Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Seven membered heterocyclic rings containing a NITROGEN atom.
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The deliberate and methodical practice of finding new applications for existing drugs.
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
The condition of being heterozygous for hemoglobin S.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Infections with bacteria of the genus PSEUDOMONAS.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.
A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Agents used to prevent the formation of foam or to treat flatulence or bloat.
Substances added to foods and medicine to improve the quality of taste.
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
A plant genus of the family POACEAE.
A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.
PASSERIFORMES of the suborder, Oscines, in which the flexor tendons of the toes are separate, and the lower syrinx has 4 to 9 pairs of tensor muscles inserted at both ends of the tracheal half rings. They include many commonly recognized birds such as CROWS; FINCHES; robins; SPARROWS; and SWALLOWS.
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. (1/147)

1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore A23187 (2 microM) to rabbit red cells suspended at a haematocrit of 1% in a low potassium solution ([K]0 0.12-0.17 mM) at 37 degrees C. Net movement of K+ was measured using a K+-sensitive electrode placed in the suspension. 3. The concentrations (microM +/- s.d.) of the compounds tested causing 50% inhibition of K+ loss were: quinine, 37 +/- 3; cetiedil, 26 +/- 1; the cetiedil congeners UCL 1269, UCL 1274 and UCL 1495, approximately 150, 8.2 +/- 0.1, 0.92 +/- 0.03 respectively; clotrimazole, 1.2 +/- 0.1; nitrendipine, 3.6 +/- 0.5 and charybdotoxin, 0.015 +/- 0.002. 4. The characteristics of the block suggested that compounds could be placed in two groups. For one set (quinine, cetiedil, and the UCL congeners), the concentration-inhibition curves were steeper (Hill coefficient, nH, > or = 2.7) than for the other (clotrimazole, nitrendipine, charybdotoxin) for which nH approximately 1. 5. Compounds in the first set alone became less active on raising the concentration of K+ in the external solution to 5.4 mM. 6. The rate of K+ loss induced by A23187 slowed in the presence of high concentrations of cetiedil and its analogues, suggesting a use-dependent component to the inhibitory action. This was not seen with clotrimazole. 7. The blocking action of the cetiedil analogue UCL 1274 could not be overcome by an increase in external Ca2+ and its potency was unaltered when K+ loss was induced by the application of Pb2+ (10 microM) rather than by A23187. 8. These results, taken with the findings of others, suggest that agents that block the red cell Ca2+-activated K+ permeability can be placed in two groups with different mechanisms of action. The differences can be explained by supposing that clotrimazole and charybdotoxin act at the outer face of the channel whereas cetiedil and its congeners may block within it, either at or near the K+ binding site that determines the flow of K+.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/147)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/147)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Persistent respiratory effects in survivors of the Bhopal disaster. (4/147)

OBJECTIVE: To examine the role of exposure to the 1984 Bhopal gas leak in the development of persistent obstructive airways disease. DESIGN: Cross sectional survey. SETTING: Bhopal, India. SUBJECTS: Random sample of 454 adults stratified by distance of residence from the Union Carbide plant. MAIN OUTCOME MEASURES: Self reported respiratory symptoms; indices of lung function measured by simple spirometry and adjusted for age, sex, and height according to Indian derived regression equations. RESULTS: Respiratory symptoms were significantly more common and lung function (percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), and FEV1/FEV ratio) was reduced among those reporting exposure to the gas leak. The frequency of symptoms fell as exposure decreased (as estimated by distance lived from the plant), and lung function measurements displayed similar trends. These findings were not wholly accounted for by confounding by smoking or literacy, a measure of socioeconomic status. Lung function measurements were consistently lower in those reporting symptoms. CONCLUSION: Our results suggest that persistent small airways obstruction among survivors of the 1984 disaster may be attributed to gas exposure.  (+info)

The reaction of deoxy-sickle cell hemoglobin with hydroxyurea. (5/147)

In addition to its capacity to increase fetal hemoglobin levels, other mechanisms are implicated in hydroxyurea's ability to provide beneficial effects to patients with sickle cell disease. We hypothesize that the reaction of hemoglobin with hydroxyurea may play a role. It is shown that hydroxyurea reacts with deoxy-sickle cell hemoglobin (Hb) to form methemoglobin (metHb) and nitrosyl hemoglobin (HbNO). The products of the reaction as well as the kinetics are followed by absorption spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. Analysis of the kinetics shows that the reaction can be approximated by a pseudo-first order rate constant of 3.7x10(-4) (1/(s.M)) for the disappearance of deoxy-sickle cell hemoglobin. Further analysis shows that HbNO is formed at an observed average rate of 5.25x10(-5) (1/s), three to four times slower than the rate of formation of metHb. EPR spectroscopy is used to show that the formation of HbNO involves the specific transfer of NO from the NHOH group of hydroxyurea. The potential importance of this reaction is discussed in the context of metHb and HbNO being able to increase the delay time for sickle cell hemoglobin polymerization and HbNO's vasodilating capabilities through conversion to S-nitrosohemoglobin.  (+info)

Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. (6/147)

Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this agent in pediatric patients with sickle cell anemia has not been determined. Children with sickle cell anemia, age 5 to 15 years, were eligible for this multicenter Phase I/II trial. HU was started at 15 mg/kg/d and escalated to 30 mg/kg/d unless the patient experienced laboratory toxicity. Patients were monitored by 2-week visits to assess compliance, toxicity, clinical adverse events, growth parameters, and laboratory efficacy associated with HU treatment. Eighty-four children were enrolled between December 1994 and March 1996. Sixty-eight children reached maximum tolerated dose (MTD) and 52 were treated at MTD for 1 year. Significant hematologic changes included increases in hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, and fetal hemoglobin parameters, and decreases in white blood cell, neutrophil, platelet, and reticulocyte counts. Laboratory toxicities typically were mild, transient, and were reversible upon temporary discontinuation of HU. No life-threatening clinical adverse events occurred and no child experienced growth failure. This Phase I/II trial shows that HU therapy is safe for children with sickle cell anemia when treatment was directed by a pediatric hematologist. HU in children induces similar laboratory changes as in adults. Phase III trials to determine if HU can prevent chronic organ damage in children with sickle cell anemia are warranted.  (+info)

Acetylation of human hemoglobin by methyl acetylphosphate. Evidence of broad regio-selectivity revealed by NMR studies. (7/147)

The development of chemical modification agents that reduce the tendency of sickle hemoglobin (HbS) to aggregate represents an important chemotherapeutic goal. Methyl acetylphosphate (MAP) has been reported to bind to the 2,3-diphosphoglycerate (2,3-DPG) binding site of hemoglobin, where it selectively acetylates residues, resulting in increased solubility of HbS. We have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC and HSQC NMR studies. These spectra of the acetylated hemoglobin adducts showed 10-11 well resolved adduct peaks, indicating that the acetylation was not highly residue specific. The chemical shift pattern observed is in general similar to that obtained recently using [1'-(13)C]aspirin as the acetylating agent (Xu, A. S. L., Macdonald, J. M., Labotka, R. J., and London, R. E. (1999) Biochim. Biophys. Acta 1432, 333-349). Blocking the 2, 3-DPG binding site with inositol hexaphosphate (IHP) resulted in a selective reduction in intensity of adduct resonances, presumably corresponding to residues located in the 2,3-DPG binding cleft. The pattern of residue protection appeared to be identical to that observed in our previous study using IHP and labeled aspirin. Pre-acetylation of hemoglobin using unlabeled MAP, followed by acetylation with [1'-(13)C]aspirin indicated a general protective effect, with the greatest reduction of intensity for resonances corresponding to acetylated residues in the 2,3-DPG binding site. These studies indicated that both MAP and aspirin exhibit similar, although not identical, acetylation profiles and target primarily the betaLys-82 residue in the 2,3-DPG binding site, as well as sites such as betaLys-59 and alphaLys-90, which are not located in the beta-cleft of hemoglobin.  (+info)

Preliminary report of a toxicity study of hydroxyurea in sickle cell disease. French Study Group on Sickle Cell Disease. (8/147)

AIM: To evaluate the tolerance of hydroxyurea in children affected with sickle cell disease. DESIGN: Questionnaire study of French physicians likely to treat patients with sickle cell disease. Data were collected on 101 children with sickle cell disease, treated for a median of 22 months, 36 of whom were treated for more than three years. 13 children were younger than 5 years of age at inclusion. RESULTS: Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus. Acute lymphoblastic leukaemia occurred in a girl treated for 1.5 months with hydroxyurea, this short interval arguing against a causative association. One 17 year old boy had paraparesis after 8 years of treatment. CONCLUSIONS: No major short or medium term toxicity was related to hydroxyurea in this cohort of 101 children. However, the number of children treated for more than 3 years is too few to make firm conclusions on the long term tolerance of this drug.  (+info)

Abstract: The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries (LMICs).. This paper outlines conceptual frameworks of three primary stroke prevention strategies: (a) the polypill strategy; (b) a population-wide strategy; and (c) a motivational population-wide strategy.. (a) A polypill containing generic low-dose ingredients of blood pressure and lipid-lowering medications (e.g. candesartan 16 mg, amlodipine 2.5 mg, and rosuvastatin 10 mg) seems a safe and cost-effective approach for primary prevention of stroke and dementia.. (b) A population-wide strategy reducing cardiovascular risk factors in the whole population, regardless of the level of risk is the most effective primary prevention strategy. A motivational population-wide strategy for the modification of health behaviors (e.g. smoking, ...
TY - JOUR. T1 - Clinical research in primary stroke prevention. T2 - Needs, opportunities, and challenges. AU - Radziszewska, Barbara. AU - Hart, Robert G.. AU - Wolf, Philip A.. AU - DAgostino, Ralph B.. AU - Cutler, Jeffrey A.. AU - Broderick, Joseph P.. AU - Coull, Bruce M.. AU - Cushman, Mary. AU - DAgostino, Ralph B.. AU - Easton, Donald J.. AU - Einhorn, Paula. AU - Goldstein, Larry B.. AU - Gorelick, Philip B.. AU - Haffner, Steven. AU - Howard, George. AU - Johnston, S. Claiborne. AU - Kernan, Walter. AU - Longstreth, Will. AU - Pandey, Dilip K.. AU - Polak, Joseph F.. AU - Sacco, Ralph L.. AU - Singer, Daniel E.. AU - Toole, James. AU - Warach, Steven J.. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Most (∼70%) of strokes are first-ever strokes, and hence to substantially reduce the neurological burden, primary prevention is crucial. Here, highlights of the National Institute of Neurological Disorders and Stroke workshop Stroke Risk Assessment and Future Stroke Primary Prevention Trials ...
Buy Hydroxycarbamide (hydroxyurea) 500mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
The use of statins or fibrates was associated with a one third lower risk for stroke in older adults without previous vascular disease in a new observational study.
The Hugs Shirt. The Ferret prefers his hugs bear style not virtual, but the F+R Hugs Shirt is bound to enthuse legions of eager young things anxious for a textile caress. Oh yes. [via the rather delicious We Make Money….]. F+R Hugs is a wearable system that allows to feel the physical closeness of a distant loved one, bringing the pleasant sensation of a hug to body and mind. Is designed to satisfy a desire shared by many people: communicate emotions to distant people we love in a tangible way. Functionallity and use of design: The F+R Hugs system works through a mobile phone network. F+R Hugs shirts receive the input of heart beat, touch and body temperature of the remote loved one, and output it, recreating (through actuators embedded in the shirt) the pulsation, physical pressure, and warmth of a real hug. ...
Firstly, you need to make sure youre getting enough hugs. Experts range from recommending between 8 - 12 hugs daily.. Secondly, you need to make sure that your hugs count. A half-hearted attempt will not have the same results. Give into the hug, throw both arms around your hug partner and fully embrace them, the longer the physical connection the better. I like to practice 3 breath hugs, no matter how busy you are, you can stop for this time. I also prefer to count breaths as oppose to seconds as that keeps me more in tune with my own bodys rhythm.. Finally, be the hug. Dont think about what you are cooking for dinner, your to do list or a meeting at work. The best way to get the most out of your hug is to focus on how it feels. Be mindful of the weight of the other person and how their body feels as it connects with yours.. Be the hug.. The Contented Family Hugging Challenge. For one week I am going to monitor my hugs. I am interested to see if I already hug enough, I have never counted so I ...
He also loves to hug and not let go. Hes a good hugger and thats where the Teddy part comes in...like a big ol teddy bear. He is the one who taught me that there are different kinds of hugs. The side hug...for people you dont really want to hug. The back slapping hug....which mocho guys usually do. The close friend and family hug...where your right arm goes over the other persons left shoulder and left arm goes under the other persons right arm. Thats the best hug for squeezing and not letting go. And the awkward hug, unless youre married and like to hug like this...(which I do)...woman hugs mans waist and man loosely wraps his arms around woman. That too is good for squeezing and not letting go ...
Hugs are good for your heart, your blood pressure and your overall health -- just a few of the reasons to hug your loved ones today.
Download the Free Hugs soundtrack here: Sick Puppies New Album Tri-Polar Available Now! http://www.itunes.com/sickpuppies Get your Free Hugs t-shirts here: http://www.bandmerch.com/freehugscampaign...
arm hug pillow hasbeen chosen by the newly married couple to perform your house. arm hug pillow. Along with its style that is modern but nonetheless straightforward, this table been because of several advantages such as could be applied as a way of collecting together a childs learning, your family, a spot so forth and to place the kitchen equipment.
Studies show we need 4 hugs a day for survival. We need 8 hugs a day for maintenance. We need 12 hugs a day for growth. And did you know that, on average, people spend one hour a month hugging? That doesnt sound like much, but when you consider that the average hug is under 10 seconds long… thats a lot of hugs ...
My partner kept suggesting I sleep poor thing he was tired but I kept saying I couldnt...until someone else suggested it of course. My sisters put me on my side and encouraged me to try to sleep between contractions. I did and a few minutes after I felt a thump in my vagina, I got up quick and ran to the foot of the bed. I felt the contractions hug my baby hug every piece of feet , legs...everything...it was both amazing and overwhelming. I was freaking out and started to panic I had never felt this before my womb hugging my semillas body...my womb guiding me telling me where the baby was what my baby was doing....wow! I kept yelling The babys coming! The babys coming! In that moment of panic Panquetzani said Its ok your body will know what to do. I closed my eyes and I felt the baby swim down and slipped into her fathers hands...then I guess she slipped out because I heard a cry and dad was panicking that he dropped the baby....lol thats the last time I trust him to catch a ...
Research activities are an integral part of HUGs mission and is done in close collaboration with the University of Geneva Faculty of Medicine.
Sometimes all you need is a hug. Not only do they feel warm and cosy, but hugging is also good for our mentality. Research has shown how hugging releases oxytocin - the love hormone - which helps us bond with each other, and can also reduce blood pressure. The positive effects of hugging could even help you ward off a winter cold.
This brings me to the point of this post which is something I really need us to pay attention to. I think its about time we start teaching our kids about consent and setting boundaries around themselves or their bodies. When our kids meet family, friends or even strangers for the first time, we usually instruct (for lack of a better word) them to hug or kiss strangers in a bid not to make them seem rude or unfriendly. This is very common, and not unconnected to our culture. Sometimes, we go a bit far by forcing them to do so, even when they are clearly not comfortable with it. ...
Jump Clubb, an anonymous group from Beverly Hills, offer up A Frozen Hug. Their debut LP The Love Of No Dance is out October 6th.. audio ...
Hug is defined by the Oxford dictionary as to clasp tightly in the arms, especially with affection; embrace. Yet, a simple vocabulary with a simple action
Gainesville Rabbit Rescue Inc. offers the opportunity to serve your community through Want to HUG a BUNNY?!?. This is an ongoing opportunity located in Gainesville, Florida.
Free flashcards to help memorize facts about HUG Chap 2. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
This trial is investigating the efficacy and safety of peginterferon alfa-2b [AOP 2014, P 1101; AOP Orphan Pharmaceuticals AG] versus hydroxycarbamide
A good way to evaluate the scientific merit of a conclusion is to think about how you would go about researching it under ideal conditions. If we want to test the hypothesis that dogs dont like hugs, there are simple ways to get closer to an answer than by looking at random pictures online. First, you would want the dogs in an environment that doesnt stress them out, preferably at home. That would allow us to rule out the surroundings as a source of stress and focus purely on the hugs. Second, you would want to control for the person doing the hugging. In this case, the findings are seeking to scold dog owners for forcing human affection onto dogs, so the dogs should only be hugged by people they know and trust. Finally, we would control the situation. Are the hugs happening out of the blue or is the dog relaxing with its owner on the couch after a long day of hiking? These are things that matter ...
Man, the kids are amazing. I expected to have some smart-alec kids here and there booing us or whatever, but they get right into it. Now I totally understand, because I would have loved a band to come to our school, and its an excuse for them to get out of class. We also get to do a workshop with them afterwards, and they can ask us questions about the industry, and watch us set up and soundcheck, so its a real learning experience. We cant play Im Not A Whore, and we find alternatives for a couple of swear words, but for the most part its really relaxed. The obvious rules are no swearing and always being courteous, although were not allowed to hug the students front-on. We do signings after the show and a lot of the students want a hug, but were only allowed to do side hugs. We thought it was funny, but rules are rules ...
I like hugs to some extent, just so theyre not over the top. Since Mama works from home, she often hugs and kisses me during the day while Im taking my naps. In the evenings, I wait for her to come in the room to play with me. However, I dont always play. Sometimes I just watch the toy and then walk out on both her and the toy to eat some foodies in the kitchen. Other times, after playing, I climb in her lap for a few minutes while she sits on the floor with me. Whatever my mood may be, I wait every night for her to come in and give me some kind of attention. If she works really late, Ill go out to her and let her know Im waiting. Back to the original subject of hugs: do you like them or are you more reserved or do you prefer other means of affection? ...
Surprisingly, part of my discovery in examining how I feel this time around, is that I dont feel any additional pain because we had to also inform family and friends of the miscarriage. This has been my excuse for not informing others during the trial, as I assumed that family would get overly excited at an announcement, and it would only add to my pain to feel responsible for communicating the loss with others. Instead, Ive appreciated everyones texts and prayers. It certainly helped that everyone was very considerate when I said I didnt want to talk those first few days after the second ultrasound. Over all I feel like communicating during this trial may have helped me to feel closer and more grateful for those relationships ...
I was late making moms breakfast and she smarted off to me that she has never been fed this late and thought I wasnt going to feed her at all! She is totally...
Not sure where Im going with this. When I went to Pixton to try to create something to distract myself, I just kept slapping one thing after another, not sure of what Id come up with. Theres a story there, but Ill probably get back to it much later. Or never. Tuesday, June 6, 2017…
As you have probably already heard, Women Thinking, inc has spent the last couple years working on a project funded by the JREF to survey parents who are fence-sitters on the issue of vaccinating their children. The project is a kind of market survey to learn which arguments these parents find most persuasive in convincing them that vaccinating their children…. Read More » ...
Number one: Im sick thats why my voice sounds weird. Number two: I was holding my iPad with my knees so thats why the screen is shaking
Chrissy Teigen is cracking up that her daughter, Luna, refuses to hug her - but will happily hug a stranger dressed as Minnie Mouse.
Hug a GI Day is for all the men and women who proudly serve for your country. You can give a big hug to all GIs you see today to thank them. If you do not know any GIs show ...
Here is the link: http://www.dailystrength.org/c/Bipolar-Disorder/forum/Crisis-Center/8246624/lastpage Thanks bunches!! Hugs.
Mike had stayed with Isaiah overnight, so I headed down to the hospital early in the morning. When I went to his inpatient room it was empty. I hurried down to the second floor to catch up with them and luckily got there just before they entered the pre-surgical area. For whatever reason, Isaiah was being distant from me and wouldnt give me a hug. I was heartbroken. It was as if I needed him to support me, instead of me supporting him. I knew he was tired and did not grasp the seriousness of the situation, but it was still hard for me to accept that he would not provide me with the affection I so desperately needed at that moment. The anesthesiologist came to examine Isaiah and talk to us. Before I knew it, they were ready to take him away. For all of Isaiahs other procedures I had always been allowed to carry him into the procedure room and stay with him until he drifted off peacefully, like the perfect patient, under the spell of the magical bubblegum-scented anesthetic. This time was ...
Oh no….Emma, my heart goes out to you and Ruggles. Hug each other tightly and please know you did the right thing for Rotley.. ...
In keeping with CreativeWorks tradition of quality and speed when it comes to any project, CW designed and created the 3-D Pozles Universe, from scratch, in a phenomenal 4 days! In less than 100 hours from contact, or in less time than it would take to drive across the United States, CreativeWorks built an entire, imaginative 3-D Universe for Big Hug Productions ...
I am trying to get the div to hug the image, it seems that the vertical side of the DIV do, but the horizontial edges dont. I have tried different things. and I cant seem to get rid of the white space. My only other option is to use position and set everything static on the page, I really dont want to do that .. I just want the little white spaces gone. Anyone have any suggestions? Here is a link to my page cconway.com/v5 Thanx Chuck
Its The Odd Couple, but with a reanimated chunk of beef and lots of swearing. But it comes with your very own hug machine to make you feel loved ...
Thursday night I was finally able to land a date with a very attractive woman I met a few weeks before. All went well -dinner, club, dancing, light nightcaps- then came the pivotal moment of every first date. Go for the kiss or hug?
My child has fine motor issues, cannot ride a bike with training wheels at age 5, Is constantly touching things. Hugs constantly and impulsively, does
We couldnt miss a paddle on such a wacky day as this! We decided because of the fog to stay close together and hug the north shore of the bay, then turn north at the point and go towards the light house. If we went slow and kept in visual range of each other and the shore, we should be okay. Wed have to be careful -- maybe more surprises were coming ...
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 38
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 26
Sickle Cell Disease (SCD), is the most common inherited serious blood disorders. It is characterised by chronic anaemia, recurrent attacks of severe pain and complications leading to the blockage of blood flow. The mortality rate tend to be high.. Approximately, 80 per cent of babies born with the disease, globally, are in Sub-Saharan Africa. Between 80 and 90 per cent of these children die before their fifth birthday.. This group of blood disorders is reported to account for five per cent of under-five mortality in the Sub-Saharan Africa and up to 16 per cent in West Africa (WHO Report, 2006).. More than 400,000 babies are born with the sickle cell disease across the world, every year, while in Ghana, 15,000 out of 959,000 newborns, are estimated to have the disease - typically inherited from a persons parents.. The cost of treatment is high in the country and throughout the African Continent. Added to this, is the limited medical services.. A serious gap in the management of the disease in ...
Sickle cell anemia is a genetic disorder that affects blood and necessitates frequent blood transfusions in certain cases. Test your knowledge on sickle cell anemia by taking this quiz.
Background: Sickle cell anaemia induces an abnormal haemoglobin (Hb S) synthesis. Hb S undergoes polymerization and causes the red blood cell (RBC) sickling with the production of reactive oxygen species (ROS). The present work aims to determine the antioxidant and anti-sickling activities of the combination of Theobroma cacao (T. cacao) extracts from different regions in Cameroon. Methods: The extract combinations (Santchou and Obala (CSOH), Bertoua and Mbalmayo (CMBH)) was prepared using water/ethanol (30v/70v; pH=3). Ferric Reducing Antioxidant Power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH°) and 2,2-azino-bis-[3-ethylbenzo-thiazolone-6-sulfonic acid] (ABTS°) scavenging properties of extracts were determined for the antioxidant capacity. The liver homogenate protective activity of extracts was estimated by measuring Superoxide dismutase (SOD), glutathione peroxidase (GPX), Malondialdehyde (MDA) and reduced glutathione (GSH). Osmotic fragility reduction and anti-sickling properties of the
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
Got a question about sickle cell anemia? Text it to 646464 (OHOHOH). --- There is good news on the horizon in sickle cell research. Researchers at The Childrens Hospital of Philadelphia (CHOP) are exploring a number of ways to stop the disease in its tracks and develop treatment option...
Free essay examples, how to write essay on Sickle Cell Anemia 3 example essay, research paper, custom writing. Write my essay on sickle cell blood.
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TY - JOUR. T1 - Preventing ischemic stroke. T2 - Current approaches to primary and secondary prevention. AU - Ingall, Timothy J.. PY - 2000/5/15. Y1 - 2000/5/15. N2 - Preventing stroke is the most important strategy for reducing the cost of this disease. Management of modifiable risk factors, especially hypertension and cigarette smoking, has the greatest impact on prevention of first stroke. Other primary prevention strategies include: Oral anticoagulation with warfarin for selected high-risk patients with nonvalvular atrial fibrillation; Carotid endarterectomy for selected patients with carotid artery stenosis greater than 60%; Regular physical exercise; Treatment with statin medications for patients who have coronary artery disease with or without hyperlipidemia; Routine use of antiplatelet medication has no proven role in primary stroke prevention, although aspirin is often prescribed for patients with vascular risk factors who have not yet had symptoms of either stroke or ischemic heart ...
Find out more about enrolling in GlycoMimetics Phase 3 trial for rivipansel for the treatment of vaso-occlusive crisis in sickle cell disease patients.
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Cohen and his team chose to study hugging as an example of social support because hugs are typically a marker of having a more intimate and close relationship with another person.. We know that people experiencing ongoing conflicts with others are less able to fight off cold viruses. We also know that people who report having social support are partly protected from the effects of stress on psychological states, such as depression and anxiety, said Cohen. We tested whether perceptions of social support are equally effective in protecting us from stress-induced susceptibility to infection and also whether receiving hugs might partially account for those feelings of support and themselves protect a person against infection.. In 404 healthy adults, perceived support was assessed by a questionnaire, and frequencies of interpersonal conflicts and receiving hugs were derived from telephone interviews conducted on 14 consecutive evenings. Then, the participants were intentionally exposed to a ...
What are the different types of therapy hugs, long hugs, short hugs, A frame hugs, sexual hugs, bear hugs, stealth hug, epic fail hug etc.
When Daddy came home from work, He just wrapped me in His arms and told me that I needed a hug. It was a long hug. The kind where after a few minutes you get kind of squirmy and uncomfortable, especially when you arent really in the mood. When He let go, He explained that He had read a study that claimed hugging actually brings down elevated heart rates and can reduce blood pressure ...
This Hugs & Drugs Tank Top is printed on a Tank Top and designed by t-shirt. Available in many sizes and colours. Buy your own Tank Top with a Hugs & Drugs design at Spreadshirt, your custom t-shirt printing platform!
Donation Helps to Fund 25 Bottle Schools in Latin America INDIACSR News Network Plano, TX : WorldVentures Foundation™, the philanthropic arm of WorldVentures™, the leading direct seller of vacation club memberships, said that it has raised and donated over $100,000 to Hug It Forward, a grass-roots organization that facilitates education and awareness by empowering communities to build schools using eco-bricks. Because of the efforts of WorldVentures Independent Representatives, Hug It Forward is now able to develop eight new schools in Guatemala. Since October 2009, the organization has completed 25 successful bottle school projects, at an average cost of $6,500 per classroom.. We are extremely proud of our Independent Representatives donating to the WorldVentures Foundation for such a worthy cause as education, live at our biggest training event of the year, WorldVentures Co-Founder and Chief Visionary Officer Wayne Nugent said. Our Representatives and DreamTrips™ Members have ...
Start of a 2nd date, kiss on cheek, lips or just hug? At the start of a 2nd date (if you havent kissed yet) but want to show you are interested and like them what is the best thing to do? Hug them, Kiss on the...... asked under Dating
The last one is called the Super-Long-Oh-So-Passionate Hug. This is similar to the bear hug but it lasts longer and you cling to your loved one for several minutes, or even hours if you can handle it. I could just imagine myself doing this if I havent seen someone for a long long time. Sometimes when you miss the person you love, this is one way to show how much youve missed him. Do not do this with a person youre not in a relationship with or else it will really feel awkward or worse, embarrassing. ...
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Kid hug heart Vector. csp8444425 - Little kid hugging a big heart. Affordable Royalty Free Stock Photography. Downloads for just $2.50, with thousands of images added daily. Subscriptions available for just $39.00. Our stock photo image search engine contains royalty free photos, vector clip art images, clipart illustrations.
Ann shares her experience of the infamous MS Hug, a painful condition that some people living with MS have periodically around their chest and torso.
Tim Harris, owner of Tims Place, is the countrys only restaurant owner with Downs Syndrome, and the joy he gets from serving people good food carries over into his diners most famous export: hugs.
Cannabinoids all impact the receptors of the brain, in a means much like how opiates do. The receptors are located in numerous areas of the central nervous system, and when a cannabinoid interacts with them they alter how youre feeling or behave. Some affect moods, whereas others affect reminiscence or even pain notion. proprioceptive enter to the physique that can modulate the exercise of the PSNS and SNS, bringing the techniques into more of a balanced response and state of arousal. Light touch is often perceived as alerting and even agitating to some folks, whereas deep pressure contact is often calming and organizing to the sensory methods. While each child is different and has his or her own preferences, I contemplate deep pressure to be my go-to calming sensory technique at residence and at work. The ache and discomfort of an MS hug might have an effect on day-to-day actions, such as exercising or sleeping ...
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
Attorney Mike Horton was living with a potentially deadly abdominal aortic aneurysm. Lucky for him, his wife gave him a hug and found the pu
(AP) -- A 51-year-old Ohio man has embraced the Valentines Day spirit faster than anyone before, giving 7,777 hugs in 24 hours for a new world record.
So, getting back to Bessie. Bessie has now been upgraded to Bruno. Bruno also incorporates trigger points.. See the difference? This guy is oh-so-very much more…uh…specific. I could use this to my advantage.. Given how most chronic illnesses are like a box of chocolates…you neva know what youre gonna get…on any given Sunday I can now present a list.. A list of, Short Loin is out of service today. Please do not touch.. Or…Touch #2 on the Foreshank and Brisket and you die.. So, yes…it stands to reason that hugs most certainly DO hurt. Do I stop giving hugs?. NO. The physical discomfort cannot replace the emotional comfort created by getting/giving a hug.. BUT…I thought it might be beneficial to the community at large that if I were to, say…decline…a hug…that it in no way is to be considered an affront to you.. Better yet…if you are aware that the person you wish to wrap your arms around is a chronic badass…open your arms wide and wait for us to wrap around ...
Brad Stokes is sure that he can change the world with a hug.. And if it sounds like a big challenge, he is not only willing to prove it to one person, but to thousands.. Stokes - one member of the four-person Kindness Crew - demonstrated his passion for his goal to students Wednesday morning at Queneesh Elementary School as part of the Extreme Kindness Crew touring 11 Comox Valley schools this week.. Stokes is in the middle of attempting to speak to 10,000 students prior to Christmas about the value of kindness in hopes to inspire students to create their own acts of kindness towards each other and their communities.. Random acts of extreme kindness is something you like to do while making a positive impact on the community, he said.. The Kindness Crew also includes Val Litwin, Erik Hanson and Chris Bratseth; four friends who, motivated by the 9/11 attacks, travel the world promoting kindness to make the community a better place, and in turn, it makes you happier and healthier, noted ...
Download this Little Girl Hugs A Rabbit photo now. And search more of the webs best library of royalty-free stock images from iStock.
Level Halo. Hug the right wall out of the ship. Just in the entrance of the cave, to the right theres a smaller cave that holds this skull.
Usually ships in 3-5 business days. Amoeba hugs, you know, are often fatal. Show your love of amoebas and phagocytosis with this oh-so-fashionable pillow. • 18
See the ASH Agenda for Hematology Research and research recommendations on sickle cell disease, lymphoma, the Moonshot Initiative, and more.
Objective: Apoptosis plays a dominant role in both spontaneous spermatogenesis and germ cell death. This study was aimed to investigate the functions of relate...
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They tell you no, run away from you and use up all of your money. They throw a fit, leave a mess and seem to take extra long to get anything done. But, they also cuddle with you, love to play games and ask to read a book. They tell you they love you and look up to you as their hero. Theres no doubt about it: kids are a challenge. If youre a parent, you know how grueling the role of caregiver can be.. But, being a parent is also the most rewarding experience in life. Especially if you strive to live an altruistic lifestyle, theres nothing quite so altruistic as parenting. Kids rely on you for their every need, and you show them how much you care by providing, serving and giving affection. And what better way to show affection than by celebrating today-Global Hug Your Kids Day!. Global Hug Your Kids Day is a day we can all get our arms around. Celebrated on the third Monday of July, the purpose of today is simple: hug your kids. Show them how much you love, comfort and support them by giving ...
They tell you no, run away from you and use up all of your money. They throw a fit, leave a mess and seem to take extra long to get anything done. But, they also cuddle with you, love to play games and ask to read a book. They tell you they love you and look up to you as their hero. Theres no doubt about it: kids are a challenge. If youre a parent, you know how grueling the role of caregiver can be.. But, being a parent is also the most rewarding experience in life. Especially if you strive to live an altruistic lifestyle, theres nothing quite so altruistic as parenting. Kids rely on you for their every need, and you show them how much you care by providing, serving and giving affection. And what better way to show affection than by celebrating today-Global Hug Your Kids Day!. Global Hug Your Kids Day is a day we can all get our arms around. Celebrated on the third Monday of July, the purpose of today is simple: hug your kids. Show them how much you love, comfort and support them by giving ...
Yes but not all the time, you only get aroused when the hug is with someone you are very sexually attracted to or someone who rekindles some sex appeal to you. It also depends on what is in someones mind at the time of the hug. A hug that is followed by an eyes contact and smike mostly turns guys on ...
Hello, Thanks for your thanks, very kind comments, the cyber-hug and the donation to the Robert James Frascino AIDS Foundation. All are warmly appreciated. Im delighted you too have found your...
Archie is just as disappointed and confused as I am. And of course, Jack went to all these appointments with me and knew that the bloodwork today was to see if there were any babies growing in my tummy. So when we picked him up from school, and I was upset, he wanted to know why. I was on the phone with my mom and she was upset that I told him how I did, but he needs to know. He knew that we had put babies back in there, the logical question is what happened to them? So he asked and I told him that I was upset because there werent any babies in my tummy and that meant that we had more time for us to have him all to himself. He was fine with that and gave me hugs and kisses. Then a little later he asked me where the babies went. I explained that they went to heaven because God was ready for them. He asked how they got there, and I told him that it was like God gave them a big hug and just wrapped them up in His arms. He asked me if it was like a sliding star that slid up to heaven from earth, ...
Hours after Leah was born, we learned that Leahs heart rate dropped below the desirable level and her cord blood was a bit acidic, indicating low levels of oxygen were circulating in her body. Low oxygen levels greatly increase the risk and extent of brain damage in a newborn. In order to counteract any further brain damage due to lack of oxygen, Leah was placed on a cooling cap apparatus, reducing her brain and body temperature to a semi-hypothermic level of 33-35 degrees Celsius for 72 hours. This process reduces brain activity and allows the brain to halt the degenerative process and begin healing. Along with the cooling cap or cooling blanket, newborns must also be hooked up to both a CFM and aEEG monitor. ...
Now, for most people, pain killers are a non-issue, but somebody who has a history of substance abuse needs to be careful. I used to smoke so much pot that I couldnt even get high anymore. I was doing about an ounce a week of the strong stuff. I ate carbs til I passed out, sick, eating myself to a morbidly obese 306 lbs. Alcohol was never really a problem for me, but I could see how it could quickly become one, based on my history ...
To my friend Amber who was with me yesterday, I know how much your husband loves you. I have to say, I love you too. You were amazing and supportive and kept me sane during a traumatic day. I will never ever forget what you did for me yesterday and if I can do anything for you (after of course, kicking cancer to the curb), I am there. You transcended to not just a close friend but truly a sister to me yesterday. *Interwebs high five* You even got a hug from my sweetie yesterday. Ive never seen him hug anybody else. Count him as a fan of yours, as well ...
BETHEL - The third annual Team Hailey Hugs walk-a-thon took place on Saturday at Crescent Park elementary school in Bethel, with the turnout this year better than ever, and so were the donations. Team Hailey Hugs was created by the Steward family of Bethel, and some of their friends, in honor of their daughter, Hailey…
I am very thankful for my big girl Makenna. She is a handful also. She is hitting the threes early I think. She causes me the most trouble. She can be the sweetest, most lovable girl and then a second later, she is a hellion! I just dont know what to do with her sometimes. I have tried so many different ways of punishing her and nothing seems to work. I guess I just have to stick to one and go with it. She gave us our biggest scare yet a couple months ago. I am sure I will have many more scares like that in the future with any of them, but I pray it is not any time soon and it turns out better than worse. The worst feeling in the world is to know your child is hurting, or very sick and there is nothing you can do about it. I love her hugs, they are the best hugs in the world! She is definitely a mommas girl...most of the time. She is still very very shy, but once she warms up to you, she is so much fun ...
... hematologic agents MeSH D27.505.954.502.119 - anticoagulants MeSH D27.505.954.502.135 - antisickling agents MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects T. Kassa, M. ... Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects ...
"Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these ... "Antisickling Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Antisickling Agents" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Antisickling Agents". ...
Hemoglobin modification and antisickling agents. Carbon monoxide (CO) is a potent antisickling agent, because it attaches to Hb ... Induction of HbF and antisickling agents. Irreversible sickling does not appear to be the driving factor for red cell adhesion ... Drugs that increase HbF levels are the archetypal antisickling agents, because HbF interferes with polymerization of HbS, ... Anticoagulants and antiplatelet agents. Although coagulation is chronically activated in SCD,79⇓⇓⇓-83 no specific clinical ...
Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. Pharmacogn Rev 7(13):53-60PubMed ... Soforowa EA (1975) Isolation and characterization of an anti-sickling agent from Fagara zanthoxyloides. Lloydia 38:169-171 ... Adesanya SA, Idowu TB, Elujoba AA (1988) Anti-sickling activity of Adansonia digitata. Planta Med 54(4):374PubMedGoogle Scholar ... Mojisola OC, Adebolu EA, Alani DM (2008) Anti-sickling properties of Carica papaya Linn. J Nat Prod 1:56-66Google Scholar ...
Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
Antisickling Agents. Additional relevant MeSH terms: Anemia, Sickle Cell. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. ... ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. ...
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ... Anti-HIV Agents. Anti-Retroviral Agents. Antiviral Agents. Anti-Infective Agents. Antimetabolites. Reverse Transcriptase ... Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic ...
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ...
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ...
Antisickling Agents * Biomarkers * Hemoglobins * Thrombospondin 1 * L-Lactate Dehydrogenase * Hydroxyurea Grant support * UL1 ...
Dichloromethane as an Antisickling Agent in Sickle Cell Hemoglobin. Fourier Transform Infrared Spectroscopy of Hemoglobin. A ...
Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 ... Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312. Coordinates. PDB Format Method. X ... Highly Potent Antisickling Agents. To be Published Release Date. 2011-04-06. Peptides. Hemoglobin subunit alpha: AC. Hemoglobin ...
Desickling Agents (0) see Antisickling Agents. Designer Drug (1). Detergents (31) • Purifying or cleansing agents, usually ... Defoaming Agents (0) see Antifoaming Agents. Defoliants, Chemical (3) • Herbicides that remove leaves from trees and growing ... Dopamine Agents (151) • Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on ... Dermatologic Agents (125) • Drugs used to treat or prevent skin disorders or for the routine care of skin. MeSH ...
A Single Dose Pharmacokinetic Study of the Antisickling Agent Cetiedil, 1983. *Nutrition and Sickle Cell Disease, 1986 ...
Vasodilators and anti-sickling agents. Indications and usages, anatomical therapeutic chemical and diseases classification ...
Targeting betaCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.. Kassa T, ... Interactions of an anti-sickling drug with hemoglobin in red blood cells from a patient with sickle cell anemia.. Strader MB, ... Antisickling drugs targeting betaCys93 reduce iron oxidation and oxidative changes in sickle cell hemoglobin.. Kassa T, Wood F ...
... presently receives salary support for providing consultative advice to Mast Pharmaceuticals regarding an antisickling agent), ... POTENTIAL CONFLICT OF INTEREST: Dr Wang: consultancy, Pfizer, participated in a meeting to discuss an antisickling drug; Dr ... and patents: provisional patent for agent to treat sickle cell disease; the other authors have indicated they have no potential ...
Patient 1 exhibits 31.5% of total Hb as anti-sickling hemoglobins (HbFG16D + HbF + HbA2) with 20.2% of total Hb from HbFG16D at ... regimen involving melphalan and other agents. This conditioning regimen, which is investigational and subject to further study ... Patient 2 exhibits 22.2% of total Hb as anti-sickling hemoglobins with 8.6% of total Hb from HbFG16D at 12 months after ... Fetal hemoglobin has very potent anti-sickling properties relative to adult hemoglobin (HbA). RVT-1801 uses a patented, ...
This second moiety is, for example, a drug carrier and/or a therapeutic agent such as, for instance, an anti-inflammatory agent ... In both patients, significant anti-sickling effects and prolongation of red cell survival was observed. Beutler did not ... Besides such inert diluents, compositions can also include adjuvants, such as wetting agents, emulsifying and suspending agents ... Other auxiliary, non-toxic agents may be included, for example, polyethylene glycols or wetting agents. ...
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin ... Antimicrob Agents Chemother 48 : 4097-4102.. * Berenbaum MC, 1978. A method for testing synergy with any number of agents. J ... Antimicrob Agents Chemother 41 : 2345-2351.. * Hatabu T, Takada T, Taguchi N, Suzuki M, Sato K, Kano S, 2005. Potent ... Antimicrob Agents Chemother 46 : 1510-1515.. * Sannella R, Messori L, Casini A, Vincieri FF, Bilia AR, Majori G, Severini C, ...
Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues. Abraham, D.J., Mehanna, A.S., ... Agents Chemother. (1998) [Pubmed]. *Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic ... Modification by pharmacologic agents. Castor, C.W. Arthritis Rheum. (1975) [Pubmed]. *Oxidative stress and Mrp2 internalization ... inhibitory concentration values ranging from 0.3 to 6.0 microM and has been shown to restore sensitivity to alkylating agents ...
Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
Physiological and X-ray studies of potential antisickling agents. Abraham, DJ; Perutz, MF; Phillips, SE ...
Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit (Carica papaya)," Transactions of the Royal ... G. I. Ekeke and F. O. Shode, "Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract," Planta Medica ... J. A. Walder, R. H. Zaugg, R. S. Iwaoka, W. G. Watkin, and I. M. Klotz, "Alternative aspirins as antisickling agents: acetyl-3, ... K. Gamaniel, S. Amos, P. Akah et al., "Pharmacological profile of NIPRD 94/002/1-0: a novel herbal antisickling agent," Journal ...
New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo? Br J ...
Abraham, D.J., Gazze, D.M., Kennedy, P.E. and Makotoff, M.,Design, synthesis, and testing of potential antisickling agents. 5. ... Howe, R. and Smith, L.H.,Alkanolamine derivatives - beta-adrenergic blocking agents, U.S. Patent 3,712,927, 1973. ...
  • DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. (sbir.gov)
  • And Xickle® RBC-Plus™ is a more potent anti-sickling agent than Niprisan, a drug approved to treat sickle cell disease in Nigeria. (xickle.com)
  • This issue features highlights from the 2017 ASH Annual Meeting, including a look at the first anti-sickling agent for sickle cell disease, and more. (ashclinicalnews.org)
  • The exclusion criteria were any significant medical conditions other than sickle cell disease, including diabetes mellitus, renal failure or heart failure, pregnancy, and history of treatment with any antisickling agents within 12 months of initiation of this study. (biomedcentral.com)
  • Pharmacodynamic effects will be assessed by measuring partial pressure of oxygen at which 50% of hemoglobin is saturated with oxygen (p50) while breathing normal air, blood oxygen levels (SpO2), ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. (clinicaltrials.gov)
  • We demonstrate that polymerization of sickle hemoglobin (HbS) is responsible for this growth arrest of intraerythrocytic P. falciparum parasites, with normal hemoglobin digestion and growth restored in the presence of carbon monoxide, a gaseous antisickling agent. (pnas.org)
  • HbS Aggregation Is An Inefficient Process Attempts to rationally design antisickling agents possess often viewed the sickle hemoglobin both as the drug target as well as the starting point for lead finding. (cancerresources.com)
  • Using structure-based drug design, several hemoglobin allosteric effectors with ideal oxygen modulating properties potentially useful for the treatment of hypoxic diseases and sickle cell anemia have been discovered including 5-hydroxymethylfurfural (5-HMF), a safe, potent, and highly effective anti-sickling agent. (vcu.edu)
  • Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes : Highly Potent Antisickling Agents. (expasy.org)
  • AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. (biomedcentral.com)
  • Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F. Traditional medicine as a source of new therapeutic agents against psoriasis. (koreascience.or.kr)
  • Identification of allosteric binding site modulators have gained increased attention for their potential to be developed as selective therapeutic agents with fewer side effects. (vcu.edu)
  • 3. More than two hospital admissions for painful VOC in the prior 12 months, whether on any anti-sickling agents (e.g. hydroxyurea, L-glutamine, or transfusion therapy) or not. (ichgcp.net)
  • The only existing therapy approved for SCD is the anti-cancer agent hydroxyurea (HU). (grantome.com)
  • A prevailing question about the suitability from the HbS molecule as focus on for drug advancement is due to the perceived restriction enforced by its high articles level in guy (about 450g) [61], recommending an intolerably high dosage of antisickling substance would Ivabradine HCl (Procoralan) be necessary to obtain clinically useful levels of inhibition [85]. (cancerresources.com)
  • hexane, dichloromethane and ethyl acetate crude extracts of Syzygium guineense of DRC, betulinic acid, betulinic acid acetate and maslinic acid showed a high antisickling activity, more than 70% of normalization. (ukzn.ac.za)
  • Others crude extracts and pure isolated compounds were found to be non-active antisickling agents. (ukzn.ac.za)
  • Antisickling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
  • The unripe fruit contains glycine, phenylalanine and try- ptophan with reported antisickling properties (Pizzorno solution (0.6 ml) was introduced gently under the liquid paraffin. (who.int)
  • K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit ( Carica papaya )," Transactions of the Royal Society of Tropical Medicine and Hygiene , vol. 81, no. 3, pp. 510-511, 1987. (hindawi.com)
  • Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)
  • Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. (nih.gov)
  • The FDA granted priority review to a supplemental biologics license application for the anti-PD-1 agent pembrolizumab for adult and pediatric patients with relapsed/refractory primary. (ashclinicalnews.org)
  • Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic potential within 3 months of study start or the expected need for such therapy at the time of enrollment. (clinicaltrials.gov)
  • The principal use of HU has been as a myelosuppressive agent in the myeloproliferative syndromes. (mjhid.org)
  • Design, synthesis, and testing of potential antisickling agents. (springer.com)
  • Antileishmanial activity of amphotericin and other antifungal agents entrapped in liposomes. (ajtmh.org)
  • To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. (pianolarge.tk)
  • To AesRx's knowledge, Aes-103 is the only direct anti-sickling agent in or near clinical trials. (grantome.com)
  • GBT440 (generic name voxelotor) is a novel anti-polymerization and anti-sickling agent currently undergoing clinical evaluation for the treatment of SCD. (readbyqxmd.com)
  • Inherited genetic modifiers and pharmacological agents that enhance vertebrate hemoprotein (HbF) expression reverse the clinical severity of erythrocyte sickness (SCD). (journalgazett.com)
  • Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. (springer.com)
  • E. A. Sofowora, "Isolation and characterization of an antisickling agent from the root of Fagara zanthoxyloides," in Proceedings of a Symposium Fagara and the Red Blood Cell , A. Sofowora and A. I. Sodeye, Eds. (hindawi.com)
  • Xickle ® RBC-Plus™ guards against those agents that can distort red blood cells and cause them to clog blood vesicles and cause pain and organ degeneration and possible organ failure. (xickle.com)
  • Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (nih.gov)
  • Our studies of the effect of the medium on the behaviour of the di-anion (4) towards electrophilic attack by the bromo-alkene (5) resulted in the synthesis of analogues (2) and (6d) of a known anti-sickling agent (3) in high yield. (elsevier.com)
  • Whilst the treatment paradigms fundamentally vary between different aetiologies, there are overlaps with pharmacological regimes in immunosuppressive agents and anti-platelet therapies. (bvsalud.org)
  • Both patients received a patient-specific AruLite™ reduced intensity conditioning (RIC) regimen involving melphalan and other agents. (prnewswire.com)
  • Due to its once-daily dosing regimen, clopidogrel is the predominantly prescribed therapeutic agent to treat subjects suffering from ACS. (patentsencyclopedia.com)
  • These agents may be continued during the study period. (ichgcp.net)
  • However, subjects are not allowed to be started on any of these agents during the study period. (ichgcp.net)
  • 10 ] In addition to its use as an anti-cancer agent, HU has found some marginal applications in dermatology. (mjhid.org)
  • This graph shows the total number of publications written about "Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these publications. (sickkids.ca)
  • Areas covered: We review recent advances in pharmacotherapy for SCD and summarize promising synthetic agents that are in late-stage development (phase 3) for SCD. (readbyqxmd.com)
  • A pesticide or chemical agent that kills mites and ticks. (nih.gov)
  • Other areas of investigation included butanol vapor therapy in pulmonary edema and non-covalent antisickling agents for sickle cell hemoglobinopathy. (ecu.edu)
  • Agents that promote the excretion of urine through their effects on kidney function. (nih.gov)
  • A method for testing synergy with any number of agents. (ajtmh.org)
  • Below are the most recent publications written about "Antisickling Agents" by people in Profiles. (sickkids.ca)
  • Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions. (sickkids.ca)
  • In a phase I trial of patients with relapsed/refractory peripheral T-cell lymphoma (PTCL), combining romidepsin and pralatrexate - two agents approved by the U.S. (ashclinicalnews.org)