Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Metabolic Clearance Rate: Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.Sparteine: A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.Glucaric Acid: A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Trimethadione: An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Heparinoids: Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)Liver Function Tests: Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.Dimethadione: An anticonvulsant that is the active metabolite of TRIMETHADIONE.Occupational Medicine: Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.

Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining. (1/491)

BACKGROUND AND PURPOSE: After short periods of ischemia, commonly used staining methods yield only moderate differences in optical contrast between normal and damaged brain tissue when gray-scale images are used for computer-assisted image analysis. We describe a high-contrast silver infarct staining (SIS) method that allows an early delineation of ischemic tissue as soon as 2 hours after middle cerebral artery occlusion (MCAO) in rat brain cryosections. METHODS: Rats were subjected to permanent MCAO for 2, 4, 6, and 48 hours. The optical densities were quantified in nonischemic white and gray matter and in damaged tissue from gray-scale images of serial sections with the use of a video camera-based image analyzing system. SIS, hematoxylin-eosin, Nissl, and nitroblue tetrazolium stainings were performed in cryosections, and 2,3, 5-triphenyltetrazolium hydrochloride (TTC) staining was performed in unfrozen vibratome sections. In addition, the range of reduced cerebral blood flow (CBF) in areas demarcated by SIS was determined in iodo[14C]antipyrine autoradiograms of adjacent cryosections. RESULTS: At all times after MCAO, only SIS showed significantly (P<0.01) lower optical densities in damaged than in normal brain tissue for both white and gray matter. TTC staining was as effective as SIS 6 and 48 hours after MCAO. The tightest correlation between areas of reduced SIS and of reduced CBF was found at a mean ischemic CBF of 22.3 mL/100 g per minute. This corresponds to a CBF range of 0 to 44 mL/100 g per minute in areas of reduced SIS. CONCLUSIONS: In contrast to other staining methods, SIS allows a reliable delineation of ischemic brain tissue (core plus penumbra) from nonischemic white and gray matter of rat brain cryosections as soon as 2 hours after MCAO.  (+info)

Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat. (2/491)

Studies with positron-emission tomography have indicated that muscarinic acetylcholine receptors may be involved in the mechanism of enhancement of cerebral blood flow (CBF) by neuronal functional activation. We examined the effects of muscarinic receptor blockade by scopolamine on the local CBF responses to vibrissal stimulation in the whisker-to-barrel cortex sensory pathway in unanesthetized rats. Local CBF was measured by the quantitative autoradiographic [(14)C]iodoantipyrine method. Scopolamine (0.4 or 0.8 mg/kg) was injected i.v. 30 min before measurement of local CBF; control rats received equivalent volumes of physiological saline. Vibrissae on the left side of the face were stroked continuously throughout the 1-min period of measurement of CBF. Local CBF was determined bilaterally in four structures of the pathway, i.e., spinal and principal sensory trigeminal nuclei, ventral posteromedial thalamic nucleus, and barrel field of the sensory cortex, as well as in four representative structures unrelated to the pathway. The higher dose of scopolamine raised baseline CBF in the two trigeminal nuclei, but neither dose diminished the percentage of increases in local CBF because of vibrissal stimulation in any of the stations of the pathway. These results do not support involvement of muscarinic receptors in the mechanism of enhancement of local CBF by functional neuronal activation, at least not in the whisker-barrel cortex sensory pathway in the unanesthetized rat.  (+info)

Cerebrovascular reactivity to CO(2) and hypotension after mild cortical impact injury. (3/491)

Cerebrovascular reactivity to CO(2) or hypotension was studied in vivo and in vitro [pressurized arteries ( approximately 82 micrometer) and arterioles ( approximately 30 micrometer)] at 1 h after mild controlled cortical impact (CCI) injury in rats. The cortical perfusion response [assessed using laser-Doppler flowmetry (LDF)] to altered CO(2) was diminished (up to 81%) after mild CCI injury. The responses to CO(2) alterations in arteries and arterioles isolated from the injured cortex were similar to responses in vessels isolated from sham-injured animals. After mild CCI injury, the autoregulatory response to hypotension (measured using LDF) was maintained or even enhanced, depending on the method used to measure the response. Vessels isolated from the injury site showed a response to changes in pressure similar to that in vessels isolated from sham-injured rats. We conclude that mild CCI injury produces complicated alterations in cerebrovascular control. Whereas the autoregulatory response to hypotension was maintained or even enhanced, the in vivo vascular response to CO(2) was severely compromised. The altered response to CO(2) was not caused by an intrinsic vascular perturbation but rather an altered milieu after mild CCI injury.  (+info)

Direct detection of antipyrine metabolites in rat urine by (13)C labeling and NMR spectroscopy. (4/491)

Antipyrine is a useful probe to evaluate variation of in vivo activities of oxidative hepatic drug-metabolizing enzymes. Here we describe a new approach using (13)C labeling and NMR spectroscopy for the direct and simultaneous detection of all phase I and phase II metabolites of antipyrine in rat urine. [C-methyl-(13)C]Antipyrine was synthesized and administered orally to rats (100 mg/kg), and the 0- to 24-h postdose urine was analyzed by 100-MHz (13)C NMR spectroscopy under the conditions of distortionless enhancement by polarization transfer without any pretreatments such as deconjugation, chromatographic separation, and solvent extraction. Consequently, all the major metabolites in urine were successfully detected with favorable signal-to-noise ratios in the limited acquisition time (30 min). The assignments of the resonances were performed by enzymic modification and spiking authentic samples. The reproducibility of the NMR detection was sufficient for the quantitative evaluation of the metabolic profile. Effects of 3-methylcholanthrene on antipyrine metabolism were examined by this approach to evaluate variation of in vivo phase I and phase II metabolism of antipyrine in rats. The present approach is useful and practical to evaluate variation of in vivo activities of conjugation enzymes as well as oxidation enzymes responsible for the formation of antipyrine metabolites in rats. This direct approach would enhance the value of the antipyrine test because of the simplicity and convenience.  (+info)

Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide. (5/491)

Klebsiella pneumoniae endotoxin has been found to decrease hepatic P450-mediated drug-metabolizing enzyme activity in a time-dependent manner. In this study, we investigated the role of nitric oxide (NO) in the decrease in hepatic drug-metabolizing enzyme activity caused by endotoxin in vivo. We measured in vivo pharmacokinetic parameters of antipyrine in rats treated with endotoxin and/or a selective inhibitor of inducible NO synthase (iNOS), S-methylisothiourea. Intraperitoneal injection of endotoxin (1 mg/kg of body weight) dramatically decreased the systemic clearance of antipyrine, reflecting reduced hepatic drug-metabolizing enzyme activity, and significantly increased the level of nitrite and nitrate (NOx) in the plasma. S-Methylisothiourea (10 mg/kg) reversed this decreasing antipyrine clearance and reduced the level of NOx in plasma. Repeated injections of an NO donor, (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK-409; 10 mg/kg), at a dose which maintained plasma NOx at the same levels as those caused by endotoxin injection, also decreased the systemic clearance of antipyrine. These findings suggest that the overproduction of NO observed in this animal model is at least partially responsible for the significant reduction in the hepatic drug-metabolizing enzyme activity that may happen in a gram-negative bacterial infection.  (+info)

Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. (6/491)

Recirculatory pharmacokinetic models for indocyanine green (ICG), inulin, and antipyrine describe intravascular mixing and tissue distribution after i.v. administration. These models characterized physiologic marker disposition in four awake, splenectomized dogs while they were normovolemic, volume loaded (15% of estimated blood volume added as a starch solution), and mildly and moderately hypovolemic (15 and 30% of estimated blood volume removed). ICG-determined blood volumes increased 20% during volume loading and decreased 9 and 22% during mild and moderate hypovolemia. Dye (ICG) dilution cardiac output (CO) increased 31% during volume loading and decreased 27 and 38% during mild and moderate hypovolemia. ICG-defined central and fast peripheral intravascular circuits accommodated blood volume alterations and the fast peripheral circuit accommodated blood flow changes. Inulin-defined extracellular fluid volume contracted 14 and 21% during hypovolemia. Early inulin disposition changes reflected those of ICG. The ICG and inulin elimination clearances were unaffected by altered blood volume. Neither antipyrine-defined total body water volume nor antipyrine elimination clearance changed with altered blood volume. The fraction of CO not involved in drug distribution had a significant effect on the area under the antipyrine concentration-versus-time relationships (AUC) in the first minutes after drug administration. Hypovolemia increased the fraction of CO represented by nondistributive blood flow and increased the antipyrine AUC up to 60% because nondistributive blood flow did not change, despite decreased CO. Volume loading resulted in a smaller (less than 20%) antipyrine AUC decrease despite increased fast tissue distributive flow because nondistributive flow also increased with increased CO.  (+info)

Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective. (7/491)

BACKGROUND: Differences in the pharmacokinetics of the enantiomers of ketamine have been reported. The authors sought to determine whether these differences extend to pulmonary uptake and peripheral tissue distribution and to test the hypothesis that tissue distribution of the stereoisomers differs because of carrier-mediated drug transport. METHODS: The dispositions of markers of intravascular space and blood flow (indocyanine green, ICG) and total body water and tissue perfusion (antipyrine) were determined along with S-(+)- and R-(-)-ketamine in five mongrel dogs. The dogs were studied while anesthetized with 2.0% halothane. Marker and drug dispositions were described by recirculatory pharmacokinetic models based on frequent early and less-frequent later arterial blood samples. These models characterize pulmonary uptake and the distribution of cardiac output into parallel peripheral circuits. RESULTS: Plasma elimination clearance of the S-(+)-ketamine enantiomer, 29.9 ml x min(-1) x kg(-1), was higher than that of the R-(-)-enantiomer, 22.2 ml x min(-1) x kg(-1). The apparent pulmonary tissue volumes of the ketamine S-(+) and R-(-)-enantiomers (0.31 l) did not differ and was approximately twice that of antipyrine (0.16 l). The peripheral tissue distribution volumes and clearances and the total volume of distribution (2.1 l/kg) were the same for both stereoisomers when elimination clearances were modeled from the rapidly equilibrating peripheral compartment. CONCLUSIONS: Although the elimination clearance of S-(+)-ketamine is 35% greater than that of the R-(-)-enantiomer, there is no difference in the apparent pulmonary tissue volume or peripheral tissue distribution between the stereoisomers, suggesting that physicochemical properties of ketamine other than stereoisomerism determine its perfusion-limited tissue distribution.  (+info)

Evolution of microcirculatory disturbances after permanent middle cerebral artery occlusion in rats. (8/491)

Nonischemic brain capillaries show a continuous and heterogeneous plasma perfusion. In the current study, plasma perfusion was investigated in rats during 2 to 168 hours of permanent middle cerebral artery occlusion. Perfused capillaries were detected in brain cryosections by fluorescein isothiocyanate (FITC) dextran after 10 minutes of circulation time. Heterogeneity of capillary perfusion was identified by Evans blue (EB), which circulated for 3 seconds. In this setting, the heterogeneity of intracapillary EB concentrations reflects heterogeneities in capillary flow velocities. The CBF was quantified by simultaneous iodo[14C]antipyrine autoradiography. When moving from normal flow to low-flow areas in the ischemic hemisphere, three states of capillary filling could be distinguished: state 1--fast perfusion, filling by FITC dextran and EB (CBF 0.33 mL x g(-1) x min(-1)); state 2--delayed perfusion, only FITC dextran filling (CBF 0.104 mL x g(-1) x min(-1)); state 3--minimal perfusion, no dye filling (CBF 0.056 mL x g(-1) x min(-1)). In tissue of state 1 at the borderline to ischemic tissue, a higher heterogeneity of intracapillary EB concentration (85.7%) was found than in the contralateral nonischemic hemisphere (76.4%) (P < 0.05), indicating a compromised microcirculation. The adjacent ischemic areas were filled by FITC dextran (state 2) 2 to 4 hours after middle cerebral artery occlusion, indicating a maintained, although slow, perfusion at this time. Later, minimal perfused areas (state 3) progressively replaced the delayed perfused areas (state 2). This study shows, for the first time, the evolution of microvascular disturbances in relation to CBF. In the low-flow areas, an early residual plasma perfusion is later followed by a lack of perfusion or minimal perfusion. In areas of higher, although reduced flow at the border between normal and ischemic tissue, an extreme capillary perfusion heterogeneity indicates permanent microcirculatory abnormalities.  (+info)

*Antipyrine and benzocaine ear drops

"ANTIPYRINE WITH BENZOCAINE - OTIC". MedicineNet.com. "Auralgan (Antipyrine, Benzocaine, and Glygerin dehydrated) Drug ... Antipyrine 54 mg Benzocaine 14 mg Glycerin and Hydroxyquinoline Sulfate USP A/B otic drops are effective because antipyrine ... Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. It combines ... In 2008, Auralgan was reformulated to include acetic acid and U-polycosanol 410, in addition to antipyrine and benzocaine. Due ...

*Phenazone

... antipyrine Chisholm, Hugh, ed. (1911). "Antipyrine". Encyclopædia Britannica. 2 (11th ed.). Cambridge University Press. p. 134 ... Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. Possible ... Phenazone (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic, a nonsteroidal anti- ...

*Kairine

Fruitnight, J. Henry (1886). "Kairine and Antipyrine". Medical Record. 29 (23): 646-648. Bockmuhl M, Dorzbach E. Antipyretics ...

*John Collins (director)

Antipyrine, Fire Extinguisher. Collins's early work with ERS was presented at downtown New York City venues such as Nada, Here ... Antipyrine, Fire Extinguisher (Nada, 1991). Shuffle (New York Public Library, 2011), (Prague Quadrennial, 2011) A Sort of Joy ( ...

*Wavenumber

Murthy, V. L. R.; Lakshman, S. V. J. (1981). "Electronic absorption spectrum of cobalt antipyrine complex". Solid State ...

*Benzocaine

It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax. Benzocaine is indicated to ... "Antipyrine Benzocaine Otic - Side Effects, Dosage, Interactions". Everyday Health. 2015-03-18. Retrieved 2015-06-02. Lexicomp ...

*Wilhelm Filehne

Ueber das Antipyrin, ein neues Antipyreticum, 1884 - On antipyrine, a new antipyretic. Lehrbuch der Arzneimittellehre und ... Ueber das Pyramidon, ein Antipyrinderivat, 1896 - On Pyramidon, an antipyrine derivative. The Search for Anti-Inflammatory ...

*Dichloralphenazone

... is a 1:2 mixture of antipyrine with chloral hydrate. In combination with paracetamol and isometheptene, it ...

*Otitis media

Topical agents shown to be effective include antipyrine and benzocaine ear drops. Decongestants and antihistamines, either ...

*Metamizole

... made another derivative called pyramidon which was three times more active than antipyrine. In 1893, a derivative of antipyrine ... Yet later, chemists at Hoechst made a derivative, melubrine (sodium antipyrine aminomethanesulfonate), which was introduced in ... also called antipyrine, which has been called "the 'mother' of all modern antipyretic analgesics." Sales of that drug exploded ...

*Pyrazolone

... s are amongst the oldest synthetic pharmaceuticals, starting with the introduction of antipyrine (phenazone) in ...

*Ludwig Knorr

The synthesis in 1883 of the analgesic drug antipyrine, now called phenazone, was a commercial success. Antipyrine was the ... antipyrine, is not to be changed. (German: Antipyrin bleibt!). In 1885 Knorr married Elisabeth Piloty, the sister of his ...

*Triboluminescence

W. Clegg, G. Bourhill and I. Sage (April 2002). "Hexakis(antipyrine-O)terbium(III) triiodide at 160 K: confirmation of a ... antipyrine)terbium iodide. It is thought that these materials contain impurities, which confer properties of asymmetry to the ...

*Elaine Hamilton-O'Neal

ISBN 0-521-43415-7 "Sims Reed Rare Books, ''la deuxième aventure céleste de monsieur Antipyrine,'' by Tristan Tzara". Books. ...

*COX-3

... was actually discovered in 2002, and been found to be selectively inhibited by paracetamol, phenacetin, antipyrine, ...

*Primidone

... and the other enzyme-inducing anticonvulsants can cut the half-life of antipyrine roughly in half (6.2 ± 1.9 h vs. ...

*List of MeSH codes (D03)

... antipyrine MeSH D03.383.129.539.850.777 --- phenylbutazone MeSH D03.383.129.539.850.777.640 --- oxyphenbutazone MeSH D03.383. ...

*Bernard Fantus

Acetophenetidin Acetaminosalol Cocaine Heroin Aspirin Aconitine Anaesthesin Antimony potassium tartrate Antipyrine Apomorphine ...

*Antipyretic

... antipyrine), available in combination with benzocaine as an ear drop in the US. The U.S. Food and Drug Administration (FDA) ...

*Blood-brain barrier

The measurement of brain uptake of acetamide, antipyrine, benzyl alcohol, butanol, caffeine, cytosine, phenytoin, ethanol, ...

*Ethyl acetoacetate

... antipyrine and aminopyrine, and vitamin B1; as well as the manufacture of dyes, inks, lacquers, perfumes, plastics, and yellow ...

*Céline Arnauld

Antipyrine" (The First Heavenly Adventure of Mr. Antipyrine) by Tristan Tzara. Two months later, she is recorded as an author ...

*DMOZ - Health: Pharmacy: Drugs and Medications: A

February 1, 2017 at 11:15:03 UTC ...
Antipyrine biotransformation has been used extensively in clinical studies as a marker for general hepatic oxidative or cytochrome P450 (P450)-mediated, metabolism. Studies have indicated that more than one P450 is involved in the formation of the three major human metabolites, 4-hydroxyantipyrine, norantipyrine, and 3-hydroxymethylantipyrine. However, the specific P450s involved have not yet been determined. We have developed a sensitive method for the measurement of antipyrine metabolites formed in the in vitro incubations and applied it to determine the P450s participating in the formation of each metabolite in human liver microsomes. The identification of these P450s was accomplished through the use of simple and multivariate regression analysis, selective chemical inhibitors, and microsomes containing cDNA-expressed enzymes. These methods implicated P450s 1A2, 3A, and 2A6 in the formation of 4-hydroxyantipyrine. The predominant form involved in 3-hydroxymethylantipyrine formation was found ...
The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function Show moreThe following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function ...
Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. Forlaget udgiver titler inden for kunst, litteratur og teori; økonomi, teknologi, vandalisme, publicering som medium og praksis, skizofreni, science fiction og konceptuel poesi. Antipyrine er en åben situation, arbejder ofte kollektivt og researchbaseret, med et bagkatalog af komplekse og polemiske titler, der formulerer visioner i sin tid. Antipyrine organiserer seminarer, workshops og udstillinger, driver boghandel i Kunsthal Aarhus og udgiver tidsskriftet Monsieur Antipyrine, der redigeres af kunstner Jørgen Michaelsen, kunsthistoriker Mikkel Bolt og forfatterne Mikkel Thykier og Claus Handberg.. ...
antipyrine chemical properties, What are the chemical properties of antipyrine 60-80-0, What are the physical properties of antipyrine ect.
Rifampin is known to be an important stimulus to drug-metabolizing enzymes and can also induce the production of alpha 1-acid glycoprotein (AGP). We have studied the time course for induction of drug metabolizing capability as assessed by the clearance of antipyrine and the plasma concentration of AGP following a chronic course of rifampin in dogs. The kinetics of the induction process were observed during a 22-day treatment period, and the wash-out period kinetics were followed for another 3 weeks. Rifampin kinetics were measured at the end of the 22-day dosing period. Both antipyrine clearance and AGP concentration were significantly increased by the rifampin treatment; antipyrine clearance doubled and AGP concentrations nearly tripled. When analyzed by a newly developed kinetic model of induction, it was determined that the time course for AGP or antipyrine clearance was not governed by a single rate constant. The second rate constant did not represent the accumulation or persistence of ...
Here, we have demonstrated the potential of meso- and microporous carbons in controlled release applications and targeted oral drug delivery. We have employed two mesoporous and two microporous carbons for the sustained release of one water-soluble drug (antipyrine) and one water-insoluble drug (indomethacin), using these as models to examine the controlled release characteristics. The micro-/mesoporous carbons were characterized as having a BET surface area of 372-2251 m 2 g -1 and pore volume 0.63-1.03 cm 3 g -1. The toxicity studies with E. coli bacterial cells did not reveal significant toxicity, which is in accordance with our previous studies on human cells with similar materials. Mucin adsorption tests with type III pork mucin demonstrated 20-30% mucin adsorption by the carbon samples and higher mucin adsorption could be attributed to higher surface area and more oxygen functionalities. Antipyrine and indomethacin loading was 6-78% in these micro-/mesoporous carbons. The signatures in ...
Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. Forlaget udgiver titler inden for kunst, litteratur og teori; økonomi, teknologi,
AOAC Official Method AOAC 968.42-1969, Benzocaine and antipyrine in drugs. Spectropho - The files are in electronic format(PDF/DOC/DOCX) and will be sent to your email within 24 hours. Test Method:AOAC 968.42-1969Title:Benzocaine and antipyrine in drugs. Spectrophotometric methodPages:2
Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. Forlaget udgiver titler inden for kunst, litteratur og teori; økonomi, teknologi,
What should I discuss with my healthcare provider before taking acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA)? How should I take acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA)?
Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Otozin (Antipyrine / Benzocaine / Zinc)
Learn about Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
569-84-6 - DXKXOTURGHVQIW-UHFFFAOYSA-N - Antipyrine mixture with aspirin - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Antipyrine definition: a drug formerly used to reduce pain and fever . Formula: C 11 H 12 N 2 O | Meaning, pronunciation, translations and examples
Listing your company for AICA ANTIPYRINE allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
Find medical information for ISOMETHEPTENE/ ACETAMINOPHEN/ DICHLORALPHENAZONE - ORAL (a-SEET-a-MIN-oh-fen/EYE-soe-meth-EP-teen/ DYE-klor-al-FEN-a-zone
Isolated rat livers were perfused via the portal vein with a blood-Ringer mixture containing a constant inflow concentration of D2O and, in some cases, antipyrine. The rate of increase of outflow concentration was studied, comparisons being made between D2O, antipyrine and a theoretical outflow curve based on completely flow-limited distribution. The effect of flow rate on the deviation of D2O from theoretical was also studied. The results indicate that exchange of D2O and antipyrine between blood and tissue in the perfused rat liver is extremely rapid relative to the rate of blood supply of these substances to the organ, even at flows several times that occurring in vivo. In the average experiment the average D2O concentration in the liver during the early period of the perfusion was about 90% of the mixed venous concentration. The factors responsible for the failure of D2O to distribute maximally, particularly tissue perfusion heterogeneity and diffusion limitation, are discussed. Although ...
Additional experiments were conducted to examine the disappearance and appearance coefficients of the passive transcellular (antipyrine, 0.2 mM) and paracellular (mannitol, 2.0 mM) markers using the above-mentioned SPIP model (n = 5/group). The gut does not metabolize mannitol and antipyrine and absorbs these two compounds in an unchanged form. The effects of verapamil at 50 μM on the permeability of both antipyrine and mannitol were also investigated.. Cell Culture. Caco-2 cells were obtained from the American Type Culture Collection (Rockville, MD). The control vector MDCKII cell line and its human MDR1 recombinantly transfected derivative, MDR1-MDCKII, were a kind gift from Professor Piet Borst (Netherlands Cancer Institute, Amsterdam, The Netherlands). The cells were cultured in Dulbeccos modified Eagles medium supplemented with 10% fetal bovine serum, 1% nonessential amino acids, and 100 U/ml penicillin and gentamicin. The cells were grown in an atmosphere of 5% CO2 and 90% relative ...
Antipyrine Bookstore i Kunsthal Aarhus er et nyt samarbejde med det uafhængige forlag Antipyrine. Samarbejdet begyndte i sommeren 2013 med produktionen af en række publikationer, udstillinger, forskning og udstilingen Reading Machines. Boghandlen udvikles gradvist og fyldes med en lang række udgivelser særligt fra små uafhængige forlag og tidsskrifter fra hele verden, indenfor de overordnede emner kunst, litteratur og teori. Herudover vil boghandlen give særlig plads til den tekstbaserede kunst og kunstnerbøger.. Boghandlen vil være en del af Kunsthal Aarhus øvrige program og i varierende omfang reflektere og tilbyde yderligere kontekst til aktuelle udstillinger med særligt udvalgte udgivelser og arrangementer. Herudover vil boghandlen have et eget program med gæsteforlag, små udstillinger af bøger og en række foredrag og boglanceringer i samarbejde med de repræsenterede forlag,tidsskrifter og andre aktører.. Antipyrine Bookstore har omkring 60 små og store udgivere i ...
4-Iodoantipyrine was prepared from antipyrine according to the reaction equation:. 3C11H12N2O+2KI+KIO3+3HCl→3C11H11N2OI+3KCl+3H2O. The product was separated from the reaction mixture and purified by recrystallization. The iodoantipyrine was labeled with I131 by means of an exchange reaction with NaI131. It was separated from the unbound radioactivity by anion exchange chromatography.. The purity of the product was determined by cellulose thin layer chromatography using ethanol-chloroform-water (45:45:10) as the solvent system. The purity of the 4-iodoantipyrine-I131 decreased with time due to a splitting off of the I131 atom and subsequent formation of NaI131. This spontaneous deiodination was best minimized by storage in methanol at low temperatures.. ...
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children. Older adults Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly ...
Edaravone has been used in patients with acute ischemic stroke in Japan for over 10 years but does not have marketing authorization in Europe or America. Either patients in Europe and America are not receiving an effective treatment, or those in Asia are being given a treatment which is not effective. Finding out which of these is true will require further clinical trials, and a better understanding of its efficacy in animal models may help inform the design of those trials so that it might be tested under conditions where there is the greatest prospect of success. We systematically reviewed the efficacy of edaravone in animal models of focal ischemia and summarized data using weighted mean difference DerSimonian and Laird random-effects modeling. We used stratified meta-analysis and metaregression to assess the influence of study design and methodological quality. We identified 49 experiments describing outcome in 814 animals; 30 experiments (519 animals) reported functional and 35 experiments ...
Edaravone may be the first ALS treatment approved in U.S. in more than 20 years. As many as 30,000 Americans are estimated to be affected by ALS and more than 5,600 are diagnosed annually.
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For further analysis of mechanisms, a dose of 3 mg/kg edaravone was used, because maximum effects of improvement of survival rates were observed at this dose.. Serum Alanine Aminotransferase (ALT) Levels after LPS Administration. In a separate set of experiments to determine the extent of liver damage by LPS and evaluate effects of edaravone on liver injury, ALT assay was performed. Blood samples were collected from the aorta 9 h after LPS administration in all groups and centrifuged at 1,200g for 10 min at 4°C, respectively (n = 8 in each group). Serum was stored at -80°C until assays. ALT was measured enzymatically (Nissui Transnase; Nissui Pharmaceutical Co., Tokyo, Japan) (Arai, 1986).. Pathological Change and the Number of Neutrophils in the Liver. Liver specimens taken 9 h LPS administration were formalin-fixed, embedded in paraffin, and stained with hematoxylin-eosin to assess inflammation and necrosis (n = 6 in each group). Histological samples were evaluated by one of the authors and ...
Benzocaine is a local anesthetic thats used on its own and in combination with other medications. When combined with antipyrine...
The first Phase 3 clinical trial of edaravone was conducted in 205 patients randomized to receive edaravone (n=101) or placebo (n=104) (Abe et al., 2014). Treatment consisted of i.v. infusions given over 60 min for the first 14 days of cycle 1 (followed by 14 days off drug), and then 10 of the first 14 days during cycles two through six, with 14 days off drug following treatment in each cycle. The primary endpoint was the change in ALSFRS-R during the 24-week treatment period. Results showed that the change in ALSFRS-R scores were -5.70 and -6.35 in the edaravone and placebo groups, respectively, which did not represent a statistically significant different (P=0.411). No serious adverse events were reported and the level and frequency of adverse events were similar between the two treatment groups. A post-hoc analysis suggested that edaravone could be efficacious in a restricted subgroup that includes recently diagnosed patients with milder disease symptoms ...
Learn about the potential side effects of Amidrine (acetaminophen/dichloralphenazone/isometheptene mucate). Includes common and rare side effects information for consumers and healthcare professionals.
In keeping with the Colleges mandate to serve and protect the public interest, we recognize the importance of ensuring that patients have safe access to new drug therapies, especially when there are limited treatment options available.
1. Administration of dichloralphenazone, a complex of chloral hydrate and phenazone (antipyrine) caused a fall in steady-state plasma warfarin concentration and loss of anticoagulant control in five subjects.. 2. This effect of dichloralphenazone is due to stimulation of the drug-oxidizing enzymes of the liver endoplasmic reticulum by antipyrine, the non-hypnotic part of the complex. Administration of antipyrine caused a fall in steady-state plasma warfarin concentration in five subjects, a shortening of the plasma warfarin half-life, with increased urinary excretion of the metabolites of 14C-labelled warfarin in two subjects and increased urinary excretion of 6β-hydroxycortisol which is formed in the liver endoplasmic reticulum.. 3. Administration of chloral hydrate, the hypnotic part of dichloralphenazone, caused no change in anticoagulant control but a fall in steady-state plasma warfarin concentration in five subjects. This is due to the accumulation of trichloroacetic acid which displaces ...
Diminazene and antipyrine granules,US $ 1.4 - 2 / Box, Antibacterial Drugs, Injection, Granules, Cattle, Fowl, Horse, Sheep.Source from Hebei Kexing Pharmaceutical Co., Ltd. on Alibaba.com.
A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a newly synthesized free radical scavenger used commonly for the treatment of adult acute cerebral infarction. A recent clinical study suggests that it may theoretically be used in treatment of neonatal hypoxic-ischemic (HI) encephalopathy.1 The fetal-neonate transition involves physiological hyperoxygenation and increased free radical formation.1 The fetus and neonate have less ability in scavenging free radicals and exerting antioxidant effects;1 and, lastly, neonatal HI encephalopathy extends beyond the brain to multiple organs, where free radicals play an important role in developing tissue damage.1 We have reported that edaravone has a neurorescue effect on neonatal rats in a dose-dependent manner after HI.2 Edaravone (9 mg/kg) significantly decreased the infarct areas compared with the controls after HI.2 Edaravone (6 mg/kg) showed a significant reduction of infarct areas on 1 day, but not on 7 days after HI, which suggests that multiple ...
Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. Effect of lipopolysaccharide on uterine contractions and prostaglandin production in pregnant rats
Background: Free radicals cause myonephropathic metabolic syndrome (MNMS), which damages not only muscles but also kidneys. At ATVB 2014, we previously reported edaravone (Radicut®, Mitsubishi Tanabe Pharma Co., Japan), the free radical scavenger may suppress kidney damage induced by MNMS.. Objective: In this study, we evaluated whether edaravone suppresses MNMS-induced kidney damage, focusing on active neutrophils and tubular function.. Methods: Either 3.0 mg/kg of edaravone (edaravone group; n = 4), or saline (MNMS group; n = 6) was intraperitoneally injected into male Lewis male rats (508 ± 31 g). MNMS models were induced, by clamping the bilateral common femoral arteries for 5 hours, followed by de-clamping after more 5 hours. The both kidneys were stained with naphthol AS-D chloroacetate esterase to detect active neutrophils and with Periodic Acid Schiff (PAS) to assess glycogen storage. Normal kidneys were also stained as control (n = 3). Kidney damage was evaluated by counting the ...
The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male Sprague-Dawley-rats were administered 5.1 millimoles per kilogram (mmol/kg) diglyme or 0.1 percent phenobarbital (PB) in their drinking water for 22 days. The effects on hexobarbital sleeping time were evaluated. Other rats were pretreated with 5.1mmol/kg labeled diglyme or 0.
Other names: Acetamide, N-antipyrinyl-; Acetamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-; Acetamidoantipyrine; Acetyl-4-aminoantipyrine; Acetylaminoantipyrine; Acetylated 4-aminoantipyrine; Antipyrine, 4-acetamido-; N-Acetyl-4-aminoantipyrine; 4-Acetamidoantipyrine; 4-Acetaminoantipyrine; 4-Acetoaminoantipyrine; 4-Acetylaminophenazone; Aminoantipyrine, N-acetyl-; 4-(N-Acetylamino)antipyrine; NSC 331807; N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)acetamide ...
Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles Danbo Yang1, Sang Van2, Xinguo Jiang3, Lei Yu1,21Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China; 2Biomedical Group, Nitto Denko Technical Corporation, Oceanside, CA, USA; 3School of Pharmacy, Fudan University, Shanghai, People's Republic of ChinaAbstract: The purpose of this study was to develop a novel formulation of paclitaxel (PTX) that would improve its therapeutic index. Here, we combined a concept of polymer–PTX drug conjugate with a concept of polymeric micelle drug delivery to form novel free PTX-loaded poly(L-γ-glutamylglutamine) (PGG)–PTX conjugate nanoparticles. The significance of this drug formulation emphasizes the simplicity, novelty, and flexibility of the method of forming nanoparticles that contain free PTX and conjugated PTX in the same drug
1-(4-Sulfophenyl)-3-carboxy-5-pyrazolone 118-47-8 MSDS report, 1-(4-Sulfophenyl)-3-carboxy-5-pyrazolone MSDS safety technical specifications search, 1-(4-Sulfophenyl)-3-carboxy-5-pyrazolone safety information specifications ect.
Since episodes of AOM frequently are associated with pain, the use of analgesics-especially during the first 24 hours of an episode-are strongly recommended by the AAP/AAFP guidelines. Treatment options to reduce the pain associated with otalgia include acetaminophen, ibuprofen, and antipyrine/benzocaine otic solution.7 Antipyrine/benzocaine otic solution is a prescription product used for its local analgesic properties. After the solution is instilled into the ear canal, relief of ear pain occurs in approximately 30 minutes. This product is for otic use only, and it should not be used if the solution is brown or contains a precipitate. Disposal of the bottle is recommended 6 months after the dropper is placed in the solution.12. Treatment with an antibacterial agent is recommended for children younger than 6 months of age, children aged 6 months to 2 years with a certain diagnosis of AOM, and any child with moderate-to-severe otalgia or a fever of 102.2°F (39°C) or greater. Observation ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. ...
This medicine is for use in the outer ear canal. Follow the directions on the prescription label. Wash hands before and after use. Warm the solution by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. Insert a cotton pledget moistened with medication at the ear opening. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use. Use your medicine at regular intervals. Do not use it more often than directed.. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.. ...
Ear pain. This is a topical anesthetic used to relieve ear pain in ear infections. Drops are put in the ear canal and a cotton plug is then inserted to keep the medication from dribbling out. It can be used every few hours if needed. Read more... ...
samu SULPYRIN injection, an analgesicㆍantipyreticㆍantispasmodic of which main ingredient is Sulpyrin, one of Pyrazolone derivative, shows stronger fever alleviating effect about three times as much as Antipyrine and also has powerful action of analgesic and antiphlogistic ...
Abstract Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in cl..
A list of 10 letter words that end with ne in the enable censored word list. (147 words: adamantine adrenaline adulterine amantadine anglophone anopheline anthracene antipyrine aquamarine asparagine autoimmune aventurine barkentine benzocaine birthstone bloodstone borderline branchline breastbone brigandine...)
RADICAVA (Edaravone) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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pyrazolone nankin spiritful rectoress misexpression burgher sharecrop pomade decurve solemnify unkenneled overobsequiousness loafingly carriageless [email protected] ...
The FDA approved Radicava (edaravone) to treat patients with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrigs disease.
Applications of Rauzy Induction on the Generic Ergodic Theory of Exchange Transformations. Financial Analyst, TPR Associates, The Woodlands, TX.. 2005: Zheng Meng B.S., M.S. Shanghai University ...
Product Name: Veterinary Diminazene Aceturate Antipyrine injection Common Name: Veterinary Diminazene Aceturate Phenazone injection Strength: Diminazene Aceturate 140 mg Antipyrine 750 mg Description: Diminazene Aceturate + Antipyrine ready to use...
As a part of a directed program for development of new active agents, novel heterocyclic derivatives with antipyrine and pyrazolone moieties -incorporated in- have been designed and synthesized. Starting with 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivative 2a,b novel Mannich bases derivatives have been synthesized and biologically evaluated for their anti-inflammatory activity. Furthermore, the activity of such compounds has been tested interestingly as COX-1 and COX-2 inhibitors. Structure elucidation of the synthesized compounds was attained by the use of elemental analysis, IR, 1H NMR, 13C NMR, and Mass spectrometry techniques. Compounds 3b, 3d and 4b represent the high % inhibition values for both COX-1 and COX-2. On the other hand, compound 8 showed little selectivity against COX-2 while compound 10 showed good selectivity against COX-1 only. Structure activity relationship has been discussed and the results were confirmed by molecular docking calculations. ...
Purpose.: To investigate whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, would be neuroprotective against photoreceptor cell death in a rat model of retinal detachment (RD). Methods.: RD was induced in adult Brown Norway rats by subretinal injection of sodium hyaluronate. Edaravone (3, 5, or 10 mg/kg) or physiologic saline was administered intraperitoneally once a day until death on day 3 or 5. Oxidative stress in the retina was assessed by 4-hydroxynonenal staining or ELISA for protein carbonyl content. Photoreceptor death was assessed by TUNEL and measurement of the outer nuclear layer thickness. Western blot analysis and caspase activity assays were performed. Inflammatory cytokine secretion and inflammatory cell infiltration were evaluated by ELISA and immunostaining, respectively. Results.: RD resulted in increased generation of ROS. Treatment with 5 mg/kg edaravone significantly reduced the ROS level, along with a decrease in TUNEL-positive cells in the ...
The aim of this study was to develop a pharmacokinetic model to describe the transplacental transfer of drugs, based on the human placental perfusion study. The maternal and fetal sides of human placentas were perfused with salicylic acid together with antipyrine, a passive diffusion marker. The drug concentration in the placental tissue was determined at the end of perfusion. A compartment model consisting of maternal space, fetal intravascular space, and placental tissue was fitted to the observed concentration profiles of salicylic acid in the maternal and fetal effluents. The developed model could adequately explain the concentration profiles of salicylic acid in the effluents with influx clearances from maternal and fetal perfusates to placental tissue of 0.0407 and 0.0813 ml/min/g cotyledon and efflux rate constants from placental tissue to maternal and fetal perfusates (k2 and k3) of 0.0238 and 0.176 min(-1), respectively. The kinetics of antipyrine was adequately described by assuming rapid
This medicine is only for use in the outer ear canal. Do not take by mouth. Follow the directions carefully. Wash hands before and after use. The solution may be warmed by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. After the drops are instilled, remain lying with the affected ear upward for 5 minutes to help the drops stay in the ear canal. A cotton pledget moistened with medicine may be gently inserted at the ear opening for no longer than 5 to 10 minutes to ensure retention. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use.. If using for ear wax removal, your doctor or health care professional will tell you how to use this medicine.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
This medicine is only for use in the outer ear canal. Do not take by mouth. Follow the directions carefully. Wash hands before and after use. The solution may be warmed by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. After the drops are instilled, remain lying with the affected ear upward for 5 minutes to help the drops stay in the ear canal. A cotton pledget moistened with medicine may be gently inserted at the ear opening for no longer than 5 to 10 minutes to ensure retention. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use.. If using for ear wax removal, your doctor or health care professional will tell you how to use this medicine.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
Aalbersberg, William G.L. (2009) Fiji field projects. [Professional and Technical Reports]. Agarwal, Ram K. and Modi, H.R. and Prasad, Surendra (2009) Synthesis, spectral and thermal properties of some novel coordination compounds of VO(IV) derived from 4[n-(4¢-ethylbenzalidene)amino]antipyrine thiosemicarbazone and 4[n- (2¢,4¢-dimethyl benzalidene) amino]antipyrine thiosemicarbazone. Journal of the Iranian Chemical Research, 2 (3). pp. 173-182. ISSN 2008-1030. Ahmad, Nesar and Khan, Mohammad G.M. and Quadri, S.M.K. and Kumar, M. (2009) Modelling and analysis of software reliability with burr type x testing-effort and release-time determination. Journal of Modelling in Management, 4 (1). pp. 28-54. ISSN 1746-5664. Ahsan, M.J. and Nujmussehar, and Khan, Mohammad G.M. (2009) Mixed allocation for fixed precision. Pure and Applied Mathematika Sciences, 69 (1-2). pp. 93-103. ISSN 0379-3168. Amosa, Desmond U. and Narayan, Jashwini J. and Naz, Rafia and Pandaram, Atishwar (2009) Fixing Fijis civil ...
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
A silver halide color photographic material containing at least one silver halide emulsion and at least one kind of 5-pyrazolone couplers having the releasable group shown by following formula (I) at
Hey mommas- I woke up last night with extreme ear pain and what turned out to be a horrible ear infection and possibly ruptured ear drum. I was prescribed augmentin which seems to be deemed safe for breastfeeding moms. I was also given drops to help with pain and drainage called antipyrine benzocaine. I couldnt find much on it other than the usual cya warning to talk to your doc if pregnant or breastfeeding. Anyone use these/know their safety??
53-35-0 - GNFTWPCIRXSCQF-UJXAPRPESA-N - 6beta-Hydroxycortisol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
GlycoPOD (GlycoScience Protocol Online Database) is part of the program of the Japan Consortium for Glycobiology and Glycotechnology Data Base(JCGGDB). More than 100 experts have been involved in and contributed more than 150 protocols.
Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity by antipyrine clearance, before and after cimetidine. There was no reduction in indocyanine green clearance but antipyrine clearance, as expected, was significantly reduced by 15% at four weeks. Chronic cimetidine treatment does not reduce apparent liver blood flow and is therefore unlikely to be of use in the treatment of portal hypertension. The cimetidine associated hepatic enzyme inhibition appears to persist with prolonged treatment. Therefore patients on chronic cimetidine remain vulnerable to certain drug interactions.. ...
Abstract Several parameters related to mono-oxygenase activity were followed in a population of chemical workers and controls. Workers exposed to toluene and xylene had a significant increase of urinary glucaric acid, that was correlated with hippuric acid excretion. On the other hand, workers exposed to pigments showed a marked increase of antipyrine half-life. A dose-related decrease of liver N-demethylase was induced in rats by the administration of a mixture of three of the pigments in use in the plant. Serum gamma-glutamyltranspeptidase was decreased in the workers exposed to pigments, but this variation was not statistically significant. The exposure to different chemicals in the workplace seemed to induce a complicated variation of mono-oxygenase levels, some enzyme being inhibited and others induced in the same group of workers. The sensitivity of these workers to toxic effects of chemicals, carcinogenic compounds and drugs seems to differ markedly from the control population. © 1982 ...
The phase II open label trial suggested that edaravone is safe and effective in ALS, markedly reducing 3-nitrotyrosine levels in the cerebrospinal fluid. One of the two randomized controlled trials showed beneficial effects in ALSFRS-R, although the differences were not significant.. The last trial demonstrated that edaravone provided significant efficacy in ALSFRS-R scores over 24 weeks where concomitant use of riluzole was permitted. Eligibility was restricted to patients with a relatively short disease duration and preserved vital capacity. Therefore, combination therapy with edaravone and riluzole should be considered earlier.. You may also check. Writing Group.; Edaravone (MCI-186) ALS 19 Study Group. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2017; 16:505-512.. ...
With the hybrid positron emission tomography (PET) and computed tomography (CT) systems, coronary artery anatomy and physiology can be realized during the same imaging session. Whereas the coronary CT angiography provides information on the presence and extent of the luminal stenosis in coronary artery disease (CAD), PET blood flow tracers provide information on the downstream functional consequence of these lesions. Current clinical applications of these imaging studies are focused predominantly on the identification of coronary artery lesions, which can be treated by coronary interventions. With the evolving technology, CT angiography may allow interrogation of the plaque morphology beyond the assessment of the luminal stenosis and the new radio-labeled ligands may expand the application of PET to assess plaque biology and instability. This is particularly relevant in asymptomatic subjects with coronary risk factors in whom the diagnosis often remains elusive before the actual occurrence of an ...
Semantic Scholar extracted view of Local cerebral blood flow and oxygen tension at different stages of surgical intervention in patients with meningiomas of the superior sagittal sinus by Semeniutin Vb et al.
019376 MAURYA R C, SUTRADHAR D, SAHU S, BOHRE P ( Coordination and Bioinorganic Chemistry Laboratory, Chemistry Div, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Lakshmangarh-332 311, E-Mail : [email protected]) : Synthesis, characterization and 3d molecular modeling of some new 8-coordinate cis- dioxomolybdenum VI) chelates involving (O,N,O)-donor coordination matrix of schiff bases derived from 4-amino2,3-dimethyl-1-phenyl-2-pyrazolin-5-one and some β-diketoenolates. Rasayan J Chem 2008, 1(2), 395-412 ...
Selected References. Lyon, M.J. and R.N. Payman (2000) Comparison of the vascular innervation of the rat cochlea and vestibular system. Hearing Res. 141:189-198.. Lyon, M.J. (2000) Nonadrenergic innervation of the rat laryngeal vascular supply. Anat. Rec. 259:180-188.. Lyon, M.J. and R.C. Jensen (2001) Quantitative Analysis of Rat Inner Ear Blood Flow Using the Iodo[14C]antipyrine Technique. Hearing Res. 153:164-173.. Lyon, M.J. and J.R. Davis (2002) Age-related Blood Flow and Capillary Changes in the Rat Utricular Macula: A Quantitative Stereological and Microsphere Study. JARO 3:167-173.. Lyon, M.J. and J. Barkmeier-Kraemer (2004) Chapter 4: Vascular Supply of the Larynx; 69-108. In: Vocal Rehabilitation in Medical Speech-Language Pathology. Eds: Sapienza, C. and Casper, J. Publisher: Pro-Ed Inc, Austin TX.. Lyon, M.J., L.Steer, and L.T. Malmgren (2007) Stereological Estimates Indicate That Aging Does Not Alter the Capillary Length Density in the Human Posterior Cricoarytenoid Muscle. J Appl ...
ABSTRACT: Protein citrullination originates from enzymatic deimination of amino acid arginine in a protein and is involved in various biological processes during health and disease. However, it has not been investigated in heart. Therefore, our goal was to identify novel substrates for peptidylarginine deiminase (PAD), enzyme responsible for this modification and associate it with changes in protein citrullination during heart failure (HF).. METHODS: Proteomics methods were used to identify citrullinated proteins and the site of modification in control mouse and control vs. HF human heart tissue (5 per group). The characterization of deiminated proteins was facilitated by modification of peptide-bound citrullineted Arg residues with antipyrine and butanedione, allowing for the unambiguous identification by mass spectrometry. Verification of citrullinated proteins was carried out by 2DE (modification causes pI shift) and western blot with anti-citrullinated antibody. PAD enzyme expression was ...
Although it is now well documented (6, 8) that pial as well as intracerebral vessels are amply supplied with sympathetic adrenergic nerves which, as shown for pial arteries, fulfill ultra-structural...
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The anti-allergy drug FPL 52757 (Fisons Ltd. ,) 6,8-diethyl-5-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid produced mild and reversible hepatotoxicity in some patients during clinical trials. The purpose of this work was to elucidate the mechanism by which FPL 52757 caused hepato-toxicity. However, since further humans could not be tested the work is limited to animal models. Toxicity studies showed that the beagle dog was the only animal species of ten tested which was readily susceptible to the hepatotoxic effect of the compound. In this project hepatotoxicity could not be demonstrated in ferrets or rats in special studies designed to reduce resistance to drug-induced hepatotoxicity. Similarly, hepatic microsomal enzyme induction in dogs by pretreatment with phenobarbitone and protection against cytotoxicity by pretreatment with methionine provided no evidence for involvement of a reactive metabolite in the hepatoxicity. Work by Fisons and additional studies in this project showed that the ...
The drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a potent scavenger of oxygen free radicals and also functions as a modulator of transcription factors, repressing NFκB and activating Nrf2, to regulate oxidative stress. EDA displays complementary anti-oxidative and anti-inflammatory effects. The injectable small molecule is currently investigated for the treatment of several non-neurological diseases. The potential interest of EDA in oncology is reviewed here. EDA is a mild antiproliferative agent but has been found to enhance significantly the anticancer and antimetastatic activities of irinotecan in a colon cancer model. Anticancer derivatives of EDA have been designed but they generally display a limited antiproliferative activity. The antioxidant and anti-inflammatory activity of EDA can be best exploited to protect non-tumor cells from damages induced by ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Literature References: Naturally occurring dipeptide found in large amounts in skeletal muscle. Also present in other tissues such as brain, cardiac muscle, kidney. Water soluble antioxidant; functions as a free-radical scavenger. Isoln: Gulewitsch, Amiradzibi, Ber. 33, 1902 (1900); Wolff, Wilson, J. Biol. Chem. 95, 495 (1932); 109, 565 (1935). Synthesis from histidine and b-iodo- or b-nitropropionyl chloride: Baumann, Ingvaldsen, ibid. 35, 271 (1918); Barger, Tutin, Biochem. J. 12, 406 (1918). Later syntheses: Sifford, du Vigneaud, J. Biol. Chem. 108, 753 (1935); R. A. Turner, J. Am. Chem. Soc. 75, 2388 (1953); F. J. Vinick, S. Jung, J. Org. Chem. 48, 392 (1983). Crystal structure: H. Itoh et al., Acta Crystallogr. 33B, 2959 (1977). Possible role in wound healing: D. E. Fischer et al., Proc. Soc. Exp. Biol. Med. 158, 402 (1978). Review of physiological properties and therapeutic potential: S. E. Gariballa, A. J. Sinclair, Age Ageing 29, 207-210 (2000). ...
chemBlink provides information about CAS # 1419478-52-6, D-Glucaric acid 2,3,4,5-tetrakis[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate], molecular formula: C42H34O20.
In this section, we take a detailed and comprehensive look at drug clearance - an enormously important concept in the field of drug development.
The changes in the permeability properties of the rete capillaries of the eel in response to temperature shifts were studied during countercurrent perfusion at constant flow and pressure. Tracers and oxygen were added to the arterial perfusate. From the ratio of end concentrations of arterial to venous capillaries divided by surface area, calculated from rete weight, a value for the ratio of permeability to flow, P/F, with dimensions in centimeters-2 was estimated. Because flow and surface area are constant, this provides an index of how permeability varies with time. A group of paracellular (albumin, sucrose, and sodium) and cellular (antipyrine, water, and oxygen) probes were used. When the temperature of the perfusate was raised abruptly from 25 degrees C to 35 degrees C, P/F values rose continuously and irreversibly from 0.042 +/- 0.009 to 0.281 +/- 0.112 cm-2 (mean +/- SEM) for 125I-albumin, from 0.082 +/- 0.006 to 1.74 +/- 0.070 cm-2 for [14C]sucrose, and from 0.32 +/- 0.06 to 2.78 +/- ...
Following up on our June 2016 blog post about edaravone, an intravenous drug therapy produced by Mitsubishi Tanabe Pharma Corporation, locally based in Jersey City, N.J., with a head office in Osaka, Japan, there has been recent news as to the status of the drug in the U.S. At the end of August 2016, the…
TY - JOUR. T1 - Mortality in Acute Cerebral Infarction in Young Adults-A Ten-Year Experience. AU - Biller, José. AU - Adams, Harold P.. AU - Bruno, Askiel. AU - Love, Betsy B.. AU - Marsh, E. Eugene. PY - 1991/1/1. Y1 - 1991/1/1. N2 - We reviewed the one-month mortality among 213 patients aged fifteen to forty-five years (mean thirty-five) with acute cerebral infarction (CI) evaluated during the period July 1, 1977, to February 1, 1988. Atherosclerotic cerebral infarction (ACI) was diagnosed in 59 (27.7%) patients, 53 (24.9%) had non- atherosclerotic vasculopathies (NAV); 46 (21.6%) had cardioembolic infarcts (CEI). Hematologically related disorders were diagnosed in 30 (14.1%) patients; the cause of CI could not be established in 25 (11.7%) patients. Fourteen patients (9 men, 5 women, mean age 34.8 years), (6.6%) died within thirty days of their CI: 7 had CEI (7/46, 15.2%); 4 had ACI (4/59, 6.7%); and 3 had NAV (3/53, 5.6%). Our data suggest that young patients with acute CI have a thirty-day ...
Synopsis: Oral delivery is the preferred route of drug administration. An orally administered drug is firstly subjected to metabolism by the enterocytes in the intestinal mucosa and the intestinal microbiome in the intestinal lumen, followed by metabolism by the hepatocytes in the liver upon absorption into the portal circulation. Accurate assessment of in vivo drug properties therefore will require a clear understanding of the combined roles of enteric and hepatic drug metabolism. In vitro and in vivo experimental approaches that are well-established for the elucidation of the roles of hepatic drug metabolism on drug disposition, drug-drug interactions, and drug toxicity, should therefore be applied towards enteric drug metabolism. The presentations in this Inaugural HERO workshop serve to communicate the latest findings in experimental approaches to evaluate enteric drug metabolism, and the application of enteric data in concert with hepatic data in the assessment of in vivo drug properties. ...
Rats of either sex as intact or partially hepatectomized (two-thirds liver removal) were injected s.c. daily for 7 days post-operatively with natural and synthetic estrogens, androgens or anabolic steroids, progesterone and adrenal cortical hormones
Lu, A.Y.H., Kuntzman, S.W., Jacobson, M. and Conney, A.H. (1972). "Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations". J. Biol. Chem. 247: 1727-1734. PMID 4401153. ...
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... are substances found in food that prevent and slow oxidative damage from dangerous free-radicals. Free-radicals are by-products of our cells use of Oxygen, and can cause damage to our bodies. Antioxidants are also known as free-radical scavengers, preventing and repairing oxidative damage. Supplementing your diet with antioxidants is extremely vital. Certain complications have been shown to be associated with oxidative damage, such as diabetes, cancer, heart disease, and macular degeneration.
... are substances found in food that prevent and slow oxidative damage from dangerous free-radicals. Free-radicals are by-products of our cells use of Oxygen, and can cause damage to our bodies. Antioxidants are also known as free-radical scavengers, preventing and repairing oxidative damage. Supplementing your diet with antioxidants is extremely vital. Certain complications have been shown to be associated with oxidative damage, such as diabetes, cancer, heart disease, and macular degeneration.
Rita Elkins discusses how this amazing free-radical scavenger has gained impressive credentials from the results of various studies and its use in Europe and elsewhere.
MCI-186, CAS: 89-25-8, is A free radical scavenger that enhances NGF protein levels via the JNK pathway. MF: C10H10N2O, MW: 174.20. Cited in 7 publications
Dipyrone contains active substance called metamizole (analgesic from the pyrazolone group). It depressess central nervous system and causes a pain relief.
Research Topics, Species, Scientific Experts, Genomes and Genes, Publications, Locale about Experts and Doctors on enzyme induction in Finland
Coenzyme Q10, or CoQ10, is a free radical scavenger found in the powerhouse of your cells, the mitochondria, and is one of your bodys most important and major energy sources. It plays a major role in energy production, and also supports neurological and cardiovascular health. However, it naturally decreases both as you age, and when your body has a weakened immune system.. This product is great for you if you:. ...
DRUG METABOLISM & DISPOSITION (UK) i Tidningsarkivet. Ett digitalt arkiv för svenska tidningar och tidskrifter. Här finns bland annat omslag och innehållstexter för DRUG METABOLISM & DISPOSITION (UK).
Four major, interdependent mechanisms are involved in the control of cerebral blood flow: metabolic coupling: neural control, involving both extrinsic and intrinsic neural pathways: Pco2 and autoregulation. Although this division may be somewhat artificial and these control mechanisms probably operate in concert, it is useful to consider each separately. Metabolic Control Local cerebral blood flow (CBF) is regionally heterogeneous. The varied pattern of CBF is neither random nor related to the anatomic organization of the cerebral vasculature or to known differences in the innervation patterns of the cerebral vessels. Neuronal activity is the principal energy-consuming process in the brain. Local cerebral blood flow adjusts to the level of energy generation; therefore, it is the activity in the neuronal circuits that is the major determinant of variations and regional patterns of cerebral blood flow. Normally there is exquisite coupling between the regional cerebral metabolic demand for oxygen ...
During incubation of antipyrine, but not amidopyrine, 4-aminoantipyrine and 4-leucylaminoantipyrine, with rat liver microsomaland cytosol fractions in the presence of NADPH-generating system a reactive metabolite, which binds with glutathione is form
0248] The term "analyte," as used herein, is a broad term and is used in its ordinary sense, including, without limitation, to refer to a substance or chemical constituent in a biological fluid (for example, blood, interstitial fluid, cerebral spinal fluid, lymph fluid or urine) that can be analyzed. Analytes may include naturally occurring substances, artificial substances, metabolites, and/or reaction products. In some embodiments, the analyte for measurement by the sensor heads, devices, and methods is analyte. However, other analytes are contemplated as well, including but not limited to acarboxyprothrombin; acylcarnitine; adenine phosphoribosyl transferase; adenosine deaminase; albumin; alpha-fetoprotein; amino acid profiles (arginine (Krebs cycle), histidine/urocanic acid, homocysteine, phenylalanine/tyrosine, tryptophan); andrenostenedione; antipyrine; arabinitol enantiomers; arginase; benzoylecgonine (cocaine); biotinidase; biopterin; c-reactive protein; carnitine; carnosinase; CD4; ...
The infant was found unresponsive in bed, face down on a pillow, and emergency efforts to resuscitate him were unsuccessful. The official cause of death was attributed to sudden infant death syndrome (SIDS); however, a toxicological evaluation revealed a concentration of 3.48 mg/L of benzocaine, a widely used local anesthetic found in many over-the-counter medications. Benzocaine is a relatively safe local anesthetic, but there are two recognized adverse reactions, allergic sensitization and methemoglobinemia. Methemoglobin is hemoglobin with the iron oxidized to the ferric state (rather than the reduced ferrous state), making it incapable of reversibly binding oxygen. Death may result from methemoglobinemia if medical intervention is delayed. The corners investigation of the source of the benzocaine in the infant found that he was treated with Zenith Goldline Allergen Ear Drops, which contained 0.25 percent w/v benzocaine and 5.4 percent w/v antipyrine. A caregiver admitted that on the day ...

Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. | Drug Metabolism &...Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. | Drug Metabolism &...

Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Thus, antipyrine clearance is indeed a general measure of P450 oxidative capacity, with a slight to moderate weight toward 1A2 ...
more infohttp://dmd.aspetjournals.org/content/24/4/487

node:field first name] Antipyrine | Kunsthal Aarhusnode:field first name] Antipyrine | Kunsthal Aarhus

Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. Forlaget udgiver titler inden for kunst, ... Antipyrine er en åben situation, arbejder ofte kollektivt og researchbaseret, med et bagkatalog af komplekse og polemiske ... Antipyrine organiserer seminarer, workshops og udstillinger, driver boghandel i Kunsthal Aarhus og udgiver tidsskriftet ... Monsieur Antipyrine, der redigeres af kunstner Jørgen Michaelsen, kunsthistoriker Mikkel Bolt og forfatterne Mikkel Thykier og ...
more infohttp://kunsthal.dk/participants/nodefieldfirstname-antipyrine

Antipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly | IslandScholarAntipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly | IslandScholar

Antipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly. Primary tabs. * ... Engelking, L. R., Lofstedt, J., Blyden, G. T., & Greenblatt, D. J. (1987). Antipyrine and lidocaine are cleared faster in ... Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and ... Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and ...
more infohttp://www.islandscholar.ca/islandora/object/ir:ir-batch6-2448

Antipyrine-Benzocaine Otic: MedlinePlus Drug InformationAntipyrine-Benzocaine Otic: MedlinePlus Drug Information

Antipyrine-Benzocaine Otic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... When antipyrine and benzocaine is used to relieve ear pain, it is usually used every 1 to 2 hours as needed. When antipyrine ... Before using antipyrine and benzocaine otic,. *tell your doctor and pharmacist if you are allergic to antipyrine or benzocaine ... Antipyrine and benzocaine are in a class of medications called analgesics. The combination of antipyrine and benzocaine works ...
more infohttps://medlineplus.gov/druginfo/meds/a607073.html

Antipyrine - DrugBankAntipyrine - DrugBank

Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From ... Antipyrine and Benzocaine. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Liquid. Topical. Directrx. 2014-01-01. 2014-12-31. ... Antipyrine and Benzocaine. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Solution. Auricular (otic). Boca Pharmacal, Inc.. ... Acella Antipyrine and Benzocaine Otic. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Solution. Auricular (otic). Acella ...
more infohttps://www.drugbank.ca/drugs/DB01435

antipyrine and benzocaine otic | Cignaantipyrine and benzocaine otic | Cigna

Benzocaine is a local anesthetic (numbing medicine). Antipyrine and benzocaine otic (for use in the ears) is a combination ... To use the ear drops for ear wax removal, use antipyrine and benzocaine otic 3 times per day for up to 3 days. This will help ... What is the most important information I should know about antipyrine and benzocaine otic?. Medicinal use of this product to ... Antipyrine and benzocaine otic is for use only in your ears. Avoid getting this medicine in your mouth or eyes. If it does get ...
more infohttps://www.cigna.com/healthwellness/hw/medications/antipyrine-and-benzocaine-otic-d03627a1

Antipyrine/benzocaine/phenylephrine otic Disease Interactions - Drugs.comAntipyrine/benzocaine/phenylephrine otic Disease Interactions - Drugs.com

Comprehensive disease interaction information for antipyrine/benzocaine/phenylephrine otic. Includes Otic Agents - Perforated ... There are 4 disease interactions with antipyrine / benzocaine / phenylephrine otic:. Major Otic Agents (Includes Antipyrine/ ... antipyrine / benzocaine / phenylephrine otic drug Interactions. There is 1 drug interaction with antipyrine / benzocaine / ... Topical Sympathomimetics (Includes Antipyrine/benzocaine/phenylephrine otic) ↔ Bph. Moderate Potential Hazard, Moderate ...
more infohttps://www.drugs.com/disease-interactions/antipyrine-benzocaine-phenylephrine-otic.html

Antipyrine/benzocaine/zinc acetate otic Drug Interactions - Drugs.comAntipyrine/benzocaine/zinc acetate otic Drug Interactions - Drugs.com

View drug interactions with antipyrine/benzocaine/zinc acetate otic. This medication may also interact with certain foods or ... Antipyrine / benzocaine / zinc acetate otic is in the drug class otic anesthetics. Antipyrine / benzocaine / zinc acetate otic ... More about antipyrine/benzocaine/zinc acetate otic. *Antipyrine/benzocaine/zinc acetate otic Side Effects ... Antipyrine / benzocaine / zinc acetate otic disease interactions. There is 1 disease interaction with antipyrine / benzocaine ...
more infohttps://www.drugs.com/drug-interactions/antipyrine-benzocaine-zinc-acetate-otic.html

Antipyrine mixture with benzocaine | C20H23N3O3 - PubChemAntipyrine mixture with benzocaine | C20H23N3O3 - PubChem

Antipyrine mixture with benzocaine , C20H23N3O3 , CID 173924 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/173924

Antipyrine pharmaceutical drugs and health productsAntipyrine pharmaceutical drugs and health products

Antipyrine indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information ... Antipyrine. Aspirin. Caffeine AB FE - Camps Antipyrine. Benzalkonium Chloride. Boric Acid. Zinc Sulfate Eye Brite - Lambert Kay ... Antipyrine. Diminazene. Vitamin B12 Ganaseg Plus - Novartis Antipyrine. Peru Balsam. Phenol. Sodium Salicylate. Zinc Oxide ... Antipyrine. Chlorobutanol. Chlorpheniramine Maleate. Phenylephrine Hydrochloride Phenil - Sunways India Antipyrine. Cimicifuga ...
more infohttp://drugs-about.com/ing/antipyrine.html

Antipyrine and benzocaine (Otic route)Antipyrine and benzocaine (Otic route)

Antipyrine and benzocaine combination is used in the ear to help relieve the pain, swelling, and congestion of some ear ... Antipyrine and benzocaine (Otic route). Pronunciation:. an-tee-PYE-reen, BEN-zoe-kane ... Although there is no specific information comparing use of antipyrine and benzocaine in the elderly with use in other age ... The presence of other medical problems may affect the use of antipyrine and benzocaine combination. Make sure you tell your ...
more infohttps://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/600009.htm

Antipyrine and benzocaine ear drops - WikipediaAntipyrine and benzocaine ear drops - Wikipedia

"ANTIPYRINE WITH BENZOCAINE - OTIC". MedicineNet.com. "Auralgan (Antipyrine, Benzocaine, and Glygerin dehydrated) Drug ... Antipyrine 54 mg Benzocaine 14 mg Glycerin and Hydroxyquinoline Sulfate USP A/B otic drops are effective because antipyrine ... Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. It combines ... In 2008, Auralgan was reformulated to include acetic acid and U-polycosanol 410, in addition to antipyrine and benzocaine. Due ...
more infohttps://en.wikipedia.org/wiki/Antipyrine_and_benzocaine_ear_drops

Antipyrine definition and meaning | Collins English DictionaryAntipyrine definition and meaning | Collins English Dictionary

Antipyrine definition: a drug formerly used to reduce pain and fever . Formula: C 11 H 12 N 2 O , Meaning, pronunciation, ... antipyrine in American. (ˌæntaɪˈpaɪˌrin ; anˌtīpīˈrēnˌ; ˌæntiˈpaɪˌrin ; anˌtēpīˈrēnˌ; ˌæntɪˈpaɪˌrin ; anˌtipīˈrēnˌ; ... antipyrine is in the lower 50% of commonly used words in the Collins dictionary ...
more infohttps://www.collinsdictionary.com/dictionary/english/antipyrine

Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Side Effects, Interactions, Warning, Dosage & UsesAuralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Side Effects, Interactions, Warning, Dosage & Uses

Antipyrine, Benzocaine and Glycerin Dehydrated) may treat, uses, dosage, side effects, drug interactions, warnings, patient ... Instill Auralgan (antipyrine, benzocaine and glycerin dehydrated) permitting the solution to run along the wall of the canal ... After: Auralgan (antipyrine, benzocaine and glycerin dehydrated) is useful for drying out the canal or relieving discomfort. ... Auralgan (antipyrine, benzocaine and glycerin dehydrated) does not blanch the tympanic membrane or mask the landmarks and, ...
more infohttps://www.rxlist.com/auralgan-drug.htm

Antipyrine Half-Life and Metabolism | Drug Metabolism & DispositionAntipyrine Half-Life and Metabolism | Drug Metabolism & Disposition

Thank you for sharing this Drug Metabolism & Disposition article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
more infohttp://dmd.aspetjournals.org/content/2/4/396.1

Patent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google PatentsPatent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google Patents

... and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard ... The nature of the mechanism by which the antipyrine compound acts is not known. Although the antipyrine compound can act as a ... Preferably, the antipyrine compound is an aminoantipyrine, and more preferably 4-aminoantipyrine. The antipyrine compound is ... Also, for purposes of this invention, the term antipyrine compound is meant to include antipyrine and derivatives and salts ...
more infohttp://www.google.com/patents/US5824491?dq=mezick

Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGESMicro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGES

Antipyrine and indomethacin loading was 6-78% in these micro-/mesoporous carbons. The signatures in thermogravimetric studies ... We have employed two mesoporous and two microporous carbons for the sustained release of one water-soluble drug (antipyrine) ... Accepted Manuscript: Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin ...
more infohttps://www.osti.gov/pages/biblio/1325496-micro-mesoporous-carbons-controlled-release-antipyrine-indomethacin

Does antipyrine, benzocaine and glycerin interact with other drugs? | Anesthetic Agent - SharecareDoes antipyrine, benzocaine and glycerin interact with other drugs? | Anesthetic Agent - Sharecare

Before using antipyrine, benzocaine and glycerin, tell your doctor about any prescription and over-the-cou ... Before using antipyrine, benzocaine and glycerin, tell your doctor about any prescription and over-the-counter medicines, ... Your doctor will determine whether the benefits of using antipyrine, benzocaine and glycerin outweigh the risks. Also, ask your ...
more infohttps://www.sharecare.com/health/anesthetic-drugs/interactions-antipyrine-benzocaine-dehydrated

Veterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.netVeterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.net

Diminazene Aceturate 140 mg Antipyrine 750 mg Description: Diminazene Aceturate + Antipyrine ready to use... ... Veterinary Diminazene Aceturate Antipyrine injection Common Name: Veterinary Diminazene Aceturate Phenazone injection Strength ...
more infohttps://www.ecplaza.net/products/veterinary-diminazene-aceturate-antipyrine-injection_4001149

Veterinary Products Phenazone API Grade High Quality AntipyrineVeterinary Products Phenazone API Grade High Quality Antipyrine

... high quality gearbox of Veterinary Products Phenazone API Grade High Quality Antipyrine can adjust the speed timely, avoiding ... Veterinary Products Phenazone API Grade High Quality Antipyrine can improve the nutrition digestion and absorption, ... Veterinary Products Phenazone API Grade High Quality Antipyrine, dry materials processing, the feed particles with high ... It is a professional manufacturer and exporter who Veterinary Products Phenazone API Grade High Quality Antipyrine upon animal ...
more infohttp://www.digit-life.com/food-52118345-veterinary-products-phenazone-api-grade-high-quality-antipyrine.html

Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, CAS Number: 8017-81-0Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, CAS Number: 8017-81-0

Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt - chemical information, properties, structures, articles, patents ... Featured suppliers/resources for Antipyrine, 4-(methylamino)-, monomet... List your site here ... Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, (Antipyrinylmethylamino)methanesulfonic acid sodium salt, ( ... 4-Sodium methanesulfonate methylamine-antipyrine, 57904-20-8, 5907-38-0, 68-89-3, 8017-81-0, Alginodia, Algocalmin, Algopyrin, ...
more infohttp://www.chemindustry.com/chemicals/03889534.html

Antipyrine patents and clinical trials: Drug pipeline profiles for drugs in developmentAntipyrine patents and clinical trials: Drug pipeline profiles for drugs in development

Antipyrine. European Patent Office. 3192791. 2034-09-11. Start Trial. Antipyrine. Japan. WO2016039408. 2034-09-11. Start Trial ... Antipyrine is an investigational drug.. There have been 5 clinical trials for Antipyrine. The most recent clinical trial was a ... Antipyrine. Australia. 2006269422. 2025-07-07. Start Trial. >Drugname. >Country. >Document Number. >Estimated Expiration. > ... Antipyrine. Start Trial. Devices and methods for continuous analyte monitoring. DexCom, Inc. (San Diego, CA) Start Trial. ...
more infohttps://www.drugpatentwatch.com/p/drugs-in-development/drugname/Antipyrine

Fenfluramine Therapy in Non-insulin-dependent Diabetic Patients: Effects on Body Weight, Glucose Homeostasis, Serum...Fenfluramine Therapy in Non-insulin-dependent Diabetic Patients: Effects on Body Weight, Glucose Homeostasis, Serum...

The effect of fenfluramine on hepatic drug metabolism was assessed by using the antipyrine test. F did not cause significant ... changes in antipyrine metabolism. Fenfluramine therefore seems to be useful as an adjunct to diet and SU therapy in obese non- ...
more infohttp://care.diabetesjournals.org/content/4/5/535

Is benzocaine and antipyrine otic solution used for swimmers ear? - Answered by top doctors on HealthTapIs benzocaine and antipyrine otic solution used for swimmer's ear? - Answered by top doctors on HealthTap

Is antipyrine-benzocaine ear drop used for tmj? * Could I use antipyrine-benzocaine ear drops in adults, if so, whats the ... Is antipyrine-benzocaine ear drop used for tmj? * Could I use antipyrine-benzocaine ear drops in adults, if so, whats the ... Does antipyrine-benzocaine otic help for swimmers ear? * Can antipyrine and benzocaine solution be used for swimmers ear pain? ... What is antipyrine and benzocaine otic solution, USP used for? * Does antipyrine and benzocaine otic solution have a steroid in ...
more infohttps://www.healthtap.com/user_questions/140697-is-benzocaine-and-antipyrine-otic-solution-used-for-swimmer-s-ear
  • We have developed a sensitive method for the measurement of antipyrine metabolites formed in the in vitro incubations and applied it to determine the P450s participating in the formation of each metabolite in human liver microsomes. (aspetjournals.org)
  • The plasma disappearance rate of antipyrine in 18 patients with extrahepatic cholestasis and 11 patients with intrahepatic cholestasis was compared with that of two groups of control subjects without liver disease who were matched for age. (eurekamag.com)
  • The antipyrine metabolic clearance rate (MCR) was studied in two groups of patients with similar degrees of cholestasis and hepatic damage, but differing mechanisms of cholestasis. (eurekamag.com)
  • It is a professional manufacturer and exporter who Veterinary Products Phenazone API Grade High Quality Antipyrine upon animal pharmaceuticals. (digit-life.com)
  • The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. (google.com)
  • The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. (google.com)
  • and an antipyrine compound, wherein the antipyrine compound produces a standard curve of analyte concentration versus reflectance which is substantially linear in the desired range when the analyte contacts the reagent detecting chemistry. (google.com)
  • Antipyrine and benzocaine otic (for use in the ears) is a combination medicine used to treat pain and swelling caused by ear infections. (cigna.com)
  • Although there is no specific information comparing use of antipyrine and benzocaine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. (allinahealth.org)
  • The present invention relates to dry reagent test strips useful for detecting analytes in body fluids, and particularly to stable test strips comprising a matrix containing reagent detection chemistry including a benzidine type dye precursor and an antipyrine compound. (google.com)
  • Veterinary Products Phenazone API Grade High Quality Antipyrine adopts world-class technology to customize and produce special racks. (digit-life.com)
  • Whereas no significant difference was observed for the antipyrine MCR between patients with extrahepatic cholestasis and their controls [30.7 +/- 11.2 (SD) as against 31.6 +/- 10.0 ml/min], the antipyrine MCR was significantly lower (P less than 0.001) in the patients with intrahepatic cholestasis than in their controls (16.2 +/- 4.5 vs 37.4 +/- 17.3 ml/min). (eurekamag.com)