Aorta: The main trunk of the systemic arteries.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Aortic Diseases: Pathological processes involving any part of the AORTA.Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Aortitis: Inflammation of the wall of the AORTA.Aneurysm, Infected: Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.ElastinAtherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Polyethylene Terephthalates: Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.Arteries: The vessels carrying blood away from the heart.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Dilatation, Pathologic: The condition of an anatomical structure's being dilated beyond normal dimensions.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Diet, Atherogenic: A diet that contributes to the development and acceleration of ATHEROGENESIS.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Venae Cavae: The inferior and superior venae cavae.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Rats, Inbred WKY: A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Rats, Inbred SHR: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Cholesterol, Dietary: Cholesterol present in food, especially in animal products.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Nitroprusside: A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Echocardiography, Transesophageal: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Takayasu Arteritis: A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Elasticity: Resistance and recovery from distortion of shape.Subclavian Artery: Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Constriction: The act of constricting.Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Mesenteric Arteries: Arteries which arise from the abdominal aorta and distribute to most of the intestines.Elastic Tissue: Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.Brachiocephalic Trunk: The first and largest artery branching from the aortic arch. It distributes blood to the right side of the head and neck and to the right arm.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mice, Inbred C57BLCalcinosis: Pathologic deposition of calcium salts in tissues.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Aortic Arch Syndromes: Conditions resulting from abnormalities in the arteries branching from the ASCENDING AORTA, the curved portion of the aorta. These syndromes are results of occlusion or abnormal blood flow to the head-neck or arm region leading to neurological defects and weakness in an arm. These syndromes are associated with vascular malformations; ATHEROSCLEROSIS; TRAUMA; and blood clots.Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Carotid Arteries: Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Celiac Artery: The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.Myocytes, Smooth Muscle: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Angiography: Radiography of blood vessels after injection of a contrast medium.Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.Pulsatile Flow: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.Ductus Arteriosus: A fetal blood vessel connecting the pulmonary artery with the descending aorta.Circulatory Arrest, Deep Hypothermia Induced: A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Spinal Cord Ischemia: Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.Thoracotomy: Surgical incision into the chest wall.Desmosine: A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Receptors, Thromboxane: Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.Magnetic Resonance Angiography: Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.Coronary Vessels: The veins and arteries of the HEART.Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.Tunica Media: The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.Sinus of Valsalva: The dilatation of the aortic wall behind each of the cusps of the aortic valve.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Mesenteric Artery, Superior: A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Epoprostenol: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).Vena Cava, Inferior: The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)Czechoslovakia: Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.

Reduction in baroreflex cardiovascular responses due to venous infusion in the rabbit. (1/10763)

We studied reflex bradycardia and depression of mean arterial blood pressure (MAP) during left aortic nerve (LAN) stimulation before and after volume infusion in the anesthetized rabbit. Step increases in mean right atrial pressure (MRAP) to 10 mm Hg did not result in a significant change in heart rate or MAP. After volume loading, responses to LAN stimulation were not as great and the degree of attenuation was propoetional to the level of increased MRAP. A change in responsiveness was observed after elevation of MRAP by only 1 mm Hg, corresponding to less than a 10% increase in average calculated blood volume. after an increase in MRAP of 10 mm Hg, peak responses were attenuated by 44% (heart rate) and 52% (MAP), and the initial slopes (rate of change) were reduced by 46% (heart rate) and 66% (MAP). Comparison of the responses after infusion with blood and dextran solutions indicated that hemodilution was an unlikely explanation for the attenuation of the reflex responses. Total arterial baroreceptor denervation (ABD) abolished the volume-related attenuation was still present following bilateral aortic nerve section or vagotomy. It thus appears that the carotid sinus responds to changes inblood volume and influences the reflex cardiovascular responses to afferent stimulation of the LAN. On the other hand, cardiopulmonary receptors subserved by vagal afferents do not appear to be involved.  (+info)

Quantification of baroreceptor influence on arterial pressure changes seen in primary angiotension-induced hypertension in dogs. (2/10763)

We studied the role of the sino-aortic baroreceptors in the gradual development of hypertension induced by prolonged administration of small amounts of angiotensin II (A II) in intact dogs and dogs with denervated sino-aortic baroreceptors. Short-term 1-hour infusions of A II(1.0-100 ng/kg per min) showed that conscious denervated dogs had twice the pressor sensitivity of intact dogs. Long-term infusions of A II at 5.0 ng/kg per min (2-3 weeks) with continuous 24-hour recordings of arterial pressure showed that intact dogs required 28 hours to reach the same level of pressure attained by denervated dogs during the 1st hour of infusion. At the 28th hour the pressure in both groups was 70% of the maximum value attained by the 7th day of infusion. Both intact and denervated dogs reached nearly the same plateau level of pressure, the magnitude being directly related both the the A II infusion rate and the daily sodium intake. Cardiac output in intact dogs initially decreased after the onset of A II infusion, but by the 5th day of infusion it was 38% above control, whereas blood volume was unchanged. Heart rate returned to normal after a reduction during the 1st day of infusion in intact dogs. Plasma renin activity could not be detected after 24 hours of A II infusion in either intact or denervated dogs. The data indicate that about 35% of the hypertensive effect of A II results from its acute pressor action, and an additional 35% of the gradual increase in arterial pressure is in large measure a result of baroreceptor resetting. We conclude that the final 30% increase in pressure seems to result from increased cardiac output, the cause of which may be decreased vascular compliance. since the blood volume remains unaltered.  (+info)

Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. (3/10763)

Atherosclerotic lesion development is characterized by the recruitment of leukocytes, principally monocytes, to the vessel wall. Considerable interest has been focused on the adhesion molecule(s) involved in leukocyte/endothelial interactions. The goal of the present study was to determine the role of the very late antigen-4 (VLA-4) integrin/ligand interaction in fatty streak development using murine models. Because alpha4 null mice are not viable, a peptidomimetic was used to block VLA-4-mediated leukocyte binding. The ability of a synthetic peptidomimetic of connecting segment-1 (CS-1 peptide) to block the recruitment of leukocytes and the accumulation of lipid in the aortic sinus of either wild-type mice (strain C57BL/6J) or mice with a low-density lipoprotein null mutation (LDLR-/-) maintained on an atherogenic diet was assessed. The active (Ac) CS-1 peptide or scrambled (Sc) CS-1 peptide was delivered subcutaneously into mice using a mini osmotic pump. Mice were exposed to the peptide for 24 to 36 hours before the onset of the atherogenic diet. In C57BL/6J mice, leukocyte entry into the aortic sinus, as assessed by en face preparations, was inhibited by the active peptide (Ac=28+/-4, Sc=54+/-6 monocytes/valve; P=0.004). Additionally, frozen sections stained with Oil Red O were analyzed to assess lipid accumulation in the aortic sinus. C57BL/6J mice that received the (Ac) compound demonstrated significantly reduced lesion areas as compared with mice that received the (Sc) peptide (Ac=4887+/-4438 microm2, Sc=15 009 +/-5619 microm2; P<0.0001). In a separate study, LDLR-/- mice were implanted with pumps containing either the (Ac) or (Sc) peptide before initiation of the atherogenic diet. Because LDLR-/- mice fed a chow diet displayed small lesions at 14 weeks, the effects of the peptide seen in these animals represented a change in early lipid accumulation rather than initiation. By using whole-mount preparations, the (Ac) but not the (Sc) peptide significantly reduced the area of lipid accumulation in the aortic sinus, resulting in an approximate 66% decrease. Plasma analysis from all studies revealed concentrations of peptide to be present at levels previously determined by in vitro analysis to block adhesion. (Ac) CS-1 peptide, which blocks VLA-4 on the leukocyte surface, is effective in reducing leukocyte recruitment and lipid accumulation in the aortic sinus. The present study provides in vivo evidence that the VLA-4 integrin plays an important role in the initiation of the atherosclerotic lesion and lipid accumulation, and it suggests a potential therapeutic strategy for this disease.  (+info)

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (4/10763)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney.  (+info)

Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats. (5/10763)

We investigated the involvement of actions mediated by endothelin-A (ETA) and endothelin-B (ETB) receptors in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt-induced hypertension in rats. Two weeks after the start of DOCA-salt treatment, rats were given ABT-627 (10 [mg/kg]/d), a selective ETA receptor antagonist; A-192621 (30 [mg/kg]/d), a selective ETB receptor antagonist; or their vehicle for 2 weeks. Uninephrectomized rats without DOCA-salt treatment served as controls. Treatment with DOCA and salt for 2 weeks led to a mild but significant hypertension; in vehicle-treated DOCA-salt rats, systolic blood pressure increased markedly after 3 to 4 weeks. Daily administration of ABT-627 for 2 weeks almost abolished any further increases in blood pressure, whereas A-192621 did not affect the development of DOCA-salt-induced hypertension. When the degree of vascular hypertrophy of the aorta was histochemically evaluated at 4 weeks, there were significant increases in wall thickness, wall area, and wall-to-lumen ratio in vehicle-treated DOCA-salt rats compared with uninephrectomized control rats. The development of vascular hypertrophy was markedly suppressed by ABT-627. In contrast, treatment with A-192621 significantly exaggerated these vascular changes. In vehicle-treated DOCA-salt rats, renal blood flow and creatinine clearance decreased, and urinary excretion of protein, blood urea nitrogen, fractional excretion of sodium, and urinary N-acetyl-beta-glucosaminidase activity increased. Such damage was overcome by treatment with ABT-627 but not with A-192621; indeed, the latter agent led to worsening of the renal dysfunction. Histopathologic examination of the kidney in vehicle-treated DOCA-salt rats revealed tubular dilatation and atrophy as well as thickening of small arteries. Such damage was reduced in animals given ABT-627, whereas more severe histopathologic changes were observed in A-192621-treated animals. These results strongly support the view that ETA receptor-mediated action plays an important role in the pathogenesis of DOCA-salt-induced hypertension. On the other hand, it seems likely that the ETB receptor-mediated action protects against vascular and renal injuries in this model of hypertension. A selective ETA receptor antagonist is likely to be useful for treatment of subjects with mineralocorticoid-dependent hypertension, whereas ETB-selective antagonism alone is detrimental to such cases.  (+info)

AMP-activated protein kinase phosphorylation of endothelial NO synthase. (6/10763)

The AMP-activated protein kinase (AMPK) in rat skeletal and cardiac muscle is activated by vigorous exercise and ischaemic stress. Under these conditions AMPK phosphorylates and inhibits acetyl-coenzyme A carboxylase causing increased oxidation of fatty acids. Here we show that AMPK co-immunoprecipitates with cardiac endothelial NO synthase (eNOS) and phosphorylates Ser-1177 in the presence of Ca2+-calmodulin (CaM) to activate eNOS both in vitro and during ischaemia in rat hearts. In the absence of Ca2+-calmodulin, AMPK also phosphorylates eNOS at Thr-495 in the CaM-binding sequence, resulting in inhibition of eNOS activity but Thr-495 phosphorylation is unchanged during ischaemia. Phosphorylation of eNOS by the AMPK in endothelial cells and myocytes provides a further regulatory link between metabolic stress and cardiovascular function.  (+info)

RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. (7/10763)

The human MAT1 gene (menage a trois 1) is an assembly factor and a targeting subunit of cyclin-dependent kinase (CDK)-activating kinase. The novel mechanisms by which MAT1 forms an active CDK-activating kinase and determines substrate specificity of CDK7-cyclin H are involved in the cell cycle, DNA repair, and transcription. Hyperplasia of vascular smooth muscle cells (SMC) is a fundamental pathologic feature of luminal narrowing in vascular occlusive diseases, and nothing is yet known regarding the cell cycle phase specificity of the MAT1 gene in its involvement in SMC proliferation. To investigate such novel regulatory pathways, MAT1 expression was abrogated by retrovirus-mediated gene transfer of antisense MAT1 RNA in cultured rat aortic SMCs. We show that abrogation of MAT1 expression retards SMC proliferation and inhibits cell activation from a nonproliferative state. Furthermore, we have demonstrated that these effects are due to G1 phase arrest and apoptotic cell death. Our studies indicate a link between cell cycle control and apoptosis and reveal a potential mechanism for coupling the regulation of MAT1 with G1 exit and prevention of apoptosis.  (+info)

Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. (8/10763)

OBJECTIVE: To determine whether increased plasma concentrations of endothelin-1 (ET-1) and big endothelin (BET) play a role in the regulation of coronary circulation in patients with idiopathic dilated cardiomyopathy (IDCM). SETTING: Tertiary referral centre for cardiac diseases. PATIENTS: Fourteen patients (eight male/six female; mean (SD) age 59 (9) years) with IDCM (ejection fraction 36 (9)%) and five normotensive subjects (two male/three female; age 52 (7) years) serving as controls were studied. METHODS: Functional status was classified according to New York Heart Association (NYHA) class. Endogenous ET-1 and BET plasma concentrations from the aorta and the coronary sinus were determined by radioimmunoassay. Coronary blood flow, using the inert chromatographic argon method, myocardial oxygen consumption, and coronary sinus oxygen content under basal conditions were determined. RESULTS: In the aorta, mean (SD) concentrations of ET-1 (IDCM 0.76 (0.25) v controls 0.31 (0.06) fmol/ml; p = 0.002) and BET (IDCM 3.58 (1.06) v controls 2.11 (0.58) fmol/ml; p = 0.014) were increased in patients with IDCM. Aortic ET-1 concentrations correlated positively with NYHA class (r = 0. 731; p < 0.001), myocardial oxygen consumption (r = 0.749; p < 0. 001), and coronary blood flow (r = 0.645; p = 0.003), but inversely with coronary sinus oxygen content (r = -0.633; p = 0.004), which was significantly decreased in IDCM patients (IDCM 4.68 (1.05) v controls 6.70 (1.06) vol%; p = 0.003). CONCLUSIONS: The coronary circulation in patients with IDCM is exposed to an increased endothelin load. ET-1 concentrations correlate with functional deterioration. A decrease of the coronary sinus content of oxygen suggests a mismatch between coronary blood flow and metabolic demand. Thus, ET-1 might be a marker of a disequilibrium between myocardial oxygen demand and coronary blood flow in IDCM.  (+info)

*Arterial tree

Thoracic aorta[edit]. This section needs expansion. You can help by adding to it. (October 2007) ... Abdominal aorta[edit]. inferior phrenic[edit]. celiac[edit]. *left gastric artery *hepatic branch ... left common carotid artery (directly from arch of aorta on left mostly)[edit]. internal carotid artery[edit]. *ophthalmic ... Left subclavian artery (directly from arch of aorta on left)[edit]. vertebral artery[edit]. *Meningeal branches of vertebral ...

*Blood vessel

Left heart → Aorta → Arteries → Arterioles → Capillaries → Venules → Veins → Vena cava → (Right heart) ...


It is normally less than 10 mm Hg,[26] but may be increased in e.g. coarctation of the aorta.[26] ... Blood being pumped out of the heart first enters the aorta, the largest artery of the body. It then proceeds to divide into ... the right subclavian artery averages 120/80 and the abdominal aorta is 110/70 mmHg.[18] The relatively uniform pressure in the ... arm-leg blood pressure gradient and abnormal arterial compliance in patients with repaired coarctation of the aorta". Am. J. ...

*Australian Dance Awards

Aorta Choreographed by Stephanie Lake Outstanding Performance by a Company The Australian Ballet Cinderella ...

*Pericardiacophrenic artery

The thoracic aorta, viewed from the left side. (Pericardiacophrenic labeled at center left.) ...


"aorta food.. *^ Larson, Tevy (25 February 2013). "Chicken Rice Congee (Khmer Borbor Sach Mouan)". Tevys Food Blog. blogspot.. ...

*Renal artery

Due to the position of the aorta, the inferior vena cava, and the kidneys in the body, the right renal artery is normally ... The renal arteries normally arise off the left interior side of the abdominal aorta, immediately below the superior mesenteric ... One or two accessory renal arteries are frequently found, especially on the left side since they usually arise from the aorta, ... Anatomy photo:40:11-0105 at the SUNY Downstate Medical Center - "Posterior Abdominal Wall: Branches of the Abdominal Aorta" ...

*Short gastric arteries

The short gastric arteries consist of from five to seven small branches, which arise from the end of the splenic artery, and from its terminal divisions. They pass from left to right, between the layers of the gastrolienal ligament, and are distributed to the greater curvature of the stomach, anastomosing with branches of the left gastric and left gastroepiploic arteries. Unlike the gastroepiploics and the left and right gastric arteries, the short gastric arteries have poor anastomoses if the splenic artery is blocked. ...

*Supraduodenal artery

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*Bird anatomy

Both hearts are labeled with the following parts: 1. Ascending Aorta 2. Left Atrium 3. Left Ventricle 4. Right Ventricle 5. ...

*Urinary system

Abdominal aorta, 11. Common iliac artery and vein. Transparent: 12. Liver, 13. Large intestine, 14. Pelvis ...

*Bird anatomy

Both hearts are labeled with the following parts: 1. Ascending Aorta 2. Left Atrium 3. Left Ventricle 4. Right Ventricle 5. ...

*Bird anatomy

Both hearts are labeled with the following parts: 1. Ascending Aorta 2. Left Atrium 3. Left Ventricle 4. Right Ventricle 5. ...

*Urinary bladder

Abdominal aorta, 11. Common iliac artery and vein. With transparency: 12. Liver, 13. Large intestine, 14. Pelvis ...

*Артериално дърво - Уикипедия

Възходяща аорта (aorta ascendens)[редактиране , редактиране на кода]. Дясна коронарна артерия (a. coronaria dextra)[редактиране ... Коремна аорта (aorta abdominalis)[редактиране , редактиране на кода]. Чревен ствол (truncus coeliacus)[редактиране , ... 4 Коремна аорта (aorta abdominalis) *4.1 Чревен ствол (truncus coeliacus). *4.2 Горна опорачна артерия (a. mesenterica superior ... Аортна дъга (arcus aortae)[редактиране , редактиране на кода]. Мишничноглавов ствол (truncus brachiocephalicus)[редактиране , ...

*Congenital heart defect

A failure may result in some blood flowing into the wrong vessel (e.g.overriding aorta). The four-chambered heart and the great ... A small vessel, the ductus arteriosus allows blood from the pulmonary artery to pass to the aorta.[26] ... Coarctation of the aorta (CoA). *Double aortic arch, aberrant subclavian artery, and other malformations of the great arteries ... Common defects include pulmonic stenosis, aortic stenosis, and coarctation of the aorta, with other types such as bicuspid ...

*Traumatic aortic rupture

The aorta may also be torn at the point where it is connected to the heart. The aorta may be completely torn away from the ... Though there is a concern that a small, stable tear in the aorta could enlarge and cause complete rupture of the aorta and ... the aorta can be assessed by a CT angiogram or a direct angiogram, in which contrast is introduced into the aorta via a ... near where the left subclavian artery branches off from the aorta.[7] The tethering of the aorta by the ligamentum arteriosum ...

*Aortic valve

pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... The aortic valve is a valve in the human heart between the left ventricle and the aorta. It is one of the two semilunar valves ... When the pressure in the left ventricle rises above the pressure in the aorta, the aortic valve opens, allowing blood to exit ... Common causes of aortic regurgitation include vasodilation of the aorta, previous rheumatic fever, infection such as infective ...


"Soluble elastin decreases in the progress of atheroma formation in human aorta". Circulation Journal. 73 (11): 2154-62. doi: ... for pressure wave propagation to help blood flow and is particularly abundant in large elastic blood vessels such as the aorta ...


"Soluble elastin decreases in the progress of atheroma formation in human aorta". Circulation Journal. 73 (11): 2154-62. doi: ... for pressure wave propagation to help blood flow and is particularly abundant in large elastic blood vessels such as the aorta ...

*Small intestine

These are both branches of the aorta. The duodenum receives blood from the coeliac trunk via the superior pancreaticoduodenal ...

*Secondary hypertension

Malformed aorta, slow pulse, ischemia: these cause reduced blood flow to the renal arteries, with physiological responses as ...

*Necrotizing vasculitis

bruit over one or both carotid arteries or abdominal aorta. *arteriographic narrowing of aorta, its primary branches, or large ... Primarily affects the aorta and its main branches. At least 3 out of 6 criteria yields sensitivity and specificity of 90.5 and ... However, in Takayasu's arteritis, where the aorta may be involved, it is unlikely a biopsy will be successful and angiography ...

*Blalock-Taussig shunt

left ventricle to aorta Rastelli procedure. right ventricle to pulmonary artery Sano shunt. compound procedures. for ... The arch of the aorta and its branches. In the Blalock-Thomas-Taussig shunt, blood from the subclavian artery or carotid artery ...

*Blood pressure

The blood pressure in the fetal aorta is approximately 30 mmHg at 20 weeks of gestation, and increases to approximately 45 mmHg ... "Blood pressure estimation in the human fetal descending aorta". Ultrasound Obstet Gynecol. 32 (5): 673-81. doi:10.1002/uog.6137 ... of the arterial system-largely attributable to the aorta and large elastic arteries-and the resistance to flow in the arterial ...

*Traditional English pronunciation of Latin

In specialized anatomical vocabulary: aorta, biceps, cranium, patella, penis, sinus, vertebra, vagina, etc. ...
The SphygmoCor® CP System The SphygmoCor CP system includes pulse wave analysis (PWA) software only. During a PWA measurement, a 10-second snapshot of the radial arterial pressure wave is measured using a tonometer. The SphygmoCor software derives the ascending aortic pressure wave, substantially equivalent to the pressure wave measured by an invasive catheter. From the aortic pressure wave, a number of valuable cardiovascular measurements are determined, including central aortic systolic pressure, aortic augmentation index and central pulse pressure ...
In the present study, we addressed 2 questions that are pertinent to vascular aging. First, we determined whether aging is associated with the lengthening or elongation of the aorta and large conduit arteries. We found that the length of the ascending aorta increased significantly with advancing age, whereas the descending aorta did not demonstrate age-associated lengthening. The age-related elongation of the ascending aorta was associated with the corresponding increase in central arterial stiffness and pulse wave amplification, suggesting that the reduction in the elastic property as well as local pulsatile pressure might play a causative role. Second, we determined what impact the aortic elongation has on PWV, which is 1 of the most established measures of arterial stiffness. We found that age-related aortic elongation has little impact on PWV measurement because the segment of the ascending aorta is omitted from the arterial length measurements for carotid-femoral PWV. Moreover, the most ...
Fluid flow induced significant increases in the FGF-2 content in the circulating medium and in the pericellular region. At a shear stress level of 25 dyne/cm2, there was a 1.5-fold increase in the pericellular FGF-2 content, which represents release of 15% of the total FGF-2 in the cell (Figure 4⇑). The release was rapid in view of the fact that it occurred at ≤15 minutes and thus did not depend on the de novo synthesis of FGF-2. This release was not sustained, as seen by the decay in medium levels with time (Figure 1⇑), which can be explained by the adsorption of FGF-2 to the surfaces of the experimental system. The half-life of FGF-2 in the flow system (Figure 2⇑) is ≈4 hours. This means that FGF-2 will adsorb to surfaces after prolonged contact, and data points beyond 4 hours represent significant loss due to this adsorption. Because the release response found in the present study was rapid, adsorption did not represent a significant loss in the first 15 minutes. Furthermore, FGF-2 ...
The aorta is a large artery with a thick wall. This is necessary for it to handle a large volume of blood exiting the heart and contend with high pressure. However, there are several reasons why the inner lining of the wall can be compromised. This can cause the inner lining to tear. The blood under high pressure may then enter the wall of the aorta and create a channel for the blood between the inner and middle layer.. It is more likely to occur if the blood pressure rises to levels that are too high. Another factor is that wall of the aorta may be weakened. However, in most cases the blood may not extend beyond the middle layer of the aortic wall. Fortunately this middle layer is significantly strong to withstand the high pressure for a period of time. Eventually the blood can penetrate through the middle layer and lead to a rupture of the aorta.. Blood may then pour out of the aorta from where it bursts. As a result the blood pressure cannot be maintained at normal levels and oxygen-rich ...
enlarged aorta - MedHelps enlarged aorta Center for Information, Symptoms, Resources, Treatments and Tools for enlarged aorta. Find enlarged aorta information, treatments for enlarged aorta and enlarged aorta symptoms.
Penyakit Aneurisma Aorta - Aneurisma aorta atau aneurisme aorta merupakan pembengkakan pembuluh aorta perut atau pembesaran aorta, pembuluh darah utama yang menyalurkan darah ke tubuh pada level abdomen. Baca Juga [more…] ...
Aims - Aortic adaptive immunity plays a crucial role in atherosclerosis; however, the precise mechanisms leading to T cell activation in the arterial wall remain poorly understood. Methods and Results - Here we have identified naïve T cells in the aorta of wild-type and TCR transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with a similar activation profile to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in part by the P-selectin glycosylated ligand-1 (PSGL-1) receptor. In experimental atherosclerosis the aorta supports CD4+ T cell activation selectively driving Th1 polarization. By contrast, secondary lymphoid organs display Treg expansion. Conclusions - Our results demonstrate that the aorta can support T cell priming and that naïve T cells traffic between the circulation and vessel wall. These data underpin the paradigm that local priming of T cells specific for plaque antigens contributes to atherosclerosis
A method and device for occluding a patients ascending aorta, maintaining circulation of oxygenated blood in the patient and delivering cardioplegic fluid to arrest the patients heart. An aortic occlusion catheter has an occluding member for occluding the ascending aorta. The aortic occlusion catheter passes through a cannula. Delivery of oxygenated blood is accomplished through either the cannula or the aortic occlusion catheter.
Enlargement of the ascending aorta indicates a weakening of the aortic wall, according to Cedars-Sinai. Often, an enlarged ascending aorta is diagnosed as an aneurysm....
MicroRNAs have been demonstrated to be involved in the development of atherosclerosis. The present study aimed to evaluate the effect of miR-99a-5p and its target gene Homeobox A1 (HOXA1) in atherosclerosis.The biological functions of miR-99a-5p on human aortic smooth muscle cells (ASMCs) were assessed by MTT, wound healing and transwell assays. The target genes of microRNAs were predicted by Targ ...
noun the descending part of the aorta that branches into the thoracic and abdominal aortae • Hypernyms: ↑aorta * * * noun : the part of the aorta from the arch to its bifurcation that passes downward in the thoracic and abdominal cavities
ATCC offers cell lines derived from the normal aorta of human, mouse and rat, as well as primary aortic smooth muscle cells from human.
ATCC offers cell lines derived from the normal aorta of human, mouse and rat, as well as primary aortic smooth muscle cells from human.
TY - JOUR. T1 - Non-invasive assessment of wave reflection phenomena in the central aorta. AU - Avolio, Alberto. AU - Cook, David. AU - Old, R. AU - Halliday, A. PY - 2002. Y1 - 2002. M3 - Conference paper. SP - 895. EP - 895. JO - Journal of Hypertension. T2 - Journal of Hypertension. JF - Journal of Hypertension. SN - 1473-5598. ER - ...
Presented in this paper are 3 cases of hemorrhage of ascending aorta and left ventricle after open heart surgery treated by extracardial bypass in our hospital from Oct. 1994 to Dec. 1995. Remained aneurysmal wall enclosing conduit graft was used as
Individual evaluation of each patient, and each aorta, is key to durable repair. "The instructions for use (IFU) are not a clinical guideline, so trainees should really think about what the main considerations are when they are implanting devices in the aorta to create a durable repair," said Tara Mastracci (Royal Free Hospital, London, UK) at the London Aortic Symposium 2018. Mastracci told Interventional News about how clinicians practices are being tested on the durability of aortic repair and how it is vital for operators to audit and evaluate their own data.. ...
I was diagnosed in 2012 with ascending aorta dialation of 4.1 cm. In 2013 no change. Finally went back to dr in 2017 and echo showed 4.3 cm. 2 months later dr made me have a chest scan which read 4.5 cm. which is correct? Echo or scan? Dr wants […]
Survival Technology - SonoSims new aorta and IVC real-patient scanning cases are available in the Aorta/IVC Core Clinical Module
Tortous Aorta is the problem related to the largest artery in our body- the aorta and is mostly found in small infants. It is curable and many patients lead a normal life after proper medication and treatment.
liekamoji dešinioji aorta statusas T sritis gyvūnų raida, augimas, ontogenezė, embriologija atitikmenys: lot. Aorta dextra persistens ryšiai: platesnis terminas - kraujagyslių ydos
Relaxation of Rat Aorta by Farrerol Correlates with Potency to Reduce Intracellular Calcium of VSMCs. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Researchers investigate the role of arterial stiffness in memory decline in older adults. A flexible aorta may be key to maintaining cognitive ability.
3) Liu X, Pu F, Fan YB, Deng XY, Li DY, Li SY(李淑宇). A numerical study on the flow of blood and the transport of LDL in the human aorta: the physiological significance of the helical flow in the aortic arch. Am J Physiol Heart Circ Physiol, 2009, 297(1):163-170 ...
НИИ атеросклероза: научные исследования, публикации сотрудников института (abstracts, full-text.), дискуссионный клуб, посвященный вопросам механизмов атерогенеза.
Occasionally, in an aorta diseased by arteriosclerosis, a tear de-velops in the intima or the media degenerates, resulting in a dis-section .
Hello, My daughter is seven and half years old. she had an open heart surgery in 2007 for closure of VSD. and till then echo is going on every year. Her Aorta size is 3.1 (Z score - 4.9) and it...
Read interesting answers and in fact write your own answer to the question Why blood entering the aorta from the reservoir flows into the heart?
The revision #92494 of the page named "Aorta VI" does not exist. This is usually caused by following an outdated history link to a page that has been deleted. Details can be found in the deletion log. ...
Aorta The Heart of Art is a Limited Liability Company Registered in England & Wales. Company Number 08878163. VAT Registration Number 206 050 753 ...
Aorta The Heart of Art is a Limited Liability Company Registered in England & Wales. Company Number 08878163. VAT Registration Number 206 050 753 ...
Az aorta stenosisban (AS) szenved szem lyek k z tt gyakori a magas v rnyom s s a v rnyom s optim lis cs kkent se sz ks ges az art ri s terhel s s a cardiovascularis esem nyek m rs kl s hez. Nem ismert, hogy a kalciumcsatorna-g tl k (CCB) biztons gosnak tekinthet k-e. K zepes vagy s lyos fok , ...
The aorta of mice involves certain challenges, such as resolution and partial volume effects. As all the animals have been treated similarly, the problems are
Treatment for an enlarged aorta depends on a variety of factors, including age and body size, medical history and the position and size of the enlargement.
Dont miss out on the latest Cta Abd Aorta Bi Iliofem Coupon right HERE. Pick one of our tested and updated vouchers - 100% verified and working ...
... - Vas de sange important care preia sangele pompat de inima si din care pleaca vase mari catre intreg organismul. Principala artera a organismului, formandu-se de la baza ventriculului stang si distribuind
What makes the Aorta Kukri blade great, is its ability to make deep penetrating cuts while piercing with ease as well as its ability to be moved quickly.
Saya (56 tahun) didiagnosis dokter mengidap penyakit aneurisma aorta bagian abdomen. Dari jantung kearah ginjal terjadi pembengkakan. Dokter menyarankan untuk
Program:Aorta betegs gei9.00- 9.20- Prenatalis diagnosztika. Dr. Lad nyi Anik Bicuspidalis aorta billenty 9.30-9.50 Bicuspidalis aorta billenty - plasztika feln tt korban- seb szeti lehet s gek, eredm nyek- Dr. Sz...
In England, screening for AAA is offered to men during the year they turn 65. This can help spot a swelling in the aorta early on, when it can be treated.. The test involves a quick and painless ultrasound scan to see how big your aorta is. If youre a man over 65 and you havent been screened, you can request a test by contacting your local AAA screening service directly. Women and men under 65 arent routinely invited for screening. But if you think you might have a higher risk of an AAA, talk to your GP about the possibility of having a scan.. Read more about screening for an AAA.. ...
Ez a webhely cookie-kat haszn l, melyekre sz ks g van a weboldal teljes m k d s hez. Weboldalunk b ng sz s vel n elfogadja a cookie-k haszn lat t ...
This article was originally based on an entry from a public domain edition of Grays Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant. ...
Sabesin, S. M. Proc. Soc. exp. Biol. Med., 112. 1963, 667. Saxen, E., L. Saxen, P. Grоnrооs. Aorta pathol. microbiol. scand., 44, 1958, 318. Saxen, L., E. ...
Hello. I need to culture bovine aortic smooth muscle cell. I do not know what medium should be used. What supplements or growth factors are required? In how much in amount? Please give me some help. Thanks in advance ...
Mouse Aortic Vascular Smooth Muscle Cells from Creative Bioarray are isolated from tissue of New Zealand White Rabbits. Rabbits Aortic Vascular Smooth Muscle Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Creative Bioarrays Cell Culture Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and is delivered frozen ...
Citation: Kumari, R. et al. (2003) ATP and UTP responses of cultured rat aortic smooth muscle cells revisited: Dominance of P2Y2 receptors. British Journal of Pharmacology, 140 (7), pp. 1169-1176. ...
TY - GEN. T1 - Multilayer properties of aorta. AU - Parenti, C.. AU - Laksari, K.. AU - Shafieian, M.. AU - Darvish, K.. PY - 2009/9/21. Y1 - 2009/9/21. N2 - Current finite element models of the aorta assume a homogenous material, but in fact aorta is composed of three major layers. Understanding of the material properties of these layers is essential in order to study the local mechanism of dynamic rupture. The material properties of aorta wall layers were determined from micro indentation tests. The results showed significant linear increase of the shear modulus in the inner half of media. A dominant viscoelastic behavior was observed which was almost uniform throughout the layers.. AB - Current finite element models of the aorta assume a homogenous material, but in fact aorta is composed of three major layers. Understanding of the material properties of these layers is essential in order to study the local mechanism of dynamic rupture. The material properties of aorta wall layers were ...
Volume 32: D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats
Aorta functions not only as a conduit delivering blood to the tissues but also as an important modulator of the entire cardiovascular system, buffering the intermittent pulsatile output from the heart to provide steady flow to capillary beds.1 By virtue of its elastic properties, aorta influences left ventricular function and coronary blood flow.2 3 4 5 Systemic hypertension, a common disorder with potentially serious complications, exerts further ill effects through structural and functional modifications of the arterial wall.6 7 Previous studies using different techniques have shown that aortic elastic properties are compromised in patients with arterial hypertension.8 9 10 11 12 13 14 Measurement of pulse wave velocity has been extensively used,9 10 11 providing only indirect estimations of the elastic properties of the aorta. Noninvasive methods11 12 13 14 using formulas involving pulsatile change in aortic dimensions and pulse pressure (the former is measured with echocardiography or ...
TY - JOUR. T1 - Impact of treatment modality on vascular function in coarctation of the aorta. T2 - The LOVE-COARCT study. AU - LOVE-COARCT Study. AU - Martins, José D.. AU - Zachariah, Justin. AU - Tierney, Elif Seda Selamet. AU - Truong, Uyen. AU - Morris, Shaine A.. AU - Kutty, Shelby. AU - de Ferranti, Sarah D.. AU - Guarino, Maria. AU - Thomas, Boban. AU - Oliveira, Diana. AU - Marinho, António. AU - António, Marta. AU - Gauvreau, Kimberlee. AU - Jalles, Nuno. AU - Geva, Tal. AU - Carmo, Miguel M.. AU - Prakash, Ashwin. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background-Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment) study was done to compare vascular function in patients with coarctation of the aorta treated with surgery, balloon dilation (BD), or stent ...
The aorta originates from the left ventricle of the heart. It ends in the abdomen where it branches into the two common iliac arteries. The aorta has five separate segments. The descending aorta begins at the arch of the aorta (where it loops over the heart to begin its descent).
The functions of resident CD11c+ myeloid cells in healthy mouse aorta and in the initiation of atherosclerosis. In atherosclerotic lesions, myeloid cells (macrophages and dendritic cells) and oxidatively-modified lipids accumulate underneath the endothelium in the arterial intima (the inner layer of the artery facing the lumen). Previously, we showed that in the normal mouse aorta CD11c+ myeloid cells reside preferentially in regions predisposed to atherosclerosis. Upon feeding a high cholesterol diet to atherosclerosis-susceptible low-density lipoprotein receptor deficient (LDLR-/-) mice, intimal CD11c+ cells accumulate intracellular lipid even prior to the recruitment of blood monocytes. Collectively, our studies showed that the low-grade monocyte recruitment in lesion-prone regions of the aorta accounts for resident intimal CD11c+ myeloid cell accumulation in the steady state, and that these cells promote atherosclerotic lesion formation and monocyte recruitment to the aortic intima in the ...
The air-filled ring was initially placed around the ascending aorta through a small tunnel in the periaortic fat. Extreme care was taken to avoid, as far as possible, damage of the penetrating vasa vasorum.1 When the hemodynamic condition of the animal was considered stable, the filling pressure of the ring was adjusted to be 60 mm Hg at diastole; this filling pressure was in every case below the aortic diastolic pressure of the animal, so that the ring would be in gentle contact with the aortic wall. At systole, the filling pressure of the ring increased by approximately 5 mm Hg because of the distension of the aorta (the exact value depended on the amount of distension of the aorta). Conditions of contact between the ring and the aortic wall were stable throughout the experiment. After placement of the ring, changes of the aortic diameter were recorded simultaneously with the ECG and the aortic pressures at a paper speed of 50 mm/s. To evaluate the data of each experimental subject, 10 ...
Human Aortic Endothelial Cell Genomic DNA ...
7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death / Mun Chual Rho; Young Kook Kim; Jong Sun Chang; Hyun Sun Lee; Jin Ah Baek; Mi Yeon Chung; H C Lee; H W Lee; B Y Rhim; M A Reidy; K Kim , 2005 ...
We thank Dr. Nelson and colleagues for their interest in our recent work concerning the effect of age on the biomechanical properties of the human aorta (1). We observed the greatest age-related difference in the aortic pulse wave velocity in the distal abdominal aorta, and the least in the aortic arch, suggesting that the distal aorta stiffened most with age. As we noted in our discussion, and as Dr. Nelson and colleagues reiterate, others have reported the converse, that is, that the ascending aorta stiffens most with age (2,3). No doubt, there are several explanations for these discrepant observations, not least the very small sample sizes reported by some authors (2,3), the use of differing techniques to estimate regional stiffness, methodological issues such as the use of nonsimultaneous, peripheral pressure when calculating distensibility/compliance (3), and technical issues such as inaccurate edge detection with cardiac magnetic resonance with varying sequences (4). Interestingly, a ...
Causes of Coarctation of aorta dominant including triggers, hidden medical causes of Coarctation of aorta dominant, risk factors, and what causes Coarctation of aorta dominant.
BioAssay record AID 577806 submitted by ChEMBL: Inhibition of 1-Nitrosocyclohexyl acetate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 0.1 to 1 mM.
How is comparison, aortic endothelial cells abbreviated? PAEC stands for comparison, aortic endothelial cells. PAEC is defined as comparison, aortic endothelial cells rarely.
During an abdominal aorta scan, the mobile technologist uses two types of ultrasound to systematically interrogate the entire length of the abdominal aorta. He
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the thickness of a garden hose and runs from your heart through your chest and abdomen, carryin
What is aortic disease? Aortic disease is a form of peripheral artery disease that affects the aorta, the largest artery in the body. The aorta is about the
When someone has coarctation of the aorta, that persons aorta (the major blood vessel that carries blood away from the heart to the body) is narrowed at some point.
Coarctation of the aorta (COA) is a narrowing of the aorta, the major blood vessel that carries blood away from the heart to the body.
When someone has coarctation of the aorta, that persons aorta (the major blood vessel that carries blood away from the heart to the body) is narrowed at some point.
Coarctation of the aorta is a heart defect that is present at birth (congenital). It means the aorta is narrower than it should be. Read on to learn details about the condition.
Coarctation of the aorta is a narrowing of the aorta. It can lead to worsening heart function over time, but effective treatments are available.
Arterial glycosaminoglycans are considered to be important in atherogenesis due to their ability to trap lipid inside the vessel wall and to influence cellular migration and proliferation. Atherosclerotic lesions have displayed an altered glycosaminoglycan content and distribution. Diabetes is a rec …
Anevrismul aortic reprezinta o zona slabita si „umflata" in peretele aortei. Aorta este vasul de sange de dimensiuni mari, care transporta sangele bogat in oxigen de la inima la restul organismului. Aorta anevrismala este slabita si se poate rupe, determinand o hemoragie ce poate pune in pericol viata. Ruperea anevrismului aortic este pe locul 15 in lista cauzelor de deces si apare la una din 12 persoane in varsta. Exista 2 tipuri de anevrism aortic: anevrismul aortic abdominal si anevrismul aortic toracic. Aceasta clasificare se bazeaza pe localizarea anevrismului de-a lungul traiectului aortei. Regiunea toracica a aortei traverseaza partea de sus (toracica) a corpului si furnizeaza sange bogat in oxigen in aceasta regiune. Regiunea abdominala a aortei este in continuarea celei toracice, de-a lungul abdomenului si asigura aportul de sange bogat in oxigen in partea de jos a corpului. Anevrismele pot aparea in orice zona a aortei, dar cel mai frecvent apar in partea abdominala.. #gallery-1 { ...
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Double aortic arch is a common form of a group of defects that affect the development of the aorta in the womb. These defects cause an abnormal formation called a vascular ring (a circle of blood vessels).. Normally, the aorta develops from one of several curved pieces of tissue (arches). As babies develop in the womb, the arches split into several parts. The body breaks down some of the arches, while others form into arteries. A normally developed aorta is a single arch that leaves the heart and moves leftward.. In double aortic arch, some of the arches that should have disappeared are still present at birth in addition to the normal arch. Babies with a double aortic arch have an aorta that is made up of two vessels instead of one. The two parts to the aorta have smaller arteries branching off of them. As a result, the two branches go around and press down on the windpipe and the tube (esophagus) that carries food from the mouth to the stomach. A double aortic arch may occur in other congenital ...
НИИ атеросклероза: научные исследования, публикации сотрудников института (abstracts, full-text.), дискуссионный клуб, посвященный вопросам механизмов атерогенеза.
An impedance pump - also known as Liebau pump - is a simple valveless pump that operates based on the principles of wave propagation and reflection. It has been shown in embryonic zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during the early stages before valve formation.... Go to the Article ...
FIGURE 1. (A) Schematic setup of the stereo-vision system to focus on a specimen, (B) specimen images taken by each camera, and (C) the reconstructed positions of markers affixed to the specimen in the 3D coordinate system. [Color figure can be viewed in the online issue, which is available at] - Longitudinal differences in the mechanical properties of the thoracic aorta depend on circumferential regions.
The aim of this study was to explore the clinical impact of transverse aortic arch hypoplasia (TAH) after stent implementation for isthmal coarctation of the aorta (CoA). From a retrospective chart...
The gradient across coarctation is not simply (& solely ) determined by degree of obstruction , as one would believe.Understanding the hemodynamics and various factors that can influence the gradient is essential Relieving the obstruction /gradient by stent or surgery may not be synonymous with successful treatment as we understand now the entire aorta right…
Learn more about the possible symptoms of coarctation of the aorta, including hypertension, chest pain, claudication, and headaches.
We need to stay vigilant for the needles in the haystack of pediatric illnesses. One of those needles is Coarctation of the Aorta.
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Helpful, trusted answers from doctors: Dr. Hahn on aorta fem bypass: A coronary artery bypass brings more blood to the heart muscle by connecting a new tube(vein or artery) past a blockage in an artery on the heart.
A blood vessel of arterial type, which is the largest artery in the human body. It originates from the left ventricle of the heart and ends in the pelvis, where it divides into two femoral arteries, each of which supplies one of the lower extremities, the right and the left, respectively. Along its entire course, smaller arteries originate from the aorta, which supply oxygenated blood to all body organs.. ...
The aorta is the largest blood vessel in the body and is made of four crucial parts that carry oxygen-rich blood from the heart to the rest of the body.
Gu a pr ctica y actualizada de la patolog a aneurism tica de la aorta abdominal, con una completa rese a de los conocimientos acerca de su patogenia, formas de presentaci n, diagn stico, criterios de decisi n y tratamiento, con iconograf a original, sin omitir aspectos generales e hist ricos. En un estilo directo y sencillo, resultar accesible aun para los m dicos ajenos a la especialidad de Cirug a Vascular.
When Frank Englerths aorta began to rupture, the stabbing pain high in his back woke him in the middle of a cold February night. It was the beginning of what could have been the end for Englerth, 74, who lives on the Saline River deep in southeastern Arkansas, nearly a…
YellowKorner recommends a Photograph by AORTA entitled Father and Daughter. Discover our Photograph in various dimensions with a selection of finishes, on the YellowKorner website
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I was reminded yesterday to Breathe. Sometimes I forget that. This can get so stressful and overwhelming sometimes, but always important to remember. Even more than just remembering to Breathe, Im going to start incorporating more meditation into my day. When I am in a ton of pain, and stressed out, it is very easy…
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BioAssay record AID 421037 submitted by ChEMBL: Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of ratio of Rac1GTP/Rac1 levels at 25 uM after 4 hrs by pull-down assay.
Aortic calcification was demonstrated in experimental animal models of hyperhomocysteinemia. Mild hyperhomocysteinemia was associated with aortic calcification, suggesting a relationship between homocysteine (HCY) and the pathogenesis of aortic calcification. In the present study, the effect of HCY on vascular calcification was examined in calcifying and non-calcifying vascular smooth muscle cells (VSMCs). Cell calcification was induced by incubation of VSMCs with [ glycerophosphate. Proliferation of VSMCs was studied by cell counting, H-3-thymidine (H-3-TdR) and H-3-leucine (H-3-Leu) incorporation. Ca-45 accumulation, cell calcium content, and alkaline phosphatase (ALP) activity were measured as indices of calcification. The results showed that the proliferation of calcifying VSMCs, which was indicated by cell counting, H-3-TdR and H-3-Leu incorporation in calcifying VSMCs, was enhanced as compared with that of non-calcifying VSMCs. HCY promoted increases in cell number, H-3-TdR and H-3-Leu ...
The cytotoxicity of oxidized low-density lipoprotein (Ox-LDL) to arterial smooth muscle cells (SMCs) may contribute to atherogenesis by causing cell death in core regions of plaques. The aim of the present study was to identify the components of copper-oxidized LDL responsible for its toxicity to porcine aortic SMCs. Toxicity to SMCs was assessed as the decrease in viable cell counts after 3-day cell incubation. Extracts of LDL were tested for toxicity at concentrations equivalent to that derived from 100 micrograms LDL protein per milliliter. Lipid extracts of Ox-LDL but not native-LDL were toxic to SMCs. When separated into neutral and polar lipid classes, only the neutral lipids were toxic (89.7 +/- 0.7% cell loss). The neutral lipids were fractionated further by use of solid-phase extraction and high-performance liquid chromatography (HPLC). Two toxic fractions, causing 93.3% and 60.3% cell loss, were isolated from HPLC and analyzed by gas chromatography/mass spectrometry. The most toxic of ...
TY - JOUR. T1 - Gender and transcriptional regulation of NO synthase and ET-1 in porcine aortic endothelial cells. AU - Wang, Xiaofang. AU - Barber, Dustan A.. AU - Lewis, Debraa. AU - McGregor, Christopher G A. AU - Sieck, Gary C. AU - Fitzpatrick, Lorraine A.. AU - Miller, Virginia M. PY - 1997. Y1 - 1997. N2 - Experiments were designed to deter-mine whether normal fluctuations in sex steroid hormones alter gene transcription for endothelial nitric oxide synthase (NOS) and preproendothelin-1 (prepro-ET-1). Aortic endothelial cells were removed from adult, gonadally intact male and female or ovariectomized Yorkshire pigs. Endothelial cells were prepared for Northern blot analysis, Western blot analysis or enzyme activity. Nitric oxide products (NOx) and endothelin-1 (ET-1) in plasma were measured by chemiluminescence and radioimmunoassay, respectively. Northern blot analysis identified single bands corresponding to endothelial NOS and prepro-ET-1. Quantification of the blots showed an increase ...
The descending thoracic aorta arises from the aortic arch just after the origin of the left subclavian artery, at the inferior border of the fourth thoracic vertebrae. This point of transition is termed the aortic isthmus. In adults, the average diameter of the descending thoracic aorta is 2.8 cm in men and 2.6 cm in women.2 This narrows as it descends into the abdomen. It terminates as it enters the abdomen via the diaphragmatic aortic hiatus, at the 12th intercostal space. The thoracic aorta descends in the posterior mediastinum to the left of the vertebral column and gradually shifts to the midline at the aortic hiatus. It is surrounded by the thoracic aortic plexus. Anteriorly, the left pulmonary hilum crosses with the left main bronchus and left pulmonary artery being closely associated. Continuing inferiorly, the esophagus, pericardium, and diaphragm are also situated at the anterior border of the thoracic aorta. As the thoracic aorta descends, the esophagus crosses anteriorly and then ...
Bovine aortic smooth muscle cells (BASMC) in culture have been shown to oxidatively modify human low-density lipoprotein (LDL). Such oxidized LDL appears to be a significant factor in the etiology of atherosclerosis. This ...
Looking for online definition of Aorta dissection in the Medical Dictionary? Aorta dissection explanation free. What is Aorta dissection? Meaning of Aorta dissection medical term. What does Aorta dissection mean?
Looking for online definition of Coarction of the Aorta in the Medical Dictionary? Coarction of the Aorta explanation free. What is Coarction of the Aorta? Meaning of Coarction of the Aorta medical term. What does Coarction of the Aorta mean?
Background: Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic periodontitis. In addition, this bacterium is also involved in the development of cardiovascular disease. The aim of this study was to investigate the effects of P. gingivalis infection on gene and protein expression in human aortic smooth muscle cells (AoSMCs) and its relation to cellular function.. Results: AoSMCs were exposed to viable P. gingivalis for 24 h, whereafter confocal fluorescence microscopy was used to study P. gingivalis invasion of AoSMCs. AoSMCs proliferation was evaluated by neutral red assay. Human genome microarray, western blot and ELISA were used to investigate how P. gingivalis changes the gene and protein expression of AoSMCs. We found that viable P. gingivalis invades AoSMCs, disrupts stress fiber structures and significantly increases cell proliferation. Microarray results showed that, a total of 982 genes were identified as differentially expressed with the threshold log2 ...
Abstract. Caldesmon, an inhibitory actin binding protein, binds to actin and inhibits actin-myosin interactions, whereas caldesmon phosphorylation reverses the inhibitory effect of caldesmon on actin-myosin interactions, potentially leading to enhanced contraction. The goal of this study was to investigate the cellular signaling pathway responsible for caldesmon phosphorylation, which is involved in the regulation of the contraction induced by dexmedetomidine (DMT), an alpha-2 adrenoceptor agonist, in endothelium-denuded rat aortas. SP600125 (a c-Jun NH2-terminal kinase [JNK] inhibitor) dose-response curves were generated in aortas that were pre-contracted with DMT or phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator. Dose-response curves to the PKC inhibitor chelerythrine were generated in rat aortas pre-contracted with DMT. The effects of SP600125 and rauwolscine (an alpha-2 adrenoceptor inhibitor) on DMT-induced caldesmon phosphorylation in rat aortic vascular smooth muscle ...
The normal range for aortic root diameters employing the echocardiographic continuous recording technique was determined in 159 adult subjects without aortic valve disease or hypertension. In order to evaluate the accuracy of this noninvasive technique, the aortic root diameters as measured by ultrasound before operation in 31 patients with aortic valve disease were compared with their respective aortic annulus diameters as determined at the time of valve replacement. The 159 normal subjects consisted of 78 men and 81 women whose ages ranged from 18 to 74 pears (average 38). The normal range of aortic root diameters in this group was 17 to 33 mm (mean 23.7). A significant difference (P is smaller than 0.001) in aortic root diameters existed between men and women which could not be explained by differences in body surface area. The mean diameter among the 81 women was 22.4 plus or minus 3.3 mm(I SD) compared to the mean diameter in the 78 men of 25 plus or minus 3.5 mm. These results indicate a ...
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, including Qatar. Hypertension is one of the most common CVDs that contribute to this mortality. Cadmium is a well-known pollutant that has been suggested to be a risk factor for hypertension. However, the underlying mechanisms are still lacking. Very little is known about the effect of cadmium on the expression of vascular alpha- 1 adrenoceptors in vascular smooth muscle cells (VSMCs). This study was therefore undertaken to determine the effect of cadmium on the expression of vascular alpha-1 adrenergic receptors in vitro. Along with that, there are several phenotypic changes could modulate the VSMCs function and contribute to CVDs including hypertension. These changes include hypertrophy, migration and senescence. The second objective of this study was to determine the effect of cadmium on VSMCs phenotype. Human aortic smooth muscle cells (HASMCs) were incubated with different concentrations of cadmium chloride for varying
TY - JOUR. T1 - Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats. AU - Kawada, Toru. AU - Turner, Michael J.. AU - Shimizu, Shuji. AU - Fukumitsu, Masafumi. AU - Kamiya, Atsunori. AU - Sugimachi, Masaru. PY - 2017/5/30. Y1 - 2017/5/30. N2 - Recent clinical trials in patients with drug-resistant hypertension indicate that electrical activation of the carotid sinus baroreflex (baroreflex activation therapy) can reduce arterial pressure (AP) for more than a year. To examine whether the electrical stimulation from one baroreflex system impedes normal short-term AP regulation via another unstimulated baroreflex system, we electrically stimulated the left aortic depressor nerve (ADN) while estimating the dynamic characteristics of the carotid sinus baroreflex in anesthetized normotensive Wistar-Kyoto (WKY, n=8) rats and spontaneously hypertensive rats (SHR, n=7). Isolated carotid sinus ...
TY - JOUR. T1 - Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells. AU - Chang, Tuanjie. AU - Untereiner, Ashley. AU - Liu, Jianghai. AU - Wu, Lingyun. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Hydrogen sulfide (H2S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the effect of MG on H2S synthesis and the interaction between these two endogenous substances. In cultured vascular smooth muscle cells (VSMCs), MG (10, 30, and 50μM) significantly decreased cellular H2S levels in a concentration-dependent manner, while H 2S donor, NaHS (30, 60, and 90μM), significantly decreased cellular MG levels. The expression level and activity of H2S- producing enzyme, cystathionine γ-lyase (CSE), were significantly decreased by MG treatment. ...
TY - JOUR. T1 - Endovascular management of pseudoaneurysm formation in the ascending aorta following lung transplantation. AU - Joyce, David L.. AU - Singh, Steve K.. AU - Mallidi, Hari R.. AU - Dake, Michael D.. PY - 2012. Y1 - 2012. N2 - Purpose: To demonstrate the role of endovascular approaches to the ascending aorta in the post-transplant context. Case Reports: Three patients (2 women and 1 man aged 52, 68, and 43 years, respectively) developed pseudoaneurysm of the ascending aorta following thoracic organ transplantation. Due to the prohibitive risk of open surgery in each case, an endovascular repair of the ascending aorta was performed, with implantation of 1 to 3 stent-grafts to span the lesions. Follow-up imaging demonstrated complete exclusion of the pseudoaneurysms, with excellent outcomes at 4 months, 6 months, and 3 years. Conclusion: Stent-grafting of the ascending aorta represents a viable approach to pseudoaneurysm in the post-transplant setting.. AB - Purpose: To demonstrate ...

Takayasu arteritisTakayasu arteritis

... and proximal dilatation of the aorta can cause aortic regurgitation, dilated cardiomyopathy, and congestive heart failure. ...
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Coarctation of the aorta - WikipediaCoarctation of the aorta - Wikipedia

Coarctation of the aorta (CoA or CoAo), also called aortic narrowing, is a congenital condition whereby the aorta is narrow, ... The severity of coarctation of the aorta can be rated by a combination of the smallest aortic cross-sectional area of the aorta ... Since the aorta is narrowed, the left ventricle must generate a much higher pressure than normal in order to force enough blood ... The characteristic bulging of the sign is caused by dilatation of the aorta due to an indrawing of the aortic wall at the site ...
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Coarctation of the AortaCoarctation of the Aorta

... that persons aorta (the major blood vessel that carries blood away from the heart to the body) is narrowed at some point. ... Coarctation of the Aorta. Resources. Please Note: By clicking a link to any resource listed on this page, you will be leaving ... When someone has coarctation of the aorta, ...
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Coarctation of the AortaCoarctation of the Aorta

... that persons aorta (the major blood vessel that carries blood away from the heart to the body) is narrowed at some point. ... What Is Coarctation of the Aorta?. The aorta (pronounced: ay-OR-tuh) is the major artery that carries blood away from the heart ... Coarctation of the aorta can be repaired in several ways. Surgery can very effectively repair a narrowing of the aorta, usually ... When someone has coarctation (pronounced: ko-ark-TAY-shun) of the aorta, that persons aorta is narrowed at some point. ...
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Aorta - WikipediaAorta - Wikipedia

Aorta er hovedpulsåren hos dyr, særlig pattedyr. Aorta fører blod fra venstre hjertekammer ut i kroppen. Aorta hos andre dyr er ... aorta · brachiocephalica/innominata · bronchialis · thoracic (thoracis lateralis, thoracica interna) · subclavia · vertebralis ... Hos dyr med åpent blodsystem er ofte aorta den eneste tydelige delen av bodåresystemet. ... Hentet fra «» ...
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Berekend opleiden (AORTA-model) | SpringerLinkBerekend opleiden (AORTA-model) | SpringerLink

Om dit probleem van overschotten en tekorten te voorkomen, is er het zogenoemde AORTA-model. Dit model is in dit hoofdstuk ... Berrevoets L., Berden B., van den Brink G. (2016) Berekend opleiden (AORTA-model). In: Berden B., Berrevoets L., Winasti W. ( ...
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Thoracic Aorta | SpringerLinkThoracic Aorta | SpringerLink

The close proximity of the esophagus to the thoracic aorta provides an excellent imaging opportunity. Transesophageal ... Thoracic aorta Aortic dissection Aortic aneurysm Atheromatous disease Plaque Blunt aortic trauma ... Maus T.M. (2016) Thoracic Aorta. In: Maus T., Nhieu S., Herway S. (eds) Essential Echocardiography. Springer, Cham. * First ... Midesophageal view of ascending aorta developed by a slow withdrawal of the probe from an aortic valve short axis (M4V 641 KB) ...
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enlarged aorta - Postsenlarged aorta - Posts

Treatments and Tools for enlarged aorta. Find enlarged aorta information, treatments for enlarged aorta and enlarged aorta ... MedHelps enlarged aorta Center for Information, Symptoms, Resources, ... Posts on enlarged aorta. enlarged aorta 3.8cm - Heart Disease Expert Forum ... I have controlled high blood pressure,and enlarged aorta. Will my aorta ever go back to its... ...
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Aorta - Cardiovascular SystemAorta - Cardiovascular System

The descending aorta is broken down into two sections - the thoracic aorta and abdominal aorta - named after the body cavities ... Continued From Above... section of the aorta is known as the ascending aorta. The ascending aorta branches into the left and ... Aorta. At about one inch in diameter and traveling almost the entire length of the trunk, the aorta is the largest artery in ... Thus, the aorta provides oxygenated blood flow to all of the tissues of the body. The wall of the aorta is very thick and ...
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Takayasu Disease: Symptoms of Aorta InflammationTakayasu Disease: Symptoms of Aorta Inflammation

... a chronic inflammation of the aorta. Takayasu disease symptoms include dizziness, headaches, chest pain, and abdominal pain. ... The inflammation of the aorta and its branch arteries can lead to poor blood supply to tissues of the body in patients with ... Some researchers have found that the prognosis is worse when the retinas of the eyes are affected, if the aorta is damaged, or ... Abdominal aortic aneurysm is a ballooning or widening of the main artery (the aorta) as it courses down through the abdomen. ...
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A supple aorta might slow brain agingA supple aorta might slow brain aging

A flexible aorta may be key to maintaining cognitive ability. ... A supple aorta might slow brain aging. Written by Tim Newman on ... The aorta is the main artery in the body, carrying blood from the heart and down through the abdomen before splitting off into ... The role of the aorta. In particular, the team is interested in the potential relationship between cognitive decline and the ... A healthier, more elastic aorta is also theorized to protect cognitive function by reducing the negative effects of excessive ...
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Coarctation of the aorta | physiology | Britannica.comCoarctation of the aorta | physiology |

... of a short section of that portion of the aorta that arches over the heart. The aorta is the principal artery conducting blood ... Coarctation of the aorta, congenital malformation involving the constriction, or narrowing, ... cardiovascular disease: Coarctation of the aorta. Coarctation of the aorta, which is a constriction of the aorta, usually in ... aorta. Aorta. , in vertebrates and some invertebrates, the blood vessel (or vessels) carrying blood from the heart to all the ...
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Aorta abdominalis definition | Drugs.comAorta abdominalis definition |

Definition of aorta abdominalis. Provided by Stedmans medical dictionary and Includes medical terms and definitions ... Synonym(s): abdominal aorta. Further information. Always consult your healthcare provider to ensure the information displayed ...
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Enlarged Aorta - Heart Disease - MedHelpEnlarged Aorta - Heart Disease - MedHelp

He has been diagnosed with an enlarged Aorta and been told that something will need to be done within the next five years. He ... Enlarged Aorta gaving I live in the UK and my best friend and I have turned 50 this year. He has been diagnosed with an ... Enlarged Aorta. I live in the UK and my best friend and I have turned 50 this year. He has been diagnosed with an enlarged ... We are both big Pittsburgh Steelers and Penguins fans and I see that there is big developments in Aorta procedures in the ...
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HIV and the aorta | TheBodyHIV and the aorta | TheBody

Hi Dr. Henry My father and brother have both had an aortic dissection. It was fatal to my father but luckily little brother caught it in time and is recovering. My local cardiologist said that since I
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Stories: Coarctation of the Aorta | Birth Defects | NCBDDD | CDCStories: Coarctation of the Aorta | Birth Defects | NCBDDD | CDC

Coarctation of the aorta is a birth defect in which a part of the aorta is narrower than usual. To learn what its like to live ... Coarctation of the aorta is a narrowing of part of the aorta (the major artery that supplies oxygenated blood to the entire ... Nicholas was born with a serious heart defect called critical coarctation of the aorta, a severe narrowing in his aorta cutting ... Nicholas was born with a critical congenital heart defect (critical CHD) called coarctation of the aorta. Read his ...
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Coarctation of the aorta: MedlinePlus Medical Encyclopedia ImageCoarctation of the aorta: MedlinePlus Medical Encyclopedia Image

Coarctation of the aorta is a birth defect in which the aorta, the major artery from the heart, is narrowed. The narrowing ... Coarctation of the aorta is a birth defect in which the aorta, the major artery from the heart, is narrowed. The narrowing ...
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Google Answers: Aneurism of the aortaGoogle Answers: Aneurism of the aorta

Subject: Aneurism of the aorta Category: Health Asked by: bob2-ga List Price: $5.00. Posted: 16 Aug 2002 03:12 PDT Expires: 15 ... Subject: Re: Aneurism of the aorta Answered By: alienintelligence-ga on 16 Aug 2002 05:33 PDT ... Can an aneurism of a rupture of the aorta be caused by alcoholism?. ... The stress of hypertension or high blood pressure to the wall of the aorta over many years can lead to enlargement of the blood ...
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Congenital Heart Defects - Facts about Coarctation of the Aorta | CDCCongenital Heart Defects - Facts about Coarctation of the Aorta | CDC

Learn about the heart birth defect Coarctation of the Aorta. ... What is Coarctation of the Aorta?. Coarctation of the aorta is ... If the aorta is not widened, the heart may weaken enough that it leads to heart failure. Coarctation of the aorta often occurs ... Coarctation (pronounced koh-ark-TEY-shun) of the aorta is a birth defect in which a part of the aorta, the tube that carries ... The stent is used more often to initially widen the aorta or re-widen it if the aorta narrows again after surgery has been ...
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Aorta - WikipediaAorta - Wikipedia

... the aorta then travels inferiorly as the descending aorta. The descending aorta has two parts. The aorta begins to descend in ... Ascending aortaEdit. Main article: Ascending aorta. The ascending aorta begins at the opening of the aortic valve in the left ... Abdominal aortaEdit. Main article: Abdominal aorta. The abdominal aorta begins at the aortic hiatus of the diaphragm at the ... Thoracic aortaEdit. Main article: Descending thoracic aorta. The thoracic descending aorta gives rise to the intercostal and ...
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Aorta | CTSNetAorta | CTSNet

... of an ascending aorta and arch replacement with elephant trunk technique and endovascular treatment of the descending aorta. ... aortic root/hemiarch reconstruction with the use of a handmade bovine pericardial aortic tube to replace the ascending aorta ...
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Aorta | HeartAorta | Heart

Diseases of the aorta and trauma to the aorta and heart (2) ... A Patient-Specific Assessment of The Thoracic Aorta Pouya ...
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The Aorta (Human Anatomy): Picture, Function, Location, and ConditionsThe Aorta (Human Anatomy): Picture, Function, Location, and Conditions

Learn about its function and location as well as conditions that affect the aorta. ... WebMDs Aorta Anatomy Page provides a detailed image and definition of the aorta. ... The aorta is the largest artery in the body. The aorta begins at the top of the left ventricle, the hearts muscular pumping ... The aorta is a tube about a foot long and just over an inch in diameter. The aorta is divided into four sections:. • The ...
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You Say Aorta, I Say I OughttaYou Say Aorta, I Say I Oughtta

And then there are problems like switching aorta for atrial, which may not be typos and shouldnt happen if one is paying ...
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Descending part of aorta definition | Drugs.comDescending part of aorta definition |

Definition of descending part of aorta. Provided by Stedmans medical dictionary and Includes medical terms and ... Synonym(s): descending aorta. Further information. Always consult your healthcare provider to ensure the information displayed ...
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  • To learn what it's like to live with this condition or how families are affected, read these real stories from people living with coarctation of the aorta. (
  • ] The alcohol related pathogenesis or development of the diseased condition of cardiac damage is charaterized by occurance of both systolic and diastolic hypertension, arrhythmias and alcoholic cardiomyopathy or a condition where the heart muscle is weakened and cannot pump blood efficiently. (
  • This is the leading predisposing factor for the development of aneurysm of the thoracic aorta' FAQ on alcoholism [ ] Now, as far as your question: Can an aneurism of a rupture of the aorta be caused by alcoholism? (
  • Abdominal aorta aneurysm is rare too and mostly develops secondary to Behcet's disease, trauma, and infection or connective tissue diseases. (
  • Abdominal ultrasound and contrast-enhanced computerized tomography revealed an infrarenal abdominal aorta aneurysm in a 41-year-old woman, but, on surgery, retroperitoneal fibrosis surrounding the aorta was detected. (
  • We present this interesting case because retroperitoneal fibrosis encircling the abdominal aorta can mimic abdominal aorta aneurysm radiologically. (
  • The clinical enquiry for thoracoabdominal CTA included: a) follow-up after thoracic vascular surgery or endovascular repair, b) follow-up of untreated ascending aorta aneurysm or untreated dissection, c) suspected acute aortic syndrome. (
  • It was disappointing to learn about this magnitude of steroid use in this patient population as [ruptured abdominal aorta aneurysm] is considered as a traumatic condition and to have only limited inflammatory impact on disease development," said Faron Chief Executive Markku Jalkanen. (
  • Dr Mohammad Saeed Qureshi said that abdominal aorta is the enlargement of the aneurysm just like a balloon, which if ruptured, can be life-threatening. (
  • Palpating the stomach to examine the abdominal aorta is frequently performed by doctors to screen for peripheral artery disease and to assess a person's risk of suffering an aneurysm, states (
  • 1 Grafts may be introduced during open or endovascular procedures to prevent rupture of an expanding vascular aneurysm, usually in the abdominal aorta. (
  • There was no specific evidence of aortic aneurysm or dissection, therefore a spontaneous rupture of the ascending aorta was diagnosed. (
  • A method and device for occluding a patient's ascending aorta, maintaining circulation of oxygenated blood in the patient and delivering cardioplegic fluid to arrest the patient's heart. (
  • The present invention is directed to methods and devices for occluding a patient's ascending aorta and maintaining circulation of oxygenated blood in the patient when the patient's heart is arrested. (
  • Another device and method for occluding a patient's ascending aorta is described in Re. (
  • The descending aorta begins at the arch of the aorta (where it loops over the heart to begin its descent). (
  • Stanford type A dissections involve the ascending aorta and type B dissections occur distal to the subclavian artery (4). (
  • Thoracic aortic aneurysms (TAAs) involve the ascending aorta most commonly (50%), followed by the descending aorta (40%), whereas arch aneurysms (10%) and thoraco-abdominal aneurysms (10%) occur less often. (
  • In the past, coarctation of the aorta has been described as preductal (or infantile) type or postductal (or adult) type, depending on whether the coarctation segment is proximal or distal to the ductus arteriosus, respectively. (
  • The classic coarctation of the aorta is located in the thoracic aorta distal to the origin of the left subclavian artery at about the level of the ductal structure. (
  • Dilatation of the descending aorta immediately distal to the coarctation segment (poststenotic dilatation) is usually present. (
  • Coarctation of the aorta is a narrowing of the descending aorta, which is typically located at the insertion of the ductus arteriosus just distal to the left subclavian artery ( figure 1 ). (
  • Type B: Intimal tear not involving the ascending aorta (in the descending aorta distal to the left subclavian artery and limited to the descending aorta). (
  • Small aneurysms can be patched, but large aneurysms can lead to a potentially deadly tearing of the aorta known as an aortic dissection. (
  • These diseases affect the media of the aorta and predispose it to dissection. (
  • In this video, the authors demonstrate a two-stage hybrid treatment for DeBakey type I aortic dissection, consisting of an ascending aorta and arch replacement with elephant trunk technique and endovascular treatment of the descending aorta. (
  • A CT angiogram of the abdominal aorta was done, revealing significant thickening of the wall of the abdominal aorta with luminal narrowing, and there was a focal dissection flap in the aorta near the renal artery ostia site (Figure 1). (
  • An aortic dissection is a split between the layers of the aorta that traps blood coming from the heart. (
  • It also can cause dissection or rupture of the aorta, which can be fatal. (
  • Aortic dissection is the most common life-threatening disorder affecting the aorta. (
  • Aortic Dissection can quickly lead to a painful and frightening death as a result of reduced blood flow to the heart or rupture of the aorta. (
  • Think Aorta" Timely detection and treatment of Aortic Dissection will save lives. (
  • Some patients with coarctation of the aorta may have cerebral aneurysms, predisposing them to cerebrovascular accidents with severe hypertension later in life. (
  • The results of this study showed that the majority of mycotic aneurysms caused by Salmonella were in the abdominal aorta (37/57), and some patients present diarrhea when infected with Salmonella. (
  • Aneurysms and dissections of the aorta are life-threatening conditions and should be treated as a medical emergency. (
  • Surgical repair of aorta may be required for aortic aneurysms, aortic dissections or congenital malformations such as coarctation. (
  • People at increased risk include those with a history of blockages or aneurysms (abnormal bulges) of the aorta or other blood vessels, high blood pressure, certain genetic disorders that involve blood vessel changes, and the elderly. (
  • Takayasu disease is a chronic inflammation of the large blood vessels that distribute blood from the heart, including the aorta and its main branches. (
  • Intercostal (between-the-ribs) branches from the aorta enlarge and cause characteristic notching of the ribs. (
  • Most of the major organs receive blood from branches of the abdominal aorta. (
  • Coarctation of the aorta: Narrowing of the aorta between its branches to the arms and those to the legs. (
  • The right branches are longer than the left, because the descending aorta (thoracic aorta) is on the left side of the vertebrae. (
  • The abdominal aorta and its branches. (
  • It runs parallel to the inferior vena cava , which is located just to the right of the abdominal aorta, and becomes smaller in diameter as it gives off branches. (
  • 17) reported a patient who had trombus in the abdominal aorta and its branches and who underwent Fogart thrombectomy, but who was lost because of sepsis. (
  • Inflammation of the aorta. (
  • The causes of aortic atherosclerotic disease include high blood pressure, diabetes, smoking, high cholesterol contents in the aorta and inflammation diseas. (
  • At 16 weeks, there were no significant differences in vascular inflammation between the treatment and control arms, based on the change from baseline in the vessel wall target to background ratio from the ascending aorta (the primary endpoint). (
  • In this system, the aorta starts as the ascending aorta then travels superiorly from the heart and then makes a hairpin turn known as the aortic arch . (
  • : 191,204 The transition from ascending aorta to aortic arch is at the pericardial reflection on the aorta. (
  • The authors demonstrate how to use one homograft root in reoperative infected aortic root/hemiarch reconstruction with the use of a handmade bovine pericardial aortic tube to replace the ascending aorta and unite the divided homograft. (
  • The ascending aorta rises up from the heart and is about 2 inches long. (
  • for this reason, the patient underwent elective ascending aorta replacement and conservative aortic valve surgery at age 5. (
  • It was observed that two brachiocephalic trunks branched off from the ascending aorta in the greater flamingos. (
  • How would you define ascending aorta? (
  • values between 1.1 and 1.5 are considered dilated or ectatic ascending aorta. (
  • The aorta has three segments: Ascending aorta, transverse aortic arch, and descending aorta. (
  • Type A: Intimal tear in the ascending aorta that involves the ascending aorta only. (
  • An aortic occlusion catheter has an occluding member for occluding the ascending aorta. (
  • The methods and devices described in the above-mentioned patents use an internal occlusion device to occlude the ascending aorta rather than a conventional external cross-clamp. (
  • A contrast chest CT scan revealed a hematoma around the ascending aorta and a notch in the aortic wall, suggesting an intimal tear. (
  • At about one inch in diameter and traveling almost the entire length of the trunk, the aorta is the largest artery in the human body. (
  • According to a study in older adults, memory performance as we age may be associated with the flexibility of the largest artery in our body: the aorta. (
  • The aorta is the largest artery in the body. (
  • A tortuous aorta happens when the largest artery in the body twists in an unnatural and potentially dangerous way, according to InnovateUs. (
  • The abdominal aorta is the largest artery in the abdominal cavity . (
  • Samples of lung and dorsal aorta were fixed in Bouin's solution for 24 h and embedded in paraffin. (
  • The level of MDA and GSH in blood, lung and dorsal aorta showed normal values (Tables I, II and III). (
  • It is observed also that exposure to IR and/or PQ significantly increased malondialdehyde (MDA) while decreased glutathione content (GSH) in the blood, lung and dorsal aorta indicating oxidative stress and increased lipid peroxidation. (
  • The patterns of most plasma free amino acid concentrations from force-fed rainbow trout with and without dorsal aorta cannulation were similar, and the dorsal aorta cannulation did not affect their patterns (Bae et al. (
  • This suggests the dorsal aorta technique can be used to estimate the requirement of other amino acids by rainbow trout. (
  • Results of post-prandial plasma free methionine concentrations (PPmet, 5 h after intubation) and post-absorptive plasma free methionine concentrations (PAmet, 24 h after intubation) in dorsal aorta cannulated rainbow trout force-fed with diets containing seven graded levels of methionine are shown in Figure 1. (
  • The patterns of plasma free amino acids after force-feeding in rainbow trout, Oncorhynchus mykiss with and without dorsal aorta cannulation. (
  • Evaluation of feed protein quality by measuring plasma free amino acids in Atlantic salmon, Salmo salar after dorsal aorta cannulation. (
  • The dorsal aorta artery was then intubated with a 2-mm diameter, 50-mm long polyethylene cannula through which physiological solution was introduced to wash the system. (
  • Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta. (
  • The present study investigated the role of arachidonic acid and acetylcholine in mediating endothelium-dependent relaxations of rabbit aorta. (
  • Arachidonic acid and acetylcholine had no effect on denuded rabbit aorta. (
  • Incubation of rabbit aorta with [14C]arachidonic acid resulted in the synthesis of major radioactive metabolites that comigrated with the prostaglandins and hydroxyeicosatetraenoic acids. (
  • Therefore, these data suggest that in rabbit aorta, arachidonic acid-induced relaxations are mediated by an endothelium-dependent factor (or factors) that differs from the factor (or factors) released by acetylcholine. (
  • When people aren't diagnosed until their teens, it's usually because the narrowing in the aorta is not severe enough to cause serious symptoms until then. (
  • What are the symptoms of coarctation of the aorta? (
  • The following are the most common symptoms of coarctation of the aorta. (
  • The symptoms of coarctation of the aorta may resemble other medical conditions or heart problems. (
  • coarctation of the aorta and bicuspid aortic valve. (
  • Coarctation of the aorta may occur as an isolated defect or in association with various other lesions, most commonly bicuspid aortic valve and ventricular septal defect (VSD). (
  • Bicuspid aortic valve may be seen in nearly two thirds of infants with coarctation of the aorta, whereas only 30% of those who present in childhood have such an anomaly. (
  • About one-third of children with coarctation of the aorta also have a bicuspid aortic valve-a valve that has two leaflets instead of the usual three. (
  • Seventy-five percent of children with coarctation of the aorta also have a bicuspid aortic valve, in which the aortic valve has two leaflets, instead of the usual three. (
  • Can an aneurism of a rupture of the aorta be caused by alcoholism? (
  • Aneurysmal disease of the aorta is clinically important since, as the diameter of the aorta expands, linear wall stress increases, which in turn directly increases the risk of spontaneous aortic rupture-an event with extremely poor prognosis for the patient. (
  • There are several terms which are interchangeably used to describe injury to the aorta such as tear , laceration , transection , and rupture . (
  • As part of the aorta , it is a direct continuation of descending aorta (of the thorax). (
  • Their commitment to research means you may able to participate in clinical trials to advance the diagnosis and treatment of coarctation of the aorta. (
  • The defect occurs when a baby's aorta does not form correctly as the baby grows and develops during pregnancy. (
  • Coarctation of the aorta occurs during the first eight weeks of fetal development, when the heart is forming. (
  • Coarctation of the aorta occurs in a small percentage of children with congenital heart disease. (
  • When a problem occurs with the aorta, the heart and the entire body's blood supply can be jeopardized. (
  • Coarctation of the aorta occurs in about 6 to 8 percent of all children with congenital heart disease, and twice as frequently in boys. (
  • For all intents and purposes, the latter is used when a tear occurs across all or nearly all of the circumference of the aorta . (
  • The earliest physical signs of atherosclerosis are present in the abdominal aorta, and aortic intima-media thickness is considered the best non-invasive measure of structural health of the vasculature in children, suggesting a putative mechanism by which maternal adiposity may influence the risk of later cardiovascular disease in the offspring," they wrote. (
  • The aorta is the main artery that carries blood away from your heart to the rest of your body. (
  • Another way to treat a tortuous aorta is through balloon angioplasty, in which the physician places a catheter into the artery, threads a balloon inside it and inflates the balloon. (
  • Mayo Clinic doctors have expertise in treating coarctation of the aorta with surgical repair and balloon angioplasty. (
  • The aorta is a tube about a foot long and just over an inch in diameter. (
  • The diagnosis of coarctation of the aorta may be missed unless an index of suspicion is maintained, and diagnosis is often delayed until the patient develops congestive heart failure (CHF) , which is common in infants, or hypertension , which is common in older children. (
  • The clinical manifestations and diagnosis of coarctation of the aorta will be reviewed here. (
  • In anatomical sources, the aorta is usually divided into sections. (
  • Coarctation of the aorta is a birth defect in which a part of the aorta is narrower than usual. (
  • Coarctation (pronounced koh-ark-TEY-shun) of the aorta is a birth defect in which a part of the aorta, the tube that carries oxygen-rich blood to the body, is narrower than usual. (
  • Leriche syndrome is an aorta-iliac occlusive disease resulting from thrombotic occlusion of the region just above the abdominal aorta bifurcation (1). (
  • Note that the bifurcation (union) of the inferior vena cava is at L5 and therefore below that of the bifurcation of the aorta. (
  • In more severe cases, where severe coarctations, babies may develop serious problems soon after birth because not enough blood can get through the aorta to the rest of their body. (
  • Nicholas was born with a serious heart defect called critical coarctation of th e aorta , a severe narrowing in his aorta cutting off blood flow to the lower half of his body. (
  • CE-MRA revealed 50% stenosis in the right subclavian artery and 55% stenosis in the left subclavian artery, with long-segment severe stenosis in the abdominal aorta extending into the proximal portion of the bilateral renal artery Mural irregularities and thickening with significant contrast enhancement in the vascular walls were observed on performing CE-MRI, with black blood T1-weighted sequence strongly suggesting vasculitis. (
  • Because the aorta travels from above the heart to below the navel, severe pain may occur at any place along this major vessel. (
  • The aorta also has the thickest walls of any blood vessel in the body. (
  • The aorta is the largest blood vessel in the body. (
  • Think Aorta' is a campaign to lower the unacceptable high rate of misdiagnosed Aortic Dissections in Accident and Emergency Departments and GP Surgeries across the UK and Ireland. (
  • Another system divides the aorta with respect to its course and the direction of blood flow. (
  • A coarctation can affect the body's blood circulation because the left side of the heart has to work harder to pump blood through the narrowed aorta. (
  • The aorta is the principal artery conducting blood from the heart into the systemic circulation . (
  • The aorta distributes oxygenated blood to all parts of the body through the systemic circulation . (
  • Fluorescence emission intensity from a culture of embryonic rat thoracic aorta medial layer ( A-10 line) myoblast cells that were transfected with a pEYFP-Actin plasmid subcellular localization vector. (
  • a large embryonic artery formed by the fusion of the caudal parts of the paired primordial aortae. (