Antithrombin Proteins: An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.Antithrombin III: A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.Antithrombin III Deficiency: An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.Antithrombins: Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.Heparin: A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.Factor Xa: Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Protein S Deficiency: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)Thrombophilia: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.Venous Thromboembolism: Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.Protein S: The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Protein C Deficiency: An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)Activated Protein C Resistance: A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.Fluorescein: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Polyporaceae: A family of bracket fungi, order POLYPORALES, living in decaying plant matter and timber.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Molecular Weight: The sum of the weight of all the atoms in a molecule.Tuberculin: A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.Plasma Exchange: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.Sarcoma 180Anticoagulants: Agents that prevent clotting.Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.International Normalized Ratio: System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Rickettsia: A genus of gram-negative, aerobic, rod-shaped bacteria often surrounded by a protein microcapsular layer and slime layer. The natural cycle of its organisms generally involves a vertebrate and an invertebrate host. Species of the genus are the etiological agents of human diseases, such as typhus.Acetonitriles: Compounds in which a methyl group is attached to the cyano moiety.Ureaplasma: A genus of gram-negative, nonmotile bacteria which are common parasitic inhabitants of the urogenital tracts of humans, cattle, dogs, and monkeys.Biological Specimen Banks: Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Rehydration Solutions: Fluids restored to the body in order to maintain normal water-electrolyte balance.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Fluid Therapy: Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Dehydration: The condition that results from excessive loss of water from a living organism.Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Glycocalyx: The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.Anoxia: Relatively complete absence of oxygen in one or more tissues.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.

Intracellular accumulation of antithrombin Morioka (C95R), a novel mutation causing type I antithrombin deficiency. (1/31)

Antithrombin (AT) is a major plasma protease inhibitor with three intramolecular disulfide bonds, and its deficiency is associated with increased venous thrombosis. Recently, we found a novel missense mutation named AT Morioka (C95R), which causes the loss of one of the three disulfide bonds. In this study, we prepared Chinese hamster ovary cells stably overexpressing wild type or mutant AT and examined the intracellular fate of the ATs. In pulse-chase experiments, newly synthesized wild type AT was secreted into the medium with a half-life of approximately 1.5 h. In contrast, most of the mutant type AT was not secreted during the chase period of 9 h and, surprisingly, was not degraded in the cells. The kinetics of the secretion suggests that the mutant was secreted about 50 times more slowly into the medium. Most of the mutant AT in the cells had high mannose type oligosaccharides, suggesting that it was retained in the endoplasmic reticulum (ER). In addition, half of the mutant AT existed in a dimeric form with an intermolecular disulfide bond. On immunoelectron microscopy, the mutant AT was found to have accumulated in variously sized structures surrounded by a single membrane in the cytoplasm. Immunogold particles exhibiting calnexin immunoreactivity were detected on the membranes. Ribosomes were attached to some of the small structures that had accumulated the mutant AT. Further, we prepared Chinese hamster ovary cells stably overexpressing another mutant AT in which two cysteine residues at 21 and 95, responsible for disulfide bond formation, were substituted for arginines. In pulse-chase experiments, the mutant AT (C21C,C95R) was secreted faster than that of AT Morioka (C95R) into the medium. These results suggest that AT Morioka remained for a long time in ER without being degraded and accumulated in newly formed membrane structures derived from the ER. The dimerization of AT Morioka (C95R) through Cys-21 seems to be critical for its intracellular accumulation.  (+info)

Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis. (2/31)

A novel variant of antithrombin, the major serpin inhibitor of coagulation proteases, has been identified in a patient with early onset thrombosis and abnormal plasma antithrombin activity. Sequencing of the antithrombin genes of the patient revealed that one of the two alleles was abnormal due to an in-frame deletion of the codon for the P1 arginine residue. The abnormal antithrombin was separated from the normal inhibitor by complexing the latter with thrombin followed by heparin-agarose affinity chromatography. The purified variant, antithrombin London, was completely inactive as a thrombin or factor Xa inhibitor even after heparin activation. Surprisingly, the variant bound heparin with a K(D) reflecting an approximately 10-fold greater affinity than the normal inhibitor. Stopped-flow kinetic analysis showed that this was almost entirely due to a more favorable conformational activation of the variant than the normal inhibitor, as reflected by a decreased rate constant for reversal of the activation. Consistent with its higher than normal heparin affinity, the inactive antithrombin variant was a potent competitive antagonist of the heparin-catalyzed reaction of normal antithrombin with thrombin but did not affect the uncatalyzed reaction. These results suggest that deletion of the antithrombin P1 residue partially activates the serpin by inducing strain in the reactive center loop, which destabilizes the native loop-buried state and favors the activated loop-exposed state with high heparin affinity. The unusually severe thrombosis associated with the heterozygous mutation may be explained by the ability of antithrombin London to bind endogenous heparan sulfate or heparin molecules with high affinity and to thereby block activation of the normal inhibitor.  (+info)

P1 variant antithrombins Glasgow (393 Arg to His) and Pescara (393 Arg to Pro) have increased heparin affinity and are resistant to catalytic cleavage by elastase. Implications for the heparin activation mechanism. (3/31)

The heparin affinity of normal and two P1 variants of antithrombin-III (AT) was studied by gradient elution with NaCl in Tris buffer on heparin-Sepharose. At pH 7.4 normal AT eluted at [Na+] 0.78 mol/l and the variants both showed increased affinity with AT Pescara eluting at [Na+] 0.86 mol/l and AT Glasgow at [Na+] 0.92 mol/l. We have earlier proposed a model for heparin activation in which the native state of AT maintains a salt bridge involving the P1 Arg-393 residue. Binding of heparin induces a higher heparin affinity conformation in which the salt bridge is disrupted to reveal the reactive centre for inhibition of thrombin. The Glasgow and Pescara variants, lacking a reactive centre P1 basic residue, would be unable to form this salt bridge, and we suggested that the high affinity conformation which they adopt as their native state would resemble the heparin induced conformation. To examine this model, we measured the heparin induced fluorescence of two P1 variants and tested the susceptibility of their reactive loops to catalytic cleavage. Both variants had fluorescence spectra indistinguishable from normal AT. In the absence of heparin, neither variant was more susceptible than normal to catalytic cleavage by human neutrophil elastase. These findings suggest that the conformation of these P1 variants is different to that of fully heparinized normal AT.  (+info)

Replacement of Phe274 with conserved residue Tyr274 for reactive center loop expulsion in antithrombin. (4/31)

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Use of dabigatran etexilate to reduce breast cancer progression. (5/31)

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Endothelial differentiation of adipose-derived stem cells from elderly patients with cardiovascular disease. (6/31)

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Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives. (7/31)

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Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. (8/31)

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PRODUCT MONOGRAPH Pr PRADAXA Dabigatran Etexilate Capsules Capsules 75 mg, 110 mg and 150 mg Dabigatran Etexilate, (as Dabigatran Etexilate Mesilate) Anticoagulant Boehringer Ingelheim Canada Ltd. 5180
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Background: Dabigatran etexilate is one of the few direct thrombin inhibitors with anti-coagulant activities and the following distinctive features: taken orally, no need to closely monitor for complications, and no need for regular dose adjustments. Relying on the above mentioned valuable advantages, dabigatran etexilate can be considered as a premier choice ...
Comparisons between dabigatran trough plasma levels as predicted by simulations to those observed in the study are performed to validate the dosing algorithm for Dabigatran Etexilate (DE).. (As the trial was stopped prematurely, EOT may not be 12 weeks after randomisation for most of the patients). Despite the primary endpoint only being assessed in patients who received dabigatran etexilate, Warfarin was included as a comparator treatment in this study in order to facilitate informal comparisons of outcome events, and to look for efficacy signals in this previously unexplored population. ...
Comparisons between dabigatran trough plasma levels as predicted by simulations to those observed in the study are performed to validate the dosing algorithm for Dabigatran Etexilate (DE).. (As the trial was stopped prematurely, EOT may not be 12 weeks after randomisation for most of the patients). Despite the primary endpoint only being assessed in patients who received dabigatran etexilate, Warfarin was included as a comparator treatment in this study in order to facilitate informal comparisons of outcome events, and to look for efficacy signals in this previously unexplored population. ...
This study investigated the pharmacikinetics and pharmacodynamics of dabigatran etexilate after switching from enoxaparin sodium to dabigatran etexilate as
Economic evaluation of dabigatran etexilate for the preventionof venous thromboembolism in patients aged over 75 years or with moderate renal impairment undergoing total knee or hip replacement
[128 Pages Report] Check for Discount on Global Dabigatran Etexilate Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Dabigatran Etexilate Revenue,...
Dabigatran etexilate, a prodrug of dabigatran, which reversibly inhibits the active site of thrombin, has an oral bioavailability of ≈6%.39 After oral administration, dabigatran etexilate is rapidly and completely converted to dabigatran by esterases. Plasma levels of dabigatran peak ≈2 hours after drug administration. Dabigatran has a half-life of 14 to 17 hours, which permits once- or twice-daily administration, and ≈80% of the drug is excreted unchanged by the kidneys. Dabigatran etexilate is a substrate of the P-glycoprotein (P-gp) transporter. This efflux transporter is highly expressed in the intestine and kidneys, and coadministration of potent P-gp inhibitors, such as quinidine, can increase plasma levels of dabigatran by reducing its clearance.37 Consequently, quinidine is contraindicated in patients taking dabigatran etexilate. Coadministration of dabigatran etexilate and amiodarone, a weak P-gp inhibitor, increases dabigatran levels by ≈50% without significantly affecting ...
7 matching references were found. Nakamura; Morioka; Hayaishi; Ishiguro; Sasanuma, 3rd International Conference on Vacuum Ultraviolet Radiation Physics - Paper 1pA1-6, Tokyo, 1971, 0. [all data] Sasanuma, M.; Morioka, Y.; Ishiguro, E.; Nakamura, M., Rydberg series in the NO molecule near 600 A, J. Chem. Phys., 1974, 60, 327. [all data] Sasanuma, M.; Ishiguro, E.; Hayaisha, T.; Masuko, H.; Morioka, Y.; Nakajima, T.; Nakamura, M., Photoionisation of SF6 in the XUV region, J. Phys. B:, 1979, 12, 4057. [all data] Hayaishi, T.; Iwata, S.; Sasanuma, M.; Ishiguro, E.; Morioka, Y.; Iida, Y.; Nakamura, M., Photoionisation mass spectrometric study of acetylene in the VUV region, J. Phys. B:, 1982, 15, 79. [all data] Nakamura, M.; Sasanuma, M.; Sato, S.; Watanabe, M.; Yamashita, H.; Iguchi, Y.; Ejiri, A.; Nakai, S.; Yamaguchi, S.; Sagawa, T.; Nakai, Y.; Oshio, T., Absorption structure near the K edge of the nitrogen molecule, Phys. Rev., 1969, 178, 80. [all data] Morioka, Y.; Nakamura, M.; Ishiguro, E.; ...
DIRECT THROMBIN INHIBITORS : USES: Direct thrombin inhibitors (DTIs) are used as anticoagulants. Argatroban, bivalirudin, desirudin, and lepirudin are used parenterally and are indicated for adjuvant anticoagulation for percutaneous cardiac interventions or as a substitution for heparin/low-molecular-weight heparins in cases of heparin-induced thrombocytopenia. Dabigatran etexilate is an oral medication approved for treatment of venous thromboembolism and stroke prophylaxis in atrial fibrillation. PHARMACOLOGY: These agents directly inhibit thrombin, leading to inhibition of clot formation and stabilization. TOXICOLOGY: The toxic effects are extensions of the pharmacologic effects and primarily include bleeding complications. EPIDEMIOLOGY: Outpatient overdose has not yet been reported. Inpatient medication errors may occur in 1% to 2% of patients receiving DTIs. The incidence of overdose is likely to increase as new DTIs are approved for in-hospital parenteral use and oral anticoagulation ...
This study investigated the safety and pharmacodynamics of two doses of dabigatran etexilate compared with heparin in patients undergoing elective percutaneous
Study information from Be Involved at CepEsperu Baptist Medical Center for: Study of the Safety and Efficacy of oral Dabigatran Etexilate for the prevention of recurring Venous Thromboembolism
...RIDGEFIELD Conn. July 11 2007 /PRNewswire/ -- Phase 3 resultsfrom ...Results of the RE-NOVATE trial showed that both oral doses(220mg; 150...Also presented at ISTH was a pooled analysis of major VTE andVTE-rela...,Phase,3,Results,for,Dabigatran,Etexilate,,an,Investigational,Oral,Anticoagulant,,Presented,Today,at,the,XXIst,Congress,of,the,International,Society,on,Thrombosis,and,Haemostasis,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
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Citations for individual image records are available for this collection. Browse through images in this collection and click on the "Show Citation" box: Italy, Pescara, Civil Registration (State Archive), 1865-1929 When you copy information from a record, you should list where you found the information. This will help you or others to find the record again. It is also good to keep track of records where you did not find information, including the names of the people you looked for in the records. A suggested format for keeping track of records that you have searched is found in the wiki article Help:How to Cite FamilySearch Collections. ...
Complete coverage of the Pescara Calcio v AS Varese 1910 match including videos, highlights, interviews, match reports and debates.
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package Some::Class; use Sentinel; sub foo :lvalue { my $self = shift; sentinel get =, sub { return $self-,get_foo }, set =, sub { $self-,set_foo( $_[0] ) }; } sub bar :lvalue { my $self = shift; sentinel value =, $self-,get_bar, set =, sub { $self-,set_bar( $_[0] ) }; } sub splot :lvalue { sentinel obj =, shift, get =, \&get_splot, set =, \&set_splot; } sub wibble :lvalue { sentinel obj =, shift, get =, get_wibble, set =, set_wibble ...
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Andrea LEDDA 1, 2, Gianni BELCARO 1, 2 ✉, Beatrice FERAGALLI 1, 2, Morio HOSOI 1, 2, Marisa CACCHIO 1, 2, Roberta LUZZI 1, 2, Mark DUGALL 1, 2, Roberto COTELLESE 1, 2. 1 Department of Medical and Oral Sciences and Biotechnology, Irvine3 Labs, University of Chieti-Pescara, Pescara, Italy; 2 International Agency For The Evaluation of Pharma-Standard Supplements (IA-PSS), Pescara, Italy. ...
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Principal Investigator:MORIOKA Yukiko,鈴木 育子,千葉 ヒロ子, Project Period (FY):1995 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Nursing
Richards, Stephen ; Gibbs, Richard A. ; Gerardo, Nicole M. ; Moran, Nancy ; Nakabachi, Atsushi ; Stern, David ; Tagu, Denis ; Wilson, Alex C.C. ; Muzny, Donna ; Kovar, Christie ; Cree, Andy ; Chacko, Joseph ; Chandrabose, Mimi N. ; Dao, Marvin Diep ; Dinh, Huyen H. ; Gabisi, Ramatu Ayiesha ; Hines, Sandra ; Hume, Jennifer ; Jhangian, Shalini N. ; Joshi, Vandita ; Lewis, Lora R. ; Liu, Yih Shin ; Lopez, John ; Morgan, Margaret B. ; Nguyen, Ngoc Bich ; Okwuonu, Geoffrey O. ; Ruiz, San Juana ; Santibanez, Jireh ; Wright, Rita A. ; Fowler, Gerald R. ; Hitchens, Matthew E. ; Lozado, Ryan J. ; Moen, Charles ; Steffen, David ; Warren, James T. ; Zhang, Jingkun ; Nazareth, Lynne V. ; Chavez, Dean ; Davis, Clay ; Lee, Sandra L. ; Patel, Bella Mayurkumar ; Pu, Ling Ling ; Bell, Stephanie N. ; Johnson, Angela Jolivet ; Vattathil, Selina ; Williams, Rex L. ; Shigenobu, Shuji ; Dang, Phat M. ; Morioka, Mizue ; Fukatsu, Takema ; Kudo, Toshiaki ; Miyagishima, Shin Ya ; Jiang, Huaiyang ; Worley, Kim C. ; ...
Avec K-M9+, non confirmé, mais probablement T1-M70+ : 14 % (3/23) de Russes de loblast de Yaroslavl[39], 12,5 % (3/24) dItaliens à Matera[40], 10,3 % (3/29) dItaliens à Avezzano[40], 10 % (3/30) de Tyroliens du Val di Non[40], 10 % (2/20) dItaliens de Pescara[40], 8,7 % (4/46) d[Italians de Bénévent[40], 8,3 % [4/48) dItaliens de Cilento[40], 8,3 % (7/84) dItaliens de lOuest Campanie[41], 7,8 % (4/51) dItaliens du Sud Latium[41], 7,4 % (2/27) dItaliens de Paola en Calabre[40], 7,3 % (11/150) dItaliens en Centre-Sud Italie[42], 7,1 % (8/113) de Serbes en Serbie[43], 7 % (6/86) de Sardes à Tempio[44], 4,7 % (2/42) dAroumains en Roumanie[45], 3,7 % (3/82) dItaliens à Biella[46], 3,7 % (1/27) dAndalous de la province de Cordoue[28], 3,3 % (2/60) de Léonais de la province de León,[28], 3,2 % (1/31) dItaliens à Postua[46], 3,2 % (1/31) dItaliens à Cavaglià[46], 3,1 % (3/97) de Calabrais à Reggio de Calabre,,[33] . 2,8 % (1/36) de Russes dans une partie de la Russie[47], 2,8 ...
TY - JOUR. T1 - Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy. AU - Avecilla, Scott T.. AU - Ferrell, Chris. AU - Chandler, Wayne L.. AU - Reyes Gil, Morayma. PY - 2012/4. Y1 - 2012/4. N2 - New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for routine therapeutic monitoring, there are clinical scenarios in which monitoring can help guide clinical management. We report herein the application of a recently described plasma-diluted thrombin time (DTI assay) used to monitor intravenous DTI as a useful and easily implemented method to monitor oral DTIs. Copyright. AB - New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the ...
Evidence-based recommendations on dabigatran etexilate (Pradaxa) for preventing stroke and systemic embolism in atrial fibrillation (AF)
RIDGEFIELD, Conn., Nov. 4, 2012 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. presented study results from a new retrospective sub-analysis of the RE-LY® trial that indicated patients with non-valvular atrial fibrillation (NVAF) who also have diabetes experienced similar safety and efficacy with Pradaxa® (dabigatran etexilate mesylate) 150mg or dabigatran 110mg* relative to warfarin, in comparison to patients with NVAF who do not have diabetes. This data was presented today during the American Heart Associations Scientific Sessions 2012.. Diabetes affects 25.8 million Americans. It is one of the most common conditions associated with atrial fibrillation (AFib), and patients with both conditions have up to double the risk of experiencing a stroke compared to those with only AFib.. "These results are encouraging, as they indicate PRADAXA 150mg twice daily is effective in this higher risk NVAF patient population, a group in need of effective treatments," said Paul Reilly, PhD, ...
The RE-DUAL PCI™ trial explored anticoagulation with Pradaxa® (dabigatran etexilate) dual therapy without aspirin in non-valvular atrial fibrillation (AF) patients following percutaneous coronary intervention (PCI) and stent placement: results showed significantly lower rates of major or clinically relevant non-major bleeding events for dual therapy with Pradaxa® when compared to triple therapy with warfarin.1,2 The risk for the primary safety endpoint was 48% lower for Pradaxa® 110 mg dual therapy and 28% lower for Pradaxa® 150 mg dual therapy (relative difference), with similar rates of overall thromboembolic events. Both Pradaxa® doses have been approved by regulatory authorities around the world for stroke prevention in AF. The results were presented today as a late-breaker at the ESC Congress 20171 and have been simultaneously published in the New England Journal of Medicine. 2 This Smart News Release features multimedia. View the full release here: http://www.businesswire.com/new
Boehringer Ingelheim Pharmaceuticals, Inc. Release: Pradaxa(R) (dabigatran etexilate mesylate) U.S. Label Now Affirms Superior Reduction in Ischemic and Hemorrhagic Stroke Versus Warfarin in Patients with Non-Valvular Atrial Fibrillation - read this article along with other careers information, tips and advice on BioSpace
[03-29-2011] The U.S. Food and Drug Administration (FDA) is alerting the public to important storage and handling requirements for Pradaxa (dabigatran etexilate mesylate) capsules.
View the latest weather forecasts, maps, news and alerts on Yahoo Weather. Find local weather forecasts for Pescara, Italy throughout the world
The Best Practice Advocacy Centre delivers educational and continuing professional development programmes to medical practitioners and other health professional groups throughout New Zealand.
University of Washington Press in 2008 published a biography of Blakemore by art historian Michiyo Morioka titled An American Artist In Tokyo. "Her experience with Japan encompassed the entire period from pre-World War II militarism to postwar modernization," Morioka wrote.. "Arriving in Tokyo in 1935 to teach art and English, she became fascinated with Japanese life and chronicled her experiences both in art and writing. She spent most of the war years in Honolulu, where she designed propaganda leaflets that were dropped by the millions on the Japanese islands. In 1954, she married American attorney Thomas Blakemore and achieved prominence as an artist and gallery owner in Tokyo.". In 1990 the Blakemores established the Blakemore Foundation, with the mission "to encourage Americans to develop greater fluency in Asian languages and to increase understanding of Asian art in the United States." In 1996, they donated more than 300 objects to the Henry, including Japanese prints, textiles, stencils ...
A Women with Masters Degree, A Wife to my Beloved husband, A Mother of Two Amazing Sons (so far and counting), An Employee for 8.30-5.30 Office Hour Company, A part time Online & Offline Seller.. live in Seri Kembangan, Selangor.. Hey what else other than feel free to visit this blog and contact me if you want to purchase these eye-catchers items..So all I need is to sit back and waiting for my good customer *wink*wink - ...
Abstract. Inhibition of two key serine proteases in the coagulation cascade, thrombin (IIa) and factor Xa, are currently being exploited for direct, oral antit
A formulary or similar such committee is a multidisciplinary committee composed of regular members that (i) operates under standard procedures, (ii) engages in a deliberative process to review and analyze clinical, economic, healthcare outcomes and other data, including scientific studies and technology assessments, and (iii) selects drugs for access by a population of identified patients, and (iv) is charged with setting limits on such access to control drug utilization and costs, and manage quality for its patient population.. By clicking on the button below you are certifying that you are formulary decision maker, serve on a formulary or similar such committee, or are an organizational representative in a managed care or similar organization whose role is to serve routinely and/or formally as a conduit through which health economic or other such pertinent information is provided to a formulary committee or similar committee and decision makers to enable drug access decisions per the ...
Boehringer Ingelheim announced that the prescribing information for Pradaxa (dabigatran etexilate mesylate) capsules was updated to include a contraindication related to use in patients with mechanical prosthetic heart valve replacement.
I had planned my story carefully. I would give my birth name, mention the shogunate as an enemy, and looked scared. I even practiced my voice wavering in all the right places. I had stashed my armor in a snow-covered bush and taken to the sky. Morioka was beneath me in moments.. Id hidden in shadow, watching Takiko brush my horse. I moved closer when she spoke to a young man obviously in love with her. The wind carried their words and when he left I stepped into the open.. She was looking at the man, her face pained.. Did she love him too?. I watched him shuffle away, angry that he would just leave. Her injury was worse than she let on. He should have pushed more.. She saw me and our eyes met. She glanced behind her in indecision and then made her way forward. The girl whod stolen my horse and sword, left me to die, and fought against the regime Id built my whole life around, moved as someone impossibly fragile.. Her gait was slow and she leaned heavily on her good side. The limp worsened as ...
Nakamura A, Fujita M, Ono H, Hongo Y, Kanbara T, Ogawa K, Morioka Y, Nishiyori A, Shibasaki M, Mori T, Suzuki T, Sakaguchi G, Kato A, Hasegawa ...
Huie JR, Morioka K, Haefeli J, Ferguson AR Spinal cord injury (SCI) is a devastating syndrome that produces dysfunction in motor and sensory s …
Hiroki Watanabe, Hiroki Shiomi, Kenji Nakatsuma, Takeshi Morimoto, Tomohiko Taniguchi, Yutaka Furukawa, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura, the CREDO‐Kyoto AMI investigators, Takeshi Kimura, Ryuzo Sakata, Akira Marui, Mitsuo Matsuda, Hirokazu Mitsuoka, Masahiko Onoe, Yoshihisa Nakagawa, Kazuo Yamanaka, Hisayoshi Fujiwara, Yoshiki Takatsu, Nobuhisa Ohno, Ryuji Nohara, Tomoyuki Murakami, Teruki Takeda, Masakiyo Nobuyoshi, Masashi Iwabuchi, Michiya Hanyu, Ryozo Tatami, Tsutomu Matsushita, Manabu Shirotani, Noboru Nishiwaki, Toru Kita, Yutaka Furukawa, Yukikatsu Okada, Hiroshi Kato, Hiroshi Eizawa, Katsuhisa Is, Masaru Tanaka, Shogo Nakayama, Jong‐Dae Lee, Akira Nakano, Takaaki Koshiji, Koichi Morioka, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Masaaki Takahashi, Junichiro Nishizawa, Minoru Horie, Hiroyuki Takashima, Takashi Tamura, Masaki Aota, Mamoru Takahashi, Takafumi Tabata, Chuwa Tei, Shuichi Hamasaki, Yutaka Imoto, Hiroyuki Yamamoto, Hirofumi Kambara, Osamu Doi, ...
TY - JOUR. T1 - The unfolded protein response in skeletal development and homeostasis. AU - Horiuchi, Keisuke. AU - Tohmonda, Takahide. AU - Morioka, Hideo. PY - 2016/3/22. Y1 - 2016/3/22. N2 - Osteoblasts and chondrocytes produce a large number of extracellular matrix proteins to generate and maintain the skeletal system. To cope with their functions as secretory cells, these cells must acquire a considerable capacity for protein synthesis and also the machinery for the quality-control and transport of newly synthesized secreted proteins. The unfolded protein response (UPR) plays a crucial role during the differentiation of these cells to achieve this goal. Unexpectedly, however, studies in the past several years have revealed that the UPR has more extensive functions in skeletal development than was initially assumed, and the UPR critically orchestrates many facets of skeletal development and homeostasis. This review focuses on recent findings on the functions of the UPR in the differentiation ...
In bionet.women-in-bio Warren Gallin ,wgallin at gpu.srv.ualberta.ca, wrote: : In Article ,6bislu$sk1$1 at Mars.mcs.net,, finch at MCS.COM (Deirdre : Sholto-Douglas) wrote: : ,One of my all-time favourite test questions is Is the pH of DNA acidic : ,or basic? i : Actually, its QUESTIONS like that that make me cringe. pH refers to the : proton concentration of a [usually] aqueous solution. So the pH of a : solution of DNA can by anywhere, depending on how it was made. The students : who really know waht is going on would have a real problem deciding what to : answer for this one. In this level of Bio, the first term, things which have the word *acid* in the name are considered to be acidic. If I had asked Is the pH of sulphuric acid acidic or basic? would you honestly wibble about and say It depends? Our initial course is *not* a weed-out, its a basic overview of biological terms (Such as theory, fact and method), a chance to introduce them to safe lab technique and a swift journey ...
Andrea Salvatore Cocco (born 8 April 1986) is an Italian footballer who plays as a striker for Serie B side Pescara. Cocco made his Serie A debut on 21 December 2005 for Cagliari in a 1-0 defeat away to Parma F.C.. On 31 January 2007 he left for Venezia. and on 31 August 2007 for Pistoiese. Cocco was sold to Rovigo in a co-ownership deal in August 2008. In June 2009 Cagliari bought Cocco and Andrea Peana (from Triestina) back, but sold them to Alghero immediately in co-ownership deals (later Simone Aresti also joined), where Cocco also met ex-team-mate Alessio Cossu, Nicola Lai and Enrico Cotza (in January). In June 2010, few week before the bankrupt of Alghero, Cagliari bought back Cocco and Aresti for €500. Few days after Cagliari signed Gabriele Perico and Simon Laner from AlbinoLeffe in temporary deals for €750,000 (€375,000 each), Cocco was sold to AlbinoLeffe in co-ownership deal for €50,000 in a 3-year deal, making Cagliari only paid AlbinoLeffe €700,000 in cash. In June 2011 ...
Italy go for the Under-21 European Championship play-offs against Sweden with Ciro Immobile, Lorenzo Insigne and Giuseppe De Luca in attack.. The Azzurrini topped their group and tonight welcome their Swedish counterparts to the Stadio Adriatico in Pescara.. The first leg of the play-off kicks off at 20.00 BST and has several Serie A regulars in the starting XI.. These include Milan full-back Mattia De Sciglio, Roma midfielder Alessandro Florenzi and the attacking trio of Genoas Immobile, Napolis Insigne and Atalantas De Luca.. Fabio Borini was expected to start, but the Liverpool striker fractured his foot in training this week.. Italy U21: Bardi; De Sciglio, Frascatore, Capuano; Marrone, Caldirola, Saponara, Florenzi; Immobile, Insigne, De Luca. Sweden U21: Johnsson; M Johansson, Jansson, Pettersson, Demir, Hamad, Hiljemark, J Johansson, Claesson, Ishak, Armenteros. ...
Proteins perform their function for adopting a particular 3D structure, referred as native structure, and failure to fold into the native structure has profound deleterious effects, frequently causing diseases
click here for more for getting good nutrition is to calculate how many calories you are taking in every day. Get a pen and paper or use your computer to jot down all of the calorie information for each food item you plan to eat for the day. This will give you a sense of just how much food you are really eating, and it will allow you to set goals to better balance out your meals ...
A major component of this work will be partnership between patients & parents and the care team, especially those of us who will be working together closely on quality improvement teams. I had a somewhat failed first try at partnership with our care team, and Im working to learn what successful partnerships have looked like with other learning networks - how patients and parents are working with care team and in what capacity, whats working and whats not from the perspective of both sides. For example, I know a parent partner on one of the IBD teams who works very closely with the care team on their QI efforts as part of the network, runs the patient and family advisory council, but doesnt get paid. She also serves as the go-between for the families and the care team. I had always envisioned more of a partnership, like one big team, rather than two teams (clinicans and families) working together seamlessly. Im trying to learn what the parents view as valuable and what they wish was ...
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. The results for both activity and antigen tests are given as percentages. Different labs use slightly different normal ranges, but in general, 80% to 120% is considered normal for adults. Newborns usually have about half as much antithrombin as adults. Thrombin levels in infants rise to adult levels by about 6 months of age.. People with genetically inherited antithrombin deficiency typically have test results between 40% and 60%.. In both type 1 and type 2 AT deficiency, the antithrombin activity test shows a low result because you dont have as much working antithrombin as you should have. When the AT activity test shows that levels are low, the antithrombin antigen test can then be used to find out whether the deficiency is type 1 or type 2.. If the follow-up ...
AIMS: To summarize and analyse the published literature on the efficacy and safety of dabigatran for anticoagulation during atrial fibrillation (AF) ablation.. METHODS AND RESULTS: A comprehensive search of the literature in the English language was conducted and 10 studies were identified which compared dabigatran therapy with warfarin. Data were extracted and meta-analysed using appropriate methodology. There was significant clinical heterogeneity among studies concerning study designs and methodologies. Most studies consisted of retrospective single-centre observational studies. A total of 3648 patients were included of whom 2241 were receiving warfarin and 1407 dabigatran. Only 12 thrombo-embolic events were reported, 3 during warfarin and 9 during dabigatran therapy [odds ratio (OR) 2.38, 95% confidence interval (CI) 0.82-6.85, P = n.s.). The pooled rate of major bleeding events was similar for warfarin and for dabigatran (OR 1.05, 95% CI 0.62-1.80; P = n.s.). Rates of minor bleeding events ...
A method for the differential determination of plasma antithrombins, antithrombin III and alpha2 macroglobulin, is described. The method is based on the selective inactivation of plasma alpha2 macroglobulin by treatment with 0-1 M methylamine for 10 minutes at 37 degrees C and on the observation that antithrombin III and alpha2 macroglobulin inhibited in defibrinated plasma low concentrations of thrombin without mutual interference and according to pseudo-first order reaction. In healthy subjects antithrombin III was shown to account for about 70% of the total antithrombin activity. But in patients with liver cirrhosis, where low levels of total antithrombin activity were observed, the relative contribution of antithrombin III was found to be noticeably lower.. ...
Atrial fibrillation (AF), the most common clinically significant cardiac arrhythmia, has an estimated diagnosed prevalence of about 1.4% in the UK and is rising.1 2 Patients with AF have a fivefold increased risk of stroke compared with those in sinus rhythm.3 Stroke events result in substantial management and follow-up care, and the incurred costs tend to be higher in stroke patients with AF than those without.3 4 Additionally, AF is associated with an increased risk of non-cranial systemic embolism (SE).5 Despite the substantial clinical risks and economic costs, many patients with AF receive inadequate stroke prevention treatment resulting in a rising burden of stroke in patients with AF in the UK.2 3. One of the principal aims of AF treatment is to avoid thromboembolic events by instituting antithrombotic therapy.3 Vitamin K antagonists such as warfarin may prevent up to 64% of strokes in patients with non-valvular AF.6 However, warfarin treatment is complex; it has many important ...
Background Two phase 3 trials compared 28-35 days of treatment with oral dabigatran 220 mg or 150 mg (RE-NOVATE) or 220 mg (RE-NOVATE II) once daily with subcutaneous enoxaparin 40 mg once daily for...
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. The results for both activity and antigen tests are given as percentages. Different labs use slightly different normal ranges, but in general, 80% to 120% is considered normal for adults. Newborns usually have about half as much antithrombin as adults. Thrombin levels in infants rise to adult levels by about 6 months of age. People with genetically inherited antithrombin deficiency typically have test results between 40% and 60%. In both type 1 and type 2 AT deficiency, the antithrombin activity test shows a low result because you dont have as much working antithrombin as you should have. When the AT activity test shows that levels are low, the antithrombin antigen test can then be used to find out whether the deficiency is type 1 or type 2. If the follow-up ...
Conformational diseases are a newly recognized group of heterogeneous disorders resulting from the conformational instability of individual proteins. Such instability allows the formation of intermolecular linkages between b-sheets, to give protein aggregation and inclusion body formation. The serpin family of serine protease inhibitors provides the best-studied examples of the structural changes involved. Notably, mutations of a-1-antitrypsin result in its intracellular polymerization and accumulation in the liver leading eventually to cirrhosis. Here we consider how other conformational changes in another serpin, antithrombin, can cause its inactivation with consequent thrombosis. Thirteen different missense mutations in antithrombin are associated with either oligomer formation or with conversion of the active molecule into an inactive latent form. Each of these variant antithrombins is associated with an increased risk of thrombosis that typically occurs in an unexpectedly severe and sudden ...
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... is a protein in the blood that helps regulate blood clot formation. Antithrombin testing is used to investigate the cause of recurrent blood clot formation (such as DVT) and to identify an antithrombin deficiency.
following a full submission:. idarucizumab (Praxbind®) is accepted for use within NHS Scotland.. Indication under review: idarucizumab is a specific reversal agent for dabigatran and is indicated in adult patients treated with dabigatran etexilate when rapid reversal of its anticoagulant effects is required for emergency surgery/urgent procedures or in life-threatening or uncontrolled bleeding.. In a phase III, non-randomised, case series study, treatment with idarucizumab reversed the effect of dabigatran, with a median maximum percentage reversal of 100%.. ...
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases until it binds to the heparan side chains that line the microvasculature. The binding specifically occurs to a core pentasaccharide present both in the heparans and in their therapeutic derivative heparin. The accompanying conformational change of antithrombin is revealed in a 2.9-A structure of a dimer of latent and active antithrombins, each in complex with the high-affinity pentasaccharide. Inhibitory activation results from a shift in the main sheet of the molecule from a partially six-stranded to a five-stranded form, with extrusion of the reactive center loop to give a more exposed orientation. There is a tilting and elongation of helix D with the formation of a 2-turn helix P between the C and D helices. Concomitant conformational changes at the heparin binding site explain both the initial tight binding of antithrombin to the heparans and the subsequent release of the antithrombin-protease ...
Takiko Okuda (奧田 多喜子 Okuda Takiko) is the Priestess of Genbu and the heroine of Fushigi Yûgi Genbu Kaiden. The daughter of Einosuke Okuda, the Japanese translator of the original scripture for "The Universe of the Four Gods", Takiko is a serious young girl skilled with the naginata. She demonstrates a strong will and good heart, but shows insecurity with her own abilities and tends to be impulsive. Takiko is sincere, honest, and possesses a strong sense of justice.. When Takikos mother fell ill with tuberculosis, her family moved from Tokyo to Morioka. Takiko spent most of her days taking care of her mother and resented her fathers obsession with The Universe of Four Gods. When her mother dies from her illness, Takikos frustrations with her life, including her unrequited love of Takao Ōsugi and her fathers apparent disappointment with her being born a girl, culminate in an attempt to destroy The Universe of Four Gods to spite her father. Spirited into the book, Takiko is revealed ...
White Paper on the Brandman ideal: Instructional Design for Engaged Adult Learning John Morioka rushes into the building, arriving just in time for the beginning of the class at 5:30 p.m. He listens to
The plasma antithrombin stages, determined as anti-FXa action, experienced a typical distribution in the GAIT study, with a medium worth of 109.05% of the
An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance. . ...
Abruzzi: Abruzzi, regione, central Italy, fronting the Adriatic Sea and comprising the provincie of LAquila, Chieti, Pescara, and Teramo. Most of the region is mountainous or hilly,
Background Preclinical in vivo research using small pets are considered essential in translational cancer research and scientific implementation of novel treatments. purpose, research completed with different tumor histotypes had been considered inside our evaluation including breast, digestive tract, lung, fibrosarcoma, pancreas, mind and melanoma and throat cancers. For all your tumors, buy Dabigatran etexilate mesylate the / proportion was assumed to become 10 Gy, as adopted for neoplastic cells generally. Results Our outcomes support the hypothesis the fact that occurrence buy Dabigatran etexilate mesylate price of abscopal results in preclinical versions boosts with BED. Specifically, the likelihood of uncovering abscopal results is certainly 50% whenever a BED of 60 Gy is certainly generated. Bottom line Our research provides proof that SABR remedies connected with high Bedrooms could be regarded an effective technique in triggering the abscopal impact, losing light in the guaranteeing buy ...
One of the downsides of Dabigatran are lack of a specific inhibitor. This means that if Dabigatran causes bleeding it cannot be directly reversed. A pooled analysis comparing outcomes of patients who were treated with dabigatran and bled to those of patients treated with warfarin was published in Circulation in 2013. Although patients treated with dabigatran tended to be older and to be treated with more anti-platelet agents, they trended to have better outcomes. There are ways, however, to deal with a patient bleeding from Dabigatran. These include time, plasma complex concentrates and tranexamic acid. Neutralizing antibodies are also in development. Read about reversal of direct thrombin inhibitors to learn more.. Surgery can be performed in patient who have received Dabigatran, but time should pass. After dabigatran you should wait 24-72 hours, depending on bleeding risk (low, moderate and high risk). Urgent surgery should never be delayed, even without preparation.. If tPA is needed (such as ...
How can this seemingly disparate evidence be integrated with what was known before? Older data, upon which the guidelines were based, had established that thrombophilia testing was predictive of the relative risk for initial VTE. The situation is completely different for patients who have already had a spontaneous VTE. Why? It has long been known that patients with spontaneous VTE are hypercoagulable, (untreated recurrence rates of 2% to 5% per year) no matter the result of thrombophilia testing. In part this is because comprehensive laboratory testing of clinically thrombophilic patients will yield negative results---no "laboratory lesion"--- in about 30%-40% of cases. The thinking is that those patients have a thrombophilic state that hasnt been discovered yet. To keep it in perspective, remember that the concept of hereditary thrombophilia has been around since the discovery, in 1963, of antithrombin deficiency (Egeberg O: Inherited antithrombin deficiency causing thrombophilia. Thrombosis ...
Clinical Overview of the NOACs Prophylaxis of stroke and systemic embolism in nonvalvular AF Dabigatran etexilate prodrug rapidly absorbed after oral administration and converted to dabigatran direct thrombin inhibitor Rivaroxaban direct factor Xa inhibitor
1. Connolly SJ, Ezekowitz MD, Yusuf S. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-1151 2. Patel MR, Mahaffey KW, Garg J. et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883-891 3. Granger CB, Alexander JH, McMurray JJ. et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981-992 4. Giugliano RP, Ruff CT, Braunwald E. et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369:2093-2104 5. Boehringer Ingelheim Pharmaceuticals I. HIGHLIGHTS OF PRESCRIBING INFORMATION. PRADAXA® (dabigatran etexilate mesylate) capsules, for oral use. Accessed 4 Mar 2019. https://docs.boehringer-ingelheim.com/Prescribing 6. Janssen Pharmaceutical Companies. HIGHLIGHTS OF PRESCRIBING INFORMATION. XARELTO (rivaroxaban) tablets, for oral use. Accessed 4 Mar 2019. ...
Abstract. We have investigated the basis of antithrombin deficiency in an asymptomatic individual (and family) with borderline levels (≈70% antigen and activit
Millions of people regularly take anticoagulant or antiplatelet medications (sometimes called "blood thinners") to help prevent heart attack and stroke, and to manage a variety of medical conditions including cardiac arrhythmia and stent placement. While these drugs have proven, life-saving benefits, they can also cause side effects such as increased bleeding. So it may be a cause for concern if youre taking one of them and you need to have a dental procedure.. Anticoagulants are among the more widely used pharmaceuticals today, particularly for heart patients. Some common prescription anticoagulants include heparin, warfarin (Coumadin and generics), clopidogrel (Plavix) and dabigatran etexilate (Pradaxa). Regular aspirin and NSAIDS (like Advil) also have anticoagulant properties. The purpose of anticoagulant medications is to keep the blood from clotting (clumping together) as readily as it normally does; this reduces the chance of a clot forming inside a blood vessel, which could lead to a ...
Millions of people regularly take anticoagulant or antiplatelet medications (sometimes called "blood thinners") to help prevent heart attack and stroke, and to manage a variety of medical conditions including cardiac arrhythmia and stent placement. While these drugs have proven, life-saving benefits, they can also cause side effects such as increased bleeding. So it may be a cause for concern if youre taking one of them and you need to have a dental procedure.. Anticoagulants are among the more widely used pharmaceuticals today, particularly for heart patients. Some common prescription anticoagulants include heparin, warfarin (Coumadin and generics), clopidogrel (Plavix) and dabigatran etexilate (Pradaxa). Regular aspirin and NSAIDS (like Advil) also have anticoagulant properties. The purpose of anticoagulant medications is to keep the blood from clotting (clumping together) as readily as it normally does; this reduces the chance of a clot forming inside a blood vessel, which could lead to a ...
Millions of people regularly take anticoagulant or antiplatelet medications (sometimes called "blood thinners") to help prevent heart attack and stroke, and to manage a variety of medical conditions including cardiac arrhythmia and stent placement. While these drugs have proven, life-saving benefits, they can also cause side effects such as increased bleeding. So it may be a cause for concern if youre taking one of them and you need to have a dental procedure.. Anticoagulants are among the more widely used pharmaceuticals today, particularly for heart patients. Some common prescription anticoagulants include heparin, warfarin (Coumadin and generics), clopidogrel (Plavix) and dabigatran etexilate (Pradaxa). Regular aspirin and NSAIDS (like Advil) also have anticoagulant properties. The purpose of anticoagulant medications is to keep the blood from clotting (clumping together) as readily as it normally does; this reduces the chance of a clot forming inside a blood vessel, which could lead to a ...
TY - JOUR. T1 - Ependyma-lined canal with surrounding neuroglial tissues in lumbosacral lipomatous malformations. T2 - Relationship with retained medullary cord. AU - Murakami, Nobuya. AU - Morioka, Takato. AU - Shimogawa, Takafumi. AU - Mukae, Nobutaka. AU - Inoha, Satoshi. AU - Sasaguri, Takakazu. AU - Suzuki, Satoshi. AU - Iihara, Koji. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Background: An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear. Method: Six out of 50 patients with lipomatous malformations had ependymal structures. We retrospectively analyzed the clinical, neuroradiological, and histological findings of these patients to demonstrate the relationship with the embryological background of the retained medullary cord (RMC), which normally regresses, but was retained here because of late arrest of secondary neurulation. Results: Five (13.9%) of 36 patients with ...
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1Ospedale Civile Spirito Santo, Pescara, Italy; 2Centro Hospitalar de S o Jo o, Porto, Portugal; 3Medical Center for Infecti ous Diseases, Berlin, Germany; 4University Hospitals KU, Leuven, Belgium; 5Toronto Centre for Liver Disease, University of Toronto, Toronto, Ontario, Canada ...
Dabigatran - Get up-to-date information on Dabigatran side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Dabigatran
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... is a blood thinner used to prevent blood clots and strokes. This eMedTV article offers an in-depth look at this prescription drug, including details on possible side effects, how it works, dosing tips, and what to discuss with your doctor.
1015167-40-4 - CSZFDMHIDSUHPI-KWONYSJQSA-N - Dabigatran 1-acylglucuronide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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2014. Journals. Magrelli, S., Noris, B., Jermann, P., Ansermet, F., Hentsch, F., Nadel, J and Billard, A. (2014) A Wearable Camera Detects Gaze Peculiarities during Social Interactions in Young Children with Pervasive Developmental Disorders. IEEE Transactions on Autonomous Mental Development (TAMD), Volume PP(99). doi: 10.1109/TAMD.2014.2327812. [home page] [pdf] [BibTeX] Lukic, L, Santos-Victor, J. and Billard, A. (2014) Learning robotic eye arm hand coordination from human demonstration: a coupled dynamical systems approach. Biological Cybernetics. [show abstract] [pdf] [BibTeX] Khansari Zadeh, S. M. and Billard, A. (2014) Learning Control Lyapunov Function to Ensure Stability of Dynamical System-based Robot Reaching Motions. Robotics and Autonomous Systems. [home page] [show abstract] [pdf] [BibTeX] Kim, S., Shukla, A. and Billard, A. (2014) Catching Objects in Flight. IEEE Transactions on Robotics, Volume 30, Issue 5. IEEE Transactions on Robotics King-Sun Fu Memorial Best Paper Award 2014. ...
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice.
antithrombin III Glasgow: abnormal antithrombin with increased heparin affinity & reduced ability to inactivate thrombin; associated with familial thrombosis; tryptic peptides Ala(371)-Arg(393) & Ser(394)-Arg(399) present in reduced amounts; Asp(187) replaced by Lys
As the search for survivors at an Italian hotel buried during an avalanche continues, an investigation has been launched into a distress call and emails for help by the hotels owner. Triggered by a series of earthquakes, the avalanche claimed the lives of at least 14 people, with 15 still missing, according to reports. A staff of eight and 20 guests were reported to have been at the hotel at the time.. Bruno Di Tommaso, owner of hotel Rigopiano, a popular ski resort, reportedly sent an email asking for help from authorities in the nearby town of Pescara. "The phones are out of service. Customers are terrified by the earthquakes and have decided to stay outdoors. We tried to do everything possible to calm them but, unable to leave because of blocked roads, they are willing to spend the night in the car," his email read. "With our shovels we were able to clean the driveway, from the gate to the SS42 (state road). Aware of the general difficulties, we ask you to intervene.". The UKs Telegraph ...
RE-LY臨床試驗顯示亞洲病人的中風或SE年發生率分別為warfarin組3.06%、dabigatran 110組2.50%、dabigatran 150組1.39%;若統計缺血性中風的年發生率,warfarin組為2.02%,dabigatran 150組則為1.12%;重大出血年發生率則分別為dabigatran 110組 2.22%、 dabigatran 150組 2.17%、warfarin組 3.82%。專家認為dabigatran可在更安全的條件下預防中風。雖然這項針對亞洲病人的研究有些限制,包括與非亞洲族群相比年紀較輕、INR控制較差、中風病史較多,且各國受試者之間飲食和生活差距很大,但整體而言,研究明確顯示亞洲病人使用warfarin的出血風險較高,而dabigatran未來可望成為亞洲病人預防中風的新選擇 ...
NPC313Hu01, AT3; ATIII; SERPINC1; Anti-Thrombin Antibodies; Serpin Peptidase Inhibitor Clade C Member 1; Coding Sequence Signal Peptide Antithrombin Part 1 | Products for research use only!
This unit describes the purification of extracellular vitronectin from plasma or serum by using heparin‐affinity chromatography
Stoptheclots.com is an online resource for patients, family members and caregivers. The information should never be used in lieu of a doctors advice.
Dabigatran is a direct thrombin inhibitor and an anticoagulant that is prescribed to prevent ischemic stroke and systemic embolism in non-valvular atrial fibrillation. Dabigatran (150 mg twice daily) is non-inferior to warfarin for the prevention of stroke and systemic embolism. A dose reduction to 110 mg twice daily should be considered for patients with decreased renal function, elderly patients, and those with a history of gastrointestinal bleeding. A small number of patients are prescribed 75 mg twice daily; however, excessive dose reduction below that indicated on the package insert may decrease the effectiveness of dabigatran. In this study, we investigated the incidence of thromboembolic events and hemorrhagic complications in patients receiving different doses of dabigatran, including patients receiving the very low-dose of 75 mg twice daily. Five hospitals in Meguro and Setagaya areas of Tokyo were included in this study. The subjects were patients receiving dabigatran in the hospitals from
The Journal of Osseointegration is an international journal publishing frontier articles on all the latest advances in basic science related to osseointegration. The Journal of Osseointegration aims to become essential for all scientists who wish to keep abreast of rapid and important developments in the field. The Journal focuses on the publication and critical evaluations of clinical and basic science research; clinical case reports will also be considered.. Papers submitted are subjected to peer-reviewing and processed rapidly, taking full advantage of internet technology for submission. Manuscript submission will be managed completely on-line. In the journals web site at www.journalofosseointegration.eu you can find all details, including:. ...
TY - JOUR. T1 - Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. AU - Miyamoto, Kana. AU - Yoshida, Shigeyuki. AU - Kawasumi, Miyuri. AU - Hashimoto, Kazuaki. AU - Kimura, Tokuhiro. AU - Sato, Yuiko. AU - Kobayashi, Tami. AU - Miyauchi, Yoshiteru. AU - Hoshi, Hiroko. AU - Iwasaki, Ryotaro. AU - Miyamoto, Hiroya. AU - Hao, Wu. AU - Morioka, Hideo. AU - Chiba, Kazuhiro. AU - Kobayashi, Takashi. AU - Yasuda, Hisataka. AU - Penninger, Josef M.. AU - Toyama, Yoshiaki. AU - Suda, Toshio. AU - Miyamoto, Takeshi. PY - 2011/12/19. Y1 - 2011/12/19. UR - http://www.scopus.com/inward/record.url?scp=84862936378&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84862936378&partnerID=8YFLogxK. U2 - 10.1084/jem.2010189020813c. DO - 10.1084/jem.2010189020813c. M3 - Article. AN - SCOPUS:84862936378. VL - 208. SP - 2761. JO - Journal of Experimental Medicine. JF - Journal of Experimental Medicine. SN - 0022-1007. IS - 13. ER - ...
As the search for survivors at an Italian hotel buried during an avalanche continues, an investigation has been launched into a distress call and emails for help by the hotels owner. Triggered by a series of earthquakes, the avalanche claimed the lives of at least 14 people, with 15 still missing, according to reports. A staff of eight and 20 guests were reported to have been at the hotel at the time.. Bruno Di Tommaso, owner of hotel Rigopiano, a popular ski resort, reportedly sent an email asking for help from authorities in the nearby town of Pescara. "The phones are out of service. Customers are terrified by the earthquakes and have decided to stay outdoors. We tried to do everything possible to calm them but, unable to leave because of blocked roads, they are willing to spend the night in the car," his email read. "With our shovels we were able to clean the driveway, from the gate to the SS42 (state road). Aware of the general difficulties, we ask you to intervene.". The UKs Telegraph ...
RE-LY is the largest randomized experience reporting outcomes after interruption of anticoagulant therapy.1 There was no excess of bleeding in patients taking dabigatran, including those having major or urgent surgery.1 David and colleagues correctly state that the majority of procedures performed during the RE-LY trial were minor. Nonetheless, our analysis included 1482 major procedures that had a 6% to 8% rate of major bleeding,1 which was numerically lower among dabigatran-treated patients.1. Hjemdahl et al opine that the high rate of major bleeding in RE-LY patients assigned to dabigatran 150 mg twice daily who had interruption for ,72 hours before surgery suggests accumulation of dabigatran in patients with renal impairment. However, data from RE-LY do not support this interpretation, because the same pattern of bleeding based on the timing of study drug interruption was seen in the subgroup of patients with an estimated creatinine clearance of ,60 mL/min. Instead, we believe that the ...
No sex-related difference is noted in terms of the prevalence of congenital antithrombin III deficiency. Women of childbearing age present special risk factors. Antithrombin III deficiency, like other... more
The title compound, C17H16N2O4S2H2O, is of inter-est regarding its anti-obesity and anti-diabetic activity. = 15.676 (3) ? = 3694.0 (14) ?3 = 8 Mo = 273 K 0.29 0.21 0.17 mm Data collection Bruker SMART APEX CCD area detector diffractometer Absorption modification: multi-scan (> 2(= 1.09 3255 reflections 236 parameters H-atom parameters constrained max = 0.39 e ??3 min = ?0.27 e ??3 Data collection: (Bruker, 2000 ?); cell refinement: (Bruker, 2001 ?); data decrease: (Sheldrick, 2008 ?); plan(s) utilized to refine framework: (Spek, 2009 ?), (Bergerhoff BIIB-024 (Westrip, 2010 ?). ? Desk 1 Hydrogen-bond geometry (?, ) Supplementary Materials Crystal framework: contains datablocks I, global. DOI: 10.1107/S1600536810039279/jh2215sup1.cif Just click here to see.(21K, cif) Framework elements: contains datablocks We. DOI: 10.1107/S1600536810039279/jh2215Isup2.hkl Just click here to see.(160K, hkl) Additional supplementary components: crystallographic details; 3D watch; checkCIF survey Acknowledgments ...
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In this latest Missouri Medicine article, Richard J Weachter, MD, details the pros and cons of new blood thinner drug Dabigatran (Pradaxa).
Antithrombin-III. *Lipoprotein lipase. *Apolipoproteins. *Growth factors. *Chemokines. The enzymes and proteins listed above ... The glycocalyx also consists of a wide range of enzymes and proteins that regulate leukocyte and thrombocyte adherence, since ... and includes enzymes secreted by the absorptive cells that are essential for the final steps of digestion of proteins and ... Membrane proteins. *Membrane glycoproteins. *Integral membrane proteins/transmembrane protein. *Peripheral membrane protein/ ...
Antithrombin protein therapeuticsEdit. The antithrombin protein itself is used as a protein therapeutic that can be purified ... It works by activating antithrombin III, which blocks thrombin from clotting blood. Heparin can be used in vivo (by injection ... Antithrombin is approved by the FDA as an anticoagulant for the prevention of clots before, during, or after surgery or ... Apart from heparin, most of these chemicals work by binding calcium ions, preventing the coagulation proteins from using them. ...
Notes: Rat proteins were used for the assays. Sources: [21][22][23] ... Hypothalamic protein levels in the gene COMT are enhanced by increasing estrogen levels which are believed to return mice that ... The actions of estrogen are mediated by the estrogen receptor (ER), a dimeric nuclear protein that binds to DNA and controls ... Estrogens are plasma protein bound to albumin and/or sex hormone-binding globulin in the circulation. ...
Some examples of heparin binding proteins include antithrombin III. It is thought that much protein interaction with heparin is ... One counter example is the protein chymase, which directly binds to heparin. Dermatan sulfate is one example of a compound that ... Heparinoids, like heparin, act by interacting with heparin binding proteins, generally through ionic interactions or hydrogen ... so it is possible that heparinoids interact with these proteins in a similar way, acquiring GAG side chains in vivo. ...
Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels of ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is commonly included in linker regions of recombinant fusion protein ...
... (TAT) is a protein complex of thrombin and antithrombin. Lippi G, Cervellin G, Franchini M, ...
Protein S, an anticoagulant, decreases. However, the other major anticoagulants, protein C and antithrombin III, remain ... proteins C and S deficiencies, and antithrombin III deficiency. Hypercoagulability in pregnancy, particularly due to ...
Antithrombin is an anticoagulant protein and is important in preventing blood clotting. In animal studies, Antithrombin in ... Antithrombin: the levels of antithrombin increase with age. Antithrombin levels in newborns are less than 50% of the levels in ... Protein C is active in anticoagulation (anti-clotting) and breaking down blood clots. A newborn form of protein C has been ... There is an increase in the concentration of a specific isoform of Antithrombin, Latent Antithrombin with age. This form of ...
Hunt LT, Dayhoff MO (July 1980). "A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1- ... The serpin barley protein Z is highly abundant in barley grain, and one of the major protein components in beer. The genome of ... where X is the clade of the protein and Y the number of the protein within that clade. The functions of human serpins have been ... "Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation". The EMBO Journal. ...
This protein shares homology with antithrombin and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a ... Pizzo SV (1989). "Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes". ...
It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic ... It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make ...
Deficiencies in antithrombin, protein C, and protein S are rare but strong, or moderately strong, risk factors. These three ... For populations in China, Japan, and Thailand, deficiences in protein S, protein C, and antithrombin predominate. Non-O blood ... The term 'thrombophilia' as used here applies to the five inherited abnormalities of antithrombin, protein C, protein S, factor ... Genetic factors include deficiencies of antithrombin, protein C, and protein S, and factor V Leiden mutation. The underlying ...
... protein C deficiency, protein S deficiency, antithrombin deficiency) ... Estrogens have effects on liver protein synthesis, including on the synthesis of plasma proteins, coagulation factors, ... Protein binding. Estradiol: ~98% (to albumin and SHBG)[3][4][1]. Metabolism. Mainly in the liver, to a lesser extent in the ... Stege R, Fröhlander N, Carlström K, Pousette A, von Schoultz B (1987). "Steroid-sensitive proteins, growth hormone and ...
... resulting in decreased synthesis of the regulatory proteins antithrombin, protein C and protein S, with increased synthesis of ... Acquired protein C deficiency is caused by either depletion of available protein C in plasma or decreased protein C synthesis ( ... The depletion of anticoagulant and anti-inflammatory proteins, in particular, protein C and its co-factor, protein S, may also ... Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S, International ...
The drug is called ATryn, which is antithrombin protein purified from the milk of genetically modified goats. Marketing ... Many proteins of interest are too complex to be made by microbial systems or by protein synthesis. These proteins are currently ... Additionally, on the level of pharmacologically active proteins, there are no proteins in plants that are similar to human ... Blood, for instance, as of 2012 cannot store high levels of stable recombinant proteins, and biologically active proteins in ...
Aptamer Deoxyribozyme Anti-thrombin aptamers Bacterial one-hybrid system Oliphant, AR; Brandl, CJ; Struhl, K (1989). "Defining ... Paige, J. S.; Wu, K. Y.; Jaffrey, S. R. (2011). "RNA Mimics of Green Fluorescent Protein". Science. 333 (6042): 642-646. doi: ... Mercey, R; Lantier, I; Maurel, MC; Grosclaude, J; Lantier, F; Marc, D (2006). "Fast, reversible interaction of prion protein ... Blackwell, TK; Weintraub, H (1990). "Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes ...
The term alpha-1 refers to the protein's behavior on protein electrophoresis. On electrophoresis, the protein component of the ... An extremely rare form of Pi, termed PiPittsburgh, functions as an antithrombin (a related serpin), due to a mutation ( ... which could confer this protein particular protein-cell recognition properties. The single cysteine residue of A1AT in position ... As protein electrophoresis is imprecise, the A1AT phenotype is analysed by isoelectric focusing (IEF) in the pH range 4.5-5.5, ...
... protein S deficiency, the Factor V Leiden mutation, hereditary anti-thrombin deficiency and prothrombin mutation G20210A. An ... Examples of genetic tendencies include protein C deficiency, ...
... a plasma protein with anticoagulant properties. Microinjection was used to insert human antithrombin genes into the cell ... GTC states that one genetically modified goat can produce the same amount of antithrombin in a year as 90,000 blood donations. ... GTC chose goats for the process because they reproduce more rapidly than cattle and produce more protein than rabbits or mice. ... Soler E, Thépot D, Rival-Gervier S, Jolivet G, Houdebine LM (2006). "Preparation of recombinant proteins in milk to improve ...
Screening for protein C, protein S, or antithrombin III deficiency is sometimes recommended but these are more usually ...
A fibrin scaffold is a network of protein that holds together and supports a variety of living tissues. It is produced ... Heparin binding sequences KβAFAKLAARLYRKA, RβAFARLAARLYRRA, KHKGRDVILKKDVR, YKKIIKKL are from antithrombin III, modified ... Collagen originated sequence is DGEA and many other ECM protein originated RGD sequence can be given as other examples. ... Fibrin consists of the blood proteins fibrinogen and thrombin which participate in blood clotting. Fibrin glue or fibrin ...
To rule out other causes for hypercoagulation, it may be appropriate to check the antithrombin, protein C, protein S, factor V ...
... activated protein C resistance (Factor V Leiden) and antithrombin III deficiency. Although the above theory is the most ... Protein C is an innate anticoagulant, and as warfarin further decreases protein C levels, it can lead to massive thrombosis ... "Replacement therapy with a purified protein C concentrate during initiation of oral anticoagulation in severe protein C ... In warfarin's initial stages of action, inhibition of protein C and Factor VII is stronger than inhibition of the other vitamin ...
In this case, patients should keep an eye out and maintain reduced level of proteinuria by reducing salt and excess protein, ... and a decrease in coagulation inhibiters like antithrombin. Hypercoagulability can be inherited and/or acquired. ... The increased loss of proteins in the urine caused by nephrotic syndrome results in lower osmotic pressure. Reduced osmotic ... Nephrotic syndrome, a kidney disorder, causes excessive loss of protein in the urine, hypoalbuminemia, hypercholesterolemia and ...
These include the evaluation of the thrombin-antithrombin complexes (TAT), low levels of the anticoagulants ATIII and protein C ... Preventing blood clots includes the use of medications that interrupt the complex clotting cascade and changing the proteins ...
Antithrombin (inhibits II, IX, X, XI, XII). *Protein C (inhibits V, VIII)/Protein S (cofactor for protein C) ...
No sex-related difference is noted in terms of the prevalence of congenital antithrombin III deficiency. Women of childbearing ... it is important to consider antithrombin III deficiency, along with protein C or protein S deficiency and AP antibody syndrome. ... Antithrombin-a for the prophylaxis of venous thrombosis in congenital antithrombin deficiency. Expert Rev Hematol. 2009 Oct. 2( ... Role of antithrombin concentrate in treatment of hereditary antithrombin deficiency. An update. Thromb Haemost. 2009 May. 101(5 ...
LSBio Antithrombin-III Proteins [LifeSpan BioSciences, Inc.] LSBio Antithrombin-III Proteins. LifeSpan BioSciences, Inc. ... The complete amino acid sequence of bovine antithrombin (ATIII). [J Protein Chem. 1991] The complete amino acid sequence of ... LSBio Antithrombin-III Elisa Kits [LifeSpan BioSciences, Inc.] LSBio Antithrombin-III Elisa Kits. LifeSpan BioSciences, Inc. ... LSBio Antithrombin-III Antibodies [LifeSpan BioSciences, Inc.] LSBio Antithrombin-III Antibodies. LifeSpan BioSciences, Inc. ...
Estimating glycosaminoglycan-protein interaction affinity: water dominates the specific antithrombin-heparin interaction. ... In summary, we have identified and optimized a reliable method for estimation of GAG-protein binding affinity, and shown that ... Glycosaminoglycan (GAG)-protein interactions modulate many important biological processes. Structure-function studies on GAGs ... alchemical free-energy perturbation protocol that estimates changes in affinity for the prototypical heparin-antithrombin ...
... has been shown to interfere with the heparin-catalysed inhibition of thrombin by antithrombin III. This interaction was further ... S protein, a plasma glycoprotein with Mr 78,000, ... 0/S-protein (control); 9000-94-6/Antithrombin III; EC 3.4.21.5/ ... Owing to the association of S protein with the thrombin-antithrombin III (TAT) complex, the STAT complex assembled in vitro ... This observation indicated the formation of a ternary S protein-thrombin-antithrombin III (STAT) complex in serum. This complex ...
Abstract-Deficiencies of antithrombin (AT), protein C (PC) or protein S (PS), and activated protein C resistance (APCR) are ... Risk of Venous Thromboembolism and Clinical Manifestations in Carriers of Antithrombin, Protein C, Protein S Deficiency, or ... Risk of Venous Thromboembolism and Clinical Manifestations in Carriers of Antithrombin, Protein C, Protein S Deficiency, or ... Risk of Venous Thromboembolism and Clinical Manifestations in Carriers of Antithrombin, Protein C, Protein S Deficiency, or ...
Among the causes, predisposing an individual to CTPV is natural anticoagulant protein C and antithrombin III deficiencies. ... We discuss a case of a nine-year-old male child diagnosed as CTPV secondary to protein C and antithrombin III deficiency who ... Cavernous Transformation of Portal Vein in the Setting of Protein C and Anti-thrombin III Deficiency Mahwish Nasim , Bushra ... We discuss a case of a nine-year-old male child diagnosed as CTPV secondary to protein C and antithrombin III deficiency who ...
IMMOBILIZED PROTEINS Immobilized human antithrombin \ HATIII-I for more molecular products just contact us ... WP1256: NLR proteins. WP1294: NLR proteins. WP1360: NLR proteins. WP163: Cytoplasmic Ribosomal Proteins. WP1780: ABC-family ... IMMOBILIZED PROTEINS Immobilized human antithrombin. Related products : IMMOBILIZED PROTEINS Immobilized human antithrombin ... WP30: Cytoplasmic Ribosomal Proteins. WP324: Cytoplasmic Ribosomal Proteins. WP477: Cytoplasmic Ribosomal Proteins. Related ...
The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link ... Antithrombin Human (Homo sapiens) [TaxId: 9606] L. d1dzgl_. Multi-domain proteins (alpha and beta) Serpins Serpins Serpins ... Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 L1. 1dzgL01. Mainly Beta Roll Alpha-1-antitrypsin; domain 1 ... Protein Family Annotation Pfam Database Homepage. Chains. Pfam Accession. Pfam Identifier. Pfam Description. Type. Source. ...
Antithrombin III is a serum protease inhibitor that inhibits the blood coagulation protease, thrombin, and is an important ... Scripps Laboratories is a world-leading producer and supplier of purified human Antithrombin III. Liquid and lyophilized ... Clinical conditions associated with low levels of Antithrombin III are venous thromboembolism and liver disease. Elevated ... Manufacturers of the Highest Quality Proteins & Antibodies. * CALL US ON (+1) 858-546-5800 ...
Browse our Serpin C1/Antithrombin-III all backed by our Guarantee+. ... Serpin C1/Antithrombin-III available through Novus Biologicals. ... Protein Or Peptide. *. Recombinant Protein Antigen (2). *. ... ":"Protein A purified","Activity":"","Accession #":"","N-terminal Sequence Analysis":"","Predicated Molecular Mass":"","SDS ...
Antithrombin protein therapeuticsEdit. The antithrombin protein itself is used as a protein therapeutic that can be purified ... It works by activating antithrombin III, which blocks thrombin from clotting blood. Heparin can be used in vivo (by injection ... Antithrombin is approved by the FDA as an anticoagulant for the prevention of clots before, during, or after surgery or ... Apart from heparin, most of these chemicals work by binding calcium ions, preventing the coagulation proteins from using them. ...
The deduced protein BjATl consisted of 338 amino acids sharing 36.7% to 41.1% identity to known vertebrate ATs. BjATl contains ... Antithrombin (AT) is a member of the serine protease inhibitor superfamily and a major coagulation inhibitor in all vertebrates ... In this study we isolated for the first time a cDNA encoding an antithrombin homolog, BjATl, from the protochordate ... are a group of widely distributed proteins with similar structures that use conformational change to inhibit proteases. ...
The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and ... supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein ... A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, ... the coagulation proteins (antithrombin III, prothrombin, plasminogen, antiemophilic factor-factor VIII, fibrin-stabilizing ...
... to reduced production or loss of the protein in the urine. ... If the antithrombin activity is low, it should be repeated to ... Antithrombin activity is preferred over antithrombin antigen assays, as activity assays detect both low levels of antithrombin ... Antithrombin activity is preferred over antithrombin antigen assays as activity assays detect both low levels of antithrombin ... Antithrombin levels are remarkably similar in all humans. The antithrombin concentration in blood does not vary to a ...
The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link ... Protein Atoms. 6412. Nucleic Acid Atoms. 0. Heterogen Atoms. 160. Solvent Atoms. 37. ... 5MG/ML 1:1 MIX OF INHIBITORY: LATENT ANTITHROMBIN-III, 10.5% PEG 4000, 65 MM NACACODYLATE, PH 6.5. ...
Yet another preferred group of blood proteins include proteins found in commercially available plasma protein fraction products ... anti-thrombin-3; alpha-glucosidase: (fetal) bovine serum/horse serum; meat; immunoglobulins, including anti-sera, monoclonal ... 4,620,908 discloses that protein products must be frozen prior to irradiation in order to maintain the viability of the protein ... As used herein, the term "blood protein" is intended to mean one or more of the proteins that are normally found in whole blood ...
Protein Feature View. ( Mouse scroll to zoom / Hold left click to move ) ... ANTITHROMBIN. I, L. 432. Homo sapiens. Mutation(s): 0 Gene Names: SERPINC1, AT3, PRO0309. ... The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.. Skinner, R., Abrahams, J.P. ... THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE. *DOI: 10.2210/pdb2ANT/pdb ...
Blood Protein Disorders. Thrombophilia. Genetic Diseases, Inborn. Thrombin. Antithrombins. Antithrombin III. Hemostatics. ... Experimental: Anti-thrombin III Drug: Anti-thrombin III Intraoperatively- (correcting to 100%) according to the following ... Genetics Home Reference related topics: Hereditary antithrombin deficiency Drug Information available for: Antithrombin III ... Anti-thrombin III (ATIII) vs Placebo in Children (,7mo) Undergoing Open Congenital Cardiac Surgery. The safety and scientific ...
One important protein that helps clotting is thrombin. The protein that blocks thrombin is called antithrombin. Antithrombin ... But much of that protein doesnt work the way it should. The antithrombin antigen test measures how much antithrombin protein ... This problem is caused by a defect in the antithrombin protein. No evidence exists that higher-than-normal antithrombin levels ... The antithrombin activity test measures how well the protein inhibits thrombin. As explained below, the two tests can be used ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ... Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ... Recombinant factor VIII Fc fusion protein for the treatment of severe haemophilia A: Final results from the ASPIRE extension ...
APC = activated protein C (APC); AT-III = antithrombin III; FDP = fibrin degradation products; HC-II = heparin cofactor II; ... Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A. Blood. 2014 Jan 16. 123(3):317-25. [Medline] ... FDA approves the first antihemophilic factor, Fc fusion protein for patients with Hemophilia A. U.S. Food and Drug ...
  • In order to assess whether the HR2 haplotype of the factor V gene (HR2) increases the risk of venous thromboembolism (VTE) in carriers of antithrombin (AT), protein C (PC) or S (PS) defects, we performed this determination in 336 subjects, who were family members of 66 symptomatic patients with clotting inhibitors defects. (cdc.gov)
  • The actions of estrogen are mediated by the estrogen receptor (ER), a dimeric nuclear protein that binds to DNA and controls gene expression. (wikipedia.org)
  • Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins? (cdc.gov)
  • This validation study suggested LARGE, a gene encoding a protein with xylosyltransferase and glucuronyltransferase activities that forms heparin-like linear polysaccharides, as a potential modulator of antithrombin based on the significant association of one SNPs, rs762057, with anti-FXa activity, particularly after adjustment for age, sex and SERPINC1 rs2227589 genotype, all factors influencing antithrombin levels (p = 0.02). (cdc.gov)
  • It is estimated that plasma may contain as many as 40,000 different proteins from about 500 gene products. (sigmaaldrich.com)
  • Hundreds of natural mutations of the protein C gene (PROC) have been identified. (wikipedia.org)
  • Because A1AT is expressed in the liver, certain mutations in the gene encoding the protein can cause misfolding and impaired secretion, which can lead to liver cirrhosis. (wikipedia.org)
  • In humans, protein S is encoded by the PROS1 gene. (wikipedia.org)
  • Identification of antithrombin-modulating genes. (cdc.gov)
  • The haemostatic relevance of antithrombin together with the low genetic variability of SERPINC1, and the high heritability of plasma levels encourage the search for modulating genes. (cdc.gov)
  • We used a hypothesis-free approach to identify these genes, evaluating associations between plasma antithrombin and 307,984 polymorphisms in the GAIT study (352 individuals from 21 Spanish families). (cdc.gov)
  • Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos. (wikipedia.org)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • If the protein S or C shortage is due to a rare inherited genetic change, the quantity of protein C or protein S available and the degree of activity can be used to help determine whether a person has one copy (heterozygous) or two copies (homozygous) of the mutation. (labcorp.com)
  • The physiological role of decreased synthesis of such proteins is generally to save amino acids for producing "positive" acute-phase proteins more efficiently. (wikipedia.org)
  • HS synthesis initiates with the transfer of xylose from UDP-xylose by xylosyltransferase (XT) to specific serine residues within the protein core. (wikipedia.org)
  • Hyperlipidaemia is caused by two factors: Hypoproteinemia stimulates protein synthesis in the liver, resulting in the overproduction of lipoproteins. (wikipedia.org)
  • A hypoalbuminemia of less than 2.5 g/dL, that exceeds the hepatic clearance level, that is, protein synthesis in the liver is insufficient to increase the low blood protein levels. (wikipedia.org)
  • Construction of a tetrasaccharide linker that consists of -GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-(Ser)-, where xylosyltransferase, β4-galactosyl transferase (GalTI),β3-galactosyl transferase (GalT-II), and β3-GlcA transferase (GlcAT-I) transfer the four monosaccharides, begins synthesis of the GAG modified protein. (wikipedia.org)
  • The STAT complex could be detected in serum at a dilution of 1:3200 by a sensitive immuno-radiometric assay employing affinity-purified IgG against S protein. (biomedsearch.com)
  • LARGE silencing inHepG2 and HEK-EBNA cells did not affect SERPINC1 mRNA levels but significantly reduced the secretion of antithrombin with moderate intracellular retention. (cdc.gov)