Agents used to treat trichomonas infections.
A genus of parasitic flagellate EUKARYOTES distinguished by the presence of four anterior flagella, an undulating membrane, and a trailing flagellum.
The mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A genus of mushrooms in the family Tricholomataceae, whose species are characterized by a slimy cap (FRUITING BODIES, FUNGAL).
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
The ability to generate new ideas or images.
A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
A chlorinated anilide that is used as an herbicide.
Infections in birds and mammals produced by various species of Trichomonas.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Individuals responsible for various duties pertaining to the medical office routine.
Nurses professionally qualified in administration.
Five membered rings containing a NITROGEN atom.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Drugs used to prevent SEIZURES or reduce their severity.
Substances that reduce the growth or reproduction of BACTERIA.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.

Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. (1/95)

Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb.  (+info)

Intestinal blockage by carcinoma and Blastocystis hominis infection. (2/95)

We detected heavy infections of Blastocystis hominis in four individuals with intestinal obstruction due to cancerous growths. After surgery, the infections spontaneously resolved, without specific chemotherapy. It appears that the B. hominis infection was coincidental and not related to the neoplastic growth. We suggest that intestinal obstruction and concomitant stool retention, plus hemorrhage from cancerous lesions, may have permitted the more abundant growth of B. hominis. This is the first report of a possible relationship between intestinal obstruction and a concomitant B. hominis infection.  (+info)

A new method for assessing metronidazole susceptibility of Giardia lamblia trophozoites. (3/95)

A quantitative, simple, and rapid assay has been developed to assess Giardia lamblia trophozoite sensitivity to metronidazole [1-(2-hydroxyetyl)-2-methyl-5-nitroimidazole] (MTZ). This new assay utilizes the ability of live (surviving) trophozoites to take up oxygen after have been exposed to MTZ. The effect of MTZ on oxygen uptake was compared with its effect on viability as evaluated by a culture method and morphological assays. Oxygen uptake rates decreased in trophozoites treated with MTZ, and this effect was drug concentration dependent: O(2) uptake rates went from 3.04 microM O(2) min(-1) per 10(6) cells to 0.72 microM O(2) min(-1) per 10(6) cells with increasing drug concentration (0.15 to 0.6 mM) in the preincubation. Concentrations of the drug which inhibited oxygen uptake by 28 to 76% in trophozoites killed from 39 to 82% of trophozoites, as evaluated by the culture method, and altered the morphology of 21 to 86% of the trophozoites. Thus, the trophozoites killed by MTZ are nonmotile cells and do not take up oxygen. A good correlation was found between the inhibitory effects of MTZ, as evaluated by oxygen uptake, and cellular viability. Similar 50% inhibitory concentrations were obtained: 0.33 mM by oxygen uptake, 0. 26 mM by the culture method, and 0.35 mM by morphological criteria. Oxygen uptake appears to be a good indicator of parasite viability. Therefore, this new method can provide a convenient means to assess MTZ susceptibility in G. lamblia and can be applied for screening potential antigiardial agents.  (+info)

Resistance of Trichomonas vaginalis to metronidazole: report of the first three cases from Finland and optimization of in vitro susceptibility testing under various oxygen concentrations. (4/95)

Trichomonas vaginalis is a globally common sexually transmitted human parasite. Many strains of T. vaginalis from around the world have been described to be resistant to the current drug of choice, metronidazole. However, only a few cases of metronidazole resistance have been reported from Europe. The resistant strains cause prolonged infections which are difficult to treat. T. vaginalis infection also increases the risk for human immunodeficiency virus transmission. We present a practical method for determining the resistance of T. vaginalis to 5-nitroimidazoles. The suggested method was developed by determining the MICs and minimal lethal concentrations (MLCs) of metronidazole and ornidazole for T. vaginalis under various aerobic and anaerobic conditions. Using this assay we have found the first three metronidazole-resistant strains from Finland, although the origin of at least one of the strains seems to be Russia. Analysis of the patient-derived and previously characterized isolates showed that metronidazole-resistant strains were also resistant to ornidazole, and MLCs for all strains tested correlated well with the MICs. The suggested MICs of metronidazole for differentiation of sensitive and resistant isolates are >75 microg/ml in an aerobic 24-h assay and >15 microg/ml in an anaerobic 48-h assay.  (+info)

A new highly effective short-term therapy schedule for Helicobacter pylori eradication. (5/95)

BACKGROUND: Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%). AIM: To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication. METHODS: A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or 13C urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended. RESULTS: All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects. CONCLUSIONS: The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation.  (+info)

The effectiveness of omeprazole, clarithromycin and tinidazole in eradicating Helicobacter pylori in a community screen and treat programme. Leeds Help Study Group. (6/95)

INTRODUCTION: Helicobacter pylori screening and treatment has been proposed as a cost-effective method of preventing gastric cancer. AIM: To assess, in a randomized controlled trial, the efficacy of therapy in eradicating H. pylori as part of a screening programme, and to report the adverse events associated with this strategy. METHODS: Subjects between the ages of 40-49 years were randomly selected from the lists of 36 primary care centres. Participants attended their local practice and H. pylori status was determined by 13C-urea breath test. Infected subjects were randomized to receive omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. for 7 days (OCT) or identical placebos. Eradication was determined by a 13C-urea breath test 6 months and 2 years after the first visit. Successful eradication was defined as two negative 13C-urea breath tests or one negative and one missing test. Adverse events and compliance were assessed at the 6-month visit. RESULTS: A total of 32 929 subjects were invited to attend, 8407 were evaluable, and 2329 (28%) of these were H. pylori-positive. A total of 1161 subjects were randomized to OCT and 1163 to placebo; over 80% returned for a repeat 13C-urea breath test on at least one occasion. The eradication rates in those allocated to OCT were as follows: intention-to-treat, 710 out of 1161 (61%; 95% confidence interval: 58-64%); evaluable 710 out of 967 (73%; 95% CI: 71-76%); took all medication 645 out of 769 (84%; 95% CI: 81-87%). Adverse events occurred in 45% of the treatment group and in 18% of the placebo group (relative risk 2.5; 95% CI: 2.1-2.9). Compliance, male gender, no antibiotic prescription in the subsequent 2 years and experiencing a bitter taste with the medication were independently associated with treatment success. CONCLUSIONS: The OCT regimen has an eradication rate of 61% in intention-to-treat analysis and is therefore less successful in treating H. pylori as part of a screening programme compared with hospital studies in dyspeptic patients.  (+info)

Cytopathogenic effect of Trichomonas vaginalis on human vaginal epithelial cells cultured in vitro. (7/95)

In this study we established human vaginal epithelial cells (hVECs) in culture and evaluated their interaction with Trichomonas vaginalis parasites to complement previous studies using other cell types. Primary cultures of hVECs were established. Contaminating fibroblasts were separated from epithelial cells by differential trypsinization. Specific antibody staining revealed that over 92% of cells in hVEC monolayers were epithelial cells. T. vaginalis adhered to hVECs and produced severe cytotoxic effects resulting in obliteration of the monolayer within 24 h. Adherence and cytotoxicity were not observed when T. vaginalis was exposed to human vaginal fibroblasts or bovine vaginal epithelial cells. Likewise, the bovine parasite Tritrichomonas foetus had no cytotoxic effects on hVECs. We concluded that the interaction between T. vaginalis and hVECs is both cell specific (limited to epithelial cells and not vaginal fibroblasts) and species specific (limited to human vaginal cells and not bovine cells). Pretreatment of T. vaginalis with metronidazole or periodate abolished the adhesion of parasites to cell monolayers and the cytotoxic effect, suggesting involvement of carbohydrate-containing molecules in these processes. Different clinical isolates of T. vaginalis caused damage to cultured cells at different rates. Parasites separated from the vaginal cell monolayer by a permeable membrane did not produce a cytopathic effect, suggesting contact-dependent cytotoxicity.  (+info)

Molecular epidemiology of metronidazole resistance in a population of Trichomonas vaginalis clinical isolates. (8/95)

Trichomonas vaginalis, the causative agent for human trichomoniasis, is a problematic sexually transmitted disease mainly in women, where it may be asymptomatic or cause severe vaginitis and cervicitis. Despite its high prevalence, the genetic variability and drug resistance characteristics of this organism are poorly understood. To address these issues, genetic analyses were performed on 109 clinical isolates using three approaches. First, two internal transcribed spacer (ITS) regions flanking the 5.8S subunit of the ribosomal DNA gene were sequenced. The only variation was a point mutation at nucleotide position 66 of the ITS1 region found in 16 isolates (14.7%). Second, the presence of a 5.5-kb double-stranded RNA T. vaginalis virus (TVV) was assessed. TVV was detected in 55 isolates (50%). Finally, a phylogenetic analysis was performed based on random amplified polymorphic DNA data. The resulting phylogeny indicated at least two distinct lineages that correlate with the presence of TVV. A band-sharing index indicating relatedness was created for different groups of isolates. It demonstrated that isolates harboring the virus are significantly more closely related to each other than to the rest of the population, and it indicated a high level of relatedness among isolates with in vitro metronidazole resistance. This finding is consistent with the hypothesis that drug resistance to T. vaginalis resulted from a single or very few mutational events. Permutation tests and nonparametric analyses showed associations between metronidazole resistance and phylogeny, the ITS mutation, and TVV presence. These results suggest the existence of genetic markers with clinical implications for T. vaginalis infections.  (+info)

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An antitrichomonal agent is an antiprotozoal agent that acts on trichomonas parasites. Examples include: furazolidone nifuratel ... Agents at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82000994 v t e. ...
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Antimicrob Agents Chemother 1993;37:183-6. *Masumoto M, Hashizume H, Tomishige T, Kawasaki M, Tsubouchi H. OPC-67683, a Nitro- ... a potent antiamoebic and antitrichomonal drug with clear superiority over the standard drug metronidazole (3a) [3]. (1a) and ... Antimicrob Agents Chemother 2009;53:3720-5. *Desjeux P. Leishmaniasis: Current situation and new perspectives. Comp ... Nair MD, Nagarajn K. Nitroimidazoles as chemotherapeutic agents. In: Jucker E, editors. Progress in Drug Research. Vol. 27. ...
  • In addition, the mechanism of the antitrichomonal activity of the BNTX derivatives may differ from that of the standard drug, metronidazole. (bireme.br)
  • Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent ( 13.1 ). (nih.gov)
  • Our earlier extensive foray into the medicinal chemistry of nitroimidazoles resulted in the development of satranidazole (satrogyl ® ), a potent antiamoebic and antitrichomonal drug with clear superiority over the standard drug metronidazole (3a) [ 3 ]. (ijpsonline.com)
  • The Centers for Disease Control and Prevention (CDC) (Atlanta, Georgia, USA) STD Treatment Guidelines recommends the use of a 5-nitroimidazole antimicrobial agent, either metronidazole or tinidazole, for the treatment of T. vaginalis infection ( 8 ). (cdc.gov)
  • Interaction with different medicinal agents The preparation activity will increase when administered in combination with beta-lactam antibiotics, aminoglycosides, vancomycin, clindamycin, metronidazole. (hautes-alpes.net)
  • Metrogyl (metronidazole) is an oral synthetic antiprotozoal and antibacterial agent, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole. (mims.com)
  • Strains of T. vaginalis differ also in susceptibility to metronidazole, the major antitrichomonal drug. (beds.ac.uk)
  • Metronidazole 443-48-1 C6H9N3O 171.16 white or yellowish crystal or crystalline powder 93-107% anti-amebic, antitrichomonal drug and anti-anaerobe drug 25kg/carton drum Zhejiang Chenxin Technology Co., Ltd. is dedicated to the research and developmen. (worldbid.com)
  • They were assigned to guideline-recommended treatment with either azithromycin or doxycycline alone or with a single 2-g dose of tinidazole , an antitrichomonal agent, in order to test the hypothesis that adding the second agent would boost cure rates. (thefreedictionary.com)
  • Tinidazole is a nitroimidazole antitrichomonal agent effective against trichomonas infections. (pharmacy2home.com)
  • Agents used to treat trichomonas infections. (bvsalud.org)
  • A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. (nih.gov)
  • The following attributes have made it clear that it should be considered as broad spectrum antifungal and antitrichomonal actions. (cadasb.org)
  • An antitrichomonal agent is an antiprotozoal agent that acts on trichomonas parasites. (wikipedia.org)
  • It act as an anti-infective and an antitrichomonal agent, which is an antiprotozoal agent that acts on trichomonas parasites. (2beingfit.com)
  • Trichomonas vaginalis is the causative agent of trichomoniasis, which is one of the most common sexually transmitted diseases worldwide. (biomedcentral.com)
  • Detection and characterization of serum antitrichomonal antibodies in urogenital trichomoniasis. (asm.org)
  • The level of antibodies of the immunoglobulin A class was higher in patients with past records of trichomoniasis, but less significantly so than the total antitrichomonal antibody level. (asm.org)
  • Other factors that may increase the incidence of VVC include the use of douches, perfumed feminine hygiene sprays, topical antimicrobial agents, and tight, poorly ventilated clothing and underwear. (diagnose-me.com)
  • Many researchers have reported in vitro and in vivo evidence to support various plant materials as topical anti-microbial agents to enhance wound healing 5 . (openaccesspub.org)
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  • Various antitrichomonal drugs or dosages were eligible, as were comparisons of treatment with no treatment or placebo. (aafp.org)
  • Antitrichomonal drugs may produce such disorders as dehydration, fever, infection, and cytochrome P450 enzymes in the following hypothyroidism in the. (udisco.com)
  • The more often the penetration of antimicrobial agents into the tissue of the prostate transcanalicular in - emissaries through the channels of the gland, the opening in the rear wall of the urethra. (prostero-official.eu)
  • The class of nitroimidazoles includes compounds that are important antiparasitic agents, which have a broad spectrum of action and high biological activity. (scielo.br)
  • Increasing numbers of multidrug-resistant strains of S pneumoniae in the United States and Europe, the decline in H influenzae type b because of current vaccination strategies, and increasing recognition of nontypeable H influenzae as etiologic agents of pneumonia have prompted reconsideration of the drug of choice. (statescale.tk)
  • Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. (bireme.br)
  • The 7-benzylidenenaltrexone (BNTX) derivatives 2a-v, 3a-c, 13a-c, and 14a were synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. (bireme.br)
  • A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases. (semanticscholar.org)
  • The structure-activity-relationship studies found that 4-iodo-BNTX (2g) showed the highest activity (IC =10.5 M) and the affinity for the opioid receptor was less important for antitrichomonal activity against Trichomonas vaginalis. (bireme.br)
  • Our results showed that PFUR 4a and 4b are promising molecules that can be used for the development of new trichomonacidal agents for T. vaginalis . (biomedcentral.com)
  • Conclusion: Findings demonstrate the potential of Rheum ribes extracts as an anti-trichomonas agent for human use. (ac.ir)
  • The 2 principal metabolites result from oxidation of side chains, both have antitrichomonal activity. (mims.com)
  • Imidazole analogs have proved to be a very good source of medicinal agents. (intechopen.com)
  • For instance, in the last decades, there was increased pharmacological evaluation of medicinal plants that could be of benefit as contraceptive and fertility control agents as many plants were known to have promising contraceptive properties among others 4 . (ijpjournal.com)
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  • Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F. Traditional medicine as a source of new therapeutic agents against psoriasis. (koreascience.or.kr)
  • The spermostatic and microbicidal actions of quinones and maleimides: toward a dual-purpose contraceptive agent. (ac.ir)
  • The use of the sponge as a contraceptive is enhanced by incorporating into the sponge a spermicidal agent as, for example, a copper salt. (justia.com)
  • An antitrichomonal agent which is effective either topically or orally and whose urinary metabolites are also trichomonicidal. (bireme.br)
  • G. kola seed is used as an antipyretic agent in indigenous system of medicine. (ijpjournal.com)
  • The morphinan skeleton bearing both the double bond for a Michael acceptor and the phenolic hydroxy group would be a specific template for development of antitrichomonal agents. (bireme.br)
  • naturally occurring chelating agents may play an important role in sequestrating heavy metals which in turn may reduce metal induced free radicals generation. (ijpsr.com)
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  • https://dx.doi.org/10.2305/IUCN.UK.2021-1.RLTS.T60330325A60330335.en. (wikipedia.org)
  • 3. Ragheb A, Attia A, Eldin WS, Elbarbry F., Gazarin S, Shoker A. The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review. (ac.ir)
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