cm or greater is generally considered aneurysmal, ... encoded search term (Thoracic Aortic Aneurysm Pathology) and Thoracic Aortic Aneurysm Pathology What to Read Next on Medscape ...
A thoracic aortic aneurysm (TAA) is a bulging in the part of the aorta that passes through the chest. These are stories of ... And thats when the doctor saw it - a large aneurysm in Sandys aorta right above his heart.. More ...
A thoracic aortic aneurysm (TAA) is a bulging in the part of the aorta that passes through the chest. These are stories of ... And thats when the doctor saw it - a large aneurysm in Sandys aorta right above his heart.. More ... The Society of Thoracic Surgeons: Aortic Aneurysms * Medline Plus: Thoracic Aortic Aneurysms ...
Screening for thoracic aortic aneurysms. Conditions that cause a thoracic aortic aneurysm may run in families. Because of this ... Endovascular repair for thoracic aortic aneurysm. Endovascular repair for thoracic aortic aneurysm. In endovascular repair, ... Open chest surgery for thoracic aortic aneurysm. Open chest surgery for thoracic aortic aneurysm. Open chest surgery to repair ... Ascending aortic root aneurysm procedure. Ascending aortic root aneurysm procedure. An ascending aortic root aneurysm procedure ...
... repair is indicated for an asymptomatic thoracic aortic aneurysm with a root diameter greater than 5 cm. ... This patients echocardiogram demonstrates a thoracic aortic aneurysm with an aortic root diameter of 6.2 cm, which requires ... In patients with Marfan syndrome, repair is indicated for an asymptomatic thoracic aortic aneurysm with a root diameter greater ... Aortic root dilatation is typical of the disease, and the murmur heard on physical examination represents aortic regurgitation ...
The thoracic stent graft can be in one or two portions. ... A thoracic stent graft (20) has a tubular bio-compatible graft ... 28, 2002, entitled "Thoracic Aortic Aneurysm Stent Graft" discloses stent grafts that are useful in treating aortic aneurysms ... However, for an aneurysm that develops in the thoracic arch of the aorta, stent grafts are needed that are deployable to extend ... Reduced-strain extra-vascular ring for treating aortic aneurysm. US9526638. 2 Feb 2012. 27 Dic 2016. Endospan Ltd.. Implantable ...
Figure 2: Computed tomography scan of the chest showing a thoracic aortic aneurysm (4 × 6 cm, arrow) with a heterogeneous mass ... Hemoptysis caused by erosion of thoracic aortic aneurysm. Dongmei Sun and Sanjay Mehta ...
Read about the types of thoracic aortic aneurysms and their common symptoms. UPMC offers various treatments and repair ... Thoracic Aortic Aneurysm​. Descending Thoracic and Thoracoabdominal Aortic Aneurysms. A descending thoracic aortic aneurysm is ... Thoracic aortic aneurysm symptoms. Descending thoracic aortic aneurysms (TAAs) and thoracoabdominal aortic aneurysms (TAAAs) ... Learn More About Thoracic and Thoracoabdominal Aortic Aneurysms. From the Society for Vascular Surgery. *Thoracic Aortic ...
Thoracic aneurysms are less common than abdominal ones. In some individuals with a thoracic aortic aneurysm, an underlying ... A thoracic aortic aneurysm (TAA) is a ballooning of a portion of the aorta, the largest artery in the human body. Aneurysms are ... Thoracic aortic aneurysms (TAAs) are considered high risk for rupture if they are located below the aortic arch and greater ... Aneurysms of the descending thoracic aorta are the most common of the thoracic aneurysms, followed by the ascending segment and ...
New to this forum. Diagnosed from two different type tests an echo and then three months(july 2012) later a CT Scan; measurements went from 4.9 to 4.7...
Thoracic Aortic Aneurysms. Thoracic aneurysms may involve one or more aortic segments (aortic root, ascending aorta, arch, or ... Abdominal Aortic Aneurysms. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms. Age is an important ... Bicuspid Aortic Valve Many cases of ascending thoracic aortic aneurysms are associated with an underlying bicuspid aortic valve ... Familial Thoracic Aortic Aneurysm Syndrome Cystic medial degeneration is also seen in patients with ascending thoracic aortic ...
Aneurysm. Aortic Aneurysm. Aortic Aneurysm, Thoracic. Vascular Diseases. Cardiovascular Diseases. Aortic Diseases. ... Genetics Home Reference related topics: Familial thoracic aortic aneurysm and dissection MedlinePlus related topics: Aneurysms ... Clinical Study of Thoracic Aortic Aneurysm Exclusion (Valiant). The safety and scientific validity of this study is the ... Thoracic aortic aneurysms. In: Haimovicis Vascular Surgery, 4th ed, H Haimovici, E Ascer, LH Hollier, DE Strandness, and JB ...
What is an abdominal aortic aneurysm? (0:04) 2. What is a thoracic aneurysm? (0:22) 3. What causes aneurysms? (0:46) 4. How is ... What are the symptoms of a thoracic aneurysm? (1:26) 6. What are the symptoms of an abdominal aneurysm? (1:50) 7. Who is at ... Surgery Christopher Abularrage and Associate Professor of Surgery James Black discuss abdominal and thoracic aortic aneurysms. ... When are aneurysms treated? (4:09) 11. What are the tests to determine treatment for aneurysms? (4:35) ...
Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of genetically triggered defects in aortic ... National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) Investigators, ... expression was induced in aortic SMCs after transverse aortic constriction, and Foxe3. deficiency increased SMC apoptosis and ... thus defining an additional molecular pathway that leads to familial thoracic aortic disease. ...
However, if you do have symptoms, they will depend on the location and size of the aneurysm. ... Very few people with thoracic aortic aneurysm notice symptoms. ... known as a thoracic aortic aneurysm (TAA).. Thoracic aortic ... Thoracic Aortic Aneurysm. ​The aorta is the largest artery in the body. It runs through the chest cavity (where it is called ... Very few people with thoracic aortic aneurysm notice symptoms. However, if you do have symptoms, they will depend on the ...
"Patients with descending thoracic aneurysm and thoraco-abdominal aneurysm are probably the highest-risk group of patients with ... Specialists Launch "Most Comprehensive" Web Site On Thoracic Aortic Aneurysm, Dissection. 16.09.2003 ... including aortic aneurysm and aortic dissection, the catastrophic bleeding that reportedly took the life of actor John Ritter ... Thoracic surgeons such as Dr. Raissi specialize in repair and replacement techniques for the ascending aorta, aortic arch and ...
How is a thoracic aortic aneurysm diagnosed?. Early diagnosis of a thoracic aneurysm is critical to managing the condition. The ... larger the thoracic aortic aneurysm, or the faster it grows, the more likely it is to rupture. The risk of rupture increases ... Diagnosing a thoracic aneurysm is difficult because often there are no symptoms, and often the condition goes undiagnosed until ... Heart, Vascular & Thoracic Institute (Miller Family). The latest information about heart & vascular disorders, treatments, ...
Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression.. Li Y1, Maegdefessel ... Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression ... Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression ... MicroRNA (miRNA); aortic aneurysm; gene expression regulation; long non-coding RNA (lncRNA); non-coding RNA (ncRNA); vascular ...
I was diagnosed with a thoracic aortic aneurysm in Nov. 2009 at 4.3 cm. It goes from the aortic root and tapers off at the ... HealingWell.com Forum , Diseases & Conditions , Heart & Cardiovascular Disease , Diagnosed with a thoracic aortic aneurysm ... that spikes in blood pressure seemed to precipitate dissection then rupture of aneurysm in a large amount. of a group of 170 or ... aortic arch, apparently extending through the entire ascending aorta. Six months later it was said to be 4.1 cm. Measurements ...
... thoracic aortic aneurysm) in the main artery (aorta) that carries blood from the heart to the lower half of the body. ... Endovascular repair is surgery to fix a weakened part (thoracic aortic aneurysm) in the main artery (aorta) that carries blood ... The size and location of the abdominal aortic aneurysm, and a persons general health, will determine if the endovascular ... When the aneurysm is small, careful monitoring may be the only treatment is necessary. ...
... β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms," Circulation, vol. 9, 11 ... J. A. Elefteriades, "Thoracic aortic aneurysm: reading the enemys playbook," The Yale Journal of Biology and Medicine, vol. 81 ... L. Scola, F. M. Di Maggio, and L. Vaccarino, "Role of TGF-β pathway polymorphisms in sporadic thoracic aortic aneurysm: rs900 ... D. Wu, P. Albini, G. Xu et al., "Nlrp3 inflammasome is upregulated in thoracic aortic aneurysms and dissections," Journal of ...
Ascending thoracic aortic aneurysm (ATAA) has been associated with diminished biomechanical strength and disruption in the ... Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters.. Pasta S1, Phillippi JA2, Tsamis ... Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Thoracic Aortic Disease, ... Center for Thoracic Aortic Disease, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA; Center for Vascular ...
... recovery and follow-up care for Thoracic aortic aneurysm. ... Learn about Thoracic aortic aneurysm, find a doctor, ... A thoracic aortic aneurysm occurs in the part of the bodys largest artery (the aorta) that passes through the chest. ... Most thoracic aortic aneurysms are detected on imaging tests performed for other reasons. These tests include chest x-ray, ... The most common cause of a thoracic aortic aneurysm is hardening of the arteries. This condition is more common in people with ...
From June 1974 to December 2001 we performed operative treatment on 33 patients with descending thoracic or thoracoabdominal ... aortic aneurysm in association with Takayasu disease. There were 25 men and 8 women with a mean age of 40.2A years (range 16- ... Aorta, Thoracic / surgery. Aortic Aneurysm, Abdominal / surgery*. Aortic Aneurysm, Thoracic / surgery*. Blood Vessel Prosthesis ... 3656588 - Tuberculous aneurysm of the descending thoracic aorta.. 6396838 - Surgery of thoracoabdominal aortic aneurysms.. ...
This has been referred to as Dysphagia Aortica, and is a late presentation of large thoracic aneurysms, or a symptom of ... Extrinsic oesophageal compression leading to dysphagia is a recognised but uncommon sole presentation of thoracic aortic ... Thoracic aortic aneurysm presenting with dysphagia: a fatal delay in diagnosis Thorac Surg Sci. 2007 Feb 26;4:Doc01. ... When dealing with patients who present with dysphagia, if no other cause is discovered, a thoracic aortic aneurysm should form ...
... ranging from treatment of heart disease to minimally invasive aortic aneurysm repair. ... Aortic aneurysm surgery - Cleveland Clinics Heart and Vascular Institute has a vast and renowned team of physicians who offer ... Aortic Aneurysms.(2006). (Accessed May 18, 2006). *Vascular Web, Society for Vascular Surgery. Thoracic Aneurysm. (2006). ( ... The standard surgical treatment for thoracic aortic aneurysms is open-chest aneurysm repair, but Cleveland Clinic surgeons are ...
  • A thoracic aortic aneurysm is the "ballooning" of the upper aspect of the aorta, above the diaphragm. (wikipedia.org)
  • citation needed] There are a number of causes, Aneurysms in patients younger than 40 usually involve the ascending aorta due to a weakening of the aortic wall associated with connective tissue disorders like the Marfan and Ehler-Danlos syndromes or congenital bicuspid aortic valve. (wikipedia.org)
  • Younger patients may develop aortic aneurysms of the thoracoabdominal aorta after an aortic dissection. (wikipedia.org)
  • People diagnosed with Marfan syndrome should immediately have an echocardiogram to measure the aorta, and followed up 6 months later to check for aortic enlargement. (wikipedia.org)
  • A thoracic aorta greater than 4.5 cm is generally defined as aneurysmal, while a size greater than 6 cm is the distinction for treatment, which can be either endovascular or surgical, with the former reserved for pathology at the descending aorta. (wikipedia.org)
  • Aneurysms in the ascending aorta may require surgery at a smaller size than aneurysms in the descending aorta. (wikipedia.org)
  • In the aorta, this can result in the formation of a fusiform aneurysm. (wikipedia.org)
  • A thoracic aortic aneurysm occurs in the part of the body's largest artery (the aorta) that passes through the chest. (medlineplus.gov)
  • Blood leaks along the wall of the aorta (aortic dissection). (medlineplus.gov)
  • A chest CT scan shows the size of the aorta and the exact location of the aneurysm. (medlineplus.gov)
  • An aortogram (a special set of x-ray images made when dye is injected into the aorta) can identify the aneurysm and any branches of the aorta that may be involved. (medlineplus.gov)
  • Surgery to replace the aorta is recommended if an aneurysm is larger than 5 to 6 centimeters. (medlineplus.gov)
  • Major surgery is done to replace the aorta with a fabric graft if the aneurysm is larger than 6 centimeters. (medlineplus.gov)
  • A thoracic aortic aneurysm occurs when a "balloon" forms in a weakened area of the aorta wall within the chest cavity. (emoryhealthcare.org)
  • Thoracic aneurysm may occur in three parts of the thoracic aorta: the ascending aorta, the descending aorta or the aortic arch. (emoryhealthcare.org)
  • This part of the aorta is called the thoracic aorta because it is located in the chest (thorax). (medlineplus.gov)
  • In familial TAAD, the aorta can become weakened and stretched (aortic dilatation), which can lead to a bulge in the blood vessel wall (an aneurysm). (medlineplus.gov)
  • These aortic abnormalities are potentially life-threatening because they can decrease blood flow to other parts of the body such as the brain or other vital organs, or cause the aorta to break open (rupture). (medlineplus.gov)
  • Occasionally, people with familial TAAD develop aneurysms in the brain or in the section of the aorta located in the abdomen ( abdominal aorta ). (medlineplus.gov)
  • Aneurysmal degeneration that occurs in the thoracic aorta is termed a thoracic aortic aneurysm (TAA). (medscape.com)
  • Aneurysms that coexist in both segments of the aorta (thoracic and abdominal) are termed thoracoabdominal aneurysms (TAAAs). (medscape.com)
  • Aneurysms that involve the ascending aorta may extend as far proximally as the aortic annulus and as far distally as the innominate artery, whereas descending thoracic aneurysms begin beyond the left subclavian artery. (medscape.com)
  • Dissection is another condition that may affect the thoracic aorta. (medscape.com)
  • Dissection should not be termed dissecting aneurysm, because it can occur with or without aneurysmal enlargement of the aorta. (medscape.com)
  • [ 4 ] They successfully replaced the ascending aorta with an aortic allograft. (medscape.com)
  • In the thoracic aorta, a diameter of 3 cm or greater is generally considered aneurysmal, although the average size of surgically corrected aneurysms is over 5cm. (medscape.com)
  • Thoracic aortic aneurysms (TAAs) can involve the aortic root, ascending aorta, arch, descending aorta, or a combination of these locations. (medscape.com)
  • A proximal aneurysm of the aorta is seen (5 x 4 cm), with focal rupture and hemopericardium (not shown). (medscape.com)
  • Aneurysmal dilatation of the thoracic aorta can occur by various mechanisms. (medscape.com)
  • And that's when the doctor saw it - a large aneurysm in Sandy's aorta right above his heart. (medtronic.com)
  • This painless test can provide your doctor with clear images of your aorta, and it can detect the size and shape of an aneurysm. (mayoclinic.org)
  • If your doctor finds you have an enlarged aorta or an aneurysm, you'll likely need another imaging test within six months to make sure your aorta hasn't grown larger. (mayoclinic.org)
  • A descending thoracic aortic aneurysm is a bulging, weakened area in the wall of the aorta, in the part that runs downward through the chest (thorax). (upmc.com)
  • A thoracoabdominal aortic aneurysm is one that is located in the area where the aorta crosses between the chest and abdomen. (upmc.com)
  • The risk of rupture increases when the aneurysm is larger than about twice the normal diameter of a healthy aorta blood vessel. (upmc.com)
  • Open aneurysm repair - A surgeon makes an incision in your chest and replaces the weakened portion of the aorta with a fabric tube, called a graft. (upmc.com)
  • The surgeon may either repair or bypass vessels, if the aneurysm involves important branches of the aorta. (upmc.com)
  • A thoracic aortic aneurysm (TAA) is a ballooning of a portion of the aorta, the largest artery in the human body. (ucdavis.edu)
  • Aneurysms in the thoracic or chest portion of the aorta are relatively rare. (ucdavis.edu)
  • The aorta, which carries freshly oxygenated blood to all parts of the body, is divided into four parts: 1) the ascending aorta which rises up from the left ventricle of the heart 2) the aortic arch, which curves like the hook connecting to the 3) descending thoracic aorta which extends downward through the chest cavity to the 4) abdominal aorta. (ucdavis.edu)
  • Aneurysms of the descending thoracic aorta are the most common of the thoracic aneurysms, followed by the ascending segment and then the arch. (ucdavis.edu)
  • If the aneurysm is located in the arch or the ascending portion of the thoracic aorta, it is considered at risk for rupture at a diameter of 5.5 centimeter or larger. (ucdavis.edu)
  • If located in the ascending thoracic aorta or the aortic arch, the surgeon must make an incision in the sternum. (ucdavis.edu)
  • If located in the descending thoracic aorta, the incision is made in the back below the shoulder blade and extends around the side of the rib cage to just under the breast. (ucdavis.edu)
  • Aneurysms of the aorta are at times evaluated and treated by physicians from a number of specialties. (ahajournals.org)
  • Indeed, whereas cardiac surgeons operate on the ascending aorta and arch and vascular surgeons manage abdominal aortic aneurysms, at present the responsibility often falls to cardiologists to oversee the medical care of patients with aortic disease of all types. (ahajournals.org)
  • Thoracic aneurysms may involve one or more aortic segments (aortic root, ascending aorta, arch, or descending aorta) and are classified accordingly ( Figure 1 ). (ahajournals.org)
  • Aneurysms of the ascending thoracic aorta most often result from cystic medial degeneration, which appears histologically as smooth muscle cell dropout and elastic fiber degeneration. (ahajournals.org)
  • It was once thought that such aneurysms were due to "poststenotic dilatation" of the ascending aorta, but the data suggest otherwise. (ahajournals.org)
  • Subject is diagnosed with one of the following conditions of the descending thoracic aorta. (clinicaltrials.gov)
  • The ascending thoracic aorta is designed to withstand biomechanical forces from pulsatile blood. (jci.org)
  • Our data demonstrate that FOXE3 mutations lead to a reduced number of aortic SMCs during development and increased SMC apoptosis in the ascending aorta in response to increased biomechanical forces, thus defining an additional molecular pathway that leads to familial thoracic aortic disease. (jci.org)
  • B ) Ascending aortic pathology in individual III:12 from family TAA337 and control aorta. (jci.org)
  • It runs through the chest cavity (where it is called the thoracic aorta), all the way down through the abdomen (where it is called the abdominal aorta). (hoag.org)
  • Dr. Raissi and his colleagues and predecessors at Cedars-Sinai have developed one of the most respected and innovative programs for the surgical treatment of thoracic aorta conditions. (innovations-report.com)
  • From the heart, the thoracic aorta extends upward (ascending aorta) before arching (aortic arch) and extending downward through the chest (descending aorta). (innovations-report.com)
  • Along the way, arteries branching from the thoracic aorta supply oxygen-rich blood to the heart muscle, head and neck, arms, and chest. (innovations-report.com)
  • Thoracic surgeons such as Dr. Raissi specialize in repair and replacement techniques for the ascending aorta, aortic arch and descending aorta - those within the chest cavity. (innovations-report.com)
  • A localized weakness or bulge in the aorta - an aneurysm - can become life-threatening if it ruptures, and victims often have few, if any, noticeable warning signs. (innovations-report.com)
  • Also, such inherited conditions as the connective tissue disorder Marfan syndrome can increase the risk of aortic dissection in which the interior layers of the aorta s wall rips. (innovations-report.com)
  • Aneurysms in varying locations of the aorta are defined as permanent dilations, predisposing to the fatal consequence of rupture. (nih.gov)
  • In the recent past, several non-coding RNAs (mainly microRNAs) have been discovered as being involved in aneurysm progression throughout varying locations of the aorta. (nih.gov)
  • It goes from the aortic root and tapers off at the aortic arch, apparently extending through the entire ascending aorta. (healingwell.com)
  • Endovascular repair is surgery to fix a weakened part (thoracic aortic aneurysm) in the main artery (aorta) that carries blood from the heart to the lower half of the body. (cooperhealth.org)
  • Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications," Interactive CardioVascular and Thoracic Surgery , vol. 14, no. 3, pp. 300-306, 2012. (hindawi.com)
  • A particular phenotype of ascending aorta aneurysms as precursor of type A aortic dissection," Interactive Cardiovascular and Thoracic Surgery , vol. 15, no. 5, pp. 840-846, 2012. (hindawi.com)
  • Abdominal aortic aneurysm involves a widening, stretching, or ballooning of the aorta. (mountsinai.org)
  • Aortic rupture (a tear in the aorta, which is the major artery coming from the heart) can be seen on a chest X-ray. (mountsinai.org)
  • In this case, it was caused by a traumatic perforation of the thoracic aorta. (mountsinai.org)
  • The aneurysm was confined to the thoracic aorta in 10 cases and involved both the thoracic and abdominal aorta in 23 cases. (biomedsearch.com)
  • Six patients had associated aneurysms of the proximal aorta, including five treated via the distal elephant trunk technique in first-stage procedures. (biomedsearch.com)
  • Aneurysm repair consisted of prosthetic replacement of the thoracoabdominal aorta in 31 cases, exclusion bypass in 1 case, and stent graft placement in 1 case. (biomedsearch.com)
  • A thoracic aortic aneurysm , an abnormal bulge in a weakened wall of the aorta in the chest area, can cause a variety of symptoms and often life-threatening complications. (clevelandclinic.org)
  • The standard surgical treatment for thoracic aortic aneurysms is open-chest aneurysm repair, but Cleveland Clinic surgeons are now able to treat many thoracic and thoracoabdominal (occurring in the lower part of the thoracic aorta and the upper part of the abdominal aorta) aneurysms with a minimally invasive procedure called an endovascular stent graft. (clevelandclinic.org)
  • The stent graft is then deployed in the diseased segment of the aorta and 'relines' the aorta like a sleeve to divert blood flow away from the aneurysm. (clevelandclinic.org)
  • Physical characteristics of the aorta and the aortic aneurysm itself are very important in determining if endovascular aorta repair is the best treatment. (clevelandclinic.org)
  • An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. (curehunter.com)
  • This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm. (curehunter.com)
  • A thoracic aortic aneurysm (TAA) is a balloon-type bulge (aneurysm) in a weak or damaged wall of your aorta (your body's largest artery). (aurorahealthcare.org)
  • This type of aneurysm occurs in the portion of your aorta that's located in your chest. (aurorahealthcare.org)
  • Therefore, the thoracic aorta should be imaged at some point during the initial evaluation of an AAA. (sapbc.net)
  • Success or failure is critically dependent on the anatomy of the thoracic aorta. (sapbc.net)
  • Thoracic aortic aneurysms (TAAs) occur when a section of the aorta - the body s largest artery that carries blood out of the heart and into the organs of the body - weakens and bulges outward like a balloon in the section of the artery that runs down the chest. (innovations-report.com)
  • Surgical repair requires a surgeon to open the chest cavity, clamp off the aorta and sew a surgical graft in place to prevent an aneurysm from rupturing. (innovations-report.com)
  • Once the system is guided into position through the patient s arteries under fluoroscopy, a one- or two-piece, fabric-covered, self-expanding stent graft is placed inside the weakened section of the thoracic aorta to relieve pressure on the aneurysm, helping to reduce the risk of rupture. (innovations-report.com)
  • An aneurysm occurs when there is a bulging, weakened area in the wall of the aorta. (uhhospitals.org)
  • Aneurysms occur most often in the portion of the aorta that runs through the abdomen, known as an abdominal aortic aneurysm , or AAA. (uhhospitals.org)
  • A thoracic aortic aneurysm refers to the part of the aorta that runs through the chest. (uhhospitals.org)
  • Impact of beta-blockade premedication on image quality of ECG-gated thoracic aorta CT angiography. (duke.edu)
  • BACKGROUND: Thoracic aortic aneurysm is one of the most common aorta pathologies worldwide, which is commonly evaluated by computed tomography angiography (CTA). (duke.edu)
  • A thoracic aortic aneurysm, also called TAA, is a bulging, weakened area in the wall of the aorta (the largest artery in the body), resulting in an abnormal widening or ballooning greater than 50 percent of the vessel's normal diameter (width). (nyhq.org)
  • The aorta extends upward from the top of the left ventricle of the heart in the chest area (ascending thoracic aorta), then curves like a candy cane (aortic arch) downward through the chest area (descending thoracic aorta) into the abdomen (abdominal aorta). (nyhq.org)
  • The thoracic aorta can be divided into segments: ascending aorta, aortic arch, and descending aorta, as described above. (nyhq.org)
  • An aneurysm may be located in one of these areas and/or may be continuous throughout the aorta. (nyhq.org)
  • An aneurysm called a thoracoabdominal aneurysm involves a thoracic aortic aneurysm extending down to the abdominal aorta. (nyhq.org)
  • The more common fusiform-shaped aneurysm bulges or balloons out on all sides of the aorta. (nyhq.org)
  • With each heartbeat, the walls of the aorta expand and spring back, exerting continual pressure or stress on the already weakened aneurysm wall. (nyhq.org)
  • Identification of aneurysm-predisposing susceptibility genes may lead to gene-directed surgical therapy of the ascending aorta for patients with bicuspid aortic valves. (uniprot.org)
  • At right is a large aneurysm that has formed in the descending thoracic aorta. (sciencephoto.com)
  • Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. (spiedigitallibrary.org)
  • An aortic aneurysm is a cardiovascular disease that causes the dilation of the aorta diameter. (spiedigitallibrary.org)
  • Open surgery is more common and it involves exposure of the dilated portion of the aorta, with no presence of blood, and insertion of a synthetic graft that helps to prevent an aneurysm from bursting. (spiedigitallibrary.org)
  • A thoracic aortic aneurysm repair is a surgery to fix a problem in the aorta. (lahey.org)
  • The thoracic aorta is the part of the aorta in the chest. (lahey.org)
  • Widening of descending thoracic aorta shadow. (radiopaedia.org)
  • Descending thoracic aorta shadow is widened. (radiopaedia.org)
  • A thoracic aortic aneurysm is a weakening or bulge of the wall of the aorta in the upper part that passes through the chest cavity. (dignityhealth.org)
  • If a thoracic aortic aneurysm bursts, your doctor will perform emergency aortic aneurysm repair surgery to replace the damaged portion of the aorta with a synthetic vessel. (dignityhealth.org)
  • In particular, in thoracic aorta section, object of our dissertation, diverse age-related changes occur and are responsible for onset of thoracic aorta dysfunction and pathological entities, including medial degeneration (MD) and remodelling. (thefreelibrary.com)
  • The normal width of the thoracic aorta is 2.8-4.5cm. (carolineghetes.com)
  • Class I. Aneurysm of the thoracic aorta, renal artery, or splenic artery is often detected incidentally but can present acutely with dissection or rupture, with a high risk of death or morbidities. (carolineghetes.com)
  • Turner syndrome is associated with short stature and greater risk of rupture for the same aorta size, so indexed measurements are preferred.26 It is also associated with bicuspid aortic valve and aortic coarctation, so concurrent cardiovascular surgery is often required. (carolineghetes.com)
  • Optimal treatment strategies for lesions of the thoracic aorta are still controversial. (eurekaselect.com)
  • Endovascular treatment of vascular disease involving the descending thoracic aorta can be performed safely. (eurekaselect.com)
  • The goal of this article is to review endovascular repair of the thoracic aorta in the current literature outlining some recent patents. (eurekaselect.com)
  • The thoracic aorta is constantly exposed to mechanical forces generated by heart contraction and blood flow. (brightsurf.com)
  • Thoracic aortic aneurysms (TAAs) are life-threatening diseases defined as a permanent abnormal dilatation of the thoracic aorta. (brightsurf.com)
  • From the lumen models, centerlines of the thoracic aorta, brachiocephalic artery, left common carotid artery, and left subclavian artery and their branching ostia positions were quantified. (sigmaaldrich.com)
  • A thoracic aortic aneurysm (TAA) is the widening or ballooning of the ascending aorta, aortic arch and/or descending aorta which weakens the artery. (uchicagomedicine.org)
  • An aneurysm that extends throughout the aorta from the chest to the abdomen. (uchicagomedicine.org)
  • In the setting of severe infection, the aortic root is reconstructed using cadaveric human (homograft) aorta. (uchicagomedicine.org)
  • Thoracic aortic aneurysms (TAAs) are abnormal dilatations of the aorta above the diaphragm. (merckmanuals.com)
  • Aneurysms of the ascending aorta sometimes affect the aortic root, causing aortic valve regurgitation or occlusion of the coronary arterial ostia, causing angina, myocardial infarction, or syncope. (merckmanuals.com)
  • Congenital connective tissue disorders (eg, Marfan syndrome , Ehlers-Danlos syndrome , Loeys-Dietz syndrome) cause cystic medial necrosis, a degenerative change that leads to TAAs complicated by aortic dissection and by widening of the proximal aorta and aortic valve (annuloaortic ectasia), which causes aortic regurgitation . (merckmanuals.com)
  • A nylon line (0.486mm in diameter) was inserted since the side-branch of femoral artery until the end reached the mid of thoracic aorta. (ahajournals.org)
  • In wild-type mice, survival rate at 4 weeks after the procedure was 67% (28/42) and thoracic aorta aneurysm developed in 85% (26/28). (ahajournals.org)
  • These results suggest that TNF-alpha might play the role not only in accelerating vascular remodeling, but also in salvage from the aortic rupture in severe injured aorta by accumulating supporting cells. (ahajournals.org)
  • Compression of the bronchus, oesophagus, and vertebra is well described and there have been isolated case reports of dissecting aneurysm of the thoracic aorta presenting as right atrial obstruction. (bmj.com)
  • The chest radiograph showed a grossly tortuous and unfolded thoracic aorta, which was proved by subsequent computed tomography (CT) to be aneurysmal from its origin to just above the kidneys. (bmj.com)
  • CT of his chest showed that the aneurysmal descending thoracic aorta was displacing his heart anteriorly and compressing the left atrium (fig 2). (bmj.com)
  • Introduction Chronic thoracic aortic aneurysm (CTAA) affecting the arch or descending aorta is an indolent but life-threatening condition with a rising prevalence as the UK population ages. (bmj.com)
  • The treatment of complex diseases of the aorta that involve the aortic arch using a hybrid procedure aims at reconstructing several segments within a single intervention. (scielo.br)
  • We present the case of a 53-year-old woman with a spontaneous AAD that extended retrograde into the thoracic aorta with a concomitant supraceliac intimal tear and an infrarenal AAA repaired electively with a hybrid approach using a supraceliac stent graft and an open infrarenal aortobiiliac graft. (biomedsearch.com)
  • In this paper, we investigate the progression of Ascending Thoracic Aortic Aneurysms (ATAA) using a computational model of Growth and Remodeling (G&R) taking into account the composite (elastin, four collagen fiber families and Smooth Muscle Cells-SMCs) and multi-layered (media and adventitia) nature of the aorta. (frontiersin.org)
  • Presented in the leading subspecialty, peer-reviewed journal in the field of vascular surgery, the study showed that patients with potentially life-threatening conditions of the thoracic aorta, including thoracic aortic aneurysms, can be treated effectively using a less invasive method associated with minimal blood loss, faster recovery, shorter hospital stays and decreased risk of death. (bio-medicine.org)
  • This study represents a significant milestone in managing complex conditions of the thoracic aorta," reported Julio A. Rodriquez-Lopez, M.D., lead author and medical director of Peripheral Vascular Services at the Arizona Heart Institute. (bio-medicine.org)
  • Clearly, the institution of endoluminal grafting represents a hallmark in the changing treatment paradigm for patients with potentially lethal and debilitating diseases of the thoracic aorta. (bio-medicine.org)
  • From March 1998 to March 2006, repair of the thoracic aorta using an ELG was performed on 406 patients at the Arizona Heart Institute, including 324 patients receiving a commercially available FDA-approved implant with the remaining patients receiving investigational devices. (bio-medicine.org)
  • Increases in promoters and reductions in inhibitors expand the thoracic aorta leading to TAA formation. (frontiersin.org)
  • Because the structure and embryologic origins of the cellular composition of the thoracic aorta are different from the abdominal aorta, this review will rely mainly on data from TAA and not from studies of the abdominal aorta aneurysms (AAAs). (frontiersin.org)
  • The major component of the media of the thoracic aorta is dozens of layers of "lamellar units" consisting's of two elastic lamellae and intervening tissue that are oriented in concentric layers around the lumen ( 4 , 5 ). (frontiersin.org)
  • Human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall, which is only some tens of microns in depth from surface. (spie.org)
  • Familial thoracic aortic aneurysm and dissection (Familial TAAD) is a rare condition that affects the aorta (the large blood vessel that distributes blood from the heart to the rest of the body). (nih.gov)
  • In people affected by this condition, the thoracic aorta (the upper part of the aorta, near the heart) may become weakened, stretched and/or enlarged. (nih.gov)
  • [1] [2] Treatment is generally based on the signs and symptoms present in each person and may include medications to reduce stress on the aorta and surgery to repair aortic abnormalities. (nih.gov)
  • Ascending Aorta - involvement from the aortic annulae to the innominate artery - is the most common. (cancertherapyadvisor.com)
  • Computed tomography (CT) scan with contrast is the most commonly used diagnostic test to evaluate the thoracic aorta and the abdominal aorta. (cancertherapyadvisor.com)
  • It is able to evaluate the size of the thoracic aortic aneurysm, the extent of the disease, and the distal portions of the aorta. (cancertherapyadvisor.com)
  • For example, anterior chest pain is usually associated with ascending aorta aneurysm. (cancertherapyadvisor.com)
  • Back pain between the scapula is usually a sign of descending aorta aneurysm. (cancertherapyadvisor.com)
  • Thoracic aorta aneurysm rupture is a medical emergency. (cancertherapyadvisor.com)
  • Most thoracic aortic aneurysms occur in the ascending aorta or the aortic arch. (cancertherapyadvisor.com)
  • Arteriosclerosis is the most common cause of thoracic aneurysm involving the descending aorta and aortic arch. (cancertherapyadvisor.com)
  • Ascending thoracic aorta aneurysm can be caused by cystic medial degeneration, genetics, familial, atherosclerosis, and infection such as syphilis. (cancertherapyadvisor.com)
  • Aortic aneurysm repair is surgery to fix a weak and bulging section of the aorta. (alberta.ca)
  • Sometimes this aorta gets enlarged due to the weakness of the artery walls, leading to a condition known as an aneurysm . (manipalhospitals.com)
  • This aneurysm can develop anywhere along the aorta. (manipalhospitals.com)
  • An aneurysm that occurs in the aorta located in the chest area is known as a thoracic aortic aneurysm . (manipalhospitals.com)
  • The balloon or bulging of the artery wall may be defined as a fusiform (uniform in shape) or a saccular (appears as lop-sided blister on one side of the aorta) aneurysm. (manipalhospitals.com)
  • Saccular aneurysm forms in the weakened area of the aorta wall. (manipalhospitals.com)
  • It is an aneurysm that starts in the ascending aorta and extends proximally as the aortic annulus and distally as the nominated artery. (manipalhospitals.com)
  • It is an aneurysm that occurs in the descending aorta and begins beyond the left subclavian artery. (manipalhospitals.com)
  • As the name implies, these aneurysms occurs in the arch of the aorta. (manipalhospitals.com)
  • There are several diseases of the thoracic aorta which can weaken the wall of this major blood vessel. (barnesjewish.org)
  • The heart pumps blood directly into the thoracic aorta, and the aorta then acts as a pipe to deliver blood to other blood vessels throughout the body. (barnesjewish.org)
  • Weakening of the wall of this blood vessel causes the aorta to bulge, and this bulge is known as a thoracic aortic aneurysm (TAA). (barnesjewish.org)
  • An open aneurysm repair is performed through a large incision in the chest, and the surgeon directly replaces the diseased portion of the aorta with a fabric-covered tube which is sewn into place. (barnesjewish.org)
  • Specifically designed for the thoracic aorta, the Relay device is offered in a wide range of sizes to help to expand the use of this minimally-invasive treatment for thoracic aortic aneurysms and penetrating atherosclerotic ulcers. (physiciansweekly.com)
  • After proximal aortic cross-clamping, veno-venous perfusion was switched to veno-arterial antegrade perfusion through the distal descending thoracic aorta to achieve spinal and visceral perfusion or through iliac arteries for distal perfusion combined with selective renovisceral blood perfusion. (uzh.ch)
  • What's the difference between thoracic aortic aneurysms and tortuous aorta? (healthtap.com)
  • We present the case of a 32-year-old man with a 10-cm aneurysm in the ascending aorta. (springer.com)
  • CT scan showing a large, thoracic aortic aneurysm (TAA) in the ascending aorta with a small aortic dissection that did not reach the sinus of Valsalva. (springer.com)
  • A thoracic aortic aneurysm is the swelling or ballooning of the aorta , the largest artery in the body, which carries oxygenated blood from the heart. (marketwired.com)
  • Approximately 40 percent of aneurysms in the aorta occur in the chest. (marketwired.com)
  • Thus, haploinsufficiency for TGFB2 predisposes to thoracic aortic disease, suggesting that the initial pathway driving disease is decreased cellular TGF-β2 levels leading to a secondary increase in TGF-β2 production in the diseased aorta. (nih.gov)
  • A thoracic aortic aneurysm is an aneurysm in the part of the aorta in the chest, situated above the diaphragm, a muscle that helps you breathe. (umcvc.org)
  • Ascending and arch aneurysms sometimes require complex surgical treatment, including the use of hypothermic circulatory arrest (HCA), a technique that utilizes very cold body temperatures to temporarily stop blood flow to the area of the aorta being operated on. (umcvc.org)
  • An aneurysm that bulges out like a balloon can develop at weak spots in the walls of the aorta. (veins1.com)
  • Aneurysm occurring in the weakened area of the upper part of the aorta is known as thoracic aortic aneurysm. (epainassist.com)
  • Aneurysms can develop anywhere in the aorta. (epainassist.com)
  • If the aneurysm is formed in the upper part of the aorta, they are known as thoracic aortic aneurysms. (epainassist.com)
  • Aneurysms commonly develop in the lower part of the aorta and are known as abdominal aortic aneurysms. (epainassist.com)
  • Aneurysms developing in between the upper and lower parts of the aorta are known as thoracoabdominal aneurysm and this type of aneurysm is rare. (epainassist.com)
  • Doctors may do surgery to insert a tube (graft) into your aorta to repair the aneurysm. (msdmanuals.com)
  • Which surgery you have depends on your age, health, and where your aneurysm is in your aorta. (msdmanuals.com)
  • A thoracic aortic aneurysm happens when the aorta in area of the chest called the thoracic cavity become too large. (myresults.org)
  • Imaging of the ascending thoracic aorta using echocardiogram, CT, or MRI scans. (myresults.org)
  • For all people with thoracic aortic aneurysm and dissection, surgery is recommended when the ascending aorta or aortic root reaches 5.0 cm, or if it is growing at a fast rate ( 0.5 cm per year). (myresults.org)
  • Untreated or unrecognized they can be fatal due to dissection or "popping" of the aneurysm leading to nearly instant death. (wikipedia.org)
  • The principal causes of death due to thoracic aneurysmal disease are dissection and rupture. (wikipedia.org)
  • citation needed] Atherosclerosis is the principal cause of descending aortic aneurysms, while aneurysms of the aortic arch may be due to dissection, atherosclerosis or inflammation. (wikipedia.org)
  • Among the recommendations: First-degree relatives of people with thoracic aortic aneurysm or dissection should have aortic imaging to identify asymptomatic disease. (wikipedia.org)
  • People with symptoms suggestive of thoracic aortic dissection should be routinely evaluated "to establish a pretest risk of disease that can then be used to guide diagnostic decisions. (wikipedia.org)
  • Thoracic Aortic Aneurysm at eMedicine Aneurysms: Aneurysms and Aortic Dissection at Merck Manual of Diagnosis and Therapy Home Edition Thoracic Aortic Disease - Northwestern Memorial Hospital. (wikipedia.org)
  • There is also increased risk of aortic dissection. (wikipedia.org)
  • Aortic dilatation is generally the first feature of familial TAAD to develop, although in some affected individuals dissection occurs with little or no aortic dilatation. (medlineplus.gov)
  • The dissection can also progress proximally, to involve the aortic sinus, aortic valve, and coronary arteries. (medscape.com)
  • This patient's marked aortic dilatation necessitates urgent planned surgery to prevent the risk of catastrophic dissection. (kevinmd.com)
  • It would be appropriate to use such therapy in a patient with Marfan syndrome with a smaller aortic root, but initiating this therapy now would not supplant surgical treatment, and no data indicate it would decrease the risk of dissection while awaiting surgery. (kevinmd.com)
  • The age at diagnosis of aortic root enlargement and/or dissection (dx. (jci.org)
  • A parent, sibling, or child who has a thoracic aortic aneurysm or who has experienced a dissection, rupture or unexplained sudden death. (hoag.org)
  • One of the nation s most respected treatment centers for thoracic aortic disorders has launched a Web site that provides information on virtually every aspect of the subject, including aortic aneurysm and aortic dissection, the catastrophic bleeding that reportedly took the life of actor John Ritter last week. (innovations-report.com)
  • He did research according to one article where he concluded (reached the opinion) that spikes in blood pressure seemed to precipitate dissection then rupture of aneurysm in a large amount of a group of 170 or so consecutive cases that came through his facility at Yale University's hospital. (healingwell.com)
  • The role of inflammation in type A aortic dissection: data of a pilot study," European Journal of Inflammation , vol. 11, pp. 269-278, 2013. (hindawi.com)
  • Familial Thoracic Aortic Aneurysm with Dissection Presenting as Flash Pulmonary Edema in a 26-Year-Old Man," Case Reports in Medicine , vol. 2014, Article ID 842872, 4 pages, 2014. (hindawi.com)
  • Surgery is also performed if a patient exhibits symptoms of aortic dissection, including sudden, severe, sharp or tearing pain across the chest or back. (reference.com)
  • Are the symptoms for aortic aneurysm and aortic dissection the same? (reference.com)
  • Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high mortality rates if undetected. (mdpi.com)
  • The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective" Biomolecules 10, no. 2: 182. (mdpi.com)
  • Over time, the blood vessel swells and is at risk for bursting, also called aortic dissection . (uhhospitals.org)
  • Therefore, there is a potential for rupture (bursting) or dissection (separation of the layers of the thoracic aortic wall), which may cause life-threatening hemorrhage (uncontrolled bleeding) and, potentially, death. (nyhq.org)
  • OBJECTIVES: Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection. (uniprot.org)
  • They are in agreement with recent data, proposing that the sterile inflammation and the related mediators, including cytokines, MMPs, and death mediator, are the shared pathological mechanism for the onset of type A aortic dissection (TAD) [19, 20]. (thefreelibrary.com)
  • Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. (carolineghetes.com)
  • A thoracic aortic aneurysm is a potentially life-threatening condition that involves a structural weakness of the aortic wall, which can lead to aneurysm, rupture, or dissection. (eurekaselect.com)
  • Ascending aneurysms can also cause additional heart conditions, such as a dissection, heart attack or stroke. (uchicagomedicine.org)
  • Despite high clinical frequencies, precise mechanism in development of aortic aneurysm and dissection remains largely unknown. (ahajournals.org)
  • Aortic aneurysm may present catastrophically with dissection or rupture or chronically with symptoms from compression of the surrounding structures. (bmj.com)
  • In-hospital mortality of 14.2%, being 50% in acute type A aortic dissection, 8.3% in chronic type A aortic dissection, 33.3% in chronic type B aortic dissection and 0% in complex aneurysms. (scielo.br)
  • Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm and dissection (TAAD). (jci.org)
  • Fbn1mgR/mgR mice with ascending aortic dissection and/or rupture had dramatically increased aggrecan staining compared with mice without these complications. (jci.org)
  • Thus, aggrecan and versican accumulation in ascending TAAD occurs via increased synthesis and/or reduced proteolytic turnover, and correlates with aortic dissection/rupture in Fbn1mgR/mgR mice. (jci.org)
  • RNA in situ hybridization (ISH) shows increased aggrecan and versican gene expression in human and mouse ascending thoracic aortic aneurysm and dissection (TAAD). (jci.org)
  • Case Report of a Hybrid Endovascular Approach to an Abdominal Aortic Dissection With Retrograde Thoracic Extension and Infrarenal Aneurysm. (biomedsearch.com)
  • Spontaneous abdominal aortic dissection (AAD) with retrograde thoracic extension is an extremely rare occurrence with a high mortality. (biomedsearch.com)
  • Abdominal aortic dissection can be associated with an abdominal aortic aneurysm (AAA) and the presence of an AAD with an AAA mandates surgical intervention because of a high rate of rupture. (biomedsearch.com)
  • Pre-AAArepair demographic, comorbid, and laboratory variables in 48 patients who had an aortic dissection or thoracic aortic aneurysm up to 25 years after AAA repair were compared with the same variables in 522 patients without such an event. (omicsonline.org)
  • It is also possible that onset of a thoracic aortic disease event such as Thoracic Aortic Aneurysm (TAA) or aortic dissection, the causes of which are similar to those of AAA, may affect the prognosis of a patient in whom AAA repair was performed years earlier [ 10 ]. (omicsonline.org)
  • However, the incidence of TAA and aortic dissection after AAA repair, the possible effect of these events on long-term post-repair survival, and factors associated with onset of thoracic aortic events after repair have not been well studied. (omicsonline.org)
  • We therefore assessed the effects on survival after AAA repair of onset of TAA or aortic dissection. (omicsonline.org)
  • Twenty-nine of these patients were subsequently excluded from the analysis because, at the time of their AAA repair, they had TAA or a history of TAA repair or aortic dissection. (omicsonline.org)
  • SM22α-deficient mice demonstrated pregnancy-induced aortic dissection, and SM22α deficiency worsened aortic aneurysm in Fbn1 C1039G/+ (Marfan) mice, validating this gene product as a TAA effector. (jci.org)
  • Among the women with pregnancies, 10 (10.6%) experienced a pregnancy‐related aortic complication (4 type A and 3 type B dissections, 1 coronary artery dissection, and 2 with significant [≥3 mm] aortic growth). (rti.org)
  • Five of 7 aortic dissections, including all 3 type B, and the coronary dissection (75% of all dissections) occurred in the postpartum period. (rti.org)
  • Conclusions Pregnancy in MFS is associated with an increased risk of aortic dissection, both types A and B, particularly in the immediate postpartum period. (rti.org)
  • Lack of knowledge of underlying MFS diagnosis before aortic dissection is a major contributing factor. (rti.org)
  • As an aneurysm can lead to a tear in the wall of the artery, it is also called as a thoracic aneurysm and aortic dissection, which leads to life-threatening bleeding. (manipalhospitals.com)
  • Thoracic aortic aneurysms may be related to hypertension, bicuspid aortic valves, inflammatory conditions, trauma or an underlying genetic disorder, such as Marfan syndrome , Loeys-Dietz aneurysm syndrome , Turner syndrome, familial thoracic aortic aneurysm and dissection syndrome , and vascular Ehlers-Danlos syndromes. (barnesjewish.org)
  • Aortic dissection and aortic rupture may be fatal and require emergency care at a center with expertise in the care of patients with these conditions. (barnesjewish.org)
  • Our center also participates in the International Registry of Acute Aortic Dissection and the Valve-Sparing Aortic Root Replacement Registry in Marfan Syndrome. (barnesjewish.org)
  • Several reports have indicated that a large aneurysm contributes to severe hypoxia or hemodynamic collapse without resulting in rupture or dissection of the aneurysm. (springer.com)
  • The University of Michigan is home to the International Registry of Aortic Dissection, and several research laboratories that are exploring the molecular etiologies of aortic diseases. (umcvc.org)
  • Thoracic aortic aneurysms (TAAD) develop asymptomatically until occurs aortic rupture or dissection often cause of morbidity. (alliedacademies.org)
  • A thoracic aortic aneurysm can also be termed as Thoracic Aneurysm and Aortic Dissection (TAAD), as aneurysm can also lead to a dissection, which means a tear in the artery wall, resulting in life-threatening bleeding. (epainassist.com)
  • Purpose:Thoracic aortic aneurysm and dissection (TAAD) is typically inherited in an autosomal dominant manner, but rare X-linked families have been described. (semanticscholar.org)
  • Several genes are linked to Familial Thoracic Aortic Aneurysm and Dissection (FTAAD). (myresults.org)
  • Other names for FTAAD are: thoracic aortic aneurysm (TAA), thoracic aortic aneurysm and dissection (TAAD), familial aortic aneurysm (FAA), and annuloaortic ectasia. (myresults.org)
  • Furthermore, we report for the first time that aortic dissection or surgery occurred significantly more often and earlier in probands with a class 4 or 5 pathogenic variant. (pubfacts.com)
  • The aneurysm tears open (called a rupture). (medlineplus.gov)
  • There is a risk that the aneurysm may open up (rupture) if you do not have surgery to repair it. (medlineplus.gov)
  • While aortic aneurysms are common worldwide, it is difficult to determine their exact prevalence because they usually cause no symptoms unless they rupture. (medlineplus.gov)
  • The larger the aneurysm, or the faster it grows, the more likely it is to rupture. (upmc.com)
  • The biggest threat posed by an aneurysm is rupture. (ucdavis.edu)
  • Aneurysms that have been discovered prior to rupture need to be measured, closely monitored and evaluated for treatment. (ucdavis.edu)
  • Most patients do not experience symptoms of a thoracic aortic aneurysm until it begins to leak, expand or rupture. (ucdavis.edu)
  • Thoracic aortic aneurysms (TAAs) are considered high risk for rupture if they are located below the aortic arch and greater than 6.5 centimeters in diameter, about the size of a lemon, or if the aneurysm is rapidly increasing in diameter (greater than 1 centimeter per year). (ucdavis.edu)
  • Foxe3 expression was induced in aortic SMCs after transverse aortic constriction, and Foxe3 deficiency increased SMC apoptosis and ascending aortic rupture with increased aortic pressure. (jci.org)
  • Thoracic aortic aneurysms are serious health risks because they can burst or rupture. (hoag.org)
  • Diagnosing a thoracic aneurysm is difficult because often there are no symptoms, and often the condition goes undiagnosed until a rupture occurs. (clevelandclinic.org)
  • Currently no conservative pharmacological approach exists that could slow down aneurysm progression and protect from the risk of acute rupture. (nih.gov)
  • The revealing symptom was hypertension in 12 cases, thoracic or abdominal pain in 7, isolated inflammatory syndrome in 5, neurologic or ocular manifestations in 3, rupture in 3, and embolization to the lower extremity in 1. (biomedsearch.com)
  • When dealing with patients who present with dysphagia, if no other cause is discovered, a thoracic aortic aneurysm should form part of the differential diagnosis, as this is potentially curable, and delays in diagnosis and treatment predispose to rupture and death. (nih.gov)
  • For intact, asymptomatic aneurysms the strongest determinant of rupture is the diameter. (sapbc.net)
  • Some surgeons also calculate the risk of aneurysm rupture by using the patient's height and the aneurysm size when deciding if surgery is needed. (reference.com)
  • Surgery can be life-threatening for many of these patients and a wait-and-see approach is often not an option because patients are at an increased risk of an aortic rupture. (innovations-report.com)
  • Specifically, the trial will assess device performance, as well as patient survival and aneurysm rupture rates in the surgical and endovascular treatment groups, over a 12-month period. (innovations-report.com)
  • Treatment for a thoracic aneurysm may include surgical repair or removal of the aneurysm to prevent rupture. (nyhq.org)
  • If a thoracic aortic aneurysm is found before it bursts or begins to leak, your care team will focus on preventing a rupture. (dignityhealth.org)
  • When making decisions about surgery, doctors balance the risks of major surgery versus the risks of aneurysm rupture. (dignityhealth.org)
  • Most thoracic aortic aneurysms do not have any symptoms until they begin to leak or fully rupture. (dignityhealth.org)
  • Pain is often associated with an imminent rupture of an aneurysm. (uchicagomedicine.org)
  • Risk of rupture is proportional to the size of the aneurysm. (merckmanuals.com)
  • Massive thoracic hemorrhage indicating aortic rupture was observed in 74% of dead mice (10/14). (ahajournals.org)
  • Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. (clinsci.org)
  • Thoracic aortic aneurysm, or "bulging" of the major artery which arises from the heart, is a serious condition prone to rupture and sudden death. (bio-medicine.org)
  • According to the Society for Vascular Surgery, less than half of all patients who experience a rupture of a thoracic aortic die before reaching the hospital, making it the 13th leading cause of death in the U.S. Furthermore, studies report that emergent, open surgical repair of a ruptured thoracic aneurysm carries a 25 to 50 percent risk of death. (bio-medicine.org)
  • The potentially high-mortality rate of thoracic aortic aneurysm (TAA) ( 1 , 2 ), highlights the need for a greater understanding of its pathophysiology so as to prevent TAA expansion and rupture. (frontiersin.org)
  • Aneurysm rupture presents with severe pain, hypotension, and shock. (cancertherapyadvisor.com)
  • The incidence of thoracic aneurysm is approximately 6 to 10 cases per 100,000 person years with the incidence of thoracic aneurysm rupture occurring in 3.5 per 100,000 persons. (cancertherapyadvisor.com)
  • Aneurysm rupture accounts for 60% of deaths. (cancertherapyadvisor.com)
  • Aneurysms associated with pain may pose a particular risk of rupture and should be evaluated promptly by a specialist. (barnesjewish.org)
  • To prevent the rupture of a large aneurysm, the weakened wall needs to be replaced with stronger tubing. (barnesjewish.org)
  • If not treated, the aneurysm can rupture, leading to internal bleeding which often is fatal. (marketwired.com)
  • Thoracic aortic aneurysms which are small and slow-growing may not ever rupture, but the larger and faster-growing aneurysms are at a risk for rupture and bleeding. (epainassist.com)
  • People with family history of aortic aneurysm are at increased risk of having one and these individuals also tend to develop aneurysms at a younger age and are at increased risk of rupture. (epainassist.com)
  • There are some aneurysms, which will never rupture. (epainassist.com)
  • If the risks of rupture are higher than those of intervention the aneurysm should be repaired. (oxfordmedicine.com)
  • Aortic dissections usually cause severe, sudden chest or back pain, and may also result in unusually pale skin (pallor), a very faint pulse, numbness or tingling (paresthesias) in one or more limbs, or paralysis. (medlineplus.gov)
  • Ruptured aortic aneurysms and dissections are estimated to cause almost 30,000 deaths in the United States each year. (medlineplus.gov)
  • However, aortic dissections may occur with medial degeneration in the absence of preexisting aneurysm. (medscape.com)
  • The Valiant stent-graft system is a flexible, implantable vascular stent-graft endoluminal device preloaded in a delivery system that is used to exclude thoracic aortic lesions (thoracic aneurysms, thoracic dissections, penetrating ulcers, traumatic transections and both traumatic and degenerative pseudoaneurysms. (clinicaltrials.gov)
  • Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of genetically triggered defects in aortic structure and a dysfunctional response to these forces. (jci.org)
  • Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections," The Journal of Thoracic and Cardiovascular Surgery , vol. 131, no. 3, pp. 671-678.e2, 2006. (hindawi.com)
  • A number of autosomal dominantly inherited disorders, such as Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), are associated with predisposition to thoracic aortic aneurysms and dissections (TAADs). (nature.com)
  • Aortic arch vessel geometries and deformations in patients with thoracic aortic aneurysms and dissections. (sigmaaldrich.com)
  • Scanning with electrocardiogram-gated computed tomography angiography during inspiratory and expiratory breath holds was performed in 15 patients (age, 64 y ± 14) with thoracic aortic aneurysms or dissections. (sigmaaldrich.com)
  • In patients with thoracic aortic aneurysms or dissections, the thoracic aortic arch translated significantly secondary to inspiration and expiration and to a lesser extent secondary to cardiac pulsation. (sigmaaldrich.com)
  • Risk factors for both TAAs and aortic dissections include prolonged hypertension , dyslipidemia , and smoking. (merckmanuals.com)
  • Risk factors for both thoracic aortic aneurysms and aortic dissections include prolonged hypertension , dyslipidemia , and smoking. (merckmanuals.com)
  • Tissue swelling imposed by aggrecan and versican is proposed to be profoundly deleterious to aortic wall mechanics and smooth muscle cell homeostasis, predisposing to type-A dissections. (jci.org)
  • The most commonly treated pathologies have been abdominal aortic aneurysm, iliac aneurysms, descending thoracic aortic aneurysms , and Type B dissections. (thefreedictionary.com)
  • These are known as thoracic aortic aneurysm (TAA), aortic dissections and aortic ulcerations. (barnesjewish.org)
  • Initially used for the repair of intact thoracic aneurysms and aortic dissections, TEVAR is now routinely used for the treatment of ruptured thoracic aortic aneurysm as well. (minervamedica.it)
  • A predisposition for thoracic aortic aneurysms leading to acute aortic dissections can be inherited in families in an autosomal dominant manner. (nih.gov)
  • FBN1 and TGFB1: Molecular mechanisms in the pathogenesis of thoracic aortic aneurysms and dissections. (alliedacademies.org)
  • Sepetiene R, Simonyte S. FBN1 and TGFß1: Molecular mechanisms in the pathogenesis of thoracic aortic aneurysms and dissections. (alliedacademies.org)
  • Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections. (semanticscholar.org)
  • Genetic diversity and pathogenic variants as possible predictors of severity in a French sample of nonsyndromic heritable thoracic aortic aneurysms and dissections (nshTAAD). (pubfacts.com)
  • Heritable thoracic aortic aneurysms and dissections (hTAAD) are life-threatening complications of well-known syndromic diseases or underdiagnosed nonsyndromic heritable forms (nshTAAD). (pubfacts.com)
  • Most deaths in patients with Marfan syndrome are the result of aortic disease. (wikipedia.org)
  • There is an association between familial thoracic aortic aneurysm and Marfan syndrome as well as other hereditary connective tissue disorders. (wikipedia.org)
  • One downside of the use of CT in detecting and following aortic aneurysms is the exposure to radiation, particularly for people who require frequent monitoring, such as those with Marfan syndrome. (mayoclinic.org)
  • Because of this, your doctor may recommend you have tests to check for thoracic aortic conditions if a first-degree relative, such as a parent, sibling, son or daughter, has Marfan syndrome or another condition that could cause a thoracic aortic aneurysm. (mayoclinic.org)
  • Your doctor may recommend that your first-degree relatives have an echocardiogram or another type of imaging test to check for Marfan syndrome or another thoracic aortic condition. (mayoclinic.org)
  • Oral losartan and metoprolol have both been used as part of a strategy to reduce the rate of aortic dilation in patients with Marfan syndrome. (kevinmd.com)
  • Surveillance echocardiography is not indicated because the aortic root already surpasses 5 cm, a size at which surgery is indicated in asymptomatic patients with Marfan syndrome. (kevinmd.com)
  • In patients with Marfan syndrome, repair is indicated for an asymptomatic thoracic aortic aneurysm with a root diameter greater than 5 cm. (kevinmd.com)
  • Our Center for Marfan and Aortic Disorders specializes in aortic conditions. (aurorahealthcare.org)
  • We analyzed the TGFB2 gene by sequencing in a cohort of 88 individuals with a Marfan-like phenotype and/or TAAD, who did not have mutations in known genes causing thoracic aortic disease. (nature.com)
  • Routine screening is warranted for the first-degree relatives of patients who present with thoracic aortic disease before age 60 years in the absence of predisposing conditions such as hypertension, Marfan syndrome, or bicuspid aortic valve, Dr. Elizabeth N. Robertson said at the American Heart Association scientific sessions. (ctsnet.org)
  • 2000 May;117(5):1271-8 Elefteriades published the natural history of TAAs and recommended elective repair of ascending aneurysms at 5.5 cm and descending aneurysms at 6.5 cm for patients without any familial disorders such as Marfan syndrome. (carolineghetes.com)
  • Here, we defined the aortic proteoglycanome using mass spectrometry, and based on the findings, investigated the large aggregating proteoglycans aggrecan and versican in human ascending TAAD and a mouse model of severe Marfan syndrome. (jci.org)
  • Ang II type 1a receptor (AT 1a R)-mediated activation of MAPKs contributes to thoracic aortic aneurysm (TAA) development in Marfan syndrome (MFS). (physiology.org)
  • This manuscript demonstrates that β-arrestin2 mediates thoracic aortic aneurysm formation in a murine model of Marfan syndrome (MFS) by regulating proaneurysmal signaling. (physiology.org)
  • Background The risk of aortic complications associated with pregnancy in women with Marfan syndrome (MFS) is not fully understood. (rti.org)
  • FBN1 (encoding fibrillin-1, causing Marfan syndrome), TGFBR1 and TGFBR2 (encoding transforming growth factor-β receptors I and II, causing Loeys-Dietz syndrome), and SMAD3 (encoding Mothers against decapentaplegic homolog 3, causing aneurysms-osteoarthritis syndrome). (ahajournals.org)
  • These data extend knowledge on the molecular pathways leading to sporadic thoracic disease and connect it with a model of Marfan syndrome. (alliedacademies.org)
  • Individuals who are born with Marfan syndrome, which is a genetic condition affecting the connective tissue, are at a higher risk for thoracic aortic aneurysm. (epainassist.com)
  • Individuals with connective tissue disorders (Marfan syndrome, Ehlers-Danlos syndrome) are at a significantly higher risk for developing thoracic aortic aneurysm. (epainassist.com)
  • An aneurysm is an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel. (medlineplus.gov)
  • By definition, an aneurysm is a localized or diffuse dilation of an artery with a diameter at least 50% greater than the normal size of the artery. (medscape.com)
  • Anatomically and radiologically, an aneurysm is defined as a dilatation at least 50% above the normal diameter of an artery. (medscape.com)
  • If the walls of the thoracic aortic become weak or injured, the artery may not be able to handle the normal force of blood pressing against it. (hoag.org)
  • This may result in a balloon-like bulge in the artery, known as a thoracic aortic aneurysm (TAA). (hoag.org)
  • By sealing the area tightly with your artery above and below the aortic aneurysm, the graft allows blood to pass through it without pushing on the aneurysm. (clevelandclinic.org)
  • This procedure makes blood vessels like your aortic artery easier to view. (aurorahealthcare.org)
  • Using a tiny, catheter tube, we insert a fabric-wrapped metal tube (stent-graft) to strengthen the weak spot in your thoracic aortic artery. (aurorahealthcare.org)
  • An aneurysm is a swelling of the the artery wall, and can be fatal if it ruptures. (sciencephoto.com)
  • The appearances of aortic root, aortic arch and thoracic artery aneurysms are varied. (radiopaedia.org)
  • Aneurysms are caused by a weakening in the artery wall that makes it balloon or bulge outward. (dignityhealth.org)
  • The left common carotid artery branch angled significantly more toward the aortic arch compared with the brachiocephalic artery and left subclavian artery (P (sigmaaldrich.com)
  • He underwent first stage surgery with aortic root and arch replacement, prosthetic aortic valve replacement, and coronary artery bypass grafting. (bmj.com)
  • The patient underwent first stage surgery in a different centre with ascending and total aortic arch replacement, prosthetic aortic valve replacement, and coronary artery bypass surgery, with a left internal mammary graft to the left anterior descending artery and a venous graft to the right coronary artery. (bmj.com)
  • An aneurysm is a dilation of an artery of at least 50% greater than the normal artery and can be either localized or diffuse. (cancertherapyadvisor.com)
  • After intravenous anesthesia, his aneurysm occluded the left main bronchus and right pulmonary artery simultaneously, and induced severe hypoxia. (springer.com)
  • Follow-up imaging shows thrombus lining the stent-graft-covered portion of the aneurysm and secondary proximal segmental artery occlusion. (lu.se)
  • To our surprise, Contrast Enhanced Computed Tomography (CECT) revealed partially thrombosed saccular thoracic aneurysm originating distal to origin of left subclavian artery. (jcdr.net)
  • An aneurysm is a bulge in an artery wall. (msdmanuals.com)
  • Treatment of AAAs, TAAAs, and TAAs involves surgical repair in good-risk patients with aneurysms that have reached a size sufficient to warrant repair. (medscape.com)
  • Descending thoracic aortic aneurysms (TAAs) and thoracoabdominal aortic aneurysms (TAAAs) often go unnoticed, yet early diagnosis is critical to managing these conditions. (upmc.com)
  • Indications for surgical treatment of thoracic aortic aneurysms (TAAs) are based on size or growth rate and symptoms. (carolineghetes.com)
  • In this issue of Circulation Research , Hofmann Bowman et al 2 provide evidence for a new pathological role of S100A12 in the development of thoracic aortic aneurysms (TAAs). (ahajournals.org)
  • TAAs are frequently associated with a number of well-defined genetic determinants, although there remains many questions regarding the mechanistic basis for the development and propagation of aneurysms in this region. (ahajournals.org)
  • The accumulation of S100A12 protein in mouse aortas and cultured aortic SMCs was equivalent to extracts of human TAAs and SMCs cultured from human TAAs. (ahajournals.org)
  • It has been suggested that the disruption of the connection between smooth muscle cells (SMCs) and elastic fibers in the aortic wall impacts SMC's ability to sense and respond to mechanical forces, which may cause TAAs. (brightsurf.com)
  • TAAs account for one fourth of aortic aneurysms. (merckmanuals.com)
  • Additional risk factors for TAAs include presence of aneurysms elsewhere in the body, infection, aortitis , and older age (peak incidence at age 65 to 70). (merckmanuals.com)
  • AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal diseases in humans that appear to have distinct pathologies and mechanisms. (clinsci.org)
  • The leading cause of death in MFS is secondary to complications related to the development of thoracic aortic aneurysms (TAAs) ( 6 ). (physiology.org)
  • Degenerative TAAs develop during processes in which factors leading to aneurysm formation overcome factors, which retard TAA development. (frontiersin.org)
  • Thoracic aortic aneurysms (TAAs) present a major group of diseases of cardiovascular pathology affecting 5.9:100,000 worldwide [ 1 ]. (alliedacademies.org)
  • Idiopathic, noninflammatory aneurysms are associated with congenital conditions (bicuspid aortic valve) and acquired conditions (hypertension). (medscape.com)
  • Many cases of ascending thoracic aortic aneurysms are associated with an underlying bicuspid aortic valve. (ahajournals.org)
  • Additionally, the congenital bicuspid aortic valve (BAV) leads to a distinct extracellular matrix structure that may be related to ATAA development at an earlier age than degenerative aneurysms arising in patients with the morphological normal tricuspid aortic valve (TAV). (nih.gov)
  • Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms. (uniprot.org)
  • We hypothesize that genotypic variations in patients with bicuspid aortic valves contribute to this observed variability in aortic phenotype. (uniprot.org)
  • We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. (uniprot.org)
  • METHODS: We performed a targeted mutational analysis of NOTCH1 using genomic DNA from 48 unrelated subjects with concomitant bicuspid aortic valve and thoracic aortic aneurysm using denaturing high-performance liquid chromatography and DNA sequencing. (uniprot.org)
  • We focused on exons in which mutations associated with bicuspid aortic valve have been reported previously. (uniprot.org)
  • Results were compared with control subjects with trileaflet aortic valves (n = 94), bicuspid aortic valves, and normal aortas (n = 22) and in subjects with tricuspid aortic valves and thoracic aortic aneurysms (n = 28). (uniprot.org)
  • RESULTS: Four unique, nonsynonymous (3 novel) variants were identified in 5 (10.4%) of 48 patients with concomitant bicuspid aortic valves and thoracic aortic aneurysms compared with only 3 (2.1%) of 144 control subjects (P = .02). (uniprot.org)
  • Of these, 2 novel missense mutations, A1343V and P1390T, were observed only in patients with bicuspid aortic valves and tricuspid aortic aneurysms. (uniprot.org)
  • CONCLUSIONS: This targeted analysis involving NOTCH1 exons previously implicated in familial and sporadic bicuspid aortic valve demonstrates overrepresentation of NOTCH1 missense variants among patients with bicuspid aortic valves and thoracic aortic aneurysms. (uniprot.org)
  • The primary objective of the trial is to compare the composite outcome of the all-cause mortality and incidence of acute aortic events between surveillance and elective ascending aortic surgery for patients with degenerative or bicuspid valve-related ascending aortic aneurysm after 2 years of follow up. (centerwatch.com)
  • He had a history of aortic valve stenosis (bicuspid valve) and reduced LV ejection fraction (EF, 40%) at the age of 5 years. (springer.com)
  • Individuals with aortic valve problems, such as bicuspid aortic valve, are at an increased risk of thoracic aortic aneurysm. (epainassist.com)
  • Endovascular repair of thoracic aortic aneurysms has become a viable, less invasive alternative to open thoracic repair. (sapbc.net)
  • Fig 2 A, Graphic plot of change in aneurysm sac diameter over time after endovascular repair of thoracic aortic aneurysms (TEVAR) in patients with postoperative type I endoleaks. (carolineghetes.com)
  • How often you have these tests done depends … Fig 2 A, Graphic plot of change in aneurysm sac diameter over time after endovascular repair of thoracic aortic aneurysms (TEVAR) in patients with postoperative type I endoleaks. (carolineghetes.com)
  • Siyamek Neragi-Miandoab and Thomas Bernik, " Endovascular Repair of Thoracic Aortic Aneurysms", Recent Patents on Cardiovascular Drug Discovery (Discontinued) (2009) 4: 211. (eurekaselect.com)
  • Today marks the beginning of a new era of less-invasive repair of thoracic aortic aneurysm, which will provide a safer alternative to regular surgery in some patients. (veins1.com)
  • Indication for surgery may depend upon the size of the aneurysm. (wikipedia.org)
  • Despite the size of the aneurysm, patients may require surgery if their aneurysms cause symptoms such as chest, jaw, upper back or neck pain, explains Cleveland Clinic. (reference.com)
  • Your team will work together to develop a personalized treatment plan that takes into consideration the size of the aneurysm and how fast it's growing as well as your personal needs and lifestyle. (uhhospitals.org)
  • These results demonstrate that increased collagen α1(XI) and collagen V mRNA and protein levels are linearly correlated with the size of the aneurysm and provide a potential mechanism for the generation and progression of aneurysmal enlargement. (harvard.edu)
  • Thoracic aortic aneurysm (TAA) shares risk factors with atherosclerosis, or hardening of the arteries. (ucdavis.edu)
  • Estimated population prevalence ranges between 1:5000 and 1:4 000 000 in adults depending on the occurrence of an isolated thoracic aortic aneurysm or as a symptom of a syndromic disorder, excluding non-genetic causes, for example, atherosclerosis. (nature.com)
  • Atherosclerosis, which is hardening of arteries due to buildup of plaques, damages the lining of the blood vessel and increases the risk of an aneurysm. (epainassist.com)
  • Thoracic aortic aneurysms may be asymptomatic (without symptoms) or symptomatic (with symptoms). (nyhq.org)
  • Patients between the age of 18 and 79 with an asymptomatic ascending aortic aneurysm between 5.0 cm and 5.4 cm in maximal diameter are entered into the randomization study. (centerwatch.com)
  • Thoracic aortic aneurysms are slow growing and often asymptomatic, which makes them difficult to identify. (uchicagomedicine.org)
  • In this case, we report unexpected cardiopulmonary collapse manifested by general anesthesia before surgery in an asymptomatic patient with a large thoracic aortic aneurysm. (springer.com)
  • It is important to recognize that fatal organ compression might be caused by general anesthesia even in asymptomatic patients with thoracic aortic aneurysm. (springer.com)
  • Most descending thoracic aortic aneurysms (TAA) are asymptomatic, being discovered incidentally on chest X-rays and computed tomography scans. (oxfordmedicine.com)
  • Most people have no symptoms until the aneurysm begins to leak or expand. (medlineplus.gov)
  • Aortic aneurysms usually have no symptoms. (medlineplus.gov)
  • Patients with idiopathic, noninflammatory aneurysms are typically adults and present with symptoms of aneurysm later than do those patients with identified connective tissue disorders. (medscape.com)
  • The patient has no symptoms suggesting an acute aortic syndrome, and immediate hospitalization, emergency surgery, and parenteral agents to control blood pressure or heart rate are not indicated. (kevinmd.com)
  • If your aneurysm is small and not causing symptoms, your doctor may choose to monitor your condition. (upmc.com)
  • When symptoms do appear, the location of the aneurysm will determine the kind of symptoms that are experienced by the patient. (ucdavis.edu)
  • What are the symptoms of a thoracic aneurysm? (hopkinsmedicine.org)
  • What are the symptoms of an abdominal aneurysm? (hopkinsmedicine.org)
  • Very few people with thoracic aortic aneurysm notice symptoms. (hoag.org)
  • If you don't have any symptoms, but you're at risk for developing aneurysms (for instance, you smoke or are an older male), your Aurora medical team may talk with you about it. (aurorahealthcare.org)
  • Can aortic aneurysm symptoms go away and come back? (reference.com)
  • Symptoms of an aortic aneurysm may come and go, or they may be constant, explains WebMD. (reference.com)
  • Aneurysms symptoms aren't easily noticed, even if they're large, making it especially important for patients to understand and manage risk factors for aneurysm. (uhhospitals.org)
  • Because an aneurysm usually has no symptoms, it may be diagnosed during a routine medical test, such as a chest X-ray or ultrasound of the heart or abdomen. (uhhospitals.org)
  • Symptoms of a thoracic aneurysm may be related to the location, size, and growth rate of the aneurysm. (nyhq.org)
  • Most thoracic aortic aneurysms do not cause symptoms and are not detectable on a routine physical examination. (barnesjewish.org)
  • Often, there are no symptoms, so most people won't know if they have an aortic aneurysm until it ruptures. (marketwired.com)
  • Only half of all people who have thoracic aortic aneurysms notice any symptoms. (umcvc.org)
  • Thoracic aortic aneurysm usually grows slowly and often without symptoms and this makes it difficult to detect. (epainassist.com)
  • You may not have symptoms, even if your aneurysm is very big. (msdmanuals.com)
  • An aortic aneurysm does not usually have symptoms. (myresults.org)
  • citation needed] The diagnosis of thoracic aortic aneurysm usually involves patients in their 60s and 70s. (wikipedia.org)
  • Early diagnosis of a thoracic aneurysm is critical to managing the condition. (clevelandclinic.org)
  • 2010 F/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease representative members, 2014 AHA/ACC guideline for the management of patients with valvular heart disease representative members, Sundt TM 3rd," The Journal of Thoracic and Cardiovascular Surgery , vol. 151, no. 4, pp. 959-966, 2016. (hindawi.com)
  • Due to the serious risks it presents, timely diagnosis and treatment of a thoracic aneurysm are critical. (clevelandclinic.org)
  • Learn more about TEVAR as part of our thoracic aortic aneurysm diagnosis and treatment options. (aurorahealthcare.org)
  • The GenTAC Registry facilitated research in the diagnosis and clinical care of people who have genetically triggered thoracic aortic aneurysm. (nih.gov)
  • By providing clinical and biological data, the GenTAC Registry is helping improve the diagnosis and clinical care of genetically triggered thoracic aortic aneurysms and their complications, especially those affecting the cardiovascular system. (nih.gov)
  • These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. (spiedigitallibrary.org)
  • The correlation of the co-occurrence matrix attains a sensitivity of 0.906 and specificity of 0.864 when aneurysm automatic diagnosis is evaluated with a receiver operating characteristic curve. (spiedigitallibrary.org)
  • The resulting images require a suitable processing to enhance interesting disorder features and to use them as indicators for wall degradation, converting OCT into a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. (spie.org)
  • Pseudoaneurysms may result from aortic tears, typically due to blunt chest trauma , with healing of the extravasated blood and formation of fibrous tissue wall. (medscape.com)
  • Thoracic aortic aneurysms are often found during routine medical tests, such as a chest X-ray, CT scan, or ultrasound of the heart or abdomen, sometimes ordered for a different reason. (mayoclinic.org)
  • Your doctor may first suspect you have a thoracic aortic aneurysm by looking at chest X-ray images. (mayoclinic.org)
  • Computed tomography scan of the chest showing a thoracic aortic aneurysm (4 × 6 cm, arrow) with a heterogeneous mass in the left upper lobe consistent with a large hematoma. (cmaj.ca)
  • Thoracic aortic aneurysms are identified and/or confirmed through X-ray and chest CT scans, which can also be used to measure the diameter of the aneurysm and its exact location. (ucdavis.edu)
  • The term "thoracic" refers to your chest. (aurorahealthcare.org)
  • Depending on the aneurysm's location, thoracic aortic aneurysm surgery usually requires an incision in the front of the chest or the left side of the chest, according to Cleveland Clinic. (reference.com)
  • The typical treatment options for aneurysms near the heart are medications and two types of surgery: open abdominal or open chest repair and endovascular r. (reference.com)
  • A thoracic aortic aneurysm is located in the chest area. (nyhq.org)
  • Frontal chest X-ray reveals an abnormal shape to the aortic knuckle, with peripheral calcification and smooth margins. (radiopaedia.org)
  • A weakening or bulging of the descending aortic wall located in the back of the chest cavity. (uchicagomedicine.org)
  • Thoracic aneurysm is usually discovered after a chest X-ray or other radiographic study. (cancertherapyadvisor.com)
  • Thoracic aortic aneurysms may be uncovered by chest X-ray, but imaging such as echocardiogram, CT scan and MRI scan are necessary for complete evaluation. (barnesjewish.org)
  • Aneurysms may cause chest or back pain which could be a sign that the wall is too weak to support the pressure of the blood inside. (barnesjewish.org)
  • The most frequent chest X-ray finding fo descending thoracic aortic aneurysm is an enlargement of medial mediastinum. (minervamedica.it)
  • Similarly, patients with thoracoabdominal aneurysms (aneurysms that coexist in both the chest and the abdomen) may also be candidates for the debranching option, which also eliminates the need for a large thoracoabdominal incision. (umcvc.org)
  • Most non-leaking thoracic aortic aneurysms are detected by tests -- usually a chest X-ray or a chest CT scan -- run for other reasons. (veins1.com)
  • Chest or back pain may indicate an acute expansion or leakage of an aneurysm. (veins1.com)
  • Thoracic aortic aneurysms are usually detected during routine medical exams, such as a chest X-ray or ultrasound of the heart or the abdomen. (epainassist.com)
  • Thoracic has to do with the chest (thorax). (msdmanuals.com)
  • A thoracic stent graft (20) has a tubular bio-compatible graft material body (22) with a lumen therethrough with a proximal end (26) and a distal end (27). (google.es)
  • The thoracic stent graft can be in one or two portions. (google.es)
  • 1 . A thoracic stent graft having a tubular bio-compatible graft material body with a lumen therethrough and having a proximal end and a distal end, a sealing stent at the proximal end of the tubular body and an anchoring device affixed to the sealing stent. (google.es)
  • 3 . A thoracic stent graft as in claim 2 wherein the anchoring device extends from the sealing stent and through the graft material body. (google.es)
  • 4 . A thoracic stent graft as in claim 1 wherein the anchoring device extends towards a distal end of the tubular body. (google.es)
  • 5 . A thoracic stent graft as in claim 1 wherein the anchoring device comprises a plurality of barbs extending distally. (google.es)
  • 6 . A thoracic stent graft as in claim 1 further including a distal attachment stent affixed to and extending from the distal end of the graft material body. (google.es)
  • 7 . A thoracic stent graft as in claim 6 wherein the distal attachment stent includes at least one anchoring device affixed thereto and extending proximally. (google.es)
  • 8 . A thoracic stent graft as in claim 7 wherein the at least one anchoring device is a barb. (google.es)
  • 9 . A thoracic stent graft as in claim 1 further including one or more intermediate stents positioned between the proximal sealing stent and the distal end. (google.es)
  • 10 . A thoracic stent graft as in claim 9 wherein at least some of the one or more of the intermediate stents are on the outside surface of the tubular body. (google.es)
  • 11 . A thoracic stent graft as in claim 9 wherein the stents are self-expanding stents. (google.es)
  • 13 . A thoracic stent graft as in claim 9 wherein the intermediate stents are spaced apart to allow for bending of the stent graft. (google.es)
  • 14 . A thoracic stent graft as in claim 9 wherein the intermediate stents are spaced apart from five to ten millimetres. (google.es)
  • 15 . A thoracic stent graft as in claim 1 wherein the graft material is selected from at least one of polyester, expanded polytetrafluoroethylene or extra-cellular matrix. (google.es)
  • 17 . A thoracic stent graft as in claim 16 wherein the first portion includes at least one internal sealing stent at its distal end. (google.es)
  • 18 . A thoracic stent graft as in claim 16 wherein the second portion includes at least two internal sealing stents at its proximal end. (google.es)
  • 19 . A thoracic stent graft as in claim 16 wherein the first portion and the second portion have respective lengths to provide at least an overlap of two sealing stents. (google.es)
  • 20 . A thoracic stent graft as in claim 1 wherein the tubular body has a length of from 75 to 240 mm and a diameter of from 22 to 42 mm. (google.es)
  • 21 . A thoracic stent graft as in claim 16 wherein the first portion and the second portion when assembled together have a combined length in use of from 150 to 350 mm and a diameter of from 22 to 42 mm. (google.es)
  • Subject's anatomy is suitable for placement of the TALENT endoluminal stent-graft, with a distinct proximal aneurysm neck of 10 mm or more in length and a distal aneurysm neck of at least 10 mm. (clinicaltrials.gov)
  • Through small incisions in the groin, the catheters are used to guide and deliver a stent-graft through the blood vessels to the site of the aneurysm. (clevelandclinic.org)
  • Endovascular treatment involves delivery of a stent graft over a guidewire and deployment above and below the aneurysm. (sapbc.net)
  • 'A systematic review of the recent evidence for the efficacy and safety relating to the use of endovascular stent-graft (ESG) placement in the treatment of thoracic aortic disease' , April 2005. (nice.org.uk)
  • Bolton Medical announced today that they have received approval from the U.S. Food and Drug Administration for the Relay Thoracic Stent-Graft with Plus Delivery System. (physiciansweekly.com)
  • Associate Professor of Surgery and Radiology stated, "The Relay Thoracic Stent-Graft allows for precision and conformability, especially in patients with more challenging anatomies. (physiciansweekly.com)
  • We believe that U.S. physicians will benefit tremendously from access to the latest medical technology of the Relay Thoracic Stent-Graft with Plus Delivery System," said Oscar Rospigliosi, CEO, Bolton Medical, Inc. (physiciansweekly.com)
  • Technique: A thoracic stent-graft that flares out to a maximum of 51 mm is deployed in a standard fashion covering all segmental arteries where graft-wall apposition occurs in the first ~20 cm of the aneurysm. (lu.se)
  • In some individuals with a thoracic aortic aneurysm, an underlying cause is Marfan's Syndrome, a connective-tissue disorder that results in the characteristic weakening of the aortic wall. (ucdavis.edu)
  • Medial degeneration leads to weakening of the aortic wall, which in turn results in aortic dilatation and aneurysm formation. (ahajournals.org)
  • Thoracoabdominal aortic aneurysms (TAAA) are less common. (upmc.com)
  • CONCLUSIONS: Transfemoral veno-venous cooling and re-warming results in remarkable hemodynamic stability during open repair of thoracic- and/or thoracoabdominal aortic aneurysms and eliminates the need for retrograde arterial perfusion and its inherent risks. (uzh.ch)
  • Subject has a proximal and distal aortic neck diameter ≥ 18 mm and ≤ 42 mm. (clinicaltrials.gov)
  • 5.4 x 5.7 cm proximal descending thoracic aortic aneurysm. (radiopaedia.org)
  • Surgeons consider aneurysm repair surgery when the TAA or TAAA becomes large. (upmc.com)
  • It is therefore important that cardiologists acquire a sufficient knowledge base so that they can confidently evaluate and manage patients with aortic disease and know when it is appropriate to refer them for surgery. (ahajournals.org)
  • Assistant Professor of Surgery Christopher Abularrage and Associate Professor of Surgery James Black discuss abdominal and thoracic aortic aneurysms. (hopkinsmedicine.org)
  • I hope we will be able to help many patients who have been unable to find reliable information on the Internet and in their communities," said Sharo Raissi, M.D., director of Thoracic Aortic Surgery at Cedars-Sinai Medical Center. (innovations-report.com)
  • According to Dr. Raissi, one of the more dramatic breakthroughs of the past 10 years has significantly dropped the mortality and long-term disability risks for patients undergoing surgery to replace a damaged section of the descending aortic aneurysm. (innovations-report.com)
  • Despite the extent of aneurysmal lesions and high frequency of association with visceral and supraaortic vessel lesions, the outcome of surgery in patients presenting with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease was satisfactory. (biomedsearch.com)
  • Learn more about aneurysm surgery . (aurorahealthcare.org)
  • STARZ-TX2 will compare the outcomes of patients treated with open surgery to patients treated with the Zenith TX2 Thoracic TAA Endovascular Graft, manufactured by Cook Incorporated. (innovations-report.com)
  • View our YouTube playlist , which highlights genetics, imaging, and surgery options for thoracic aortic disease and research done using GenTAC data, biospecimens, or images. (nih.gov)
  • While the goal of aneurysm treatment is to prevent it from rupturing, it doesn't always mean surgery. (uhhospitals.org)
  • Cardiovascular surgeons face certain challenges in open surgery: to prevent postoperative pseudoaneurysm formation if the graft is sutured close to a degraded aortic wall and to be able to evaluate the quality of the aortic arch to extend the graft placement if necessary. (spiedigitallibrary.org)
  • This is a prospective, multi-centre randomized control trial that compares the all-cause mortality, aneurysm-related aortic events, rate of stroke, and quality of life for those patients undergoing early elective ascending aortic surgery to those patients undergoing surveillance. (centerwatch.com)
  • Patients referred for an ascending aortic aneurysm that meets the inclusion criteria will be randomized to the early elective surgery group or the surveillance group. (centerwatch.com)
  • The hypothesis is that the early surgery group will have a significantly lower all-cause mortality and incidence of acute aortic events at 2 years of follow up compare to the surveillance group. (centerwatch.com)
  • The types of surgery (ascending aortic replacement, Bentall procedure, valve-sparing root replacement, etc.) will be at the discretion of the surgeon. (centerwatch.com)
  • Surgery is the alternative option, with a higher threshold of aortic dimensions for intervention.1 It is done by thoracotomy and often without cardiopulmonary bypass while protecting the spinal cord. (carolineghetes.com)
  • Endovascular stenting has emerged as an alternative to open repair in patients requiring surgery for thoracic aortic pathology. (eurekaselect.com)
  • Continuous Surveillance of Lower Limb Perfusion During Aortic Surgery With Near-Infrared Spectroscop. (biomedsearch.com)
  • Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients," The Journal of Thoracic and Cardiovascular Surgery, vol. (thefreedictionary.com)
  • Aortobronchial and aortoesophageal fistulae as risk factors in surgery of descending thoracic aortic aneurysms ," European Journal of Cardio-Thoracic Surgery, vol. (thefreedictionary.com)
  • The Annals of Thoracic Surgery 88 (2) (August): 506-513. (harvard.edu)
  • PHOENIX, Sept. 28 /PRNewswire/ -- The Arizona Heart Institute announced today that results from its single-center study of the effectiveness of endoluminal grafting for thoracic aortic pathologies were published in the September 2007 issue of the Journal of Vascular Surgery. (bio-medicine.org)
  • In our center, a multidisciplinary approach to the evaluation and management of thoracic aortic disease is offered, involving specialists from cardiac and vascular surgery, cardiology, medical genetics and radiology. (barnesjewish.org)
  • If surgery is not necessary, the aneurysm is routinely checked by echocardiograms, CT and MRI scans to monitor its growth. (barnesjewish.org)
  • Endovascular aneurysm repair uses smaller incisions in the lower abdomen or groin, and the tubing is advanced into the aneurysm using x-rays to direct the surgery. (barnesjewish.org)
  • However, compared to open surgery, endovascular aneurysm repair often results in quicker recovery following surgery. (barnesjewish.org)
  • Dr Rai special interest lies in Carotid Surgery, Aortic Aneurysm Repair (open & EVAR), Peripheral Bypass Surgery (aorto-femoral, fem-distal) and Dialysis Access Surgery (Fistula/Grafts). (vaidam.com)
  • He has pioneered a new Aortic No touch technique in CABG which eliminates the risk of stroke - one of the most dreaded complications of Bypass Surgery. (indiamart.com)
  • For many patients with thoracic aortic aneurysms, thoracic endovascular aortic repair (TEVAR) has emerged as a solid alternative to conventional open-heart surgery. (umcvc.org)
  • Using a collaborative approach to care, our surgeons and cardiologists will monitor the progression of these aneurysms until surgery is determined to be necessary. (umcvc.org)
  • Patients with extensive aortic disease may require a hybrid approach, a combination of open surgery and endovascular repair. (umcvc.org)
  • While traditional surgery can repair thoracic aortic aneurysms (if they are detected in time) interventional radiology is once again paving the way toward new minimally invasive techniques. (veins1.com)
  • If you have a larger aneurysm, you'll need surgery. (msdmanuals.com)
  • If your aneurysm bursts or is about to burst, emergency surgery to fix it may save your life. (msdmanuals.com)
  • If you have a family history of aneurysm or another suspected genetic condition that raises your risk of thoracic aortic aneurysm, you may want to consider genetic testing. (mayoclinic.org)
  • 1,6 The extent of genetic heterogeneity is likely to become more evident as more families with thoracic aortic aneurysms are studied. (ahajournals.org)
  • What role do high cholesterol or genetic disorders play in aneurysms? (hopkinsmedicine.org)
  • C. R. Balistreri, "Genetic contribution in sporadic thoracic aortic aneurysm? (hindawi.com)
  • Aneurysms can be caused by a variety of factors, including health/lifestyle factors, conditions that weaken your arteries or genetic conditions. (aurorahealthcare.org)
  • The purpose of the GenTAC Registry was to collect data and specimens from patients who had a confirmed or suspected genetic condition that increased their chances of developing thoracic aortic aneurysms . (nih.gov)
  • The Registry enrolled over 3,600 people who had one of the 13 conditions with a genetic risk of developing thoracic aortic aneurysm and its complications. (nih.gov)
  • From 2009 to 2016, the GenTAC Registry held four scientific meetings called Aortic Summits, which help bring together clinical, translational, and basic scientists who research the genetic and other factors involved in the mechanisms of thoracic aortic disease, as well as its progression and treatment. (nih.gov)
  • GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. (clinicaltrials.gov)
  • Screening for thoracic aneurysm involves obtaining a detailed family history to rule out genetic or familial disorders. (cancertherapyadvisor.com)
  • If genetic test results suggest a person is found to be at risk of developing familial thoracic aortic aneurysm, regular health checks are recommended. (myresults.org)
  • Determine the proportion in whom successful implantation is achieved, as indicated by aneurysm exclusion and graft patency. (clinicaltrials.gov)
  • The clinical trial, called STARZ-TX2 (Study of Thoracic Aortic Aneurysm Repair with the Zenith® TX2™ Thoracic TAA Endovascular Graft), is open to patients diagnosed with a descending thoracic aortic aneurysm. (innovations-report.com)
  • It was 9.5% of reoperations and 38% of associated procedures (25.3% miocardial revascularization, 25.3% replacement of aortic valve and 49.4% aortic valved graft). (scielo.br)
  • In our research findings and overall experience with thoracic endoluminal graft (ELG) repair, we see a significantly less overall complication rate, including death, compared to published adverse events associated with open surgical repair," continued Rodriguez. (bio-medicine.org)
  • Most recently, 72-year-old Malcolm Langston of Etowah, North Carolina received the first FDA-approved graft to treat a thoracic aortic aneurysm. (veins1.com)
  • During a two hour procedure, the vascular experts threaded the catheter to the thoracic aortic aneurysm where they then unfurled the Gore TAG graft at the site. (veins1.com)
  • Sixteen patients out of these eighty-eight individuals showed clinical features overlapping with syndromic/familial forms of TAAD including vascular type of the Ehlers-Danlos syndrome (MIM 130050), aortic valve disease (MIM 109730), arterial tortuosity syndrome (MIM 208050), aneurysms-osteoarthritis syndrome (MIM 613795), familial thoracic aortic aneurysm 6 (MIM 611788) and/or familial thoracic aortic aneurysm 4 (MIM 132900). (nature.com)
  • There is also a weak association of acute aortic syndromes with fluoroquinolones, so avoidance may be considered.34. (carolineghetes.com)
  • Acute aortic syndromes and thoracic aortic aneurysm. (carolineghetes.com)
  • Acute TBAD with complications should be repaired with emergent thoracic endovascular aortic repair (TEVAR). (carolineghetes.com)
  • Play media Guidelines were issued in March 2010 for early detection of thoracic aortic disease, by the American College of Cardiology, the American Heart Association, and other groups[citation needed]. (wikipedia.org)
  • The long-term outlook for people with thoracic aortic aneurysm depends on other medical problems, such as heart disease, high blood pressure, and diabetes. (medlineplus.gov)
  • Aortic root dilatation is typical of the disease, and the murmur heard on physical examination represents aortic regurgitation. (kevinmd.com)
  • At the UPMC Heart and Vascular Institute's Center for Thoracic Aortic Disease , our multidisciplinary approach to care offers patients many benefits. (upmc.com)
  • The latest cardiovascular research to advance patient care and form new strategies to better manage thoracic aortic disease. (upmc.com)
  • To refer a patient , contact the UPMC Center for Thoracic Aortic Disease . (upmc.com)
  • Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression. (nih.gov)
  • Non-coding RNAs involved in vascular disease and aortic aneurysms. (nih.gov)
  • Age-related changes in aortic 3D blood flow velocities and wall shear stress: implications for the identification of altered hemodynamics in patients with aortic valve disease," Journal of Magnetic Resonance Imaging , vol. 43, no. 5, pp. 1239-1249, 2016. (hindawi.com)
  • There are several causes of abdominal aortic aneurysm, but the most common results from atherosclerotic disease. (mountsinai.org)
  • Descending thoracic and thoracoabdominal aortic aneurysm in patients with Takayasu's disease. (biomedsearch.com)
  • From June 1974 to December 2001 we performed operative treatment on 33 patients with descending thoracic or thoracoabdominal aortic aneurysm in association with Takayasu disease. (biomedsearch.com)
  • As the resulting protein is unlikely functional and by considering data from the literature, we support the notion that functional haploinsufficiency for TGF- β 2 predisposes to thoracic aortic disease. (nature.com)
  • In these cases, we excluded mutations in clinically relevant, aortic disease-associated genes including COL3A1 (10 probands), ACTA2 (9 probands), SMAD3 (8 probands), SLC2A10 (3 probands), NOTCH1 (8 probands) and/or MYH11 (5 probands). (nature.com)
  • The data and specimens help physicians and researchers clarify the link between aortic disease and phenotypic and genotypic information. (nih.gov)
  • Read more about how the GenTAC Registry continues to increase knowledge about thoracic aortic disease through Aortic Summits. (nih.gov)
  • Thoracic aortic aneurysms may be caused by different disease processes, especially in respect to their location. (nyhq.org)
  • This review summarizes the current understanding of the inherited basis for aortic aneurysmal disease and clearly highlights the need to differentiate between thoracic and abdominal aortic manifestations. (ctsnet.org)
  • Aortic disease or an injury may also cause an aneurysm. (carolineghetes.com)
  • In this report, we present the treatment of a patient with descending thoracic aortic aneurysm and aortic arch aneurysm together with aortoiliac occlusive disease. (thefreedictionary.com)
  • We investigated the possible relation between thoracic aortic disease events and long-term survival in patients after open Abdominal Aortic Aneurysm (AAA) repair, as well as factors associated with event occurrence. (omicsonline.org)
  • We are very pleased with the results from this important study which further supports the movement toward minimally invasive management of aortic disease," said Edward B. Diethrich, M.D., medical director, founder of the Arizona Heart Institute and study author. (bio-medicine.org)
  • Understanding and unraveling the pathophysiology of thoracic aortic aneurysm (TAA), a vascular disease with a potentially high-mortality rate, is one of the next frontiers in vascular biology. (frontiersin.org)
  • Genome-wide linkage analysis of two large unrelated families with thoracic aortic disease followed by whole-exome sequencing of affected relatives identified causative mutations in TGFB2. (nih.gov)
  • Sanger sequencing of 276 probands from families with inherited thoracic aortic disease identified 2 additional TGFB2 mutations. (nih.gov)
  • Acquired factors include age, smoking, hypertension, and history of other aortic or peripheral aneurysms. (sapbc.net)
  • CardioMEMS' technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure, aneurysms and hypertension. (biospace.com)
  • The prevalence of thoracic aortic aneurysm is up to 4.2% of the general population without hypertension. (cancertherapyadvisor.com)
  • We report the case of an 88 year-old male, heavy smoker with arterial hypertension, who had been operated on for abdominal aneurysm five years before, whose unique symptom was scant haemoptysis and radiologically presented a cavity mass in the upper left lobe. (minervamedica.it)
  • Other risk factors for aneurysms include connective tissue disorders, prolonged hypertension, and trauma (usually falls or car accidents). (veins1.com)
  • Hypertension (high blood pressure) damages the blood vessels and increases the chances of developing an aneurysm. (epainassist.com)
  • A fusiform (or true) aneurysm has a uniform shape with a symmetrical dilatation that involves the entire circumference of the aortic wall. (medscape.com)
  • The combination of aortic root dilatation and ascending aneurysm is termed "annuloaortic ectasia. (medscape.com)
  • The aortic valve (not shown) revealed minimal root dilatation. (medscape.com)
  • A transthoracic echocardiogram demonstrates dilatation of the aortic root of 6.2 cm. (kevinmd.com)
  • combined homogenization and the CMT to simulate the dilatation of abdominal aortic aneurysms. (frontiersin.org)
  • When such aneurysms involve the aortic root, the anatomy is often referred to as annuloaortic ectasia. (ahajournals.org)
  • Complications after aneurysm stenting include damage to the blood vessels supplying the leg, which may require another operation. (medlineplus.gov)
  • These last assume the role of the catalytic and accelerator drivers in the onset and progression of pathological complications, including the first and more common, the sporadic thoracic ascending aneurysm (S-TAA) [19]. (thefreelibrary.com)
  • Compression of the trachea, bronchi, and pulmonary arteries are complications in patients with large thoracic aortic aneurysms. (springer.com)
  • Thoracic aortic aneurysm is defined as a cross-sectional diameter exceeding the following cutoff: 4.5 cm in the United States 4.0 cm in South Korea A diameter of 3.5 cm is generally considered dilated. (wikipedia.org)
  • This patient's echocardiogram demonstrates a thoracic aortic aneurysm with an aortic root diameter of 6.2 cm, which requires urgent repair. (kevinmd.com)
  • When a portion of it stretches and swells to more than 50 percent of the original diameter, this is called an aneurysm. (ucdavis.edu)
  • Patients with ascending aortic aneurysm with a diameter of 4.5 cm - 4.9 cm will be observed with serial CT, and will be considered for enrollment into the trial once the aneurysm reaches 5.0 cm. (centerwatch.com)
  • A thoracic aortic diameter ≥ 50% larger than normal is considered an aneurysm (normal diameter varies by location). (merckmanuals.com)
  • CT scanning revealed a large descending thoracic aortic aneurysm measuring 8 cm in maximum diameter (Fig 2). (thefreedictionary.com)
  • Multivariate analysis showed that the risk of thoracic aortic events was increased by a high hemoglobin level, a high Fibrinogen Degradation Product (FDP) level, and a larger AAA diameter. (omicsonline.org)
  • The only factors significantly associated with thoracic aortic events were an AAA diameter of ≥ 55 mm and a high FDP level. (omicsonline.org)
  • The protein expression level of OPN was positively correlated with aortic diameter(r=0.737, P0.01). (cnki.com.cn)
  • Aneurysms tend to grow slowly over time: for abdominal aortic aneurysms, about 10% of their diameter per year, for thoracic aneurysms, maybe slightly less. (healthtap.com)
  • The thoracic aorta's diameter normally ranges from 1 to 1.5 inches. (marketwired.com)
  • Descending thoracic aortic aneurysm repair: 12-year experience using distal aortic perfusion and cerebrospinal fluid drainage. (thefreedictionary.com)
  • Data have indicated that many thoracic aortic aneurysms in people younger than 50 are due to mutations in the genes. (nih.gov)
  • Proinflammatory genes such as TNF-alpha, MCP1 and IL6 were highly expressed in the aneurysm. (ahajournals.org)
  • These results suggest that βarr2 contributes to TAA formation in MFS by regulating ERK1/2-dependent expression of proaneurysmal genes and proteins downstream of the AT 1a R. Importantly, this demonstration of the unique signaling mechanism by which βarr2 contributes to aneurysm formation identifies multiple novel, potential therapeutic targets in MFS. (physiology.org)
  • Loss-of-function mutations in genes encoding contractile proteins have been observed in thoracic aortic aneurysms (TAA). (jci.org)
  • Two groups (Boileau et al, Lindsay et al) sought to identify additional genes responsible for familial thoracic aortic aneurysms. (ahajournals.org)
  • Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes. (semanticscholar.org)
  • Cystic medial degeneration is also seen in patients with ascending thoracic aortic aneurysms who do not have overt connective-tissue disorders. (ahajournals.org)
  • Moreover, it is now recognized that although cases of thoracic aortic aneurysms in the absence of overt connective-tissue disorders may be sporadic, they are often familial and are now referred to as the familial thoracic aortic aneurysm syndrome. (ahajournals.org)
  • The shape of an aortic aneurysm is either saccular or fusiform. (medscape.com)
  • A saccular aneurysm is a localized outpouching of the aortic wall, and it is the shape of a pseudoaneurysm. (medscape.com)
  • The shape of an aneurysm is described as being fusiform or saccular which helps to identify a true aneurysm. (nyhq.org)
  • A saccular-shaped aneurysm bulges or balloons out only on one side. (nyhq.org)
  • CT arterial phase study confirms a saccular thoracic aneurysm with a calcified rim. (radiopaedia.org)
  • From 2006 to 2016, the NHLBI and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) co-funded the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). (nih.gov)
  • Our team provides coordinated evaluations and treatment of aortic diseases, including the most complex aortic aneurysm repair. (uhhospitals.org)
  • The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). (clinicaltrials.gov)
  • Experts at the University of Chicago Medicine Center for Aortic Diseases specialize in identifying the location and severity of your aneurysm. (uchicagomedicine.org)
  • Given the lack of a validated pharmacological therapy for any form of aortic aneurysm, there is a pressing need to determine whether the consistent findings on the role of the RAS in animal models are translatable to humans afflicted with these diseases. (clinsci.org)
  • The Barnes-Jewish & Washington University Heart & Vascular Center offers specialized care for patients with thoracic aortic diseases. (barnesjewish.org)
  • We continue to forge the way, discovering new innovative and improved treatment options for aortic diseases. (umcvc.org)
  • Through patient participation and research, we are helping to advance the best treatment options for all types of aortic diseases. (umcvc.org)
  • Ultimately the use of the technology may be expanded to manage a variety of challenging aortic diseases with less risk, offering new hope for improved results over current treatment of these aneurysms. (veins1.com)
  • Familial thoracic aortic aneurysm is an autosomal dominant disorder of large arteries. (wikipedia.org)
  • The most common cause of a thoracic aortic aneurysm is hardening of the arteries . (medlineplus.gov)
  • The major cause of thoracic aortic aneurysms is a hardening of the arteries, a condition in which fatty deposits adhere to the walls of the arteries, which become less elastic and weaker as a result. (innovations-report.com)
  • This showed severe aortic regurgitation and stenosis in both the left anterior descending and the right coronary arteries. (bmj.com)
  • Purpose: To propose a new simplified technique to occlude multiple segmental arteries for staging and preconditioning of the spinal cord to decrease the potential for spinal cord ischemia after thoracic and thoracoabdominal aortic aneurysm repair. (lu.se)
  • What causes aneurysms? (hopkinsmedicine.org)
  • Chronic exposure to microplastic fibers causes aneurysms, erosion of surface layers and other serious damage to fish gills, and increases egg production in female fish, a sign that chemicals in the fibers may be acting as endocrine disruptors, a new study by researchers at Duke University and China's Zhejiang University of Technology finds. (brightsurf.com)
  • The size cut off for aortic aneurysm is crucial to its treatment. (wikipedia.org)
  • The treatment depends on the location of the aneurysm. (medlineplus.gov)
  • Acher CW, Wynn M. Thoracic and thoracoabdominal aneurysms: open surgical treatment. (medlineplus.gov)
  • Singh MJ, Makaroun MS. Thoracic and thoracoabdominal aneurysms: endovascular treatment. (medlineplus.gov)
  • The development of treatment modalities for thoracic aneurysms followed successful treatment of abdominal aortic aneurysms. (medscape.com)
  • The goal of treatment is to prevent your aneurysm from growing, and intervening before it dissects or ruptures. (mayoclinic.org)
  • Minimally invasive thoracic aortic treatment options include endovascular thoracic aortic repairs using stent grafts and aortic root reconstructions that preserve the aortic valve. (upmc.com)
  • Aneurysm treatment depends on its size and location and your overall health. (upmc.com)
  • A ruptured aneurysm, which requires emergency treatment, can lead to severe pain, internal bleeding, a sudden drop in blood pressure and, if not treated quickly, death. (ucdavis.edu)
  • The etiology, natural history, and treatment of thoracic aneurysms differ for each of these segments. (ahajournals.org)
  • What are the tests to determine treatment for aneurysms? (hopkinsmedicine.org)
  • When the aneurysm is small, careful monitoring may be the only treatment is necessary. (cooperhealth.org)
  • There is no medical treatment of thoracic aortic aneurysms. (sapbc.net)
  • What is a treatment for an aneurysm near the heart? (reference.com)
  • Endovascular treatment of aortic aneurysms has been a common practice for the past 10 years in the United States, Europe and Asia. (innovations-report.com)
  • Current endovascular treatments are marketed worldwide for the treatment of abdominal aortic aneurysms. (innovations-report.com)
  • The location of an aneurysm is distinctly connected with the cause, course, and treatment of a thoracic aneurysm. (nyhq.org)
  • Dignity Health provides lifesaving treatment for ruptured thoracic aortic aneurysm in Arizona. (dignityhealth.org)
  • They tailor treatment to your specific thoracic aneurysm. (uchicagomedicine.org)
  • After more than 500 cases performed at the Arizona Heart Institute, complication rates, including death, compare favorably with open surgical repair, suggesting that endoluminal grafting is a favorable alternative in the treatment of thoracic aortic pathologies," said Ramaiah. (bio-medicine.org)
  • The American College of Cardiology and the American Heart Association has published guidelines on the treatment and management of thoracic aortic aneurysms. (cancertherapyadvisor.com)
  • Tremendous progress has been made in recent years in the treatment of aortic aneurysms. (barnesjewish.org)
  • Some small aneurysms do not require surgical repair but may require treatment with medications to lower blood pressure. (barnesjewish.org)
  • As a physician, I find that the Relay device makes it easier for me to offer this life-saving treatment to a broader population of patients suffering from thoracic aortic aneurysm. (physiciansweekly.com)
  • Not all patients with ascending and arch aneurysms require immediate surgical treatment. (umcvc.org)
  • To make an appointment to discuss your need for aortic treatment, call the University of Michigan Frankel Cardiovascular Center toll-free at 888-287-1082 or email us at [email protected] . (umcvc.org)
  • Treatment depends on the size and growth rate of the thoracic aortic aneurysm. (epainassist.com)
  • You'll die if your aneurysm bursts and you don't get treatment. (msdmanuals.com)
  • The aortic valve is repaired while preserving the valve's integrity, avoiding the need for a valve replacement with a prosthetic valve. (uchicagomedicine.org)
  • The aortic root and valve is replaced with a bio-prosthetic valved conduit. (uchicagomedicine.org)
  • He had received an operation of aortic valve replacement at the age of 16 years. (springer.com)
  • A Doppler echocardiogram showed a trans-aortic valve pressure gradient of 18 mmHg. (springer.com)
  • Thoracic aneurysms do not occur as often as abdominal aneurysms. (nyhq.org)
  • A traditional or minimally invasive technique used to correct thoracic and abdominal aneurysms. (uchicagomedicine.org)
  • Approximately 10 percent of patients may have other family members who have aortic aneurysms. (wikipedia.org)
  • Patients with aortitis and aneurysms present at middle age or older, including advanced ages, especially in the case of giant cell aortitis. (medscape.com)
  • and the remaining 51% had idiopathic noninflammatory aneurysms, with approximately 60% of this last group of patients being hypertensive. (medscape.com)
  • For example, surgeons treating patients with Marfan's Syndrome may choose to repair smaller aneurysms. (ucdavis.edu)
  • In an analysis of their large database of thoracic aortic aneurysm patients, Coady and colleagues 3 found that at least 19% of patients had a family history of a thoracic aortic aneurysm, and they presented at significantly younger ages than did those with sporadic aneurysms. (ahajournals.org)
  • Patients with descending thoracic aneurysm and thoraco-abdominal aneurysm are probably the highest-risk group of patients with aneurysms," Dr. Raissi said. (innovations-report.com)
  • Associated supraaortic trunks lesions were present in 15 patients (45%) and were treated in 12 patients, including 8 in first-stage procedures prior to thoracoabdominal aortic aneurysm repair. (biomedsearch.com)
  • The STARZ-TX2 trial is groundbreaking and excellent news for patients diagnosed with descending thoracic aortic aneurysms," says Dr. Fairman. (innovations-report.com)
  • The cohort consists of patients with conditions related to genetically-induced thoracic aortic aneurysms. (clinicaltrials.gov)
  • All patients referred electively to a participating investigator for the evaluation of their ascending aortic aneurysm will be screened for study eligibility. (centerwatch.com)
  • Those patients that are suitable for the trial based on inclusion and exclusion criteria will then be randomized en-site through a computer-generated randomization program. (centerwatch.com)
  • Survival rates at 5 and 10 years were 87% and 53%, respectively, in patients with a thoracic aortic event and 74% and 56% in those without an event (P=.7). (omicsonline.org)
  • To date, this is the largest published series of patients treated with thoracic ELGs for a variety of thoracic aortic pathologies. (bio-medicine.org)
  • Family history (10% of patients with thoracic aneurysm have other family members with aortic aneurysm. (cancertherapyadvisor.com)
  • Endovascular repair may be helpful in treating high-risk patients who cannot be treated with open aneurysm repair. (barnesjewish.org)
  • For instance, with high-risk patients with arch aneurysms, we offer a less invasive debranching option that bypasses arch vessels and eliminates the need for hypothermic circulatory arrest. (umcvc.org)
  • Thoracic aortic aneurysms occur far less frequently than abdominal aortic aneurysms. (sapbc.net)
  • Thoracic aortic aneurysms occur in 3 to 4% of persons older than 65 years. (cancertherapyadvisor.com)
  • Pseudoaneurysm denotes a ruptured aortic wall with healing of the extravasated blood and formation of the aneurysm wall by fibrous tissue. (medscape.com)
  • This is a rare cause of ascending thoracic aortic aneurysm. (nyhq.org)
  • It is important to recognize and treat thoracic aortic aneurysm before a life-threatening complication occurs. (barnesjewish.org)
  • Haemoptysis caused by thoracic aortic aneurysm is rare and, normally, when it occurs, it is due to an aorto-bronchopulmonary fistula. (minervamedica.it)
  • Ten years experience of thoracic and thoracoabdominal aortic aneurysm surgical repair: lessons learn. (biomedsearch.com)
  • Such infections may not be the common cause of thoracic aortic aneurysm, but it increases the chances for thoracic aortic aneurysm, especially infections such as syphilis or salmonella. (epainassist.com)
  • An aneurysm is a localized dilation or a bulge in the blood vessel due to weakening of the vessel wall. (epainassist.com)
  • [ 3 ] Ascending aortic replacement required the development of cardiopulmonary bypass and was first performed in 1956 by Cooley and DeBakey. (medscape.com)
  • Such Dacron grafts are used to replace ascending, arch, thoracic, and thoracoabdominal aortic segments. (medscape.com)
  • Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters. (nih.gov)
  • Ascending thoracic aortic aneurysm (ATAA) has been associated with diminished biomechanical strength and disruption in the collagen fiber microarchitecture. (nih.gov)
  • The result of this trial will provide evidence based guidance in the appropriate management of ascending aortic aneurysm based on the size criteria, and establish a large database for future investigations. (centerwatch.com)
  • At 10 weeks of age, no differences were detected in the dimensions of the ascending aortic lumen by high frequency ultrasound, despite substantial changes in the aortic tissue of transgenic mice at this age. (ahajournals.org)
  • The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. (harvard.edu)
  • Should I get a yearly CT angiography or an MRA for ascending thoracic aortic aneurysm? (healthtap.com)