Antithyroid Agents
Methimazole
Propylthiouracil
Carbimazole
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Hyperthyroidism
Thyrotoxicosis
A hypermetabolic syndrome caused by excess THYROID HORMONES which may come from endogenous or exogenous sources. The endogenous source of hormone may be thyroid HYPERPLASIA; THYROID NEOPLASMS; or hormone-producing extrathyroidal tissue. Thyrotoxicosis is characterized by NERVOUSNESS; TACHYCARDIA; FATIGUE; WEIGHT LOSS; heat intolerance; and excessive SWEATING.
Immunoglobulins, Thyroid-Stimulating
Thyroid Gland
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
Thyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Hypothyroidism
Thyrotropin
A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
Thiouracil
Receptors, Thyrotropin
Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).
Triiodothyronine
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Thyroiditis, Autoimmune
Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.
Thyroid Hormones
Iodine Radioisotopes
Thyroiditis
Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.
Goiter
Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Autoantibodies
Hashimoto Disease
Methylthiouracil
Iodide Peroxidase
Perchlorates
Dermatitis, Exfoliative
The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)
Nephrotic Syndrome
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Anemia, Aplastic
Pruritus
Bacteriology
Ophthalmology
Drug Information Services
Graves Ophthalmopathy
Exophthalmos
Taste Threshold
Taste
Taste Perception
Taste Buds
Feeding Behavior
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Publishing
MEDLINE
Serial Publications
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (1/466)
We describe a patient who presented with Wegener's granulomatosis associated with antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) with a cytoplasmic immunofluorescence pattern (cANCA), whose ANCA type changed to antimyeloperoxidase antibodies with a perinuclear immunofluorescence pattern (pANCA) when treated with propylthiouracil, and changed back to anti-PR3 antibodies with cANCA after the medication was discontinued. The patient developed flares of vasculitis symptoms associated with rises in either type of ANCA. Tests for antimyeloperoxidase ANCA were repeatedly negative before the drug was started, strongly implicating the drug as the cause of the episode. This case demonstrates that patients with idiopathic ANCA-positive vasculitis may quickly develop a superimposed drug-associated ANCA-positive vasculitis. Iatrogenic vasculitis should be suspected when a patient with idiopathic vasculitis with one type of ANCA develops the other type of ANCA. (+info)Screening methods for thyroid hormone disruptors. (2/466)
The U.S. Congress has passed legislation requiring the EPA to implement screening tests for identifying endocrine-disrupting chemicals. A series of workshops was sponsored by the EPA, the Chemical Manufacturers Association, and the World Wildlife Fund; one workshop focused on screens for chemicals that alter thyroid hormone function and homeostasis. Participants at this meeting identified and examined methods to detect alterations in thyroid hormone synthesis, transport, and catabolism. In addition, some methods to detect chemicals that bind to the thyroid hormone receptors acting as either agonists or antagonists were also identified. Screening methods used in mammals as well as other vertebrate classes were examined. There was a general consensus that all known chemicals which interfere with thyroid hormone function and homeostasis act by either inhibiting synthesis, altering serum transport proteins, or by increasing catabolism of thyroid hormones. There are no direct data to support the assertion that certain environmental chemicals bind and activate the thyroid hormone receptors; further research is indicated. In light of this, screening methods should reflect known mechanisms of action. Most methods examined, albeit useful for mechanistic studies, were thought to be too specific and therefore would not be applicable for broad-based screening. Determination of serum thyroid hormone concentrations following chemical exposure in rodents was thought to be a reasonable initial screen. Concurrent histologic evaluation of the thyroid would strengthen this screen. Similar methods in teleosts may be useful as screens, but would require indicators of tissue production of thyroid hormones. The use of tadpole metamorphosis as a screen may also be useful; however, this method requires validation and standardization prior to use as a broad-based screen. (+info)Risk of iodine-induced thyrotoxicosis after coronary angiography: an investigation in 788 unselected subjects. (3/466)
In this study, the risk of iodine-induced thyrotoxicosis in unselected patients from an iodine-deficient area was investigated. The patients were consecutively enrolled. Thyroid hormone values and urinary iodine excretion were determined before, as well as 1, 4 and 12 weeks after iodine contamination by coronary angiography. Two of 788 unselected patients developed hyperthyroidism within 12 weeks. The two patients did not belong to a risk group for iodine-induced thyrotoxicosis (i.e. old people, patients with goiter or possible thyroid autonomy, low TSH). Both patients had normal TSH levels at baseline and ultrasound of the thyroid was without evidence of nodules. The study shows that in euthyroid unselected patients from an iodine-deficient area short-term iodine contamination by contrast media rarely leads to hyperthyroidism. On account of these facts, prophylactic therapy, e.g. by perchlorate or thiamazole, is not generally recommended, because the risk of side-effects is perhaps even greater than the risk of iodine-induced thyrotoxicosis. (+info)Identification of thyroid hormone residues on serum thyroglobulin: a clue to the source of circulating thyroglobulin in thyroid diseases. (4/466)
Thyroglobulin (Tg) present in the serum of normal individuals and patients with thyroid disorders could be partly newly synthesized non-iodinated Tg and partly Tg containing iodine and hormone residues originating from the lumen of thyroid follicles. With the aim of examining the contribution of the latter source of Tg to the elevation of serum Tg concentration in thyroid pathophysiological situations, we devised a procedure to identify thyroxine (T4) and tri-iodothyronine (T3) residues on Tg from unfractionated serum. A two-step method, basedon (i)adsorption of Tg on an immobilized anti-human Tg (hTg) monoclonal antibody (mAb) and (ii)recognition of hormone residues on adsorbed Tg by binding of radioiodinated anti-T4 mAb and anti-T3 mAb, was used to analyze serum Tg from patients with either Graves' disease (GD), subacute thyroiditis (ST) or metastatic differentiated thyroid cancer (DTC). Purified hTg preparations with different iodine and hormone contents were used as reference. Adsorption of purified Tg and serum Tg on immobilized anti-hTg mAb ranged between 85 and 90% over a wide concentration range. Labeled anti-T4 and anti-T3 mAbs bound to adsorbed purified Tg in amounts related to its iodine content. Tg adsorbed from six out of six sera from ST exhibited anti-T4 and anti-T3 mAb binding activities. In contrast, significant mAb binding was only observed in one out of eight sera from untreated GD patients and in 1 out of 13 sera from patients with DTC. The patient with DTC, whose serum Tg contained T4 and T3, represented a case of hyperthyroidism caused by a metastatic follicular carcinoma. In conclusion, we have identified, for the first time, T4 and T3 residues on circulating Tg. The presence of Tg with hormone residues in serum is occasional in GD and DTC but is a common and probably distinctive feature of ST. (+info)Improved suppression by dietary taurine of the fecal excretion of bile acids from hypothyroid rats. (5/466)
The effect of dietary taurine, 2-aminoethanesulfonic acid, on hypercholesterolemia caused by thiouracil-induced hypothyroidism was investigated in hypothyroid rats. Serum total- and HDL-cholesterol were significantly increased, and the excretion of fecal bile acids was significantly decreased. Taurine did not change the hypercholesterolemia, but significantly recovered the excretion of bile acids. (+info)Effects of oral propylthiouracil treatment on nitric oxide production in rat aorta. (6/466)
The effects of oral propylthiouracil (PTU) treatment on vascular nitric oxide (NO) production were studied in the rat aorta. Rats were fed a standard low fat diet with or without 0.1% PTU, for 2 or 4 weeks, or for 2 weeks with additional thyroxine injections. Concentration response curves were then constructed to phenylephrine (PE) in both endothelium-intact and denuded aortic rings from these animals and after incubation with 0.1 mM L-N(G)nitroarginine (L-NOARG). In addition, expression of nitric oxide synthase (NOS) was analysed in sections of aorta from PTU-treated and control rats using rabbit polyclonal antibodies to both inducible NOS (iNOS) and endothelial NOS (eNOS). Oral PTU treatment resulted in a significant reduction in both the maximum response (control, 0.53+/-0.02; 2 week PTU, 0.20+/-0.07; 4 week PTU, 0.07+/-0.02 g mg(-1)) and vessel sensitivity (EC50 values: control, 9.10x10(-8)+/-0.67; 2 week PTU, 7.45x10(-7)+/-1.15; 4 week PTU, 9.73x10(-7)+/-0.45 M) to PE in endothelium-intact vessel rings, as compared to controls (P<0.05). Both endothelial removal and incubation with L-NOARG restored the maximum response after 2, but not 4 weeks, although, in general, vessel sensitivity was not altered by either treatment. Vessels from PTU-treated rats given thyroxine injections showed no significant differences between any of the dose response curve parameters. Immunohistochemical analysis suggested that labelling for eNOS may be increased after PTU treatment as compared to control animals, whereas iNOS antibody immunoreactivity was not different between the two groups. These results suggest that the hyporesponsiveness to PE observed after oral PTU treatment is, in part, due to enhanced nitric oxide (NO) production by the endothelium, and demonstrate for the first time that thyroid hormones may play a role in the regulation of eNOS activity in the rat aorta. (+info)Remission of insulin autoimmune syndrome in a patient with Grave's disease by treatment with methimazole. (7/466)
The patient, a 24-year-old man, had suffered from hunger, sweating, tachycardia and palpitation for three years. He was diagnosed as having Graves' disease (GD) and treated with methimazole (MMI) for 3 months. He noted that palpitation and perspiration seemed to particularly occur when he was hungry, and thus he was examined to determine whether these symptoms were caused by hypoglycemia. As a markedly elevated immunoreactive insulin level and the presence of insulin antibody in serum were found, he was diagnosed as having insulin autoimmune syndrome (IAS). HLA typing revealed the patient to be positive for group Bw62/Cw4/DR4, which is reportedly a specific HLA type in MMI-treated euthyoroid GD patients with IAS. In spite of the continuation of MMI treatment, the % binding of IRI decreased and the hypoglycemic episode disappeared. In contrast to the previously reported MMI induced IAS in GD cases, MMI is unlikely to have exacerbated IAS in the present case, although his HLA combination is identical to that of the previous cases. (+info)Hypercalcemia accompanied by hypothalamic hypopituitarism, central diabetes inspidus and hyperthyroidism. (8/466)
We present here a case of prominent hypercalcemia accompanied by hypothalamic tumor and Graves' disease. A 24-year-old man with hypothalamic tumor showed hypopituitarism, central diabetes inspidus (DI) and hyperthyroidism. Nausea, loss of thirst and appetite, and general fatigue were found with the unveiling of hypercalcemia and hypernatremia. Parathyroid hormone (PTH) and 1alpha-dihydroxyvitamin D levels were suppressed with a normal range of PTH-related protein values. One-desamino-(8-D-arginine)-vasopressin (DDAVP) and half-saline administration normalized hypernatremia, while hypercalcemia was still sustained. Administration of cortisone acetate and thiamazole reduced the elevated serum Ca level. In the present case, concurrent hyperthyroidism was assumed to accelerate skeletal mobilization of calcium into the circulation. Hypocortisolism and central DI was also considered to contribute, to some extent, to the hypercalcemia through renal handling of Ca. (+info)
Antithyroid agent - Wikipedia
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Antithyroid Medications for Graves Disease
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Halocarbon
Prior to 1940, iodides were the predominant antithyroid agents. In large doses, iodides inhibit proteolysis of thyroglobulin, ...
Thyroid peroxidase
Nagasaka A, Hidaka H (Jul 1976). "Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human ... Chardès T, Chapal N, Bresson D, Bès C, Giudicelli V, Lefranc MP, Péraldi-Roux S (Jun 2002). "The human anti-thyroid peroxidase ... with such antibodies being called anti-thyroid peroxidase antibodies (anti-TPO antibodies). This is most commonly associated ...
2-Thiouracil
ISBN 978-3-11-015714-7. Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2- ... Its use in recent times has been replaced by advent of more potent and safer antithyroid drugs. It occurs in seeds of Brassica ... The substance is a historically relevant anti-thyroid preparation. Astwood E.B. used it in 1943 as therapy of Graves' disease ... Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been ...
Causes of autism
... utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. ... Teratogens are environmental agents that cause birth defects. Some agents that are theorized to cause birth defects have also ... Possible environmental agents include flavonoids in food, tobacco smoke, and most herbicides. This hypothesis has not been ... Autism has been linked to birth defect agents acting during the first eight weeks from conception, though these cases are rare ...
Potassium perchlorate
... can be used as an antithyroid agent used to treat hyperthyroidism, usually in combination with one other ...
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He has done many clinical trials including the one on a compound developed by him for use as an anti-thyroid agent. He has also ...
Propylthiouracil
... while the antithyroid agent methimazole is substantially less protein bound. However, both are equally transferred across the ... X. Antithyroid Compounds. Synthesis of 5- and 6- Substituted 2-Thiouracils from β-Oxoesters and Thiourea". Journal of the ... Propylthiouracil is in the antithyroid family of medications. It works by decreasing the amount of thyroid hormone produced by ... propylthiouracil is no longer recommended in non-pregnant adults and in children as the front line antithyroid medication. One ...
List of MeSH codes (D27)
... antithyroid agents MeSH D27.505.696.399.450.360 - estrogen receptor modulators MeSH D27.505.696.399.450.360.315 - estrogen ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Glucosinolate
... mainly as goitrogens and anti-thyroid agents) in both humans and animals[failed verification] at high doses. However, tolerance ...
Basal metabolic rate
The metabolic rate can be affected by some drugs, such as antithyroid agents, drugs used to treat hyperthyroidism, such as ...
ATD
... estrogen inhibitor Acute tryptophan depletion Anti-thyroid drugs or antithyroid agent ATD Fourth World Against the Day, a ...
Antithyroid agent
An antithyroid agent is a hormone antagonist acting upon thyroid hormones. The main antithyroid drugs are carbimazole (in the ... A less common antithyroid agent is potassium perchlorate. In Graves' disease, treatment with antithyroid medications must be ... Antithyroid agents at the US National Library of Medicine Medical Subject Headings (MeSH). ... H03B code of antithyroid preparations Homsanit M, Sriussadaporn S, Vannasaeng S, Peerapatdit T, Nitiyanant W, Vichayanrat A ( ...
Antiemetic
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These ...
Analgesic
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or ...
Stimulant
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... It may be used as a nasal/sinus decongestant, as a stimulant,[119] or as a wakefulness-promoting agent.[120] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... and anorectic agent.[112] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ...
Decongestant
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... List of agents[edit]. Adrenaline releasing agents[edit]. Main article: Norepinephrine releasing agent ... 3 List of agents *3.1 Adrenaline releasing agents *3.1.1 Common or widely marketed ... since these agents lose effectiveness after a few days. ...
Antifungal
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... "Dermatotherapeutic Agents". Ullmann's Encyclopedia of Industrial Chemistry (7th ed.). 2007. doi:10.1002/14356007.a08_301.pub2. ... Kyriakidis I, Tragiannidis A, Munchen S, Groll AH (February 2017). "Clinical hepatotoxicity associated with antifungal agents ... "The cost effectiveness of testing for onychomycosis versus empiric treatment of onychodystrophies with oral antifungal agents ...
Proton-pump inhibitor
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Within the class of medications, there is no clear evidence that one agent works better than another.[1][2] ... In British Columbia, Canada the cost of the PPIs varies significantly from 0.20 CAD to 2.38 CAD per dose while all agents in ... The cost between different agents varies significantly.[1] ...
Diuretic
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... Diuretics increase the urine volume and dilute doping agents and their metabolites. Another use is to rapidly lose weight to ...
Local anesthetic
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure,[56] although since cholinesterases are produced in ...
Medication
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
Immunosuppressive drug
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs ...
Immunosuppressive drug
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of ...
Dissociative
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Bronchodilator
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... "Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review" (PDF). Respiratory Care. 60 ...
Depressant
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ...
Statin
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... LDL-lowering potency varies between agents. Cerivastatin is the most potent, (withdrawn from the market in August, 2001 due to ... Thurnher M, Nussbaumer O, Gruenbacher G (July 2012). "Novel aspects of mevalonate pathway inhibitors as antitumor agents". ... The first agent they identified was mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum. ...
Muscle relaxant
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... "centrally acting agents",[10] but adds a distinct category of "directly acting agents", for dantrolene.[11] Use of this ... Several of these agents also have abuse potential, and their prescription is strictly controlled.[22][23][24] ... However, it is now known not every agent in this class has CNS activity (e.g. dantrolene), so this name is inaccurate.[5] ...
Stimulant
Thyroid hormones / Antithyroid agents. infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... It may be used as a nasal/sinus decongestant, as a stimulant,[116] or as a wakefulness-promoting agent.[117] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... Amphetamine is a norepinephrine-dopamine releasing agent (NDRA). It enters neurons through dopamine and norepinephrine ...
Medication
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... antithyroid drugs, calcitonin, diphosponate, vasopressin analogues ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
Glucosinolate
... mainly as goitrogens and anti-thyroid agents) in both humans and animals[failed verification] at high doses.[9] However, ...
Iodine-131
Meta-[I-131]iodobenzylguanidine is a radio-labeled analog of the adrenergic blocking agent guanethidine.[37] Radioactivity is ... Antithyroid drugs. *Fission products. *Radioactive contamination. Hidden categories: *CS1 maint: DOI inactive as of January ...
Chemotherapy
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ...
WHO Model List of Essential Medicines
18.6 Thyroid hormones and antithyroid medicines. *19 Immunologicals *19.1 Diagnostic agents. *19.2 Sera and immunoglobulins ... Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ... Diagnostic agents[edit]. *Tuberculin, purified protein derivative (PPD). Sera and immunoglobulins[edit]. *Antivenom ... single agent trimethoprim may be an alternative for lower urinary tract infection. ...
甲狀腺功能亢進症 - 維基百科,自由的
Antithyroid agent)藥可以暫時對病患有所幫助。另一種治療方式是手術去除甲狀腺,此方式可用於甲狀
Thyroid hormones
Anti-thyroid drugs[edit]. Iodine uptake against a concentration gradient is mediated by a sodium-iodine symporter and is linked ... The hormones T4 and T3 are the biologically active agents central to metabolic regulation.[citation needed] ... perchlorates are used as ionic inhibitors in anti thyroid compounds ...
Basal metabolic rate
The metabolic rate can be affected by some drugs, such as antithyroid agents, drugs used to treat hyperthyroidism, such as ...
Graves' disease
Antithyroid drugs[edit]. The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/ ... Agents that act as antagonists at thyroid stimulating hormone receptors are currently under investigation as a possible ... Treatment with antithyroid medications must be given for six months to two years to be effective. Even then, upon cessation of ... A positive TSHR-Ab at the end of antithyroid drug treatment increases the risk of recurrence to 90% (sensitivity 39%, ...
Thyroid
Graves' disease is treated with anti-thyroid drugs such as propylthiouracil, which decrease the production of thyroid hormones ... Among amphibians, administering a thyroid-blocking agent such as propylthiouracil (PTU) can prevent tadpoles from ...
Hyperthyroidism
Antithyroid drugsEdit. Thyrostatics (antithyroid drugs) are drugs that inhibit the production of thyroid hormones, such as ... an iodinated radiocontrast agent or an iodine solution if the radiocontrast agent is not available, and an intravenous steroid ... Measuring specific antibodies, such as anti-TSH-receptor antibodies in Graves' disease, or anti-thyroid peroxidase in ... disease resistant to antithyroid drugs". Hellenic Journal of Nuclear Medicine. 8 (3): 158-61. PMID 16390021.. ...
Pharmacology
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... This network is made up of protein-protein interactions from Treponema pallidum, the causative agent of syphilis and other ... Targets in synapses can be modulated with pharmacological agents. In this case, cholinergics (such as muscarine) and ...
Disease-modifying antirheumatic drug
Thyroid hormones/Antithyroid agents. Infections and. infestations (J, P, QI). *Antimicrobials: Antibacterials ( ... Although these agents operate by different mechanisms, many of them can have similar impact upon the course of a condition.[6] ... which refers to agents that treat the inflammation but not the underlying cause) and steroids (which blunt the immune response ...
Antithyroid agent - Wikipedia
An antithyroid agent is a hormone antagonist acting upon thyroid hormones. The main antithyroid drugs are carbimazole (in the ... A less common antithyroid agent is potassium perchlorate. In Graves disease, treatment with antithyroid medications must be ... Antithyroid agents at the US National Library of Medicine Medical Subject Headings (MeSH). ... H03B code of antithyroid preparations Homsanit M, Sriussadaporn S, Vannasaeng S, Peerapatdit T, Nitiyanant W, Vichayanrat A ( ...
Radioactive Iodine Uptake Testing Medication: Antithyroid Agent
Antithyroid agent Oral, Rectal Advanced Patient Information - Drugs.com
Detailed drug Information for antithyroid agent Oral, Rectal. Includes common brand names, drug descriptions, warnings, side ... While you are being treated with antithyroid agents, and after you stop treatment with it, do not have any immunizations ( ... Antithyroid agents may lower your bodys resistance and there is a chance you might get the infection the immunization is meant ... Antithyroid agent. Class Name: antithyroid agent (Oral route, Rectal route). Commonly used brand name(s). ...
Goitrogens-anti Thyroid Agents | Indusladies
GOITROGENS-ANTI THYROID AGENTS Iodine is an essential micro nutrient for all animal species & iodine deficiency is among the ... GOITROGENS-ANTI THYROID AGENTS. Iodine is an essential micro nutrient for all animal species & iodine deficiency is among the ... Goitrogens-anti Thyroid Agents Discussion in Indian Diet & Nutrition started by MOKSHA GUPTA, Nov 12, 2007. ... A large number of food stuffs possess anti-thyroid agents collectively designated as Goitrogens.. Depending upon the level of ...
Graves Disease Medication: Antithyroid agents, Beta-adrenergic blocker, Iodines, Bile acid sequestrants, Antidepressants,...
Antithyroid agents. Class Summary. Thioamides function as antithyroid agents mainly by inhibiting iodide organification and ... Now primarily used as a backup agent when other first-line agents are contraindicated because of hypersensitivity or toxicity. ... Oral contrast agents ipodate or iopanoic acid also shown to be potent inhibitors of T4-to-T3 conversion, making them ideal for ... Although these agents fall under pregnancy category D, they have been used safely in many pregnant patients. Retrospective ...
Molecules | Free Full-Text | Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives...
... and follow up experiments will be needed to confirm the use of the designed compounds as new potential antithyroid agents. ... more antithyroid activity. Most of the designed compounds show superiority over PTU in reducing the mean serum T4 levels of ... One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of ... One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of ...
Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish. - Webbased Archive of RIVM...
Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.. Authors:. Ven, Leo T M van der ... Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.. en. ... Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish. ...
Synthesis of Some Novel Derivatives of 2-(9H-purin-6-ylsulfanyl) Acetohydrazide as Potential Antithyroid Agents
Acetohydrazide as Potential Antithyroid Agents. J. Mex. Chem. Soc [online]. 2012, vol.56, n.4, pp.362-368. ISSN 1870-249X. ... Keywords : Hyperthyroidism; Antithyroid activity; Hydrazides; In vitro activity; In vivo Activity. · abstract in Spanish · text ... The antithyroid effect of these compounds was ascertained in vitro by studying their complexation with iodine ... In vivo, the hormonal as well as histological variations in male Wistar rats demonstrated significant antithyroid potential (p ...
Antithyroid Drug
... , Thioamide, Thionamide, Propylthiouracil, PTU, Methimazole, Tapazole. ... Agents, Antithyroid, Antithyroid Agents, THYROID ANTAG, ANTITHYROID AGENTS, anti-thyroid agents, anti-thyroid agents ( ... antithyroid agent, Antithyroid preparation, NOS, Thyroid inhibitor preparation, NOS, Antithyroid Agent, Antithyroid agent ( ... ANTITHYROID AGENTS, antithyroid drug, inhibitors thyroid, antithyroid agents, antithyroid preparations, antithyroid drugs, ...
Thiamazole
-
Antithyroid Agents, ATC:H03B
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression ...
Thiuragyl
-
Antithyroid Agents, Antimetabolites, ATC:H03BA02
PTU® Antithyroid Agent x100 Tablets | OKDERMO® Skin Care
Antithyroid Agent tablets that works by preventing the thyroid gland from producing too much of the thyroid hormone. ... Shop » Supplements » Thyroid Extract Supplements » PTU® Antithyroid Agent x100 Tablets. Home / Supplements / Thyroid Extract ... Be the first to review "PTU® Antithyroid Agent x100 Tablets" Cancel reply. Your email address will not be published. Required ... PTU Tablet belongs to a group of medicine called anti-thyroid agents. It is used in the treatment of hyperthyroidism. It works ...
Endocrinology - Drugs| Medindia
WHO HQ Library catalog ›
Results of search for 'su:{Antithyroid agents}'
Some thyrotropic agents. by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans : Some Thyrotropic Agents Lyon ... Some anti-thyroid and related substances, nitrofurans and industrial chemicals / this publication represents the views of two ... some Anti-Thyroid and Related Substances Lyon, France) (1974 : ... Results of search for su:{Antithyroid agents} Refine your ...
Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in...
Hypoglycemic Agents / administration & dosage * Hypoglycemic Agents / pharmacology* * Lipid Peroxidation / drug effects * Plant ... Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in ... Compared with the standard antithyroid drug, propylthiouracil, scopoletin exhibited a superior therapeutic activity, since ...
Drug-induced hair loss - Regrowth. Your Source Of Hair News
Melphalan facts, information, pictures | Encyclopedia.com articles about Melphalan
melphalan (mel-fă-lan) n. an alkylating agent administered by mouth or injection to treat various types of cancer, particularly ... Melphalan is an anticancer (antineoplastic) agent. It also acts as a suppressor of the immune system. It is available under the ... Melphalan is a nitrogen mustard derivative and belongs to the group of alkylating anticancer agents. It chemically interferes ...
Drug-induced ocular side effects (Book, 2001) [WorldCat.org]
Antithyroid agents. Erectile dysfunction agent. Estrogens and progestogens. Ovulatory agents. Thyroid hormones --. 8. Agents ... Antifungal agents. Antileprosy agents. Antimalarial agents. Antiprotozoal agents. Antitubercular agents --. 2. Agents affecting ... Antifungal agents. Antileprosy agents. Antimalarial agents. Antiprotozoal agents. Antitubercular agents -- 2. Agents affecting ... Antithyroid agents. Erectile dysfunction agent. Estrogens and progestogens. Ovulatory agents. Thyroid hormones -- 8. Agents ...
Thioguanine | Encyclopedia.com
Propylthiouracil Advanced Patient Information - Drugs.com
Drug class: antithyroid agents. Consumer resources. *Propylthiouracil. Professional resources. *Propylthiouracil (AHFS ... Propylthiouracil is an antithyroid medicine. It works by making it harder for the body to use iodine to make thyroid hormone. ... Propylthiouracil may be the preferred treatment when an antithyroid drug is indicated during or just prior to the first ...
The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy - Full Text View - ClinicalTrials.gov
Antithyroid Agents. Antimetabolites. Molecular Mechanisms of Pharmacological Action. Hormone Antagonists. Hormones, Hormone ... All patients will be treated with antithyroid drug until TSH levels of the patients are between 0.4-1. During this period all ... Active Comparator: Anti-thyroid drug Drug: Propylthiouracil 150-600 mg in two-three divided doses ... anti-thyroid peroxidase and anti-thyroglobulin levels will be measured in 3 months intervals for a period of 12 months. ...
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste - Full Text View - ClinicalTrials.gov
Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves' disease: national long-term...
Antithyroid Agents / adverse effects * Antithyroid Agents / pharmacology * Antithyroid Agents / therapeutic use* * Child ... Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves disease: national long-term ... Definitive treatment was performed in cases of poor compliance with antithyroid drug (ATD) treatment, thyrotoxicosis relapse, ...
Similar articles for PubMed (Select 22892501) - PubMed - NCBI
Fever due to antithyroid agents].. Shamelian SO, Nortier JW.. Ned Tijdschr Geneeskd. 1999 Jan 30;143(5):225-8. Dutch. ... Antithyroid drug-induced agranulocytosis. A rare but dreaded condition].. Lehtihet M, Zedenius J, Helldén A, Axelsson R, ... Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis.. Dai WX, Zhang JD, Zhan SW, Xu BZ, Jin H ... Characteristics of agranulocytosis as an adverse effect of antithyroid drugs in the second or later course of treatment. ...
Current Updates on Oxazolidinone and Its Significance
9) Antithyroid Agent [81]. 5-Vinyloxazolidine-2-thione (VOT) administered orally to lactating rats was found to be efficiently ... a novel oxazolidinone antibacterial agent," in Proceedings of the Interscience Conference on Antimicrobial Agents and ... C. W. Ford et al., in Proceedings of the 35th Internscience Conference on Antimicrobial Agents and Chemotherapy, 1995. ... have reported isoxazolidinone agents having various substitutions at the C-region and most of the compounds have been found to ...
The Recurrence Rate of Graves' Disease among Patients with Subclinical Thyrotoxicosis after Initial Remission with Antithyroid...
... treatment with antithyroid agents who then developed subclinical thyrotoxicosis after discontinuation of antithyroid agents. ... Antithyroid Agents , Diagnosis , Drug Therapy , Endocrinology , Female , Follow-Up Studies , Graves Disease , Humans , Male , ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Antithyroid Agents / Thyrotoxicosis / Female / ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Antithyroid Agents / Thyrotoxicosis / Female / ...
Hypothyroidism Versus Hyperthyroidism | Fox News
Medication Use by Medicare Beneficiaries Living in Nursing Homes and Assisted Living Facilities | ASPE
Insulin and Anti-Diabetic Agents. 16.7. 92.9. 15.8. 93.2. Thyroid and Antithyroid Agents. 14.2. 95.2. 16.3. 96.6. ... Cholesterol and Triglyceride Lowering Agents. 2.6. 76.0. 5.4*. 81.3. Ear/Eye/Nose/Rectum/Topical/Vagina/Other. 49.6. 64.4. 44.2 ... Anti-Cancer Agents. 4.0. 65.0. 2.8*. 76.3. SOURCE: Medicare Current Beneficiary Survey, Institutional Drug File, 1998.* ... Use of cardiovascular agents such as ace-inhibitors, cardiac stimulants, and calcium channel blockers are also similar in both ...
Propylthiouracil (PTU) Drug Information - Indications, Dosage, Side Effects and Precautions
PropylthiouracilHyperthyroidismMethimazoleCarbimazoleTreated with antithyroid drugsDrugsPotential antithyroidIodineThioureaMedicationMedicationsRelapseThiouracilDiscontinuationSubstancesThyrotoxicosisRemissionCorticosteroidsIodideGravesAntifungalAntipsychoticDerivativesPregnancyAdrenalHormonesPotassiumAnti-thyroid agentCompoundsTreatmentClassAntineoplasticAntihypertensive agentsConcentrationsChemicalAntiprotozoalAntiarrhythmicAnticancerMechanisms
Propylthiouracil7
- The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU. (wikipedia.org)
- Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish. (openrepository.com)
- Propylthiouracil is a thiourea antithyroid agent. (pharmacycode.com)
- Compared with the standard antithyroid drug, propylthiouracil, scopoletin exhibited a superior therapeutic activity, since unlike propylthiouracil, it also inhibited hepatic lipid peroxidation. (nih.gov)
- Propylthiouracil is an antithyroid medicine. (drugs.com)
- Propylthiouracil is in a class of medications called antithyroid agents. (medlineplus.gov)
- Propylthiouracil is an antithyroid agent, a thioamide. (patientslikeme.com)
Hyperthyroidism5
- Doctors generally treat hyperthyroidism with anti-thyroid agents. (foxnews.com)
- This medication is an antithyroid agent, prescribed for hyperthyroidism. (medindia.net)
- Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution. (drugbank.ca)
- These immune and clinical peculiarities support the concept that antithyroid drugs should be the first-line treatment in Alemtuzumab-induced Graves' hyperthyroidism. (frontiersin.org)
- Thy- roidectomy for hyperthyroidism was first performed in 1880, and antithyroid drugs and radioiodine therapy were developed in the early 1940s. (who.int)
Methimazole3
- Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity. (nih.gov)
- The first line of treatment is antithyroid agents , such as methimazole and potassium perchlorate. (healthline.com)
- A number of teratogenic drugs such as Methimazole, a Thiomidazole derivative used as an antithyroid agent, have shown to be involved [ 10 - 13 ]. (hindawi.com)
Carbimazole1
- Carbimazole is a thyroid reducing agent. (mims.com)
Treated with antithyroid drugs1
- It occurs in about 0.2 to 0.3% of cases treated with antithyroid drugs. (wikipedia.org)
Drugs5
- Thioguanine is an anticancer (antineoplastic) agent belonging to the class of drugs called antimetabolites. (encyclopedia.com)
- Retrospective analysis of 18 cases with agranulocytosis induced by antithyroid drugs]. (nih.gov)
- Antithyroid drugs. (nih.gov)
- Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (drugbank.ca)
- From a clinical point of view, Alemtuzumab-induced GD is characterized by a surprisingly high rate of remission, both spontaneous and after antithyroid drugs, as well as by a spontaneous shift to hypothyroidism, which is supposed to result from a change from stimulating to blocking TSH-receptor antibodies. (frontiersin.org)
Potential antithyroid1
- The designed compounds in this study showed a promising activity profile in reducing levels of thyroid hormones and follow up experiments will be needed to confirm the use of the designed compounds as new potential antithyroid agents. (mdpi.com)
Iodine3
- The antithyroid effect of these compounds was ascertained in vitro by studying their complexation with iodine spectrophotometrically. (scielo.org.mx)
- A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. (fpnotebook.com)
- According to Weinstein, "The majority of patients treated with antithyroid medications will relapse and need to move forward with more definitive therapy with either radioactive iodine ablation or surgery. (healthline.com)
Thiourea1
- Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticosteroids or other immunosuppressants, together with withdrawal of the causative agent. (hkmj.org)
Medication3
- A study has shown no difference in outcome for adding thyroxine to antithyroid medication and continuing thyroxine versus placebo after antithyroid medication withdrawal. (wikipedia.org)
- Medically treated Graves disease has a significant risk of relapse (23% within 6 months of discontinuation of antithyroid medication and 42% within 5 years). (medscape.com)
- The recurrence rate of patients with Graves' disease (GD) is estimated to be 50-55% after withdrawal of antithyroid drug therapy , and relapse is frequent in the first year after discontinuing the medication. (bvsalud.org)
Medications3
- In Graves' disease, treatment with antithyroid medications must be given for six months to two years, in order to be effective. (wikipedia.org)
- Side effects of the antithyroid medications include a potentially fatal reduction in the level of white blood cells. (wikipedia.org)
- Particular attention to medications to identify possible causative agent. (oncologynurseadvisor.com)
Relapse1
- Definitive treatment was performed in cases of poor compliance with antithyroid drug (ATD) treatment, thyrotoxicosis relapse, or major adverse effects of ATD treatment. (nih.gov)
Thiouracil2
- One of the mostly used antithyroid agents is 6- n- propyl-2-thiouracil (PTU). (mdpi.com)
- In the current study, the structural activity relationship (SAR) was performed on the thiouracil nucleus of PTU to target these hydrophobic side chains and gain more favorable interactions and, in return, more antithyroid activity. (mdpi.com)
Discontinuation2
- We enrolled patients whose GD was completely treated after initial treatment with antithyroid agents who then developed subclinical thyrotoxicosis after discontinuation of antithyroid agents . (bvsalud.org)
- Abrupt discontinuation of any beta-adrenergic-blocking agent, including nadolol, can result in the development of myocardial ischemia, myocardial infarction, ventricular arrhythmias, or severe hypertension, particularly in patients with preexisting cardiac disease. (pdr.net)
Substances1
- Note: This is not a list of products, but active agents and substances known or purported to cause hair loss as a side effect. (regrowth.com)
Thyrotoxicosis2
- Follow-up examination of these patients frequently reveals laboratory findings consistent with subclinical thyrotoxicosis in the first year after stopping the antithyroid agents . (bvsalud.org)
- We investigated the risk of recurrence of GD among patients with resurfacing subclinical thyrotoxicosis state after remission of initial GD with antithyroid treatments . (bvsalud.org)
Remission1
- A positive TSHR-Ab at the end of antithyroid drug treatment increases the risk of recurrence to 90% (sensitivity 39%, specificity 98%), a negative TSHR-Ab at the end of antithyroid drug treatment is associated with a 78% chance of remaining in remission. (wikipedia.org)
Corticosteroids1
- 7. Hormones and agents affecting hormonal mechanisms: Adrenal corticosteroids. (worldcat.org)
Iodide3
- Thioamides function as antithyroid agents mainly by inhibiting iodide organification and coupling processes, thereby preventing synthesis of thyroid hormones. (medscape.com)
- potassium iodide an expectorant, antithyroid agent, and antifungal. (thefreedictionary.com)
- Potassium Iodide is oral antithyroid agent. (drugbank.ca)
Graves2
- The investigators aimed to compare the results of total thyroidectomy done in 6 months following the appearance of the symptoms of ophthalmopathy and the antithyroid drug therapy in patients with moderate to severe Graves' ophthalmopathy. (clinicaltrials.gov)
- RÉSUMÉ La première description des pathologies thyroïdiennes, telles qu'on les connaît aujourd'hui, a été celle de la maladie de Graves par Caleb Parry en 1786, mais la pathogenèse de l'affection thyroïdienne n'a pas été découverte avant 1882-1886. (who.int)
Antifungal1
- Antifungal agents. (worldcat.org)
Antipsychotic1
- Antipsychotic agents. (worldcat.org)
Derivatives1
- Theophylline Derivatives: Anti-thyroid Agents may increase the serum concentration of Theophylline Derivatives. (pediatriconcall.com)
Pregnancy1
- Although these agents fall under pregnancy category D, they have been used safely in many pregnant patients. (medscape.com)
Adrenal1
- 3. Mitotane (Lysodern) cytotoxic agent that is toxic to adrenal glands for inoperable adrenocoritcal cancer. (studystack.com)
Hormones2
- An antithyroid agent is a hormone antagonist acting upon thyroid hormones. (wikipedia.org)
- Cyanide is an anti-thyroid agent that stops the gland from synthesizing hormones that bond to their receptors. (davidwolfe.com)
Potassium2
- A less common antithyroid agent is potassium perchlorate. (wikipedia.org)
- potassium permanganate a topical antiinfective and oxidizing agent, and an antidote for many poisons. (thefreedictionary.com)
Anti-thyroid agent1
- NeoMercazole is an anti-thyroid agent. (mims.com)
Compounds1
- In vivo, the hormonal as well as histological variations in male Wistar rats demonstrated significant antithyroid potential (p ≤ 0.05) of these compounds. (scielo.org.mx)
Treatment3
- the other group will be followed under antithyroid drug treatment and their TSH levels will be kept between 0.4-1 also. (clinicaltrials.gov)
- Active agent can be incorporated in many dosage forms in such a way to achieve a convenient and efficacious drug delivery system for the treatment of diseases based on the route of administration. (ijpsonline.com)
- For the treatment of hypertension, either alone or in combination with other antihypertensive agents, especially thiazide diuretics. (pdr.net)
Class2
- The oxazolidinones are a new class of antimicrobial agents which have a unique structure and good activity against gram-positive pathogenic bacteria. (hindawi.com)
- Oxazolidinones represent a new class of synthetic antibacterial agents active against multiple-resistant gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant streptococci, and vancomycin-resistant enterococci [ 1 ]. (hindawi.com)
Antineoplastic1
- Melphalan is an anticancer (antineoplastic) agent. (encyclopedia.com)
Antihypertensive agents1
- Antihypertensive agents. (worldcat.org)
Concentrations1
- Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis. (nih.gov)
Chemical1
- Extraction of acidic degradation products of organophosphorus chemical warfare agents. (nist.gov)
Antiprotozoal1
- Antiprotozoal agents. (worldcat.org)
Antiarrhythmic1
- Antiarrhythmic agents. (worldcat.org)
Anticancer1
- Melphalan is a nitrogen mustard derivative and belongs to the group of alkylating anticancer agents. (encyclopedia.com)
Mechanisms1
- Agents have been reported to alter intrathyroidal immunoregulatory mechanisms. (medscape.com)