Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Aneurysm: Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Aneurysm, Infected: Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Iliac Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.Heart Aneurysm: A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Embolization, Therapeutic: A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Coronary Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.Aortitis: Inflammation of the wall of the AORTA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Endoleak: Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Surgical Procedures, Elective: Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Polyethylene Terephthalates: Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Angiography: Radiography of blood vessels after injection of a contrast medium.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Prosthesis Failure: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.Surgical Instruments: Hand-held tools or implements used by health professionals for the performance of surgical tasks.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Aneurysm, Ruptured: The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Vascular Fistula: An abnormal passage between two or more BLOOD VESSELS, between ARTERIES; VEINS; or between an artery and a vein.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Aortic Diseases: Pathological processes involving any part of the AORTA.ElastinForeign-Body Migration: Migration of a foreign body from its original location to some other location in the body.Mesenteric Artery, Inferior: The artery supplying nearly all the left half of the transverse colon, the whole of the descending colon, the sigmoid colon, and the greater part of the rectum. It is smaller than the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) and arises from the aorta above its bifurcation into the common iliac arteries.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.Esophageal Fistula: Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.Celiac Artery: The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.Aorta: The main trunk of the systemic arteries.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Mesenteric Artery, Superior: A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Radiography, Interventional: Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.Matrix Metalloproteinase 9: An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.Hospital Mortality: A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.Balloon Occlusion: Use of a balloon CATHETER to block the flow of blood through an artery or vein.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Paraparesis: Mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Length of Stay: The period of confinement of a patient to a hospital or other health facility.Buttocks: Either of two fleshy protuberances at the lower posterior section of the trunk or HIP in humans and primate on which a person or animal sits, consisting of gluteal MUSCLES and fat.Intraoperative Complications: Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.Tomography, Spiral Computed: Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.Intestinal Fistula: An abnormal anatomical passage between the INTESTINE, and another segment of the intestine or other organs. External intestinal fistula is connected to the SKIN (enterocutaneous fistula). Internal intestinal fistula can be connected to a number of organs, such as STOMACH (gastrocolic fistula), the BILIARY TRACT (cholecystoduodenal fistula), or the URINARY BLADDER of the URINARY TRACT (colovesical fistula). Risk factors include inflammatory processes, cancer, radiation treatment, and surgical misadventures (MEDICAL ERRORS).Elastic Tissue: Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.Constriction: The act of constricting.Anterior Cerebral Artery: Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.Databases as Topic: Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)Arteriovenous Fistula: An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Incidental Findings: Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.Surgical Procedures, Minimally Invasive: Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.Suture Techniques: Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).Neurosurgical Procedures: Surgery performed on the nervous system or its parts.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Laparotomy: Incision into the side of the abdomen between the ribs and pelvis.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Equipment Design: Methods of creating machines and devices.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Calcium Chloride: A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.Platinum: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Loeys-Dietz Syndrome: An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.Replantation: Restoration of an organ or other structure to its original site.Retroperitoneal Fibrosis: A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.Retreatment: The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Emergency Treatment: First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.Subclavian Artery: Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.Splenic Artery: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.Transducers, Pressure: Transducers that are activated by pressure changes, e.g., blood pressure.Duodenal Diseases: Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Preoperative Care: Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Axillary Artery: The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.Sinus of Valsalva: The dilatation of the aortic wall behind each of the cusps of the aortic valve.Doxycycline: A synthetic tetracycline derivative with similar antimicrobial activity.Vascular Grafting: Surgical insertion of BLOOD VESSEL PROSTHESES, or transplanted BLOOD VESSELS, or other biological material to repair injured or diseased blood vessels.Blood Loss, Surgical: Loss of blood during a surgical procedure.Viscera: Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.Vertebral Artery: The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Radiographic Image Interpretation, Computer-Assisted: Computer systems or networks designed to provide radiographic interpretive information.Finite Element Analysis: A computer based method of simulating or analyzing the behavior of structures or components.Cerebral Arteries: The arterial blood vessels supplying the CEREBRUM.Retroperitoneal Space: An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.Ligation: Application of a ligature to tie a vessel or strangulate a part.Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Cardiovascular Surgical Procedures: Surgery performed on the heart or blood vessels.Fistula: Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Device Removal: Removal of an implanted therapeutic or prosthetic device.Specialties, Surgical: Various branches of surgical practice limited to specialized areas.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Recurrence: The return of a sign, symptom, or disease after a remission.Posterior Cerebral Artery: Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.Popliteal Artery: The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.Ultrasonography, Doppler, Duplex: Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.Catheterization, Peripheral: Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.Syphilis, Cardiovascular: Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Intraoperative Care: Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Graft Occlusion, Vascular: Obstruction of flow in biological or prosthetic vascular grafts.Angioscopy: Endoscopic examination, therapy or surgery performed on the interior of blood vessels.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Circle of Willis: A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.Craniotomy: Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)Microsurgery: The performance of surgical procedures with the aid of a microscope.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Heart Bypass, Left: Diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Equipment Safety: Freedom of equipment from actual or potential hazards.Tuberculosis, Cardiovascular: Pathological conditions of the CARDIOVASCULAR SYSTEM caused by infection of MYCOBACTERIUM TUBERCULOSIS. Tuberculosis involvement may include the HEART; the BLOOD VESSELS; or the PERICARDIUM.Alloys: A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Hospital Costs: The expenses incurred by a hospital in providing care. The hospital costs attributed to a particular patient care episode include the direct costs plus an appropriate proportion of the overhead for administration, personnel, building maintenance, equipment, etc. Hospital costs are one of the factors which determine HOSPITAL CHARGES (the price the hospital sets for its services).Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Brachiocephalic Trunk: The first and largest artery branching from the aortic arch. It distributes blood to the right side of the head and neck and to the right arm.Cerebral Revascularization: Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.Drainage: The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.Matrix Metalloproteinase 12: A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Thoracotomy: Surgical incision into the chest wall.Prosthesis-Related Infections: Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).Colitis, Ischemic: Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.Models, Anatomic: Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Systemic Inflammatory Response Syndrome: A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.Vertebral Artery Dissection: Splitting of the vessel wall in the VERTEBRAL ARTERY. Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the vertebral artery, aneurysm formation, or THROMBOEMBOLISM. Vertebral artery dissection is often associated with TRAUMA and injuries to the head-neck region but can occur spontaneously.Postoperative Period: The period following a surgical operation.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Carotid Artery, Internal, Dissection: The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Postoperative Hemorrhage: Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Mechanical Thrombolysis: Procedures to cause the disintegration of THROMBI by physical interventions.Peripheral Vascular Diseases: Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Equipment Failure Analysis: The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.Psoas Abscess: Abscess of the PSOAS MUSCLES resulting usually from disease of the lumbar vertebrae, with the pus descending into the muscle sheath. The infection is most commonly tuberculous or staphylococcal.Myocytes, Smooth Muscle: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).Hematoma: A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.

Serum triglyceride: a possible risk factor for ruptured abdominal aortic aneurysm. (1/3079)

BACKGROUND: We aimed to determine the relationship between ruptured abdominal aortic aneurysm (AAA) and serum concentrations of lipids and apolipoproteins. METHODS: A cohort of 21 520 men, aged 35-64 years, was recruited from men attending the British United Provident Association (BUPA) clinic in London for a routine medical examination in 1975-1982. Smoking habits, weight, height and blood pressure were recorded at entry. Lipids and apolipoproteins were measured in stored serum samples from the 30 men who subsequently died of ruptured AAA and 150 matched controls. RESULTS: Triglyceride was strongly related to risk of ruptured AAA. In univariate analyses the risk in men on the 90th centile of the distribution relative to the risk in men on the 10th (RO10-90) was 12 (95% confidence interval [CI] : 3.8-37) for triglyceride, 5.5 (95% CI: 1.8-17) for apolipoprotein B (apoB) (the protein component of low density lipoprotein [LDL]), 0.15 (95% CI : 0.04-0.56) for apo A1 (the protein component of high density lipoprotein [HDL]), 3.7 (95% CI: 1.4-9.4) for body mass index and 3.0 (95% CI: 1.1-8.5) for systolic blood pressure. Lipoprotein (a) (Lp(a)) was not a significant risk factor (RO10-90 = 1.6, 95% CI: 0.6-3.0). In multivariate analysis triglyceride retained its strong association. CONCLUSION: Triglyceride appears to be a strong risk factor for ruptured AAA, although further studies are required to clarify this. If this and other associations are cause and effect, then changing the distribution of risk factors in the population (by many people stopping smoking and adopting a lower saturated fat diet and by lowering blood pressure) could achieve an important reduction in mortality from ruptured AAA.  (+info)

Ruptured abdominal aortic aneurysms: selecting patients for surgery. (2/3079)

OBJECTIVES: Mortality from ruptured abdominal aortic aneurysm (RAAA) remains high. Despite this, withholding surgery on poor-prognosis patients with RAAA may create a difficult dilemma for the surgeon. Hardman et al. identified five independent, preoperative risk factors associated with mortality and proposed a model for preoperative patient selection. The aim of this study was to test the validity of the same model in an independent series of RAAA patients. METHODS: A consecutive series of patients undergoing surgery for RAAA was analysed retrospectively by case-note review. Thirty-day operative mortality and the presence of the five risk factors: age (> 76 years), creatinine (Cr) (> 190 mumol/l), haemoglobin (Hb) (< 9 g/dl), loss of consciousness and electrocardiographic (ECG) evidence of ischaemia were recorded for each patient. RESULTS: Complete data sets existed for 69 patients (mean age: 73 years, range: 38-86 years, male to female ratio: 6:1). Operative mortality was 43%. The cumulative effect of 0, 1 and 2 risk factors on mortality was 18%, 28% and 48%, respectively. All patients with three or more risk factors died (eight patients). CONCLUSIONS: These results lend support to the validity of the model. The potential to avoid surgery in patients with little or no chance of survival would spare unnecessary suffering, reduce operative mortality and enhance use of scarce resources.  (+info)

Incisional hernias in patients with aortic aneurysmal disease: the importance of suture technique. (3/3079)

OBJECTIVE: To study the rate of incisional hernia at 12 months in patients undergoing abdominal aortic aneurysm repair compared with others undergoing other surgery through midline incisions. METHODS: A prospective study of 1023 patients, 85 of these with aneurysmal disease. Wounds were continuously closed and the suture technique was monitored by the suture length to wound length ratio. RESULTS: Wound incisions were longer and operations lasted longer in aneurysm patients than in others. Incisional hernia was less common if closure was with a suture length to wound length ratio of at least four. Wounds were closed with a ratio of four or more in 39% (33 of 85) of aneurysm patients and in 59% (546 of 923) of others (p < 0.01). In aneurysm patients no wound dehiscence was recorded, the rate of wound infection was low and incisional hernia occurred in the same amount as in others. CONCLUSIONS: It is concluded that the rate of incisional hernia is similar in patients with abdominal aortic aneurysmal disease and others. Wounds are closed with a less meticulous suture technique in aneurysm patients.  (+info)

Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)? (4/3079)

OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to that in the general population (6.8% and 4.7%, respectively, p > 0.3). The frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, aneurysmal stiffness, and presence of factors that may be associated with AAA (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA and patients in whom the two disorders coexisted did not appear to have different clinical characteristics except for the lower occurrence of ischaemic heart disease among the PiZ-carriers.  (+info)

Repair of ruptured thoracoabdominal aortic aneurysm is worthwhile in selected cases. (5/3079)

INTRODUCTION: The risks and benefits of operating on patients with ruptured thoracoabdominal aortic aneurysm (TAAA) have not been defined. The aim of the present study is to report this unit's experience with operations performed for ruptured TAAA over a 10-year period. METHODS: Interrogation of a prospectively gathered computerised database. PATIENTS: Between 1 January 1983 and 30 June 1996, 188 consecutive patients with TAAA were operated on, of whom 23 (12%) were operated for rupture. RESULTS: There were nine survivors (40%). Patients whose preoperative systolic blood pressure remained above 100 mmHg were significantly more likely to survive (4/8 vs. 13/15, p = 0.03 by Fisher's exact test). Survival was also related to Crawford type: type I (two of three survived); II (none of six); III (two of six); and IV (five of eight). All non-type II, non-shocked patients survived operation. Survivors spent a median of 28 (range 10-66) postoperative days in hospital, of which a median of 6 (range 2-24) days were spent in the intensive care unit. Survivor morbidity comprised prolonged ventilation (> 5 days) (n = 3); tracheostomy (n = 1); and temporary haemofiltration (n = 2). No survivor developed paraplegia or required permanent dialysis. CONCLUSIONS: Patients in shock with a Crawford type II aneurysm have such a poor prognosis that intervention has to be questioned except in the most favourable of circumstances. However, patients with types I, III and IV who are not shocked on presentation can be salvaged and, where possible, should be transferred to a unit where appropriate expertise and facilities are available.  (+info)

The value of late computed tomographic scanning in identification of vascular abnormalities after abdominal aortic aneurysm repair. (6/3079)

PURPOSE: The purpose of this study was to determine the prevalence of late arterial abnormalities after aortic aneurysm repair and thus to suggest a routine for postoperative radiologic follow-up examination and to establish reference criteria for endovascular repair. METHODS: Computed tomographic (CT) scan follow-up examination was obtained at 8 to 9 years after abdominal aortic aneurysm (AAA) repair on a cohort of patients enrolled in the Canadian Aneurysm Study. The original registry consisted of 680 patients who underwent repair of nonruptured AAA. When the request for CT scan follow-up examination was sent in 1994, 251 patients were alive and potentially available for CT scan follow-up examination and 94 patients agreed to undergo abdominal and thoracic CT scanning procedures. Each scan was interpreted independently by two vascular radiologists. RESULTS: For analysis, the aorta was divided into five defined segments and an aneurysm was defined as a more than 50% enlargement from the expected normal value as defined in the reporting standards for aneurysms. With this strict definition, 64.9% of patients had aneurysmal dilatation and the abnormality was considered as a possible indication for surgical repair in 13.8%. Of the 39 patients who underwent initial repair with a tube graft, 12 (30.8%) were found to have an iliac aneurysm and six of these aneurysms (15.4%) were of possible surgical significance. Graft dilatation was observed from the time of operation (median graft size of 18 mm) to a median size of 22 mm as measured by means of CT scanning at follow-up examination. Fluid or thrombus was seen around the graft in 28% of the cases, and bowel was believed to be intimately associated with the graft in 7%. CONCLUSION: Late follow-up CT scans after AAA repair often show vascular abnormalities. Most of these abnormalities are not clinically significant, but, in 13.8% of patients, the thoracic or abdominal aortic segment was aneurysmal and, in 15.4% of patients who underwent tube graft placement, one of the iliac arteries was significantly abnormal to warrant consideration for surgical repair. On the basis of these findings, a routine CT follow-up examination after 5 years is recommended. This study provides a population-based study for comparison with the results of endovascular repair.  (+info)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (7/3079)

BACKGROUND: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. METHODS: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (DeltaAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. RESULTS: AAAs developed in all vehicle-treated rats, with a mean AD (+/- SE) that increased from 1.60 +/- 0.03 mm before perfusion to 5.98 +/- 1.02 mm on day 14 (DeltaAD = 276.4 +/- 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 +/- 0.05 mm to 3.59 +/- 0.34 mm (DeltaAD = 128.1 +/- 18.7%; P <.05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 +/- 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 +/- 87.8 pmol/sample to 176.7 +/- 33.4 pmol/sample; P <.05) but only by 65.6% in the animals treated with RS 312908 (416.2 +/- 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. CONCLUSIONS: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs.  (+info)

Infrarenal endoluminal bifurcated stent graft infected with Listeria monocytogenes. (8/3079)

Prosthetic graft infection as a result of Listeria monocytogenes is an extremely rare event that recently occurred in a 77-year-old man who underwent endoluminal stent grafting for infrarenal abdominal aortic aneurysm. The infected aortic endoluminal prosthesis was removed by means of en bloc resection of the aneurysm and contained endograft with in situ aortoiliac reconstruction. At the 10-month follow-up examination, the patient was well and had no signs of infection.  (+info)

TY - JOUR. T1 - A novel use of ultrasound in pulseless electrical activity. T2 - The diagnosis of an acute abdominal aortic aneurysm rupture. AU - Hendrickson, Robert G.. AU - Dean, Anthony J.. AU - Costantino, Thomas G.. PY - 2001/8/20. Y1 - 2001/8/20. N2 - We report a case of a patient who presented to the Emergency Department with pulseless electrical activity. A rapid diagnosis of ruptured abdominal aortic aneurysm was made by Emergency Medicine bedside ultrasonography. On arrival, the patient was without palpable pulses and bradycardic. Therapy with epinephrine, fluids, and atropine was initiated. A bedside ultrasound was immediately performed and revealed coordinated cardiac motion with empty ventricles. A rapid search for signs of blood loss in the abdomen revealed a large abdominal aortic aneurysm. Pulses were restored with fluid, blood, and epinephrine and surgical intervention was begun within 30 min of patient arrival.. AB - We report a case of a patient who presented to the Emergency ...
We describe the case of a man who died of an abdominal aortic aneurysm rupture after an intravitreal injection of bevacizumab for neovascular age-related macular degeneration. A 74-year-old Korean man presented with visual disturbance in his right eye. He had previously been diagnosed with diabetes and hypertension, which were controlled with oral medications. We diagnosed him with neovascular age-related macular degeneration and he was treated by monthly intravitreal injection of bevacizumab for three months. Four days after his third intravitreal bevacizumab injection, he died of an abdominal aortic aneurysm rupture and uncontrolled bleeding. Abdominal aortic aneurysm rupture is highly lethal and there is a possible correlation with intravitreal injection of bevacizumab. Thus, we need to consider the risks of intravitreal bevacizumab injections for patients with abdominal aortic aneurysms.
Endovascular Abdominal Aortic Aneurysm Repair Devices Report by Material, Application, and Geography Global Forecast to 2021 is a professional and in-depth research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, united Kingdom, Japan, South Korea and China).. Get Sample copy of the Report: http://sacinsight.com/report/global-endovascular-abdominal-aortic-aneurysm-repair-devices-market-research-report-2017_9dimen/. The report firstly introduced the Endovascular Abdominal Aortic Aneurysm Repair Devices basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new ...
Abdominal aortic aneurysm repair has undergone a revolution since Volodos and Parodi described endoluminal repair in the early 1990s. Subsequent data from large registries have confirmed its efficacy. Randomised controlled trials have shown that although endoluminal repair may not be as cost effective as open repair, it can be performed with a lower mortality in patients fit for open repair. Some European countries (eg, Belgium) have taken the results of these trials to rationalise the number of hospitals able to do endovascular repair. The devices continue to improve and although most require open surgical access at present, in future percutaneous access will become the norm. This article reviews the current state of endoluminal aortic aneurysm repair in the infrarenal aorta. ...
About 3 out of 4 abdominal aortic aneurysms dont cause symptoms. An aneurysm may be found by X-ray, computed tomography (CT or CAT) scan, or magnetic resonance imaging (MRI) that was done for other reasons. Since abdominal aneurysm may not have symptoms, its called the "silent killer" because it may rupture before being diagnosed. Pain is the most common symptom of an abdominal aortic aneurysm. The pain associated with an abdominal aortic aneurysm may be located in the abdomen, chest, lower back, or groin area. The pain may be severe or dull. Sudden, severe pain in the back or abdomen may mean the aneurysm is about to rupture. This is a life-threatening medical emergency. Abdominal aortic aneurysms may also cause a pulsing sensation, similar to a heartbeat, in the abdomen. The symptoms of an abdominal aortic aneurysm may look like other medical conditions or problems. Always see your doctor for a diagnosis. ...
ATLANTA--Researchers have found a link between dysregulated tryptophan metabolism and abdominal aortic aneurysm, a life-threatening vascular disease, according to a new study led by Georgia State University.. Abdominal aortic aneurysm is a permanent, localized enlargement of the abdominal aorta, the largest artery in the abdomen that provides blood to the organs and tissues of the abdomen, pelvis and legs. Because the abdominal aorta is one of four sections of the aorta, the bodys main supplier of blood, a ruptured abdominal aortic aneurysm can cause life-threatening bleeding, according to the Mayo Clinic.. Abdominal aortic aneurysm occurs in up to 9 percent of adults older than 65 years of age, with about 15,000 deaths each year in the United States after rupture. Abdominal aortic aneurysms often grow slowly and without symptoms, making them difficult to detect.. There are no proven therapeutic strategies to block progression of the disease and rupture of the abdominal aorta. The only possible ...
Introdução. O updated Glasgow Aneurysm Score (uGAS), projetado para prever a mortalidade/morbilidade perioperatórias após rAAA, revelou ser um bom preditor de resultados a curto prazo após o tratamento com cirurgia convencional (CC) e Endovascular Aneurysm Repair (EVAR). Os objetivos foram caracterizar os doentes operados a Aneurisma da Aorta Abdominal roto (AAAr) e avaliar a aplicabilidade do uGAS na população de doentes de uma instituição terciária nacional, com capacidade de rEVAR.. Métodos. Fizemos uma análise retrospetiva dos doentes operados, no nosso serviço, a AAAr entre fevereiro/2011 e fevereiro/2015. As variáveis foram obtidas através da pesquisa numa base de dados de AAAr da instituição e incluíram: idade, sexo, presença de doença cardíaca, doença cerebrovascular, doença renal aguda/crónica e existência de choque pré‐operatório. Foi obtida a mortalidade perioperatória (30 dias ou intra‐hospitalar). O score de risco foi aplicado retrospetivamente e a ...
&ldquo;The Report&nbsp;Abdominal Aortic Aneurysms Global Clinical Trials Review, H1, 2015 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz&rdquo;Abdominal Aortic Aneurysms Global Clinical Trials Review, H1, 2015" provides data on the Abdominal Aortic Aneurysms clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Abdominal Aortic Aneurysms. It...
The last decade has represented a time of fundamental change in the treatment of abdominal aortic aneurysms (AAAs). Potentially, vascular surgeons will either acquire catheter-based skills or relinquish the care for many patients with infrarenal AAA. We investigated AAA referral patterns and method of AAA repair after the establishment of an endovascular AAA program at our institution. We conducted a retrospective review of elective AAA repairs after the initiation of an endovascular AAA program in April 1994. Six vascular surgeons performed all procedures with a clear distinction between the surgeons (n=3) who performed traditional AAA repair only and those (n=3) who managed AAAs by means of either endovascular or traditional treatment. From April 1994 through December 2000, 740 elective AAA repairs were performed. During this time the mean number of AAA repairs has been 106/year ranging from 75 to 155/year. More notable however is the steady increase in the percentage of endovascular AAA ...
Introduction: Smoking cessation is one of the few available strategies to decrease the risk for expansion and rupture of small abdominal aortic aneurysms (AAAs). The cost-effectiveness of an intensive smoking cessation therapy in patients with small AAAs identified at screening was evaluated. Methods: A Markov cohort simulation model was used to compare an 8-week smoking cessation intervention with adjuvant pharmacotherapy and annual revisits vs nonintervention among 65-year-old male smokers with a small AAA identified at screening. The smoking cessation rate was tested in one-way sensitivity analyses in the intervention group (range, 22%-57%) and in the nonintervention group (range, 3%-30%). Literature data on the effect of smoking on AAA expansion and rupture was factored into the model. Results: The intervention was cost-effective in all tested scenarios and sensitivity analyses. The smoking cessation intervention was cost-effective due to a decreased need for AAA repair and decreased rupture ...
An abdominal aortic aneurysm can be dangerous if it isnt spotted early on. It can get bigger over time and could burst causing life-threatening bleeding. The abdominal aortic aneurysm repair surgeries can be performed via open repair or Endovascular Aneurysm Repair. Know the recovery period, complications and survival rate following abdominal aortic aneurysm repair surgery.
The incidence of abdominal aortic aneurysm (AAA) varies among ethnic groups. Wikipedia Risk factors include genetic susceptibility, atherosclerosis, male sex, smoking, and hypertension. If detected before rupture, a dangerously large abdominal aortic aneurysm can usually be surgically repaired. Wikipedia Although of small effect each, SNPs reported to affect risk of abdominal aortic aneurysm and to be reasonably robust statistically include [PMID 24834361 ...
OBJECTIVES: To study bowel ischaemia in transfemorally placed endoluminal grafting (TPEG) for abdominal aortic aneurysms, and any relation to cytokine response or postoperative fever. DESIGN: Prospective not randomised. University hospital setting. MATERIAL: Fourteen cases of conventional surgery and 23 cases of endovascular technique for infrarenal abdominal aortic aneurysm repair. METHODS: Tonometry was used for sigmoid colon pH, and ELISAs for serum IL-6. RESULTS: Mucosal pH in the sigmoid colon fell significantly during clamping and reperfusion in both groups. Lowest measured sigmoid colon pH was 7.10 in the open group, compared to 7.22 in the TPEG group (p , 0.05). The IL-6 levels in serum peaked after 4 h of reperfusion; 249 pg/ml in the open group, compared to 89 pg/ml in the TPEG group (p , 0.05). High levels of IL-6 in the postoperative period and persisting low sigmoidal pH were associated with serious complications. Postoperative temperature did not differ significantly between the ...
OBJECTIVE: The aim of this study was to describe our early experience in the treatment of ruptured abdominal aortic aneurysms with bifurcated endografts. We report on our initial twelve-month experience using this approach. METHODS: Clinical data on patients with ruptured abdominal aortic aneurysms treated at a single tertiary center in Brazil were prospectively recorded. The eligibility for endovascular treatment was evaluated by computed tomography scanning and anatomical features were determined based on the method of treatment. RESULTS: From February 2012 to January 2013 (12 months), 28 consecutive patients (mean age 67.2 years, range 45-85 years) underwent treatment for ruptured abdominal aortic aneurysms at our hospital. Eighteen patients (64.3%) were suitable for and underwent endovascular treatment with bifurcated endografts (16 patients) or aortouniiliac endografts (two patients). Ten patients who were considered unsuitable for endograft repair underwent open repair. Seven patients were ...
This case illustrates an infrarenal abdominal aortic aneurysm rupture. An abdominal aortic aneurism (AAA) is defined as a permanent and irreversible localized dilatation of the abdominal aorta1. AAA rupture has an overall mortality rate of appro...
TY - JOUR. T1 - Intraluminal thrombus is associated with early rupture of abdominal aortic aneurysm. AU - Haller, Stephen J.. AU - Crawford, Jeffrey D.. AU - Courchaine, Katherine M.. AU - Bohannan, Colin J.. AU - Landry, Gregory J.. AU - Moneta, Gregory L.. AU - Azarbal, Amir F.. AU - Rugonyi, Sandra. PY - 2018/4. Y1 - 2018/4. N2 - Background: The implications of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA) are currently unclear. Previous studies have demonstrated that ILT provides a biomechanical advantage by decreasing wall stress, whereas other studies have associated ILT with aortic wall weakening. It is further unclear why some aneurysms rupture at much smaller diameters than others. In this study, we sought to explore the association between ILT and risk of AAA rupture, particularly in small aneurysms. Methods: Patients were retrospectively identified and categorized by maximum aneurysm diameter and rupture status: small (,60 mm) or large (≥60 mm) and ruptured (rAAA) ...
First generation aortic endovascular stent-grafts (EVG) had low applicability and were associated with a significant incidence of peri-procedural complications. With time, a number of EVG systems perished (some predictably) in a "survival of the fittest". Improvements in design have been made as a result of these failures. Current designs have low peri-procedural morbidity and mortality and improving durability. This paper sets out to discuss the use of a variety of EVG for abdominal aortic aneurysm repair. The ideal properties of an EVG will be outlined along with some of the advantages and limitations of current, and, where appropriate, historical, commercially available stent-graft systems.. ...
When trumpeter, Peter Cripps had a CT scan for a kidney stone it was discovered he also had an abdominal aortic aneurysm.. "Just before Christmas I had the most horrendous pain in my abdomen. I had a CT scan, which revealed I had a kidney stone. Thankfully, that was quite small but, more worryingly, the nurse told me I also had an abdominal aortic aneurysm. The surgeon came to see me straight away and recommended an open AAA operation which was done on January 16 2007. "Id had a four-way heart bypass four years earlier and five years before that a heart attack and I was convinced I was not going to make it. But the operation went really well and I was out of hospital a week later. "I felt weak and tired and I was quite insecure when I first got home. But I tried to do a little more each day and was soon back on my feet. In fact, I was able to go back to my part-time job fitting insulation mats on yacht engines within just three weeks. I play trumpet in a band and was able to start blowing again ...
Introduction: Endovascular aneurysm repair (EVAR) has been an established treatment for abdominal aortic aneurysm (AAA). Although statin use has been shown associated with better long-term survival following open AAA surgery, its impact on EVAR has not been systematically explored.. Methods: We retrospectively analyzed a multicenter database of 368 consecutive patients (age, 76 ± 8 years; 84% male) undergoing EVAR for AAA between November 2006 and December 2013. The outcome measure was overall survival following EVAR. Independent predictor associated with the outcome was assessed by Cox proportional hazard regression model. Furthermore, the association between the statin use and the outcome was assessed.. Results: During the follow-up of 30 ± 20 months, 38 patients died from cardiovascular disease (33%), cancer (23%) or infection (23%). Survival rate was 96% and 81% at 1 and 5 years, respectively. In Cox regression analysis, statin use (in 213 AAA patients, 58%) was negatively associated with ...
We thank Dr Han and colleagues, and Dr Murakami and colleagues, as well, for their interest in our study1 and for discussing our proposed pathomechanism of segmental aortic stiffness in the context of experimental and clinical aortic coarctation.. We read with great interest the report of an alternative rabbit model that combines external elastase application with proximal aortic coarctation to model accelerated abdominal aortic aneurysm development.2 Although poststenotic turbulent flow caused by experimental aortic constriction may critically contribute to aortic dilation in this model, aortic coarctation also results in segmental aortic stiffness and may therefore generate substantial axial wall stress during systolic aortic expansion that we believe is a critical driver of early abdominal aortic aneurysm development.. In our study, mild aortic infusion of porcine pancreatic elastase (1.5 U/mL for 5 minutes) was sufficient to induce initial elastin damage and aortic stiffening that eventually ...
TY - JOUR. T1 - Endovascular aortic aneurysm repair with carbon dioxide-guided angiography in patients with renal insufficiency. AU - Criado, Enrique. AU - Upchurch, Gilbert R.. AU - Young, Kate. AU - Rectenwald, John E.. AU - Coleman, Dawn M.. AU - Eliason, Jonathon L.. AU - Escobar, Guillermo A.. PY - 2012/6/1. Y1 - 2012/6/1. N2 - Objective: Renal dysfunction following endovascular abdominal aortic aneurysm repair (EVAR) remains a significant source of morbidity and mortality. We studied the use of carbon dioxide (CO 2) as a non-nephrotoxic contrast agent for EVAR. Methods: Recorded data from 114 consecutive patients who underwent EVAR with CO 2 as the contrast agent over 44 months were retrospectively analyzed. CO 2 was used exclusively in 72 patients and in an additional 42 patients iodinated contrast (IC) was given (mean, 37 mL). Renal and hypogastric artery localization and completion angiography were done with CO 2 in all patients, including additional arterial embolization in 16 cases. ...
An aortic aneurysm is a dilation of a segment of the aorta where the wall of the vessel becomes thin and weak. The most common site involves the abdominal aorta below the arteries to the kidneys. The main risk of an aortic aneurysm is rupture. If the aneurysm ruptures, the chance for survival is very low. If the aneurysm is repaired before rupture, the chance of survival is very good. In general, an abdominal aortic aneurysm should be repaired when it reaches a size of 5 centimeters in diameter. On average, an aortic aneurysm will increase in size 0.5 centimeters per year. A more rapid rate of enlargement might lead us to recommend repair before the aneurysm reaches 5 centimeters. There are currently two acceptable methods used to repair an abdominal aortic aneurysm. The most common method involves making an incision in the abdomen and directly exposing the aneurysm. The involved section of aorta is completely replaced with a prosthetic fabric tube. This operation is highly effective at reducing ...
TY - JOUR. T1 - Comparison of transmitted pressure across percutaneous abdominal aorta aneurysm conduits. T2 - A new in vitro model. AU - Thorpe, P. E.. AU - Hunter, D. W.. AU - Chouinard, P.. AU - Agrawal, Devendra K.. AU - Zhan, X. X.. PY - 1996. Y1 - 1996. N2 - The treatment of abdominal aorta aneurysm is aimed at decreasing pressure on the arterial wall which is thought to cause growth and eventual rupture of the aneurysm. If significant pressure is transmitted across percutaneously placed stem-grafts, they may prove unacceptable for abdominal aorta aneurysm repair. Therefore, we developed an in mm model to study transmission of pressure across various materials implanted in an aneurysmal lumen. A pinch roller model producing pulsatile flow through an aneurysm fashioned from heated polyethylene was used with H2O, glycerol and heparinized bovine blood. Continuous pressure readings obtained from 3 sites (above, below and mid aneurysm) were compared between different materials including bare ...
I write a lot pregnabcy yahoo answers and some abdominal aortic aneurysm after pregnancy the things that young people think will stop them becoming pregnant are incredibly naпve - its scary how uninformed they are. Women need to measure their body temperature every morning, before arising. Read this article to learn why French women are encouraged to give birth and what are the anurysm in giving birth. What I like abdominal aortic aneurysm after pregnancy this calendar is that it shows how the days repeat. However, hair loss during pregnancy is completely normal and is said to occur due to fluctuating hormones in the body. Family history: Women with a aortkc history aorttic ovarian cancer, or breast cancer are aneuryysm prone to the chance of developing ovarian cancer compared to other women. Apparently, Dutch fathers have been in the scene of aneuryzm abdominal aortic aneurysm after pregnancy a long time as can be observed in paintings from the 17th and 18th centuries. Or, evening sickness. ...
Long-term outcome of ruptured abdominal aortic aneurysm: impact of treatment and age Jelle W Raats,1 Hans C Flu,1 Gwan H Ho,1 Eelco J Veen,1 Louwerens D Vos,2 Ewout W Steyerberg,3 Lijckle van der Laan1 1Department of Surgery, Amphia Hospital, Breda, 2Department of Radiology, Amphia Hospital, Breda, 3Department of Public Health, Erasmus MC, Rotterdam, the Netherlands Background: Despite advances in operative repair, ruptured abdominal aortic aneurysm (rAAA) remains associated with high mortality and morbidity rates, especially in elderly patients. The purpose of this study was to evaluate the outcomes of emergency endovascular aneurysm repair (eEVAR), conventional open repair (OPEN), and conservative treatment in elderly patients with rAAA.Methods: We conducted a retrospective study of all rAAA patients treated with OPEN or eEVAR between January 2005 and December 2011 in the vascular surgery department at Amphia Hospital, the Netherlands. The outcome in patients treated for rAAA by eEVAR or OPEN repair
Abdominal aortic aneurysm (AAA) is a potentially fatal disease and survival rate is very low when rupture occurs. Experimental models related with abdominal aortic aneurysm are performed on intact and ruptured aneurysm (RAAA) models. By using AAA models; complex mechanisms of aneurysm formation, aneurysm progression, chance of rupture, preventative and treating methods are researched. Most commonly used methods for creating aneurysm are utilization of transgenic or knockout animals; intra/extraluminal pharmacologic treatments such as elastase, calcium chloride or angiotensin II; hyperlipidemic diet application and surgical interventions such as xenograft, stenosis or graft. Pathogenesis of aneurysm is predominantly examined on rodents whereas studies aimed at development of treatment modalities such as surgical or endovascular interventions are predominantly performed on large animals like rabbit, porcine or dog. Experimental studies modeling aneurysm rupture (RAAA) simulate shock (total hypoperfusion)
Desgranges P, Kobeiter H, Katsahian S, et al. Editors choice - ECAR (endovasculaire ou chirurgie dans les anévrysmes aorto-iliaques rompus): a French randomized controlled trial of endovascular versus open surgical repair of ruptured aorto-iliac aneurysms. Eur J Vasc Endovasc Surg. 2015;50(3):303-310. PMID: 26001320 www.ncbi.nlm.nih.gov/pubmed/26001320.. Glebova NO, Malas MB. The management of ruptured abdominal aortic aneurysm. In: Cameron JL, Cameron AM, eds. Current Surgical Therapy. 11th ed. Philadelphia, PA: Elsevier Saunders; 2014:788-791.. Holt PJE, Thompson MM. Abdominal aortic aneurysm. In: Cronenwett JL, Johnston KW, eds. Rutherfords Vascular Surgery. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 130. ...
The pathology of the human abdominal aortic aneurysm (AAA) and its relationship to the later complication of intraluminal thrombus (ILT) formation remains unclear. The hemodynamics in the diseased abdominal aorta are hypothesized to be a key contributor to the formation and growth of ILT. The objective of this investigation is to establish a reliable 3D flow visualization method with corresponding validation tests with high confidence in order to provide insight into the basic hemodynamic features for a better understanding of hemodynamics in AAA pathology and seek potential treatment for AAA diseases. A stereoscopic particle image velocity (PIV) experiment was conducted using transparent patient-specific experimental AAA models (with and without ILT) at three axial planes. Results show that before ILT formation, a 3D vortex was generated in the AAA phantom. This geometry-related vortex was not observed after the formation of ILT, indicating its possible role in the subsequent appearance of ILT ...
Are you looking for information on Abdominal Aortic Aneurysm? Find articles, reviews, products and resources related to Abdominal Aortic Aneurysm
A new landmark study by researchers at the University of Maryland School of Medicine (UMSOM) found that patients with a vascular condition, called abdominal aortic aneurysm, received no benefits from taking a common antibiotic drug to reduce inflammation. Patients who took the antibiotic doxycycline experienced no reduction in the growth of their aneurysm over two years compared to those who took a placebo, according to the study published today in the Journal of the American Medical Association (JAMA). The finding could lead doctors to stop prescribing the drug as a way to prevent small aneurysms from growing larger and bursting.. "This study provides strong evidence that doxycycline is of no benefit for patients with small abdominal aortic aneurysms in terms of preventing their growth. Health care providers should take note of the finding and stop using this as a prophylactic treatment," said corresponding author Michael Terrin, MDCM, MPH, Professor of Epidemiology and Public Health at UMSOM. ...
Management of ruptured abdominal aortic aneurysms. The latest evidence on the best way to manage a ruptured aneurysm will be presented including the one-year results of the IMPROVE trial and the IPD 3 trial. In the same session, the controversy as to whether many patients with ruptured abdominal aortic aneurysms are denied intervention will be discussed. Greenhalgh comments: "Perhaps doctors are becoming more concerned about operating for fear of having poor mortality figures. We need to find evidence whether indeed patients are denied intervention.". Janet Powell (Imperial College, London, UK), member of the CX Programme Organising Board, considers that a few patients are offered repair of ruptured aortic aneurysm because perhaps "not all centres have an endovascular team and facilities available at all times; additionally, there are financial stringencies on healthcare systems and many of these patients may need intervention out of hours." Holden adds that many questions on this subject remain ...
In many countries the gold standard for treating abdominal aortic aneurysms is still open surgery with a long incision. In patients with suitable anatomy alternatively an endovascular approach can be chosen. Since open surgery is more durable in many countries a laparoscopic procedure using key hole surgery has gained wider acceptance. The current study wants to prove that laparoscopic aortic aneurysm procedures are less invasive than open surgery with reduced recovery times.. Study design: Multi center prospective randomized study including patients with infra or juxtarenal aortic aneurysms ( AAA).. In group I the AAA is resected using a conventional long incision and standard procedures for resecting the AAA. A Dacron graft is used in inlay technique to restore blood flow.. In group II a total laparoscopic approach is chosen to exclude the AAA. Identical to open surgery a dacron graft is laparoscopically sawn in to exclude the AAA and to restore blood flow.. In a subgroup II a the ...
Searchers launched a study of more than three million people-by far the largest ever-to uncover what. St ascending aortic aneurysms are diagnosed in. Eurysm was noted during workup for back pain, and CT was ordered after AAA was identified on. aneurysm anu rizm a sac formed by the localized dilatation of the wall of an artery, a vein, or the heart. ThodsWe examined differences between England and the United. Dications for surgical treatment of thoracic aortic aneurysms (TAAs) are based on size or growth rate and symptoms. CT demonstrates abdominal aortic aneurysm (AAA). Thoracic aortic aneurysm (TAA) can be due to one of several etiologies. Historical perspective. 9 out of 10 Cardiovascular Doctors Support Preventive Health Screenings For People At Risk. E natural history of TAA is one of progressive expansion, the rate of which depending upon! Abdominal aortic aneurysm; Synonyms: triple a: CT reconstruction image of an abdominal aortic aneurysm (white arrows) Classification and external ...
Angiotensin IV (Ang IV), as an effector peptide of the rennin-angiotensin system, possesses many biological properties yet not completely known. In this study, we aimed to investigate the role of Ang IV in the development of Ang II-induced abdominal aortic aneurysm (AAA) in apolipoprotein E-knockout mice. We used Ang II infusion to induce AAA, and animals were treated with Ang II (1.44 mg/kg per day) plus no treatment, Ang II (1.44 mg/kg per day) plus low-, medium-, and high-dose Ang IV (0.72, 1.44, and 2.88 mg/kg per day, respectively). The incidence of AAA was 87.5%, 66.7%, 37.5%, and 83.3% in the no treatment, the low-, medium-, or high-dose Ang IV group, respectively. Compared with the no treatment group, medium-dose Ang IV treatment markedly reduced macrophage infiltration; levels of proinflammatory cytokines, including monocyte chemoattractant protein 1, interleukin 6, and intercellular adhesion molecule 1; the expression and activity of metalloproteinases 2 and 9; but increased smooth ...
January 20, 2016-Online in the Journal of Vascular Surgery (JVS), Diogo Silveira, MD, et al published findings for the late 3-year performance of total endovascular treatment of juxtarenal aortic aneurysms in octogenarians using the chimney/snorkel technique.. Between January 2009 and December 2014, endovascular aortic aneurysm repair was performed using the chimney/snorkel technique at one center in 35 high-risk octogenarian patients with juxtarenal aortic aneurysms who were unfit for open repair. Twenty-five patients (71.4%) were asymptomatic, and 10 patients were treated in an urgent care setting. The median follow-up was 36 months (range, 1-69 months). The primary endpoint was the survival rate.. As summarized in JVS, the investigators reported that the technical success rate was 100%. A single chimney graft placement was performed in 22 patients (62.9%), double chimneys were performed in 10 patients (28.6%), and triple chimneys were performed in three (8.5%) patients. Overall, 51 ...
To present the combined 14-year experience of 2 university centers performing endovascular aneurysm repair (EVAR) on 100% of noninfected ruptured abdominal aortic aneurysms (RAAA) over the last 32 months. Endovascular aneurysm repair for RAAA f
Introduction. Collagen is the most abundant protein in mammals and gives mechanical strength, stiffness and toughness to biological tissues like skin, tendon, bone, and vasculature [1]. Collagen fibrils of about 0.1 micrometers in diameters are the basic building blocks of fibrous collagenous tissues and their organization into suprafibrilar structures determines the tissues macroscopic mechanical properties. For example, detailed data regarding the organization of strong bundles of collagen might be critical to predict the onset of tissue failure, as it is clinically motivated by a rupture risk assessment of Abdominal Aortic Aneurysm (AAA). Previously proposed structural constitutive models for soft biological tissues [2, 3] integrated information regarding the collagen orientation, and regardless of their popularity, the requested microstructural information is not yet available in the open literature.. Method and Materials. The present study investigated the collagen formation in 12 AAA wall ...
Introduction. Collagen is the most abundant protein in mammals and gives mechanical strength, stiffness and toughness to biological tissues like skin, tendon, bone, and vasculature [1]. Collagen fibrils of about 0.1 micrometers in diameters are the basic building blocks of fibrous collagenous tissues and their organization into suprafibrilar structures determines the tissues macroscopic mechanical properties. For example, detailed data regarding the organization of strong bundles of collagen might be critical to predict the onset of tissue failure, as it is clinically motivated by a rupture risk assessment of Abdominal Aortic Aneurysm (AAA). Previously proposed structural constitutive models for soft biological tissues [2, 3] integrated information regarding the collagen orientation, and regardless of their popularity, the requested microstructural information is not yet available in the open literature.. Method and Materials. The present study investigated the collagen formation in 12 AAA wall ...
SCVS 2018 Abstracts: Statin Therapy is Associated with Higher Long-term, but not Perioperative Survival after Abdominal Aortic Aneurysm Repair
Learn more about Abdominal Aortic Aneurysm Repair at Sky Ridge Medical Center DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
TY - JOUR. T1 - BioPARR. T2 - A software system for estimating the rupture potential index for abdominal aortic aneurysms. AU - Joldes, Grand Roman. AU - Miller, Karol. AU - Wittek, Adam. AU - Forsythe, Rachael O.. AU - Newby, David E.. AU - Doyle, Barry J.. PY - 2017/7/5. Y1 - 2017/7/5. N2 - An abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is a symptomless condition that, if left untreated, can expand until rupture. Despite ongoing efforts, an efficient tool for accurate estimation of AAA rupture risk is still not available. Furthermore, a lack of standardisation across current approaches and specific obstacles within computational workflows limit the translation of existing methods to the clinic. This paper presents BioPARR (Biomechanics based Prediction of Aneurysm Rupture Risk), a software system to facilitate the analysis of AAA using a finite element analysis based approach. Except semi-automatic segmentation of the AAA and ...
Abdomen Aortic Aneurysm AAA Endovascular repair in Bangkok Thailand. Abdominal aortic aneurysm may not be noticeable, but deadly illness that is waiting to burst. We are fortuned to be living in a time where advanced medical technology and medical expertise can reduce the risk of death. Statistics have shown that 50 - 90% of patients overcome the disease. Our expert vascular surgeon shared with us his experience the treatment of abdominal aortic aneurysm. The aorta sends blood to each organ in the body, driven by the heart. Blood is supplied through the pulmonary artery, to the abdomen where the main artery splits into two just below the belly to supply the legs and pelvis. If there is any damage in this part of the blood vessel, the blood will seep out and will not be able to reach any other organ in the body, resulting in death. Abdominal aortic aneurysm is a condition where the blood vessel dilates to more than 1.5 - 2 cm in diameter. The cause is unclear; risk factors are smoking, ...
BACKGROUND: Open abdomen treatment (OAT) is considered a lifesaving procedure in patients with abdominal compartment syndrome (ACS) after endovascular or open intervention for ruptured abdominal aortic aneurysms (RAAA). Standardized treatment methods and algorithms for its use are still lacking. The high, published mortality rates may reflect difficulties in detecting and treating ACS, especially in patients treated by emergency endovascular aneurysm repair (eEVAR). Presented are standardized algorithms for OAT, including a new technique using the vacuum-assisted closure (VAC) system developed during 10 years of experience with eEVAR for RAAA. METHODS: We retrospectively analyzed 102 patients with RAAA treated by eEVAR from January 1998 to April 2008. Abdominal decompression was done when intravesical pressure ,20 mm Hg or when abdominal perfusion pressure was ,50 to 60 mm Hg and concomitant organ deterioration occurred. OAT was initially done with a subcutaneously sutured plastic bag or with a ...
An aneurysm occurs when a blood vessel becomes abnormally large or balloons outward. The abdominal aorta is a large blood vessel that supplies blood to your abdomen, the pelvis, and legs. When a weak area of the abdominal aorta grows, it is called an abdominal aortic aneurysm (AAA). AAA can develop in anyone, but it is primarily seen in men over 60 with one or more risk factors. The larger the aneurysm, the more likely it is to rupture which can cause massive internal bleeding and can be fatal. When diagnosed early, abdominal aortic aneurysms can be treated, or even cured, with highly effective and safe treatments ...
Objective To assess the incidence and risk factors for proximal aneurysm neck related complications with a late generation device for endovascular abdominal aneurysm repair (EVAR). Methods Data were retrieved from a prospective registry (Endurant Stent Graft Natural Selection Global Postmarket Registry) involving 79 institutions worldwide. The risk factors tested were ... read more age, gender, surgical risk profile, proximal neck length (30 mm), supra- and infrarenal angulation (,60° and 75°), mural thrombus/calcification (,50%) and taper (,10%), and AAA diameter (,65 mm). Two neck related composite endpoints were used, for intra-operative (type-1a endoleak, conversion, deployment/retrieval complication or unintentional renal coverage) and post-operative (type-1a endoleak or migration) adverse events. Independent risk factors were identified using multivariable backwards modeling. Results The study included 1263 patients (mean age 73, 10.3% female) from March 2009 to May 2011. Twenty three ...
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. Markers of oxidative stress and systemic inflammation were measured as well ...
Approach and Results-We report that administration of deoxycorticosterone acetate (DOCA) and salt or aldosterone and salt, but not DOCA or salt alone, to C57BL/6 male mice induced abdominal and thoracic aortic aneurysm formation and rupture in an age-dependent manner. DOCA and salt- or aldosterone and salt-induced aortic aneurysm mimicked human aortic aneurysm with respect to elastin degradation, inflammatory cell infiltration, smooth muscle cell degeneration and apoptosis, and oxidative stress. Aortic aneurysm formation did not correlate with the increase in blood pressure induced by DOCA and salt. Systemic administration of the angiotensin-converting enzyme inhibitor, enalapril, or angiotensin type 1 receptor antagonist, losartan, did not affect DOCA and salt-induced aortic aneurysm. In contrast, the mineralocorticoid receptor antagonists, spironolactone or eplerenone, significantly attenuated DOCA and salt- or aldosterone and salt-induced aortic aneurysm.. ...
An abdominal aortic aneurysm (AAA) is when the lower part of the aorta becomes enlarged, like a balloon. The aorta is the largest artery in the body. It carries blood from the heart down along the backbone where it splits into many smaller arteries that bring blood to all of the organs. Aneurysm is a general term that describes an enlargement of any blood vessel in the body. Aneurysms usually develop slowly over time and may not cause problems until they become so enlarged that they can rupture.. Smaller AAAs generally do not cause symptoms. Larger AAAs can cause symptoms such as a pulsating feeling near the belly button, deep and constant abdominal pain, or back pain. Rupture of an aortic aneurysm is a medical emergency. If an aortic aneurysm ruptures, symptoms include vomiting, intense pain, excessive sweating, a drop in blood pressure, fainting, and shortness of breath.. AAAs can be caused by stiffening of the artery walls due to plaque build up (atherosclerosis), infection of the aorta, or ...
Alternative treatments for abdominal aortic aneurysm - Are there effective natural treatments for abdominal aortic aneurysm? No. Basically, trying to prevent the AAA from rupturing or leaking. This can be done with surgery (open vs. Placed via blood vessel) or with medical management and follow-up. The most "natural" thing is to do nothing, but this has a much higher death rate than surgical repair or blood pressure control with meds. Avoiding stress, tobacco, etc. May help keep BP down when used in conjunction with meds.
Endothelial dysfunction is observed in patients with abdominal aortic aneurysm (AAA), who have increased risk of cardiovascular events and mortality. This study aimed to assess the acute effects of moderate and higher-intensity exercise on endothelial function, as assessed by flow-mediated-dilation (FMD), in AAA patients (n=22; 74±6 y) and healthy adults (n=22; 72±5y). Participants undertook three randomised visits, including moderate-intensity continuous exercise (40% peak power output, PPO), higher-intensity interval exercise (70% PPO), and a no-exercise control. Brachial artery FMD was assessed at baseline, 10- and 60-min after each condition. Baseline FMD was lower in AAA patients compared to healthy adults [by 1.10%, (95% CI, 0.72 to 1.81), P=0.044]. There were no group differences in the FMD responses after each condition (P=0.397). FMD did not change after the control condition, but increased by 1.21% (95% CI, 0.69 to 1.73, P|0.001) 10 min after moderate-intensity continuous exercise in both
Hey, guys and gals, another thing you need to be vigilant for is an abdominal aortic aneurysm. Though anyone can get them, they seem to be more prevalent in men than women and are a leading cause of death in older men. An abdominal aortic aneurysm, or AAA, is a weak spot in an artery wall in the stomach and can be hereditary and is also more common in smokers. You can and should get a screening to make sure youre not going to have one of these. Should something be found, modern medicine has a much easier way of treating it now than in the past. Nowadays, this can be repaired under local anesthetic (if you have the stomach for it!) and only takes about five days for recovery. ...
European Heart Journal - Cardiovascular Imaging (2012) 13, 574-578 doi:10.1093/ejechocard/jer260 Screening for abdominal aortic aneurysm in coronary care unit patients with acute myocardial infarction using portable transthoracic echocardiography 1 Cardiology Department, AP-HP, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France; 2INSERM U698, Paris, France; and 3University Paris 7, Paris, France Received 30 August 2011; accepted after revision 31 October 2011; online publish-ahead-of-print 29 November 2011 Aims Patients with acute myocardial infarction (AMI) represent a high-risk population in which screening for abdominal aortic aneurysm (AAA) is recommended but only occasionally performed. Transthoracic echocardiography (TTE) may offer the unique opportunity to evaluate the cardiac function and to screen for AAA during the same examination. We aimed to evaluate the feasibility of AAA screening at bedside using a portable cardiac ultrasound (US) echo machine and to determine the ...
Typically contrast images are not necessary in the case of an acute abdominal aortic aneurysm rupture. This was acquired and shows a very dramatic rupture with a huge amount of active contrast extravasation in keeping with acute haemorrhage.
To provide the most rigorous possible test of the utility of screening, we designed the trial as a population based study with the primary end point, mortality from abdominal aortic aneurysm, to be analysed on an intention to treat basis. We planned to have 90% power to detect and declare significant (two sided α = 0.05) a relative reduction of 50% in mortality among men invited for screening over five years from the start of screening. Using available pilot data, we estimated that the control group would need to contain about 20 000 men to experience 55 deaths from abdominal aortic aneurysm.3. Men were identified from an electronic copy of the electoral roll, enrolment to vote being compulsory for all Australian adults. The ideal target age range for screening is 65-74 years, but the electoral roll listed fewer than 40 000 men in this age group in the main metropolitan area of Perth (the capital city of Western Australia) and satellite towns. The addition of men aged 75-79 years increased the ...
Abdominal Aortic Aneurism is a condition when large blood vessels responsible for supplying blood to the abdomen, legs and pelvis become unusually large or inflates in an outward direction. Aneurism has been particularly categorized into three groups, viz. genetically inherited diseases, enzyme destruction, and lifestyle-influenced conditions.The risk factors of an abdominal aortic aneurism include smoking, obesity, high cholesterol, high blood pressure, emphysema and genetic factors. It generally develops in males over the age of 60 experiencing any of these risk factors. The symptoms mostly include severe abdomen or back pain, nausea, vomiting, clammy skin, rapid heart rate and shock.. ...
Title: MedicineNet Abdominal Aortic Aneurysm Specialty, Description: MedicineNet Abdominal Aortic Aneurysm Specialty, By: Feedage Forager, ID: 330969, Grade: 91, Type: RSS20
Elective EVAR using the Cook Zenith endograft provides excellent results through a mean follow-up of |5 years. There is a low aneurysm-related mortality and an acceptable rate of postoperative complications and reinterventions. The occurrence of late complications throughout the follow-up period …
Approach and Results-AAA was induced in low-density lipoprotein receptor-null (Ldlr-/-) mice by infusing angiotensin II. Nox2 expression was elevated in the abdominal aortae of these mice during infusion of angiotensin II, with enhanced Nox2 expression mainly because of the recruitment of NOX2-enriched macrophages into AAA lesions. Unexpectedly, systemic Nox2 deficiency promoted AAA development but reduced the level of reactive oxygen species in AAA lesions. Nox2 deficiency stimulated macrophage conversion toward the M1 subset, enhancing expression of interleukin (IL)-1β and matrix metalloproteinase-9/12 mRNA. Administration of neutralizing antibody against IL-1β abolished AAA development in Nox2-deficient mice. Bone marrow transplantation experiments revealed that AAA aggravation by Nox2 deficiency is because of bone marrow-derived cells. Isolated bone marrow-derived macrophages from Nox2-null mice could not generate reactive oxygen species. In contrast, IL-1β expression in peritoneal and ...
Highlighted review Ultrasonography for endoleak detection after endoluminal abdominal aortic aneurysm repair available now ...
TWENTY YEARS LATER WE REMEMBER DECEMBER 3RD, 1999, AS THE LAUNCH OF THE NEW ERA OF ENDOVASCULAR ANEURYSM REPAIR IN EAST TENNESSEE. Open surgical repair was the standard method of aneurysm repair for five decades. Dr. Juan Parodi, Dr. Julio Palmaz and Dr. Nicholas Volodos are recognized as pioneers of endovascular aneurysm repair. Dr. Parodi […]. Read More » Tags: AAA repair, abdominal aortic aneurysm, Dr. George Pliagas, Premier Surgical Associates, Premier Surgical Associates of Knoxville, surgery in Knoxville, surgery in Tennessee, vascular surgeon. ...
RADIOLOGY: AORTA: Case# 27: LEAKING ABDOMINAL AORTIC ANEURYSM. 84-year-old male with a known abdominal aortic aneurysm who presents with severe abdominal pain. There is a very large abdominal aortic aneurysm which begins between the origin of the superior mesenteric artery and the renal artery and extends into the aortic bifurcation to involve the right common iliac artery. At its greatest dimensions, it measures 15.0 cm x 10.0 cm and contains a large amount of intramural thrombus. The aortic aneurysm is eccentric in location, residing more in the right side of the retroperitoneum. There is a moderate amount of hemorrhage within the right side of the retroperitoneum surrounding the aneurysm consistent with subacute hemorrhage. No active arterial extravasation is identified at this time. Abdominal aortic aneurysms usually occur in the setting of atherosclerotic disease but may be caused by syphilis, by extension of a dissection from above, or by connective tissue disorders such as Takayasus arteritis
RADIOLOGY: AORTA: Case# 27: LEAKING ABDOMINAL AORTIC ANEURYSM. 84-year-old male with a known abdominal aortic aneurysm who presents with severe abdominal pain. There is a very large abdominal aortic aneurysm which begins between the origin of the superior mesenteric artery and the renal artery and extends into the aortic bifurcation to involve the right common iliac artery. At its greatest dimensions, it measures 15.0 cm x 10.0 cm and contains a large amount of intramural thrombus. The aortic aneurysm is eccentric in location, residing more in the right side of the retroperitoneum. There is a moderate amount of hemorrhage within the right side of the retroperitoneum surrounding the aneurysm consistent with subacute hemorrhage. No active arterial extravasation is identified at this time. Abdominal aortic aneurysms usually occur in the setting of atherosclerotic disease but may be caused by syphilis, by extension of a dissection from above, or by connective tissue disorders such as Takayasus ...
Introduction Prevalence of abdominal aortic aneurysm is 2-6%. Aneurysm is on the leading possitions in death cause. Lot of patients die do to ruptured aneurysm. The etiology of abdominal aortic aneurysm remains unknown. Current treatment(resection or endovascular)is not indicated for everyone. We don´t know the right conservative (pharmacological) treatment. Aims With our study, we would like to confirm the impact of atorvastatin on experimental abdominal aortic aneurysm. We would like to evaluate and quantified changes in the composition of an aneurysmatic wall under the effect of atorvastatin. Other aim is to make a summary of known knowledge of this disorder. These knowledges can help in searching for new treatment options. Methods Comparison of 2 groups of pigs with experimental abdominal aortic aneurysm. Group treated with atorvastatin and group without any pharmacological influencing. Comparing of aneurysmal growth rate. Evaluation of changes of the wall structure in both groups using a ...
Epidemiologic research has shown a correlation between cigarette smoke and the risk of developing atherosclerosis and associated pathological processes including abdominal aortic aneurysms (AAA). Hyperlipidemia and hypertension are additional risk factors for atherosclerosis. The hyperlipideamic apolipoprotein e-knockout (ApoE-/-) mouse is a well-established animal model system for studying the mechanisms of the atherosclerotic process. In this study, we examined the mechanistic effects occurring as three risk factors interact in the atherosclerotic process. Hypertension was induced in hyperlipidemic apolipoprotein-e-knockout (ApoE-/-) mice by application of angiotensin-II and the mice were exposed to mainstream smoke from the reference cigarette 2R4F (University of Kentucky) for 30 days. AAA formation was seen only in angiotensin-ii treated ApoE-/--mice. The incidence and severity of AAA were further increased by smoke exposure. Expression of matrix metalloproteinases-(MMP)-2, -3, -8, -9, and ...
Abdominal Aortic Aneurysm (AAA) Screening is now available in MPHC The 4th Practice in conjuction with Affidea. What is an AAA?. The aorta is the main vessel carrying blood around your body. In some people, especially older men, the wall of the aorta gradually weakens and starts to expand. See diagrammatic illustration below.. Is an AAA serious?. Large AAA are rare, but can be very serious. As the aorta expands it can burst, and the person usually dies. Small/medium sized AAA are not as dangerous, and your consultant vascular surgeon will arrange ultrasound monitoring to see if it gets bigger.. Is Screening for AAA important, and why are you invited?. Most people with AAA have no symptoms. A simple painless ultrasound scan of your tummy will tell if you have an AAA. We are inviting men only, as AAA are six times more common in men than women. Ruptured AAA mostly happens to men. You also are more likely to have an AAA if you you smoke, have high blood pressure or your parent, brother or sister ...
The Relationship between Patent Vessels that Arise from the Aneurysmal Sac and Early Endoleak Purpose: To determine the association of patent sac branch vessels (lumbar and inferior mesenteric arteries [IMAs]) with early endoleak rate after stent-graft repair of abdominal aortic aneurysm (AAA). Materials And Methods: Pre- and postoperative computed tomographic (CT) angiograms in 158 patients…
Abdominal aortic aneurysm (AAA) repair is done to treat an aneurysm. An aneurysm is a bulging, weak spot in the aorta that may be at risk for rupturing. In this case, the aneurysm is in part of the aorta that is in the abdomen.
Abdominal aortic aneurysm (AAA) repair is done to treat an aneurysm. An aneurysm is a bulging, weak spot in the aorta that may be at risk for rupturing. In this case, the aneurysm is in part of the aorta that is in the abdomen.
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall stress, deformation, and fluid flow dynamic over a period of time. The model estimated the time to rupture based on the effects of hypertensive blood pressure and degradation of the diseased aortic wall mechanical properties.. ...
Coronary artery disease (CAD) was evaluated by noninvasive examination in abdominal aortic aneurysm (AAA) patients. A simultaneous operation or a 2-staged operation was performed depending on the seriousness of the condition when both diseases were combined. A total of 36 patients underwent elective repair of AAA between 1996 and 2001. Coronary angiography (CAG) was performed only in patients with suspected CAD by dipyridamole myocardial scintigraphy. Significant CAD was found in 8 patients. Simultaneous operation was performed in 4 patients, and off-pump coronary artery bypass grafting (OPCAB) was performed in all cases of simultaneous operation. In 4 patients receiving 2-staged operations, 1 standard coronary artery bypass grafting (CABG), 1 OPCAB and 2 percutaneous transluminal coronary angioplasties (PTCA) were performed prior to AAA surgery. Twenty-eight patients underwent only AAA operation. Though there were no incidents of perioperative myocardial infarction or cardiac related deaths in ...
Background Research: The definition of an aneurysm is permanent, localised dilatation of a blood vessel or heart chamber. The abdominal aorta is the largest blood vessel in the human body and usually has a diameter of 1.8 -2.0 centimetres (cm), dependant on age, sex and body habitus. Aortic dilatation is generally classed as an aneurysm when dilation of the vessel is 1.5 times the normal size. An abdominal aortic aneurysm (AAA) affects any part of the aorta below the diaphragm with 80 % typically being found between the renal artery and aortic bifurcation. Risk Factors There are many factors that relate to the development of AAA. Gender is one of the biggest non-modifiable risk factors, as an AAA is four to six times more likely in males compared with females. Furthermore, the development of AAA in females occurs approximately ten years later than males. The risk of AAA also increases if there is family history of the disease, especially if the relative is first degree. There is also ...
Abdominal aortic aneurysm (AAA) rupture represents a major cardiovascular risk, combining complex vascular mechanisms weakening the abdominal artery wall coupled with hemodynamic forces exerted on the arterial wall. At present, a reliable method to predict AAA rupture is not available. Recent studies have introduced fluid structure interaction (FSI) simulations using isotropic wall properties to map regions of stress concentrations developing in the aneurismal wall as a much better alternative to the current clinical criterion, which is based on the AAA diameter alone. A new anisotropic material model of AAA that closely matches observed biomechanical AAA material properties was applied to FSI simulations of patient-specific AAA geometries in order to develop a more reliable predictor for its risk of rupture. Each patient-specific geometry was studied with and without an intraluminal thrombus (ILT) using two material models-the more commonly used isotropic material model and an anisotropic ...
The US Preventative Services Task Force (USPSTF)have recommended that men aged 65 to 75 who have ever smoked should get an ultrasound to screen for Abdominal Aortic Aneurysm (AAA).. Why is screening important? Most AAAs are "silent" until they rupture and AAA ruptures are often fatal.. The Mayo Clinic defines an AAA as "An abdominal aortic aneurysm is an enlarged area in the lower part of the aorta, the major blood vessel that supplies blood to the body. The aorta, about the thickness of a garden hose, runs from your heart through the center of your chest and abdomen. Because the aorta is the bodys main supplier of blood, a ruptured abdominal aortic aneurysm can cause life-threatening bleeding". Screening for an AAA is an easy procedure - its simply an ultrasound of your abdomen, concentrating on the aorta. Canada Diagnostic Centres has been providing AAA screening since 2007 and patients often combine this screening test with our other screening exams for early detection of disease.. What ...
Stent graft devices for the treatment of abdominal aortic aneurysms (AAAs) are being in-creasingly used worldwide. Yet, during modelling and optimization of these devices, as well as in clinical practice, vascular sections are idealized, possibly compromising the effective-ness of the intervention. In this study, we challenge the commonly used approximation of the circular cross-section of the aorta and identify the implications of this approximation to the mechanical assessment of stent grafts. Using computed tomography angiography (CTA) data from 258 AAA patients, the lumen of the aneurysmal neck was analysed. The cross-section of the aortic neck was found to be an independent variable, uncorrelated to other geometrical aspects of the region, and its shape was non-circular reaching elliptical ratios as low as 0.77. These results were used to design a finite element analysis (FEA) study for the assessment of a ring stent bundle deployed under a variety of aortic cross-sections. Re-sults showed ...
Open Repository is based on and contributes to DSpace the open source tool for the management of digital assets. Open Repository is a service operated by Atmire. ...
An endovascular stent graft is placed inside the abdominal aortic aneurysm to help prevent rupture. Medtronic is a leading developer of endovascular stent grafts.
Primary among the mechanical factors linked with abdominal aortic aneurysm (AAA) rupture is peak wall stress, frequently quantified as either the maximum principal or Von Mises stress exerted along the diseased arterial wall. Intraluminal pressure, as an impinging normal force on the wall, has been hypothesized as the dominant influence on this stress and thus the majority of numerical modeling studies of AAA mechanics have focused on static computational solid stress (CSS) predictions [1,2]. Unfortunately, retrospective studies comparing the magnitude of wall stress with the failure strength of the aneurysmal wall have yet to consistently predict the outcome for patient-specific AAAs [3,4]. Previous studies have shown that hemodynamics also plays a significant role in both the biological and mechanical factors that exist within AAAs. In the present investigation, partially and fully coupled fluid-structure interaction (p-FSI and f-FSI, respectively) computations of patient-specific AAA models ...
Many asymptomatic patients with a small abdominal aortic aneurysm (AAA) are diagnosed incidentally during routine abdominal screening. However, there is no effective treatment option for small AAA despite their gradual expansion. Angiotensin II is thought to induce and perpetuate inflammation in the aortic wall, and previous studies reported the inhibitory effects of angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors in experimental studies. However, there is no evidence for a beneficial effect of these medicines on AAA progression in clinical trials. Therefore, we focused on direct renin inhibition, because inhibition of multiple steps of the renin-angiotensin system might be required for treating AAA. The present study reported the inhibitory effect of direct renin inhibition on experimental AAA expansion associated with a significant reduction of excess renin-angiotensin system activation in the aneurysm wall. In addition, significant inhibition of activation of ...
TY - JOUR. T1 - Operative and Midterm Outcomes of the Fenestrated Anaconda Stent-Graft in the Endovascular Treatment of Juxtarenal, Suprarenal, and Type IV Thoracoabdominal Aortic Aneurysms. AU - Kotelis, Drosos. AU - Schleimer, Karina. AU - Foldenauer, Christina. AU - Jalaie, Houman. AU - Grommes, Jochen. AU - Jacobs, Michael J.. AU - Kalder, Johannes. PY - 2016/12. Y1 - 2016/12. KW - abdominal aortic aneurysm. KW - endoleak. KW - endovascular aneurysm repair. KW - fenestrated stent-graft. KW - juxtarenal aneurysm. KW - mortality. KW - reintervention. KW - suprarenal aneurysm. KW - thoracoabdominal aortic aneurysm. U2 - 10.1177/1526602816667281. DO - 10.1177/1526602816667281. M3 - Article. VL - 23. SP - 930. EP - 935. JO - Journal of Endovascular Therapy. JF - Journal of Endovascular Therapy. SN - 1526-6028. IS - 6. ER - ...
SCVS 2018 Abstracts: Impact of Secondary Interventions on Mortality after Fenestrated Branched Endovascular Aortic Aneurysm Repair
Learn more about Endovascular Repair of Abdominal Aortic Aneurysm at Medical City Dallas DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall ...
Several studies have demonstrated that AngII infusion leads to the formation of AAAs in mice.12,13,50 AngII exerts its diverse bioactive effects primarily by activating the AT1a receptor in mice, which plays a critical role in AngII-induced AAA development.17 In addition to mediating traditional G-protein-dependent signaling, the AT1a receptor is involved in G-protein-independent signaling by forming a complex with the multifunctional scaffolding protein βarr2.19,24 In the present study, we investigated a role for βarr2 in AngII-induced AAA formation and found that βarr2 deficiency significantly attenuates AAA formation in mice both on a hyperlipidemic apoE background and on a normolipidemic C57BL/6 background (Figure 1). These studies suggest that G-protein-independent, βarr2-dependent signaling for the AT1a receptor plays a major role in AngII-induced AAA formation.. Although our present studies showed that βarr2 deficiency attenuated AngII-induced AAA formation in mice on the ...
Desgranges P, Kobeiter H, Katsahian S, et al. Editors choice - ECAR (endovasculaire ou chirurgie dans les anévrysmes aorto-iliaques rompus): a French randomized controlled trial of endovascular versus open surgical repair of ruptured aorto-iliac aneurysms. Eur J Vasc Endovasc Surg. 2015;50(3):303-310. PMID: 26001320 www.ncbi.nlm.nih.gov/pubmed/26001320.. Holt PJE, Thompson MM. Abdominal aortic aneurysms: evaluation and decision making. In: Cronenwett JL, Johnston KW, eds. Rutherfords Vascular Surgery. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 130.. Lal BK, Zhou W, Li Z, et al. Predictors and outcomes of endoleaks in the veterans affairs open versus endovascular repair (OVER) trial of abdominal aortic aneurysms. J Vasc Surg. 2015;62(6):1394-1404. PMID: 26598115 www.ncbi.nlm.nih.gov/pubmed/26598115.. Tracci MC, Cherry KJ. The aorta. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 20th ed. Philadelphia, PA: Elsevier; 2017:chap 61. ...
1. Marshall G. Screening for abdominal aortic aneurysm - does it fulfill the criteria for mass screening? Radiography. 1996; 2:3-9. http://dx.doi.org/10.1016/S1078-8174(96)90029-2.. 2. Scott R, Vardulaki K, Walker N, Day N, Duffy S, Ashton H. The long-term benefits of a single scan for abdominal aortic aneurysm (AAA) at age 65. Eur J Vasc Endovasc. 2001; 21:535-40. http://dx.doi.org/10.1053/ejvs.2001.1368.. 3. Scott R, Bridgewater S, Ashton H. Randomized clinical trial of screening for abdominal aortic aneurysm in women. Brit J Surg. 2002; 89:283-5. http://dx.doi.org/10.1046/j.0007-1323.2001.02014.x.. 4. Heronm M, Hoyert D, Murphy S, Xu J, Kochanek K,Tejada-Vera B. Deaths: final data for 2006. Natl Vital Stat Rep. 2009; 57(14):34-86. http://www.cdc.gov/nchs/data/nvsr/nvsr57/nvsr57_14.pdf. 5. Bown M, Sutton A, Bell P, Sayers R. A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair. Brit J Surg. 2002; 89:714-30. http://dx.doi.org/10.1046/j.1365-2168.2002.02122.x.. 6. UK Small ...
Some abdominal aortic aneurysms can be repaired using endovascular stent grafting. Medtronic AneuRx AAAdvantage and Talent Abdominal Stent Grafts are used for this procedure.
A role of ACE I/D polymorphism in the pathogenesis of abdominal aortic aneurysm (AAA) has been demonstrated, possibly due to the effect of angiotensin II on vascular tissue remodelling. Angiotensin II exerts profibrogenic effects through the local induction of TGF-. Dysregulated TGF- signalling may result from mutations in TGFBR1 and TGFBR2 genes, thus resulting in degenerative changes in the vessel wall. We performed a case-control study in order to investigate the role of TGFBR1 9A6A polymorphism as predisposing factor to AAA per se, and in the presence of ACE DD and AT1R 1166 CC genotypes in 201 AAA patients (mean age ± S.D., 71.5 ± 6.9) referred to the Unit of Vascular Surgery of the University of Florence, compared with 252 healthy controls (mean age ± S.D., 70.6 ± 8.6). A significant difference in genotype distribution and allele frequency between patients and controls was found for ACE, but not for AT1R and TGFBR1 polymorphisms. At univariate analysis a significant association between ...
Even though multiple etiological, genetic, and environmental factors contributing to AAA have been identified in the past decade, the mechanisms leading to terminal aorta weakening and ultimate rupture are still incompletely understood. Gene expression array analyses provide a comprehensive, global view of disease‐related genes, as well as of activated or inactivated pathways.. There have been a few earlier investigations with different study designs using gene expression array analyses from AAA patients,20, 21, 22, 23, 24, 25 but this is the first study using whole genome microarrays to compare relative mRNA expression patterns between stable and ruptured AAAs in order to identify processes associated with AAA progression and rupture. With our approach we were able to identified and validate 2 gene sets. The first gene set relates to AAA growth and rupture (terminal progression-associated genes). A second set of 5 candidate genes (STC1, ADAMTS9, GFPT2, GAL3ST4, and CCL4L1) showed no ...
April 1, 2009 - Endovascular aortic repair (EVAR) used to repair ruptured abdominal aortic aneurysms (RAAAs) had a significant mortality benefit, according to five-year study published in the April issue of the Journal of Vascular Surgery.. The study, conducted by researchers from the University of Massachusetts Memorial Medical Centers division of vascular and endovascular surgery in Worcester, examined the national frequency, predictors, outcomes, and the effect of institutional volume metrics in cases where endovascular aortic repair (EVAR) was used to repair ruptured abdominal aortic aneurysms (RAAAs) between 2001 and 2006.. Over the years EVAR has gained wide acceptance for the elective treatment of abdominal aortic aneurysms (AAA). This success has led to increased interest in similar treatment of RAAAs, because most patients who suffer a RAAA do not survive long enough to obtain medical care. The mortality rate for patients who do survive and undergo traditional open surgical repair ...
Most aortic aneurysms occur in the part of your aorta thats in your abdomen. Although the exact cause of abdominal aortic aneurysms is unknown, a number
Is the rupture rate falling? Janet Powell, London,UK, told delegates that the rate and volume of aneurysm rupture is declining. She made the point that smoking prevalence had decreased, and use of lipid-lowering and antihypertensive drugs had increased in those who were 65+ years. "The small aneurysm rupture rate is decreasing and deaths from (and hospital admissions for) large ruptured aneurysm are decreasing. Since selection for repair and its mortality are unchanged, have cardiovascular risk prevention programmes pre-empted national aneurysm screening programmes?" she asked. Martin Bjorck, Uppsala, Sweden, told delegates that an aneurysm screening programme should include a smoking cessation programme, promotion of exercise and healthy diet and statin treatment prior to surgery. There should also be hypertension treatment, according to standard of care, he said. "As we all know, screening elderly men for abdominal aortic aneurysm, and repair of those who have or later develop large aneurysms, ...
Degradation of the elastic media is a hallmark of abdominal aortic aneurysms (AAAs). We examined the expression of 2 elastolytic matrix metalloproteinases (MMPs), MMP-2 and MMP-9, in AAA aortic tissues compared with those from atherosclerotic occlusive disease (AOD) and nondiseased control tissues. Quantitative competitive reverse transcription-polymerase chain reaction and gelatin zymography showed increased MMP-9 mRNA and protein in both AAA and AOD tissues compared with those in control tissue, but there was no significant difference between AAA and AOD. In contrast, MMP-2 mRNA and protein levels were significantly higher in AAA than in AOD or control tissues. Sequential extraction of the MMPs from the aortic tissue with a physiological salt solution, 2% dimethylsulfoxide (DMSO), and 10 mol/L urea showed that large amounts of MMP-2 and MMP-9 were bound to the matrix. The most conspicuous finding was that the levels of MMP-2 were significantly elevated in the DMSO fraction in AAA tissues compared with
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin. This review examines evidence from these animal studies and related reports of inhibition of inflammation and arrest of aneurysm development following prophylactic supplementation with LC n-3 PUFAs. The efficacy of LC n-3 PUFAs for management of existing aneurysm is
BACKGROUND: The aim of this study was to investigate trends in population-based mortality, hospital admission and case fatality rates for abdominal aortic aneurysm (AAA) from 1979 to 1999. METHODS: This was an analysis of routine statistics from 79 495 death certificates in England and Wales and 3217 hospital inpatient admissions in the Oxford Region. RESULTS: Mortality rates for all AAAs increased between 1979 and 1999 from 13 to 25 per million in women and from 80 to 115 per million in men. Admission rates increased in the same time interval from three to 22 admissions per million per year in women, and from 52 to 149 per million per year in men. Case fatality rates for all non-ruptured AAAs that were operated on decreased from 25.8 to 9.0 per cent and for all ruptured AAAs from 69.9 to 54.4 per cent. CONCLUSION: Mortality rates and hospital admission rates for AAA rose in men and even more so in women between 1979 and 1999. Perioperative mortality for ruptured AAA declined a little during the study
Cinà CS, Devereaux PJ. Endovascular and open repair did not differ for mortality rates at 2 years in abdominal aortic aneurysm. ACP J Club. 2005;143:64. doi: 10.7326/ACPJC-2005-143-3-064. Download citation file:. ...
This study was designed to evaluate the optimal surgical treatment strategy for abdominal aortic aneurysm (AAA) coexisting with coronary artery disease (CAD). Twenty-six patients (21 men and 5 women with a mean age of 72.6 }3.7years old) who required surgical treatment of both conditions were examined. Eleven patients underwent a one-stage operation. Four of them had on-pump CABG and 7, including 3 high-risk-patients, underwent off-pump CABG. There were no operative mortalities, but 3 patients had severe morbidity (respiratory failure, acute renal failure, pneumonia). Fifteen patients underwent a two-stage operation. None of them had rupture of the AAA during the interval between the two operations, but 2 patients with large AAA (more than 6cm in diameter) required emergency operation due to impending rupture of the AAA. There was no operative mortality, but one patient suffered acute renal failure. One-stage operation for low-risk patients seems to be a safe and reasonable strategy. One-stage ...
Although we successfully excluded aneurysmal segments immediately in all cases in which the homemade device functioned appropriately, our experience should be qualified. We used a model of AAA in healthy, nonatherosclerotic swine. Even after balloon overstretch injury, the course of the infrarenal aorta remained essentially unchanged. This and more complicated surgical models cannot represent the complex 3D anatomy and tortuosity encountered clinically in degenerative arterial segments in patients with AAA, in whom the expected benefits of detailed soft tissue contrast and 3D representation by MRI may be more dramatic. In particular, safe traversal of tortuous iliac artery segments, one of the procedural challenges of AAA endografting, might be simplified by using rtMRI to visualize device-related anatomic distortion and to guide operator adjustments. Furthermore, we used a simple tubular endograft, although most clinical devices are bifurcated to cover the aorta and both iliac limbs.. Our ...
Abdominal aortic aneurysm (AAA) is a common disease for which mechanisms of formation are still not well understood. Despite a strong genetic component to AAA risk, specific risk alleles are still largely unidentified. AAA is also a localized disease with a majority occurring in the infrarenal abdominal aorta and is six times more common than aneurysms of the thoracic aorta. To determine whether risk alleles are present in functional positional candidate genes. we: 1. performed a genetic association study using DNA from AAA cases and controls in ten candidate genes and 2. performed exon sequencing on three genes with evidence of nominal association. To identify genes with regional expression in the aorta of potential relevance to AAA: 1. Illumina microarrays were used to perform a gene expression profiling of entire baboon aortas and 2. protein expression of one candidate gene, HOXA4, was examined in further detail. Single nucleotide polymorphisms in three positional candidate genes, CEBPG, PEPD and
An abdominal aortic aneurysm (AAA) is a potentially fatal cardiovascular disease with multifactorial development and progression. Two preclinical models of the disease (elastase perfusion and angiotensin II infusion in apolipoprotein-E-deficient animals) have been developed to study the disease during its initiation and progression. To date, most studies have used |i|ex vivo|/i| methods to examine disease characteristics such as expanded aortic diameter or analytic methods to look at circulating biomarkers. Herein, we provide evidence from |i|in vivo|/i| ultrasound studies of the temporal changes occurring in biomechanical parameters and macromolecules of the aortic wall in each model. We present findings from 28-day studies in elastase-perfused rats and AngII |i|apoE|sup|−/−|/sup||/i| mice. While each model develops AAAs specific to their induction method, they both share characteristics with human aneurysms, such as marked changes in vessel strain and blood flow velocity. Histology and
Friedrichshafen Clinic in Germany offers top-end surgical treatment for abdominal aortic aneurism. The department of general, visceral and vascular surgery, guided by Prof. Dr. Thorsten Lehmann, uses a wide range of traditional and new methods for abdominal aneurism treatment: open surgery; endovascular therapy, laparoscopic surgery, endovascular implants etc.
In an attempt to chart the changing rates of open, EVAR and branched/fenestrated EVAR repairs over the past decade, Suckow and colleagues used a query of Medicare claims data from 2003-2013 involving abdominal aortic aneurysm repairs (excluding open repairs with any thoracic component but including juxta-/pararenal procedures).. The data gathered showed a 20% decline in all forms of abdominal aortic aneurysm repair to approximately 24,000 repairs in 2013 following a peak of approximately 30,000 in 2005. Breaking these figures down by procedure type, the number of EVAR procedures grew by 74% from 2003-2008 before falling by 13% to 2013. Open repair saw a prolonged and significant decline from 2003 to 2013, falling by 78%. Less than 4,000 open repair Medicare procedures were completed in 2013, Suckow said. Branched/fenestrated EVAR-first coded by Medicare in 2011-has since increased by 504% and by 2013 was as common as open repair.. As well as looking at the total number of repairs, the team also ...
August 1994). "Design of the abdominal aortic Aneurysm Detection and Management Study. ADAM VA Cooperative Study Group". J Vasc ... "The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a ... which found reduced mortality after screening for abdominal aortic aneurysms in the UK.[2] ... for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms ...
... (英语:abdominal aortic aneurysm, AAA[1]),為腹主動脈(英语:Abdominal aorta)局部擴大,其橫徑大於3公分或超過正常橫徑之50%[2]。除非腹主動脈瘤破裂,否則通常無症狀[2]。偶爾造成腹部、背部 ... Abdominal aortic aneurysms.. The New England Journal of Medicine. 27 November 2014, 371 (22): 2101-8. PMID 25427112. doi: ... open repair for abdominal aortic aneurysm in patients aged 80 years and older: systematic review and meta-analysis.. European
New research has found that women who smoke are at significantly increased risk of developing an abdominal aortic aneurysm, a ... "Abdominal aortic aneurysm events in the women's health initiative: cohort study". BMJ. 337: a1724. doi:10.1136/bmj.a1724. PMC ... condition in which a weak area of the abdominal aorta expands or bulges, and is the most common form of aortic aneurysm.[156] ...
Fortner G, Johansen K (January 1984). "Abdominal aortic aneurysms". West. J. Med. 140 (1): 50-9. PMC 1011036 . PMID 6702193. ... He is most notable for his method of treatment of aneurysms. He described the types of aneurysms, and created a taxonomy ... His operation for aneurysm remained the standard procedure until the 19th century. Antyllus is also said to have developed a ...
Aortic aneurysm, familial abdominal 1 is a protein that in humans is encoded by the AAA1 gene. "Human PubMed Reference:". " ... "Entrez Gene: Aortic aneurysm, familial abdominal 1". Retrieved 2018-01-18. ...
Recently, one study of the role of genetics in abdominal aortic aneurism (AAA) showed that different BAK1 variants can exist in ... Hatchwell E (Jan 2010). "BAK1 gene variation and abdominal aortic aneurysms-variants are likely due to sequencing of a ... "BAK1 gene variation and abdominal aortic aneurysms". Human Mutation. 30 (7): 1043-7. doi:10.1002/humu.21046. PMID 19514060. ... Michel Eduardo Beleza Yamagishi (2009). "A simpler explanation to BAK1 gene variation in Aortic and Blood tissues". arXiv: ...
In 2001, he treated former presidential candidate Bob Dole who, at age 77, had an abdominal aortic aneurysm; Dr. Ouriel led a ... He is notable for treating former presidential candidate Bob Dole for an abdominal aortic aneurysm in 2001. In the middle 2000s ... The diameter of an abdominal aortic aneurysm ... Kenneth Ouriel, MD, et al., Journal of Vascular Surgery, Volume 37, Issue 6, ... Disparate outcome after endovascular treatment of small versus large abdominal aortic aneurysm, Accessed August 27, 2013, quote ...
Jobko died of an abdominal aortic aneurysm. Bill Jobko, former NFL player and scout, dies at 69. ...
Qi Qian; Kianoush B. Kashani; Dylan V. Miller (10 September 2009). "Ruptured abdominal aortic aneurysm related to IgG4 ... Satomi Kasashima; Yoh Zen (26 January 2011). "IgG4-related Inflammatory Abdominal Aortic Aneurysm, Spectrum of IgG4-related ... "Carotid aneurism with acute dissection: an unusual case of IgG4-related diseases". Cardiovascular Pathology. 25 (1): 59-62. doi ... "Chronic Fibrosing Conditions in Abdominal Imaging". RadioGraphics. Radiological Society of North America. 33 (4): 1053-1080. ...
In addition, ischemic colitis is a well-recognized complication of abdominal aortic aneurysm repair, when the origin of the ... Ischemic colitis after vascular surgery reconstruction of an abdominal aortic aneurysm]". Der Chirurg (in German). 67 (4): 380- ... "Ischemic colitis following repair of ruptured abdominal aortic aneurysm". Archives of Surgery. 120 (12): 1368-70. doi:10.1001/ ... Use during Aortic Aneurysm repair detected when colon oxygen levels fell below sustainable levels, allowing real-time repair. ...
"Relative importance of aneurysm diameter and body size for predicting abdominal aortic aneurysm rupture in men and women." ... 2011). "Resident and fellow experiences after the introduction of endovascular aneurysm repair for abdominal aortic aneurysm". ... "Relative importance of aneurysm diameter and body size for predicting abdominal aortic aneurysm rupture in men and women". J ... "Gender differences in abdominal aortic aneurysm presentation, repair, and mortality in the Vascular Study Group of New England ...
Katz DA, Littenberg B, Cronenwett JL (November 1992). "Management of small abdominal aortic aneurysms. Early surgery vs ... for example abdominal pain) to either improve naturally or become worse. Other examples include: the diagnosis and treatment of ... "Management of asymptomatic aortic stenosis: masterly inactivity but cat-like observation". Heart. 78 (3): 215-7. doi:10.1136/ ...
On 17 April 1955, Einstein experienced internal bleeding caused by the rupture of an abdominal aortic aneurysm, which had ... Cohen, J. R.; Graver, L. M. (November 1995). "The ruptured abdominal aortic aneurysm of Albert Einstein". Surgery, Gynecology ...
It is usually secondary to an abdominal aortic aneurysm repair. Diagnosis is typically via a CT angiography, ...
Doherty died of an abdominal aortic aneurysm at his home in Mississauga, Ontario, on January 19, 2007.[104] He was survived by ...
If that same hypotensive person has back pain instead of a fever, the clinician may see an abdominal aortic aneurysm that is ... Flank pain can indicate obstructing kidney stones or abdominal aortic aneurysm. If obstructing kidney stones are suspected, the ... Emergency department ultrasound scanning for abdominal aortic aneurysm: Accessible, accurate, and advantageous. Ann Emerg Med. ... Abdominal complaints: Abdominal pain is also a common complaint in the primary care and emergency department setting. ...
February 2010). "Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm". The American ... Extracellular granzyme B has been implicated in the pathogenesis of atherosclerosis, aneurysm, vascular leakage, chronic wound ...
However, the scientist was also suffering from an abdominal aortic aneurysm (AAA). An aneurysm is a dilatation that occurs in a ... Nissen wrapped the aneurysm with cellophane and Einstein recovered from the surgery. Upon his hospital discharge, Einstein was ... In 1948, he performed an abdominal surgery that extended the life of Albert Einstein by several years. He trained under German ... In the portion of the aorta that runs through the abdomen, aneurysms are typically asymptomatic until rupture is immiment. AAA ...
On 26 August 2014, Yonekura died of an abdominal aortic aneurysm rupture. He was 80. Zatoichi Meets Yojimbo (1970) Kanashimi no ...
4) Aortic disease: Aortic atherosclerosis, thoracic aortic aneurysm, and abdominal aortic aneurysm. An individual's risk for ... abdominal aortic aneurysm (AAA) diabetes mellitus Chronic Kidney Disease The Framingham/ATP III criteria were used to estimate ...
Two studies of ruptured abdominal aortic aneurysm (AAA) have been carried out. Both demonstrated the weekend effect. In 2012, ... "Effects of weekend admission on the outcomes and management of ruptured aortic aneurysms". J Vasc Surg. 60: 318-24. doi:10.1016 ... "Percutaneous aortic balloon valvotomy in the United States: a 13-year perspective". Am J Med. 127: 744-753.e3. doi:10.1016/j. ... "Higher mortality in patients hospitalized for acute aortic rupture or dissection during weekends". J Vasc Surg. 55: 1247-54. ...
March 28 - Janet Jagan, 88, American-born President of Guyana, abdominal aortic aneurysm. ... August 18 - Hildegard Behrens, 72, German operatic soprano, aortic aneurysm.. *August 19 - Don Hewitt, 86, American television ... November 18 - Jeanne-Claude, 74, French artist, ruptured brain aneurysm.. *November 20 - Ghulam Mustafa Jatoi, 78, Pakistani ... February 4 - Lux Interior, 62, American singer, songwriter and musician, aortic dissection. ...
... for the treatment of abdominal aortic aneurysm, which compared the older open aortic repair technique to the newer endovascular ... October 2009). "Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial". JAMA. 302 (14 ... aneurysm repair device. An example of the latter are clinical trials on mechanical devices used in the management of adult ...
Tierney, DM; Strauss, LP; Sanchez, JL (2006). "Capnocytophaga canimorsus Mycotic Abdominal Aortic Aneurysm: Why the Mailman Is ... Some other signs are abdominal pain, loss of coordination, collapse, or death. Dogs are highly susceptible to theobromine ...
He died in September 2006 while awaiting surgery for an abdominal aortic aneurysm. On 23 January 1989, a group of ... while he was about to be operated of an abdominal aortic aneurysm, on 22 September 2006, at the age of 64. The Politics of ...
Crohn's disease - Gastritis, gallstones, peptic ulcer, abdominal aortic aneurysm, constipation, irritable bowel syndrome, ...
Read the answers to some frequently asked questions on abdominal aortic aneurysm (AAA) screening, including advice about ... This is because aneurysms develop very slowly and it takes a long time to properly assess the full benefits of the screening ... The abdominal scan is only one part of a systematic pathway of care. It would be irresponsible and potentially negligent to ... If youre screened and found to have an aneurysm, this information will need to be shared with a vascular unit so you can get ...
An abdominal aortic aneurysm occurs when an area of the aorta becomes very large or balloons out. ... An abdominal aortic aneurysm is most often seen in males over age 60 who have one or more risk factors. The larger the aneurysm ... When an abdominal aortic aneurysm begins to tear or ruptures, it is a medical emergency. Only about 1 in 5 people survive a ... Abdominal aortic aneurysm. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosens Emergency Medicine: Concepts and Clinical ...
An abdominal aortic aneurysm is when a weak area in the aorta swells up like a balloon. It can cause pain and discomfort if it ... Tags: abdominal aorta, abdominal aortic aneurysm, abdominal pain, Abdominal Pain - Short-term, adult, Aortic Aneurysm, Blood ... This is called an aneurysm. If an aneurysm forms in your abdominal aorta and grows too large, your aorta could tear or burst. ... Abdominal Ultrasound. An abdominal ultrasound is used to diagnose injuries to the abdomen and unexplained abdominal pain. Its ...
... central incision and removal of thrombotic material from the aneurysm. The surgical management of aneurysms however dates back ... Greek surgeon Antyllus tried to treat the aneurysm with proximal and distal ligature, ... Earliest records of abdominal aorta aneurysm in history come from Ancient Rome in the 2nd century AD. ... Earliest records of abdominal aorta aneurysm in history come from Ancient Rome in the 2nd century AD. Greek surgeon Antyllus ...
Abdominal aortic aneurysm and Syphilis. Do You think about Syphilis (lues) as once of causes of aortic aneyrism? (mesaortitis ... Screening for abdominal aortic aneurysm. BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7491.601 (Published 10 March 2005) ...
... usually due to degenerative changes in the aortic wall. There is chronic inflammation of the aortic wall with remodelling of ... A multifactorial disorder in which there is permanent dilation of the abdominal aorta, ... abdominal aortic aneurysm Source:. A Dictionary of Biomedicine. Author(s):. John Lackie. , Brian NationBrian Nation. A ... usually due to degenerative changes in the aortic wall. There is chronic inflammation of the aortic wall with remodelling of ...
Hypertension with dissecting abdominal aortic aneurysm. Br Med J 1974; 4 :23 ... Hypertension with dissecting abdominal aortic aneurysm.. Br Med J 1974; 4 doi: https://doi.org/10.1136/bmj.4.5935.23 (Published ...
Do sex-related differences exist in mortality after repair of ruptured abdominal aortic aneurysm? Is the timeliness of repair a ... Table 1. Baseline Characteristics of Patients Undergoing Repair of Ruptured Abdominal Aortic Aneurysm Total Cohort N (%), N= ... Table 3. Perioperative Complications of Patients Undergoing Repair of Ruptured Abdominal Aortic Aneurysm Total Cohort N (%), N= ... The difficulty in ruptured abdominal aortic aneurysm is that when patients present in extremis, they tend to have rapid ...
This is called an aneurysm. The aorta is the large artery that carries blood to your belly (abdomen), pelvis, ... Open abdominal aortic aneurysm (AAA) repair is surgery to fix a widened part in your aorta. ... Open abdominal aortic aneurysm (AAA) repair is surgery to fix a widened part in your aorta. This is called an aneurysm. The ... Open repair of abdominal aortic aneurysms. In: Cameron JL, Cameron AM, eds. Current Surgical Therapy. 12th ed. Philadelphia, PA ...
Abdominal aortic aneurysm symptoms can be difficult to feel, but can easily be screened for. Learn about this condition and the ... Abdominal Aortic Aneurysm. Abdominal aortic aneurysm is an enlargement of a weak area of your aorta. This type of abdominal ... Diagnosing abdominal aortic aneurysms. If you are at high risk of developing an abdominal aortic aneurysm, or if your doctor ... What Are Abdominal Aortic Aneurysms?. Abdominal aortic aneurysm occurs when the large blood vessel that supplies blood to the ...
... abdominal aortic aneurysm). An abdominal aortic aneurysm is also called AAA or triple A. A thoracic aortic aneurysm refers to ... Abdominal Aortic Aneurysm. What is an abdominal aortic aneurysm?. The aorta is the largest blood vessel in the body. It sends ... What are the symptoms of abdominal aortic aneurysms?. About 3 out of 4 abdominal aortic aneurysms dont cause symptoms. An ... Abdominal aortic aneurysm open repair. A large incision is made in the abdomen to let the surgeon see and repair the aneurysm. ...
Drugs & Diseases , Vascular Surgery , Abdominal Aortic Aneurysm Q&A What are possible causes of an abdominal aortic aneurysm ( ... The management of ruptured abdominal aortic aneurysms: screening for abdominal aortic aneurysm and incidence of rupture. J ... What are possible causes of an abdominal aortic aneurysm (AAA)?) and What are possible causes of an abdominal aortic aneurysm ( ... CT demonstrates abdominal aortic aneurysm (AAA). Aneurysm was noted during workup for back pain, and CT was ordered after AAA ...
If abdominal aortic aneurysm (AAA) isnt found and treated early, it can be deadly. Share this resource to encourage men age 65 ... for abdominal aortic aneurysm (AAA).. Am I at risk for AAA?. Men over age 65 who have smoked at any point in their lives have ... Home , Health Topics A to Z , Health Conditions and Diseases , Heart Health , Talk to Your Doctor about Abdominal Aortic ... This balloon-like swelling is called an aneurysm ("AN-yoor-izm"). AAA is an aneurysm that occurs in the part of the aorta ...
... thus excluding the abdominal aortic aneurysm from circulation.. History: Endovascular grafting of abdominal aneurysms, first ... In addition to being used for abdominal aortic aneurysm repair, stent grafts have been used to repair isolated iliac aneurysms ... Technology: Endovascular abdominal aortic aneurysm repair. Use: The tremendous enthusiasm within the international vascular ... Feasibility of endovascular repair of abdominal aortic aneurysms with local anesthesia with intravenous sedation. J Vasc Surg ...
Chao Zhang, Dustin van der Voort, Hong Shi, Rongli Zhang, Yulan Qing, Shuichi Hiraoka, Minoru Takemoto, Koutaro Yokote, Joseph V. Moxon, Paul Norman, Laure Rittié, Helena Kuivaniemi, G. Brandon Atkins, Stanton L. Gerson, Guo-Ping Shi, Jonathan Golledge, Nianguo Dong, Bernard Perbal, Domenick A. Prosdocimo, Zhiyong Lin. ...
The most common location of an abdominal aortic aneurysm is located below the kidney arteries, called an intrarenal AAA. A ... occurs when a weakened area in the wall of the abdominal aorta bulges or expands. The aorta is the major blood vessel that ... An abdominal aortic aneurysm, also known as AAA, ... Abdominal Aortic Aneurysm An abdominal aortic aneurysm, also ... A ruptured abdominal aortic aneurysm can cause life-threatening bleeding. An aneurysm can be characterized by its location, ...
... the wall of the aorta in the stomach weakens and expands to form an abdominal aortic aneurysm. Screening can detect an aneurysm ... Abdominal aortic aneurysm screening. * Abdominal aortic aneurysm screening - getting screened * Abdominal aortic aneurysm ... Abdominal aortic aneurysm (AAA). Most people with an AAA dont have any symptoms. To read more about an AAA, go to:. *Abdominal ... By screening, it is possible to detect, monitor and treat most abdominal aortic aneurysms. This reduces the risk of an aneurysm ...
... Topic Overview. Abdominal aortic aneurysms can be found during an ultrasound screening ... Abdominal Aortic Aneurysm: Should I Get a Screening Test?. For men. Your doctor may recommend a screening test if you are a man ... Some say men as young as 55 should be screened if they have a family history of abdominal aortic aneurysm.footnote 3 ... 2009). Care of patients with an abdominal aortic aneurysm: Society for Vascular Surgery practice guidelines. Journal of ...
The most typical manifestation of rupture is abdominal or back pain with a pulsatile abdominal mass. However, the symptoms may ... The management of ruptured abdominal aortic aneurysms: screening for abdominal aortic aneurysm and incidence of rupture. J ... Drugs & Diseases , Vascular Surgery , Abdominal Aortic Aneurysm Q&A What are the symptoms of a ruptured abdominal aortic ... CT demonstrates abdominal aortic aneurysm (AAA). Aneurysm was noted during workup for back pain, and CT was ordered after AAA ...
The management of ruptured abdominal aortic aneurysms: screening for abdominal aortic aneurysm and incidence of rupture. J ... Abdominal Aortic Aneurysm Q&A What specialist consultations should are needed for abdominal aortic aneurysm (AAA)?. Updated: ... CT demonstrates abdominal aortic aneurysm (AAA). Aneurysm was noted during workup for back pain, and CT was ordered after AAA ... Endovascular versus open repair of abdominal aortic aneurysm in 15-years follow-up of the UK endovascular aneurysm repair ...
... and method and apparatus for repairing an abdominal aortic aneurysm includes a tubular graft which is intraluminally delivered ... 9-12, a method for repairing an abdominal aortic aneurysm 151 and iliac aneurysm 190 with an aortic graft 150 as illustrated ... "aortic aneurysm" in this specification and claims is intended to relate to and mean both abdominal aortic aneurysms and ... and a method and apparatus for repairing an abdominal aortic aneurysm.. DESCRIPTION OF THE PRIOR ART. An abdominal aortic ...
Medicare will cover abdominal aortic aneurysm (AAA) screening in at-risk beneficiaries for 12 months after enrollment, a ... According to the society, about 200,000 patients in the U.S. are diagnosed with abdominal aortic aneurysm each year, and about ... 22 -- Medicare has doubled the time for new beneficiaries to take advantage of screening for abdominal aortic aneurysm. That ... An estimated one million patients are living with undiagnosed abdominal aortic aneurism, and 95% of them can be treated if ...
15,000 deaths per year are attributed to abdominal aortic aneurysms (AAAs). Abdominal aortic aneurysms occur most commonly in ... encoded search term (Abdominal Aortic Aneurysm Imaging) and Abdominal Aortic Aneurysm Imaging What to Read Next on Medscape. ... In the United States, 15,000 deaths per year are attributed to abdominal aortic aneurysms (AAAs). Abdominal aortic aneurysms ... abdominal aortic aneurysm screening center in the context of optimizing United Kingdom National Abdominal Aortic Aneurysm ...
Search of: Abdominal aortic aneurysm - Modify Search. Fill in any or all of the fields below. Click on the label to the left ...
Psoriasis and abdominal aortic aneurysms. In the general population, abdominal aortic aneurysms occur at a rate of 3.72 cases ... In general, abdominal aortic aneurysms have no symptoms as they slowly swell over a number of years. Some of the major causes ... When an abdominal aortic aneurysm ruptures, often with little warning, it becomes a medical emergency and can be fatal. Because ... MedlinePlus, Abdominal aortic aneurysm, accessed 14 April 2016. National Psoriasis Foundation, Causes and triggers, Why Does ...
  • We report a case of a sixty year old man with a mycotic infra-renal abdominal aortic aneurysm complicated by a left psoas abscess. (biomedsearch.com)
  • A number of techniques exist for maintaining perfusion to the viscera and spinal cord during open thoracoabdominal aortic aneurysm repair, including left heart bypass, balloon perfusion catheter placement in the visceral arteries, selective spinal drainage and cold crystalloid renal perfusion. (wikipedia.org)
  • The majority of abdominal and pelvic CT's can be performed using a single-phase, but the evaluation of some tumor types (hepatic/pancreatic/renal), the urinary collecting system, and trauma patients among others, may be best performed with multiple phases. (wikipedia.org)
  • Acute loin pain Haematuria Ballotable kidneys Sub arachnoid hemorrhage(berry aneurysm) Hypertension Associated liver cyst Uremia due to renal failure Anemia due to CKD Increase RBC or erythropoeitin secretion In many patients with ADPKD, kidney dysfunction is not clinically apparent until forty or fifty years of life. (wikipedia.org)
  • The recommended treatment option will depend on the size of the aneurysm. (tgh.org)
  • blood clots may form at the site and dislodge, increasing the chance of stroke Increase in the size of the aneurysm, causing it to press on other organs, which may cause pain. (wikipedia.org)
  • Indication for surgery may depend upon the size of the aneurysm. (wikipedia.org)
  • There is chronic inflammation of the aortic wall with remodelling of the extracellular matrix, and depletion of vascular smooth muscle cells. (oxfordreference.com)
  • Studies in mouse models of aneurysm showed that that this tracer allows for imaging vessel wall biology with high sensitivity and specificity, and aortic tracer uptake in vivo correlates with vessel wall inflammation," explains Mehran M. Sadeghi, MD, of the Yale Cardiovascular Research Center in New Haven and the West Haven VA Medical Center in West Haven, Connecticut. (eurekalert.org)
  • Alcohol and hypertension: The inflammation caused by prolonged use of alcohol and hypertensive effects from abdominal edema which leads to hemorrhoids, esophageal varices, and other conditions, is also considered a long-term cause of AAA. (wikipedia.org)
  • Cyclic pressurization of segmentally stiffened aortic segments ex vivo increases the expression of genes related to inflammation and extracellular matrix (ECM) remodeling. (ahajournals.org)
  • The characteristic pathology of an aneurysm is characterized by progressive vessel wall dilation, promoted by dying vascular smooth muscle cells and limited proliferation, as well as impaired synthesis and degradation of extracellular matrix components, which at least partially is the result of transmural inflammation and its disruptive effect on vessel wall homeostasis. (nih.gov)
  • The researchers found the neutrophils that gather at the site of aortic injury send out a distress call in the form of a chemical, CXCL2, which sustains the inflammation by sending even more neutrophils to the aortic wall. (news-medical.net)
  • Z. Qu, Bernice L. Y. Cheuk, and Stephen W. K. Cheng, "Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms," Mediators of Inflammation , vol. 2012, Article ID 643609, 7 pages, 2012. (hindawi.com)
  • In rare cases, abdominal aortic aneurysm may be caused by an infection or inflammation that weakens a section of the aortic wall. (wikipedia.org)
  • This inflammation is what gives IAA the characteristic thickened walls of the aneurysm. (wikipedia.org)
  • Severe complications of a ruptured appendix include widespread, painful inflammation of the inner lining of the abdominal wall and sepsis. (wikipedia.org)
  • Specific infective causes associated with aneurysm include: Advanced syphilis infection resulting in syphilitic aortitis and an aortic aneurysm Tuberculosis, causing Rasmussen's aneurysms Brain infections, causing infectious intracranial aneurysms A minority of aneurysms are associated with genetic factors. (wikipedia.org)
  • Neurosurgeons and interventional neuroradiologists surgically manage diseases of the vessels in the brain (e.g., intracranial aneurysms). (wikipedia.org)
  • His actual emphasis covers the development of interventional procedures for children, aortic stent grafts and the diagnostics and therapy of congenital vascular anomalies. (wikipedia.org)
  • It is therefore important that cardiologists acquire a sufficient knowledge base so that they can confidently evaluate and manage patients with aortic disease and know when it is appropriate to refer them for surgery. (ahajournals.org)