Antisickling Agents
Hemoglobin, Sickle
Erythrocytes, Abnormal
Anemia, Sickle Cell
Oxyhemoglobins
Erythrocyte Membrane
Oxygen
Erythrocytes
Solubility
Drug Repositioning
Hydroxyurea
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Double-Blind Method
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Pseudomonas aeruginosa
Dietary Proteins
Stavudine
Nelfinavir
Didanosine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Treatment Outcome
HIV Infections
Anti-HIV Agents
Nasal Decongestants
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Names
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
Dentifrices
National Library of Medicine (U.S.)
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Nephrology
Hypericum
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Poaceae
Songbirds
Phloroglucinol
Fetal Hemoglobin
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Gemfibrozil
beta-Thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Hypolipidemic Agents
Anions
Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. (1/147)
1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore A23187 (2 microM) to rabbit red cells suspended at a haematocrit of 1% in a low potassium solution ([K]0 0.12-0.17 mM) at 37 degrees C. Net movement of K+ was measured using a K+-sensitive electrode placed in the suspension. 3. The concentrations (microM +/- s.d.) of the compounds tested causing 50% inhibition of K+ loss were: quinine, 37 +/- 3; cetiedil, 26 +/- 1; the cetiedil congeners UCL 1269, UCL 1274 and UCL 1495, approximately 150, 8.2 +/- 0.1, 0.92 +/- 0.03 respectively; clotrimazole, 1.2 +/- 0.1; nitrendipine, 3.6 +/- 0.5 and charybdotoxin, 0.015 +/- 0.002. 4. The characteristics of the block suggested that compounds could be placed in two groups. For one set (quinine, cetiedil, and the UCL congeners), the concentration-inhibition curves were steeper (Hill coefficient, nH, > or = 2.7) than for the other (clotrimazole, nitrendipine, charybdotoxin) for which nH approximately 1. 5. Compounds in the first set alone became less active on raising the concentration of K+ in the external solution to 5.4 mM. 6. The rate of K+ loss induced by A23187 slowed in the presence of high concentrations of cetiedil and its analogues, suggesting a use-dependent component to the inhibitory action. This was not seen with clotrimazole. 7. The blocking action of the cetiedil analogue UCL 1274 could not be overcome by an increase in external Ca2+ and its potency was unaltered when K+ loss was induced by the application of Pb2+ (10 microM) rather than by A23187. 8. These results, taken with the findings of others, suggest that agents that block the red cell Ca2+-activated K+ permeability can be placed in two groups with different mechanisms of action. The differences can be explained by supposing that clotrimazole and charybdotoxin act at the outer face of the channel whereas cetiedil and its congeners may block within it, either at or near the K+ binding site that determines the flow of K+. (+info)RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/147)
Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications. (+info)Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/147)
Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia. (+info)Persistent respiratory effects in survivors of the Bhopal disaster. (4/147)
OBJECTIVE: To examine the role of exposure to the 1984 Bhopal gas leak in the development of persistent obstructive airways disease. DESIGN: Cross sectional survey. SETTING: Bhopal, India. SUBJECTS: Random sample of 454 adults stratified by distance of residence from the Union Carbide plant. MAIN OUTCOME MEASURES: Self reported respiratory symptoms; indices of lung function measured by simple spirometry and adjusted for age, sex, and height according to Indian derived regression equations. RESULTS: Respiratory symptoms were significantly more common and lung function (percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), and FEV1/FEV ratio) was reduced among those reporting exposure to the gas leak. The frequency of symptoms fell as exposure decreased (as estimated by distance lived from the plant), and lung function measurements displayed similar trends. These findings were not wholly accounted for by confounding by smoking or literacy, a measure of socioeconomic status. Lung function measurements were consistently lower in those reporting symptoms. CONCLUSION: Our results suggest that persistent small airways obstruction among survivors of the 1984 disaster may be attributed to gas exposure. (+info)The reaction of deoxy-sickle cell hemoglobin with hydroxyurea. (5/147)
In addition to its capacity to increase fetal hemoglobin levels, other mechanisms are implicated in hydroxyurea's ability to provide beneficial effects to patients with sickle cell disease. We hypothesize that the reaction of hemoglobin with hydroxyurea may play a role. It is shown that hydroxyurea reacts with deoxy-sickle cell hemoglobin (Hb) to form methemoglobin (metHb) and nitrosyl hemoglobin (HbNO). The products of the reaction as well as the kinetics are followed by absorption spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. Analysis of the kinetics shows that the reaction can be approximated by a pseudo-first order rate constant of 3.7x10(-4) (1/(s.M)) for the disappearance of deoxy-sickle cell hemoglobin. Further analysis shows that HbNO is formed at an observed average rate of 5.25x10(-5) (1/s), three to four times slower than the rate of formation of metHb. EPR spectroscopy is used to show that the formation of HbNO involves the specific transfer of NO from the NHOH group of hydroxyurea. The potential importance of this reaction is discussed in the context of metHb and HbNO being able to increase the delay time for sickle cell hemoglobin polymerization and HbNO's vasodilating capabilities through conversion to S-nitrosohemoglobin. (+info)Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. (6/147)
Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this agent in pediatric patients with sickle cell anemia has not been determined. Children with sickle cell anemia, age 5 to 15 years, were eligible for this multicenter Phase I/II trial. HU was started at 15 mg/kg/d and escalated to 30 mg/kg/d unless the patient experienced laboratory toxicity. Patients were monitored by 2-week visits to assess compliance, toxicity, clinical adverse events, growth parameters, and laboratory efficacy associated with HU treatment. Eighty-four children were enrolled between December 1994 and March 1996. Sixty-eight children reached maximum tolerated dose (MTD) and 52 were treated at MTD for 1 year. Significant hematologic changes included increases in hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, and fetal hemoglobin parameters, and decreases in white blood cell, neutrophil, platelet, and reticulocyte counts. Laboratory toxicities typically were mild, transient, and were reversible upon temporary discontinuation of HU. No life-threatening clinical adverse events occurred and no child experienced growth failure. This Phase I/II trial shows that HU therapy is safe for children with sickle cell anemia when treatment was directed by a pediatric hematologist. HU in children induces similar laboratory changes as in adults. Phase III trials to determine if HU can prevent chronic organ damage in children with sickle cell anemia are warranted. (+info)Acetylation of human hemoglobin by methyl acetylphosphate. Evidence of broad regio-selectivity revealed by NMR studies. (7/147)
The development of chemical modification agents that reduce the tendency of sickle hemoglobin (HbS) to aggregate represents an important chemotherapeutic goal. Methyl acetylphosphate (MAP) has been reported to bind to the 2,3-diphosphoglycerate (2,3-DPG) binding site of hemoglobin, where it selectively acetylates residues, resulting in increased solubility of HbS. We have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC and HSQC NMR studies. These spectra of the acetylated hemoglobin adducts showed 10-11 well resolved adduct peaks, indicating that the acetylation was not highly residue specific. The chemical shift pattern observed is in general similar to that obtained recently using [1'-(13)C]aspirin as the acetylating agent (Xu, A. S. L., Macdonald, J. M., Labotka, R. J., and London, R. E. (1999) Biochim. Biophys. Acta 1432, 333-349). Blocking the 2, 3-DPG binding site with inositol hexaphosphate (IHP) resulted in a selective reduction in intensity of adduct resonances, presumably corresponding to residues located in the 2,3-DPG binding cleft. The pattern of residue protection appeared to be identical to that observed in our previous study using IHP and labeled aspirin. Pre-acetylation of hemoglobin using unlabeled MAP, followed by acetylation with [1'-(13)C]aspirin indicated a general protective effect, with the greatest reduction of intensity for resonances corresponding to acetylated residues in the 2,3-DPG binding site. These studies indicated that both MAP and aspirin exhibit similar, although not identical, acetylation profiles and target primarily the betaLys-82 residue in the 2,3-DPG binding site, as well as sites such as betaLys-59 and alphaLys-90, which are not located in the beta-cleft of hemoglobin. (+info)Preliminary report of a toxicity study of hydroxyurea in sickle cell disease. French Study Group on Sickle Cell Disease. (8/147)
AIM: To evaluate the tolerance of hydroxyurea in children affected with sickle cell disease. DESIGN: Questionnaire study of French physicians likely to treat patients with sickle cell disease. Data were collected on 101 children with sickle cell disease, treated for a median of 22 months, 36 of whom were treated for more than three years. 13 children were younger than 5 years of age at inclusion. RESULTS: Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus. Acute lymphoblastic leukaemia occurred in a girl treated for 1.5 months with hydroxyurea, this short interval arguing against a causative association. One 17 year old boy had paraparesis after 8 years of treatment. CONCLUSIONS: No major short or medium term toxicity was related to hydroxyurea in this cohort of 101 children. However, the number of children treated for more than 3 years is too few to make firm conclusions on the long term tolerance of this drug. (+info)
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Paul Rolan
... an antisickling agent, using a novel surrogate marker". In 1994 he moved into the role of Medical Director at the contract ...
List of MeSH codes (D27)
... hematologic agents MeSH D27.505.954.502.119 - anticoagulants MeSH D27.505.954.502.135 - antisickling agents MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Obafemi Awolowo University
An underlying purpose of these expansion was the view that education was an important agent of transformation and development. ... the potential anti-sickling properties of fagara zanthoxylloides, mechanisms of chloroquine -induced pruritus, a ...
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...
PRIME PubMed | Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG...
... site-specific acetylating agent toward the 2,3-DPG binding site in hemoglobin S. Download Prime PubMed App to iPhone, iPad, or ... Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in ... "Methyl Acetyl Phosphate, a New Type of Antisickling Agent: Site-specific Acetylating Agent Toward the 2,3-DPG Binding Site in ... Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in ...
Antisickling Agents | REACH
"Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these ... "Antisickling Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Antisickling Agents" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Antisickling Agents". ...
Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood Journal
Hemoglobin modification and antisickling agents. Carbon monoxide (CO) is a potent antisickling agent, because it attaches to Hb ... Induction of HbF and antisickling agents. Irreversible sickling does not appear to be the driving factor for red cell adhesion ... Drugs that increase HbF levels are the archetypal antisickling agents, because HbF interferes with polymerization of HbS, ... Anticoagulants and antiplatelet agents. Although coagulation is chronically activated in SCD,79⇓⇓⇓-83 no specific clinical ...
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A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With...
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ... Anti-HIV Agents. Anti-Retroviral Agents. Antiviral Agents. Anti-Infective Agents. Antimetabolites. Reverse Transcriptase ... Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic ...
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The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde<...
Manning, J. M., & Acharya, A. S. (1984). The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde ... Manning, JM & Acharya, AS 1984, The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde, ... Fingerprint Dive into the research topics of The mechanism of action of two anti-sickling agents: Sodium cyanate and ... The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde. American Journal of Pediatric ...
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Anti-sickling Herbs | SpringerLink
Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. Pharmacogn Rev 7(13):53-60PubMed ... Soforowa EA (1975) Isolation and characterization of an anti-sickling agent from Fagara zanthoxyloides. Lloydia 38:169-171 ... Adesanya SA, Idowu TB, Elujoba AA (1988) Anti-sickling activity of Adansonia digitata. Planta Med 54(4):374PubMedGoogle Scholar ... Mojisola OC, Adebolu EA, Alani DM (2008) Anti-sickling properties of Carica papaya Linn. J Nat Prod 1:56-66Google Scholar ...
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SWISS-MODEL Template Library | 3r5i.1
Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 ... Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312. Coordinates. PDB Format Method. X ... Highly Potent Antisickling Agents. To be Published Release Date. 2011-04-06. Peptides. Hemoglobin subunit alpha: AC. Hemoglobin ...
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Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
Trees for Life Journal - Proximate Composition and In-vitro Anti-sickling Property of Nigerian Cyperus esculentus (Tiger Nut...
Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
D Category Names List - Drug Information Portal - U.S. National Library of Medicine
Desickling Agents (0) see Antisickling Agents. Designer Drug (1). Detergents (31) • Purifying or cleansing agents, usually ... Defoaming Agents (0) see Antifoaming Agents. Defoliants, Chemical (3) • Herbicides that remove leaves from trees and growing ... Dopamine Agents (151) • Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on ... Dermatologic Agents (125) • Drugs used to treat or prevent skin disorders or for the routine care of skin. MeSH ...
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Targeting betaCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.. Kassa T, ... Interactions of an anti-sickling drug with hemoglobin in red blood cells from a patient with sickle cell anemia.. Strader MB, ... Antisickling drugs targeting betaCys93 reduce iron oxidation and oxidative changes in sickle cell hemoglobin.. Kassa T, Wood F ...
Award Data | SBIR.gov
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Patient 1 exhibits 31.5% of total Hb as anti-sickling hemoglobins (HbFG16D + HbF + HbA2) with 20.2% of total Hb from HbFG16D at ... regimen involving melphalan and other agents. This conditioning regimen, which is investigational and subject to further study ... Patient 2 exhibits 22.2% of total Hb as anti-sickling hemoglobins with 8.6% of total Hb from HbFG16D at 12 months after ... Fetal hemoglobin has very potent anti-sickling properties relative to adult hemoglobin (HbA). RVT-1801 uses a patented, ...
Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to...
This second moiety is, for example, a drug carrier and/or a therapeutic agent such as, for instance, an anti-inflammatory agent ... In both patients, significant anti-sickling effects and prolongation of red cell survival was observed. Beutler did not ... Besides such inert diluents, compositions can also include adjuvants, such as wetting agents, emulsifying and suspending agents ... Other auxiliary, non-toxic agents may be included, for example, polyethylene glycols or wetting agents. ...
The American Journal of Tropical Medicine and Hygiene | In Vitro Activity of Artemisinin in Combination with Clotrimazole or...
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin ... Antimicrob Agents Chemother 48 : 4097-4102.. * Berenbaum MC, 1978. A method for testing synergy with any number of agents. J ... Antimicrob Agents Chemother 41 : 2345-2351.. * Hatabu T, Takada T, Taguchi N, Suzuki M, Sato K, Kano S, 2005. Potent ... Antimicrob Agents Chemother 46 : 1510-1515.. * Sannella R, Messori L, Casini A, Vincieri FF, Bilia AR, Majori G, Severini C, ...
WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...
Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues. Abraham, D.J., Mehanna, A.S., ... Agents Chemother. (1998) [Pubmed]. *Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic ... Modification by pharmacologic agents. Castor, C.W. Arthritis Rheum. (1975) [Pubmed]. *Oxidative stress and Mrp2 internalization ... inhibitory concentration values ranging from 0.3 to 6.0 microM and has been shown to restore sensitivity to alkylating agents ...
Sickle Cell Anemia | Grand Strand Health
Oxidative Effects of Gemfibrozil on Anion Influx and Metabolism in Normal and Beta-Thalassemic Erythrocytes: Physiological...
Sickle Cell Anemia | Doctors Hospital
Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria
K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit (Carica papaya)," Transactions of the Royal ... G. I. Ekeke and F. O. Shode, "Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract," Planta Medica ... J. A. Walder, R. H. Zaugg, R. S. Iwaoka, W. G. Watkin, and I. M. Klotz, "Alternative aspirins as antisickling agents: acetyl-3, ... K. Gamaniel, S. Amos, P. Akah et al., "Pharmacological profile of NIPRD 94/002/1-0: a novel herbal antisickling agent," Journal ...
HydroxyureaVitroAssaysHemoglobinExtractsMeSHCompoundsExtractAnemiaTherapeutic agentsIsolationUnripeDosagePotent anti-sicklSpecificityClinical trialsDrugsTherapyAdultActivityMyelosuppressiveSearchPotentialUrineCyanatePropertiesTherapiesStudyFoundBloodTopicReviewDevelopmentActivitiesMechanismPatientsMethodPublicationsPrevent
Hydroxyurea3
- But findings from a new study, presented here at the plenary session of the American Society Hematology (ASH) 57th Annual Meeting, showed that oral agent hydroxyurea was noninferior and possibly superior to long-term transfusions. (scinfo.org)
- 3. More than two hospital admissions for painful VOC in the prior 12 months, whether on any anti-sickling agents (e.g. hydroxyurea, L-glutamine, or transfusion therapy) or not. (ichgcp.net)
- The only existing therapy approved for SCD is the anti-cancer agent hydroxyurea (HU). (grantome.com)
Vitro2
- Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes : Highly Potent Antisickling Agents. (expasy.org)
- This study validates for the first time the in vitro antisickling activity of U. molundense. (scirp.org)
Assays2
- ous extract obtained and used for antisickling assays. (who.int)
- The crude CA extract and fractions were subjected to inhibitory and reversal antisickling assays at 0.25-4.00 mg/mL concentration range. (jppres.com)
Hemoglobin6
- Methyl Acetyl Phosphate, a New Type of Antisickling Agent: Site-specific Acetylating Agent Toward the 2,3-DPG Binding Site in Hemoglobin S." The American Journal of Pediatric Hematology/oncology, vol. 10, no. 4, 1988, pp. 348-50. (unboundmedicine.com)
- Pharmacodynamic effects will be assessed by measuring partial pressure of oxygen at which 50% of hemoglobin is saturated with oxygen (p50) while breathing normal air, blood oxygen levels (SpO2), ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. (clinicaltrials.gov)
- Preclinical data indicated that the therapy is a potent anti-sickling agent with a high specificity for hemoglobin. (scinfo.org)
- We demonstrate that polymerization of sickle hemoglobin (HbS) is responsible for this growth arrest of intraerythrocytic P. falciparum parasites, with normal hemoglobin digestion and growth restored in the presence of carbon monoxide, a gaseous antisickling agent. (pnas.org)
- Solubility determination (Csat) of deoxy hemoglobin S gels demonstrated that HN2 markedly inhibited the polymerization of HbS, was significantly more effective than potassium cyanate, and is among the most potent anti-sickling agents thus far reported. (unboundmedicine.com)
- HbS Aggregation Is An Inefficient Process Attempts to rationally design antisickling agents possess often viewed the sickle hemoglobin both as the drug target as well as the starting point for lead finding. (cancerresources.com)
Extracts3
- All tested extracts displayed antisickling activity. (scirp.org)
- hexane, dichloromethane and ethyl acetate crude extracts of Syzygium guineense of DRC, betulinic acid, betulinic acid acetate and maslinic acid showed a high antisickling activity, more than 70% of normalization. (ukzn.ac.za)
- Others crude extracts and pure isolated compounds were found to be non-active antisickling agents. (ukzn.ac.za)
MeSH1
- Antisickling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
Compounds2
- Bioactivity-directed isolation of antisickling compounds from Cnidoscolus acontifolius (Mill. (jppres.com)
- To evaluate the antisickling potential of Cnidoscolus aconitifolius leaf extract, determine the most active fraction, and isolate the putative compounds. (jppres.com)
Extract2
- K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit ( Carica papaya )," Transactions of the Royal Society of Tropical Medicine and Hygiene , vol. 81, no. 3, pp. 510-511, 1987. (hindawi.com)
- The study concluded that the ethyl acetate fraction of the ethanol extract of C. aconitifolius has the highest antisickling property and identified tetramethylbicosahydropicen-3-ol as a potential antisickling agent. (jppres.com)
Anemia2
- There is continuous search for therapeutic agents from indigenous plants that can be employed in the treatment of sickle cell anemia. (jppres.com)
- Existe una búsqueda continua de agentes terapéuticos a partir de plantas autóctonas que puedan emplearse en el tratamiento de la anemia de células falciformes. (jppres.com)
Therapeutic agents2
- DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. (sbir.gov)
- Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F. Traditional medicine as a source of new therapeutic agents against psoriasis. (koreascience.or.kr)
Isolation1
- E. A. Sofowora, "Isolation and characterization of an antisickling agent from the root of Fagara zanthoxyloides," in Proceedings of a Symposium Fagara and the Red Blood Cell , A. Sofowora and A. I. Sodeye, Eds. (hindawi.com)
Unripe1
- The unripe fruit contains glycine, phenylalanine and try- ptophan with reported antisickling properties (Pizzorno solution (0.6 ml) was introduced gently under the liquid paraffin. (who.int)
Dosage1
- A prevailing question about the suitability from the HbS molecule as focus on for drug advancement is due to the perceived restriction enforced by its high articles level in guy (about 450g) [61], recommending an intolerably high dosage of antisickling substance would Ivabradine HCl (Procoralan) be necessary to obtain clinically useful levels of inhibition [85]. (cancerresources.com)
Potent anti-sickl1
- And Xickle® RBC-Plus™ is a more potent anti-sickling agent than Niprisan, a drug approved to treat sickle cell disease in Nigeria. (xickle.com)
Specificity1
- New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors. (umassmed.edu)
Clinical trials1
- To AesRx's knowledge, Aes-103 is the only direct anti-sickling agent in or near clinical trials. (grantome.com)
Drugs2
- Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. (nih.gov)
- Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (umassmed.edu)
Therapy2
- Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic potential within 3 months of study start or the expected need for such therapy at the time of enrollment. (clinicaltrials.gov)
- Other areas of investigation included butanol vapor therapy in pulmonary edema and non-covalent antisickling agents for sickle cell hemoglobinopathy. (ecu.edu)
Adult1
- The FDA granted priority review to a supplemental biologics license application for the anti-PD-1 agent pembrolizumab for adult and pediatric patients with relapsed/refractory primary. (ashclinicalnews.org)
Activity1
- Antileishmanial activity of amphotericin and other antifungal agents entrapped in liposomes. (ajtmh.org)
Myelosuppressive1
- The principal use of HU has been as a myelosuppressive agent in the myeloproliferative syndromes. (mjhid.org)
Search1
- Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. (springer.com)
Potential1
- Design, synthesis, and testing of potential antisickling agents. (springer.com)
Urine1
- Agents that promote the excretion of urine through their effects on kidney function. (nih.gov)
Cyanate1
- Manning, JM & Acharya, AS 1984, ' The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde ', American Journal of Pediatric Hematology/Oncology , vol. 6, no. 1, pp. 51-54. (elsevier.com)
Properties1
- Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (nih.gov)
Therapies1
- Whilst the treatment paradigms fundamentally vary between different aetiologies, there are overlaps with pharmacological regimes in immunosuppressive agents and anti-platelet therapies. (bvsalud.org)
Study3
- These agents may be continued during the study period. (ichgcp.net)
- However, subjects are not allowed to be started on any of these agents during the study period. (ichgcp.net)
- The present study was carried out with the aim of evaluating the chemical composition and bioactivity of Uvariodendron molundense against Sickle cell disease and associated pathogenic bacteria agents. (scirp.org)
Found2
- A machine for the extracorporeal delivery of covalent anti-sickling agents has been described by Babb and coworkers and this therapeutic modality has been found feasible by others. (unboundmedicine.com)
- 10 ] In addition to its use as an anti-cancer agent, HU has found some marginal applications in dermatology. (mjhid.org)
Blood1
- Xickle ® RBC-Plus™ guards against those agents that can distort red blood cells and cause them to clog blood vesicles and cause pain and organ degeneration and possible organ failure. (xickle.com)
Topic1
- This graph shows the total number of publications written about "Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these publications. (sickkids.ca)
Review2
- To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. (pianolarge.tk)
- Areas covered: We review recent advances in pharmacotherapy for SCD and summarize promising synthetic agents that are in late-stage development (phase 3) for SCD. (readbyqxmd.com)
Development1
- We will continue the development of nitrogen mustards and alkylureas as antisickling agents. (elsevier.com)
Activities1
- The antisickling and antibacterial activities were assessed using Emmel and micro-dilution methods respectively. (scirp.org)
Mechanism1
- The underlying neologismen wirkung viagra mechanism is sparse for taste (primojel) as disintegration agents. (mnscha.org)
Patients3
- Both patients received a patient-specific AruLiteâ„¢ reduced intensity conditioning (RIC) regimen involving melphalan and other agents. (prnewswire.com)
- The management of antithrombotic agents for patients undergoing GI endoscopy. (umassmed.edu)
- In a phase I trial of patients with relapsed/refractory peripheral T-cell lymphoma (PTCL), combining romidepsin and pralatrexate - two agents approved by the U.S. (ashclinicalnews.org)
Method1
- A method for testing synergy with any number of agents. (ajtmh.org)
Publications1
- Below are the most recent publications written about "Antisickling Agents" by people in Profiles. (sickkids.ca)
Prevent1
- Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions. (sickkids.ca)