Antithrombin iii deficiency. Medical search

An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

Formation and development of a thrombus or blood clot in the blood vessel.

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.

An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.

Cytochromes of the b group that have alpha-band absorption of 563-564 nm. They occur as subunits in MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III.

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.

Inflammation of a vein associated with a blood clot (THROMBUS).

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.

Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

Surgery performed on the heart.

The natural enzymatic dissolution of FIBRIN.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.

Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.

A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.

The formation or presence of a blood clot (THROMBUS) within a vein.

Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.

A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.

Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.

Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.

A compound that, along with its isomer, Cleland's reagent (DITHIOTHREITOL), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups.

A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Familial overexpression of beta antithrombin caused by an Asn135Thr substitution. (1/74)

We have investigated the basis of antithrombin deficiency in an asymptomatic individual (and family) with borderline levels (approximately 70% antigen and activity) of antithrombin. Direct sequencing of amplified DNA showed a mutation in codon 135, AAC to ACC, predicting a heterozygous Asn135Thr substitution. This substitution alters the predicted consensus sequence for glycosylation, Asn-X-Ser, adjacent to the heparin interaction site of antithrombin. The antithrombin isolated from plasma of the proband by heparin-Sepharose chromatography contained amounts of beta antithrombin (the very high affinity fraction) greatly increased (approximately 20% to 30% of total) above the trace levels found in normals. Expression of the residue 135 variant in both a cell-free system and COS-7 cells confirmed altered glycosylation arising as a consequence of the mutation. Wild-type and variant protein were translated and exported from COS-7 cells with apparently equal efficiency, in contrast to the reduced level of variant observed in plasma of the affected individual. This case represents a novel cause of antithrombin deficiency, removal of glycosylation concensus sequence, and highlights the potentially important role of beta antithrombin in regulating coagulation. (+info)

Plasma antithrombin III deficiency in ischaemic stroke in the young. (2/74)

A deficiency of plasma antithrombin III has been identified as a potential risk factor for thrombosis. In a pilot study of 56 patients aged less than 40 years who presented with ischaemic stroke of unknown etiology, we detected only one case of plasma antithrombin III deficiency. Antithrombin III activity was estimated by a chromogenic assay. Hence, antithrombin III deficiency, though rare, should be considered while evaluating young patients with stroke of unknown etiology. (+info)

Enhancement of heparin cofactor II anticoagulant activity. (3/74)

Heparin cofactor II (HCII) is a serpin whose thrombin inhibition activity is accelerated by glycosaminoglycans. We describe the novel properties of a carboxyl-terminal histidine-tagged recombinant HCII (rHCII-CHis(6)). Thrombin inhibition by rHCII-CHis(6) was increased >2-fold at approximately 5 microgram/ml heparin compared with wild-type recombinant HCII (wt-rHCII) at 50-100 microgram/ml heparin. Enhanced activity of rHCII-CHis(6) was reversed by treatment with carboxypeptidase A. We assessed the role of the HCII acidic domain by constructing amino-terminal deletion mutants (Delta1-52, Delta1-68, and Delta1-75) in wt-rHCII and rHCII-CHis(6). Without glycosaminoglycan, unlike wt-rHCII deletion mutants, the rHCII-CHis(6) deletion mutants were less active compared with full-length rHCII-CHis(6). With glycosaminoglycans, Delta1-68 and Delta1-75 rHCIIs were all less active. We assessed the character of the tag by comparing rHCII-CHis(6), rHCII-CAla(6), and rHCII-CLys(6) to wt-rHCII. Only rHCII-CHis(6) had increased activity with heparin, whereas all three mutants have increased heparin binding. We generated a carboxyl-terminal histidine-tagged recombinant antithrombin III to study the tag on another serpin. Interestingly, this mutant antithrombin III had reduced heparin cofactor activity compared with wild-type protein. In a plasma-based assay, the glycosaminoglycan-dependent inhibition of thrombin by rHCII-CHis(6) was significantly greater compared with wt-rHCII. Thus, HCII variants with increased function, such as rHCII-CHis(6), may offer novel reagents for clinical application. (+info)

The prevalence of hereditary thrombophilia in the Trakya region of Turkey. (4/74)

The prevalences of deficiencies in antithrombin III (AT III), protein C (PC), protein S (PS) and in the activated protein C (APC) resistance in the thrombotic population of the Trakya region, Turkey were investigated. 37 patients with venous thrombosis (VT) and 17 patients with arterial thrombosis (ArT) were included in this study. The mean ages of the patients with VT and ArT were 46 years (range 20-70) and 38 years (range 32-40), respectively. The activity of AT III was measured by commercially available immuno-turbidimetric assay. The activities of PC and PS were determined by coagulometric assay. The APC resistance was measured using a modified APTT-based clotting assay. Among the VT patients, there were 2 cases (5.4%) with AT III, 5 (13.51%) with PC deficiency, 5 (13.51%) with PS deficiency and 2 (5.4%) with APC resistance. In the ArT patient group, there was 1 patient (5.88%) with AT III, 3 (17.64%) with PC deficiency, 1 (5.88%) with PS deficiency and no APC resistant patients, while there was one (2.08%) with PC deficiency and one (2.08%) with APC resistance in the control group (49 persons, mean age 41 years). The relative risk of thrombosis (odds ratio) was 1.7 in the deficiency of PC and 5.6 in the deficiency of PS. The data presented suggests that the prevalences of AT III, PC and PS deficiencies causing thrombophilia in the Trakya region of Turkey are higher than in other reported studies while the APC resistance is lower than in others. Further studies including more patients would be required to clarify these discrepancies. (+info)

Complete antithrombin deficiency in mice results in embryonic lethality. (5/74)

Antithrombin is a plasma protease inhibitor that inhibits thrombin and contributes to the maintenance of blood fluidity. Using targeted gene disruption, we investigated the role of antithrombin in embryogenesis. Mating mice heterozygous for antithrombin gene (ATIII) disruption, ATIII(+/-), yielded the expected Mendelian distribution of genotypes until 14.5 gestational days (gd). However, approximately 70% of the ATIII(-/-) embryos at 15.5 gd and 100% at 16.5 gd had died and showed extensive subcutaneous hemorrhage. Histological examination of those embryos revealed extensive fibrin(ogen) deposition in the myocardium and liver, but not in the brain or lung. Furthermore, no apparent fibrin(ogen) deposition was detected in the extensive hemorrhagic region, suggesting that fibrinogen might be decreased due to consumptive coagulopathy and/or liver dysfunction. These findings suggest that antithrombin is essential for embryonic survival and that it plays an important role in regulation of blood coagulation in the myocardium and liver. (+info)

Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. (6/74)

BACKGROUND AND PURPOSE: One or more of the inherited thrombophilias may be causal risk factor for a proportion of ischemic strokes, but few studies have addressed this association or the association between thrombophilia and pathogenic subtypes of stroke. METHODS: We conducted a case-control study of 219 hospital cases with a first-ever ischemic stroke and 205 randomly selected community control subjects stratified by age, sex, and postal code. With the use of established criteria, cases of stroke were classified by pathogenic subtype in a blinded fashion. The prevalence of conventional vascular risk factors; fasting plasma levels of protein C, protein S, antithrombin III; and genetic tests for the factor V Leiden and the prothrombin 20210A mutation were determined in cases and control subjects. RESULTS: The prevalence of any thrombophilia was 14.7% (95% CI, 9.9% to 19.5%) among cases and 11.7% (95% CI, 7.4% to 17.0%) among control subjects (OR, 1.3; 95% CI, 0.7% to 2.3%). The prevalence of individual thrombophilias among cases ranged from 0.9% (95% CI, 0.1% to 3.4%) for protein S deficiency to 5.2% (95% CI, 0.3% to 9.1%) for antithrombin III deficiency; among control subjects, the prevalence ranged from 1.0% (95% CI, 0.1% to 3.6%) for protein S deficiency to 4.1% (95% CI, 0.2% to 7.8%) for antithrombin III deficiency. There were no significant differences in the prevalence of thrombophilia between cases and control subjects or between pathogenic subtypes of ischemic stroke. CONCLUSIONS: One in 7 patients with first-ever acute ischemic stroke will test positive for one of the inherited thrombophilias, but the relation is likely to be coincidental rather than causal in almost all cases, irrespective of the pathogenic subtype of the ischemic stroke. These results suggest that routine testing for thrombophilia in most patients with acute ischemic stroke may be unnecessary. Whether the thrombophilias may still be important in younger patients with ischemic stroke or in predicting complications (eg, venous thrombosis) and stroke outcome remains uncertain. (+info)

Mesenteric venous thrombosis: a changing clinical entity. (7/74)

OBJECTIVE: Mesenteric venous thrombosis (MVT) and its clinical spectrum have become better defined following improvements in diagnostic imaging. Historically, MVT has been described as a morbid clinical entity, but this may not necessarily be true. Often, an underlying disease process that predisposes a patient to MVT can be found and potentially treated. This study was designed to evaluate the diagnostics and management of MVT and to review long-term results of treatment. PATIENTS: Thirty-one patients in whom MVT was diagnosed between 1985 and 1999 were retrospectively reviewed. Survivors were contacted for follow-up. There were 15 men and 16 women. Ages ranged from 22 to 80 years (mean, 49.1 years). Thirteen patients had documented hypercoagulability, 10 had a history of previous abdominal surgery, 6 had a prior thrombotic episode, and 4 had a history of cancer. MVT presented as abdominal pain (84%), diarrhea (42%), and nausea/vomiting (32%). Computed tomography (CT) was considered diagnostic in 18 (90%) of 20 patients who underwent the test. CT diagnosed MVT in 15 (100%) of 15 patients presenting with vague abdominal pain or diarrhea. Angiography demonstrated MVT in only five (55.5%) of nine patients. RESULTS: Seven of 31 patients died within 30 days (< 30-day mortality rate, 23%). Twenty-two patients (72%) were initially treated with heparin. Nine patients were not heparinized: four of them died, and two were later given warfarin sodium (Coumadin). Of the 31 patients, only one received lytic therapy. Three patients became symptom free without anticoagulation. Ten patients (32%) underwent bowel resection. Overall, 19 (79%) of 24 survivors were treated with long-term warfarin therapy. Long-term follow-up was obtained in 24 patients (mean, 57.7 months). Twenty-one (88%) of 24 survived in follow-up. CONCLUSION: The diagnosis of MVT should be suspected when acute abdominal symptoms develop in patients with prior thrombotic episodes or a documented coagulopathy. CT scanning appears to be the primary diagnostic test of choice. Anticoagulation is recommended. If diagnosed and treated early, MVT is not likely to progress to gangrenous bowel. Recent mortality rates for MVT are lower than previously published, perhaps because of earlier diagnosis and aggressive treatment or possibly because we now readily diagnose a more benign form of the disease, which is due to widespread use of CT scanning. (+info)

Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study. (8/74)

BACKGROUND: Acquired antithrombin III (AT) deficiency may render heparin less effective during cardiac surgery and cardiopulmonary bypass (CPB). The authors examined the pharmacodynamics and optimal dose of recombinant human AT (rh-AT) needed to maintain normal AT activity during CPB, optimize the anticoagulant response to heparin, and attenuate excessive activation of the hemostatic system in patients undergoing coronary artery bypass grafting. METHODS: Thirty-six patients scheduled to undergo elective primary coronary artery bypass grafting and who had received heparin for 12 h or more before surgery were enrolled in the study. Ten cohorts of three patients each received rh-AT in doses of 10, 25, 50, 75, 100, 125, 175, or 200 U/kg, a cohort of six patients received 150 U/kg of rh-AT, and a control group of six patients received placebo. RESULTS: Antithrombin III activity exceeded 600 U/dl before CPB at the highest dose (200 U/kg). Doses of 75 U/kg rh-AT normalized AT activity to 100 U/dl during CPB. Activated clotting times during CPB were significantly (P < 0.0001) greater in patients who received rh-AT (844 +/- 191 s) compared with placebo patients (531 +/- 180 s). Significant (P = 0.001) inverse relations were observed between rh-AT dose and both fibrin monomer (r = -0.51) and D-dimer (r = -0.51) concentrations. No appreciable adverse events were observed with any rh-AT doses used in the study. CONCLUSIONS: Supplementation of native AT with transgenically produced protein (rh-AT) in cardiac surgical patients was well tolerated and resulted in higher activated clotting times during CPB and decreased levels of fibrin monomer and D-dimer. (+info)

PITX3 Antithrombin III deficiency; 613118; AT3 Antley-Bixler syndrome; 207410; FGFR2 Antley-Bixler syndrome-like with ... SDHAF1 Mitochondrial complex III deficiency; 124000; BCS1L Mitochondrial complex III deficiency; 124000; UQCRB Mitochondrial ... GATA1 Leukocyte adhesion deficiency; 116920; ITGB2 Leukocyte adhesion deficiency, type III; 612840; KIND3 Leukodystrophy, adult ... SDHD CPT deficiency, hepatic, type IA; 255120; CPT1A CPT deficiency, hepatic, type II; 600649; CPT2 CPT II deficiency, lethal ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... Levels of protein C, free and total protein S, factor VIII, antithrombin, plasminogen, tissue plasminogen activator (TPA) and ... a) Vascular thrombosis in three or more organs or tissues and. *b) Development of manifestations simultaneously or in less than ... and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti ...

https://en.wikipedia.org/wiki/Antiphospholipid_syndrome

Antithrombin III deficiency. altered coagulation. [14] Falls and hip fracture. related to immobility. [17] ... Three factors are important in the formation of a blood clot within a deep vein-these are the rate of blood flow, the thickness ... "Virchow's triad" has been suggested to describe the three factors necessary for the formation of thrombosis: stasis of blood, ... Protein C and/or S deficiency. congenital; associated with Warfarin necrosis. [14] ...

https://en.wikipedia.org/wiki/Thrombosis

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... doi:10.1016/s0140-6736(97)06356-3.. *^ Gando, S (1999). "Disseminated intravascular coagulation and sustained systemic ... Laboratory markers consistent with DIC include:[3][7][12] *Characteristic history (this is important because severe liver ... Treatment is mainly directed towards the underlying condition.[2][3] Other measures may include giving platelets, ...

https://en.wikipedia.org/wiki/Disseminated_intravascular_coagulation

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... Factor V deficiency Prolonged Prolonged Unaffected Unaffected Factor X deficiency as seen in amyloid purpura Prolonged ... Vitamin K deficiency or warfarin Prolonged Normal or mildly prolonged Unaffected Unaffected ... 3] There are several possible risks to treating coagulopathies, such as transfusion-related acute lung injury, acute ...

https://en.wikipedia.org/wiki/Coagulopathy

Kiehl R, Hellstern P, Wenzel E (January 1987). "Hereditary antithrombin III (AT III) deficiency and atypical localization of a ... including protein S deficiency, activated protein C resistance (Factor V Leiden) and antithrombin III deficiency. Although the ... These infants often have protein C deficiency as well. There have also been cases in patients with other deficiency, ... Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases the risk of ...

https://en.wikipedia.org/wiki/Warfarin_necrosis

antithrombin III. Inhibits IIa, Xa, and other proteases. Antithrombin III deficiency. heparin cofactor II. Inhibits IIa, ... The three main forms are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency or "Christmas disease") and ... AntithrombinEdit. Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases: thrombin, FIXa, FXa ... III (tissue factor or tissue thromboplastin ). Co-factor of VIIa (formerly known as factor III). ...

https://en.m.wikipedia.org/wiki/Coagulation

Acquired deficiencies in antithrombin III and C protein during treatment with L-asparaginase]. „Arch Fr Pediatr". 44 (3), s. ... Protein C Deficiency: eMedicine Hematology. [dostęp 2010-02-12]. *↑ F. Mielot, P. Danel, C. Boyer, L. Coulombel i inni. [ ... PROTEIN C DEFICIENCY, CONGENITAL THROMBOTIC DISEASE DUE TO w bazie Online Mendelian Inheritance in Man (ang.) ... Pregnancy and delivery in protein C-deficiency.. „Curr Drug Targets". 6 (5), s. 577-83, Aug 2005. PMID: 16026278. ...

https://pl.wikipedia.org/wiki/Białko_C

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... "Factor I deficiency (Fibrinogen deficiency) - Canadian Hemophilia Society". www.hemophilia.ca. Retrieved 2015-11-12.. ... Factor I Deficiency. References[edit]. *^ Neerman-Arbez, Marguerite; De Moerloose, Philippe (2007). "Mutations in the ... Gallastegui, N.; Kimble, E. L.; Harrington, T. J. (2015-09-01). "Resolution of fibrinogen deficiency in a patient with ...

https://en.wikipedia.org/wiki/Congenital_afibrinogenemia

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... quantitative deficiency).[10] Of those who have severe deficiency (defined as ,1% activity of factor VIII), 45-50% have the ... Haemophilia A (or hemophilia A) is a genetic deficiency in clotting factor VIII, which causes increased bleeding and usually ... Two of the most common differential diagnoses are haemophilia B which is a deficiency in Factor IX and von Willebrand Disease ...

https://en.wikipedia.org/wiki/Hemophilia_A

primary: Antithrombin III deficiency. *Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... Balgir RS (2012). "Community expansion and gene geography of sickle cell trait and G6PD deficiency, and natural selection ... 62 (3): 247-62. doi:10.1111/j.1574-695X.2011.00819.x. PMID 21585562.. Unknown parameter ,month=. ignored (tulong)CS1 maint: ... 3] Ang Sickle-cell anaemia ay isang anyo ng sakit na sickle-cell kung saan may homozygosity para sa mutasyon na nagsasanhi ng ...

https://tl.wikipedia.org/wiki/Sakit_na_sickle-cell

"Pulmonary arterial thrombosis in a neonate with homozygous deficiency of antithrombin III: successful outcome following ... "Pulmonary arterial thrombosis in a neonate with homozygous deficiency of antithrombin III: successful outcome following ... pulmonary thrombectomy and infusions of antithrombin III concentrate". His most cited article is the "Percutaneous pulmonary ... pulmonary thrombectomy and infusions of antithrombin III concentrate". Cardiology in the Young. 10 (3): 275-278. doi:10.1017/ ...

https://en.wikipedia.org/wiki/Reza_Razavi

The main ones are antithrombin III deficiency, protein C deficiency and protein S deficiency. Milder rare congenital ... antithrombin deficiency, was recognized in 1965 by the Norwegian hematologist Olav Egeberg. Protein C deficiency followed in ... Antithrombin deficiency is present in 0.2% of the general population and 0.5-7.5% of people with venous thrombosis. Protein C ... The first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, ...

https://en.wikipedia.org/wiki/Thrombophilia

... and antithrombin III and factor XII deficiency. The mechanism for the development of an SVT depends upon the specific etiology ... SVTs that occur within the great saphenous vein within 3 cm of the saphenofemoral junction are considered to be equivalent in ... Anticoagulation is also used for intermediate risk SVTs that are greater than 3 cm from the saphenofemoral junction or are ... Anticoagulation for high risk SVTs includes the use of vitamin K antagonists or novel oral anticoagulants (NOACs) for 3 months ...

https://en.wikipedia.org/wiki/Superficial_vein_thrombosis

Use in antithrombin III deficiency FFP can be used as a source of antithrombin III in patients who are deficient of this ... There are purified, human derived, as well as recombinant forms of antithrombin III available in the US. Treatment of ... Greater care should be taken in people with protein S deficiency, IgA deficiency, or heart failure. Fresh frozen plasma is made ... Single-donor plasma is efficacious in the treatment of mild deficiencies of stable clotting factors. It also is of value in ...

https://en.wikipedia.org/wiki/Fresh_frozen_plasma

... antithrombin III deficiency MeSH C16.320.099.080 - Bernard-Soulier syndrome MeSH C16.320.099.300 - factor V deficiency MeSH ... factor X deficiency MeSH C16.320.099.325 - factor XI deficiency MeSH C16.320.099.330 - factor XII deficiency MeSH C16.320. ... pyruvate dehydrogenase complex deficiency disease MeSH C16.320.565.240 - cytochrome-c oxidase deficiency MeSH C16.320.565.390 ... pyruvate carboxylase deficiency disease MeSH C16.320.565.150.750 - pyruvate dehydrogenase complex deficiency disease MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C16)

Ischemia Thrombotic diseases Degos disease Pseudoxanthoma elasticum Myeloproliferative disorders Antithrombin III deficiency ...

https://en.wikipedia.org/wiki/Multifocal_stenosing_ulceration_of_the_small_intestine

... proteins C and S deficiencies, and antithrombin III deficiency. Hypercoagulability in pregnancy, particularly due to ... However, the other major anticoagulants, protein C and antithrombin III, remain constant. Fibrinolysis is impaired by an ... Both anti-IIa and anti-Xa activity may return up to three hours after protamine reversal, possibly due to release of additional ... Pregnancy changes the plasma levels of many clotting factors, such as fibrinogen, which can rise up to three times its normal ...

https://en.wikipedia.org/wiki/Hypercoagulability_in_pregnancy

Acquired antithrombin deficiency occurs as a result of three distinctly different mechanisms. The first mechanism is increased ... Antithrombin is also termed Antithrombin III (AT III). The designations Antithrombin I through to Antithrombin IV originate in ... Antithrombin III (AT III) refers to a substance in plasma that inactivates thrombin. Antithrombin IV (AT IV) refers to an ... AT III is generally referred to solely as "Antithrombin" and it is Antithrombin III that is discussed in this article. ...

https://en.wikipedia.org/wiki/Antithrombin

... acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates". Intensive Care Med. 16 (2): 121 ... Acquired protein C deficiency is caused by either depletion of available protein C in plasma or decreased protein C synthesis ( ... Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S, International ... Regardless of the underlying cause of purpura fulminans, the mechanism of disease is similar with deficiency in protein C ...

https://en.wikipedia.org/wiki/Purpura_fulminans

... (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be ... Antithrombin Găman AM, Găman GD (2014). "Deficiency Of Antithrombin III (AT III) - Case Report and Review of the Literature". ... Testing for antithrombin activity can confirm deficiency if the levels are less than 70%. Deficiency can result from genetic ... The causes of acquired antithrombin deficiency are easier to find than the hereditary deficiency. The prevalence of ...

https://en.wikipedia.org/wiki/Antithrombin_III_deficiency

... antithrombin III, and protein C or S deficiency) are not absolute contraindications for hormonal therapy. A 2018 cohort study ... June 2002). "Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye". Annals of the New York Academy of ... The Endocrine Society recommends that patients have blood tests every three months in the first year of HRT for estradiol and ... Turo R, Jallad S, Prescott S, Cross WR (2013). "Metastatic prostate cancer in transsexual diagnosed after three decades of ...

https://en.wikipedia.org/wiki/Feminizing_hormone_therapy

... alopecia X linked Congenital amputation Congenital aneurysms of the great vessels Congenital antithrombin III deficiency ... II deficiency Carnitine transporter deficiency Carnitine-acylcarnitine translocase deficiency Carnosinase deficiency ... chain deficiency Complex 4 mitochondrial respiratory chain deficiency Complex 5 mitochondrial respiratory chain deficiency ... adrenal hyperplasia due to 11β-hydroxylase deficiency Congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

... disseminated intravascular coagulation and antithrombin deficiency (though this list is not exhaustive) There are three types ... "Protein S Deficiency. Learn about Protein S Deficiency , Patient". Patient. Retrieved 2016-10-16. "Protein S Deficiency: ... GG frameshift mutation in a family with mixed type I/type III protein S deficiency". Haematologica. 91 (8): 1151-2. PMID ... specifically 3q11.1 Protein S deficiency can also be acquired due to vitamin K deficiency, treatment with warfarin, liver ...

https://en.wikipedia.org/wiki/Protein_S_deficiency

Deficiencies in antithrombin, protein C, and protein S are rare but strong, or moderately strong, risk factors. These three ... Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factor V ... Genetic factors that increase the risk of VTE include deficiencies of three proteins that normally prevent blood from clotting- ... Three compression ultrasound scanning techniques can be used, with two of the three methods requiring a second ultrasound some ...

https://en.wikipedia.org/wiki/Deep_vein_thrombosis

Antithrombin III deficiency. *Protein C deficiency. *Activated protein C resistance. *Protein S deficiency ... For instance, deficiency of Factor VIII causes classic hemophilia A while deficiencies of Factor IX cause "Christmas disease"( ... Deficiencies of platelet function may require platelet transfusion while deficiencies of clotting factors may require ... Class III Hemorrhage involves loss of 30-40% of circulating blood volume. The patient's blood pressure drops, the heart rate ...

https://en.wikipedia.org/wiki/Haemorrhage

... and an increase in circulating antithrombin. Patients in the late stage had significant thrombocytopenia; deficiency of ... William III lost his mother to the disease when he was only ten years old in 1660, and named his uncle Charles as legal ... 978-3-642-76200-0. .. *^ a b c d e f g Fenner, F. (1988). "The History of Smallpox and its Spread Around the World" (PDF). ... If successful, a red and itchy bump develops at the vaccine site in three or four days. In the first week, the bump becomes a ...

https://en.m.wikipedia.org/wiki/Smallpox

... and anti-thrombin III, can manifest as iron-resistant microcytic anemia. Reference ranges[edit]. An example reference range for ... A high transferrin level may indicate an iron deficiency anemia. Levels of serum iron and total iron binding capacity (TIBC) ... III) binding sites. The affinity of transferrin for Fe(III) is extremely high (association constant is 1020 M−1 at pH 7.4)[7] ... The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains.[8] ...

https://en.wikipedia.org/wiki/Transferrin

Factor Xa is inhibited by the antithrombin III/heparin system, which also acts to inhibit thrombin. Deficiencies of either ... After the antithrombin III binds to Factor Xa, the Fondaparinux is released and can activate another antithrombin. Another drug ... Fondaparinux binds to antithrombin III and activates the molecule for Factor Xa inhibition. In fact, Fondaparinux imparts an ... Idraparinux also binds antithrombin III, however with a 30-fold increase in affinity as compared to Fondaparinux. Idraparinux ...

https://en.wikipedia.org/wiki/Prothrombinase

DeMeo DL, Silverman EK (March 2004). "Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: ... The three N-linked glycosylations sites are mainly equipped with so-called diantennary N-glycans. However, one particular site ... An extremely rare form of Pi, termed PiPittsburgh, functions as an antithrombin (a related serpin), due to a mutation ( ... All three products showed minor differences compared to the normal human plasma A1AT, and are introduced during the specific ...

https://en.wikipedia.org/wiki/Alpha-1_antitrypsin

Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ... Antithrombin (inhibits II, IX, X, XI, XII). *Protein C (inhibits V, VIII)/Protein S (cofactor for protein C) ... Tissue plasminogen activator (t-PA)[3] and urokinase are the agents that convert plasminogen to the active plasmin, thus ...

https://en.wikipedia.org/wiki/Fibrinolysis

Main article: Factor X deficiency. Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis ( ... This model has three stages: 1) initiation of coagulation on TF-bearing cells, 2) amplification of the procoagulant signal by ... antithrombin (AT) to inactivate several coagulation factors IIa, Xa, XIa and XIIa. The affinity of unfractionated heparin and ... Deficiency of vitamin K or antagonism by warfarin (or similar medication) leads to the production of an inactive factor X. In ...

https://en.wikipedia.org/wiki/Factor_X

... and an increase in circulating antithrombin. Patients in the late stage had significant thrombocytopenia, and deficiency of ... William III lost his mother to the disease when he was only ten years old in 1660, and she named his uncle Charles II as legal ... 978-3-642-76200-0. .. *^ a b c d e f g h Fenner, F. (1988). "The History of Smallpox and its Spread Around the World" (PDF). ... If successful, a red and itchy bump develops at the vaccine site in three or four days. In the first week, the bump becomes a ...

https://en.wikipedia.org/wiki/Smallpox

Within the first three hours of suspected sepsis, diagnostic studies should include white blood cell counts, measuring serum ... a deficiency of chemicals that constrict blood vessels such as vasopressin, and activation of ATP-sensitive potassium channels. ... the use of antithrombin to treat disseminated intravascular coagulation is also not useful. Meanwhile, the blood purification ... Within the first three hours, someone with sepsis should have received antibiotics and, intravenous fluids if there is evidence ...

https://en.wikipedia.org/wiki/Sepsis

Livingstone FB (1985). Frequencies of hemoglobin variants: thalassemia, the glucose-6-phosphate dehydrogenase deficiency, G6PD ... Of these, 93% reported being ill in the three weeks preceding the onset of Reye's syndrome, most commonly with a respiratory ... ISBN 978-3-527-32669-3.. *^ a b c d e f g h i j Jeffreys D (2008). Aspirin the remarkable story of a wonder drug. Bloomsbury ... Aspirin has been shown to have at least three additional modes of action. It uncouples oxidative phosphorylation in ...

https://en.wikipedia.org/wiki/Acetylsalicylic_acid

primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... adhesion (Bernard-Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky- ... Micro-: Iron deficiency anemia (Plummer-Vinson syndrome). Macro-: Megaloblastic anemia (Pernicious anemia) ...

https://bn.wikipedia.org/wiki/থ্যালাসেমিয়া

Heavy chains γ, α and δ have a constant region composed of three tandem (in a line) Ig domains, and a hinge region for added ... Some immune deficiencies, such as X-linked agammaglobulinemia and hypogammaglobulinemia, result in partial or complete lack of ... Basically, the antibody paratope is polygenic, made up of three genes, V, D, and J. Each paratope locus is also polymorphic, ... Differences, between the variable domains, are located on three loops known as hypervariable regions (HV-1, HV-2 and HV-3) or ...

https://en.wikipedia.org/wiki/Antibody

"Antithrombin III for critically ill patients: a systematic review with meta-analysis and trial sequential analysis". Intensive ... or after surgery or birthing in patients with hereditary antithrombin deficiency.[104][106] ... Antithrombin protein therapeuticsEdit. The antithrombin protein itself is used as a protein therapeutic that can be purified ... UFH binds to the enzyme inhibitor antithrombin III (AT), causing a conformational change that results in its activation.[83] ...

https://en.m.wikipedia.org/wiki/Anticoagulants

In addition, for the first three days of "warfarinization", the levels of protein C and protein S (anticoagulation factors) ... which occurs more frequently shortly after commencing treatment in patients with a deficiency of protein C. Protein C is an ... an anticoagulant that acts upon antithrombin and helps reduce the risk of thrombosis, with warfarin therapy for four to five ... Retrieved 3 April 2011.. *^ a b c Hirsh J, Fuster V, Ansell J, Halperin JL (May 2003). "American Heart Association/American ...

https://en.m.wikipedia.org/wiki/Warfarin

bind 抗凝血酶（英語：Antithrombin））. 低分子量肝素（貝米肝素（英語：Bemiparin sodium）、舍托肝素（英語：Certoparin sodium）、達肝素（英語：Dalteparin sodium）、依諾肝素、那屈肝素（英語 ... 維生素K缺乏症（英語：Vitamin K deficiency）或華法林. 延長. 正常或輕度延長. 無影響. 無影響. ... REG1（英語：REG1） · 去纖苷（英語：Defibrotide） · 雷馬曲班（英語：Ramatroban） · 抗凝血酶（英語：Antithrombin） ·

https://zh.wikipedia.org/zh-hant/阿斯匹林

Vitamin K deficiency. *Category:Vitamin K antagonists. References[edit]. .mw-parser-output .reflist{font-size:90%;margin-bottom ... Antithrombin III. *Defibrotide. *Protein C *Drotrecogin alfa‡. *Ramatroban. *REG1. Thrombolytic drugs/. fibrinolytics. * ... Another group of VKAs are 1,3-indandione derivatives. Pindone, chlorophacinone, and diphacinone are used as rodenticides. They ... for stroke or non-CNS embolism within 30 days after temporary interruptions of 3 days or more, early permanent study drug ...

https://en.wikipedia.org/wiki/Vitamin_K_antagonist

Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin ... and genetic or disease-related deficiencies in the blood's clotting abilities. ... Thrombi are classified in three major groups depending on the relative amount of platelets and red blood cells (RBCs).[3] The ...

https://en.m.wikipedia.org/wiki/Blood_clot

Antithrombin (inhibits II, IX, X, XI, XII). *Protein C (inhibits V, VIII)/Protein S (cofactor for protein C) ... see also cell surface receptor deficiencies. This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation ... "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ...

https://en.wikipedia.org/wiki/Integrin_beta_3

Antithrombin deficiency[6]. *Protein C deficiency[6]. *Protein S deficiency (type I)[18] ... 9 (49): iii-iv, ix-x, 1-78. doi:10.3310/hta9490. PMID 16336844.. ... The American College of Physicians (ACP) gave three strong ... The three factors of stasis, hypercoaguability, and alterations in the blood vessel wall represent Virchow's triad, and changes ... Trimester 3 513 29.2 (26.8-31.9) 340 19.4 (17.4-21.6) 103 18.2 (15.0-22.1) 355 19.7 (17.7-21.9) ...

https://en.wikipedia.org/wiki/Venous_thrombosis

Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin ... and genetic or disease-related deficiencies in the blood's clotting abilities. ... 3]*Common causes of stasis include anything that leads to prolonged immobility and reduced blood flow such as: trauma/broken ...

https://en.m.wikipedia.org/wiki/Blood_clots

Within the first three hours of suspected sepsis, diagnostic studies should include white blood cell counts, measuring serum ... Vasopressin can be used in septic shock because studies have shown that there is a relative deficiency of vasopressin when ... the use of antithrombin to treat disseminated intravascular coagulation is also not useful. Meanwhile, the blood purification ... Within the first three hours someone with sepsis should have received antibiotics and, intravenous fluids if there is evidence ...

https://hy.wikipedia.org/wiki/Մասնակից:ArmArtificial_Intelligence/Ավազարկղ

Deficiency of vitamin K or administration of the anticoagulant warfarin inhibits the production of gamma-carboxyglutamic acid ... In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels of ... Heparin increases the affinity of antithrombin to thrombin (as well as factor Xa). The direct thrombin inhibitors, a newer ... Thrombin is also inactivated by antithrombin, a serine protease inhibitor. The molecular weight of prothrombin is approximately ...

https://en.wikipedia.org/wiki/Thrombin

... comprises three homologous domains that assemble to form a heart-shaped protein.[2] Each domain is a product of two ... In some cases of retinol (Vitamin A) deficiency, the albumin level can be elevated to high-normal values (e.g., 4.9 g/dL). This ... For children less than three years of age, the normal range is broader, 2.9-5.5 g/dL.[9] ... evidence of a three-fold internal homology as in serum albumin and α-fetoprotein". Biochimica et Biophysica Acta (BBA) - ...

https://en.wikipedia.org/wiki/Albumins

https://en.m.wikipedia.org/wiki/Septicaemia

In three patients (#4, #5, #6) the disease progressed with a trend toward higher lymphocyte GSH levels. These results indicate ... Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Dröge, Wulf. Phil. Trans. R. Soc. B. Vol. 360, pp 2355- ... Body weight curves were similar in all three dietary groups. Hence, a whey protein diet appears to enhance the liver and heart ... The Use Of A Whey Protein Concentrate In The Treatment Of Patients With Metastatic Carcinoma : A Phase I-II Clinical Study ...

https://en.wikipedia.org/wiki/Lactalbumin

ആന്റിത്രോംബിൻ(antithrombin) III. IIa, Xa, മറ്റ് പ്രോട്ടിയേയ്സുകൾ എന്നിവയെ തടയുന്നു.. ആന്റിത്രോംബിൻ III യുടെ അഭാവം ... കൺജനൈറ്റൽ ഘടകം XIIIa/b അഭാവം (Congenital Factor XIIIa/b deficiency) വോൺ വിൽബ്രാൻഡ് ഘടകം(von Willebrand factor). ഘടകം VIII ... III ടിഷ്യൂ ഘടകം (Tissue factor). VIIa യുടെ കോഫാക്ടർ (factor III എന്ന് മുമ്പ് അറിയപ്പെട്ടിരുന്നത്). ... Prekallikrein/Fletcher Factor deficiency ഉയർന്ന തൻമാത്രാഭാരമുള്ള കൈനിനോജൻ (high-molecular-weight kininogen) (HMWK) (Fitzgerald ...

https://ml.wikipedia.org/wiki/രക്തം_കട്ടപിടിക്കൽ

It works by activating antithrombin III, which blocks thrombin from clotting blood. Heparin can be used in vivo (by injection ... or after surgery or birthing in patients with hereditary antithrombin deficiency.[25][27] ... Antithrombin protein therapeuticsEdit. The antithrombin protein itself is used as a protein therapeutic that can be purified ... "Thrombate III label" (PDF). Archived from the original (PDF) on 2012-11-15.. ...

https://en.m.wikipedia.org/wiki/Anticoagulant

Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be ... Antithrombin Găman AM, Găman GD (2014). "Deficiency Of Antithrombin III (AT III) - Case Report and Review of the Literature". ... Testing for antithrombin activity can confirm deficiency if the levels are less than 70%. Deficiency can result from genetic ... The causes of acquired antithrombin deficiency are easier to find than the hereditary deficiency. The prevalence of ...

https://en.wikipedia.org/wiki/Antithrombin_III_deficiency

Congenital antithrombin III deficiency is a genetic disorder that causes the blood to clot more than normal. ... The abnormal gene leads to a low level of the antithrombin III protein. This low level of antithrombin III can cause abnormal ... Congenital antithrombin III deficiency is an inherited disease. It occurs when a person receives one abnormal copy of the ... Congenital antithrombin III deficiency is a genetic disorder that causes the blood to clot more than normal. ...

https://medlineplus.gov/ency/article/000558.htm

In either case, treatment of the underlying disease and replacement of antithrombin III using antithrombin... more ... Acquired antithrombin III deficiency is due to decreased production or increased consumption. ... How is acquired antithrombin III (ATIII) deficiency treated?) and How is acquired antithrombin III (ATIII) deficiency treated? ... Drugs & Diseases , Pediatrics: General Medicine , Antithrombin III Deficiency Q&A How is acquired antithrombin III (ATIII) ...

https://www.medscape.com/answers/954688-119873/how-is-acquired-antithrombin-iii-atiii-deficiency-treated

Deficiency Of Antithrombin III (AT III) - Case Report and Review of the Literature. Curr Health Sci J. 2014 Apr-Jun. 40 (2):141 ... Drugs & Diseases , Pediatrics: General Medicine , Antithrombin III Deficiency Q&A What is the pathophysiology of antithrombin ... Two types of antithrombin III deficiency have been described. Type I (classic) is the result of decreased synthesis of ... Two functional assays for antithrombin III deficiency identified two separate subclasses of the type 2 defect. The assays are ...

https://www.medscape.com/answers/954688-119844/what-is-the-pathophysiology-of-antithrombin-iii-atiii-deficiency

Antithrombin III activity is markedly potentiated by heparin, the principle mechanism by which both heparin and low molecular ... Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by lysing thrombin and factor Xa. ... encoded search term (Antithrombin III Deficiency) and Antithrombin III Deficiency What to Read Next on Medscape. Related ... have heterozygous antithrombin III deficiency rather than the homozygous state.. Acquired antithrombin III deficiency is a ...

https://emedicine.medscape.com/article/954688-overview

primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden ... Differentiating Antithrombin III deficiency from other Diseases. Epidemiology and Demographics. Risk Factors. Screening. ... enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle- ... Retrieved from "https://www.wikidoc.org/index.php?title=Antithrombin_III_deficiency&oldid=1494831" ...

http://www.wikidoc.org/index.php/Antithrombin_III_deficiency

Antithrombin deficiency in three Japanese families: one novel and two reported point mutations in the antithrombin gene.. ... AT; Ala; Alanine; Antithrombin; Antithrombin deficiency; Arg; Arginine; Asp; Aspartic acid; CL; CM; COS-1 cells; Cell lysates; ... Inherited antithrombin (AT) deficiency is associated with a predisposition to familial venous thromboembolic disease. We ... We analyzed the SERPINC1 gene in three patients. Additionally, we expressed the three mutants in the COS-1 cells and compared ...

https://www.ncbi.nlm.nih.gov/pubmed/23809926?dopt=Citation

What is antithrombin-III deficiency? Meaning of antithrombin-III deficiency medical term. What does antithrombin-III deficiency ... Looking for online definition of antithrombin-III deficiency in the Medical Dictionary? antithrombin-III deficiency explanation ... antithrombin-III deficiency. Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia. antithrombin-III deficiency ... medical-dictionary.thefreedictionary.com/antithrombin-III+deficiency,antithrombin-III deficiency,/a,. *Facebook ...

https://medical-dictionary.thefreedictionary.com/antithrombin-III+deficiency

Antithrombin (AT III) Deficiency. Posted by Dr. Chris. What is antithrombin deficiency?. Antithrombin deficiency is a condition ... Types of Antithrombin Deficiency. There are two types of antithrombin deficiency - type I and type II. ... Causes of Antithrombin Deficiency. Antithrombin deficiency can be inherited or acquired. Inherited cases are usually present ... With type II antithrombin deficiency, the quantity of antithrombin is normal but it does not function as it should. The ...

https://www.healthhype.com/antithrombin-at-iii-deficiency.html

Congenital antithrombin III deficiency. Deficiency - antithrombin III - congenital; Antithrombin III deficiency - congenital ... Antithrombin III (AT III) is a protein that helps control blood clotting. A blood test can determine the amount of AT III ... The abnormal gene leads to a low level of the antithrombin III protein. This low level of antithrombin III can cause abnormal ... Congenital antithrombin III deficiency is an inherited disease. It occurs when a person receives one abnormal copy of the ...

https://www.stlukes-stl.com/health-content/health-ency-multimedia/1/000558.htm

Antithrombin Deficiency, type II) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, ... and treatment information for Antithrombin 3 Deficiency, type II ( ... Antithrombin Deficiency, type II: »Introduction: Antithrombin Deficiency, type II »Symptoms of Antithrombin Deficiency, type II ... Antithrombin Deficiency, type II »Symptoms of Antithrombin Deficiency, type II »Treatments for Antithrombin Deficiency, type II ...

https://www.rightdiagnosis.com/medical/antithrombin_3_deficiency_type_ii.htm

What is antithrombin III deficiency? Meaning of antithrombin III deficiency medical term. What does antithrombin III deficiency ... Looking for online definition of antithrombin III deficiency in the Medical Dictionary? antithrombin III deficiency explanation ... antithrombin III deficiency. Also found in: Wikipedia. antithrombin III deficiency. Congenital antithrombin III deficiency An ... See Antithrombin III. antithrombin III deficiency. An inherited deficiency of certain protein-splitting enzymes (proteases) ...

http://medical-dictionary.thefreedictionary.com/Antithrombin+III+deficiency

Among the causes, predisposing an individual to CTPV is natural anticoagulant protein C and antithrombin III deficiencies. ... We discuss a case of a nine-year-old male child diagnosed as CTPV secondary to protein C and antithrombin III deficiency who ... cavernous transformation, portal vein, portal hypertension, protein c deficiency, anti thrombin iii deficiency, pediatric, ... Cavernous Transformation of Portal Vein in the Setting of Protein C and Anti-thrombin III Deficiency Mahwish Nasim , Bushra ...

https://www.cureus.com/articles/23257-cavernous-transformation-of-portal-vein-in-the-setting-of-protein-c-and-anti-thrombin-iii-deficiency

He was found to be homozygous for the prothrombin G20210A mutation with mild deficiency for antithrombin III (AT III 73%, ... However, combinations of factor V Leiden and protein C deficiency, protein S deficiency or AT III deficiency greatly increase ... Concomitant homozygosity for the prothrombin gene variant with mild deficiency of antithrombin III in a patient with multiple ... with mildly reduced levels of anti-thrombin III (AT III). Subsequent testing of his father and brother revealed heterozygosity ...

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-4-122

Hereditary antithrombin deficiency is a disorder of blood clotting. Explore symptoms, inheritance, genetics of this condition. ... This gene provides instructions for producing a protein called antithrombin (previously known as antithrombin III). This ... medlineplus.gov/genetics/condition/hereditary-antithrombin-deficiency/ Hereditary antithrombin deficiency. ... Hereditary antithrombin deficiency is a disorder of blood clotting. People with this condition are at higher than average risk ...

https://medlineplus.gov/genetics/condition/hereditary-antithrombin-deficiency

hypercoagulable state/thrombophilia due to deficiency in antithrombin III. * *antithrombin III, an anticoagulant *inhibits ... MB BULLETS Step 2 & 3 For 3rd and 4th Year Med Students ... liver disease (antithrombin III is synthesized in the liver). * ... Male: 4.3-5.9 million/mm3. Female: 3.5-5.5 million mm3. ... Bicarbonate (HCO3-). 22-28 mEq/L. Magnesium (Mg2+). 1.5-2.0 mEq ...

https://step1.medbullets.com/hematology/109080/antithrombin-iii-deficiency

Genetics Home Reference related topics: Hereditary antithrombin deficiency Drug Information available for: Antithrombin III ... Experimental: Anti-thrombin III Drug: Anti-thrombin III Intraoperatively- (correcting to 100%) according to the following ... Antithrombin III Deficiency. Blood Coagulation Disorders, Inherited. Blood Coagulation Disorders. Hematologic Diseases. Blood ... Antithrombins. Antithrombin III. Hemostatics. Coagulants. Serine Proteinase Inhibitors. Protease Inhibitors. Enzyme Inhibitors ...

https://clinicaltrials.gov/ct2/show/NCT02103114?cond=%22antithrombin+deficiency%22&rank=5

The results indicate that antithrombin III-heparin cofactor activity is significantly lower... ... The antithrombin III-heparin cofactor activity of 65 baboons and 130 healthy human subjects was measured. ... Antithrombin III deficiency in a Dutch family.J. Clin. Path., 26: 532-538.PubMedGoogle Scholar ... Deficiency of antithrombin III activity associated with hereditary thrombosis tendency.J. Med., 3: 349-358.Google Scholar ...

https://link.springer.com/article/10.1007/BF02382805

THROMBATE III® (antithrombin III [human]) is indicated in patients with hereditary antithrombin deficiency for treatment and ... Because THROMBATE III is made from human blood, it may carry a risk of transmitting infectious agents, eg, viruses, the variant ... Please see full Prescribing Information for THROMBATE III.. You are encouraged to report negative side effects of prescription ... effect of heparin is enhanced by concurrent treatment with THROMBATE III in patients with hereditary AT deficiency. Thus, in ...

https://www.thrombate.com/en/venous-thromboembolism

Get natural cures for Congenital antithrombin III deficiency that can make a difference in your life or the life of someone you ... Congenital antithrombin III deficiency by state. Congenital antithrombin III deficiency in Alabama. Congenital antithrombin III ... Congenital antithrombin III deficiency in Hawaii. Congenital antithrombin III deficiency in Idaho. Congenital antithrombin III ... Congenital antithrombin III deficiency in Indiana. Congenital antithrombin III deficiency in Iowa. Congenital antithrombin III ...

http://www.naturalcurefor.com/treatments/congenital-antithrombin-iii-deficiency

Discover the top 25 questions that someone asks himself/herself when is diagnosed with Antithrombin III deficiency , ... Antithrombin III deficiency top 25 questions. Help others answering the top 25 questions of Antithrombin III deficiency. Become ... Antithrombin III deficiency diet. Is there a diet which improves the quality of life of people with Antithrombin III deficiency ... Living with Antithrombin III deficiency. How to live with Antithrombin III deficiency?. 2 answers. ...

https://www.diseasemaps.org/antithrombin-iii-deficiency/top-questions/

Secondary (symptomatic) deficiency of antithrombin III. Deep depression of the AT III level in plasma, creating or aggravating ... Treatment of Thrombophilia Associated with Antithrombin III Deficiency. 23.10.2020. Dr. Harry Shapiro Medicine ... Plasma doses depend on the clinical situation and the AT III deficiency. In case of massive thrombosis of the great vessels and ... If the patient has already received intensive heparin therapy, which is ineffective due to a deficiency of AT III, then its ...

https://treatment-diabetes-info.com/blog/2020/10/23/treatment-of-thrombophilia-associated-with-antithrombin-iii-deficiency/

Helping you find trustworthy answers on Factor IX Deficiency , Latest evidence made easy ... Find all the evidence you need on Factor IX Deficiency via the Trip Database. ... Antithrombin III-deficient patients (...) . Previous References Gaman AM, Gaman GD. Deficiency Of Antithrombin III (AT III) - ... Antithrombin III Deficiency (Treatment) of vitamin K-dependent procoagulant factors (II, VII, IX, X) is reduced adequately for ...

https://www.tripdatabase.com/search?criteria=Factor+IX+Deficiency&page=5

Thrombophilia Due to Acquired Antithrombin III Deficiency. Intervention: Drug: Recombinant antithrombin (rhAT). ... Recombinant Antithrombin (rhAT). Subjects will receive an intravenous bolus of 500 units of recombinant, human antithrombin ( ... Recombinant Antithrombin (rhAT). Subjects will receive an intravenous bolus of 500 units of recombinant, human antithrombin ( ... Response of Recombinant Antithrombin in Heparin Resistant Patients Undergoing Cardiac Surgery. The safety and scientific ...

https://clinicaltrials.gov/ct2/show/results/NCT01547728

Abcams Antithrombin III ELISA Kit suitable for Cell culture supernatant, Saliva, Milk, Urine, Serum, Plasma, Cell culture ... An antithrombin III specific antibody has been precoated onto 96-well plates and blocked. Standards or test samples are added ... Abcams Antithrombin III Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative ... Antithrombin III in human biological fluids (duplicates +/- SD). The samples were differently diluted (serum and Li-heparine ...

http://www.abcam.com/human-antithrombin-iii-elisa-kit-ab108801.html

... immunoassay suitable for the quantification of Antithrombin III in Cell culture supernatant, Urine, Serum, Plasma samples. ... Mouse Antithrombin III ELISA Kit (SERPINC1) is a sensitive (3 ng/ml) ... An Antithrombin III specific antibody has been precoated onto 96-well plates and blocked. Standards or test samples are added ... Abcams Antithrombin III (SERPINC1) Mouse in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the ...

https://www.abcam.com/Mouse-Antithrombin-III-ELISA-Kit-SERPINC1-ab108800.html?utm_source=biocompare&

Antithrombin III activity was estimated by a chromogenic assay. Hence, antithrombin III deficiency, though rare, should be ... A deficiency of plasma antithrombin III has been identified as a potential risk factor for thrombosis. In a pilot study of 56 ... Nagaraja D, Christopher R, Tripathi M. Plasma antithrombin III deficiency in ischaemic stroke in the young. Neurology India. ... we detected only one case of plasma antithrombin III deficiency. ... Plasma antithrombin III deficiency in ischaemic stroke in the ...

https://imsear.searo.who.int/handle/123456789/120085

Antithrombin III replacement in animal models of acquired antithrombin III deficiency. Emerson, T. E. Jr ... Acquired antithrombin III deficiency-rationale for replacement therapy. Introduction and overview-What are the questions?. ... Acquired antithrombin III deficiency secondary to asparaginase therapy in childhood acute lymphoblastic leukaemia. Andrew, M.; ... Panel Discussion: Rationale for replacement therapy for acquired antithrombin III deficiency. Blajchman, Morris A. ...

https://journals.lww.com/bloodcoagulation/toc/1994/01000

https://en.wikipedia.org/wiki/Antiphospholipid_syndrome

https://en.wikipedia.org/wiki/Coagulopathy

Congenital antithrombin III deficiency is a genetic disorder that causes the blood to clot more than normal. (medlineplus.gov)
Congenital antithrombin III deficiency is an inherited disease. (medlineplus.gov)
Congenital antithrombin deficiency in patients with splanchnic vein thrombosis. (medscape.com)
Congenital antithrombin III deficiency is an autosomal dominant disorder in which an individual inherits one copy of the SERPINC1 (also called AT3 ) gene on chromosome 1q25.1, which encodes antithrombin III. (medscape.com)
Severe congenital antithrombin III deficiency, in which the individual inherits two defective genes, is a rare autosomal recessive condition associated with increased thrombogenesis, typically noted in the neonatal period or early infancy. (medscape.com)
Once a patient with congenital antithrombin III deficiency has developed thrombosis, anticoagulation is more strongly indicated. (medscape.com)
Congenital antithrombin III deficiency An AD condition characterized by ↑ risk of DVT and PE. (thefreedictionary.com)
The new product, which is a human antithrombin III concentrate, is indicated for the treatment of thrombosis associated with congenital antithrombin III deficiency as well as disseminated intravascular coagulation. (thefreedictionary.com)
Congenital antithrombin III deficiency is defined as the lack of the potent inhibitor for the coagulation cascade. (naturalcurefor.com)
For severe congenital antithrombin III deficiency, the neonate has inherited 2 types of defective genes and is often easily noted during infancy stage. (naturalcurefor.com)
Protein C tests, ATIII measurements, as well as protein S deficiencies are among the primary medical tests conducted for infants with congenital antithrombin III deficiency. (naturalcurefor.com)
Treatment of patients suffering from congenital antithrombin III deficiency depends would largely depend on the clinical setting. (naturalcurefor.com)
There are no physical symptoms that can be associated to congenital antithrombin III deficiency. (naturalcurefor.com)
Congenital protein C or S deficiency is a lack of proteins C or S in the fluid part of the blood. (stlukes-stl.com)
J. Conard, Congenital AT III deficiency. (springer.com)
No case of congenital antithrombin-III deficiency was identified. (uptodate.com)
A Case of Congenital Antithrombin III Deficiency Asociated with Extrahepatic Portal Occlusion and Esophgo-Gastric Varices. (nii.ac.jp)
We studied three thrombofilic families with congenital antithrombin deficiency. (mapfre.com)

Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. (medscape.com)
Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. (medscape.com)
Hereditary antithrombin deficiency results in a state of increased coagulation which may lead to venous thrombosis. (wikipedia.org)
There is an elevated risk of thrombosis, whereby 50% patients with AT deficiency were found to have venous thromboembolism by age 50. (wikipedia.org)
childhood thrombosis, 3. (wikipedia.org)
Deficiency can result from genetic predisposition or from acquired causes such as: acute thrombosis, disseminated intravascular coagulopathy, liver disease, nephrotic syndrome, asparaginase deficiency, oral contraception/estrogens. (wikipedia.org)
We analyzed the AT gene in three unrelated patients with an AT deficiency who developed thrombosis. (nih.gov)
The symptoms seen in antithrombin deficiency largely depends on the site of clot formation (thrombosis). (healthhype.com)
It is usually secondary to long-standing portal vein thrombosis (PVT) that causes portal hypertension and occlusion of the portal vein, consequently leading to the development of multiple small dilated blood vessels in and around the native portal vein [2-3] . (cureus.com)
We report a case of a nine-year-old male child diagnosed as CPTV secondary to protein C and antithrombin III deficiency who presented with generalized weakness, pancytopenia, portal vein thrombosis, splenomegaly, and perisplenic and splenorenal varices. (cureus.com)
For neonates with homozygote deficiency, both the venous and arterial thrombosis is examined, principally if treatment involves vascularly invasive procedures such as umbilical vessel catheterization and extracorporeal membrane oxygenation. (naturalcurefor.com)
In case of massive thrombosis of the great vessels and life-threatening embolic complications, 800-1200 ml of plasma is administered in 2-3 doses on the first day, and then 400 ml daily. (treatment-diabetes-info.com)
The level of AT III in the plasma decreases in the same manner in case of massive thrombosis and thromboembolism, which in the acute period makes it difficult to differentiate between primary (genetically determined) thrombophilia and secondary depression of AT III. (treatment-diabetes-info.com)
A significant decrease in the plasma AT III, accompanied by a predisposition to thrombosis, is observed in nephrotic syndrome, severe liver disease and some malignant neoplasms. (treatment-diabetes-info.com)
A deficiency of plasma antithrombin III has been identified as a potential risk factor for thrombosis. (who.int)
The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β 2 -glycoprotein-I (since β 2 -glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
Under normal conditions, antithrombin III (AT III), protein C, and protein S as an active protein C cofactor, are natural anticoagulants (hemostatic control) that balances procoagulant activity (thrombin antithrombin complex balance) to prevent thrombosis. (ui.ac.id)
All forms of AT deficiency increase the risk for venous thrombosis and, far less commonly, arterial thrombosis. (medscape.com)
Thus, even short periods of abnormal liver function may reduce antithrombin production, leading to potential thrombosis. (medscape.com)
We present a case of a pregnant woman with hereditary antithrombin III deficiency and deep vein thrombosis of the left lower extremity managed by perinatal unfractionated heparin injection with antithrombin III replacement as well as by intrapartum placement of a temporary inferior vena cava filter. (elsevier.com)
Hereditary antithrombin III deficiency increases risk of thrombosis during pregnancy. (elsevier.com)
Our experience suggests that thrombosis can occur and develop during the intrapartum period in an antithrombin III deficient woman despite antithrombin III replacement. (elsevier.com)
Primary venous thrombosis caused by deficiency or qualitative abnormality of antithrombin III , protein C and protein S is usually inherited as an autosomal dominant trait. (bvsalud.org)
Less than 70% of the normal value increases the risk of venous thrombosis because of the role of antithrombin in the inactivation of thrombin, factors VIIa, IXa, Xa, XIa, kallikrein and plasma. (brainscape.com)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. (sigmaaldrich.com)
Our study opens new perspectives in the search of new genetic defects involved in antithrombin deficiency and the risk of thrombosis as well as in the design of new antithrombotic treatments. (sigmaaldrich.com)
J.R. O'Brien, Antithrombin III and heparin clotting times in thrombosis and atherosclerosis. (springer.com)
three of these 10 patients had portal vein thrombosis. (uptodate.com)
Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. (wikipedia.org)
2 3 4 5 6 Recently, a poor anticoagulant response to activated PC has been described in patients with inherited thrombophilia and is as yet the most common inherited risk factor for thrombosis known (20% to 40% prevalence among patients with venous thrombosis). (ahajournals.org)
Thromboembolism (prophylaxis and/or treatment)-Anticoagulants are indicated for prophylaxis and/or treatment of venous [or arterial] thrombosis (and its extension) and pulmonary embolism {05}3 {05}2 {05}1 {05}0 {03}9 {03}8 {03}7 {03}6 {03}5 . (drugs.com)
Circulating microparticles and the risk of thrombosis in inherited deficiencies of antithrombin, protein C and protein S. (semanticscholar.org)
Type I AT deficiency is the most common inherited form among patients with thrombosis (60% of all patients with thrombosis and AT deficiency), while type II deficiency is the most common form in the general population (88% of all members of the general public identified as having AT deficiency). (oncologynurseadvisor.com)
Acquired causes of antithrombin deficiency include acute thrombosis, disseminated intravascular coagulation (DIC), heparin therapy, nephrotic syndrome, L-asparaginase therapy, and liver disease. (oncologynurseadvisor.com)
Acquired protein C deficiency can result from vitamin K deficiency, vitamin K antagonist (for example, warfarin) therapy, acute thrombosis, DIC, or liver disease. (oncologynurseadvisor.com)
Since, in 1965 Egeber described the first antithrombin deficiency associated with an increase of thrombotic risk, many studies have identified families with antithrombin deficiency that caused a significantly increase in the risk of venous thrombosis. (mapfre.com)
We confirmed that antithrombin Cambridge II is not restricted to British population, as we observed this mutation in 0.2% of Spanish population and in 1.7% of patients with venous thrombosis. (mapfre.com)
Moreover, this mutation was the main cause of antithrombin deficiency among patients with venous thrombosis. (mapfre.com)

Rosenberg RD. Actions and interactions of antithrombin and heparin. (medscape.com)
In patients with antithrombin deficiency, they may develop resistance to unfractionated heparin, especially with continuous infusions. (wikipedia.org)
Antithrombin concentrates have been used, though with risk of bleeding at large doses of unfractionated heparin. (wikipedia.org)
The assays are the antithrombin-heparin cofactor activity and the progressive antithrombin activity. (medscape.com)
The first measures the ability of heparin to neutralize the enzymatic activity of thrombin and factor Xa and the second measures the ability of antithrombin III to neutralize thrombin in the absence of heparin. (medscape.com)
Heterozygotes of type 2 antithrombin III deficiency that exhibit diminished levels of both thrombin-heparin cofactor and progressive antithrombin activity level usually carry a mutation near the thrombin binding site (active site), while those with diminished thrombin-heparin cofactor and normal progressive antithrombin activity are carriers of a defect in the heparin binding site. (medscape.com)
Antithrombin III activity is markedly potentiated by heparin, the principal mechanism by which both heparin and low-molecular-weight heparin result in anticoagulation. (medscape.com)
Oral contraceptive use and even heparin administration have also been associated with antithrombin III deficiency. (medscape.com)
Antithrombin is not extremely efficient and becomes more potent when it works synergistically with heparin, another natural anticoagulant. (healthhype.com)
Women with this deficiency are at serious risk of developing THROMBOEMBOLISM in pregnancy and HEPARIN treatment is necessary. (thefreedictionary.com)
Data reported as % Functional Activity, which is calculated as the ability of Antithrombin (AT) to suppress FIIa or FXa in the presence of heparin compared to normograms, and expressed as a percentage. (clinicaltrials.gov)
If the patient has already received intensive heparin therapy, which is ineffective due to a deficiency of AT III, then its administration with plasma can immediately cause deep hypocoagulation and even hemorrhagic complications. (treatment-diabetes-info.com)
To avoid such an "overdose", hematological preparations containing AT III are administered no earlier than 2-3 hours after the last injection of heparin. (treatment-diabetes-info.com)
In case of milder thrombophilia, a pronounced therapeutic effect is achieved even with small doses of lyophilized plasma (200 ml every 1-2 days) in combination with the subcutaneous injection of small doses of heparin into the anterior abdominal wall (5000 IU 3-4 times a day). (treatment-diabetes-info.com)
The use of heparin without plasma is ineffective and can aggravate AT III deficiency. (treatment-diabetes-info.com)
The antithrombin III-heparin cofactor activity of 65 baboons and 130 healthy human subjects was measured. (springer.com)
The results indicate that antithrombin III-heparin cofactor activity is significantly lower in baboons than in humans. (springer.com)
The increased activity of the coagulation system of baboon is coupled with decreased antithrombin III-heparin cofactor activity. (springer.com)
Antithrombin III, antifactor Xa and Heparin. (springer.com)
When patients with a known inherited AT deficiency who are experiencing an acute thrombotic event fail to respond to intravenous heparin, treatment with a direct thrombin inhibitor (eg, argatroban, dabigatran) is recommended. (medscape.com)
Antithrombin belongs to the serpin family of inhibitors, which include heparin cofactor II (HCII), alpha2-antiplasmin, plasminogen activator inhibitor-1 (PAI-1), C1-inhibitor, and alpha1-antitrypsin. (medscape.com)
O.R. Odegard, M.K. Fagerhol, M. Lie, Heparin cofactor activity and antithrombin III concentration in plasma related to age and sex. (springer.com)
Treatment of coagulopathy was by heparin in three patients and sodium warfarin (Coumadin) in four patients. (uptodate.com)
See also individual Antithrombin III (Systemic) , Ardeparin (Systemic) , Dalteparin (Systemic) , Danaparoid (Systemic) , Enoxaparin (Systemic) , and Heparin (Systemic) monographs. (drugs.com)
Oral anticoagulants are used during and following initial heparin therapy {03}4 {03}3 {03}2 to decrease the risk of extension, recurrence, or death. (drugs.com)
3. How does heparin anticoagulate? (anaesthesiauk.com)
Heparin binds to antithrombin III and the activated forms of factors II, X, XI, XII, and XIII, having an anticoagulant effect of about ninety minutes. (anaesthesiauk.com)
Treatment in 13 patients consisted of unfractionated intravenous heparin followed by three to six months of warfarin therapy. (aafp.org)
Common names and abbreviations for the same protein are antithrombin, antithrombin III, AT, ATIII, and heparin cofactor I. (stoptheclot.org)
If antithrombin levels are measured at the time of an acute clot or while the patient is on heparin, levels may be temporarily low. (stoptheclot.org)
Type II AT deficiency can be caused by mutations in the active site (so-called Type IIa AT deficiency, which is rarer but associated with a greater risk of VTE) and mutations in the heparin binding site (so-called Type IIb AT deficiency, which is more common and is associated with smaller increase in VTE risk). (oncologynurseadvisor.com)

Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by neutralizing the enzymatic activity of thrombin (factors IIa, IXa, Xa). (medscape.com)
Despite its name, antithrombin does not only inhibit thrombin. (healthhype.com)
A thrombophilia screen confirmed a homozygous mutation for the prothrombin gene mutation, with mildly reduced levels of anti-thrombin III (AT III). (biomedcentral.com)
Inherited thrombophilia can be due to inactive variants of endogenous anticoagulants (protein C, S and anti-thrombin III). (biomedcentral.com)
Antithrombin blocks the activity of proteins that promote blood clotting, especially a protein called thrombin. (medlineplus.gov)
Thrombin inhibitory activity of fractions obtained by gel filtration of Antithrombin III deficient plasma. (springer.com)
Comparison of progressive antithrombin activity and the concentrations of three thrombin inhibitors in human plasma. (springer.com)
AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. (abcam.com)
Functional assays assessing inhibitory activity on Xa have a higher sensitivity than those assessing thrombin and some patients with Type II antithrombin deficiency have only slightly reduced or even normal function, thus increasing the complexity of its diagnosis. (medscape.com)
Paul Morawitz at the University of Tubingen first coined the term antithrombin in 1905 to describe plasma's ability to neutralize thrombin activity. (medscape.com)
As its name implies, antithrombin was first characterized as an inhibitor of thrombin. (medscape.com)
At presentation, plasma concentrations of three of four markers of in vivo thrombin activity (TAT, F1.2, APCAT, but not APC-PCI) were increased in children with ALL. (ashpublications.org)
In 1965 anti-thrombin deficiency was identified as the genetic cause of thrombophilia. (intechopen.com)
The physiological target proteases of antithrombin are those of the intrinsic coagulation system , namely the activated forms of Factor X (Xa), Factor IX (IXa), Factor VII (VIIa), Factor XI (XIa), Factor XII (XIIa) and Factor II (thrombin) (IIa). (bionity.com)
The four DOACs, including the three factor Xa inhibitors ( apixaban , edoxaban , and rivaroxaban ) and one direct thrombin inhibitor ( dabigatran ) provide oral anticoagulation therapy alternatives to vitamin K antagonist ( VKA ) therapy. (apsfa.org)
Antithrombin (AT) binds and inactivates activated serine proteases such as factor Xa and factor IIa (thrombin). (oncologynurseadvisor.com)

How is acquired antithrombin III (ATIII) deficiency treated? (medscape.com)
Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. (wikipedia.org)
What is the pathophysiology of antithrombin III (ATIII) deficiency? (medscape.com)
There are actually two different types of ATIII Deficiency that may be largely due to a number of varying genetic defects that can be directly with associated with conflicting levels of enzymatic activity, enzyme production and chemical stability. (naturalcurefor.com)

Role of antithrombin concentrate in treatment of hereditary antithrombin deficiency. (medscape.com)
This agent is indicated for patients with hereditary antithrombin III deficiency or thromboembolism and is rated pregnancy risk category B. (thefreedictionary.com)
Hereditary antithrombin deficiency is a disorder of blood clotting. (medlineplus.gov)
In hereditary antithrombin deficiency, abnormal blood clots usually form only in veins, although they may rarely occur in arteries. (medlineplus.gov)
About half of people with hereditary antithrombin deficiency will develop at least one abnormal blood clot during their lifetime. (medlineplus.gov)
Other factors can increase the risk of abnormal blood clots in people with hereditary antithrombin deficiency. (medlineplus.gov)
The combination of hereditary antithrombin deficiency and other inherited disorders of blood clotting can also influence risk. (medlineplus.gov)
Women with hereditary antithrombin deficiency are at increased risk of developing an abnormal blood clot during pregnancy or soon after delivery. (medlineplus.gov)
Hereditary antithrombin deficiency is estimated to occur in about 1 in 2,000 to 3,000 individuals. (medlineplus.gov)
Of people who have experienced an abnormal blood clot, about 1 in 20 to 200 have hereditary antithrombin deficiency. (medlineplus.gov)
Hereditary antithrombin deficiency is caused by mutations in the SERPINC1 gene. (medlineplus.gov)
Most of the mutations that cause hereditary antithrombin deficiency change single protein building blocks (amino acids) in antithrombin, which disrupts its ability to control blood clotting. (medlineplus.gov)
THROMBATE III ® (antithrombin III [human]) is indicated in patients with hereditary antithrombin deficiency for treatment and prevention of thromboembolism and for prevention of perioperative and peripartum thromboembolism. (thrombate.com)
Issues in the Diagnosis and Management of Hereditary Antithrombin Deficiency. (semanticscholar.org)

The main method of pathogenetic therapy and prevention of thromboembolism in thrombophilia is AT III replacement. (treatment-diabetes-info.com)
1 It has been known for several decades that deficiencies of the natural coagulation inhibitors, such as antithrombin (AT), protein C (PC), and protein S (PS), are associated with inherited thrombophilia. (ahajournals.org)
To date, only 1 clinical study on unselected cases of VTE (Leiden Thrombophilia Study) 8 10 is available comparing directly APCR and the other coagulation inhibitor deficiencies. (ahajournals.org)
1 In 1965 the first family with antithrombin deficiency was described, and for many years this was the only identifiable cause of thrombophilia. (bmj.com)

Antithrombin III is an anticoagulant. (healthhype.com)
A hypercoagulable workup that included lupus anticoagulant, factor V Leiden, prothrombin G20210A mutation, homocysteine, protein C and S deficiency, and antithrombin III deficiency were negative. (thefreedictionary.com)
Among the causes, predisposing an individual to CTPV is natural anticoagulant protein C and antithrombin III deficiencies. (cureus.com)
Deep depression of the AT III level in plasma, creating or aggravating the thrombogenic hazard, is more often associated with the intensive consumption (consumption) of this anticoagulant to inactivate blood coagulation factors. (treatment-diabetes-info.com)
Risk factor assessment after diagnosis included obtaining a detailed history and laboratory tests for protein C antigen, protein S antigen and activity, activated protein C resistance (APCR), antithrombin III activity, lupus anticoagulant and anticardiolipin antibodies (aCL-Abs). (aafp.org)
1 Therefore the finding of a low level of a natural anticoagulant on a single occasion is not diagnostic of primary deficiency of a natural anticoagulant. (bmj.com)
Antithrombin is the most important haemostatic anticoagulant. (mapfre.com)

Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism. (medscape.com)
It's important to routinely search for these abnormalities as well as for the other leading inherited thrombophilias--factor V Leiden mutation, prothrombin gene mutations, antithrombin III deficiency , protein S deficiency and protein C deficiency--in all women with a history of venous thromboembolism who are pregnant or planning pregnancy. (thefreedictionary.com)
The more common qualitative Type II is characterized by normal antithrombin levels and reduced function and is further categorised into IIa, b, or c, depending on which part of the antithrombin molecule is affected by the mutation. (medscape.com)
There are 2 major causes of AT deficiency: (a) an inherited deficiency due to a genetic abnormality (mutation), and (b) an acquired deficiency due to some other disease (see table, numbers 1-3). (stoptheclot.org)
The risk of spontaneous or risk-period related venous thromboembolism in family members of symptomatic carriers of antithrombin (AT), protein C (PC) or protein S (PS) defects, as well as of the Factor V Leiden mutation is still undefined. (semanticscholar.org)
Conversely, a single normal result does not exclude a mutation affecting the antithrombin, protein C, or protein S genes. (bmj.com)
Women with this mutation have nearly 3 times the normal risk of suffering a DVT or PE. (simstat.com)

Two types of antithrombin III deficiency have been described. (medscape.com)

It occurs when a person receives one abnormal copy of the antithrombin III gene from a parent with the disease. (medlineplus.gov)
The abnormal gene leads to a low level of the antithrombin III protein. (medlineplus.gov)
Antithrombin deficiency in three Japanese families: one novel and two reported point mutations in the antithrombin gene. (nih.gov)
We analyzed the SERPINC1 gene in three patients. (nih.gov)
We describe the case of a 42-year-old man who presented with abdominal pain attributed to multiple hepatic infarctions who had a combination of homozygosity for the prothrombin gene variant and mild deficiency of antithrombin III (AT III). (biomedcentral.com)
This gene provides instructions for producing a protein called antithrombin (previously known as antithrombin III). (medlineplus.gov)
This type of deficiency is categorized as an autosomal dominant disorder that an infant can inherit through a copy of a defective gene. (naturalcurefor.com)
Quantitative antithrombin deficiency Type I results from heterozygous point mutations or major gene deletions leading to low antithrombin antigen and activity levels. (medscape.com)
Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the promoter, intron 1 and 2 of this gene in 23 patients with antithrombin deficiency but without known genetic defects. (sigmaaldrich.com)
There are many different mutations in the antithrombin gene that can lead to inherited AT deficiency. (stoptheclot.org)
In two of them, we identified mutations in antithrombin gene not described previously: InsT7429-30 and Lys125Arg. (mapfre.com)

Even just half the normal antithrombin levels are sufficient to lead to abnormal clotting. (healthhype.com)

Antithrombin III (henceforth referred to as antithrombin or AT) is a 58-kDa molecule belonging to the serine protease inhibitor (serpin) superfamily that plays a central role in anticoagulation and in regulating appropriate wound healing in mammalian circulation systems. (medscape.com)
Long-term anticoagulation was not instituted because of gastrointestinal bleeding in three and cirrhosis in three patients. (uptodate.com)

It is due to absent or deficient levels of antithrombin III in the blood. (thefreedictionary.com)
However, elevated levels of antithrombin do not appear to cause bleeding or have any clinical significance. (stoptheclot.org)

IMSEAR at SEARO: Plasma antithrombin III deficiency in ischaemic stroke in the young. (who.int)
Nagaraja D, Christopher R, Tripathi M. Plasma antithrombin III deficiency in ischaemic stroke in the young. (who.int)
In a pilot study of 56 patients aged less than 40 years who presented with ischaemic stroke of unknown etiology, we detected only one case of plasma antithrombin III deficiency. (who.int)
One genetic defect, c.42-1060_-1057dupTTGA, was a new low prevalent polymorphism (MAF: 0.01) with functional consequences on plasma antithrombin levels. (sigmaaldrich.com)
H.W. Pratt, Alterations in plasma antithrombin III activity in patients with myocardial infarction. (springer.com)
R.H. Yue, M.M. Gertler, T. Staar, R. Koutrouby, Alteration of plasma antithrombin III levels in ischemic heart disease. (springer.com)
H. Stormorken, J. Erikssen, Plasma antithrombin III and factor VIII antigen in relation to angiographic findings, angina and blood groups in middle-aged men. (springer.com)

In 1965, Olav Egeberg described the first family with thrombotic disease due to inherited antithrombin deficiency, providing convincing evidence of the clinical importance of antithrombin. (medscape.com)

Assay of progressive antithrombin in plasma. (springer.com)
Antithrombin III activity was estimated by a chromogenic assay. (who.int)
Abcam's Antithrombin III Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Antithrombin III in urine, plasma, milk, saliva, cerebrospinal fluid, serum, and cell culture supernatants. (abcam.com)
Antithrombin functional assay is the preferred initial diagnostic study, in order not to miss Type II deficiency. (medscape.com)

Thirty subjects with acute coronary syndrome (ACS) were studied for the incidence of antithrombin III (AT III), protein C, and protein S deficiencies, and the result were compare to the control group. (ui.ac.id)

AT deficiency seems to have a higher risk for VTE than the other genetic defects. (ahajournals.org)
Alpha-1 Antitrypsin Deficiency - Genetic deficiency which may result in life-threatening lung disease in adults and/or liver disease in people of any age. (pptaglobal.org)
Haemophilia A (or hemophilia A ) is a genetic deficiency in clotting factor VIII , which causes increased bleeding and usually affects males. (wikipedia.org)
The highest relative risk is associated with mutations affecting the functional plasma levels of the natural anticoagulants antithrombin, protein C, and protein S. In these cases the extent of possible mutations excludes routine genetic testing. (bmj.com)

Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency. (sigmaaldrich.com)
Three cases with moderate antithrombin deficiency (63-78%) carried potential regulatory mutations. (sigmaaldrich.com)
Antithrombin deficiency can result from mutations that affect protein production (type I AT [antithrombin] deficiency) or synthesis of a dysfunctional protein (type II AT deficiency). (oncologynurseadvisor.com)
These reactions are accelerated in the presence of free protein S. Mutations that reduce protein synthesis (type 1 protein C deficiency) or result in the production of a dysfunctional protein C (type 2 protein C deficiency) have been identified. (oncologynurseadvisor.com)

Differential diagnosis of DIC included microangiopathic pathologies like infectious reasons (purpura fulminans), soft tissue injury due to trauma, snake or insect venom, severe thrombotic, thrombocytopenic purpura and hemolytic uremic syndrome and hereditary thrombotic abnormalities like antithrombin III deficiency , and heterozygous PC and PS deficiency. (thefreedictionary.com)
This is important to know to avoid a wrong diagnosis of "AT deficiency" if low values are found. (stoptheclot.org)
A definitive diagnosis of hereditary deficiency is sometimes difficult to make because of these interfering causes. (stoptheclot.org)
Sometimes, family testing is necessary to help clarify the diagnosis of inherited versus acquired deficiency. (stoptheclot.org)
Practical advice for any patient who carries the diagnosis of "AT deficiency" is to question the diagnosis and make sure the diagnosis was not based on a low level obtained at the time of an acute clot. (stoptheclot.org)

[4] As deduced from protein and cDNA sequencing, cow, sheep, rabbit and mouse antithrombins are all 433 amino acids in length, which is one amino acid longer than human antithrombin III. (bionity.com)
All these sites are occupied by covalently attached oligosaccharide side chains in the predominant form of human antithrombin, α-antithrombin. (bionity.com)
In human antithrombin this bond is between arginine (arg) 393 and serine (ser) 394. (bionity.com)

However, the presence of anticoagulants like antithrombin ensures that the activated clotting enzymes do not create clots at various sites in the circulation. (healthhype.com)
Natural anticoagulants, namely protein C and antithrombin III deficiencies, are among the common hereditary thrombophilias, known to predispose for the development of PVT. (cureus.com)
Patients with surgery- or pregnancy-related VTE were tested for AT, PC, and PS at least 3 months after operation or delivery, in order to avoid changes in plasma levels of the naturally occurring anticoagulants related to these conditions. (thrombate.com)
Anticoagulants are indicated for prophylaxis and/or treatment of thromboembolic complications (ischemic stroke) associated with atrial fibrillation {02}0 {02}9 {02}8 {02}7 {02}6 {02}5 {02}4 {02}3 {02}2 {02}1 {02}0 {90}9 . (drugs.com)

Antithrombin deficiency is a condition where a natural anti-clotting agent in the blood, known as antithrombin III, is either deficient or dysfunctional. (healthhype.com)
Antithrombin may not be completely deficient for the manifestations of antithrombin deficiency to arise. (healthhype.com)
On discriminant analysis, protein C activity deficiency posed a risk for ACS of 4,5 greater than non deficient subjects, and AT-III activity deficiency posed a risk for ACS of 3,5 times greater than non deficient subjects. (ui.ac.id)
Protein S deficiency was a reinforcing factor on AT-III deficient to development of ACS. (ui.ac.id)

antithrombin-III deficiency, Factor V Leiden or antiphospholipid antibodies. (mypharmacy.co.uk)

Warfarin may be started preoperatively or immediately postoperatively in patients undergoing hip fracture surgery {02}3 . (drugs.com)
therefore, a normal level while a person is on warfarin does not absolutely rule out the presence of AT deficiency. (stoptheclot.org)
Once a patient is off warfarin the antithrombin activity test should be repeated. (stoptheclot.org)
Therefore, normal levels during warfarin therapy do not reliably rule out AT deficiency. (stoptheclot.org)

Two functional assays for antithrombin III deficiency identified two separate subclasses of the type 2 defect. (medscape.com)
Vitamin C deficiency can result in an acquired vascular defect. (brainscape.com)
9 Its relatively high frequency in populations of white origin (3% to 13%), and the fact that some homozygotes for APCR remain asymptomatic for a long time led to the conclusion that this coagulation defect is mild in comparison with the inherited deficiencies of the coagulation inhibitors. (ahajournals.org)

Such studies became larger in the 80's, when protein S and protein C deficiencies were described, as well as Factor V Leiden, in 1994. (intechopen.com)
Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients. (semanticscholar.org)

For a planned major operation, correction of antithrombin levels using antithrombin concentrate products is recommended. (medscape.com)
An identifiable coagulopathy was detected in nine patients (protein C deficiency in six, protein S deficiency in two, and factor IX deficiency treated with factor IX concentrate in one). (uptodate.com)

With type II antithrombin deficiency, the quantity of antithrombin is normal but it does not function as it should. (healthhype.com)
Antithrombin 3 Deficiency, type II (medical condition): Type II Antithrombin deficiency refers the malfunction of a substance that. (rightdiagnosis.com)

Inherited hypercoagulable states are shown (in approximate order of prothrombotic potential) in Table II and Table III . (oncologynurseadvisor.com)

Rheaume M, Weber F, Durand M, Mahone M. Pregnancy-Related Venous Thromboembolism Risk in Asymptomatic Women With Antithrombin Deficiency: A Systematic Review. (medscape.com)

Three factors are important in the formation of a blood clot within a deep vein-these are the rate of blood flow, the thickness of the blood and qualities of the vessel wall. (wikipedia.org)
EMAILWIRE.COM, July 05, 2017 ) Antithrombin III is a non-vitamin, K-dependent protease that naturally blocks abnormal blood clot formation in the bloodstream. (emailwire.com)
Deficiency of antithrombin III causes various blood clot disorders in the human body. (emailwire.com)

The defects most frequently affect the proteins translation or post-translational processing, which results in decreased functional antithrombin III. (medscape.com)

Most affected neonates, however, have heterozygous antithrombin III deficiency rather than the homozygous state. (medscape.com)

In conditions like hemophilia , von Willebrand's disease and vitamin K deficiency , the blood clotting mechanism is either slow or severely impaired. (healthhype.com)
Thrombocytopenia and vitamin K deficiency are types of acquired bleeding disorders. (brainscape.com)

A clinical suspicion for antithrombin deficiency can be made in patients with: 1. (wikipedia.org)
Plasma doses depend on the clinical situation and the AT III deficiency. (treatment-diabetes-info.com)
before venography, only three patients with DVT had clinical symptoms suggesting DVT. (liposuction.com)
U. Hedner, I.M. Nilsson, Antithrombin III in clinical material. (springer.com)
Clinical management of protein C deficiency. (wikipedia.org)
This randomized clinical trial, conducted from October 2012 to May 2015, compared standard dosing (30 mg twice daily) with TEG-adjusted enoxaparin dosing (35 mg twice daily) for 185 surgical and trauma patients screened for VTE at 3 level I trauma centers in the United States. (nih.gov)
The Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT): Response to Insulin Administration and Blood Glucose Control proposal is designed to accompany the Stroke Hyperglycemia Insulin Network Effort (SHINE) clinical trial, a Phase III multicenter, randomized, controlled trial planning to determine the efficacy and validate the safety of glycemic control in stroke patients. (strokecenter.org)

Abstract -Deficiencies of antithrombin (AT), protein C (PC) or protein S (PS), and activated protein C resistance (APCR) are very well-established coagulation defects predisposing to venous thromboembolism (VTE). (ahajournals.org)

The serpin family of proteins have a highly conserved molecular structure, with 3 beta-sheets and 9 alpha-helices. (medscape.com)
Antithrombin is a serpin (serine protease inhibitor). (bionity.com)

Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system. (bionity.com)

About 5-10% of people with haemophilia A are affected because they make a dysfunctional version of the factor VIII protein , while the remainder are affected because they produce factor VIII in insufficient amounts (quantitative deficiency). (wikipedia.org)

Antithrombin actually blocks several clotting enzymes. (healthhype.com)

The prevalence of antithrombin deficiency is estimated at ~0.02 to 0.2% of the general population, and 1-5% of patients with venous thromboembolism. (wikipedia.org)
The study involved 58 VTE patients under age 45 years, 45 of whom had at least one inherited risk factor, including 14 with antithrombin III deficiency. (medscape.com)
Common conditions that result in acquired antithrombin III deficiency include disseminated intravascular coagulation (DIC) , microangiopathic hemolytic anemias due to endothelial damage (ie, hemolytic-uremic syndrome ), veno-occlusive disease (VOD) (in patients undergoing bone marrow transplantation ), sepsis, liver disease, and nephrotic syndrome. (medscape.com)
In these patients, replacement of antithrombin III using antithrombin III concentrates or fresh frozen plasma is recommended. (medscape.com)
and protein S deficiency for example, are extremely rare in patients without a family history of venous thromboembolism. (thefreedictionary.com)
Brouwer JL, Lijfering WM, Ten Kate MK, Kluin-Nelemans HC, Veeger NJ, van der Meer J. High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin. (medlineplus.gov)
Hence, antithrombin III deficiency, though rare, should be considered while evaluating young patients with stroke of unknown etiology. (who.int)
Twelve patients had progressive abdominal pain, three had gastrointestinal bleeding, and one had general malaise. (uptodate.com)
The SHINE trial will recruit 1,400 AIS patients with Type II diabetes mellitus (T2DM) and hyperglycemia, each receiving 3 days of hyperglycemia control with intravenous (IV) insulin therapy or control therapy with subcutaneous (SQ) insulin. (strokecenter.org)
No patients were found to have protein C, protein S or antithrombin III deficiency. (aafp.org)
During a median follow-up of 15 months, three patients were found to have postphlebitic syndrome manifested by pain and prominence of the superficial veins of the affected arm. (aafp.org)
Patients with inherited AT deficiency typically have levels in the 40% - 60 % range. (stoptheclot.org)
We performed a retrospective cohort study in family members (n = 793) of unselected patients with a documented venous thromboembolism and one of these deficiencies to make an estimate of this risk. (semanticscholar.org)

The claims of this new patent relate to a method of treating subjects having an antithrombin III deficiency or inflammation with the administration of recombinant antithrombin III produced in the mammary gland of a non-human mammal. (thefreedictionary.com)

Antithrombin III deficiency is an autosomal dominant disorder. (brainscape.com)

Di Minno MN, Dentali F, Lupoli R, Ageno W. Mild antithrombin deficiency and risk of recurrent venous thromboembolism: a prospective cohort study. (medscape.com)
Mild Antithrombin Deficiency and Risk of Recurrent Venous Thromboembolism: Results from the MEGA follow-up Study. (medscape.com)

An inherited deficiency of certain protein-splitting enzymes (proteases) which normally participate in the blood clotting cascade sequence. (thefreedictionary.com)
Antithrombin also affects other serine proteases of the coagulation cascade. (medscape.com)

Secondary - Caused by outside factors such as viruses, chemotherapy, other immune deficiencies and auto-immune disorders. (pptaglobal.org)
Alpha-1 Antitrypsin Deficiency is one of the most common serious hereditary disorders in the world and can result in life-threatening liver disease in children and adults and lung disease in adults. (pptaglobal.org)

[3] A frequent cause of such complications is placental infarctions . (wikipedia.org)
The incidence of VTE, bleeding complications, anti-Factor Xa deficiency, and antithrombin III deficiency. (nih.gov)

It is thought the trapping of protease enzymes in inactive antithrombin-protease complexes results as a consequence of their attack of the reactive bond. (bionity.com)

[3] There are several possible risks to treating coagulopathies, such as transfusion-related acute lung injury , acute respiratory distress syndrome , multiple organ dysfunction syndrome , major hemorrhage , and venous thromboembolism . (wikipedia.org)
In acute severe trauma, some studies also suggest a beneficial effect with antithrombin replacement. (medscape.com)

Antithrombin III is a protein in the blood that blocks abnormal blood clots from forming. (medlineplus.gov)
This low level of antithrombin III can cause abnormal blood clots (thrombi) that can block blood flow and damage organs. (medlineplus.gov)
Individuals with this condition do not have enough functional antithrombin to inactivate clotting proteins, which results in the increased risk of developing abnormal blood clots. (medlineplus.gov)

If abnormal, antithrombin antigen levels will distinguish between the two types. (medscape.com)

In either case, treatment of the underlying disease and replacement of antithrombin III using antithrombin III concentrates is the common approach used. (medscape.com)
Inherited antithrombin (AT) deficiency is associated with a predisposition to familial venous thromboembolic disease. (nih.gov)
Because THROMBATE III is made from human blood, it may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. (thrombate.com)
[3] It usually happens in the setting of another disease such as pancreatitis , cirrhosis , diverticulitis or cholangiocarcinoma . (wikipedia.org)
Quebec Platelet Disorder, also known as factor v quebec , is related to factor v deficiency and buerger disease . (malacards.org)
It is important to remember that all three elements of Virchow's triad, hypercoagulability, stasis and vessel wall disease, contribute to the pathogenesis of thromboembolism. (oncologynurseadvisor.com)

If antithrombin levels are low, a person will have a tendency to clot more easily. (stoptheclot.org)

Anatomy1

Diseases10

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Information Science3

Familial overexpression of beta antithrombin caused by an Asn135Thr substitution. (1/74)

Plasma antithrombin III deficiency in ischaemic stroke in the young. (2/74)

Enhancement of heparin cofactor II anticoagulant activity. (3/74)

The prevalence of hereditary thrombophilia in the Trakya region of Turkey. (4/74)

Complete antithrombin deficiency in mice results in embryonic lethality. (5/74)

Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. (6/74)

Mesenteric venous thrombosis: a changing clinical entity. (7/74)

Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study. (8/74)

Antithrombin III Deficiency

Antithrombin III

Protein S Deficiency

Thrombosis

Antithrombins

Methionine Adenosyltransferase

Cytochromes b

Heparin

Electron Transport Complex III

Thrombophlebitis

Encyclopedias as Topic

Thrombin

Dictionaries, Medical

Dictionaries as Topic

Heart Defects, Congenital

Cardiopulmonary Bypass

Blood Coagulation

Cardiac Surgical Procedures

Fibrinolysis

Antiphospholipid Syndrome

Antibodies, Antiphospholipid

Antibodies, Anticardiolipin

beta 2-Glycoprotein I

Lupus Coagulation Inhibitor

Lupus Erythematosus, Systemic

Cardiolipins

Venous Thrombosis

Pulmonary Embolism

Fibrin

Sinus Thrombosis, Intracranial

Coronary Thrombosis

Dithioerythritol

Cerebrospinal Fluid

Enzyme-Linked Immunosorbent Assay

Familial overexpression of beta antithrombin caused by an Asn135Thr substitution. (1/74)

Plasma antithrombin III deficiency in ischaemic stroke in the young. (2/74)

Enhancement of heparin cofactor II anticoagulant activity. (3/74)

The prevalence of hereditary thrombophilia in the Trakya region of Turkey. (4/74)

Complete antithrombin deficiency in mice results in embryonic lethality. (5/74)

Inherited thrombophilia in ischemic stroke and its pathogenic subtypes. (6/74)

Mesenteric venous thrombosis: a changing clinical entity. (7/74)

Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study. (8/74)

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