AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Antisickling AgentsHemoglobin, SickleErythrocytes, AbnormalBenzaldehydesAnemia, Sickle CellAzepinesOxyhemoglobinsErythrocyte MembraneOxygenErythrocytesSolubilityDrug RepositioningHydroxyureaSickle Cell TraitCross-Over StudiesDouble-Blind MethodCystic FibrosisPseudomonas InfectionsPseudomonas aeruginosaDietary ProteinsStavudineNelfinavirDidanosineTreatment OutcomeHIV InfectionsAnti-HIV AgentsNasal DecongestantsAntifoaming AgentsFlavoring AgentsDictionaries, ChemicalNamesDentifricesNational Library of Medicine (U.S.)NephrologyHypericumCellular PhonePhalarisPoaceaeSongbirdsPhloroglucinolFetal HemoglobinAnemiaGemfibrozilbeta-ThalassemiaHypolipidemic AgentsValeratesAnionsThalassemia
Antisickling Agents
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
Hemoglobin, Sickle
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Erythrocytes, Abnormal
Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.
Benzaldehydes
Anemia, Sickle Cell
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Azepines
Seven membered heterocyclic rings containing a NITROGEN atom.
Oxyhemoglobins
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
Erythrocyte Membrane
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Oxygen
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Erythrocytes
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Solubility
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Drug Repositioning
The deliberate and methodical practice of finding new applications for existing drugs.
Hydroxyurea
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Sickle Cell Trait
The condition of being heterozygous for hemoglobin S.
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS.
Pseudomonas aeruginosa
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Dietary Proteins
Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.
Stavudine
A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Nelfinavir
A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Didanosine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Anti-HIV Agents
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Nasal Decongestants
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Antifoaming Agents
Agents used to prevent the formation of foam or to treat flatulence or bloat.
Flavoring Agents
Substances added to foods and medicine to improve the quality of taste.
Dictionaries, Chemical
Names
Personal names, given or surname, as cultural characteristics, as ethnological or religious patterns, as indications of the geographic distribution of families and inbreeding, etc. Analysis of isonymy, the quality of having the same or similar names, is useful in the study of population genetics. NAMES is used also for the history of names or name changes of corporate bodies, such as medical societies, universities, hospitals, government agencies, etc.
Dentifrices
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
National Library of Medicine (U.S.)
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Nephrology
A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney.
Hypericum
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Phalaris
A plant genus of the family POACEAE.
Poaceae
A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.
Songbirds
PASSERIFORMES of the suborder, Oscines, in which the flexor tendons of the toes are separate, and the lower syrinx has 4 to 9 pairs of tensor muscles inserted at both ends of the tracheal half rings. They include many commonly recognized birds such as CROWS; FINCHES; robins; SPARROWS; and SWALLOWS.
Phloroglucinol
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
Fetal Hemoglobin
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Gemfibrozil
A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
beta-Thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Hypolipidemic Agents
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
Valerates
Anions
Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
Thalassemia
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. (1/147)

1. The actions of some inhibitors of the Ca2+-activated K+ permeability in mammalian red cells have been compared. 2. Block of the permeability was assessed from the reduction in the net loss of K+ that followed the application of the Ca2+ ionophore A23187 (2 microM) to rabbit red cells suspended at a haematocrit of 1% in a low potassium solution ([K]0 0.12-0.17 mM) at 37 degrees C. Net movement of K+ was measured using a K+-sensitive electrode placed in the suspension. 3. The concentrations (microM +/- s.d.) of the compounds tested causing 50% inhibition of K+ loss were: quinine, 37 +/- 3; cetiedil, 26 +/- 1; the cetiedil congeners UCL 1269, UCL 1274 and UCL 1495, approximately 150, 8.2 +/- 0.1, 0.92 +/- 0.03 respectively; clotrimazole, 1.2 +/- 0.1; nitrendipine, 3.6 +/- 0.5 and charybdotoxin, 0.015 +/- 0.002. 4. The characteristics of the block suggested that compounds could be placed in two groups. For one set (quinine, cetiedil, and the UCL congeners), the concentration-inhibition curves were steeper (Hill coefficient, nH, > or = 2.7) than for the other (clotrimazole, nitrendipine, charybdotoxin) for which nH approximately 1. 5. Compounds in the first set alone became less active on raising the concentration of K+ in the external solution to 5.4 mM. 6. The rate of K+ loss induced by A23187 slowed in the presence of high concentrations of cetiedil and its analogues, suggesting a use-dependent component to the inhibitory action. This was not seen with clotrimazole. 7. The blocking action of the cetiedil analogue UCL 1274 could not be overcome by an increase in external Ca2+ and its potency was unaltered when K+ loss was induced by the application of Pb2+ (10 microM) rather than by A23187. 8. These results, taken with the findings of others, suggest that agents that block the red cell Ca2+-activated K+ permeability can be placed in two groups with different mechanisms of action. The differences can be explained by supposing that clotrimazole and charybdotoxin act at the outer face of the channel whereas cetiedil and its congeners may block within it, either at or near the K+ binding site that determines the flow of K+.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/147)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/147)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Persistent respiratory effects in survivors of the Bhopal disaster. (4/147)

OBJECTIVE: To examine the role of exposure to the 1984 Bhopal gas leak in the development of persistent obstructive airways disease. DESIGN: Cross sectional survey. SETTING: Bhopal, India. SUBJECTS: Random sample of 454 adults stratified by distance of residence from the Union Carbide plant. MAIN OUTCOME MEASURES: Self reported respiratory symptoms; indices of lung function measured by simple spirometry and adjusted for age, sex, and height according to Indian derived regression equations. RESULTS: Respiratory symptoms were significantly more common and lung function (percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), and FEV1/FEV ratio) was reduced among those reporting exposure to the gas leak. The frequency of symptoms fell as exposure decreased (as estimated by distance lived from the plant), and lung function measurements displayed similar trends. These findings were not wholly accounted for by confounding by smoking or literacy, a measure of socioeconomic status. Lung function measurements were consistently lower in those reporting symptoms. CONCLUSION: Our results suggest that persistent small airways obstruction among survivors of the 1984 disaster may be attributed to gas exposure.  (+info)

The reaction of deoxy-sickle cell hemoglobin with hydroxyurea. (5/147)

In addition to its capacity to increase fetal hemoglobin levels, other mechanisms are implicated in hydroxyurea's ability to provide beneficial effects to patients with sickle cell disease. We hypothesize that the reaction of hemoglobin with hydroxyurea may play a role. It is shown that hydroxyurea reacts with deoxy-sickle cell hemoglobin (Hb) to form methemoglobin (metHb) and nitrosyl hemoglobin (HbNO). The products of the reaction as well as the kinetics are followed by absorption spectroscopy and electron paramagnetic resonance (EPR) spectroscopy. Analysis of the kinetics shows that the reaction can be approximated by a pseudo-first order rate constant of 3.7x10(-4) (1/(s.M)) for the disappearance of deoxy-sickle cell hemoglobin. Further analysis shows that HbNO is formed at an observed average rate of 5.25x10(-5) (1/s), three to four times slower than the rate of formation of metHb. EPR spectroscopy is used to show that the formation of HbNO involves the specific transfer of NO from the NHOH group of hydroxyurea. The potential importance of this reaction is discussed in the context of metHb and HbNO being able to increase the delay time for sickle cell hemoglobin polymerization and HbNO's vasodilating capabilities through conversion to S-nitrosohemoglobin.  (+info)

Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. (6/147)

Previous studies have determined the short-term toxicity profile, laboratory changes, and clinical efficacy associated with hydroxyurea (HU) therapy in adults with sickle cell anemia. The safety and efficacy of this agent in pediatric patients with sickle cell anemia has not been determined. Children with sickle cell anemia, age 5 to 15 years, were eligible for this multicenter Phase I/II trial. HU was started at 15 mg/kg/d and escalated to 30 mg/kg/d unless the patient experienced laboratory toxicity. Patients were monitored by 2-week visits to assess compliance, toxicity, clinical adverse events, growth parameters, and laboratory efficacy associated with HU treatment. Eighty-four children were enrolled between December 1994 and March 1996. Sixty-eight children reached maximum tolerated dose (MTD) and 52 were treated at MTD for 1 year. Significant hematologic changes included increases in hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, and fetal hemoglobin parameters, and decreases in white blood cell, neutrophil, platelet, and reticulocyte counts. Laboratory toxicities typically were mild, transient, and were reversible upon temporary discontinuation of HU. No life-threatening clinical adverse events occurred and no child experienced growth failure. This Phase I/II trial shows that HU therapy is safe for children with sickle cell anemia when treatment was directed by a pediatric hematologist. HU in children induces similar laboratory changes as in adults. Phase III trials to determine if HU can prevent chronic organ damage in children with sickle cell anemia are warranted.  (+info)

Acetylation of human hemoglobin by methyl acetylphosphate. Evidence of broad regio-selectivity revealed by NMR studies. (7/147)

The development of chemical modification agents that reduce the tendency of sickle hemoglobin (HbS) to aggregate represents an important chemotherapeutic goal. Methyl acetylphosphate (MAP) has been reported to bind to the 2,3-diphosphoglycerate (2,3-DPG) binding site of hemoglobin, where it selectively acetylates residues, resulting in increased solubility of HbS. We have prepared [1-(13)C]MAP and evaluated the adduct formation with hemoglobin using (1)H-(13)C HMQC and HSQC NMR studies. These spectra of the acetylated hemoglobin adducts showed 10-11 well resolved adduct peaks, indicating that the acetylation was not highly residue specific. The chemical shift pattern observed is in general similar to that obtained recently using [1'-(13)C]aspirin as the acetylating agent (Xu, A. S. L., Macdonald, J. M., Labotka, R. J., and London, R. E. (1999) Biochim. Biophys. Acta 1432, 333-349). Blocking the 2, 3-DPG binding site with inositol hexaphosphate (IHP) resulted in a selective reduction in intensity of adduct resonances, presumably corresponding to residues located in the 2,3-DPG binding cleft. The pattern of residue protection appeared to be identical to that observed in our previous study using IHP and labeled aspirin. Pre-acetylation of hemoglobin using unlabeled MAP, followed by acetylation with [1'-(13)C]aspirin indicated a general protective effect, with the greatest reduction of intensity for resonances corresponding to acetylated residues in the 2,3-DPG binding site. These studies indicated that both MAP and aspirin exhibit similar, although not identical, acetylation profiles and target primarily the betaLys-82 residue in the 2,3-DPG binding site, as well as sites such as betaLys-59 and alphaLys-90, which are not located in the beta-cleft of hemoglobin.  (+info)

Preliminary report of a toxicity study of hydroxyurea in sickle cell disease. French Study Group on Sickle Cell Disease. (8/147)

AIM: To evaluate the tolerance of hydroxyurea in children affected with sickle cell disease. DESIGN: Questionnaire study of French physicians likely to treat patients with sickle cell disease. Data were collected on 101 children with sickle cell disease, treated for a median of 22 months, 36 of whom were treated for more than three years. 13 children were younger than 5 years of age at inclusion. RESULTS: Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus. Acute lymphoblastic leukaemia occurred in a girl treated for 1.5 months with hydroxyurea, this short interval arguing against a causative association. One 17 year old boy had paraparesis after 8 years of treatment. CONCLUSIONS: No major short or medium term toxicity was related to hydroxyurea in this cohort of 101 children. However, the number of children treated for more than 3 years is too few to make firm conclusions on the long term tolerance of this drug.  (+info)

Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization -...Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization -...
Abstract: The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries (LMICs).. This paper outlines conceptual frameworks of three primary stroke prevention strategies: (a) the polypill strategy; (b) a population-wide strategy; and (c) a motivational population-wide strategy.. (a) A polypill containing generic low-dose ingredients of blood pressure and lipid-lowering medications (e.g. candesartan 16 mg, amlodipine 2.5 mg, and rosuvastatin 10 mg) seems a safe and cost-effective approach for primary prevention of stroke and dementia.. (b) A population-wide strategy reducing cardiovascular risk factors in the whole population, regardless of the level of risk is the most effective primary prevention strategy. A motivational population-wide strategy for the modification of health behaviors (e.g. smoking, ...
http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=LDEAvdc_100091508556.0x000001&indx=6&recIds=LDEAvdc_100091508556.0x000001&recIdxs=5&elementId=5&renderMode=poppedOut&displayMode=full&frbrVersion=&gathStatTab=true&dscnt=0&vl
Clinical research in primary stroke prevention: Needs, opportunities, and challenges<...Clinical research in primary stroke prevention: Needs, opportunities, and challenges<...
TY - JOUR. T1 - Clinical research in primary stroke prevention. T2 - Needs, opportunities, and challenges. AU - Radziszewska, Barbara. AU - Hart, Robert G.. AU - Wolf, Philip A.. AU - DAgostino, Ralph B.. AU - Cutler, Jeffrey A.. AU - Broderick, Joseph P.. AU - Coull, Bruce M.. AU - Cushman, Mary. AU - DAgostino, Ralph B.. AU - Easton, Donald J.. AU - Einhorn, Paula. AU - Goldstein, Larry B.. AU - Gorelick, Philip B.. AU - Haffner, Steven. AU - Howard, George. AU - Johnston, S. Claiborne. AU - Kernan, Walter. AU - Longstreth, Will. AU - Pandey, Dilip K.. AU - Polak, Joseph F.. AU - Sacco, Ralph L.. AU - Singer, Daniel E.. AU - Toole, James. AU - Warach, Steven J.. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Most (∼70%) of strokes are first-ever strokes, and hence to substantially reduce the neurological burden, primary prevention is crucial. Here, highlights of the National Institute of Neurological Disorders and Stroke workshop Stroke Risk Assessment and Future Stroke Primary Prevention Trials ...
https://utsouthwestern.pure.elsevier.com/en/publications/clinical-research-in-primary-stroke-prevention-needs-opportunitie
Hydroxycarbamide (hydroxyurea) 500mg Over The Counter | Hydroxycarbamide Online PharmacyHydroxycarbamide (hydroxyurea) 500mg Over The Counter | Hydroxycarbamide Online Pharmacy
Buy Hydroxycarbamide (hydroxyurea) 500mg online without prescription in USA, Canada, Australia, UK and Europe. Fast order delivery. Worldwide shipping. FDA approved RX online pharmacy.
http://www.hughesanderson.com/wordpress/wp-content/pharmacy/hydroxycarbamide.html
Lipid Lowering for Primary Stroke Prevention in Elderly?Lipid Lowering for Primary Stroke Prevention in Elderly?
The use of statins or fibrates was associated with a one third lower risk for stroke in older adults without previous vascular disease in a new observational study.
https://www.medscape.com/viewarticle/845007
Hugs. | The Red Ferret JournalHugs. | The Red Ferret Journal
The Hugs Shirt. The Ferret prefers his hugs bear style not virtual, but the F+R Hugs Shirt is bound to enthuse legions of eager young things anxious for a textile caress. Oh yes. [via the rather delicious We Make Money….]. F+R Hugs is a wearable system that allows to feel the physical closeness of a distant loved one, bringing the pleasant sensation of a hug to body and mind. Is designed to satisfy a desire shared by many people: communicate emotions to distant people we love in a tangible way. Functionallity and use of design: The F+R Hugs system works through a mobile phone network. F+R Hugs shirts receive the input of heart beat, touch and body temperature of the remote loved one, and output it, recreating (through actuators embedded in the shirt) the pulsation, physical pressure, and warmth of a real hug. ...
http://www.redferret.net/?p=5081
contented82 | The Contented Family | Page 2contented82 | The Contented Family | Page 2
Firstly, you need to make sure youre getting enough hugs. Experts range from recommending between 8 - 12 hugs daily.. Secondly, you need to make sure that your hugs count. A half-hearted attempt will not have the same results. Give into the hug, throw both arms around your hug partner and fully embrace them, the longer the physical connection the better. I like to practice 3 breath hugs, no matter how busy you are, you can stop for this time. I also prefer to count breaths as oppose to seconds as that keeps me more in tune with my own bodys rhythm.. Finally, be the hug. Dont think about what you are cooking for dinner, your to do list or a meeting at work. The best way to get the most out of your hug is to focus on how it feels. Be mindful of the weight of the other person and how their body feels as it connects with yours.. Be the hug.. The Contented Family Hugging Challenge. For one week I am going to monitor my hugs. I am interested to see if I already hug enough, I have never counted so I ...
http://www.thecontentedfamily.co.uk/author/contented82/page/2/
Hug Jez Alborough PDF 825007bf9 - AZ NewsHug Jez Alborough PDF 825007bf9 - AZ News
This Hug book is not really ordinary book, you have it then the world is in your hands. The benefit you get by reading this book is actually information inside this reserve incredible fresh, you will get information which is getting deeper an individual read a lot of information you will get. This kind of Hug without we recognize teach the one who looking at it become critical in imagining and analyzing. Dont be worry Hug can bring any time you are and not make your tote space or bookshelves grow to be full because you can have it inside your lovely laptop even cell phone. This Hug having great arrangement in word and layout, so you will not really feel uninterested in reading.. ...
http://aznews.site/hug-jez-alborough-pdf-825007bf9
Farmer Freitas Wife.....: They call me The Leech...Farmer Freitas Wife.....: They call me The Leech...
He also loves to hug and not let go. Hes a good hugger and thats where the Teddy part comes in...like a big ol teddy bear. He is the one who taught me that there are different kinds of hugs. The side hug...for people you dont really want to hug. The back slapping hug....which mocho guys usually do. The close friend and family hug...where your right arm goes over the other persons left shoulder and left arm goes under the other persons right arm. Thats the best hug for squeezing and not letting go. And the awkward hug, unless youre married and like to hug like this...(which I do)...woman hugs mans waist and man loosely wraps his arms around woman. That too is good for squeezing and not letting go ...
http://nate-becky.blogspot.com/2011/11/they-call-me-leech.html
Why we missed hugs | Newsy NewsWhy we missed hugs | Newsy News
Rose Gagnon could not hug her grandchildren for several months.. Not being able to see and touch her loved ones every day because of COVID-19s social distancing protocols was taking a toll on the mental health of the 85-year-old. Like many, she was feeling lonely and yearning for an emotional connection that had been hampered by the inability to embrace those most important to her.. Thats when Gagnons granddaughter Carly Marinaro devised an innovative solution in the form of a hug time device. Inside a frame made of PVC piping, Marinaro fashioned a see-through plastic barrier with two arm attachments, so that grandmother and granddaughter could share a hug while minimizing the risk of exposure to the coronavirus.. Like Gagnon, many Americans have missed the warmth of an embrace, the intimacy of a kiss or the calming feeling of holding someones hand. When the Centers for Disease Control and Prevention issued its advice to stay 6 feet apart from others back in March 2020, that suddenly made ...
https://www.newsy.site/2021/08/16/why-we-missed-hugs/
A hug can have such a positive impact: Ont. family working to bring Hug Glove to isolated CanadiansA hug can have such a positive impact: Ont. family working to bring Hug Glove to isolated Canadians
An Ontario family that created a Hug Glove so they could hug their grandma amid the COVID-19 pandemic have partnered with a Canadian manufacturer to bring the product to others in need of an embrace.
https://www.ctvnews.ca/health/coronavirus/a-hug-can-have-such-a-positive-impact-ont-family-working-to-bring-hug-glove-to-isolated-canadians-1.5419423?cache=yes%3FclipId%3D375756%3FautoPlay%3Dtrue%3FautoPlay%3Dtrue%3FclipId%3D373266
How Hugs are Proven to Help Your Health: Have You Been Hugged Today?How Hugs are Proven to Help Your Health: Have You Been Hugged Today?
Hugs are good for your heart, your blood pressure and your overall health -- just a few of the reasons to hug your loved ones today.
http://www.sixwise.com/newsletters/06/07/26/how_hugs_are_proven_to_help_your_health_have_you_been_hugged_today.htm
arm hug pillowarm hug pillow
arm hug pillow hasbeen chosen by the newly married couple to perform your house. arm hug pillow. Along with its style that is modern but nonetheless straightforward, this table been because of several advantages such as could be applied as a way of collecting together a childs learning, your family, a spot so forth and to place the kitchen equipment.
https://www.kiddys-shop.com/arm-hug-pillow-72666/
Free Hugs Campaign - Official Page (music by Sick Puppies.net ) - Dherbs VideosFree Hugs Campaign - Official Page (music by Sick Puppies.net ) - Dherbs Videos
Download the Free Hugs soundtrack here: Sick Puppies New Album Tri-Polar Available Now! http://www.itunes.com/sickpuppies Get your Free Hugs t-shirts here: http://www.bandmerch.com/freehugscampaign...
https://www.dherbs.com/dhtv/inspirational-videos/free-hugs-campaign-official-page-music-by-sick-puppies-net/
0 Comments0 Comments
Studies show we need 4 hugs a day for survival. We need 8 hugs a day for maintenance. We need 12 hugs a day for growth. And did you know that, on average, people spend one hour a month hugging? That doesnt sound like much, but when you consider that the average hug is under 10 seconds long… thats a lot of hugs ...
http://www.wonnampa.com/won-tips/weekly-won-tip6394976
Ticicalli Yahualli: 2012Ticicalli Yahualli: 2012
My partner kept suggesting I sleep poor thing he was tired but I kept saying I couldnt...until someone else suggested it of course. My sisters put me on my side and encouraged me to try to sleep between contractions. I did and a few minutes after I felt a thump in my vagina, I got up quick and ran to the foot of the bed. I felt the contractions hug my baby hug every piece of feet , legs...everything...it was both amazing and overwhelming. I was freaking out and started to panic I had never felt this before my womb hugging my semillas body...my womb guiding me telling me where the baby was what my baby was doing....wow! I kept yelling The babys coming! The babys coming! In that moment of panic Panquetzani said Its ok your body will know what to do. I closed my eyes and I felt the baby swim down and slipped into her fathers hands...then I guess she slipped out because I heard a cry and dad was panicking that he dropped the baby....lol thats the last time I trust him to catch a ...
http://ticicalli.blogspot.com/2012/
The Baby Was Dying, But Was Rescued By Her Twins Hug. It Changed Health Care Forever.The Baby Was Dying, But Was Rescued By Her Twins Hug. It Changed Health Care Forever.
The Baby Was Dying, But Was Rescued By Her Twins Hug. It Changed Health Care Forever.. Newsner give you the news that truly matters to you!
https://en.newsner.com/family/the-baby-was-dying-but-was-rescued-by-her-twins-hug-it-changed-health-care-forever/
Clinical research at HUGClinical research at HUG
Research activities are an integral part of HUGs mission and is done in close collaboration with the University of Geneva Faculty of Medicine.
https://www.hug-ge.ch/en/clinical-research-hug
Hugs can improve our relationships, according to science - especially after an argument | Business InsiderHugs can improve our relationships, according to science - especially after an argument | Business Insider
Sometimes all you need is a hug. Not only do they feel warm and cosy, but hugging is also good for our mentality. Research has shown how hugging releases oxytocin - the love hormone - which helps us bond with each other, and can also reduce blood pressure. The positive effects of hugging could even help you ward off a winter cold.
https://www.businessinsider.com.au/hugs-improve-relationships-after-arguments-study-says-2018-10
Do they really have to hug or kiss?Do they really have to hug or kiss?
This brings me to the point of this post which is something I really need us to pay attention to. I think its about time we start teaching our kids about consent and setting boundaries around themselves or their bodies. When our kids meet family, friends or even strangers for the first time, we usually instruct (for lack of a better word) them to hug or kiss strangers in a bid not to make them seem rude or unfriendly. This is very common, and not unconnected to our culture. Sometimes, we go a bit far by forcing them to do so, even when they are clearly not comfortable with it. ...
http://thebabyanalyst.blogspot.com/2016/12/do-they-really-have-to-hug-or-kiss.html
Free AP Human Geography Flashcards about HUG Chap 2Free AP Human Geography Flashcards about HUG Chap 2
Free flashcards to help memorize facts about HUG Chap 2. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
https://www.studystack.com/flashcard-2010265
Hugs for Everyone ))) | DailyStrengthHugs for Everyone ))) | DailyStrength
Hi everyone. I am feeling kinda weird, I cant seem to really focus on everything being posted so I wanted to give you all a hug and hope you are doing well and if.....
https://www.dailystrength.org/group/bipolar-disorder/discussion/hugs-for-every_37
Jump Clubb offer A Frozen Hug | Parasites & SycophantsJump Clubb offer A Frozen Hug | Parasites & Sycophants
Jump Clubb, an anonymous group from Beverly Hills, offer up A Frozen Hug. Their debut LP The Love Of No Dance is out October 6th.. audio ...
http://www.parasitesandsycophants.com/2009/09/23/jump-clubb-offer-a-frozen-hug/
Want to HUG a BUNNY?!?: Gainesville Rabbit Rescue Inc. Opportunity - VolunteerMatchWant to HUG a BUNNY?!?: Gainesville Rabbit Rescue Inc. Opportunity - VolunteerMatch
Gainesville Rabbit Rescue Inc. offers the opportunity to serve your community through Want to HUG a BUNNY?!?. This is an ongoing opportunity located in Gainesville, Florida.
https://www.volunteermatch.org/search/opp1329677.jsp
Hugs - Essay by BillygunnyHugs - Essay by Billygunny
Hug is defined by the Oxford dictionary as to clasp tightly in the arms, especially with affection; embrace. Yet, a simple vocabulary with a simple action
http://www.antiessays.com/free-essays/Hugs-94319.html
A Randomized, Open-label, Multicenter, Controlled, Parallel Arm, Phase III Study Assessing the Efficacy and Safety of AOP2014...A Randomized, Open-label, Multicenter, Controlled, Parallel Arm, Phase III Study Assessing the Efficacy and Safety of AOP2014...
This trial is investigating the efficacy and safety of peginterferon alfa-2b [AOP 2014, P 1101; AOP Orphan Pharmaceuticals AG] versus hydroxycarbamide
http://adisinsight.springer.com/trials/700227338?error=cookies_not_supported&code=12dd8e84-b8e5-4ed5-9fc3-f4e6b7b914e5
Sketchy Science: 2016Sketchy Science: 2016
A good way to evaluate the scientific merit of a conclusion is to think about how you would go about researching it under ideal conditions. If we want to test the hypothesis that dogs dont like hugs, there are simple ways to get closer to an answer than by looking at random pictures online. First, you would want the dogs in an environment that doesnt stress them out, preferably at home. That would allow us to rule out the surroundings as a source of stress and focus purely on the hugs. Second, you would want to control for the person doing the hugging. In this case, the findings are seeking to scold dog owners for forcing human affection onto dogs, so the dogs should only be hugged by people they know and trust. Finally, we would control the situation. Are the hugs happening out of the blue or is the dog relaxing with its owner on the couch after a long day of hiking? These are things that matter ...
http://www.sketchyscience.com/2016/
Items filtered by date: May 2013Items filtered by date: May 2013
Man, the kids are amazing. I expected to have some smart-alec kids here and there booing us or whatever, but they get right into it. Now I totally understand, because I would have loved a band to come to our school, and its an excuse for them to get out of class. We also get to do a workshop with them afterwards, and they can ask us questions about the industry, and watch us set up and soundcheck, so its a real learning experience. We cant play Im Not A Whore, and we find alternatives for a couple of swear words, but for the most part its really relaxed. The obvious rules are no swearing and always being courteous, although were not allowed to hug the students front-on. We do signings after the show and a lot of the students want a hug, but were only allowed to do side hugs. We thought it was funny, but rules are rules ...
http://scenemagazine.com.au/date/2013/5/Page-2
Lucys Lounge: November 2009Lucys Lounge: November 2009
I like hugs to some extent, just so theyre not over the top. Since Mama works from home, she often hugs and kisses me during the day while Im taking my naps. In the evenings, I wait for her to come in the room to play with me. However, I dont always play. Sometimes I just watch the toy and then walk out on both her and the toy to eat some foodies in the kitchen. Other times, after playing, I climb in her lap for a few minutes while she sits on the floor with me. Whatever my mood may be, I wait every night for her to come in and give me some kind of attention. If she works really late, Ill go out to her and let her know Im waiting. Back to the original subject of hugs: do you like them or are you more reserved or do you prefer other means of affection? ...
http://gooeylounge.blogspot.ch/2009/11/
Wheres Katie?: Hugs are For the ComforterWheres Katie?: Hugs are For the Comforter
Surprisingly, part of my discovery in examining how I feel this time around, is that I dont feel any additional pain because we had to also inform family and friends of the miscarriage. This has been my excuse for not informing others during the trial, as I assumed that family would get overly excited at an announcement, and it would only add to my pain to feel responsible for communicating the loss with others. Instead, Ive appreciated everyones texts and prayers. It certainly helped that everyone was very considerate when I said I didnt want to talk those first few days after the second ultrasound. Over all I feel like communicating during this trial may have helped me to feel closer and more grateful for those relationships ...
http://katie-newsletter.blogspot.com/2017/03/hugs-are-for-comforter.html
Are more men or women seeking out Cuddle Therapy? - Holistic HugsAre more men or women seeking out Cuddle Therapy? - Holistic Hugs
A question that often pops up when Im chatting to people about cuddle therapy is Are there more male or female clients? This is purely my experience and may be different for other professional cuddlers around the world.On average I find 9 out of 10 of the people contacting me about cuddle therapy are men…
https://holistichugs.co.uk/2020/08/21/are-more-men-or-women-seeking-out-cuddle-therapy/
Newbie needs a hug | DailyStrengthNewbie needs a hug | DailyStrength
I was late making moms breakfast and she smarted off to me that she has never been fed this late and thought I wasnt going to feed her at all! She is totally...
https://www.dailystrength.org/group/caring-for-aging-parents/discussion/newbie-needs-a-hug
I missed you so much: Grandma hugs grandson for the first time after getting COVID-19...I missed you so much: Grandma hugs grandson for the first time after getting COVID-19...
What a sweet moment! A grandmother was filmed hugging her grandson for the first time in months after getting the COVID-19 vaccine.
https://www.fox9.com/news/i-missed-you-so-much-grandma-hugs-grandson-for-the-first-time-after-getting-covid-19-vaccine
Smoke Signals - Cavetown (cover) by creeper hugs @ Ultimate-Guitar.ComSmoke Signals - Cavetown (cover) by creeper hugs @ Ultimate-Guitar.Com
Number one: Im sick thats why my voice sounds weird. Number two: I was holding my iPad with my knees so thats why the screen is shaking
https://www.ultimate-guitar.com/shot/creeper_hugs/490134218
LOVME » AwarenessLOVME » Awareness
Hug a GI Day is for all the men and women who proudly serve for your country. You can give a big hug to all GIs you see today to thank them. If you do not know any GIs show ...
http://lovme.org/awareness/
Hug Me Im Vaccinated - SkepchickHug Me Im Vaccinated - Skepchick
As you have probably already heard, Women Thinking, inc has spent the last couple years working on a project funded by the JREF to survey parents who are fence-sitters on the issue of vaccinating their children. The project is a kind of market survey to learn which arguments these parents find most persuasive in convincing them that vaccinating their children…. Read More » ...
https://skepchick.org/tag/hug-me-im-vaccinated/
Luna Shades Mom Chrissy Teigen, Queen of Shade, at Disney - SheKnowsLuna Shades Mom Chrissy Teigen, Queen of Shade, at Disney - SheKnows
Chrissy Teigen is cracking up that her daughter, Luna, refuses to hug her - but will happily hug a stranger dressed as Minnie Mouse.
https://www.sheknows.com/parenting/articles/1138634/chrissy-teigen-luna-disney/
Fighting the System | Little Ladybug HugsFighting the System | Little Ladybug Hugs
When we began looking at custom equipment for Ladybug a couple of years ago, I never imagined having to search for funding options due to the exorbitant Canadian prices, let alone fighting to get these much-needed items. After pushing for over 1 1/2 years Ladybug finally got her custom standing frame last week. One would think…
https://littleladybughugs.com/2013/07/26/fighting-the-system/
Gone Shopping - Hug the UndersquidGone Shopping - Hug the Undersquid
Not sure where Im going with this. When I went to Pixton to try to create something to distract myself, I just kept slapping one thing after another, not sure of what Id come up with. Theres a story there, but Ill probably get back to it much later. Or never. Tuesday, June 6, 2017…
https://undersquid.blog/2017/06/04/gone-shopping/
The bypassThe bypass
Mike had stayed with Isaiah overnight, so I headed down to the hospital early in the morning. When I went to his inpatient room it was empty. I hurried down to the second floor to catch up with them and luckily got there just before they entered the pre-surgical area. For whatever reason, Isaiah was being distant from me and wouldnt give me a hug. I was heartbroken. It was as if I needed him to support me, instead of me supporting him. I knew he was tired and did not grasp the seriousness of the situation, but it was still hard for me to accept that he would not provide me with the affection I so desperately needed at that moment. The anesthesiologist came to examine Isaiah and talk to us. Before I knew it, they were ready to take him away. For all of Isaiahs other procedures I had always been allowed to carry him into the procedure room and stay with him until he drifted off peacefully, like the perfect patient, under the spell of the magical bubblegum-scented anesthetic. This time was ...
http://isaiahskdjourney.blogspot.ca/2013/11/the-bypass.html
Siobhan - The Daily KittenSiobhan - The Daily Kitten
Oh no….Emma, my heart goes out to you and Ruggles. Hug each other tightly and please know you did the right thing for Rotley.. ...
http://dailykitten.com/members/siobhan/
Zeteos: February 2009Zeteos: February 2009
In keeping with CreativeWorks tradition of quality and speed when it comes to any project, CW designed and created the 3-D Pozles Universe, from scratch, in a phenomenal 4 days! In less than 100 hours from contact, or in less time than it would take to drive across the United States, CreativeWorks built an entire, imaginative 3-D Universe for Big Hug Productions ...
http://zeteos.blogspot.com/2009/02/
Fail Your Way to SuccessFail Your Way to Success
Learn how to fail... like it, take joy in it, welcome failure with wide open arms, hug it, kiss it, make it your best friend. Then fail your way to success
https://www.flexyourbrain.com/fail-way-success/
Why Im joining the March Against Monsanto - The Risk-MongerWhy Im joining the March Against Monsanto - The Risk-Monger
I am joining the March Against Monsanto to support those who feel afraid, vulnerable and angry. Over-stressed, they need a hug - so that is what Ill be doing!
https://risk-monger.com/2016/05/20/why-im-joining-the-march-against-monsanto/?like_comment=99&_wpnonce=dad35599db
CSS : image has space around it in DIVCSS : image has space around it in DIV
I am trying to get the div to hug the image, it seems that the vertical side of the DIV do, but the horizontial edges dont. I have tried different things. and I cant seem to get rid of the white space. My only other option is to use position and set everything static on the page, I really dont want to do that .. I just want the little white spaces gone. Anyone have any suggestions? Here is a link to my page cconway.com/v5 Thanx Chuck
http://www.sitepoint.com/forums/showthread.php?77642-CSS-image-has-space-around-it-in-DIV
Pucker Up: The Science of KissingPucker Up: The Science of Kissing
Thursday night I was finally able to land a date with a very attractive woman I met a few weeks before. All went well -dinner, club, dancing, light nightcaps- then came the pivotal moment of every first date. Go for the kiss or hug?
http://thesop.org/story/health/2006/07/28/pucker-up-the-science-of-kissing.php
Is there a sensory issue?Is there a sensory issue?
My child has fine motor issues, cannot ride a bike with training wheels at age 5, Is constantly touching things. Hugs constantly and impulsively, does
https://www.sensory-processing-disorder.com/is-there-a-sensory-issue.html
Part 6 - TTC #2 - The Family | Page 38 | Bub HubPart 6 - TTC #2 - The Family | Page 38 | Bub Hub
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 38
https://www.bubhub.com.au/community/forums/showthread.php?400131-Part-6-TTC-2-The-Family/page38
Part 6 - TTC #2 - The Family | Page 26 | Bub HubPart 6 - TTC #2 - The Family | Page 26 | Bub Hub
hi girls :wave: Im back and have missed you all! DD BIG :hugs: to you, poor wee poppet - I was gutted it didnt work for you this time - stupid universe. We will be rooting for ya in a month or so time when you get two wee embies on - page 26
https://www.bubhub.com.au/community/forums/showthread.php?400131-Part-6-TTC-2-The-Family/page26
Altmetric - Hydroxyurea (hydroxycarbamide) for sickle cell diseaseAltmetric - Hydroxyurea (hydroxycarbamide) for sickle cell disease
Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical problems of SCD, in particular that of pain, by raising fetal haemoglobin. This is an update of a previously published Cochrane Review. To assess the effects of hydroxyurea therapy in people with SCD (all genotypes), of any age, regardless of setting. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Register, comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also searched online trial registries.Date of the most recent search: 16 January 2017. Randomised and quasi-randomised controlled trials, of one month or longer, comparing hydroxyurea with placebo, standard therapy or other interventions ...
https://cochrane.altmetric.com/details/19233734
Treating sickle cell disease with hydroxyurea therapy - a game changer - Ghana Business NewsTreating sickle cell disease with hydroxyurea therapy - a game changer - Ghana Business News
Sickle Cell Disease (SCD), is the most common inherited serious blood disorders. It is characterised by chronic anaemia, recurrent attacks of severe pain and complications leading to the blockage of blood flow. The mortality rate tend to be high.. Approximately, 80 per cent of babies born with the disease, globally, are in Sub-Saharan Africa. Between 80 and 90 per cent of these children die before their fifth birthday.. This group of blood disorders is reported to account for five per cent of under-five mortality in the Sub-Saharan Africa and up to 16 per cent in West Africa (WHO Report, 2006).. More than 400,000 babies are born with the sickle cell disease across the world, every year, while in Ghana, 15,000 out of 959,000 newborns, are estimated to have the disease - typically inherited from a persons parents.. The cost of treatment is high in the country and throughout the African Continent. Added to this, is the limited medical services.. A serious gap in the management of the disease in ...
https://www.ghanabusinessnews.com/2019/12/10/treating-sickle-cell-disease-with-hydroxyurea-therapy-a-game-changer/
Quiz on Sickle Cell AnemiaQuiz on Sickle Cell Anemia
Sickle cell anemia is a genetic disorder that affects blood and necessitates frequent blood transfusions in certain cases. Test your knowledge on sickle cell anemia by taking this quiz.
http://www.medindia.net/medical-quiz/quiz-on-sickle-cell-anemia.asp
In vitro Antisickling properties, Free radicals quenching potential, protective properties against oxidative mediated ions...In vitro Antisickling properties, Free radicals quenching potential, protective properties against oxidative mediated ions...
Background: Sickle cell anaemia induces an abnormal haemoglobin (Hb S) synthesis. Hb S undergoes polymerization and causes the red blood cell (RBC) sickling with the production of reactive oxygen species (ROS). The present work aims to determine the antioxidant and anti-sickling activities of the combination of Theobroma cacao (T. cacao) extracts from different regions in Cameroon. Methods: The extract combinations (Santchou and Obala (CSOH), Bertoua and Mbalmayo (CMBH)) was prepared using water/ethanol (30v/70v; pH=3). Ferric Reducing Antioxidant Power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH°) and 2,2-azino-bis-[3-ethylbenzo-thiazolone-6-sulfonic acid] (ABTS°) scavenging properties of extracts were determined for the antioxidant capacity. The liver homogenate protective activity of extracts was estimated by measuring Superoxide dismutase (SOD), glutathione peroxidase (GPX), Malondialdehyde (MDA) and reduced glutathione (GSH). Osmotic fragility reduction and anti-sickling properties of the
http://herbmed.skums.ac.ir/article_35732.html
Library System/Howard UniversityLibrary System/Howard University
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
http://www.howard.edu/apps/keyword/huauthors.cfm?bysubject=Display%20Publications&yearrange2=0&bylastletter=&letteroflastname=&yearrange1=0&format=&oneyear=2012&department=Medicine&yeartype=OneYear&Page=25
Library System/Howard UniversityLibrary System/Howard University
Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled baby hug clinical trial for infants with sickle cell anemia. Pediatric Blood & Cancer, Vol.59, No.4 (2012): 668-674. Ofelia Alvarez, Scott T. Miller, Winfred C. Wang, Zhaoyu Luo, M. Beth McCarville, George J. Schwartz, Bruce Thompson, Thomas Howard, Rathi V. Iyer, Sohail R. Rana, Zora R. Rogers, Sharada A. Sarnaik, Courtney D. Thornburg, Russell E. Ware, and the BABY HUG Investigators.. ...
http://www.howard.edu/apps/keyword/huauthors.cfm?yearrange2=0&letteroflastname=&oneyear=2012&yeartype=OneYear&bysubject=Display%20Publications&yearrange1=0&format=&bylastletter=&department=Medicine&Page=25
Patente USRE42758 - Expandable curvilinear strut arrangement for deployment with a catheter to ... - Google PatentesPatente USRE42758 - Expandable curvilinear strut arrangement for deployment with a catheter to ... - Google Patentes
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
http://www.google.es/patents/USRE42758
Brevet USRE42758 - Expandable curvilinear strut arrangement for deployment with a catheter to ... - Google BrevetsBrevet USRE42758 - Expandable curvilinear strut arrangement for deployment with a catheter to ... - Google Brevets
The vasoocclusive apparatus can be used in a method of interventional therapy and vascular surgery by inserting the apparatus into a portion of a vasculature, for treatment of a body vessel such as an aneurysm in conjunction with a secondary vasoocclusive device to be placed within the vessel. The vasoocclusiveVasooclusive apparatus includes a plurality of strut members connected together at a central hub that extend from a collapsed position to an expanded configuration to cross the neck of the aneurysm, dividing the neck into smaller openings, allowing the deployment of the secondary vasoocclusive device within the aneurysm but preventing migration of the secondary vasoocclusive device from the aneurysm. The strut members can be made from a twisted cable of strands of a superelastic material, such as a shape memory nickel titanium alloy, with at least one radiopaque strand. A shape memory collar is provided for detachably mounting the vasoocclusive apparatus to a pusher member and for detaching the
http://www.google.fr/patents/USRE42758
Dr. Kim Smith-Whitley on Sickle Cell Anemia | Black America WebDr. Kim Smith-Whitley on Sickle Cell Anemia | Black America Web
Got a question about sickle cell anemia? Text it to 646464 (OHOHOH). --- There is good news on the horizon in sickle cell research. Researchers at The Childrens Hospital of Philadelphia (CHOP) are exploring a number of ways to stop the disease in its tracks and develop treatment option...
https://blackamericaweb.com/2012/12/11/dr-kim-smith-whitley-on-sickle-cell-anemia/
Sickle Cell Anemia 3 essay topic exampleSickle Cell Anemia 3 essay topic example
Free essay examples, how to write essay on Sickle Cell Anemia 3 example essay, research paper, custom writing. Write my essay on sickle cell blood.
http://essaypride.com/essays.php?free_essay=6854445&title=Sickle-Cell-Anemia-3
Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. - PubMed -...Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/18318767?dopt=Abstract
Preventing ischemic stroke: Current approaches to primary and secondary prevention<...Preventing ischemic stroke: Current approaches to primary and secondary prevention<...
TY - JOUR. T1 - Preventing ischemic stroke. T2 - Current approaches to primary and secondary prevention. AU - Ingall, Timothy J.. PY - 2000/5/15. Y1 - 2000/5/15. N2 - Preventing stroke is the most important strategy for reducing the cost of this disease. Management of modifiable risk factors, especially hypertension and cigarette smoking, has the greatest impact on prevention of first stroke. Other primary prevention strategies include: Oral anticoagulation with warfarin for selected high-risk patients with nonvalvular atrial fibrillation; Carotid endarterectomy for selected patients with carotid artery stenosis greater than 60%; Regular physical exercise; Treatment with statin medications for patients who have coronary artery disease with or without hyperlipidemia; Routine use of antiplatelet medication has no proven role in primary stroke prevention, although aspirin is often prescribed for patients with vascular risk factors who have not yet had symptoms of either stroke or ischemic heart ...
https://mayoclinic.pure.elsevier.com/en/publications/preventing-ischemic-stroke-current-approaches-to-primary-and-seco
Clinical Trial Seeking Vaso-Occlusive Sickle Cell Patients to Test RivipanselClinical Trial Seeking Vaso-Occlusive Sickle Cell Patients to Test Rivipansel
Find out more about enrolling in GlycoMimetics Phase 3 trial for rivipansel for the treatment of vaso-occlusive crisis in sickle cell disease patients.
https://sicklecellanemianews.com/2017/05/11/phase-3-trial-recruiting-to-test-rivipansel-for-vaso-occlusive-crisis-in-sickle-cell-disease/
Tizanidine a controlled substance dilantin nutrition interactions codeine en paracetamol tamiflu dose in swine fluTizanidine a controlled substance dilantin nutrition interactions codeine en paracetamol tamiflu dose in swine flu
Gabapentin ekg hydroxyurea therapy for diverse pediatric populations with sickle cell disease duphaston luteina razem effexor rxlist
http://vettv.eu/tizanidine-a-controlled-substance-dilantin-nutrition-interactions-codeine-en-paracetamol-tamiflu-dose-in-swine-flu
Annabelles Hugs - Not Just DollsAnnabelles Hugs - Not Just Dolls
If her big brown eyes dont melt your heart, feeling her arms around you certainly will! Meet Annabelles Hugs, our FIRST hugging monkey doll exclusively from The Ashton-Drake Galleries! This poseable, lifelike baby monkey doll is beautifully created by award-winning artist Ina Volprich and can be posed to give you the best little hugs! The monkey doll is handcrafted of our signature RealTouch® vinyl, with a cuddly cloth body that make her irresistibly huggable.. This darling doll is hand-painted to look So Truly Real® and sized at 22 inches long to feel that way, too! Annabelles Hugs Monkey Doll arrives in a pink polka-dot outfit to add to her sweetness.. Measures 22″ (55.9 cm) L. ©2014 The Ashton-Drake Galleries. ...
https://notjustdolls.com/product/annabelles-hugs/
SMILE, HUG ARE 'THE REAL REWARD' OF SCHOOL WORK - Sun SentinelSMILE, HUG ARE 'THE REAL REWARD' OF SCHOOL WORK - Sun Sentinel
Sandy Duva says it's a rewarding experience when she gets a smile or a hug from one of the students at Pasadena Lakes Elementary School. The Pembroke Pines resident has been volunteering in the school for three years. She dedicates about 20 hours a week to help in such activities as grading papers and photographing the school's students of the month. Duva, whose daughter, Victoria, is a fifth-grader in the school, also belongs to the Super Stars, the Pasadena Lakes club that encourages students to excel in math. She also works with students who need extra help with math, reading, spelling and English. The real reward is when a child comes up to you with a big smile and gives you a big hug and asks you if you will be in their class today, Duva says. Nothing could be more rewarding than a smile and a hug. Teachers and administrators also appreciate Duva's contributions. They express their gratitude through thank-you notes and a luncheon for volunteers. The teachers and the
https://www.sun-sentinel.com/news/fl-xpm-1996-03-10-9603070208-story.html
Hugs May Help Protect Against Colds by Boosting Social Support - Healthcanal.comHugs May Help Protect Against Colds by Boosting Social Support - Healthcanal.com
Cohen and his team chose to study hugging as an example of social support because hugs are typically a marker of having a more intimate and close relationship with another person.. We know that people experiencing ongoing conflicts with others are less able to fight off cold viruses. We also know that people who report having social support are partly protected from the effects of stress on psychological states, such as depression and anxiety, said Cohen. We tested whether perceptions of social support are equally effective in protecting us from stress-induced susceptibility to infection and also whether receiving hugs might partially account for those feelings of support and themselves protect a person against infection.. In 404 healthy adults, perceived support was assessed by a questionnaire, and frequencies of interpersonal conflicts and receiving hugs were derived from telephone interviews conducted on 14 consecutive evenings. Then, the participants were intentionally exposed to a ...
https://www.healthcanal.com/immune-system/58595-hugs-may-help-protect-against-colds-by-boosting-social-support.html
Borderline Personality Disorder: Good Will Hugging | Therapy UnpluggedBorderline Personality Disorder: Good Will Hugging | Therapy Unplugged
What are the different types of therapy hugs, long hugs, short hugs, A frame hugs, sexual hugs, bear hugs, stealth hug, epic fail hug etc.
https://blogs.psychcentral.com/unplugged/2012/08/borderline-personality-disorder-good-will-hugging/
Stroke Avoidance for Children in REpublica Dominicana (SACRED): A Prospective Research Study to Reduce Stroke in Children With...Stroke Avoidance for Children in REpublica Dominicana (SACRED): A Prospective Research Study to Reduce Stroke in Children With...
infectious disease including HIV, known allergy to hydroxyurea therapy, or malignancy). - Abnormal historical laboratory values (most recent pre-enrollment values):. 1. Anemia: Hemoglobin concentration < 6.0 gm/dL 2. Reticulocytopenia: Absolute reticulocyte count < 100 x 10˄9/L with a hemoglobin concentration < 8.0 gm/dL 3. Neutropenia: Absolute neutrophil count (ANC) < 1.0 x 10˄9/L 4. Thrombocytopenia: Platelet count < 80 x10˄9 /L 5. Known abnormal renal function (serum creatinine >2X upper limit for age AND ≥ ...
https://scdstudies.com/stroke-avoidance-for-children-in-republica-dominicana-sacred-a-prospective-research-study-to-reduce-stroke-in-children-with-sickle-cell-anemia/
Songs From His Nÿghtbird: Just A HugSongs From His Nÿghtbird: Just A Hug
When Daddy came home from work, He just wrapped me in His arms and told me that I needed a hug. It was a long hug. The kind where after a few minutes you get kind of squirmy and uncomfortable, especially when you arent really in the mood. When He let go, He explained that He had read a study that claimed hugging actually brings down elevated heart rates and can reduce blood pressure ...
https://submissivelittlegirl.blogspot.com/2014/09/just-hug.html
Hugs & Drugs Tank Top | SpreadshirtHugs & Drugs Tank Top | Spreadshirt
This Hugs & Drugs Tank Top is printed on a Tank Top and designed by t-shirt. Available in many sizes and colours. Buy your own Tank Top with a Hugs & Drugs design at Spreadshirt, your custom t-shirt printing platform!
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US Based WorldVentures Foundation Donates $100,000 To Hug It Forward Towards Education - Indias Largest CSR NetworkUS Based WorldVentures Foundation Donates $100,000 To Hug It Forward Towards Education - Indias Largest CSR Network
Donation Helps to Fund 25 Bottle Schools in Latin America INDIACSR News Network Plano, TX : WorldVentures Foundationâ„¢, the philanthropic arm of WorldVenturesâ„¢, the leading direct seller of vacation club memberships, said that it has raised and donated over $100,000 to Hug It Forward, a grass-roots organization that facilitates education and awareness by empowering communities to build schools using eco-bricks. Because of the efforts of WorldVentures Independent Representatives, Hug It Forward is now able to develop eight new schools in Guatemala. Since October 2009, the organization has completed 25 successful bottle school projects, at an average cost of $6,500 per classroom.. We are extremely proud of our Independent Representatives donating to the WorldVentures Foundation for such a worthy cause as education, live at our biggest training event of the year, WorldVentures Co-Founder and Chief Visionary Officer Wayne Nugent said. Our Representatives and DreamTripsâ„¢ Members have ...
http://indiacsr.in/us-based-worldventures-foundation-donates-100000-to-hug-it-forward-towards-education/
Start of a 2nd date, kiss on cheek, lips or just hug? - GirlsAskGuysStart of a 2nd date, kiss on cheek, lips or just hug? - GirlsAskGuys
Start of a 2nd date, kiss on cheek, lips or just hug? At the start of a 2nd date (if you havent kissed yet) but want to show you are interested and like them what is the best thing to do? Hug them, Kiss on the...... asked under Dating
https://www.girlsaskguys.com/dating/q806368-start-of-2nd-date-kiss-on-cheek-lips-or-just
Everything At One Click: The Hug - An Art of Showing How Much You Love and CareEverything At One Click: The Hug - An Art of Showing How Much You Love and Care
The last one is called the Super-Long-Oh-So-Passionate Hug. This is similar to the bear hug but it lasts longer and you cling to your loved one for several minutes, or even hours if you can handle it. I could just imagine myself doing this if I havent seen someone for a long long time. Sometimes when you miss the person you love, this is one way to show how much youve missed him. Do not do this with a person youre not in a relationship with or else it will really feel awkward or worse, embarrassing. ...
http://everythingatoneclick.blogspot.com/2010/12/hug-art-of-showing-how-much-you-love.html
Compound Report CardCompound Report Card
[ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:Hydroxyurea | DROXIA | HYDREA, Synonyms:HYDROXYUREA | HYDROXYCARBAMIDE | DROXIA | HYDREA | SQ 1089 | SQ-1089
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL467
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Clipart Vector of Kid hug heart - Little kid hugging a big heart csp8444425 - Search Illustration, Drawings and EPS Graphics...Clipart Vector of Kid hug heart - Little kid hugging a big heart csp8444425 - Search Illustration, Drawings and EPS Graphics...
Kid hug heart Vector. csp8444425 - Little kid hugging a big heart. Affordable Royalty Free Stock Photography. Downloads for just $2.50, with thousands of images added daily. Subscriptions available for just $39.00. Our stock photo image search engine contains royalty free photos, vector clip art images, clipart illustrations.
https://www.canstockphoto.com/kid-hug-heart-8444425.html
Life with the MS Hug | Multiple Sclerosis Society UKLife with the MS Hug | Multiple Sclerosis Society UK
Ann shares her experience of the infamous MS Hug, a painful condition that some people living with MS have periodically around their chest and torso.
https://mssociety.org.uk/care-and-support/online-community/community-blog/life-with-the-ms-hug
Diner Owner With Down Syndrome Serves Breakfast, Lunch and Hugs - Good News NetworkDiner Owner With Down Syndrome Serves Breakfast, Lunch and Hugs - Good News Network
Tim Harris, owner of Tims Place, is the countrys only restaurant owner with Downs Syndrome, and the joy he gets from serving people good food carries over into his diners most famous export: hugs.
https://www.goodnewsnetwork.org/diner-owner-with-down-syndrome-serves-hugs-2/
CBDs Are Like A Bear Hug to Our Nervous System | Valley Of CbdCBDs Are Like A Bear Hug to Our Nervous System | Valley Of Cbd
Cannabinoids all impact the receptors of the brain, in a means much like how opiates do. The receptors are located in numerous areas of the central nervous system, and when a cannabinoid interacts with them they alter how youre feeling or behave. Some affect moods, whereas others affect reminiscence or even pain notion. proprioceptive enter to the physique that can modulate the exercise of the PSNS and SNS, bringing the techniques into more of a balanced response and state of arousal. Light touch is often perceived as alerting and even agitating to some folks, whereas deep pressure contact is often calming and organizing to the sensory methods. While each child is different and has his or her own preferences, I contemplate deep pressure to be my go-to calming sensory technique at residence and at work. The ache and discomfort of an MS hug might have an effect on day-to-day actions, such as exercising or sleeping ...
https://www.valleyofcbd.com/cbds-are-like-a-bear-hug-to-our-nervous-system/
Bio Page for Peter HugBio Page for Peter Hug
Peter Hug has been involved in precious metals since 1974. He began gaining first-hand investment industry experience at Deak-Perera. He served as SVP at Guardian Trust Company, which became one of the largest international trading houses for precious metals. He developed the first precious metals certificate program and the first margin trading accounts for metals on the cash market. Peter has acquired extensive experience in the wholesale markets and international asset diversification. A frequent speaker at precious metals conferences and in the financial media, he is one of the handful of experts who have succeeded through multiple bull and bear cycles on the strength and skills honed during the dramatic fluctuations of the 1980s. As the Director of Kitcos Precious Metals Division, Peter develops newer and better investment options for Kitco customers. 1 877 963-NEWS. ...
https://www.kitco.com/contributors/PeterHug/
Sinfest :: View topic - Future Darwin Award winner tries to hug panda...Sinfest :: View topic - Future Darwin Award winner tries to hug panda...
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
http://www.sinfest.net/phpbb2/viewtopic.php?p=34752
Sinfest :: View topic - Future Darwin Award winner tries to hug panda...Sinfest :: View topic - Future Darwin Award winner tries to hug panda...
how surreal. it starts out so cute and funny. he just wanted to hug the panda. then he gets irate and kicks it. a moment later he is biting it in the back. you big meanie, I just wanted to huuuuug yoooouuuuu!!! ...
http://www.sinfest.net/phpbb2/viewtopic.php?p=34645
Wife Found Aneurysm in His Abdomen: It Pays To Hug Your… | IU HealthWife Found Aneurysm in His Abdomen: It Pays To Hug Your… | IU Health
Attorney Mike Horton was living with a potentially deadly abdominal aortic aneurysm. Lucky for him, his wife gave him a hug and found the pu
https://iuhealth.org/news-hub/wife-found-aneurysm-in-his-abdomen-it-pays-to-hug-your-husband
Embracing history: Man sets hugs record in VegasEmbracing history: Man sets hugs record in Vegas
(AP) -- A 51-year-old Ohio man has embraced the Valentines Day spirit faster than anyone before, giving 7,777 hugs in 24 hours for a new world record.
https://medicalxpress.com/news/2010-02-embracing-history-vegas.html
9:00 am9:00 am
So, getting back to Bessie. Bessie has now been upgraded to Bruno. Bruno also incorporates trigger points.. See the difference? This guy is oh-so-very much more…uh…specific. I could use this to my advantage.. Given how most chronic illnesses are like a box of chocolates…you neva know what youre gonna get…on any given Sunday I can now present a list.. A list of, Short Loin is out of service today. Please do not touch.. Or…Touch #2 on the Foreshank and Brisket and you die.. So, yes…it stands to reason that hugs most certainly DO hurt. Do I stop giving hugs?. NO. The physical discomfort cannot replace the emotional comfort created by getting/giving a hug.. BUT…I thought it might be beneficial to the community at large that if I were to, say…decline…a hug…that it in no way is to be considered an affront to you.. Better yet…if you are aware that the person you wish to wrap your arms around is a chronic badass…open your arms wide and wait for us to wrap around ...
http://www.lupusinterrupted.com/i-am-jacks-tender-cow/
Extreme Kindness » One Hug at a timeExtreme Kindness » One Hug at a time
Brad Stokes is sure that he can change the world with a hug.. And if it sounds like a big challenge, he is not only willing to prove it to one person, but to thousands.. Stokes - one member of the four-person Kindness Crew - demonstrated his passion for his goal to students Wednesday morning at Queneesh Elementary School as part of the Extreme Kindness Crew touring 11 Comox Valley schools this week.. Stokes is in the middle of attempting to speak to 10,000 students prior to Christmas about the value of kindness in hopes to inspire students to create their own acts of kindness towards each other and their communities.. Random acts of extreme kindness is something you like to do while making a positive impact on the community, he said.. The Kindness Crew also includes Val Litwin, Erik Hanson and Chris Bratseth; four friends who, motivated by the 9/11 attacks, travel the world promoting kindness to make the community a better place, and in turn, it makes you happier and healthier, noted ...
http://extremekindness.com/?p=492
Amoeba Hugs Pillow - Beatrice the BiologistAmoeba Hugs Pillow - Beatrice the Biologist
Usually ships in 3-5 business days. Amoeba hugs, you know, are often fatal. Show your love of amoebas and phagocytosis with this oh-so-fashionable pillow. • 18
https://shop.beatricebiologist.com/collections/amoeba-hugs/products/amoeba-hugs-pillow
Halo 3: Mythic Skull | Level Halo. Hug the right wall out of… | FlickrHalo 3: Mythic Skull | Level Halo. Hug the right wall out of… | Flickr
Level Halo. Hug the right wall out of the ship. Just in the entrance of the cave, to the right theres a smaller cave that holds this skull.
https://www.flickr.com/photos/commorancy/1678605794/
Little Girl Hugs A Rabbit stock photo | iStockLittle Girl Hugs A Rabbit stock photo | iStock
Download this Little Girl Hugs A Rabbit photo now. And search more of the webs best library of royalty-free stock images from iStock.
https://www.istockphoto.com/photo/little-girl-hugs-a-rabbit-gm157742569-21825654?st=0d6ae41
Watch this: Becky & Joe release creepy sequel to viral puppet video Dont Hug Me Im Scared - The VergeWatch this: Becky & Joe release creepy sequel to viral puppet video Dont Hug Me Im Scared - The Verge
Becky Sloan and Joseph Pelling are back and disturbing as ever with Dont Hug Me Im Scared 2, the sequel to the creepy viral video they released in 2011. The first video taught puppet characters...
https://www.theverge.com/2014/1/7/5284094/becky-and-joe-release-dont-hug-me-im-scared-2
Research RecommendationsResearch Recommendations
See the ASH Agenda for Hematology Research and research recommendations on sickle cell disease, lymphoma, the Moonshot Initiative, and more.
https://www.hematology.org/Research/Recommendations/
Testicular Toxicity Characters And Mechanisms Of Hydroxyurea On Rats | 69248Testicular Toxicity Characters And Mechanisms Of Hydroxyurea On Rats | 69248
Objective: Apoptosis plays a dominant role in both spontaneous spermatogenesis and germ cell death. This study was aimed to investigate the functions of relate...
https://www.omicsonline.org/proceedings/testicular-toxicity-characters-and-mechanisms-of-hydroxyurea-on-rats-69248.html
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Hispanic Real Estate Brokers Association (HREBA) : News & Events : NewsroomHispanic Real Estate Brokers Association (HREBA) : News & Events : Newsroom
They tell you no, run away from you and use up all of your money. They throw a fit, leave a mess and seem to take extra long to get anything done. But, they also cuddle with you, love to play games and ask to read a book. They tell you they love you and look up to you as their hero. Theres no doubt about it: kids are a challenge. If youre a parent, you know how grueling the role of caregiver can be.. But, being a parent is also the most rewarding experience in life. Especially if you strive to live an altruistic lifestyle, theres nothing quite so altruistic as parenting. Kids rely on you for their every need, and you show them how much you care by providing, serving and giving affection. And what better way to show affection than by celebrating today-Global Hug Your Kids Day!. Global Hug Your Kids Day is a day we can all get our arms around. Celebrated on the third Monday of July, the purpose of today is simple: hug your kids. Show them how much you love, comfort and support them by giving ...
https://www.hrebaconnect.org/news-events/newsroom.html/article/2018/07/16/celebrating-global-hug-your-kids-day
Whiskers-N-Paws : News & Events : NewsroomWhiskers-N-Paws : News & Events : Newsroom
They tell you no, run away from you and use up all of your money. They throw a fit, leave a mess and seem to take extra long to get anything done. But, they also cuddle with you, love to play games and ask to read a book. They tell you they love you and look up to you as their hero. Theres no doubt about it: kids are a challenge. If youre a parent, you know how grueling the role of caregiver can be.. But, being a parent is also the most rewarding experience in life. Especially if you strive to live an altruistic lifestyle, theres nothing quite so altruistic as parenting. Kids rely on you for their every need, and you show them how much you care by providing, serving and giving affection. And what better way to show affection than by celebrating today-Global Hug Your Kids Day!. Global Hug Your Kids Day is a day we can all get our arms around. Celebrated on the third Monday of July, the purpose of today is simple: hug your kids. Show them how much you love, comfort and support them by giving ...
https://www.whiskers-n-paws.org/news-events/newsroom.html/article/2018/07/16/celebrating-global-hug-your-kids-day
Does Cuddling Make You Fall In Love? - thecostofplas.comDoes Cuddling Make You Fall In Love? - thecostofplas.com
Yes but not all the time, you only get aroused when the hug is with someone you are very sexually attracted to or someone who rekindles some sex appeal to you. It also depends on what is in someones mind at the time of the hug. A hug that is followed by an eyes contact and smike mostly turns guys on ...
https://thecostofplas.com/qa/does-cuddling-make-you-fall-in-love.html
this is what make me hug you and donate - Forum on Fatigue and Anemia - TheBody.comthis is what make me hug you and donate - Forum on Fatigue and Anemia - TheBody.com
Hello, Thanks for your thanks, very kind comments, the cyber-hug and the donation to the Robert James Frascino AIDS Foundation. All are warmly appreciated. Im delighted you too have found your...
http://www.thebody.com/Forums/AIDS/Fatigue/Q201897.html
Paul RolanPaul Rolan
... an antisickling agent, using a novel surrogate marker". In 1994 he moved into the role of Medical Director at the contract ...
https://en.wikipedia.org/wiki/Paul_Rolan
List of MeSH codes (D27)List of MeSH codes (D27)
... hematologic agents MeSH D27.505.954.502.119 - anticoagulants MeSH D27.505.954.502.135 - antisickling agents MeSH D27.505. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)
Obafemi Awolowo UniversityObafemi Awolowo University
An underlying purpose of these expansion was the view that education was an important agent of transformation and development. ... the potential anti-sickling properties of fagara zanthoxylloides, mechanisms of chloroquine -induced pruritus, a ...
https://en.wikipedia.org/wiki/Obafemi_Awolowo_University
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects T. Kassa, M. ... Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects ...
https://pubs.rsc.org/en/Content/ArticleLanding/MT/2017/C7MT00104E
PRIME PubMed | Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG...PRIME PubMed | Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG...
... site-specific acetylating agent toward the 2,3-DPG binding site in hemoglobin S. Download Prime PubMed App to iPhone, iPad, or ... Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in ... "Methyl Acetyl Phosphate, a New Type of Antisickling Agent: Site-specific Acetylating Agent Toward the 2,3-DPG Binding Site in ... Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in ...
https://www.unboundmedicine.com/medline/citation/3239714/Methyl_acetyl_phosphate_a_new_type_of_antisickling_agent:_site_specific_acetylating_agent_toward_the_23_DPG_binding_site_in_hemoglobin_S_
Antisickling Agents | REACHAntisickling Agents | REACH
"Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these ... "Antisickling Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Antisickling Agents" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Antisickling Agents". ...
https://reach.sickkids.ca/display/6334
Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood JournalBeyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood Journal
Hemoglobin modification and antisickling agents. Carbon monoxide (CO) is a potent antisickling agent, because it attaches to Hb ... Induction of HbF and antisickling agents. Irreversible sickling does not appear to be the driving factor for red cell adhesion ... Drugs that increase HbF levels are the archetypal antisickling agents, because HbF interferes with polymerization of HbS, ... Anticoagulants and antiplatelet agents. Although coagulation is chronically activated in SCD,79⇓⇓⇓-83 no specific clinical ...
http://www.bloodjournal.org/content/127/7/810?sso-checked=true
A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable...A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable...
Antisickling Agents. Additional relevant MeSH terms: Anemia, Sickle Cell. Anemia, Hemolytic, Congenital. Anemia, Hemolytic. ... ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. ...
https://clinicaltrials.gov/ct2/show/NCT01597401?recr=Open&cond=%22Anemia%2C+Sickle+Cell%22&rank=14
A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With...A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With...
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ... Anti-HIV Agents. Anti-Retroviral Agents. Antiviral Agents. Anti-Infective Agents. Antimetabolites. Reverse Transcriptase ... Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic ...
https://clinicaltrials.gov/show/NCT00002176?order=4
Hydroxyurea Management in Kids: Intensive Versus Stable Dosage Strategies - Full Text View - ClinicalTrials.govHydroxyurea Management in Kids: Intensive Versus Stable Dosage Strategies - Full Text View - ClinicalTrials.gov
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ...
https://www.clinicaltrials.gov/ct2/show/study/NCT03020615
Current version of study NCT03183375 on ClinicalTrials.govCurrent version of study NCT03183375 on ClinicalTrials.gov
Antineoplastic Agents. Antisickling Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. Nucleic Acid ...
https://www.clinicaltrials.gov/show/NCT03183375
The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde<...The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde<...
Manning, J. M., & Acharya, A. S. (1984). The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde ... Manning, JM & Acharya, AS 1984, The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde, ... Fingerprint Dive into the research topics of The mechanism of action of two anti-sickling agents: Sodium cyanate and ... The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde. American Journal of Pediatric ...
https://einstein.pure.elsevier.com/en/publications/the-mechanism-of-action-of-two-anti-sickling-agents-sodium-cyanat-2
Sickle-Cell Disease Co-Management, Health Care Utilization, and Hydroxyurea UseSickle-Cell Disease Co-Management, Health Care Utilization, and Hydroxyurea Use
Antisickling Agents * Hydroxyurea Grant support * R18 HS024501/HS/AHRQ HHS/United States ...
https://pubmed.ncbi.nlm.nih.gov/31907250/
Sickle cell diseaseSickle cell disease
Antisickling Agents / therapeutic use * Blood Transfusion / methods * Cerebrovascular Disorders / prevention & control * ...
https://pubmed.ncbi.nlm.nih.gov/28159390/?dopt=Abstract
Anti-sickling Herbs | SpringerLinkAnti-sickling Herbs | SpringerLink
Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. Pharmacogn Rev 7(13):53-60PubMed ... Soforowa EA (1975) Isolation and characterization of an anti-sickling agent from Fagara zanthoxyloides. Lloydia 38:169-171 ... Adesanya SA, Idowu TB, Elujoba AA (1988) Anti-sickling activity of Adansonia digitata. Planta Med 54(4):374PubMedGoogle Scholar ... Mojisola OC, Adebolu EA, Alani DM (2008) Anti-sickling properties of Carica papaya Linn. J Nat Prod 1:56-66Google Scholar ...
https://link.springer.com/chapter/10.1007%2F978-3-030-04408-4_12
Biochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st EditionBiochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st Edition
Dichloromethane as an Antisickling Agent in Sickle Cell Hemoglobin. Fourier Transform Infrared Spectroscopy of Hemoglobin. A ...
https://www.elsevier.com/books/biochemical-and-clinical-aspects-of-hemoglobin-abnormalities/caughey/978-0-12-164350-8
SWISS-MODEL Template Library | 3r5i.1SWISS-MODEL Template Library | 3r5i.1
Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 ... Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312. Coordinates. PDB Format Method. X ... Highly Potent Antisickling Agents. To be Published Release Date. 2011-04-06. Peptides. Hemoglobin subunit alpha: AC. Hemoglobin ...
https://swissmodel.expasy.org/templates/3r5i.1
Show the full text of the articleShow the full text of the article
Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
https://www.tfljournal.org/article.php?story=20080918151543875
Trees for Life Journal - Proximate Composition and In-vitro Anti-sickling Property of Nigerian Cyperus esculentus (Tiger Nut...Trees for Life Journal - Proximate Composition and In-vitro Anti-sickling Property of Nigerian Cyperus esculentus (Tiger Nut...
Ekeke, G.I and Shode, F.C. (1990) Phenylalanine is the predominant anti-sickling agent in Cajanus cajan seed extract. Planta ... been established as both nutritious and possessing anti-sickling activity, although the active anti-sickling principles have ... Agbai O (1986) Anti-sickling effects of dietary thiocyanate in prophylactic control of sickle cell anemia. Journal of the ... Dalziel JM (1937) Useful plant of West Tropical Africa. Conden Crown Agents, UK. 326-336. ...
https://www.tfljournal.org/article.php?story=20080918151543875&mode=nested
D Category Names List - Drug Information Portal - U.S. National Library of MedicineD Category Names List - Drug Information Portal - U.S. National Library of Medicine
Desickling Agents (0) see Antisickling Agents. Designer Drug (1). Detergents (31) • Purifying or cleansing agents, usually ... Defoaming Agents (0) see Antifoaming Agents. Defoliants, Chemical (3) • Herbicides that remove leaves from trees and growing ... Dopamine Agents (151) • Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on ... Dermatologic Agents (125) • Drugs used to treat or prevent skin disorders or for the routine care of skin. MeSH ...
https://druginfo.nlm.nih.gov/drugportal/drug/categories/d
Dr. John Reed, MD - Greenville, NC - Nephrology | Healthgrades.comDr. John Reed, MD - Greenville, NC - Nephrology | Healthgrades.com
A Single Dose Pharmacokinetic Study of the Antisickling Agent Cetiedil, 1983. *Nutrition and Sickle Cell Disease, 1986 ...
https://www.healthgrades.com/physician/dr-john-reed-xr5ht
Stratene (Cetiedil Citrate) Gerda LaboratoiresStratene (Cetiedil Citrate) Gerda Laboratoires
Vasodilators and anti-sickling agents. Indications and usages, anatomical therapeutic chemical and diseases classification ...
https://drugs-about.com/drugs-s/stratene.html
Evaluating the Safety and Efficacy of Hemoglobin-based Blood Substitutes | FDAEvaluating the Safety and Efficacy of Hemoglobin-based Blood Substitutes | FDA
Targeting betaCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.. Kassa T, ... Interactions of an anti-sickling drug with hemoglobin in red blood cells from a patient with sickle cell anemia.. Strader MB, ... Antisickling drugs targeting betaCys93 reduce iron oxidation and oxidative changes in sickle cell hemoglobin.. Kassa T, Wood F ...
https://www.fda.gov/vaccines-blood-biologics/biologics-research-projects/evaluating-safety-and-efficacy-hemoglobin-based-blood-substitutes
Award Data | SBIR.govAward Data | SBIR.gov
Aruvant Sciences Presents Data from Ongoing Clinical Study of Lentiviral Gene Therapy RVT-1801 for Sickle Cell Disease at 60th...Aruvant Sciences Presents Data from Ongoing Clinical Study of Lentiviral Gene Therapy RVT-1801 for Sickle Cell Disease at 60th...
Patient 1 exhibits 31.5% of total Hb as anti-sickling hemoglobins (HbFG16D + HbF + HbA2) with 20.2% of total Hb from HbFG16D at ... regimen involving melphalan and other agents. This conditioning regimen, which is investigational and subject to further study ... Patient 2 exhibits 22.2% of total Hb as anti-sickling hemoglobins with 8.6% of total Hb from HbFG16D at 12 months after ... Fetal hemoglobin has very potent anti-sickling properties relative to adult hemoglobin (HbA). RVT-1801 uses a patented, ...
https://www.prnewswire.com/news-releases/aruvant-sciences-presents-data-from-ongoing-clinical-study-of-lentiviral-gene-therapy-rvt-1801-for-sickle-cell-disease-at-60th-annual-meeting-of-the-american-society-of-hematology-300759452.html
Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to...Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to...
This second moiety is, for example, a drug carrier and/or a therapeutic agent such as, for instance, an anti-inflammatory agent ... In both patients, significant anti-sickling effects and prolongation of red cell survival was observed. Beutler did not ... Besides such inert diluents, compositions can also include adjuvants, such as wetting agents, emulsifying and suspending agents ... Other auxiliary, non-toxic agents may be included, for example, polyethylene glycols or wetting agents. ...
http://www.freepatentsonline.com/y2006/0148900.html
The American Journal of Tropical Medicine and Hygiene | In Vitro Activity of Artemisinin in Combination with Clotrimazole or...The American Journal of Tropical Medicine and Hygiene | In Vitro Activity of Artemisinin in Combination with Clotrimazole or...
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin ... Antimicrob Agents Chemother 48 : 4097-4102.. * Berenbaum MC, 1978. A method for testing synergy with any number of agents. J ... Antimicrob Agents Chemother 41 : 2345-2351.. * Hatabu T, Takada T, Taguchi N, Suzuki M, Sato K, Kano S, 2005. Potent ... Antimicrob Agents Chemother 46 : 1510-1515.. * Sannella R, Messori L, Casini A, Vincieri FF, Bilia AR, Majori G, Severini C, ...
http://www.ajtmh.org/content/journals/10.4269/ajtmh.2008.78.721
WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...
Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues. Abraham, D.J., Mehanna, A.S., ... Agents Chemother. (1998) [Pubmed]. *Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic ... Modification by pharmacologic agents. Castor, C.W. Arthritis Rheum. (1975) [Pubmed]. *Oxidative stress and Mrp2 internalization ... inhibitory concentration values ranging from 0.3 to 6.0 microM and has been shown to restore sensitivity to alkylating agents ...
https://www.wikigenes.org/e/chem/e/3278.html
Sickle Cell Anemia | Grand Strand HealthSickle Cell Anemia | Grand Strand Health
Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
https://grandstrandmed.com/hl/?/11561/sickle-cell-disease&com.dotmarketing.htmlpage.language=1
Oxidative Effects of Gemfibrozil on Anion Influx and Metabolism in Normal and Beta-Thalassemic Erythrocytes: Physiological...Oxidative Effects of Gemfibrozil on Anion Influx and Metabolism in Normal and Beta-Thalassemic Erythrocytes: Physiological...
Physiological and X-ray studies of potential antisickling agents. Abraham, DJ; Perutz, MF; Phillips, SE ...
https://www.deepdyve.com/lp/springer_journal/oxidative-effects-of-gemfibrozil-on-anion-influx-and-metabolism-in-zmiNIU82Yf
Sickle Cell Anemia | Doctors HospitalSickle Cell Anemia | Doctors Hospital
Sickle Cell Anemia and Antisickling Agents then and now. Curr Med Chem. 2001;8:79-88. ...
https://doctors-hospital.net/hl/?/11561/sickle-cell-anemia&com.dotmarketing.htmlpage.language=1
Traditional Herbal Management of Sickle Cell Anemia: Lessons from NigeriaTraditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria
K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit (Carica papaya)," Transactions of the Royal ... G. I. Ekeke and F. O. Shode, "Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract," Planta Medica ... J. A. Walder, R. H. Zaugg, R. S. Iwaoka, W. G. Watkin, and I. M. Klotz, "Alternative aspirins as antisickling agents: acetyl-3, ... K. Gamaniel, S. Amos, P. Akah et al., "Pharmacological profile of NIPRD 94/002/1-0: a novel herbal antisickling agent," Journal ...
https://www.hindawi.com/journals/anemia/2012/607436/ref/
HydroxyureaVitroAssaysHemoglobinExtractsMeSHCompoundsExtractAnemiaTherapeutic agentsIsolationUnripeDosagePotent anti-sicklSpecificityClinical trialsDrugsTherapyAdultActivityMyelosuppressiveSearchPotentialUrineCyanatePropertiesTherapiesStudyFoundBloodTopicReviewDevelopmentActivitiesMechanismPatientsMethodPublicationsPrevent
Hydroxyurea3
  • But findings from a new study, presented here at the plenary session of the American Society Hematology (ASH) 57th Annual Meeting, showed that oral agent hydroxyurea was noninferior and possibly superior to long-term transfusions. (scinfo.org)
  • 3. More than two hospital admissions for painful VOC in the prior 12 months, whether on any anti-sickling agents (e.g. hydroxyurea, L-glutamine, or transfusion therapy) or not. (ichgcp.net)
  • The only existing therapy approved for SCD is the anti-cancer agent hydroxyurea (HU). (grantome.com)
Vitro2
  • Structural and in Vitro Chracterization of Pyridyl Derivatives of Benzaldehydes : Highly Potent Antisickling Agents. (expasy.org)
  • This study validates for the first time the in vitro antisickling activity of U. molundense. (scirp.org)
Assays2
  • ous extract obtained and used for antisickling assays. (who.int)
  • The crude CA extract and fractions were subjected to inhibitory and reversal antisickling assays at 0.25-4.00 mg/mL concentration range. (jppres.com)
Hemoglobin6
  • Methyl Acetyl Phosphate, a New Type of Antisickling Agent: Site-specific Acetylating Agent Toward the 2,3-DPG Binding Site in Hemoglobin S." The American Journal of Pediatric Hematology/oncology, vol. 10, no. 4, 1988, pp. 348-50. (unboundmedicine.com)
  • Pharmacodynamic effects will be assessed by measuring partial pressure of oxygen at which 50% of hemoglobin is saturated with oxygen (p50) while breathing normal air, blood oxygen levels (SpO2), ex-vivo antisickling effects in a hypoxic environment, and by imaging related changes in tissue blood flow and oxygen levels. (clinicaltrials.gov)
  • Preclinical data indicated that the therapy is a potent anti-sickling agent with a high specificity for hemoglobin. (scinfo.org)
  • We demonstrate that polymerization of sickle hemoglobin (HbS) is responsible for this growth arrest of intraerythrocytic P. falciparum parasites, with normal hemoglobin digestion and growth restored in the presence of carbon monoxide, a gaseous antisickling agent. (pnas.org)
  • Solubility determination (Csat) of deoxy hemoglobin S gels demonstrated that HN2 markedly inhibited the polymerization of HbS, was significantly more effective than potassium cyanate, and is among the most potent anti-sickling agents thus far reported. (unboundmedicine.com)
  • HbS Aggregation Is An Inefficient Process Attempts to rationally design antisickling agents possess often viewed the sickle hemoglobin both as the drug target as well as the starting point for lead finding. (cancerresources.com)
Extracts3
  • All tested extracts displayed antisickling activity. (scirp.org)
  • hexane, dichloromethane and ethyl acetate crude extracts of Syzygium guineense of DRC, betulinic acid, betulinic acid acetate and maslinic acid showed a high antisickling activity, more than 70% of normalization. (ukzn.ac.za)
  • Others crude extracts and pure isolated compounds were found to be non-active antisickling agents. (ukzn.ac.za)
MeSH1
  • Antisickling Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
Compounds2
  • Bioactivity-directed isolation of antisickling compounds from Cnidoscolus acontifolius (Mill. (jppres.com)
  • To evaluate the antisickling potential of Cnidoscolus aconitifolius leaf extract, determine the most active fraction, and isolate the putative compounds. (jppres.com)
Extract2
  • K. D. Thomas and B. Ajani, "Antisickling agent in an extract of unripe pawpaw fruit ( Carica papaya )," Transactions of the Royal Society of Tropical Medicine and Hygiene , vol. 81, no. 3, pp. 510-511, 1987. (hindawi.com)
  • The study concluded that the ethyl acetate fraction of the ethanol extract of C. aconitifolius has the highest antisickling property and identified tetramethylbicosahydropicen-3-ol as a potential antisickling agent. (jppres.com)
Anemia2
  • There is continuous search for therapeutic agents from indigenous plants that can be employed in the treatment of sickle cell anemia. (jppres.com)
  • Existe una búsqueda continua de agentes terapéuticos a partir de plantas autóctonas que puedan emplearse en el tratamiento de la anemia de células falciformes. (jppres.com)
Therapeutic agents2
  • DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. (sbir.gov)
  • Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F. Traditional medicine as a source of new therapeutic agents against psoriasis. (koreascience.or.kr)
Isolation1
  • E. A. Sofowora, "Isolation and characterization of an antisickling agent from the root of Fagara zanthoxyloides," in Proceedings of a Symposium Fagara and the Red Blood Cell , A. Sofowora and A. I. Sodeye, Eds. (hindawi.com)
Unripe1
  • The unripe fruit contains glycine, phenylalanine and try- ptophan with reported antisickling properties (Pizzorno solution (0.6 ml) was introduced gently under the liquid paraffin. (who.int)
Dosage1
  • A prevailing question about the suitability from the HbS molecule as focus on for drug advancement is due to the perceived restriction enforced by its high articles level in guy (about 450g) [61], recommending an intolerably high dosage of antisickling substance would Ivabradine HCl (Procoralan) be necessary to obtain clinically useful levels of inhibition [85]. (cancerresources.com)
Potent anti-sickl1
  • And Xickle® RBC-Plusâ„¢ is a more potent anti-sickling agent than Niprisan, a drug approved to treat sickle cell disease in Nigeria. (xickle.com)
Specificity1
  • New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors. (umassmed.edu)
Clinical trials1
  • To AesRx's knowledge, Aes-103 is the only direct anti-sickling agent in or near clinical trials. (grantome.com)
Drugs2
  • Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. (nih.gov)
  • Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (umassmed.edu)
Therapy2
  • Previous therapy with agents with significant systemic myelosuppressive, neurotoxic, pancreatotoxic, hepatotoxic or cytotoxic potential within 3 months of study start or the expected need for such therapy at the time of enrollment. (clinicaltrials.gov)
  • Other areas of investigation included butanol vapor therapy in pulmonary edema and non-covalent antisickling agents for sickle cell hemoglobinopathy. (ecu.edu)
Adult1
  • The FDA granted priority review to a supplemental biologics license application for the anti-PD-1 agent pembrolizumab for adult and pediatric patients with relapsed/refractory primary. (ashclinicalnews.org)
Activity1
  • Antileishmanial activity of amphotericin and other antifungal agents entrapped in liposomes. (ajtmh.org)
Myelosuppressive1
  • The principal use of HU has been as a myelosuppressive agent in the myeloproliferative syndromes. (mjhid.org)
Search1
  • Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. (springer.com)
Potential1
  • Design, synthesis, and testing of potential antisickling agents. (springer.com)
Urine1
  • Agents that promote the excretion of urine through their effects on kidney function. (nih.gov)
Cyanate1
  • Manning, JM & Acharya, AS 1984, ' The mechanism of action of two anti-sickling agents: Sodium cyanate and glyceraldehyde ', American Journal of Pediatric Hematology/Oncology , vol. 6, no. 1, pp. 51-54. (elsevier.com)
Properties1
  • Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (nih.gov)
Therapies1
  • Whilst the treatment paradigms fundamentally vary between different aetiologies, there are overlaps with pharmacological regimes in immunosuppressive agents and anti-platelet therapies. (bvsalud.org)
Study3
  • These agents may be continued during the study period. (ichgcp.net)
  • However, subjects are not allowed to be started on any of these agents during the study period. (ichgcp.net)
  • The present study was carried out with the aim of evaluating the chemical composition and bioactivity of Uvariodendron molundense against Sickle cell disease and associated pathogenic bacteria agents. (scirp.org)
Found2
  • A machine for the extracorporeal delivery of covalent anti-sickling agents has been described by Babb and coworkers and this therapeutic modality has been found feasible by others. (unboundmedicine.com)
  • 10 ] In addition to its use as an anti-cancer agent, HU has found some marginal applications in dermatology. (mjhid.org)
Blood1
  • Xickle ® RBC-Plusâ„¢ guards against those agents that can distort red blood cells and cause them to clog blood vesicles and cause pain and organ degeneration and possible organ failure. (xickle.com)
Topic1
  • This graph shows the total number of publications written about "Antisickling Agents" by people in this website by year, and whether "Antisickling Agents" was a major or minor topic of these publications. (sickkids.ca)
Review2
  • To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. (pianolarge.tk)
  • Areas covered: We review recent advances in pharmacotherapy for SCD and summarize promising synthetic agents that are in late-stage development (phase 3) for SCD. (readbyqxmd.com)
Development1
  • We will continue the development of nitrogen mustards and alkylureas as antisickling agents. (elsevier.com)
Activities1
  • The antisickling and antibacterial activities were assessed using Emmel and micro-dilution methods respectively. (scirp.org)
Mechanism1
  • The underlying neologismen wirkung viagra mechanism is sparse for taste (primojel) as disintegration agents. (mnscha.org)
Patients3
  • Both patients received a patient-specific AruLiteâ„¢ reduced intensity conditioning (RIC) regimen involving melphalan and other agents. (prnewswire.com)
  • The management of antithrombotic agents for patients undergoing GI endoscopy. (umassmed.edu)
  • In a phase I trial of patients with relapsed/refractory peripheral T-cell lymphoma (PTCL), combining romidepsin and pralatrexate - two agents approved by the U.S. (ashclinicalnews.org)
Method1
  • A method for testing synergy with any number of agents. (ajtmh.org)
Publications1
  • Below are the most recent publications written about "Antisickling Agents" by people in Profiles. (sickkids.ca)
Prevent1
  • Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions. (sickkids.ca)
Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood Journal
Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease | Blood Journal (bloodjournal.org)
Current version of study NCT01506544 on ClinicalTrials.gov
Current version of study NCT01506544 on ClinicalTrials.gov (clinicaltrials.gov)
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ...
Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects - Metallomics ... (pubs.rsc.org)
Anti-sickling Herbs | SpringerLink
Anti-sickling Herbs | SpringerLink (link.springer.com)
Biochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st Edition
Biochemical and Clinical Aspects of Hemoglobin Abnormalities - 1st Edition (elsevier.com)
PRIME PubMed | Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG...
PRIME PubMed | Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG... (unboundmedicine.com)
WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p...
WikiGenes - Edecrin - 2-[2,3-dichloro-4-(2-methylidenebutanoyl)p... (wikigenes.org)
Sickle Cell Anemia | Grand Strand Health
Sickle Cell Anemia | Grand Strand Health (grandstrandmed.com)
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease | Blood...
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease | Blood... (bloodjournal.org)
Vitamin B6<...
Vitamin B6<... (evitamins.com)
Sickle Cell Newsletter for December 2015 - Sickle Cell Information Center
Sickle Cell Newsletter for December 2015 - Sickle Cell Information Center (scinfo.org)
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition | PNAS
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition | PNAS (pnas.org)
Anamu (Petiveria alliacea)- Database file in the Tropical Plant Database
Anamu (Petiveria alliacea)- Database file in the Tropical Plant Database (rain-tree.com)
Pharmacogn Rev., Vol 7, Issue 13, 2013 | Pharmacognosy Reviews
Pharmacogn Rev., Vol 7, Issue 13, 2013 | Pharmacognosy Reviews (phcogrev.com)
Kakawate / Madre cacao / Gliricidia sepium: Herbal Therapy / Philippine Medicinal Herbs / Alternative Medicine in the...
Kakawate / Madre cacao / Gliricidia sepium: Herbal Therapy / Philippine Medicinal Herbs / Alternative Medicine in the... (stuartxchange.org)
Carlo Brugnara, MD | Boston Children's Hospital
Carlo Brugnara, MD | Boston Children's Hospital (childrenshospital.org)
JCI Insight - Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell...
JCI Insight - Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell... (insight.jci.org)
Antisickling Agents | REACH
Antisickling Agents | REACH (reach.sickkids.ca)