Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Hemoglobin, Sickle: An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.Erythrocytes, Abnormal: Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Sickle Cell Trait: The condition of being heterozygous for hemoglobin S.Antisickling Agents: Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Lutheran Blood-Group System: A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Dietary Proteins: Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.Placebo Effect: An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Antifoaming Agents: Agents used to prevent the formation of foam or to treat flatulence or bloat.Flavoring Agents: Substances added to foods and medicine to improve the quality of taste.Dictionaries, ChemicalNames: Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.Dentifrices: Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Dental Disinfectants: Chemicals especially for use on instruments to destroy pathogenic organisms. (Boucher, Clinical Dental Terminology, 4th ed)Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Nephrology: A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.Hypericum: Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Phalaris: A plant genus of the family POACEAE.Poaceae: A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.Songbirds: PASSERIFORMES of the suborder, Oscines, in which the flexor tendons of the toes are separate, and the lower syrinx has 4 to 9 pairs of tensor muscles inserted at both ends of the tracheal half rings. They include many commonly recognized birds such as CROWS; FINCHES; robins; SPARROWS; and SWALLOWS.Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.Perylene: A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.History, 19th Century: Time period from 1801 through 1900 of the common era.History, 20th Century: Time period from 1901 through 2000 of the common era.Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Thalassemia: A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gemfibrozil: A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.beta-Thalassemia: A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.Hypolipidemic Agents: Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.ValeratesAnions: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Waste Water: Contaminated water generated as a waste product of human activity.Hong Kong: The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.Hemoglobin SC Disease: One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.Blood Substitutes: Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.Hemoglobin A: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)Hemoglobins, Abnormal: Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Diphosphoglyceric AcidsAspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Hemodilution: Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.

Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. (1/147)

1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore A23187 (2 microM) to rabbit red cells suspended at a haematocrit of 1% in a low potassium solution ([K]0 0.12-0.17 mM) at 37 degrees C. Net movement of K+ was measured using a K+-sensitive electrode placed in the suspension. 3. The concentrations (microM +/- s.d.) of the compounds tested causing 50% inhibition of K+ loss were: quinine, 37 +/- 3; cetiedil, 26 +/- 1; the cetiedil congeners UCL 1269, UCL 1274 and UCL 1495, approximately 150, 8.2 +/- 0.1, 0.92 +/- 0.03 respectively; clotrimazole, 1.2 +/- 0.1; nitrendipine, 3.6 +/- 0.5 and charybdotoxin, 0.015 +/- 0.002. 4. The characteristics of the block suggested that compounds could be placed in two groups. For one set (quinine, cetiedil, and the UCL congeners), the concentration-inhibition curves were steeper (Hill coefficient, nH, > or = 2.7) than for the other (clotrimazole, nitrendipine, charybdotoxin) for which nH approximately 1. 5. Compounds in the first set alone became less active on raising the concentration of K+ in the external solution to 5.4 mM. 6. The rate of K+ loss induced by A23187 slowed in the presence of high concentrations of cetiedil and its analogues, suggesting a use-dependent component to the inhibitory action. This was not seen with clotrimazole. 7. The blocking action of the cetiedil analogue UCL 1274 could not be overcome by an increase in external Ca2+ and its potency was unaltered when K+ loss was induced by the application of Pb2+ (10 microM) rather than by A23187. 8. These results, taken with the findings of others, suggest that agents that block the red cell Ca2+-activated K+ permeability can be placed in two groups with different mechanisms of action. The differences can be explained by supposing that clotrimazole and charybdotoxin act at the outer face of the channel whereas cetiedil and its congeners may block within it, either at or near the K+ binding site that determines the flow of K+.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/147)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/147)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Persistent respiratory effects in survivors of the Bhopal disaster. (4/147)

OBJECTIVE: To examine the role of exposure to the 1984 Bhopal gas leak in the development of persistent obstructive airways disease. DESIGN: Cross sectional survey. SETTING: Bhopal, India. SUBJECTS: Random sample of 454 adults stratified by distance of residence from the Union Carbide plant. MAIN OUTCOME MEASURES: Self reported respiratory symptoms; indices of lung function measured by simple spirometry and adjusted for age, sex, and height according to Indian derived regression equations. RESULTS: Respiratory symptoms were significantly more common and lung function (percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), and FEV1/FEV ratio) was reduced among those reporting exposure to the gas leak. The frequency of symptoms fell as exposure decreased (as estimated by distance lived from the plant), and lung function measurements displayed similar trends. These findings were not wholly accounted for by confounding by smoking or literacy, a measure of socioeconomic status. Lung function measurements were consistently lower in those reporting symptoms. CONCLUSION: Our results suggest that persistent small airways obstruction among survivors of the 1984 disaster may be attributed to gas exposure.  (+info)

The reaction of deoxy-sickle cell hemoglobin with hydroxyurea. (5/147)

In addition to its capacity to increase fetal hemoglobin levels, other mechanisms are implicated in hydroxyurea's ability to provide beneficial effects to patients with sickle cell disease. We hypothesize that the reaction of hemoglobin with hydroxyurea may play a role. It is shown that hydroxyurea reacts with deoxy-sickle cell hemoglobin (Hb) to form methemoglobin (metHb) and nitrosyl hemoglobin (HbNO). The products of the reaction as well as the kinetics are followed by absorption spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. Analysis of the kinetics shows that the reaction can be approximated by a pseudo-first order rate constant of 3.7x10(-4) (1/(s.M)) for the disappearance of deoxy-sickle cell hemoglobin. Further analysis shows that HbNO is formed at an observed average rate of 5.25x10(-5) (1/s), three to four times slower than the rate of formation of metHb. EPR spectroscopy is used to show that the formation of HbNO involves the specific transfer of NO from the NHOH group of hydroxyurea. The potential importance of this reaction is discussed in the context of metHb and HbNO being able to increase the delay time for sickle cell hemoglobin polymerization and HbNO's vasodilating capabilities through conversion to S-nitrosohemoglobin.  (+info)

Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. (6/147)

Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this agent in pediatric patients with sickle cell anemia has not been determined. Children with sickle cell anemia, age 5 to 15 years, were eligible for this multicenter Phase I/II trial. HU was started at 15 mg/kg/d and escalated to 30 mg/kg/d unless the patient experienced laboratory toxicity. Patients were monitored by 2-week visits to assess compliance, toxicity, clinical adverse events, growth parameters, and laboratory efficacy associated with HU treatment. Eighty-four children were enrolled between December 1994 and March 1996. Sixty-eight children reached maximum tolerated dose (MTD) and 52 were treated at MTD for 1 year. Significant hematologic changes included increases in hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, and fetal hemoglobin parameters, and decreases in white blood cell, neutrophil, platelet, and reticulocyte counts. Laboratory toxicities typically were mild, transient, and were reversible upon temporary discontinuation of HU. No life-threatening clinical adverse events occurred and no child experienced growth failure. This Phase I/II trial shows that HU therapy is safe for children with sickle cell anemia when treatment was directed by a pediatric hematologist. HU in children induces similar laboratory changes as in adults. Phase III trials to determine if HU can prevent chronic organ damage in children with sickle cell anemia are warranted.  (+info)

Acetylation of human hemoglobin by methyl acetylphosphate. Evidence of broad regio-selectivity revealed by NMR studies. (7/147)

The development of chemical modification agents that reduce the tendency of sickle hemoglobin (HbS) to aggregate represents an important chemotherapeutic goal. Methyl acetylphosphate (MAP) has been reported to bind to the 2,3-diphosphoglycerate (2,3-DPG) binding site of hemoglobin, where it selectively acetylates residues, resulting in increased solubility of HbS. We have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC and HSQC NMR studies. These spectra of the acetylated hemoglobin adducts showed 10-11 well resolved adduct peaks, indicating that the acetylation was not highly residue specific. The chemical shift pattern observed is in general similar to that obtained recently using [1'-(13)C]aspirin as the acetylating agent (Xu, A. S. L., Macdonald, J. M., Labotka, R. J., and London, R. E. (1999) Biochim. Biophys. Acta 1432, 333-349). Blocking the 2, 3-DPG binding site with inositol hexaphosphate (IHP) resulted in a selective reduction in intensity of adduct resonances, presumably corresponding to residues located in the 2,3-DPG binding cleft. The pattern of residue protection appeared to be identical to that observed in our previous study using IHP and labeled aspirin. Pre-acetylation of hemoglobin using unlabeled MAP, followed by acetylation with [1'-(13)C]aspirin indicated a general protective effect, with the greatest reduction of intensity for resonances corresponding to acetylated residues in the 2,3-DPG binding site. These studies indicated that both MAP and aspirin exhibit similar, although not identical, acetylation profiles and target primarily the betaLys-82 residue in the 2,3-DPG binding site, as well as sites such as betaLys-59 and alphaLys-90, which are not located in the beta-cleft of hemoglobin.  (+info)

Preliminary report of a toxicity study of hydroxyurea in sickle cell disease. French Study Group on Sickle Cell Disease. (8/147)

AIM: To evaluate the tolerance of hydroxyurea in children affected with sickle cell disease. DESIGN: Questionnaire study of French physicians likely to treat patients with sickle cell disease. Data were collected on 101 children with sickle cell disease, treated for a median of 22 months, 36 of whom were treated for more than three years. 13 children were younger than 5 years of age at inclusion. RESULTS: Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus. Acute lymphoblastic leukaemia occurred in a girl treated for 1.5 months with hydroxyurea, this short interval arguing against a causative association. One 17 year old boy had paraparesis after 8 years of treatment. CONCLUSIONS: No major short or medium term toxicity was related to hydroxyurea in this cohort of 101 children. However, the number of children treated for more than 3 years is too few to make firm conclusions on the long term tolerance of this drug.  (+info)

*Nicosan

The established drug hydroxyurea acts in SCD as an antisickling agent, however not all patients respond to this drug and some ... Iyamu E, Turner E, Asakura T (2002). "In vitro effects of NIPRISAN (Nix-0699): a naturally occurring, potent antisickling agent ... Nicosan with possibly less adverse effects also appears to work through "a strong antisickling effect" . It was developed at ...

*Hydroxycarbamide

Antineoplastic Agents - Substances that inhibit or prevent the proliferation of neoplasms. Antisickling Agents - Agents used to ... Due to its chemical properties hydroxyurea was explored as an antisickling agent in the treatment of hematological conditions. ... This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering ... Enzyme Inhibitors - Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme ...

*List of MeSH codes (D16)

... hematologic agents MeSH D27.505.954.502.119 --- anticoagulants MeSH D27.505.954.502.135 --- antisickling agents MeSH D27.505. ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...
Abstract: The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries (LMICs).. This paper outlines conceptual frameworks of three primary stroke prevention strategies: (a) the "polypill" strategy; (b) a "population-wide" strategy; and (c) a "motivational population-wide" strategy.. (a) A polypill containing generic low-dose ingredients of blood pressure and lipid-lowering medications (e.g. candesartan 16 mg, amlodipine 2.5 mg, and rosuvastatin 10 mg) seems a safe and cost-effective approach for primary prevention of stroke and dementia.. (b) A population-wide strategy reducing cardiovascular risk factors in the whole population, regardless of the level of risk is the most effective primary prevention strategy. A motivational population-wide strategy for the modification of health behaviors (e.g. smoking, ...
Buy Hydroxycarbamide (hydroxyurea) 500mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
The Hugs Shirt. The Ferret prefers his hugs bear style not virtual, but the F+R Hugs Shirt is bound to enthuse legions of eager young things anxious for a textile caress. Oh yes. [via the rather delicious We Make Money….]. F+R Hugs is a wearable system that allows to feel the physical closeness of a distant loved one, bringing the pleasant sensation of a hug to body and mind. Is designed to satisfy a desire shared by many people: communicate emotions to distant people we love in a tangible way. Functionallity and use of design: The F+R Hugs system works through a mobile phone network. F+R Hugs shirts receive the input of heart beat, touch and body temperature of the remote loved one, and output it, recreating (through actuators embedded in the shirt) the pulsation, physical pressure, and warmth of a real hug. ...
He also loves to hug and not let go. Hes a good hugger and thats where the Teddy part comes in...like a big ol teddy bear. He is the one who taught me that there are different kinds of hugs. The side hug...for people you dont really want to hug. The back slapping hug....which mocho guys usually do. The close friend and family hug...where your right arm goes over the other persons left shoulder and left arm goes under the other persons right arm. Thats the best hug for squeezing and not letting go. And the awkward hug, unless youre married and like to hug like this...(which I do)...woman hugs mans waist and man loosely wraps his arms around woman. That too is good for squeezing and not letting go ...
Hugs are good for your heart, your blood pressure and your overall health -- just a few of the reasons to hug your loved ones today.
Download the Free Hugs soundtrack here: Sick Puppies New Album Tri-Polar Available Now! http://www.itunes.com/sickpuppies Get your Free Hugs t-shirts here: http://www.bandmerch.com/freehugscampaign...
... hasbeen chosen by the newly married couple to perform your house. arm hug pillow. Along with its style that is modern but nonetheless straightforward, this table been because of several advantages such as could be applied as a way of collecting together a childs learning, your family, a spot so forth and to place the kitchen equipment.
My partner kept suggesting I sleep poor thing he was tired but I kept saying I couldnt...until someone else suggested it of course. My sisters put me on my side and encouraged me to try to sleep between contractions. I did and a few minutes after I felt a thump in my vagina, I got up quick and ran to the foot of the bed. I felt the contractions hug my baby hug every piece of feet , legs...everything...it was both amazing and overwhelming. I was freaking out and started to panic I had never felt this before my womb hugging my semillas body...my womb guiding me telling me where the baby was what my baby was doing....wow! I kept yelling "The babys coming! The babys coming!" In that moment of panic Panquetzani said "Its ok your body will know what to do." I closed my eyes and I felt the baby swim down and slipped into her fathers hands...then I guess she slipped out because I heard a cry and dad was panicking that he dropped the baby....lol thats the last time I trust him to catch a ...
Research activities are an integral part of HUGs mission and is done in close collaboration with the University of Geneva Faculty of Medicine.
This brings me to the point of this post which is something I really need us to pay attention to. I think its about time we start teaching our kids about consent and setting boundaries around themselves or their bodies. When our kids meet family, friends or even strangers for the first time, we usually instruct (for lack of a better word) them to hug or kiss strangers in a bid not to make them seem rude or unfriendly. This is very common, and not unconnected to our culture. Sometimes, we go a bit far by forcing them to do so, even when they are clearly not comfortable with it. ...
Free flashcards to help memorize facts about HUG Chap 2. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
Gainesville Rabbit Rescue Inc. offers the opportunity to serve your community through Want to HUG a BUNNY?!?. This is an ongoing opportunity located in Gainesville, Florida.
Jump Clubb, an anonymous group from Beverly Hills, offer up "A Frozen Hug. Their debut LP The Love Of No Dance is out October 6th.. audio ...
Hug is defined by the Oxford dictionary as to clasp tightly in the arms, especially with affection; embrace. Yet, a simple vocabulary with a simple action
Man, the kids are amazing. I expected to have some smart-alec kids here and there booing us or whatever, but they get right into it. Now I totally understand, because I would have loved a band to come to our school, and its an excuse for them to get out of class. We also get to do a workshop with them afterwards, and they can ask us questions about the industry, and watch us set up and soundcheck, so its a real learning experience. We cant play Im Not A Whore, and we find alternatives for a couple of swear words, but for the most part its really relaxed. The obvious rules are no swearing and always being courteous, although were not allowed to hug the students front-on. We do signings after the show and a lot of the students want a hug, but were only allowed to do side hugs. We thought it was funny, but rules are rules ...
I like hugs to some extent, just so theyre not over the top. Since Mama works from home, she often hugs and kisses me during the day while Im taking my naps. In the evenings, I wait for her to come in the room to play with me. However, I dont always play. Sometimes I just watch the toy and then walk out on both her and the toy to eat some foodies in the kitchen. Other times, after playing, I climb in her lap for a few minutes while she sits on the floor with me. Whatever my mood may be, I wait every night for her to come in and give me some kind of attention. If she works really late, Ill go out to her and let her know Im waiting. Back to the original subject of hugs: do you like them or are you more reserved or do you prefer other means of affection? ...
Surprisingly, part of my discovery in examining how I feel this time around, is that I dont feel any additional pain because we had to also inform family and friends of the miscarriage. This has been my excuse for not informing others during the trial, as I assumed that family would get overly excited at an announcement, and it would only add to my pain to feel responsible for communicating the loss with others. Instead, Ive appreciated everyones texts and prayers. It certainly helped that everyone was very considerate when I said I didnt want to talk those first few days after the second ultrasound. Over all I feel like communicating during this trial may have helped me to feel closer and more grateful for those relationships ...
I was late making moms breakfast and she smarted off to me that she has never been fed this late and thought I wasnt going to feed her at all! She is totally...
Hug a GI Day is for all the men and women who proudly serve for your country. You can give a big hug to all GIs you see today to thank them. If you do not know any GIs show ...
Not sure where Im going with this. When I went to Pixton to try to create something to distract myself, I just kept slapping one thing after another, not sure of what Id come up with. Theres a story there, but Ill probably get back to it much later. Or never. Tuesday, June 6, 2017…
Here is the link: http://www.dailystrength.org/c/Bipolar-Disorder/forum/Crisis-Center/8246624/lastpage Thanks bunches!! Hugs.
Mike had stayed with Isaiah overnight, so I headed down to the hospital early in the morning. When I went to his inpatient room it was empty. I hurried down to the second floor to catch up with them and luckily got there just before they entered the pre-surgical area. For whatever reason, Isaiah was being distant from me and wouldnt give me a hug. I was heartbroken. It was as if I needed him to support me, instead of me supporting him. I knew he was tired and did not grasp the seriousness of the situation, but it was still hard for me to accept that he would not provide me with the affection I so desperately needed at that moment. The anesthesiologist came to examine Isaiah and talk to us. Before I knew it, they were ready to take him away. For all of Isaiahs other procedures I had always been allowed to carry him into the procedure room and stay with him until he drifted off peacefully, like the perfect patient, under the spell of the magical bubblegum-scented anesthetic. This time was ...
Oh no….Emma, my heart goes out to you and Ruggles. Hug each other tightly and please know you did the right thing for Rotley.. ...
I am trying to get the div to hug the image, it seems that the vertical side of the DIV do, but the horizontial edges dont. I have tried different things. and I cant seem to get rid of the white space. My only other option is to use position and set everything static on the page, I really dont want to do that .. I just want the little white spaces gone. Anyone have any suggestions? Here is a link to my page cconway.com/v5 Thanx Chuck
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 26
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 38
My child has fine motor issues, cannot ride a bike with training wheels at age 5, Is constantly touching things. Hugs constantly and impulsively, does
Thursday night I was finally able to land a date with a very attractive woman I met a few weeks before. All went well -dinner, club, dancing, light nightcaps- then came the pivotal moment of every first date. Go for the kiss or hug?
Sickle cell anemia is a genetic disorder that affects blood and necessitates frequent blood transfusions in certain cases. Test your knowledge on sickle cell anemia by taking this quiz.
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
Got a question about sickle cell anemia? Text it to 646464 (OHOHOH). --- There is good news on the horizon in sickle cell research. Researchers at The Childrens Hospital of Philadelphia (CHOP) are exploring a number of ways to stop the disease in its tracks and develop treatment option...
Free essay examples, how to write essay on Sickle Cell Anemia 3 example essay, research paper, custom writing. Write my essay on sickle cell blood.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Find out more about enrolling in GlycoMimetics Phase 3 trial for rivipansel for the treatment of vaso-occlusive crisis in sickle cell disease patients.
Cohen and his team chose to study hugging as an example of social support because hugs are typically a marker of having a more intimate and close relationship with another person. "We know that people experiencing ongoing conflicts with others are less able to fight off cold viruses. We also know that people who report having social support are partly protected from the effects of stress on psychological states, such as depression and anxiety," said Cohen. "We tested whether perceptions of social support are equally effective in protecting us from stress-induced susceptibility to infection and also whether receiving hugs might partially account for those feelings of support and themselves protect a person against infection." In 404 healthy adults, perceived support was assessed by a questionnaire, and frequencies of interpersonal conflicts and receiving hugs were derived from telephone interviews conducted on 14 consecutive evenings. Then, the participants were intentionally exposed to a common ...
What are the different types of therapy hugs, long hugs, short hugs, A frame hugs, sexual hugs, bear hugs, stealth hug, epic fail hug etc.
This Hugs & Drugs Tank Top is printed on a Tank Top and designed by t-shirt. Available in many sizes and colours. Buy your own Tank Top with a Hugs & Drugs design at Spreadshirt, your custom t-shirt printing platform!
Donation Helps to Fund 25 Bottle Schools in Latin America INDIACSR News Network Plano, TX : WorldVentures Foundation™, the philanthropic arm of WorldVentures™, the leading direct seller of vacation club memberships, said that it has raised and donated over $100,000 to Hug It Forward, a grass-roots organization that facilitates education and awareness by empowering communities to build schools using "eco-bricks." Because of the efforts of WorldVentures Independent Representatives, Hug It Forward is now able to develop eight new schools in Guatemala. Since October 2009, the organization has completed 25 successful bottle school projects, at an average cost of $6,500 per classroom.. "We are extremely proud of our Independent Representatives donating to the WorldVentures Foundation for such a worthy cause as education, live at our biggest training event of the year," WorldVentures Co-Founder and Chief Visionary Officer Wayne Nugent said. "Our Representatives and DreamTrips™ Members have ...
The last one is called the Super-Long-Oh-So-Passionate Hug. This is similar to the bear hug but it lasts longer and you cling to your loved one for several minutes, or even hours if you can handle it. I could just imagine myself doing this if I havent seen someone for a long long time. Sometimes when you miss the person you love, this is one way to show how much youve missed him. Do not do this with a person youre not in a relationship with or else it will really feel awkward or worse, embarrassing. ...
Start of a 2nd date, kiss on cheek, lips or just hug? At the start of a 2nd date (if you havent kissed yet) but want to show you are interested and like them what is the best thing to do? Hug them, Kiss on the...... asked under Dating
[ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:Hydroxyurea | DROXIA | HYDREA, Synonyms:HYDROXYUREA | HYDROXYCARBAMIDE | DROXIA | HYDREA | SQ 1089 | SQ-1089
Cheap hydroxyurea fast delivery, Price hydroxyurea indicacao, Purchase now hydroxyurea visa usa, Generic hydroxyurea hydroxyurea stl
Kid hug heart Vector. csp8444425 - Little kid hugging a big heart. Affordable Royalty Free Stock Photography. Downloads for just $2.50, with thousands of images added daily. Subscriptions available for just $39.00. Our stock photo image search engine contains royalty free photos, vector clip art images, clipart illustrations.
Tim Harris, owner of Tims Place, is the countrys only restaurant owner with Downs Syndrome, and the joy he gets from serving people good food carries over into his diners most famous export: hugs.
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
Attorney Mike Horton was living with a potentially deadly abdominal aortic aneurysm. Lucky for him, his wife gave him a hug and found the pu
(AP) -- A 51-year-old Ohio man has embraced the Valentines Day spirit faster than anyone before, giving 7,777 hugs in 24 hours for a new world record.
So, getting back to Bessie. Bessie has now been upgraded to Bruno. Bruno also incorporates "trigger points.". See the difference? This guy is oh-so-very much more…uh…specific. I could use this to my advantage.. Given how most chronic illnesses are like a box of chocolates…you neva know what youre gonna get…on any given Sunday I can now present a list.. A list of, "Short Loin is out of service today. Please do not touch.". Or…"Touch #2 on the Foreshank and Brisket and you die.". So, yes…it stands to reason that hugs most certainly DO hurt. Do I stop giving hugs?. NO. The physical discomfort cannot replace the emotional comfort created by getting/giving a hug.. BUT…I thought it might be beneficial to the community at large that if I were to, say…decline…a hug…that it in no way is to be considered an affront to you.. Better yet…if you are aware that the person you wish to wrap your arms around is a chronic badass…open your arms wide and wait for us to wrap around ...
Brad Stokes is sure that he can change the world with a hug.. And if it sounds like a big challenge, he is not only willing to prove it to one person, but to thousands.. Stokes - one member of the four-person Kindness Crew - demonstrated his passion for his goal to students Wednesday morning at Queneesh Elementary School as part of the Extreme Kindness Crew touring 11 Comox Valley schools this week.. Stokes is in the middle of attempting to speak to 10,000 students prior to Christmas about the value of kindness in hopes to inspire students to create their own acts of kindness towards each other and their communities.. "Random acts of extreme kindness is something you like to do while making a positive impact on the community," he said.. The Kindness Crew also includes Val Litwin, Erik Hanson and Chris Bratseth; four friends who, motivated by the 9/11 attacks, travel the world promoting kindness "to make the community a better place, and in turn, it makes you happier and healthier," noted ...
Download this Little Girl Hugs A Rabbit photo now. And search more of the webs best library of royalty-free stock images from iStock.
Level Halo. Hug the right wall out of the ship. Just in the entrance of the cave, to the right theres a smaller cave that holds this skull.
Usually ships in 3-5 business days. Amoeba hugs, you know, are often fatal. Show your love of amoebas and phagocytosis with this oh-so-fashionable pillow. • 18
Objective: Apoptosis plays a dominant role in both spontaneous spermatogenesis and germ cell death. This study was aimed to investigate the functions of relate...
Ordering Hydroxyurea - No Rx Cheap! No Rx Hydroxyurea Fed Ex! Trusted Online drug-store - Hydroxyurea http://boys-here.com/promo/aculmbnr6.jpg Buy this medicine to your country. Hydroxyurea - Buy Hydroxyurea Now! Click Here!
Hello, Thanks for your thanks, very kind comments, the cyber-hug and the donation to the Robert James Frascino AIDS Foundation. All are warmly appreciated. Im delighted you too have found your...
Archie is just as disappointed and confused as I am. And of course, Jack went to all these appointments with me and knew that the bloodwork today was to see if there were any babies growing in my tummy. So when we picked him up from school, and I was upset, he wanted to know why. I was on the phone with my mom and she was upset that I told him how I did, but he needs to know. He knew that we had put babies back in there, the logical question is what happened to them? So he asked and I told him that I was upset because there werent any babies in my tummy and that meant that we had more time for us to have him all to himself. He was fine with that and gave me hugs and kisses. Then a little later he asked me where the babies went. I explained that they went to heaven because God was ready for them. He asked how they got there, and I told him that it was like God gave them a big hug and just wrapped them up in His arms. He asked me if it was like a sliding star that slid up to heaven from earth, ...
Now, for most people, pain killers are a non-issue, but somebody who has a history of substance abuse needs to be careful. I used to smoke so much pot that I couldnt even get high anymore. I was doing about an ounce a week of the strong stuff. I ate carbs til I passed out, sick, eating myself to a morbidly obese 306 lbs. Alcohol was never really a problem for me, but I could see how it could quickly become one, based on my history ...
To my friend Amber who was with me yesterday, I know how much your husband loves you. I have to say, I love you too. You were amazing and supportive and kept me sane during a traumatic day. I will never ever forget what you did for me yesterday and if I can do anything for you (after of course, kicking cancer to the curb), I am there. You transcended to not just a close friend but truly a sister to me yesterday. *Interwebs high five* You even got a hug from my sweetie yesterday. Ive never seen him hug anybody else. Count him as a fan of yours, as well ...
BETHEL - The third annual Team Hailey Hugs walk-a-thon took place on Saturday at Crescent Park elementary school in Bethel, with the turnout this year better than ever, and so were the donations. Team Hailey Hugs was created by the Steward family of Bethel, and some of their friends, in honor of their daughter, Hailey…
I am very thankful for my big girl Makenna. She is a handful also. She is hitting the threes early I think. She causes me the most trouble. She can be the sweetest, most lovable girl and then a second later, she is a hellion! I just dont know what to do with her sometimes. I have tried so many different ways of punishing her and nothing seems to work. I guess I just have to stick to one and go with it. She gave us our biggest scare yet a couple months ago. I am sure I will have many more scares like that in the future with any of them, but I pray it is not any time soon and it turns out better than worse. The worst feeling in the world is to know your child is hurting, or very sick and there is nothing you can do about it. I love her hugs, they are the best hugs in the world! She is definitely a mommas girl...most of the time. She is still very very shy, but once she warms up to you, she is so much fun ...
This will be the last page Ill publish before I take a break (Im getting out of Dodge, too) until Monday, August 8th. There wont be a Daily News Post until then as well. Ill be baaccckkk! Lin/Linda... We all need hugs but sometimes there just isnt anyone handy. We CAN hug ourselves.
Q10 Natural Complex je proizvod sa 10 aktivnih sastojaka, formuliran na bazi visoke doze koenzima Q10 te sinergije prirodnih izvora vitamina C, vitamina E, ekstrakata cikle i češnjaka. Proizvod je dodatno poboljšan vitaminima B skupine, između ostalog sa vitaminom B1 koji doprinosi normalnoj funkciji srca, vitaminima B6 i B12 koji doprinose normalnom metabolizmu stvaranja energije.
This happened at a party I attended recently. I was curious as to how someone else would handle the situation. The backstory is this. I live in an area known for a specific industry that involves a large number of
No, for real! See? Amazing, right? Activisions indie competition, I think, follows a similar pattern - except with slightly fewer kittens and tremendously less
A place to learn about depression, natural depression cures, natural depression remedies, medical depression cures, and medical depression remedies.
Sleeping in a room with no windows can certainly throw your sense of time off a wee bit. However, Brown Eyed Soul managed to rouse me out of my deep slumber to the tell-tale sounds of other guests getting ready to attack their morning. Apprentice was still enjoying her sleep despite my shuffling all around…
Maia Gough looked like a little angel when she took the stage. But this 12-year-old is more than just sweet, she is one AMAZING singer. When she started belting Whitney Houstons I Have Nothing my jaw dropped, and it looks like I wasnt alone!
Throwing his arms around Indias Prime Minister, Japanese Prime Minister Abe marked a sharp contrast from the firm handshake with which he greeted U.S. president Obama in April.
New data intensifies interest in hydroxyurea.: Newly publicized trial data are showing that hydroxyurea has strong anti-HIV activity, especially when combined w
My 2nd child is due April 1st. I had a rough time with supply 1st time around, I EP for 9.5 months 45 min sessions but that was nov 09- july 10, used Fenugreek and I have a medela freestyle. Are the Hospital pumps better that you can rent? Is there anything other than drinking enough water to boost supply before the next one arrives. With a toddler I just wont have the extra time to give to pumping as I did last time. Please give me some suggestions. Thank You :hug
Babys naps will become something special with this ultra-soft blankie! GUNDs patented Comfy Cozy design combines the coziness of a baby blanket with animal plush accents (head and paws) for increased huggability and play value. Winky the Lamb Comfy Cozy is another quality GUND product who is know for using premium materials for unparalleled softness and hug ability ...
OK NICU nurse intervening here. UM You are doing a FABULOUS job as a mother of a NICU baby. You cant be in there 24/7 and still take care of yourself, which you need to do to be able to care for your son when you are there. People who make comments about something they know little about really need to back off. Ive been a NICU nurse for 15 years and NEVER have I seen a mom or dad stay 24/7 and be able to function. We usually send them home to care for themselves. Im so sorry youre having to put up with people who are ignorant of how much of a toll this has taken on you as a new mom. Im sending you all the hugs in the world dear and letting you know, I KNOW youre a wonderful mom doing WONDERFUL things for your son in the most extreme of unusual circumstances.. ReplyDelete ...
Bobbie had to go and get the doctor so he could talk to me. My doctor was out for the day, so it was a doctor I had never seen before. He had to give me the news, no one ever wants to hear. He came in the room and immediately said Im so sorry. He gave me a HUG! That was the moment I broke down. He handed me the tissue box. I tried to stay as calm as I could do I could listen to the words that were coming out of his mouth. He explained why she would be able to make it, he asked if I wanted my husband here there with me. Then he asked if I would like to abort, a lot of women do when they know their babies wont make it. He asked if I would do an amniocentesis. I didnt have any answers. So I left ...
The Cancer Center meets the needs of patients affected by cancer. It coordinates all the HUG stakeholders to ensure the best care for cancer.
Shakey, My heart goes out to you ...big hugs to you. I have had many pets over the years. My dog senses many things about me. Recently Ive been keeping him off the bed, as my nerve pain is so bad. He often finds a way when my BP is too low and lays on me as if it gives me more pressure. The other day he got caught up on my iv line and my port line got torn out. We were both traumatized. No more dog on the bed anymore. Sometimes I feel like I should give him away, so he could have a life where he could be taken out to run and run. He also has a Neuro disorder. I have cried and as he has seized for 15 mins at a time in my arms. Thinking each time this will be the last time. I see him so loving, yet fearful at times. Living with a chronic illness is hard, even in a pet it is so sad to watch. I often see myself in my dog, I wish he could talk and tell me more that was going on so could make life easier for both of us. Maybe, it is why we ended up together.... I think we needed each other. We paean ...
A friend forwarded me a link to this recent Daily Mail* story about a ridiculously cute little lad with PWS. (*Obligatory warning: Its The Mail. Do not, under any circumstances, look at the comments). Yes, this article is what sparked my EAT themselves to DEATH ramblings. Its sensationalised of course. Buried near the end is a quote from the boys mum: "Michelle, who works as a part-time nurse, added: With the continued research in genetics and PWS, we remain positive about the future and hope that our little boy will be able to lead a happy and healthy life." This was immediately followed by four bullet-point examples showing bizarre and frightening examples of the very worst aspects of the syndrome, which in juxtaposition was like having a hug and then being slapped ...
He screamed for about an hour, and nothing would help. He told me his throat hurt, that his tongue hurt, and that he wanted his cup. It was too early for more medication, so I tried to soothe him on the sofa with his sippy cup and beloved "black bear." He simply couldnt settle, alternately yelling for "Dad" or his cup. He would also reach for me, grab me in a hug, and wail, "Want wuv!" I gave him all the "wuv" I could, but he wanted down and went upstairs. Dennis picked him up and he kept wailing "Dad!" We finally realized he wanted "bed." He felt awful, but he wanted to lie in his own bed with his sippy cup and his bear. We tucked him in, and he fell asleep, exhausted from his 2 hour long scream-fest ...
Ull be sick to death (hmmmm maybe that wasnt the best way to phrase that) but ya know what i mean....Uve got to "Stay Positive" sometimes its not possible but ya have got to fight back to retain it. It was the only way i could change things, when ur down theres only one way u can go & thats up! So it was me adopting this Postive Attitude that I got up again & refuse to go down no-matter how bad it gets......its not easy but when u have no other answers its all ya can do......so hun u will get through this "Some How, No Matter What" ! Actually i have longer periods of well being than i had, so it has its benefits ! Sure uve got us.......lol:D Hugs again :)x yeah i agree, having a positive attitude does help! and it does suck, i have had so many friends and loved ones pass from things worse than i have. my hubby for example, that was a time where i had somebody to actually care for me when i was sick. it really does suck.... having something that almost no doctor knows about. some days i puke ...
Oh dear lady, what a trial! It just sucks that you had to go through all this, and Im very glad you are well. My husband had cancer of the the thyroid - hes been on synthroid for many years now and just fine. Sending back oodles of hugs to you! Im still technically vacating, but I am secretly snooping my bloggy buddy blogs, and had to leave you a comment. xoxo. ReplyDelete ...
This is what I got from her: this is a medical facility where sick people come to get better( I guess she means the hospital as well..who the hell knows)..and when people come to the office they dont want to hear us burping, belching..that doesnt look good for us..Maybe you can find a place where its quiet( she said go to another office) and your not around many people. I know its not your fault that your burping and belching..its doesnt look good for the this office, because we are here to help people get better( I mean they see Employee ONLY and half of them I know and know Im not well..I havent been well since November, HELLO) Well see you when you get back. She WOULD NOT let me stay there...I had another hour...it was only 11 o clock...she at least could have allowed me to stay till 12...when Im done, but no...All I got was a hug and good bye well see you when you get back.. She didnt wish me luck, didnt say, oh, keep in touch and let us know what happened....Well see about that ...
Gail: I am sure that we can get the PCE all fired up. I am ready for a trip (having the 3 grandkids home all day now that school is out will drive a old nana nuttier than she is..lol). I get tired of the tests also. I was due for a ct, MRI and PET scan last month. I told my onco that I didnt want to have them done right then. The idiot nurse scheduled them all in one day! Anyway, at my last treatment they asked if they "could" schedule them again. I said not right now. Tired of tests. Just want to enjoy a little longer knowing that everything is clear. (all of my bloodwork is ok so Im not worried) Hang in there. I am sure that nothing but arthritis will show up. But, as we all know, better safe than sorry.. Hugs....Deb. ...
Oh I met Sam and his sibs last year and saw how devoted you all were to each other - especially Sam and you. Oreo, I understand your sadness; it is always a hard time when our near and dear start to slip away from us. You are being a great furiend, holding Sams paw in this difficult time. Sending POTP to you for your heart and to Sam that he suffers not too much. Hugs and wags, YAM-aunty xxx. ReplyDelete ...
Hi Jo! Hope life is treating you fine!:) Your insta-pics are always very lovely and for me interesting to check out everytime, you had an adorable account. Btw, Pasarbella sounds so good, that Nutella crepe inspires me a lot!:) I remember those cupcakes made from u and all the story about them, till now they make me watering, yum!:) Btw, Im sorry rained a lot and you had to cancel your plan, had a bad Sun even here, pouring down and so dull! I got a headache so I rest all the day. How thrilling is ur bday week! Will be careful to notice when the day is to make u the wishes then!:) Have a great week ahead dear Jo, hugs! xo. ReplyDelete ...
I know how that feels. In the end, the only thing that worked for me was to plan, plan, plan.....shake up the routine. Just DO rather than allow yourself to think - especially when you get the urge to drink. It also didnt work for me, when I did the same as you - ask other people what THEY thought. My husband said the same thing as your kids, and in the end, i realised that I was just asking him for permission ...and it wasnt fair to him. Maybe rather than beat yourself up, take a look at the pattern of the weekends? Try to find a way to shake it up a bit? Hugs xxxx. ReplyDelete ...
Hello. This post is likeable, and your blog is very interesting, congratulations :-). I will add in my blogroll =). If possible gives a last there on my blog, it is about the Placa de Vídeo, I hope you enjoy. The address is http://placa-de-video.blogspot.com. A hug. ...
Hello. This post is likeable, and your blog is very interesting, congratulations :-). I will add in my blogroll =). If possible gives a last there on my blog, it is about the Placa de Vídeo, I hope you enjoy. The address is http://placa-de-video.blogspot.com. A hug. ...
Warning: theres some talk of sex and rape down the page a bit, after I start talking about BF. Feel free to skip it if it might trigger you.Im hurting today. I feel sad and alone, and I just want a hug. I think its the combination of being sick, the aftermath of Mothers Day,…
Hi Ann, well to say the least it sucks! Sadly I know how ya feel. All though I dont suffer from the same things you have I do suffer from the lack of physicians to help out. It took me 4 months to get an appt to see a rheumy. Than after I saw him I waited two weeks for him to send the paper work to my pcp and than the nurse called and said My pcp wants to see me because she doesnt beleive what the rheumy said was wrong with me!!!!!!! Im like you I dont know any doctors by their first name or have money to grease a palm with . Its so utterly frustrating somtimes. I didnt understand the one thing you mentioned though. I couldnt figure out why the doctor doesnt want you sister to come be with you? Take a deep breath and try not to break anything. Hopfully you can get a little somthing to get you through until Jan. hugs. ...
Today I would like to introduce my new Kill Team: The Zoats. Not much is known these days about this xenos race. I focused on the part of their lore regarding their supposed enslavement by the Tyranids. The question now is, how the Tyranids would be able to do so. Thus I came up with a whole new-made up unit, the Cephalotrophs. The Cephalotrophs are a small, floating breed of Tyranids who have quite a fragile body which mainly is a gland plus a little tail. While on the hunt their chitin scale is used to protect them but as soon as they find a possible host they try to hug them from behind. Flesh hooks are fired .... ...
Amy, what a beautiful inviting shop. Oh how I would love to come and Im so happy it was a super success---how could it not be with your positive energy. I finally gave into the shots and epedurams and I dont regret it---keeping me off schedule 3 drugs so far and surgery. Hope you feel better soon. Rest that back---it could be just over worked. Love and Hugs, Pat ...
REALITY IS LIKE A STONE. TO MANY IT S HARD AND COLD, THEY CAN T HUG IT OR EAT IT, IT ONLY FRUSTERATES THEM AND DOESN T DO THEM MUCH GOOD. TO OTHERS IT S STRONG AND DEPENDABLE, YOU CAN BUILD WITH IT, BUILD UPON IT, OR WORK WITH IT, ALSO USE IT TO SMASH PEOPLE IN THE FACE. ...
I made this card with the NEW MFT Pure Innocence Costumed Cuties VIP Kit! This is the NEW Prehistoric Girl and Owl Costume stamps sets and the NEW Peek-A-Boo Die-namics...the kits go fast so check out my blog for all the details for the VIP kit! http://inkingontheedge.blogspot.ca/2...innocence.html TFL! Hugs,t
PD parameters were obtained after a standardized schedule of hydroxyurea dose escalation to MTD as previously described.2,13 Importantly, dose escalation to MTD for HUSTLE was performed by experienced health care providers who were masked to any knowledge about first-dose PK data. At MTD, both the average %HbF response and the average hydroxyurea dose were almost identical between the New and Old Cohort subjects and were similar to previously published data for children with SCA at hydroxyurea MTD.1,4,5 Predictors of the hydroxyurea treatment response, particularly the %HbF, have been previously proposed; in the original phase 1/2 trial for adults with SCA, the best HbF responses occurred in subjects with higher baseline HbF and baseline WBC count.5 In the phase 3 MSH study the best responses occurred in adults with higher baseline ANC and ARC, as well as those with greater treatment-associated changes in ANC and MCV, but baseline HbF was not predictive.35 In the phase 1/2 trial for school-aged ...
Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop.. To determine the sensitivity and specificity of transcranial Doppler in detecting significant (greater than or equal to 50% lumen diameter reduction) intracranial arterial lesions, we compared transcranial Doppler and cerebral angiography in a primarily young, symptomatic group of 33 patients (18 males and 15 females) with sickle cell disease.. From a total of 34 examinations, transcranial Doppler detected significant abnormalities in 26 of 29 (sensitivity 90%, specificity 100%). Five were normal by both techniques. The transorbital examination detected abnormalities in two patients whose studies were otherwise unremarkable.. Transcranial Doppler is sensitive and specific for the detection of arterial vasculopathy ...
The Stroke Prevention Trial in Sickle Cell Anemia (STOP) was a randomized trial to evaluate whether chronic transfusion could prevent initial stroke in children with sickle-cell anemia at high risk as determined by transcranial Doppler (TCD). The trial demonstrated a large benefit of transfusion and was halted early. After termination of the trial, patients participated in a post-trial follow-up study. More patients in the transfusion group (70%) elected transfusion for primary stroke prevention compared with those on standard care (45%).
Treatment of Sickle cell anemia is an inherited form of anemia - a condition in which there arent enough healthy red blood cells to carry oxygen throughout your body, Under normal circumstances, your red blood cells are flexible and round, and they move easily through your blood vessels to carry oxygen to all parts of your body. In people with sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons, These irregular-shaped blood cells die prematurely, resulting in a chronic shortage of red blood cells. Plus, they can get stuck when traveling through small blood vessels, which can slow or block blood flow and oxygen to certain parts of the body. This produces pain and can lead to the serious complications of sickle cell anemia, Theres no cure for most people with sickle cell anemia. However, treatments can relieve pain and prevent further problems associated with sickle cell anemia, Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Anemia Symptoms
TY - JOUR. T1 - Effects of hydroxyurea treatment for patients with hemoglobin SC disease. AU - Luchtman-Jones, Lori. AU - Pressel, Sara. AU - Hilliard, Lee. AU - Brown, R. Clark. AU - Smith, Mary G.. AU - Thompson, Alexis A.. AU - Lee, Margaret T.. AU - Rothman, Jennifer. AU - Rogers, Zora R.. AU - Owen, William. AU - Imran, Hamayun. AU - Thornburg, Courtney. AU - Kwiatkowski, Janet L.. AU - Aygun, Banu. AU - Nelson, Stephen. AU - Roberts, Carla. AU - Gauger, Cynthia. AU - Piccone, Connie. AU - Kalfa, Theodosia. AU - Alvarez, Ofelia. AU - Hassell, Kathryn. AU - Davis, Barry R.. AU - Ware, Russell E.. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β0-thalassemia genotypes, many patients with HbSC experience severe disease complications, including vaso-occlusive pain, acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the ...
Patients with sickle cell anemia often require blood transfusion as part of the treatment for their disease. Since each teaspoon of packed red blood cells contains about 5 mg of iron and humans have no way to get rid of excess iron, the levels of iron in sickle cell patients increase rapidly with each transfusion. Too much iron is extremely dangerous and causes damage to blood vessels, red blood cells, liver, hormone producing glands and heart. It is very difficult to know what damage due to iron overload in sickle cell patients because the sickle cell disease itself causes organ damage to the same organs affected by iron.. The purpose of this project is to demonstrate that iron overload significantly increases the morbidity of sickle cell disease and that treatment of the iron overload with Exjade® prevents or attenuates iron-related morbidity. To accomplish this we will screen sickle cell patients with a history of many blood transfusions to see if they have high iron levels. Then we will ...
Review question We reviewed the evidence about the effect of giving vitamin D supplements to people with sickle cell disease.. Background Sickle cell disease is an inherited red blood cell disorder affecting millions of people worldwide. In sickle cell disease, the red blood cells become crescent-shaped and hard so that they block small blood vessels resulting in a lack of oxygen supplied to tissues and organs. This blockage causes episodes of pain, short-term and long-term organ damage, acute chest syndrome and stroke. Sickle cell disease can also lead to bone complications in both the short and long term. Pain and musculoskeletal complications are the most common reasons for people with sickle cell disease seeking medical treatment; even though they do not greatly contribute to mortality, they remain an important cause of illness in the short and long term.. Vitamin D deficiency is common in people with sickle cell disease regardless of age and season. Since vitamin D regulates calcium levels ...
Review question We reviewed the effectiveness of blood transfusions, simple and exchange, for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care. This is an update of a Cochrane review first published in 2010.. Background Sickle cell disease is an inherited blood condition affecting over 250 million people worldwide and is particularly common in Sub-Saharan Africa, South and Central America, Saudi Arabia, India and a number of Mediterranean countries. It is characterised by the presence of sickle-shaped red blood cells which are capable of blocking the blood vessels causing pain and severe damage to several organs of the body. People with sickle cell disease may have the acute onset of chest problems which may include fever, this is called acute chest syndrome. It may have several different causes which include infection and blockage of blood vessels. Fever, coughing, shortness of breath which are accompanied with chest pain are the ...
In polycythemia vera (PV) and essential thrombocythemia (ET) the discovery of the presence of JAK2V617F mutations indicates that tyrosine kinase activation is a common pathogenetic mechanism in Ph- MPD.1 The main therapeutic goal is to diminish the risk of clinical complications without increasing the risk of the development of myelofibrosis or acute leukemia. Hydroxyurea (HU) is widely used as a first line myelosuppressive therapy for patients with PV and ET.2,3 The control of the thrombocytosis is usually rapid and effective with initial treatment with HU,2 but the effect upon the JAK2V617F allele burden has not been studied. The JAK2V617F expression has been shown to decrease with IFN therapy and in some patients the mutated clone even seems to be eradicated.4 The aim of this study was to investigate the JAK2V617F response of HU treatment in newly diagnosed patients with PV or ET. Nine patients with PV and 9 with ET positive for JAK2V617F with high risk MPD3 and need for myelosuppressive ...
Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.. Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.. The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia. ...

D Category Names List - Drug Information Portal - U.S. National Library of MedicineD Category Names List - Drug Information Portal - U.S. National Library of Medicine

Desickling Agents (0) see Antisickling Agents. Designer Drug (1). Detergents (31) • Purifying or cleansing agents, usually ... Defoaming Agents (0) see Antifoaming Agents. Defoliants, Chemical (3) • Herbicides that remove leaves from trees and growing ... Dopamine Agents (151) • Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on ... Dermatologic Agents (125) • Drugs used to treat or prevent skin disorders or for the routine care of skin. MeSH ...
more infohttps://druginfo.nlm.nih.gov/drugportal/drug/categories/d

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects T. Kassa, M. ... Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects ...
more infohttps://pubs.rsc.org/en/Content/ArticleLanding/MT/2017/C7MT00104E

Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood JournalBeyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood Journal

Hemoglobin modification and antisickling agents. Carbon monoxide (CO) is a potent antisickling agent, because it attaches to Hb ... Induction of HbF and antisickling agents. Irreversible sickling does not appear to be the driving factor for red cell adhesion ... Drugs that increase HbF levels are the archetypal antisickling agents, because HbF interferes with polymerization of HbS, ... Anticoagulants and antiplatelet agents. Although coagulation is chronically activated in SCD,79⇓⇓⇓-83 no specific clinical ...
more infohttp://www.bloodjournal.org/content/127/7/810?sso-checked=true

Health information and publications in Africa African Index Medicus DatabaseHealth information and publications in Africa African Index Medicus Database

Antisickling Agents Add the result to your basket Refine your search Generate the RSS feed of the search. Antisickling ... Antisickling Agents Anemia, Sickle Cell Carica Sorghum Nigeria. Abstract: The antisickling properties of fermented mixture of ... Antisickling Agents Anemia, Sickle Cell Carica Sorghum Nigeria. Abstract: The antisickling properties of fermented mixture of ... Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench [] / C. O. C. Mojisola ...
more infohttp://indexmedicus.afro.who.int/aim/opac_css/index.php?lvl=more_results&mode=keyword&user_query=Antisickling+Agents&tags=ok

A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable...A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable...

Antisickling Agents. Additional relevant MeSH terms: Anemia, Sickle Cell. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. ... ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01597401?recr=Open&cond=%22Anemia%2C+Sickle+Cell%22&rank=14

Hydroxyurea Management in Kids: Intensive Versus Stable Dosage Strategies - Full Text View - ClinicalTrials.govHydroxyurea Management in Kids: Intensive Versus Stable Dosage Strategies - Full Text View - ClinicalTrials.gov

Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ...
more infohttps://www.clinicaltrials.gov/ct2/show/study/NCT03020615

Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET...Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET...

Antiviral Agents. Anti-Infective Agents. Immunologic Factors. Physiological Effects of Drugs. Antisickling Agents. Enzyme ... At present the chemotherapeutic agent hydroxyurea is the standard of care for high risk patients with PV. Concern exists about ...
more infohttps://clinicaltrials.gov/ct2/show/study/NCT01259856?show_locs=Y

Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes - Full Text View - ClinicalTrials.govStudy of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes - Full Text View - ClinicalTrials.gov

Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ... No treatment with any other antisickling agents within the past 4 months Biologic therapy: No transfusion within 90 days No ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00004404?term=Clotrimazole&

Biochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st EditionBiochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st Edition

Dichloromethane as an Antisickling Agent in Sickle Cell Hemoglobin. Fourier Transform Infrared Spectroscopy of Hemoglobin. A ...
more infohttps://www.elsevier.com/books/biochemical-and-clinical-aspects-of-hemoglobin-abnormalities/caughey/978-0-12-164350-8

Dr. John Reed, MD - Greenville, NC - Nephrology | Healthgrades.comDr. John Reed, MD - Greenville, NC - Nephrology | Healthgrades.com

A Single Dose Pharmacokinetic Study of the Antisickling Agent Cetiedil, 1983. *Nutrition and Sickle Cell Disease, 1986 ...
more infohttps://www.healthgrades.com/physician/dr-john-reed-xr5ht

Chemical Fingerprint and Anti-Sickling  Activity of Rosmarinic Acid and Methanolic Extracts from Three Species of Ocimum from...Chemical Fingerprint and Anti-Sickling Activity of Rosmarinic Acid and Methanolic Extracts from Three Species of Ocimum from...

The antisickling activity order is the same as that of the rosmarinic acid content, indicating that this polyphenolic acid ... Methanolic extracts of these three species and pure rosmarinic acid showed significant antisickling activities with minimal ... from Democratic Republic of Congo and to compare their antisickling activity of that of rosmarinic acid, the major compound to ... Mehanna, A.S. (2001) Sickle Cell Anaemia and Antisickling Agents Then and Now. Current Medicinal Chemistry, 8, 79-88. http://dx ...
more infohttps://scirp.org/journal/paperinformation.aspx?paperid=62755

WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...

Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues. Abraham, D.J., Mehanna, A.S., ... Agents Chemother. (1998) [Pubmed]. *Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic ... Modification by pharmacologic agents. Castor, C.W. Arthritis Rheum. (1975) [Pubmed]. *Oxidative stress and Mrp2 internalization ... inhibitory concentration values ranging from 0.3 to 6.0 microM and has been shown to restore sensitivity to alkylating agents ...
more infohttps://www.wikigenes.org/e/chem/e/3278.html

Anti-sickling Herbs | SpringerLinkAnti-sickling Herbs | SpringerLink

Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. Pharmacogn Rev 7(13):53-60PubMed ... Soforowa EA (1975) Isolation and characterization of an anti-sickling agent from Fagara zanthoxyloides. Lloydia 38:169-171 ... Adesanya SA, Idowu TB, Elujoba AA (1988) Anti-sickling activity of Adansonia digitata. Planta Med 54(4):374PubMedGoogle Scholar ... Mojisola OC, Adebolu EA, Alani DM (2008) Anti-sickling properties of Carica papaya Linn. J Nat Prod 1:56-66Google Scholar ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-030-04408-4_12

Sickle Cell Anemia | Grand Strand HealthSickle Cell Anemia | Grand Strand Health

Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
more infohttps://grandstrandmed.com/hl/?/11561/

Sickle Cell Anemia | Doctors HospitalSickle Cell Anemia | Doctors Hospital

Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
more infohttps://doctors-hospital.net/hl/?/11561/sickle-cell-anemia&com.dotmarketing.htmlpage.language=1

The American Journal of Tropical Medicine and Hygiene | In Vitro Activity of Artemisinin in Combination with Clotrimazole or...The American Journal of Tropical Medicine and Hygiene | In Vitro Activity of Artemisinin in Combination with Clotrimazole or...

HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin ... Antimicrob Agents Chemother 48 : 4097-4102.. * Berenbaum MC, 1978. A method for testing synergy with any number of agents. J ... Antimicrob Agents Chemother 41 : 2345-2351.. * Hatabu T, Takada T, Taguchi N, Suzuki M, Sato K, Kano S, 2005. Potent ... Antimicrob Agents Chemother 46 : 1510-1515.. * Sannella R, Messori L, Casini A, Vincieri FF, Bilia AR, Majori G, Severini C, ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.2008.78.721

Traditional Herbal Management of Sickle Cell Anemia: Lessons from NigeriaTraditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria

K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit (Carica papaya)," Transactions of the Royal ... G. I. Ekeke and F. O. Shode, "Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract," Planta Medica ... J. A. Walder, R. H. Zaugg, R. S. Iwaoka, W. G. Watkin, and I. M. Klotz, "Alternative aspirins as antisickling agents: acetyl-3, ... K. Gamaniel, S. Amos, P. Akah et al., "Pharmacological profile of NIPRD 94/002/1-0: a novel herbal antisickling agent," Journal ...
more infohttps://www.hindawi.com/journals/anemia/2012/607436/ref/

Sickle Cell Disease | Portsmouth Regional HospitalSickle Cell Disease | Portsmouth Regional Hospital

Kark JA, Tarassoff PG, Bongiovanni R. Pyridoxal phosphate as an antisickling agent in vitro. J Clin Invest. 1983;71:1224-1229. ...
more infohttps://portsmouthhospital.com/hl/?/38400/Sickle-Cell-Disease&com.dotmarketing.htmlpage.language=1

Sickle Cell Disease | Memorial HealthSickle Cell Disease | Memorial Health

Kark JA, Tarassoff PG, Bongiovanni R. Pyridoxal phosphate as an antisickling agent in vitro. J Clin Invest. 1983;71:1224-1229. ...
more infohttps://memorialhealth.com/hl/?/38400/sickle-cell-disease

vitamin B6<...vitamin B6<...

Kark JA, Tarassoff PG, Bongiovanni R. Pyridoxal phosphate as an antisickling agent in vitro. J Clin Invest 1983;71:1224-9. ... In test tube studies, vitamin B6 has been shown to have anti-sickling effects on the red blood cells of people with sickle cell ... 1 star] Vitamin B6 has been shown to have anti-sickling effects on the red blood cells. It can also correct vitamin B6 ...
more infohttps://www.evitamins.com/br/encyclopedia/assets/nutritional-supplement/vitamin-b6/~default

US4584130A - Intramolecularly cross-linked hemoglobin and method of preparation 
        - Google PatentsUS4584130A - Intramolecularly cross-linked hemoglobin and method of preparation - Google Patents

Physiological and x-ray studies of potential antisickling agents. HINK et al. 1957. Preparation and properties of a heat- ... w/v NaCl and/or reducing agents like ascorbic acid (e.g., 3 mg/ml) together with a chelating agent such as EDTA (e.g., 0.01-0.1 ... Hemoglobins as drug delivery agents US5767089A (en) * 1993-08-16. 1998-06-16. Hsia; Jen-Chang. Compositions and methods ... Hemoglobins as drug delivery agents US6669965B2 (en) 1992-02-07. 2003-12-30. Vasogen Ireland Limited. Method of treating ...
more infohttps://patents.google.com/patent/US4584130

Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid | SpringerLinkCombinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid | SpringerLink

Abraham, D.J., Gazze, D.M., Kennedy, P.E. and Makotoff, M.,Design, synthesis, and testing of potential antisickling agents. 5. ... Howe, R. and Smith, L.H.,Alkanolamine derivatives - beta-adrenergic blocking agents, U.S. Patent 3,712,927, 1973. ...
more infohttps://link.springer.com/article/10.1007%2FBF01721326
  • Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. (nih.gov)
  • Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (nih.gov)
  • Methanolic extracts of these three species and pure rosmarinic acid showed significant antisickling activities with minimal concentration of normalization values of 0.18 ± 0.03, 0.23 ± 0.04, 0.26 ± 0.04 and 0.31 ± 0.05 mg/mL for rosmarinic acid, O. basilicum L., O. gratissimum L. and O. canum Sims methanolic extracts respectively. (scirp.org)
  • Design, synthesis, and testing of potential antisickling agents. (springer.com)
  • The antisickling activity order is the same as that of the rosmarinic acid content, indicating that this polyphenolic acid would be among the main active molecules in these extracts. (scirp.org)
  • Antileishmanial activity of amphotericin and other antifungal agents entrapped in liposomes. (ajtmh.org)