Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis.
A plant genus of the family FABACEAE that contains crotalarin.
A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.
An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
I'm sorry for any confusion, but "shorthand" is not a term that has a medical definition; it refers to a system of writing quickly by using abbreviations, symbols, or omissions of letters and sounds to represent words or phrases.
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

Testin induction: the role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat sertoli cells. (1/26)

Results of previous in vitro and in vivo studies have illustrated that the expression of testin by Sertoli cells is tightly associated with the disruption of Sertoli-germ cell junctions. In the present study, treatment of rats with cadmium chloride (CdCl(2)), which disrupted the inter-Sertoli tight junctions, failed to induce any changes in testicular testin expression. In contrast, lonidamine, an antispermatogenic drug that rearranges the Sertoli cell membrane microfilament structure causing a disruption of Sertoli-germ cell adhesion junctions, induced a drastic increase in testicular testin expression when administered orally. Lonidamine-induced Sertoli cell testin expression involved both ongoing RNA and de novo protein synthesis. Basal testin expression remained stable during the 27-h incubation with actinomycin D but required de novo protein synthesis in vitro. An inhibitor of protein kinase A, Rp-cAMPS, caused a 50% inhibition of Sertoli cell testin expression at 10 microM within 24 h. A biphasic response was noted in testin expression when forskolin was included in the Sertoli cell culture, and high concentrations of cAMP analogues (1 mM) rapidly reduced testin expression. However, lonidamine can abolish the inhibitory effect of cAMP analogues on Sertoli cell testin expression. These results illustrate that the induction of testin expression may involve several signal transduction pathways.  (+info)

The contribution of Asian scientists to global research in andrology. (2/26)

AIM: To present a personal account of the involvement of the World Health Organization (WHO) in the collaborative development in Asia of those areas of andrology concerned with male contraception and reproductive health. METHODS: The andrology training through workshops and institution support undertaken by the WHO Human Reproduction Programme (HRP) and how they contributed to the strengthening of andrology research in Asia are summarised. RESULTS: The author' s experience and the Asian scientific contributions to the global research in the following areas are reviewed: the safety of vasectomy and the development of new methods of vas occlusion; gossypol and its failure to become a safe, reversible male antifertility drug; Tripterygium and whether its pure extracts will pass through the appropriate toxicology and phased clinical studies to become acceptable contraceptive drugs; hormonal methods of contraception for men. CONCLUSION: The WHO policy of research capacity building through training and institution strengthening, together with the collaboration of Asian andrologists, has created strong National institutions now able to direct their own programmes of research in clinical and scientific andrology.  (+info)

Hormonal contraception in the male. (3/26)

The hormonal approach to male contraception is based on the suppression of gonadotrophin secretion with secondary suppression of spermatogenesis. This can be achieved by administration of testosterone or other androgen alone, but combined administration with a progestogen or GnRH analogue allows the dose of testosterone to be reduced to physiological replacement doses. This approach has been investigated for many years but without identification of a regimen which results in sufficient suppression of spermatogenesis to provide ensured contraception in all men, safely and conveniently. The reasons for this are discussed, and recent developments towards a regimen that fulfills all these criteria are described. Crucial to development of any new product is that it will be used: surveys of both men and women indicate firmly positive attitudes towards a 'male pill'. There are, therefore, grounds for cautious optimism that the next decade may see the introduction of the first novel male contraceptive for several hundred years.  (+info)

Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. (4/26)

The oral male contraceptive agent 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide (AF2364) is a new analogue of indazole-carboxylic acid. AF2364 was orally administered to rats at 50 mg/kg body weight once weekly for five consecutive weeks. The effects on fertility efficacy, hormonal profile, organ weights, tissue morphology, and serum microchemistry were examined. Complete infertility was noted in rats 29 days after the initial dose of AF2364 and continued until 90 days. Fertility resumed in 25% of the group after 104 days and had resumed in 75% of the rats by the last mating at 197 days. Morphological examination of the testis showed rapid exfoliation of elongated spermatids and the generation of large multinucleated cells 6 days after the first treatment, with depletion of most germ cells after 40 days. Normal spermatogenesis was noted in 95% of the tubules in the animals that were fertile at 210 days. Morphological analysis of the epididymal compartments revealed reduced lumen size, whereas the prostate exhibited an increase in the glandular lumen with a reduction in epithelium height. No morphological changes were detected in the kidney, liver, and cerebrum by light microscopy. Kidney and liver function, as evaluated by serum chemistry, were not affected by the drug treatment. AF2364 did not alter the levels of FSH, and only minimal changes were noted for LH and testosterone, suggesting that the hypothalamic-pituitary-testicular axis was not affected. These results illustrate the potential of AF2364 as a male contraceptive.  (+info)

Lupron depot prevention of antispermatogenic/antifertility activity of the indenopyridine, CDB-4022, in the rat. (5/26)

The goals of this study were to determine the CDB-4022 dose-response relationship for induction of acute decreases in testicular weight and germ cell depopulation in rats; establish the threshold dose of CDB-4022 required to induce infertility; and investigate whether CDB-4022-induced testicular damage could be prevented by a GnRH agonist (Lupron Depot). Reduction of testis weight and germ cell depopulation were observed 7 days after a single oral dose of 1 mg CDB-4022/kg, whereas 0.5 mg/kg had no observable effect. These effects were maximal at 12.5 or 25 mg CDB-4022/kg. After a single oral dose of either 2.5 or 5 mg/kg, CDB-4022 induced infertility in five of five treated rats by Week 5, whereas only one of five males was rendered infertile at a dose of 1 mg/kg. Proven fertile male rats (6/group) were treated with vehicle, CDB-4022 alone (2.5 mg/kg on Day 0), CDB-4022 plus Lupron Depot (on Weeks -1, 2, 5, and 8), or Lupron Depot alone. Control males demonstrated normal fertility throughout a 32-wk cohabitation period. Five of six rats were rendered transiently infertile with Lupron Depot alone, but all recovered fertility. CDB-4022 treatment resulted in infertility in all six rats, and only one of six regained fertility. Combined treatment also caused infertility in all six rats, but four of six recovered fertility (P = 0.08 compared to CDB-4022 alone). Testicular weight was decreased in the three treatment groups compared to vehicle controls; testicular weights were ranked from highest to lowest as follows: vehicle > Lupron Depot > Lupron Depot + CDB-4022 > CDB-4022. The tubule differentiation index of Lupron Depot-treated rats (96 +/- 4%) was not different from vehicle-treated rats (100%). CDB-4022 treatment decreased the number of differentiating tubules (15 +/- 8%). Lupron Depot plus CDB-4022 treatment resulted in a greater number of differentiating tubules (53 +/- 12%) than CDB-4022 alone, but this was still lower than vehicle- or Lupron Depot-treated rats. These data indicate that 2.5 mg/kg of CDB-4022 was the oral threshold dose that caused testicular damage rendering the majority of adult male rats permanently infertile within the study interval; 12.5 mg/kg of CDB-4022 induced maximal testicular damage. Suppression of gonadotropins and/or testosterone production by treatment with Lupron Depot before and after CDB-4022 prevented the CDB-4022-induced irreversible testicular damage.  (+info)

Expression of the cystic fibrosis transmembrane conductance regulator in rat spermatids: implication for the site of action of antispermatogenic agents. (6/26)

To establish whether cystic fibrosis transmembrane conductance regulator (CFTR) is functionally expressed in the testis, we subjected spermatogenic cells from rat testes to analysis of CFTR mRNA, protein and channel activity. CFTR mRNA was detected in the testes of mature but not immature rats using reverse transcription-polymerase chain reaction analysis. Western blot analysis performed with a CFTR specific antibody revealed immunoreactivity in the membrane extract of spermatogenic cells. Immunohistochemical studies localized CFTR in round and elongated spermatids, but not in the fully developed spermatozoa. Using a whole-cell patch clamp technique, we recorded an inward current activated by intracellular cAMP (100 micromol/l) in round spermatids. The current displayed a linear I / V relationship and was inhibited by diphenylamine-2-carboxylate (DPC), a chloride channel blocker. Transfection of the rat germ cell CFTR cDNA into human embryonic kidney (HEK) 293 cells caused the expression of a cAMP-activated chloride current with CFTR characteristics. The current was completely blocked by the antispermatogenic agents 1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid, lonidamine (500 micromol/l) and 1-(2,4-dichlorobenzyl)-indazole-3-acrylic acid, AF2785 (250 micromol/l). These results taken together provide evidence that CFTR is differentially expressed in spermatids during spermiogenesis. We speculate that CFTR may interact with aquaporin to bring about cytoplasmic volume contraction which is an essential feature of spermiogenesis.  (+info)

Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats. (7/26)

The present studies were undertaken to determine the testicular cell type(s) affected by the antispermatogenic indenopyridine CDB-4022. At the oral threshold dose (2.5 mg/kg), CDB-4022 induced infertility in all males. CDB-4022 did not alter (P > 0.05) Leydig cell function as assessed by circulating testosterone, seminal vesicle, and ventral prostate weights or body weight gain compared to controls. Conversely, CDB-4022 reduced (P < 0.05) testicular weight, spermatid head counts, and percentage of seminiferous tubules undergoing spermatogenesis. In a second study, adult male rats received a maximally effective oral dose of CDB-4022 (12.5 mg/kg), dipentylphthalate (DPP; 2200 mg/kg; a Sertoli cell toxicant), or vehicle and were necropsied 3, 6, or 12 h after dosing to determine acute effects. Serum inhibin B levels were suppressed (P < 0.05) by 6 h after CDB-4022 or DPP treatment, but epididymal androgen-binding protein (ABP) levels were not altered (P > 0.05), compared to controls. CDB-4022 and DPP increased (P < 0.05) the percentage of tubules with apoptotic germ cells, particularly differentiating spermatogonia and spermatocytes, by 12 h after dosing. Microscopic examination of the testis indicated a greater degree of vacuolation in Sertoli cells and initial signs of apical germ cell sloughing/shedding by 3 or 12 h after CDB-4022 or DPP treatment, respectively. In a third study, prepubertal male rats were treated with vehicle, 12.5 mg/kg of CDB-4022, or 2200 mg/kg of DPP, and the efferent ducts of the right testis were ligated 23 h before necropsy. Seminiferous tubule fluid secretion (difference in weight of testes), serum inhibin B levels, and ABP levels in the unligated epididymis were reduced (P < 0.05) at 24 and 48 h after dosing in CDB-4022- and DPP-treated rats compared to controls. Collectively, these data suggest that CDB-4022 disrupts spermatogenesis by inducing apoptosis in early stage germ cells via a direct action on the Sertoli cell.  (+info)

Rabbit epididymal secretory proteins. II. Immunolocalization and sperm association of REP38. (8/26)

Polyclonal antibody was used to partially characterize REP38, a major rabbit epididymal secretory protein. Western blot analyses and immunohistochemistry indicated that REP38 is only expressed in regions 5 and 6 of the epididymis (corpus epididy-midis) and is localized in the supranuclear region and microvilli of the principal cells in these regions. It was not expressed in other tissues of the body. In region 8 (cauda epididymidis), REP38 was detected in the luminal border and cytoplasm of scattered principal cells, indicating that it may be reabsorbed in this region. This protein accumulated on the sperm plasma membrane downstream of region 5 and was localized predominantly over the acrosomal and postacrosomal regions of the head and the middle piece. Although tightly bound to epididymal sperm, REP38 migrated to the equatorial segment under conditions in vivo that would promote capacitation. When tested in vitro, anti-REP38 IgG reduced the percentage of ova fertilized in a concentration-dependent manner, apparently by blocking sperm-egg fusion.  (+info)

Antispermatogenic agents are substances or drugs that inhibit or prevent the production of sperm in the testes. These agents can work by various mechanisms, such as interfering with the formation and maturation of sperm cells, damaging sperm DNA, or suppressing the hormones responsible for sperm production.

Examples of antispermatogenic agents include chemotherapy drugs, radiation therapy, and certain medications used to treat prostate cancer or other conditions. Prolonged use of these agents can lead to infertility, so they are often used with caution and only when necessary. It is important to note that the use of antispermatogenic agents should be under the guidance and supervision of a medical professional.

'Crotalaria' is a genus of flowering plants in the family Fabaceae, also known as the pea or legume family. These plants are commonly known as rattleboxes due to the seeds that rattle inside their swollen, inflated pods. The plants are native to tropical and warm temperate regions around the world and contain several species that can be found in various environments such as grasslands, savannas, and disturbed areas.

While 'Crotalaria' itself is not a medical term, some species of this plant genus have been reported to contain pyrrolizidine alkaloids (PAs), which can be toxic to humans and animals if ingested. These toxins can cause liver damage and other health issues in severe cases. However, it's important to note that not all Crotalaria species produce PAs, and the toxicity levels may vary depending on the specific species and individual sensitivity.

In summary, 'Crotalaria' is a genus of flowering plants with some species containing potentially toxic pyrrolizidine alkaloids. While it is not a medical term itself, it has implications for human and animal health due to the presence of these toxins in certain species.

I'm sorry for any confusion, but "Indenes" is not a recognized medical term or concept in the field of medicine or healthcare. It may be that there is a spelling mistake or typo in your question. If you are referring to "Indenes" as a chemical compound, it is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C9H8. However, I would recommend consulting a chemistry or toxicology resource for information on its non-medical uses and properties.

Cyproterone acetate is a synthetic steroid hormone with anti-androgen and progestogenic properties. It works by blocking the action of androgens (male sex hormones) in the body, which helps to reduce symptoms associated with excessive androgen production such as severe acne or hirsutism (excessive hair growth).

Cyproterone acetate is used in the treatment of conditions such as prostate cancer, where it can help to slow the growth of cancer cells by reducing the levels of androgens in the body. It is also used in the treatment of sexual deviations, such as pedophilia or exhibitionism, as it can reduce sexual desire.

In addition, cyproterone acetate is sometimes used in combination with estrogen in hormone replacement therapy for transgender women to suppress the production of testosterone and promote feminization.

It's important to note that cyproterone acetate can have significant side effects and its use should be under the close supervision of a healthcare professional.

Cyproterone is an anti-androgen medication that works by blocking the action of androgens (male hormones such as testosterone) in the body. It is used to treat conditions such as prostate cancer, hirsutism (excessive hair growth), and severe acne that have not responded to other treatments. Cyproterone is also used in conjunction with estrogen therapy to help reduce sexual desire in individuals with paraphilic disorders or gender identity disorder.

The medication comes in the form of tablets and is usually taken once or twice a day, depending on the condition being treated. Common side effects of cyproterone include breast tenderness, decreased sex drive, and irregular menstrual periods. More serious side effects may include liver damage, blood clots, and an increased risk of certain types of cancer.

It is important to follow the instructions of a healthcare provider when taking cyproterone, as the medication can interact with other medications and have potentially serious side effects. Regular monitoring by a healthcare provider is also necessary to ensure that the medication is working effectively and to monitor for any potential side effects.

I'm sorry for any confusion, but "shorthand" is not a medical term. It refers to a system of writing quickly by using abbreviations or symbols to represent words, sounds, or phrases. This skill is often used in secretarial work and journalism to take notes or transcribe speech rapidly. If you have any medical terms you'd like me to define, I'd be happy to help!

Androgen antagonists are a class of drugs that block the action of androgens, which are hormones that contribute to male sexual development and characteristics. They work by binding to androgen receptors in cells, preventing the natural androgens from attaching and exerting their effects. This can be useful in treating conditions that are caused or worsened by androgens, such as prostate cancer, hirsutism (excessive hair growth in women), and acne. Examples of androgen antagonists include flutamide, bicalutamide, and spironolactone.

Chlormadinone Acetate is a synthetic progestin, which is a type of female sex hormone. It is used in the treatment of various medical conditions such as endometriosis, uterine fibroids, and abnormal menstrual bleeding. It works by suppressing the natural progesterone produced by the ovaries, thereby preventing the buildup of the lining of the uterus (endometrium). This medication is available in the form of tablets for oral administration.

It's important to note that Chlormadinone Acetate can cause a range of side effects and should only be used under the supervision of a healthcare provider. Additionally, it may interact with other medications, so it's important to inform your doctor about all the medications you are taking before starting this medication.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Ethinyl estradiol is a synthetic form of the hormone estrogen that is often used in various forms of hormonal contraception, such as birth control pills. It works by preventing ovulation and thickening cervical mucus to make it more difficult for sperm to reach the egg. Ethinyl estradiol may also be used in combination with other hormones to treat menopausal symptoms or hormonal disorders.

It is important to note that while ethinyl estradiol can be an effective form of hormonal therapy, it can also carry risks and side effects, such as an increased risk of blood clots, stroke, and breast cancer. As with any medication, it should only be used under the guidance and supervision of a healthcare provider.

"Antispermatogenic Agents" by people in Harvard Catalyst Profiles by year, and whether "Antispermatogenic Agents" was a major or ... "Antispermatogenic Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Antispermatogenic Agents" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Antispermatogenic Agents". ...
In any case, the medication is said to not be an effective antispermatogenic agent, whereas CPA is effective. Also unlike CPA, ... Cyproterone, which has·only weak antigonadotropic properties, was found to be a poor antispermatogenic agent (42). In contrast ... Ewing LL, Robaire B (1978). "Endogenous antispermatogenic agents: prospects for male contraception". Annual Review of ... was found to be an antispermatogenic agent (142). Stewart ME, Pochi PE (April 1978). "Antiandrogens and the skin". ...
medicinal agent, a preservative, and in perfumery. Whole Peppercorn of Piper nigrum or its active components are being used in ... anti-metastatic, antimutagenic, anti-spermatogenic, anti-Colon toxin, anti-asthmatics, anti-anxiety, antithyroids, antifungal, ... Essential oils of black pepper are used as preservative agents for different food packaging as well as used in perfumes due to ... apoptotic, anti-metastatic, antimutagenic, anti-spermatogenic, anti-. Colon toxin, insecticidal and larvicidal activities etc. ...
Antispermatogenic Agents. Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block ... The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or ... Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the ... Spermatogenesis-Blocking Agents. Chemical substances which inhibit the process of spermatozoa formation at either the first ...
... antifertility and antispermatogenic agent. Aristolochic acid, a major active constituent of the plant is reported to cause ...
Characterization of the exfoliative antispermatogenic agent 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid in the rhesus ... Electron microscope study of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid, an exfoliative antispermatogenic agent, in ...
There is growing concern on the use of oral hypoglycemic agents (OHAs) during pregnancy, due to the potential of the agents in ... Background: Quinine has been reported to possess anti-spermatogenic activities. Objectives: This study was carried out to ... The oral hypoglycemic agents are less invasive, improve patients compliance, which can be effective in maintaining the blood ... The oral hypoglycemic agents are less invasive, improve patients compliance, which can be effective in maintaining the blood ...
Antispermatogenic Agents. *Astringents. *Bone Density Conservation Agents. *Central Nervous System Depressants. *Central ... "Protective Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Bernhardt SM, Borges VF, Schedin P. Vitamin D as a Potential Preventive Agent For Young Womens Breast Cancer. Cancer Prev Res ... This graph shows the total number of publications written about "Protective Agents" by people in this website by year, and ...
Antispermatogenic Agents [D27.505.696.138] * Astringents [D27.505.696.207] * Bone Density Conservation Agents [D27.505.696.242] ... Opioid Reversal Agents Related Concept UI. M000640784. Registry Number. 0. Terms. Opioid Reversal Agents Preferred Term Term UI ... Opioid Reversal Agent Opioid Reversal Agents Registry Number. 0. NLM Classification #. QV 89. Date Established. 1966/01/01. ... Peripheral Nervous System Agents [D27.505.696.663] * Sensory System Agents [D27.505.696.663.850] * Abuse-Deterrent Formulations ...
Antispermatogenic Agents [D27.505.696.138] Antispermatogenic Agents * Astringents [D27.505.696.207] Astringents * Bone Density ...
Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites ... from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE ...
Antispermatogenic Agents. *Astringents. *Bone Density Conservation Agents. *Central Nervous System Depressants. *Central ... "Peripheral Nervous System Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Peripheral Nervous System Agents" by people in this website by ... Below are the most recent publications written about "Peripheral Nervous System Agents" by people in Profiles. ...
Antispermatogenic Agents. *Astringents. *Bone Density Conservation Agents. *Central Nervous System Depressants. *Central ...
"Cytostatic Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cytostatic Agents" by people in this website by year, and ... Below are the most recent publications written about "Cytostatic Agents" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Cytostatic Agents". ...
Antispermatogenic Agents. *Astringents. *Bone Density Conservation Agents. *Central Nervous System Depressants. *Central ...
Antispermatogenic Agents [D27.505.696.138] * Astringents [D27.505.696.207] * Bone Density Conservation Agents [D27.505.696.242] ... Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. ... Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. ...
Antispermatogenic and antifertility effects of 20,25-diazacholesterol dihydrochloride in mice. Singh, Shio K; Chakravarty, ... In this study, we first sought to investigate the testicular toxicity of different apoptosis-inducing agents. We next ... Our results thus suggest that SC 12937 treatment causes antispermatogenic and antifertility effects in P mice and that the ... a hypocholesterolemic agent, on the testis of Parkes (P) strain mice was investigated. Histologically, testes in mice treated ...
Thus, importance of Cannabis is mostly described as a narcotic analgesic agent. But, the impacts of Cannabis on the ... Singh SK, Chakravarty S. Antispermatogenic and antifertility effects of 20, 25-diazacholesterol dihydrochloride in mice. Reprod ...
Biological & Chemicals Agents on U. S. Citizens is Illegal! Get active! Where to call to complain about Chemtrail spraying in ... Spraying Biological & Chemicals Agents on U. S. Citizens is Illegal! The only way to STOP CHEMTRAILS is to wake up others! ... Antispermatogenic effects have been demonstrated in various animal species. Ethylene dibromide is included in Reproductive and ...
In some countries leaves and young shoots are used as flavouring agents. The leaves can also be cooked and eaten as leafy ... Bitter gourd has anti-spermatogenic, abortifacient and fertility reducing properties.. .resp-1{width:320px;height:250px}@media( ...
Generally, this unique wound healing plant can be classified among agents with low toxicity [66]. In an in vivo study by Okokon ... O. R. Asuquo, M. A Eluwa, and O. E. Mesembe, "Antispermatogenic activity of Aspilia africana methanol leaf extract in male ... R. Reifen, A. Karlinsky, A. H. Stark, Z. Berkovich, and A. Nyska, "α-Linolenic acid (ALA) is an anti-inflammatory agent in ... These findings further showed that the anti-inflammatory and antimicrobial agent play vital roles in wound healing process. ...
anti-fertility agent and libido enhancer in Ayurveda, Holy Basil (also known as Tulsi) is currently being investigated for ... Seth SD, Johri N, Sundaram KRAntispermatogenic effect of Ocimum sanctumIndian J Exp Biol. .. (. 1981 Oct. ). ...
  • This graph shows the total number of publications written about "Antispermatogenic Agents" by people in Harvard Catalyst Profiles by year, and whether "Antispermatogenic Agents" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Antispermatogenic Agents" by people in Profiles. (harvard.edu)
  • Below are the most recent publications written about "Peripheral Nervous System Agents" by people in Profiles. (uchicago.edu)
  • Antispermatogenic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Peripheral Nervous System Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Agents inhibiting the effect of narcotics on the central nervous system. (nih.gov)
  • Agents that have a damaging effect on the HEART. (musc.edu)
  • Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis. (harvard.edu)
  • Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. (nih.gov)
  • Much of the Institute's research on contraceptive agents and their evaluation is done through the Contraceptive Discovery and Development Branch (CDDB) . (nih.gov)
  • The possibility of overdose and misappropriation in the usage of antimalarial agents are very common, all of which could lead to toxic effects of the drugs 7, 8 . (ijpsr.com)
  • As with any new pharmaceutical agent, a complete understanding of the long-term effects will not be possible until Phase IV postmarketing data can be collected. (medscape.com)
  • Consequently, it is essential that sensitive criteria be used to look for effects on a multiplicity of target sites when an agent is evaluated using an animal model. (nih.gov)
  • Cytostatic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Agents, either mechanical or chemical, which destroy spermatozoa in the male genitalia and block spermatogenesis. (nih.gov)
  • The potential impact of an agent altering male reproductive function is greater for humans than for animals. (nih.gov)
  • Our research has demonstrated that Macaranga barteri extracts has potent antiviral activity against echoviruses E7 and E19, and our findings suggest that this extract may have potential as a therapeutic agent in the treatment of enteroviral infections. (biomedcentral.com)
  • This is due to the development of resistance of parasite to mainly antimalarial agents 4, 5 resulting in huge impact on the socio-economy 6 . (ijpsr.com)
  • Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells. (harvard.edu)