Antispermatogenic Agents: Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis.Crotalaria: A plant genus of the family FABACEAE that contains crotalarin.Indenes: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Tosyl CompoundsLung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.QuinazolinesAntineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Small Cell Lung Carcinoma: A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.ShorthandChlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.IndiaWriting: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.Archaeology: The scientific study of past societies through artifacts, fossils, etc.History, Ancient: The period of history before 500 of the common era.Pediatrics: A medical specialty concerned with maintaining health and providing medical care to children from birth to adolescence.Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.Roman World: A historical and cultural entity dispersed across a wide geographical area under the political domination and influence of ancient Rome, bringing to the conquered people the Roman civilization and culture from 753 B.C. to the beginning of the imperial rule under Augustus in 27 B.C. The early city built on seven hills grew to conquer Sicily, Sardinia, Carthage, Gaul, Spain, Britain, Greece, Asia Minor, etc., and extended ultimately from Mesopotamia to the Atlantic. Roman medicine was almost entirely in Greek hands, but Rome, with its superior water system, remains a model of sanitation and hygiene. (From A. Castiglioni, A History of Medicine, 2d ed pp196-99; from F. H. Garrison, An Introduction to the History of Medicine, 4th ed, pp107-120)Drugs, Investigational: Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Contraceptive Agents, Male: Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.IndazolesHydrazinesSpermatogenesis-Blocking Agents: Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa.Sertoli Cells: Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Blood-Testis Barrier: A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.Spermatocidal Agents: Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.Nonoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.Fungicides, Industrial: Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.Sperm Motility: Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Thymidine Monophosphate: 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.Vanadium Compounds: Inorganic compounds that contain vanadium as an integral part of the molecule.Pulmonary Alveolar Proteinosis: A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.Hashimoto Disease: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.Bronchoalveolar Lavage: Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.Petasites: A plant genus of the family ASTERACEAE. Members contain SESQUITERPENES. The common name of sweet coltsfoot is similar to the common name for TUSSILAGO.Heligmosomatoidea: A superfamily of parasitic nematodes which were formerly considered a part of TRICHOSTRONGYLOIDEA. It includes the following genera: Heligmosomum, NEMATOSPIROIDES, and NIPPOSTRONGYLUS. The hosts are rodents.Lipoid Proteinosis of Urbach and Wiethe: An autosomal recessive disorder characterized by glassy degenerative thickening (hyalinosis) of SKIN; MUCOSA; and certain VISCERA. This disorder is caused by mutation in the extracellular matrix protein 1 gene (ECM1). Clinical features include hoarseness and skin eruption due to widespread deposition of HYALIN.Granulocyte-Macrophage Colony-Stimulating Factor: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

Testin induction: the role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat sertoli cells. (1/26)

Results of previous in vitro and in vivo studies have illustrated that the expression of testin by Sertoli cells is tightly associated with the disruption of Sertoli-germ cell junctions. In the present study, treatment of rats with cadmium chloride (CdCl(2)), which disrupted the inter-Sertoli tight junctions, failed to induce any changes in testicular testin expression. In contrast, lonidamine, an antispermatogenic drug that rearranges the Sertoli cell membrane microfilament structure causing a disruption of Sertoli-germ cell adhesion junctions, induced a drastic increase in testicular testin expression when administered orally. Lonidamine-induced Sertoli cell testin expression involved both ongoing RNA and de novo protein synthesis. Basal testin expression remained stable during the 27-h incubation with actinomycin D but required de novo protein synthesis in vitro. An inhibitor of protein kinase A, Rp-cAMPS, caused a 50% inhibition of Sertoli cell testin expression at 10 microM within 24 h. A biphasic response was noted in testin expression when forskolin was included in the Sertoli cell culture, and high concentrations of cAMP analogues (1 mM) rapidly reduced testin expression. However, lonidamine can abolish the inhibitory effect of cAMP analogues on Sertoli cell testin expression. These results illustrate that the induction of testin expression may involve several signal transduction pathways.  (+info)

The contribution of Asian scientists to global research in andrology. (2/26)

AIM: To present a personal account of the involvement of the World Health Organization (WHO) in the collaborative development in Asia of those areas of andrology concerned with male contraception and reproductive health. METHODS: The andrology training through workshops and institution support undertaken by the WHO Human Reproduction Programme (HRP) and how they contributed to the strengthening of andrology research in Asia are summarised. RESULTS: The author' s experience and the Asian scientific contributions to the global research in the following areas are reviewed: the safety of vasectomy and the development of new methods of vas occlusion; gossypol and its failure to become a safe, reversible male antifertility drug; Tripterygium and whether its pure extracts will pass through the appropriate toxicology and phased clinical studies to become acceptable contraceptive drugs; hormonal methods of contraception for men. CONCLUSION: The WHO policy of research capacity building through training and institution strengthening, together with the collaboration of Asian andrologists, has created strong National institutions now able to direct their own programmes of research in clinical and scientific andrology.  (+info)

Hormonal contraception in the male. (3/26)

The hormonal approach to male contraception is based on the suppression of gonadotrophin secretion with secondary suppression of spermatogenesis. This can be achieved by administration of testosterone or other androgen alone, but combined administration with a progestogen or GnRH analogue allows the dose of testosterone to be reduced to physiological replacement doses. This approach has been investigated for many years but without identification of a regimen which results in sufficient suppression of spermatogenesis to provide ensured contraception in all men, safely and conveniently. The reasons for this are discussed, and recent developments towards a regimen that fulfills all these criteria are described. Crucial to development of any new product is that it will be used: surveys of both men and women indicate firmly positive attitudes towards a 'male pill'. There are, therefore, grounds for cautious optimism that the next decade may see the introduction of the first novel male contraceptive for several hundred years.  (+info)

Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. (4/26)

The oral male contraceptive agent 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide (AF2364) is a new analogue of indazole-carboxylic acid. AF2364 was orally administered to rats at 50 mg/kg body weight once weekly for five consecutive weeks. The effects on fertility efficacy, hormonal profile, organ weights, tissue morphology, and serum microchemistry were examined. Complete infertility was noted in rats 29 days after the initial dose of AF2364 and continued until 90 days. Fertility resumed in 25% of the group after 104 days and had resumed in 75% of the rats by the last mating at 197 days. Morphological examination of the testis showed rapid exfoliation of elongated spermatids and the generation of large multinucleated cells 6 days after the first treatment, with depletion of most germ cells after 40 days. Normal spermatogenesis was noted in 95% of the tubules in the animals that were fertile at 210 days. Morphological analysis of the epididymal compartments revealed reduced lumen size, whereas the prostate exhibited an increase in the glandular lumen with a reduction in epithelium height. No morphological changes were detected in the kidney, liver, and cerebrum by light microscopy. Kidney and liver function, as evaluated by serum chemistry, were not affected by the drug treatment. AF2364 did not alter the levels of FSH, and only minimal changes were noted for LH and testosterone, suggesting that the hypothalamic-pituitary-testicular axis was not affected. These results illustrate the potential of AF2364 as a male contraceptive.  (+info)

Lupron depot prevention of antispermatogenic/antifertility activity of the indenopyridine, CDB-4022, in the rat. (5/26)

The goals of this study were to determine the CDB-4022 dose-response relationship for induction of acute decreases in testicular weight and germ cell depopulation in rats; establish the threshold dose of CDB-4022 required to induce infertility; and investigate whether CDB-4022-induced testicular damage could be prevented by a GnRH agonist (Lupron Depot). Reduction of testis weight and germ cell depopulation were observed 7 days after a single oral dose of 1 mg CDB-4022/kg, whereas 0.5 mg/kg had no observable effect. These effects were maximal at 12.5 or 25 mg CDB-4022/kg. After a single oral dose of either 2.5 or 5 mg/kg, CDB-4022 induced infertility in five of five treated rats by Week 5, whereas only one of five males was rendered infertile at a dose of 1 mg/kg. Proven fertile male rats (6/group) were treated with vehicle, CDB-4022 alone (2.5 mg/kg on Day 0), CDB-4022 plus Lupron Depot (on Weeks -1, 2, 5, and 8), or Lupron Depot alone. Control males demonstrated normal fertility throughout a 32-wk cohabitation period. Five of six rats were rendered transiently infertile with Lupron Depot alone, but all recovered fertility. CDB-4022 treatment resulted in infertility in all six rats, and only one of six regained fertility. Combined treatment also caused infertility in all six rats, but four of six recovered fertility (P = 0.08 compared to CDB-4022 alone). Testicular weight was decreased in the three treatment groups compared to vehicle controls; testicular weights were ranked from highest to lowest as follows: vehicle > Lupron Depot > Lupron Depot + CDB-4022 > CDB-4022. The tubule differentiation index of Lupron Depot-treated rats (96 +/- 4%) was not different from vehicle-treated rats (100%). CDB-4022 treatment decreased the number of differentiating tubules (15 +/- 8%). Lupron Depot plus CDB-4022 treatment resulted in a greater number of differentiating tubules (53 +/- 12%) than CDB-4022 alone, but this was still lower than vehicle- or Lupron Depot-treated rats. These data indicate that 2.5 mg/kg of CDB-4022 was the oral threshold dose that caused testicular damage rendering the majority of adult male rats permanently infertile within the study interval; 12.5 mg/kg of CDB-4022 induced maximal testicular damage. Suppression of gonadotropins and/or testosterone production by treatment with Lupron Depot before and after CDB-4022 prevented the CDB-4022-induced irreversible testicular damage.  (+info)

Expression of the cystic fibrosis transmembrane conductance regulator in rat spermatids: implication for the site of action of antispermatogenic agents. (6/26)

To establish whether cystic fibrosis transmembrane conductance regulator (CFTR) is functionally expressed in the testis, we subjected spermatogenic cells from rat testes to analysis of CFTR mRNA, protein and channel activity. CFTR mRNA was detected in the testes of mature but not immature rats using reverse transcription-polymerase chain reaction analysis. Western blot analysis performed with a CFTR specific antibody revealed immunoreactivity in the membrane extract of spermatogenic cells. Immunohistochemical studies localized CFTR in round and elongated spermatids, but not in the fully developed spermatozoa. Using a whole-cell patch clamp technique, we recorded an inward current activated by intracellular cAMP (100 micromol/l) in round spermatids. The current displayed a linear I / V relationship and was inhibited by diphenylamine-2-carboxylate (DPC), a chloride channel blocker. Transfection of the rat germ cell CFTR cDNA into human embryonic kidney (HEK) 293 cells caused the expression of a cAMP-activated chloride current with CFTR characteristics. The current was completely blocked by the antispermatogenic agents 1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid, lonidamine (500 micromol/l) and 1-(2,4-dichlorobenzyl)-indazole-3-acrylic acid, AF2785 (250 micromol/l). These results taken together provide evidence that CFTR is differentially expressed in spermatids during spermiogenesis. We speculate that CFTR may interact with aquaporin to bring about cytoplasmic volume contraction which is an essential feature of spermiogenesis.  (+info)

Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats. (7/26)

The present studies were undertaken to determine the testicular cell type(s) affected by the antispermatogenic indenopyridine CDB-4022. At the oral threshold dose (2.5 mg/kg), CDB-4022 induced infertility in all males. CDB-4022 did not alter (P > 0.05) Leydig cell function as assessed by circulating testosterone, seminal vesicle, and ventral prostate weights or body weight gain compared to controls. Conversely, CDB-4022 reduced (P < 0.05) testicular weight, spermatid head counts, and percentage of seminiferous tubules undergoing spermatogenesis. In a second study, adult male rats received a maximally effective oral dose of CDB-4022 (12.5 mg/kg), dipentylphthalate (DPP; 2200 mg/kg; a Sertoli cell toxicant), or vehicle and were necropsied 3, 6, or 12 h after dosing to determine acute effects. Serum inhibin B levels were suppressed (P < 0.05) by 6 h after CDB-4022 or DPP treatment, but epididymal androgen-binding protein (ABP) levels were not altered (P > 0.05), compared to controls. CDB-4022 and DPP increased (P < 0.05) the percentage of tubules with apoptotic germ cells, particularly differentiating spermatogonia and spermatocytes, by 12 h after dosing. Microscopic examination of the testis indicated a greater degree of vacuolation in Sertoli cells and initial signs of apical germ cell sloughing/shedding by 3 or 12 h after CDB-4022 or DPP treatment, respectively. In a third study, prepubertal male rats were treated with vehicle, 12.5 mg/kg of CDB-4022, or 2200 mg/kg of DPP, and the efferent ducts of the right testis were ligated 23 h before necropsy. Seminiferous tubule fluid secretion (difference in weight of testes), serum inhibin B levels, and ABP levels in the unligated epididymis were reduced (P < 0.05) at 24 and 48 h after dosing in CDB-4022- and DPP-treated rats compared to controls. Collectively, these data suggest that CDB-4022 disrupts spermatogenesis by inducing apoptosis in early stage germ cells via a direct action on the Sertoli cell.  (+info)

Rabbit epididymal secretory proteins. II. Immunolocalization and sperm association of REP38. (8/26)

Polyclonal antibody was used to partially characterize REP38, a major rabbit epididymal secretory protein. Western blot analyses and immunohistochemistry indicated that REP38 is only expressed in regions 5 and 6 of the epididymis (corpus epididy-midis) and is localized in the supranuclear region and microvilli of the principal cells in these regions. It was not expressed in other tissues of the body. In region 8 (cauda epididymidis), REP38 was detected in the luminal border and cytoplasm of scattered principal cells, indicating that it may be reabsorbed in this region. This protein accumulated on the sperm plasma membrane downstream of region 5 and was localized predominantly over the acrosomal and postacrosomal regions of the head and the middle piece. Although tightly bound to epididymal sperm, REP38 migrated to the equatorial segment under conditions in vivo that would promote capacitation. When tested in vitro, anti-REP38 IgG reduced the percentage of ova fertilized in a concentration-dependent manner, apparently by blocking sperm-egg fusion.  (+info)

An indazole carboxylic acid derivative with antispermatogenic and potential antineoplastic activity. As a male contraceptive, tolnidamine may irreversibly inhibit sperm production. This agent is less nephrotoxic than ionidamide, but it is just as effective in antispermatogenic action to ionidamide.
1 Answer - Posted in: lupron, lupron depot, lupron depot 3.75 mg - Answer: Lupron Depot 3.75mg works for 1 month, as it needs to be administered ...
Lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid], a well-known antispermatogenic drug, was studied for the first time in pubertal mice to assess its possible effects on spermatogenesis. Male CD1 mice were orally treated on Postnatal Day (PND) 28 with a single dose of LND (100 mg/kg body weight) and sacrificed on PND30, PND42 ...
[150 Pages Report] Check for Discount on 2016 3,4-Dichlorobenzyl Chloride (CAS 102-47-6) Industry Market Report report by Prof Research. The Global and Chinese 3,4-Dichlorobenzyl Chloride Industry, 2011-...
According to the Chinese calendar, on February 8 we leave the Year of the Sheep and enter the Year of the Monkey. But for me, 2015 was the Year of Boomeritis.. Perhaps youve heard of the term. It was first coined in 1999 by Dr. Nicholas A. DiNubile, an orthopedic surgeon at the Hospital of the University of Pennsylvania, who defined it as any injury incurred by a Baby Boomer, usually in the course of doing some kind of physical activity such as exercising or playing a sport. But I prefer to define it more broadly as a cognitive condition in which we Boomers mistakenly assume that we are the same people physically, mentally, emotionally, and spiritually as we were decades earlier. And act like it.. So imagine my rude awakening at the gym when I believed I could handle the same vigorous weight-training regimen I performed in my 30s. Wrong. I tore muscles in my right shoulder and pulled a ligament in my left wrist, which together required a year of physical therapy to heal. Now lest it appear that ...
Changing political agendas have shaped models of urban regeneration in Scotland. Latterly, this has focussed on social justice and inclusion reflecting the policy direction of new labour and the Scottish Parliament. In addition the experience of community regeneration and imposition of a national Community Planning agenda, has contributed to the development of strategic instruments for tackling poverty and exclusion in its cities. These factors influence the architecure of the urban areas.. ...
Hello, We have been trying to conceive for 4 years. 2 weeks ago I started a new IVF cycle with Lupron Depot (a single shot). Somehow two weeks after the shot I conceived naturally. I read a lot of b...
I am in my fourth month of Lupron Depot Treatment and I have started bleeding a little bit and I shouldnt be. Has anyone ever had this problem before?
...ABBOTT PARK Ill. March 11 ... For many patients with advanced prostate cancer Lupron Depot is an i...Lupron Depot is currently available in one-month (7.5 mg) three-month...,Abbott,Seeks,FDA,Approval,of,a,New,Six-Month,45-mg,Formulation,of,Lupron(R),Depot,for,the,Palliative,Treatment,of,Advanced,Prostate,Cancer,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
You are viewing an interactive 3D depiction of the molecule 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-(4-morpholinyl)-3,7-dihydro-1h-purine-2,6-dione (C18H23Cl2N5O3) from the PQR.
Benzyl-(2,4-dichlorobenzyl)amine/ACM14501872 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Health,...A Drug That Improves Survival Would Earn a 50 Percent Patient Share in... ...WALTHAM Mass. April 6 /- Decision Resources one of the... ...,Interviewed,Experts,Expect,Taxotere,to,Increase,Overall,Survival,More,Than,Other,Drugs,,Including,Lupron,Depot,,in,Stage,III,Prostate,Cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. In connection with a project in which a user generates a predictive model based on historical data about a system being modeled, and in which the project includes a series of user choice points and actions or parameter settings that govern the generation of the model based on rules, which direct the user to select and apply an optimal model.
I am really looking forward to having another child, so after 2 yrs of continuous NuvaRing and 6mos of Lupron Depot, I stopped 08/24/2014. On 08/27/2014, I got what I thought was a period.
The antioxidant activity of Morinda lucida (Benth.) stem bark was investigated. Air dried stem bark of Morinda lucida was powdered and extracted with 95 % v/v methanol and the extract concentrated at 40oC using rotary evaporator. The total phenolic composition of methanolic extract of air - dried stem bark was estimated using spectrophotometric method. Phenolic composition was calculated to be approximately 80 %. Antioxidant activity of the extract was determined using its ability to prevent the oxidation of â-carotene. Ferric reducing ability of extract was also determined. Antioxidant and ferric reducing activities exhibited by plant extract were concentration dependent. Plant extract achieved a maximum antioxidant activity of 6% within 40minutes. The total phenolic content, antioxidant activity and reducing power of the extract had direct relationship. ...
Children and mothers play an important role in policy efforts to regenerate the city. This dissertation deals with this prominence of children and mothers in urban policies in Rotterdam, the Netherlands. It departs from the observation that mothers, in particular, matter in urban policy making and the struggle of former industrial cities to reinvent themselves. I was curious about why mothers and children featured so very prominently in urban policies in Rotterdam and also how this resulted in policy practices and what was done in these practices. For this purpose, I did participatory, ethnographic research in a range or parenting guidance practices. I was interested in what goes on in the room. What happens when policy ambitions for the city enter a classroom, school kitchen, family home or community centre where "parenting guidance" is taking place? What do professionals such as teachers, pedagogues and social workers produce together with participating mothers? And how does this relate to ...
Symplocos lucida (es); Symplocos lucida (fr); Symplocos lucida (it); 日本灰木 (zh-tw); Symplocos lucida (uk); Symplocos lucida (ast); Symplocos lucida (ru); Symplocos lucida (la); Symplocos lucida (de); Symplocos lucida (vi); Symplocos lucida (ga); Symplocos lucida (en); Symplocos lucida (bg); Symplocos lucida (nl) especie de planta (es); উদ্ভিদের প্রজাতি (bn); espècie de planta (ca); Art der Gattung Symplocos (de); lloj i bimëve (sq); բույսերի տեսակ (hy); вид растение (bg); specie de plante (ro); вид рослин (uk); soort uit het geslacht Symplocos (nl); speco di planto (io); especie de planta (gl); вид растений (ru); species of plant (en); نوع من النباتات (ar); druh rostliny (cs); מין של צמח (he ...
LUPRON DEPOT 3.75mg (Leuprolide) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
You are viewing an interactive 3D depiction of the molecule {3-[(3,4-dichlorobenzyl)amino]propyl}(diethoxymethyl)phosphinic acid (C15H24Cl2NO4P) from the PQR.
I just finished a round of Docetaxel in October, and got my 2nd 6-month Depot shot of Lupron in December ( I got both my 1st chemo and my 1st Lupron in late Jun...
For twenty-five years Lynne Millican has been promoting awareness of, and trying to prompt investigations into, the serious problems associated with the drug Lupron. ____________________________________ In 1989, I received a prescription for the drug Lupron from a world-renowned Boston hospital for treatment of endometriosis and infertility. Given the prestige of the institution, and the trust…
For twenty-five years Lynne Millican has been promoting awareness of, and trying to prompt investigations into, the serious problems associated with the drug Lupron. ____________________________________ In 1989, I received a prescription for the drug Lupron from a world-renowned Boston hospital for treatment of endometriosis and infertility. Given the prestige of the institution, and the trust…
Gorpils Orange information about active ingredients, pharmaceutical forms and doses by Gepach International, Gorpils Orange indications, usages and related health products lists
This database and website are updated and enhanced by Pesticide Action Network North America (PANNA). The project is made possible by our Sponsors and by PANNA general funds. We need your support to maintain and improve this system. Please support the database and website - donate to PANNA ...
The scientific community at large have denounced use of Lupron, a prostate cancer drug, for treatment of autism. But Dr.Mark Geier and his son who pioneered the protocol persist, raising concerns.
Yipdee Dapdee Doooooo!!! Woooohoooo! Just got the email from my nurse... basically a Lupron protocol (I cant tell if this is long-lupron or micro-dose lupron -- havent done lupron before). Here are the details: 5/12 - Start Lupron 10U + Dexamethasone 5/16 - Last BCP 5/20 - Suppression check + BW 5/22 - Decrease to…
I am so glad to hear your news. I agree, that it is really a low dose and that everything should be fine. on 12/30 I had to go to the ER for a racing heart rate that would not go down. It was 169 laying down. It was called SVT(supraventicular tachycardia). The doctor there said it can happen to anyone and they see 16 year olds come in with it. They had to give me a medicine to "reboot my heart." I was very upset about that since I was 20.5 along and it would definitely cross the placenta line. Everything was fine and I have had a ultrasound and seen the OB since then. So if I can have that without hurting the babies, I doubt that such a tiny little dose of Lupron for a few days would do anything ...
Injection #1 is complete. I almost forgot how easy Lupron is. Ill take the Dexamethasone with dinner. Im coming down with a little cold. It started with a sore throat yesterday afternoon and today its morphed into swollen glands and a headache. Fingers crossed rest, liquids, and vitamin C can shake this thing pronto. Better…
There are some potentially serious side effects of Lupron, and blood in the urine is one of them. This eMedTV page explains what to do if you are using this medicine and notice blood in your urine. This article also links to more detailed information.
I have endo, I have had a ruptured cyst, I have had kidney pain for 24 days & counting, I am in constant discomfort. Do I really need a full hyster or has anyone had luck with Lupron? I did have 1 Lu...
Lupron Depot is a hormone drug used to treat prostate cancer that works by suppressing testosterone. Heres what you should know about possible side effects and complications.
OLD SALT, thanks for your interest, it is greatly appreciated. Following is my initial biopsy.. Had my prostate removed the first part of March, 2014. Following is the lab report dated Jan 24, 2014.. PSA 11.31 ng/ml, T1c, DRE normal.. Left side. Base Adenocarcinoma 7(4+3) 100%. Mid "" 7(4+3) 30 %. Apex Benign. Lat Base carcinoma 7(3+4) 100% right side nodes were all benign. Lat Mid "" 7(4+3) 90 %. Lat Apex "" 7(3+4) 100%. There was also a note concerning left base tumor, indicates perineural invasion.. Treatment after surgery was 46 radiation visits and 2 yrs. of Lupron Depot. ...
I wish I had known this when a doctor my sister-in-law (a nurse) recommended told us my father had prostate cancer based upon his PSA. He had an enlarged prostate, no pain and urinated frequently. The doctor insisted on prescribing Lupron for the rest of his life (it should only have been for 1 year). The doctor was wrong. We didnt know it. We followed the prescriptions for Lupron which over a five year period created various complications that the MIC and the doctor did not note or forewarn us of. One of them was increased emotional stress and a change in body chemistry hormones. (lupron is a female hormone). In any case my father who had no other medical condition (no high blood pressure, no heart condition, etc.) and whose body had been pristine and fairly clean (he was very active-gardened and we thought of him as a strong man with a strong immune system) now was receiving dosages of chemicals. Who scientifically knows how this impacted his body, his mind, his soul? All I know is WHAT ...
I received donated Lupron for my FET a couple years ago and I have donated Lurpon to a fellow TTCer that cycled after me. If someone is asking for Lupron b/c they are about to start IVF/FET I would assume they have a script for it. If I was caught with Lupron in my possession it wouldnt be illegal b/c I have a script from my RE. I understand the liability issues but I also think it would be amazing to have a place to ask for donated meds or be able to donate. I donated some back to my RE at the end of my last cycle also ...
I found out my IVF nurse is also an IVF patient. She explained that her first cycle was Antagonist and her second was Lupron. She responded much better to the Lupron cycle. Lets hope I am the same, mmmkay? I can then forgive the horrendous side effects. She then asked if her new trainee could be at my next monitoring appointment. My response, "You know what they say... ones company, twos a crowd and threes a party." ...
I started on OCPs yesterday and am scheduled to start Lupron next week. They now tell me I have to have a saline sonogram prior to starting Lupron as my last HSG was in August 2013 and their protocol recommends every 6 months during IVF. I am not enthused about the same, but am going along with their recommendation. Did any of u also get a saline songram every 6 months? Seems a little excessive to me but they say they want to make sure they are no polyps or anything that will affect the FET implantation. I guess my FET will be the third week of May or so. Anyone else on the same cycle ...
These videos are from patients like you. They are not made by doctors or nurses. Protocols are also very individual and whats shown here may not apply to you. You must verify all advice, instructions and dosages with your clinic before going ahead with your medication ...
Recombinant Human Testin protein is an Escherichia coli Full length protein 1 to 421 aa range, | 90% purity and validated in SDS-PAGE, MS.
i suffer now for 5 years no releif and my bones joints muscle tissue are failing my body! Lupron should never be given to anyone!
Small-cell lung cancer (SCLC), which accounts for up to 15% of all lung cancers, is the most aggressive lung cancer subtype and lacks effective early detection methods. Paraneoplastic encephalomyelitis/sensory neuronopathy (PEM/SN) is one of several rare autoimmune disorders associated with SCLC (reviewed in Chapter 1). Most patients with PEM/SN have underlying SCLC and harbor high titers of antibodies against normally neuronally expressed Hu proteins. Anti-Hu reactivity is also present in approximately 16% of SCLC patients without PEM/SN (Chapter 2). Abnormal expression of neuronal Hu proteins in SCLC tumors is thought to result in the generation of autoantibodies that may cross-react with the nervous system, possibly triggering PEM/SN. We have shown that, like human SCLC patients, engineered SCLC-prone mice misexpress Hu proteins (Chapter 3). In addition, 14% of the mice harbor above background titers of anti-Hu antibodies, similar to the situation in human SCLC patients. The mice appear to ...
The Blade Runner films focus on the meaning of humanity; a University of Melbourne bioethicist finds they also foreshadow future ethical concerns over cloning.
Endometriosis. LUPRON DEPOT® (leuprolide acetate for depot suspension) 3.75 mg for 1‑month and 11.25 mg for 3‑month administration are prescription medications used for the management of endometriosis, including pain relief and reduction of endometriotic lesions. LUPRON DEPOT 3.75 mg for 1‑month and 11.25 mg for 3‑month may be used with daily norethindrone acetate 5 mg as add‑back therapy for initial management of the painful symptoms of endometriosis and for management of recurrence of symptoms. Add‑back therapy is intended to reduce the thinning of bone and reduce hot flashes associated with LUPRON DEPOT. For safe and effective use of norethindrone acetate with LUPRON DEPOT 11.25 mg, refer to the norethindrone acetate prescribing information.. Initial treatment course of LUPRON DEPOT (whether used alone or with add‑back therapy) is limited to 6 months. A single retreatment course of not more than 6 months of LUPRON DEPOT plus add-back therapy may be used if symptoms recur. ...
In its commitment to reducing carbon dioxide and curtail the effect of greenhouse gases derivable mainly from gaseous emissions and industrial pollution, Lafarge Africa Plc has signed an agreement with the Ogun state Ministry of Forestry on the project that will allow processing and conversion of agro-forestry waste to energy.. The Regional Vice-President, Industrial Ecology, Middle East and Africa, Lafarge Africa Plc, Mr. Pierre Delcroix, said this in Abeokuta at the signing of the Memorandum of Understanding with the state government on the project.. He noted that the project was aimed at reducing the effect of greehouse gases through the usage of agro-forestry residues to fire cement plants instead of gas. The company has undertaken such a project in Uganda, Kenya, and Tanzania. This form of energy option will make for a situation that will ensure the re-generation of the almost depleted state forest reserves, training of farmers on modern farming methods and general investment in ...
I am a 31 year old female who was diagnosed with Endometriosis about 3 years ago. After my Lap procedure and consulting with multiple doctors....t...
analog of naturally occurring gonadotropin releasing hormone (GnRH or LHRH.) The analog possesses greater potency than the natural hormone. Lupron acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Following an initial stimulation, chronic administration of Lupron results in suppression of ovarian steroid production. This effect is reversible upon discontinuation of drug therapy. In humans, subcutaneous administration of single daily doses of Lupron results in an initial increase in circulation levels of LH and FSH, leading to a transient increase in levels of the gonadal steroids estrone and estradiol. However, continuous daily administration of Lupron results in decreased levels of LH and FSH. In premenopausal females, estrogens are reduced to post-menopausal levels. These decreases occur within two to four weeks after initiation of treatment. Lupron produces numerous side effects including cardiovascular symptoms like congestive heart ...
The level at which to begin hormone therapy is not as important as how fast the psa is rising. My psa is doubling about every 7 months now and if I chose to go to my urologist he would recommend another shot of Lupron. I have been dealing with a dianosis of a 50% chance to survive two years for 5.5 years. The only treatment I have chosen to take is one shot of Lupron, to shrink the prostate, and 40 radiation treatments. I refuse to let cancer be what defines my life and totally eliminated the stress from my life, THAT is why I am here. I will not take another shot of Lupron until golf season is complete and only then if I am convinced it will extend my life. Hormone therapy eventually does nothing to help and then the doctors will push you into chemo which may kill you or give you 4 to 6 months of a living hell. I watched my wife die after 2 years of intense treatments and there has to be an easier path. The side effects of Lupron are life changing. You will have no interest in sex and pretty ...
LUPRON DEPOT-3 MONTH 22.5mg (Leuprolide) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
I hope that all of you had a very Merry Christmas, Happy Chanukah, Kwanzaa or whatever you celebrate. As for me my Christmas was ok, nothing worth jumping all over about, just ok. I have been blessed with so many friends though, and getting cards from all of them is always so nice. The only bad thing this year was the lack of my intelligence to obviously inform EVERY person that got a card from me as to the "state of the union" because I got 3 cards today, and have 8 total in which I have been asked the "addition/s to the family" question. Now you would think that most of them would get the hint when they got a photocard that just had the 3 of us in it, and no letter making any announcements to the effect of an addition anytime soon. I blame myself for this though because up until I found out just how damn infertile I was, I wasnt worried about sharing my little problem, but now that IVF is being "forced" on me that freedom to discuss has changed. I just dont know how people will react to the ...
Ok, first off, sorry I didnt get a chance to update yesterday. It was a VERY long day and I crashed really early last night. But onto the news…. Had an ultrasound. I was at around 1,200 grams before. Yesterday? About 650 grams!! So weve cut the size down almost in half so far!! He had wanted to get me down to around 600 grams for surgery. He could do it at 1,200 but it would mean much longer under anesthesia and bleeding risks. Well, now that were down, hes ready to get me on the schedule. I dont have a specific date yet. His nurse will be following-up with me to schedule me about a month or so from now.. Sometime around the end of September I will be having my surgery.. He thinks that by then, I may even be down to about 400 grams because the Lupron is still in my system for another two months. So even better. The Lupron TOTALLY worked for me.. Right before surgery, Ill have a final ultrasound just to get a last-minute check on things and Ill also need bloodwork for cross and type for ...
So ... shots class wasnt so bad. It was nice to be in a room full of other people who "get it," and I think E even had a little fun poking the little practice butt with the needle. My protocol doesnt include Lupron, so we really wont have that many shots. Well, at least until we get to the daily PIO, but we wont think about that yet. And they said I could switch back to my other BCPs for the last two weeks. Yeah ...
Thanks to Lupron, the last couple of nights I went from boiling to freezing, boiling to freezing. It has been a vicious, sweaty, goosebumpy circle. Its been ongoing throughout the day and Im expecting the body temp fluctuations to be around for a bit. Thank god for layers! The sweater goes on. The sweater comes…
I start Lupron on June 15th, then all the other meds will follow accordingly. I talked to the coordinator at the clinic about doing Crinone instead of the PIO injections and she seemed to think it would be okay, but when I got my calendar it still had the PIO on there. :\ I asked her about it and she said that Dr. K "strongly encourages" doing the PIO injections at least until the pregnancy is confirmed. UGH!! Not cool. I suppose I can deal with a daily shot in the ass for 3 weeks rather than the normal 12 weeks! Kevs gonna have to brush up on his shot administering skills....or maybe I can get my moms cousin, whos an RN, to do them for me ...
Hooray!! Scary I know but I agree about just taking it one day at a time, one step at a time. It really helped me to make myself an IVF calendar with all my meds (even PNVs) needed for each day so that I could just cross each one off as I went. That way I never worried that I forgot something and I ONLY had to focus on the next immediate shot, not on everything still yet to do. It made it feel very manageable for me and was sort of nice to even look back to see how far Id come. And you are right about the Lupron injections - they are easy! Just pinch and stick - half the time you may not even feel anything. The first one is the worst because of the anticipation and then youll get used to it before you know it. (((Hugs!!))). ReplyDelete ...
Hi, I have been diagnosed with endo on July 2008. I had my laparoscopy and my doctor wanted me to go on Lupron, but I refused. I have a new doctor now and he...
Sunnyvale, CA, 94086. You can check out our latest projects, meet Zener the cat, shop for holiday gifts, and share in food and conversation. Well also be running a hangout for non-local attendees, and will post the link on our Google+ page when it goes live.. Photo by Steve Hoefer.. ...
agreed to license its endometriosis treatment, elagolix, and any future follow-on products.. Neurocrine gets $75 million up front -- not bad for a company that had just $66 million on the books at the end of last quarter -- and Abbott will take over paying for developing elagolix, including expensive phase 3 trials. If the partnership is successful, Neurocrine is eligible for about $500 million in milestone payments and royalties on potential sales.. The choice of partners seems good; Abbott has experience in the marketing of endometriosis treatments as it sells Lupron Depot. In endometriosis, the uterine lining begins to grow outside the womb. This can cause infertility and there is no cure.. But were getting a little ahead of ourselves. Neurocrine doesnt expect that theyll file for marketing approval until 2013. The data looked good for the phase 2 trials, but thats no guarantee that phase 3 trials will be a success.. Neurocrine says that the drug is unique because it only partially ...
Quick Onset of Side Effects of Casodex and Lupron If a persons T is close to low normal, it is possible for hot flushes can start just a few days after the first Lupron shot. Before I had the Firmagon and Lupron shots in 2016, I did not know what.... ...
However, I did it, and it was fine. Did I slack a little in my classes? Um, yes. Did I sleep in my car on my lunch breaks? Every day. In my opinion it was worth it, and if I had it to do over, I would do it again. It was what I had to do to get pregnant and that made it worth it in my mind.. The major side effects that I had are as follows:. Birth Control Pill: Crazy! So, so, horribly crazy! Seriously? This was the worst part for me. I really wanted to punch everyone I encountered, in the face, for three entire weeks. It was pure hell.. Lupron: Tired! So, so, horribly tired! Tired all the time! I also noticed that my skin, nails, and hair became really dry starting with Lupron and lasting the entire time. Im guessing it was all of the hormones.. Follistim: Bloated! So, so, horribly bloated! Toward the end, and especially after the retrieval, my pants didnt fit. I wore dresses every day from about 6 days of stims and on.. HCG Shot: Ouch! If you havent had one, be ready: it makes your butt ...
A blog for my whimsy. Including articles on web development, social issues, creative writing, graphic design, and whatever else I can think up.
My wonderful IVF coordinator K called today morning to let me know about my protocol and schedule. Like I said earlier, I am going to be on an Estrace-only protocol (as opposed to the Lupron/Estrace protocol that is twice as long). I am supposed to give her a call the day AF comes and I…
Last night, March 13, I took my final Lupron shot in this protocol. It began on February 10, so that seemed like a long time! Some tips Ive learned about the tummy shots: sit down and lean forward so you can get a good pinch of skin near your belly button; put the needle to…
In a Phase IV pharmacokinetic/pharmacodynamic study of patients, LUPRON DEPOT-3 Month 11.25 mg (N=21) was shown to be comparable to monthly LUPRON DEPOT 3.75 mg (N=20) in relieving the clinical signs/symptoms of endometriosis (dysmenorrhea, non-menstrual pelvic pain, pelvic tenderness and pelvic induration). In both treatment groups, suppression of menses was achieved in 100% of the patients who remained in the study for at least 60 days. Suppression is defined as no new menses for at least 60 consecutive days.. In controlled clinical studies, LUPRON DEPOT 3.75 mg monthly for six months was shown to be comparable to danazol 800 mg/day in relieving the clinical sign/symptoms of endometriosis (pelvic pain, dysmenorrhea, dyspareunia, pelvic tenderness, and induration) and in reducing the size of endometrial implants as evidenced by laparoscopy.. The clinical significance of a decrease in endometriotic lesions is not known at this time, and in addition laparoscopic staging of endometriosis does not ...
Ovulation induction cycles are usually "controlled" by one of the drugs Lupron, Cetrotide, or Ganirelix. Ovulation cannot occur when a patient is receiving one of these products because they all prevent the LH surge, albeit by different mechanisms.. Lupron essentially blocks the production of estrogen by the pituitary which is why it is also an effective treatment for endometriosis. Ganirelix and Cetrotide act more rapidly than Lupron to block FSH/LH production by the pituitary. Ganirelix and Cetrotide can be given in lower doses for shorter periods of time.. An IVF cycle requires that mature eggs develop so that they can be retrieved and fertilized. Lupron/Ganirelix prevents ovulation of the eggs before they can be retrieved. If they are ovulated prematurely, the IVF cycle will be "lost". This is one reason why careful cycle monitoring, precise manipulation of the various fertility drugs and physician experience are critical to IVF success. Once the eggs are mature, an injection of hCG is given ...
can a fibroids be removed 54 and at my last exam the Dr. I was injected with Lupron Depot 1995, and went from size 6 to size 18 in just few weeks. So when you heat the castor oil pack in the microwave, use a plate or Pyrex rather than a plastic container. The doctors and specialists at South Jersey Fertility Center are highly experienced in fibroid removal. Or does it just not make sense on how it can help get rid of fibroids naturally.
Men with advanced prostate cancer and children with precocious puberty may benefit from Lupron. This eMedTV resource takes a look at this prescription drug, including dosing tips and potential side effects. Lupran is a common misspelling of Lupron.
It comes with some pretty nasty side effects: headache, acne, mood swings, hot flashes, itching, weight gain, etc. I spent most of yesterday with an ice pack on my head and Ive had a pretty rough headache this afternoon. But, its nothing I cant easily shake. The silver lining is the shots themselves are easy for me to administer myself, since they are subcutaneous in the lower abdomen ...
We made it. On Tuesday we transferred two perfect looking embryos. Ive been on bed rest since then and Ive been reflecting on the last month. The last I checked in I had my endometrial scratch and baseline. The day afterwards, I stopped birth control and got to start my favorite medication again... Lupron. Lupron…
Its been more than three months since my last - and final - injection and Id hoped the Lupron would be out of my system by now. When I forget to take my "crazy pill", I become a completely different person... someone whos short-tempered and wants to eliminate anyone in sight, for no reason! (I now wonder how any marriage can last through menopause if a woman doesnt have a way to counteract those side effects!) Things I always find so cute and sweet about my husband can make me flip out in a second if I dont take that pill. So you can understand why he, the boy, my co-workers, the world, and I would be scared at the thought of me not taking it, even though the Lupron should be out of my system. ...
Worried Mom and her son, Worried Brother, co-wrote this post. Worried Mom is an attorney who currently works in the non-profit area, and Worried Brother is employed in the pharmaceutical industry, with a background in chemistry. This piece is sourced in the scientific literature; click superscripted footnotes to follow links. For recent mainstream coverage about the potential harms…
February 2011: Took antibiotics. Went in CD3 for baseline US and BW. US was descent. No new cysts, just the same old gunky ones hanging around. Most of the BW came back normal. The big surprise was my FSH. I had it tested in Sept and it was 7. Now this month it was 37.3 This is crazy! My immune tests results came in. He said everything was normal except my natural killer cells were elevated. The treatment is intralipids before ovulation. This med needs to be given through an IV and is expensive. I am going to start this next month. I took a lupron trigger for the first time. He had me get bloodwork the next day. My LH went up to 41 and my P was 4. He said those numbers were great and meant that I ovulated. I did P+3 us and it seems that I may have actually ruptured my follicle which would be a huge victory. My ovary is covered in junk so it was hard for her to say 100%, but I did not see any obvious follicle like I always had in the past.....I am pleased that I made some progress this month. ...
Hi Sherri, I am new here too. I am sorry that you are going through all of this. I too had the same problem at the age of 14. I had a total of 5 laparoscopies for the endo and then ended up having to have one of my ovaries removed. I also went through the Lupron and none of it seemed to do any good. They would work for a little while and then I would be right back where I started. It has been 2 years ago now that I finally had a complete hysterectomy. That for me has been the only thing that has helped. I would suggest, if this is something you are interested in, talking to your doctor about that option. I have been lucky enough through this all that I was blessed with 2 beautiful daughters. I wish you the best of luck with this, I know how painful and frustrating this can be ...
I was wondering how many people here have had a hysterectomy after they were diagnoised with IC? I know a lot of people had a hysterectomy and then afterwards were diagnoised with IC or found out that they problems they were having were not related to their reproductive system and were actually IC after all. The reason I ask is because I know I have IC, PFD, VV, and endo. My dr has started me on a 6 month course of Lupron to try to calm down the endo. He did admit to me at my last
Nine people died Tuesday when a disgruntled employee opened fire at a Connecticut beer distributor, killing himself as police arrived. Allegedly, Omar Thornton was about to be fired for stealing beer, and had previously accused co-workers of racism-accusations that he says went unanswered by management. Mass shootings always make big headlines, but theyre only a small fraction of the murders committed each year.
Dr. Petrungaro graduated from Loyola University Dental School in 1986, and completed an independent study of Periodontics at the Welsh National Dental School in Wales, UK. He completed his residency in Periodontics and has a specialty certificate in addition to a Masters of Science degree in Periodontics from Northwestern University Dental School. He is the former Coordinator of Implantology, Graduate Department of Periodontics, Northwestern University Dental School. Dr. Petrungaro has been in private practice of Periodontics and Implantology since 1988, and holds a license in Illinois and Washington State.. He is a fellow of the International & American College of Dentists, and a Diplomate of the International Congress of Oral Implantologists. Dr. Petrungaro is recognized around the world for his diversified seminars and lectures on advanced periodontal, prosthetic and implant interrelationships, bone re-generation and esthetic tissue formation, the All-on-4®, All-on-6; 48 Hour Nano-Ceramic ...
In this same study, the following adverse reactions were reported in less than 5% of the patients on LUPRON.. Cardiovascular System-Angina, Cardiac arrhythmias, Myocardial infarction, Pulmonary emboli; Gastrointestinal System-Diarrhea, Dysphagia, Gastrointestinal bleeding, Gastrointestinal disturbance, Peptic ulcer, Rectal polyps; Endocrine System-Libido decrease, Thyroid enlargement; Musculoskeletal System-Joint pain; Central/Peripheral Nervous System-Anxiety, Blurred vision, Lethargy, Memory disorder, Mood swings, Nervousness, Numbness, Paresthesia, Peripheral neuropathy, Syncope/blackouts, Taste disorders; Respiratory System-Cough, Pleural rub, Pneumonia, Pulmonary fibrosis; Integumentary System-Carcinoma of skin/ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions; Urogenital System-Bladder spasms, Dysuria, Incontinence, Testicular pain, Urinary obstruction; Miscellaneous-Depression, Diabetes, Fatigue, Fever/chills, Hypoglycemia, Increased BUN, ...
We strongly advise that printouts should NOT be kept for any length of time, or for future reference as they can weird pregnancy symptoms and cravings become out of weird pregnancy symptoms and cravings. So she 20 week pregnancy symptoms me to name Hilda. All IF tx together with IVF pregnancy after lupron depot Healthcare); 10,000 Lifetime Max for infertility coverage-can be used for any infertility therapy. This all being mentioned, FertiliWhey is a near raw milk as any whey protein powder can get and gives immunoglobulins, lactoferrin and serum albumin, plus the co-factors and essential amino acids which can be immune and vitality enhancing. You can test out of the primary two years of college and save hundreds off your diploma. This leakage can lead to a bitter or sour style in the mouth. Visit Pay it Weird pregnancy symptoms and cravings Fertilitys Incessantly Requested Questions for more details about the grant and eligibility necessities. Fatigue, tiredness and exhaustion are really ...
The Translational Andrology and Urology provides current and practical information on basic research, diagnosis, prevention and clinical investigations of Andrology and Urology.
The Translational Andrology and Urology provides current and practical information on basic research, diagnosis, prevention and clinical investigations of Andrology and Urology.
Andrology is defined as the branches of science and medicine dealing with reproductive functions of the male under physiological and pathological conditions. This category contains journals providing information in the field of andrology.
I do so love to report these wins for reality, as rare as they are: the very vocal antivax advocate Mark Geier has had his medical license revoked in Maryland. Why?. The Maryland State Board of Physicians reviewed nine cases of autistic children seen by Geier, of which he treated seven. Of those nine, the Board found he misdiagnosed six of them. He (mis)diagnosed them with precocious puberty, a medical condition where kids have extremely early onset of puberty. Why would he do such a thing? Well, this condition can be treated with Lupron, a drug which lowers testosterone (its used to chemically castrate adult men). Geier happens to think Lupron can also help autism - despite there being no evidence at all thats the case - which makes his diagnosis very suspect. It implies strongly that he used the precocious puberty diagnosis as an excuse to prescribe the drug.. By the way, Lupron costs $5000 - $6000 a month to administer. The side effects can be severe as well, including seizures, and its ...
N. T. Tzvetkov, H. - G. Stammler, M. G. Georgieva, D. Russo, I. Faraone, A. A. Balacheva, S. Hristova, A. G. Atanasov, L. Milella, L. Antonov, et al., "Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.", European journal of medicinal chemistry, 2019, 179, :404-422 ...
Hubungi kantor Morinda kami untuk info Tahitian Noni, Maxidoid, Sugar stop, AGE Therapy gel wilayah Indonesia. mobile: 081242585758 pinBB 21E23235
Andrology is defined as the branches of science and medicine dealing with reproductive functions of the male under physiological and pathological conditions.
body { color: #000; background-color: #eee; font-size: smaller; font-family: Bitstream Vera Sans, Verdana, Arial, Lucida, Helvet +ica, sans-serif; } td, th { color: #000; font-size: smaller; font-family: Bitstream Vera Sans, Verdana, Arial, Lucida, Helvet +ica, sans-serif; } /* white page content */ td.main_content { background-color: #fff; } a:link { color: #036; } a:visited { color: #06c; } a.nnt-link:visited { color: #60f;} span.user-243505 {display:none; } /* hide im2 in OU list */ /* highlight specific users in OU */ .user-3607 a:link, .user-3607 a:visited, .user-22609 a:link, .user-22609 a:visited, .user-25047 a:link, .user-25047 a:visited, .user-108447 a:link, .user-108447 a:visited, .user-221638 a:link, .user-22168 a:visited, .user-272750 a:link, .user-272750 a:visited, .user-299049 a:link, .user-299049 a:visited, {color: #A00;} h3.other, h3.superdoc, h3.categorized_answer, h3.categorized_question { font-size: 28px; font-family: Georgia, serif; padding: 10px; } pre, tt { font-family: ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
The day before Cs egg retrieval, likely in the 2nd week of August, I will discontinue the Lupron and begin Progesterone injections. These injections are given in the bum, although I have been given permission to jab the needle into my upper thigh as well. Possible side-effects from progesterone can include bloating, weight gain and mood swings. These are the side-effects that scare me a bit; Ill needs lots of encouragement during this time, I think. Ill also begin the vagianl suppositories. I know, it sounds kinda icky...but after having 4 kids, Im not grossed out by "bodily" things much. This combination of hormones will continue until the 10th week of pregnancy ...
I have been thinking about what to do. Since lufs is my main problem. I would like to ignore the number and focus on using my good ovary and see how the Lupron and G-csf affect my LUFS. Statistically the right ovary goes more often than the left so this may be tricky. I may have to go back on stims to work them both. If nothing makes me rupture then I am done for good. Then if I do rupture but do not have success then I would consider having another surgery and get my ovary cleaned up. I have already had 5 and I really do not want to have another. I honestly do not know if my DH could take another one with the expense, travel, time off, emotions etc ...
After that, my IPs and I were in a race against the clock to get our contracts done because CCRM has a "holiday shutdown", which limits the availability they have for transfers. We literally got contracts done at the last possible minute!! Whew! So, CCRM sent us our calendar on Nov. 16th and weve been on the fast track ever since. I started Lupron on the 18th and then began estrace and vivelle patches on the 27th. Thankfully Ive had no side effects, as I have before. (Knock on wood!) It almost seems too good to be true! The only thing I dont really like are the vivelle patches and its only because the damn sticky crap stays on my skin and it also starts peeling and sticking to my clothes ...
Excess sugar is a very bad thing. In fact, sugar molecules are the building blocks of AGEs, harmful compounds that prematurely age the body. So if you want to stop AGEs, then youve got to stop sugar. Sugar Stop contains a proprietary blend of earths best ingredients designed to flush sugar out of your body before it is absorbed. In fact, with its new and improved formula, Sugar Stop now blocks the absorption of up to 60 percent of sugar consumed, 20 percent more than with our original formula! With its delicious carrot mango flavor, Sugar Stop goes great with any meal. Stop sugar, stop AGEs, and start living, looking and feeling younger, longer.. 8.19 oz per container. ...
Join our community. We offer 61 Products in our store. Fav-store specialize in supplying special featured herbal medecines, developed to improve your life and makes better your health. Sitemap page 49delhi no 1 andrology sexology doctor list.
Women living naturally is your online destination for information about HRT (Hormone Replacement Therapy), and alternative health remedies for menopause and PMS
Profile of Dr.N. Nagarajaiah, Urologist in Bangalore: Get complete information about Dr.N. Nagarajaiah MBBS, MS, Mch Urolog practicing at Shushrutha Urology And Andrology Clinic, his specialities, expertise with complete address, appointment phone numbers, timings, awards and associated hospital information | Sehat
cell junction, extracellular space, lysosome, cysteine-type endopeptidase activity, proteolysis involved in cellular protein catabolic process
Perform reliable qPCR with Bio-Rads pre-validated Testin primer pair, for the Rat genome. Designed for SYBR Green-based detection.
I took 10 IU of lupron for 21 days, starting on september 21st, then took two more days at 5 IU adding in 150 IU of follitism. I stopped all injections on the 14th. My last AF was 10/02, but Im not sure that matters so much after all the injections. I dont even know if Im supposed to ovulate. The doc says that af should start at the end of october, but to me this only seems possible if I ovulate by today, given a 14-day luteal phase, but then again, I dont know if I will ovulate because of the drugs!??? arrhhh! Im so lost ...
I finally got to talk with him about my colonoscopy. He said that the sigmoid portion of my colon was like a road with some road hazards. It was difficult to navigate the scope through, and, apparently very tense (as opposed to the rest that was relaxed?). This makes sense now, with the CT results back a few months ago that suggested colitis-it was all endometriosis causing the inflammation and "YUCKS". He biopsied all the places where there was indentation, and, thankfully it all came back negative. He said that at some point I might need a resection if problems resurface and worsen, but, nothing needs to be done now. Hopefully the Lupron will give my colon a break and some of those darned adhesions will "die" off. My care concerning this is turned over to my GYN, since the GI isnt really up on endo stuff. Theyve been amazing, and, Im thankful that I have someone to turn to if the need ever arises in the future. The whole practice is so warm and friendly, and so knowledgeable. Im SO glad ...
My nurse used to over-order for my TI cycles because insurance covered it but they wouldnt pay for IUI. Therefore, we had Bravelle left over when we moved on to IUI. Weve since used that up. Again, shes been over-ordering (I was using Bravelle (26 vials), Menopur (14 vials), Cetrotide (5 syringes), Novarel, Endrometrin (90 ct), Apri birth control, Norethindrone (20 tabs), and doxycycline (10 tabs). Total cost so far is around $3,223.I then added in a Lupron trigger that was $100. ) for IVF since its covered (we pay less than $4000 for everything). I only used about half of it for IVF #1. She ordered the same again this time. I could ask her to cut it down and pay even less, but I really, really hope to be able to donate my stockpile someday to someone that needs them since weve been so fortunate to pay so little.Willing to accept anything above $2000-$2700 for all ...
The big box containing $4,000 worth of medication arrived late last week. I started twice a day shots of Lupron on Sunday along with a five day prescription of Letrozole, which I had with each of my five IUIs. Im also on Dexamethasone every day until retrieval. Then Tuesday I added a shot of 375 units of Follistim, administered with a pen that you dial to get the correct dosage and a shot of one vial of Menopur, which you have to reconstitute before its ready to inject. Thank goodness for the educational CD that shows you exactly what to do. Id be lost without it. So thats four shots and two pills a day right now ...
OA Library offers high quality and most updated free academic thesis,open access resource covering various fields.It also provides Comprehensive Research Tool.
Buy Atarax (hydroxyzine) 25mg, 10mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
Ewing LL, Robaire B (1978). "Endogenous antispermatogenic agents: prospects for male contraception". Annu. Rev. Pharmacol. ... See also: List of investigational hormonal agents § Androgenics. Topical administration[edit]. There has been much interest and ... Srivastava RP, Bhaduri AP (1989). "Emerging concepts towards the development of contraceptive agents". Prog Drug Res. 33: 267- ... It was widely used, but has largely been abandoned for this indication in favor of newer agents with improved safety profiles ...
In any case, the drug is said to not be an effective antispermatogenic agent, whereas CPA is effective. Also unlike CPA, due to ... Cyproterone, which has·only weak antigonadotropic properties, was found to be a poor antispermatogenic agent (42). In contrast ... Ewing, L L; Robaire, B (1978). "Endogenous Antispermatogenic Agents: Prospects for Male Contraception". Annual Review of ... was found to be an antispermatogenic agent (142). Stewart, Mary Ellen; Pochi, Peter E. (1978). "ANTIANDROGENS AND THE SKIN". ...
... which in turn may improve its effectiveness as an antispermatogenic agent and male contraceptive. This is salient and ...
... contraceptive agents, male MeSH D27.505.696.875.360.443.068 --- antispermatogenic agents MeSH D27.505.696.875.360.443.068.760 ... contraceptive agents, male MeSH D27.505.954.705.360.443.068 --- antispermatogenic agents MeSH D27.505.954.705.360.443.068.760 ... antispermatogenic agents MeSH D27.505.696.138.379 --- sperm immobilizing agents MeSH D27.505.696.138.569 --- spermatocidal ... antispermatogenic agents MeSH D27.888.569.071.379 --- sperm immobilizing agents MeSH D27.888.569.071.569 --- spermatocidal ...
This results in increased potency and effectiveness of these AAS as antispermatogenic agents and male contraceptives (or, put ... Sjöqvist F, Garle M, Rane A (May 2008). "Use of doping agents, in particular anabolic steroids, in sports and society". Lancet ... The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose ... the effects of these agents have been divided into two partially dissociable types: anabolic (myotrophic) and androgenic.[1] ...
Pakrashi A, Pakrasi PL; Pakrasi (April 1977). "Antispermatogenic effect of the extract of Aristolochia indica Linn on male mice ... Kjaergaard N, Kjaergaard B, Lauritsen JG; Kjaergaard; Lauritsen (June 1988). "Prazosin, an adrenergic blocking agent inadequate ...
Antispermatogenic Agents. Physiological Effects of Drugs. Contraceptive Agents, Male. Contraceptive Agents. Reproductive ... Alkylating Agents. Molecular Mechanisms of Pharmacological Action. Antineoplastic Agents. Cathartics. Gastrointestinal Agents. ... Control Agents. Immunosuppressive Agents. Immunologic Factors. Antineoplastic Agents, Alkylating. ...
Reproductive Control Agents. Physiological Effects of Drugs. Spermatocidal Agents. Antispermatogenic Agents. Contraceptive ... C31G has been found to be a broad-spectrum antibacterial agent in vitro or in animals, active against both gram-positive and ...
Antihypertensive Agents. Antineoplastic Agents. Spermatocidal Agents. Antispermatogenic Agents. Contraceptive Agents, Female. ... Reproductive Control Agents. Antimutagenic Agents. Protective Agents. Anticarcinogenic Agents. Contraceptive Agents, Male. ... Sensory System Agents. Peripheral Nervous System Agents. ...
Ewing LL, Robaire B (1978). "Endogenous antispermatogenic agents: prospects for male contraception". Annu. Rev. Pharmacol. ... See also: List of investigational hormonal agents § Androgenics. Topical administration[edit]. There has been much interest and ... Srivastava RP, Bhaduri AP (1989). "Emerging concepts towards the development of contraceptive agents". Prog Drug Res. 33: 267- ... It was widely used, but has largely been abandoned for this indication in favor of newer agents with improved safety profiles ...
Contraceptive Agents. Reproductive Control Agents. Physiological Effects of Drugs. Spermatocidal Agents. Antispermatogenic ... Antineoplastic Agents. Protein Kinase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Agents targeting epidermal growth factor receptor (EGFR), matrix metalloproteinase, farnesyl transferase, protein kinase C and ...
development of antispermatogenic agents to suppress sperm production,. *prevention of sperm maturation, ...
In any case, the drug is said to not be an effective antispermatogenic agent, whereas CPA is effective. Also unlike CPA, due to ... Cyproterone, which has·only weak antigonadotropic properties, was found to be a poor antispermatogenic agent (42). In contrast ... Ewing, L L; Robaire, B (1978). "Endogenous Antispermatogenic Agents: Prospects for Male Contraception". Annual Review of ... was found to be an antispermatogenic agent (142). Stewart, Mary Ellen; Pochi, Peter E. (1978). "ANTIANDROGENS AND THE SKIN". ...
Blocking Agents, Sperm Maturation (0) see Antispermatogenic Agents. Blood Substitutes (6). Bone Cements (3) • Adhesives used to ... Bronchoconstrictor Effect (0) see Bronchoconstrictor Agents. Bronchodilator Agents (86) • Agents that cause an increase in the ... Bacteriocidal Agents (0) see Anti-Bacterial Agents. beta-Lactamase Inhibitors (24) • Endogenous substances and drugs that ... Bone Density Conservation Agents (45) • Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE ...
Contraceptive Agents. Reproductive Control Agents. Physiological Effects of Drugs. Spermatocidal Agents. Antispermatogenic ... Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of Pharmacological ... Patient must have recovered from all acute effects of previously administered investigational agents). ...
Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis Authors: Dolores D. Mruk, C. ...
Antispermatogenic Agents. Physiological Effects of Drugs. Contraceptive Agents, Male. Contraceptive Agents. Reproductive ... Anti-HIV Agents. Anti-Retroviral Agents. Antiviral Agents. Anti-Infective Agents. Cytochrome P-450 CYP3A Inhibitors. Cytochrome ...
A new class of antispermatogenic agents," Journal of Medicinal Chemistry, 1976, 19(6), 778-83. cited by other.. Powers-Martin ... agents having antithrombotic activity, agents lowering blood pressure,and agents altering lipid metabolism.. ... Agents which modify lipid metabolism preferably mean compounds from the group of CETP inhibitors, thyroid receptor agonists, ... Agents which lower blood pressure preferably mean compounds from the group of calcium antagonists, angiotensin AII antagonists ...
Cook, et al., "Structure-Activity Studies of 2,3,4,4a,5,9b-Hexahydroindenol[1,2-c]pyridines as Antispermatogenic Agents for ... 753-763, "Structure-Acitivity Studies of 2,3,4,4a,5,9b-Hexahydroindeno[1,2-c]Pyridines as Antispermatogenic Agents for Male ... Method for Determining Direct Effect of an Agent on Sperm Motility. The direct effect of an agent on sperm motility was ... Such an ideal male contraceptive agent is currently unavailable.. Some general cellular toxicants such as anticancer agents and ...
The antiviral agents, MAP30 and GAP31, are not toxic to human spermatozoa and may be useful in preventing the sexual ... Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats. J Ethnopharmacol 1998;61:9-16. View ... Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30. Anticancer Res ... the antiviral agent from bitter melon. Biochem Biophys Res Commun 1995;208:779-85. View abstract. ...
... which in turn may improve its effectiveness as an antispermatogenic agent and male contraceptive. This is salient and ...
2008): Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of ... The agent is water insoluble therefore for in vivo experiment, it was first dissolved in DMSO (Sigma, France) and then diluted ... Agents Actions 30: 393-402.. 28. Yu BZ, Rogers J, Ranadive G, et al. (1997): Gossypol modification of Ala-1 of secreted ... The effect of the agent is dependent on the dosage. As shown in Table 2, GA administered four times at the doses of 25 mg/kg ...
... contraceptive agents, male MeSH D27.505.696.875.360.443.068 --- antispermatogenic agents MeSH D27.505.696.875.360.443.068.760 ... contraceptive agents, male MeSH D27.505.954.705.360.443.068 --- antispermatogenic agents MeSH D27.505.954.705.360.443.068.760 ... antispermatogenic agents MeSH D27.505.696.138.379 --- sperm immobilizing agents MeSH D27.505.696.138.569 --- spermatocidal ... antispermatogenic agents MeSH D27.888.569.071.379 --- sperm immobilizing agents MeSH D27.888.569.071.569 --- spermatocidal ...
However, this seems largely untenable, based on the studies of men occupationally exposed to such agents (above), as it is ... effects of commonly prescribed drugs that are not necessarily considered as anti-spermatogenic. This is highlighted by a recent ... 1984). Similarly, some chemotherapeutic agents (anti-mitotics such as cyclophosphamide) used for treatment of cancers or of ... itself is directly vulnerable to adverse effects resulting from lifestyle of the man and/or his exposure to toxic agents from ...
... in mice diet which were considered to be anti-spermatogenic agents.. 1: Lumen of seminiferous tubules; 2: Spermatids; 3: Leydig ... Montanari, T., De Carvalho, J.E. and Dolder, H. (1998) Antispermatogenic Effect of Achillea millefolium L. in Mice. ...
Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria. ... The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma ... Used as a single agent, LND does not efficiently impede cancer cell growth, both in vitro and in vivo, being its effects ... The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane ...
Antispermatogenic agents (cytotoxic chemotherapies, colchicine, sulphasalazine, nitrofurantoin, amiodarone).. *Antimotility ...
Anti-spermatogenic agents (Cytotoxic chemotherapies, colchicine, sulphasalazine, Nitrofurantoin, Amiodarone). *Anti-motility ...
... was a limiting factor in the development of a male contraceptive regimen since all currently tested anti-spermatogenic agents ... The feasibility of a spacing method for contraception, using Styrene Maleic Anhydride (SMA) as a vas occlusive agent, has been ...
Lonidamine (50264-69-2) was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease ... 2002), Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids; Contraception, 65 277 ...
Antispermatogenic Agents. *Astringents. *Bone Density Conservation Agents. *Central Nervous System Depressants. *Central ...
  • Its antifertility characteristics are being explored as the possible starting point development of a new oral contraceptive agent which works by stimulating an evacuation of the implanted egg in the uterus. (healthy.net)
  • Also these results suggest that extracts prepared from the flowers of A. kellalensis may be potential anti-rotaviral agents in vivo and be useful in veterinary medicine. (jjnpp.com)
  • In the present study, we report synthesis of new coumarin derivatives as prospective therapeutic agents and investigate their antioxi-dant properties. (naukarus.com)
  • Rotaviruses are the major etiologic agents that cause severe, acute dehydrating gastroenteritis in young children and in a wide variety of domestic animals. (jjnpp.com)
  • present study is an attempt to determine the mode of action as anti-neoplastic agents and to evaluate the agents' acute toxicity in mice. (docme.ru)
  • Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)
  • The intraperitoneal administration of B. ciliata as a protective agent, produced significant increase in albumin levels with significant decrease in the levels of tumor markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alpha feto protein (AFP), gamma glutamyl transferase (Y-GT), 5 nucleotidase (5NT), glucose-6-phosphate dehydrogenase (G6PDH) and bilirubin. (bvsalud.org)
  • La prevención de alteraciones posturales y el control del sobrepeso y obesidad deben realizarse precozmente en todo el sistema educativo. (bvsalud.org)
  • Hypoglycemic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Agents targeting epidermal growth factor receptor (EGFR), matrix metalloproteinase, farnesyl transferase, protein kinase C and retinoic X receptor have so far shown no survival benefit in combination with chemotherapy in advanced NSCLC (5-10). (clinicaltrials.gov)
  • This graph shows the total number of publications written about "Hypoglycemic Agents" by people in this website by year, and whether "Hypoglycemic Agents" was a major or minor topic of these publications. (ucdenver.edu)