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AntipyrineHalf-LifeMetabolic Clearance RateSparteineGlucaric AcidSalivaTrimethadioneIndocyanine GreenPhenobarbitalHexobarbitalAminopyrineDebrisoquinCimetidineHeparinoidsLiver Function TestsDimethadioneOccupational MedicineBenzidinesDipterocarpaceaeReagent StripsPatents as TopicPeroxidasesImmunochromatographyGlycerolDrug InteractionsMethemoglobinemiaAnesthetics, LocalProduct LabelingToothachePorositySilicon DioxideIndomethacinAdsorptionMucinsCarbonDictionaries, MedicalDictionaries as TopicDictionaries, ChemicalPhoneticsLanguageSpeechDiminazeneTrypanosoma congolenseTrypanosomiasis, AfricanTrypanocidal AgentsPentamidineVeterinary MedicineFenfluramineDiet TherapyCross-Over StudiesDiabetes Mellitus, Type 1PregnatrienesMetergoline
Antipyrine
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Half-Life
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Metabolic Clearance Rate
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Sparteine
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype.
Glucaric Acid
A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.
Saliva
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Trimethadione
An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Indocyanine Green
A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
Phenobarbital
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Hexobarbital
A barbiturate that is effective as a hypnotic and sedative.
Aminopyrine
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.
Debrisoquin
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Cimetidine
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Heparinoids
Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)
Liver Function Tests
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Dimethadione
An anticonvulsant that is the active metabolite of TRIMETHADIONE.
Occupational Medicine
Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.
Benzidines
Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.
Dipterocarpaceae
A plant family of the order Theales.
Reagent Strips
Narrow pieces of material impregnated or covered with a substance used to produce a chemical reaction. The strips are used in detecting, measuring, producing, etc., other substances. (From Dorland, 28th ed)
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Peroxidases
Immunochromatography
A type of affinity chromatography where ANTIBODIES are used in the affinity capture reaction on the solid support, in the mobile phase, or both.
Glycerol
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Methemoglobinemia
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Product Labeling
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
Toothache
Pain in the adjacent areas of the teeth.
Porosity
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Silicon Dioxide
Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
Indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Adsorption
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
Mucins
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Carbon
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Dictionaries, Chemical
Phonetics
The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)
Language
A verbal or nonverbal means of communicating ideas or feelings.
Speech
Communication through a system of conventional vocal symbols.
Diminazene
An effective trypanocidal agent.
Trypanosoma congolense
A species of Trypanosome hemoflagellates that is carried by tsetse flies and causes severe anemia in cattle. These parasites are also found in horses, sheep, goats, and camels.
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Trypanocidal Agents
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
Pentamidine
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Veterinary Medicine
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
Fenfluramine
A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
Diet Therapy
By adjusting the quantity and quality of food intake to improve health status of an individual. This term does not include the methods of food intake (NUTRITIONAL SUPPORT).
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Pregnatrienes
Pregnane derivatives containing three double bonds in the ring structures.
Metergoline
A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.

Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining. (1/491)

BACKGROUND AND PURPOSE: After short periods of ischemia, commonly used staining methods yield only moderate differences in optical contrast between normal and damaged brain tissue when gray-scale images are used for computer-assisted image analysis. We describe a high-contrast silver infarct staining (SIS) method that allows an early delineation of ischemic tissue as soon as 2 hours after middle cerebral artery occlusion (MCAO) in rat brain cryosections. METHODS: Rats were subjected to permanent MCAO for 2, 4, 6, and 48 hours. The optical densities were quantified in nonischemic white and gray matter and in damaged tissue from gray-scale images of serial sections with the use of a video camera-based image analyzing system. SIS, hematoxylin-eosin, Nissl, and nitroblue tetrazolium stainings were performed in cryosections, and 2,3, 5-triphenyltetrazolium hydrochloride (TTC) staining was performed in unfrozen vibratome sections. In addition, the range of reduced cerebral blood flow (CBF) in areas demarcated by SIS was determined in iodo[14C]antipyrine autoradiograms of adjacent cryosections. RESULTS: At all times after MCAO, only SIS showed significantly (P<0.01) lower optical densities in damaged than in normal brain tissue for both white and gray matter. TTC staining was as effective as SIS 6 and 48 hours after MCAO. The tightest correlation between areas of reduced SIS and of reduced CBF was found at a mean ischemic CBF of 22.3 mL/100 g per minute. This corresponds to a CBF range of 0 to 44 mL/100 g per minute in areas of reduced SIS. CONCLUSIONS: In contrast to other staining methods, SIS allows a reliable delineation of ischemic brain tissue (core plus penumbra) from nonischemic white and gray matter of rat brain cryosections as soon as 2 hours after MCAO.  (+info)

Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat. (2/491)

Studies with positron-emission tomography have indicated that muscarinic acetylcholine receptors may be involved in the mechanism of enhancement of cerebral blood flow (CBF) by neuronal functional activation. We examined the effects of muscarinic receptor blockade by scopolamine on the local CBF responses to vibrissal stimulation in the whisker-to-barrel cortex sensory pathway in unanesthetized rats. Local CBF was measured by the quantitative autoradiographic [(14)C]iodoantipyrine method. Scopolamine (0.4 or 0.8 mg/kg) was injected i.v. 30 min before measurement of local CBF; control rats received equivalent volumes of physiological saline. Vibrissae on the left side of the face were stroked continuously throughout the 1-min period of measurement of CBF. Local CBF was determined bilaterally in four structures of the pathway, i.e., spinal and principal sensory trigeminal nuclei, ventral posteromedial thalamic nucleus, and barrel field of the sensory cortex, as well as in four representative structures unrelated to the pathway. The higher dose of scopolamine raised baseline CBF in the two trigeminal nuclei, but neither dose diminished the percentage of increases in local CBF because of vibrissal stimulation in any of the stations of the pathway. These results do not support involvement of muscarinic receptors in the mechanism of enhancement of local CBF by functional neuronal activation, at least not in the whisker-barrel cortex sensory pathway in the unanesthetized rat.  (+info)

Cerebrovascular reactivity to CO(2) and hypotension after mild cortical impact injury. (3/491)

Cerebrovascular reactivity to CO(2) or hypotension was studied in vivo and in vitro [pressurized arteries ( approximately 82 micrometer) and arterioles ( approximately 30 micrometer)] at 1 h after mild controlled cortical impact (CCI) injury in rats. The cortical perfusion response [assessed using laser-Doppler flowmetry (LDF)] to altered CO(2) was diminished (up to 81%) after mild CCI injury. The responses to CO(2) alterations in arteries and arterioles isolated from the injured cortex were similar to responses in vessels isolated from sham-injured animals. After mild CCI injury, the autoregulatory response to hypotension (measured using LDF) was maintained or even enhanced, depending on the method used to measure the response. Vessels isolated from the injury site showed a response to changes in pressure similar to that in vessels isolated from sham-injured rats. We conclude that mild CCI injury produces complicated alterations in cerebrovascular control. Whereas the autoregulatory response to hypotension was maintained or even enhanced, the in vivo vascular response to CO(2) was severely compromised. The altered response to CO(2) was not caused by an intrinsic vascular perturbation but rather an altered milieu after mild CCI injury.  (+info)

Direct detection of antipyrine metabolites in rat urine by (13)C labeling and NMR spectroscopy. (4/491)

Antipyrine is a useful probe to evaluate variation of in vivo activities of oxidative hepatic drug-metabolizing enzymes. Here we describe a new approach using (13)C labeling and NMR spectroscopy for the direct and simultaneous detection of all phase I and phase II metabolites of antipyrine in rat urine. [C-methyl-(13)C]Antipyrine was synthesized and administered orally to rats (100 mg/kg), and the 0- to 24-h postdose urine was analyzed by 100-MHz (13)C NMR spectroscopy under the conditions of distortionless enhancement by polarization transfer without any pretreatments such as deconjugation, chromatographic separation, and solvent extraction. Consequently, all the major metabolites in urine were successfully detected with favorable signal-to-noise ratios in the limited acquisition time (30 min). The assignments of the resonances were performed by enzymic modification and spiking authentic samples. The reproducibility of the NMR detection was sufficient for the quantitative evaluation of the metabolic profile. Effects of 3-methylcholanthrene on antipyrine metabolism were examined by this approach to evaluate variation of in vivo phase I and phase II metabolism of antipyrine in rats. The present approach is useful and practical to evaluate variation of in vivo activities of conjugation enzymes as well as oxidation enzymes responsible for the formation of antipyrine metabolites in rats. This direct approach would enhance the value of the antipyrine test because of the simplicity and convenience.  (+info)

Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide. (5/491)

Klebsiella pneumoniae endotoxin has been found to decrease hepatic P450-mediated drug-metabolizing enzyme activity in a time-dependent manner. In this study, we investigated the role of nitric oxide (NO) in the decrease in hepatic drug-metabolizing enzyme activity caused by endotoxin in vivo. We measured in vivo pharmacokinetic parameters of antipyrine in rats treated with endotoxin and/or a selective inhibitor of inducible NO synthase (iNOS), S-methylisothiourea. Intraperitoneal injection of endotoxin (1 mg/kg of body weight) dramatically decreased the systemic clearance of antipyrine, reflecting reduced hepatic drug-metabolizing enzyme activity, and significantly increased the level of nitrite and nitrate (NOx) in the plasma. S-Methylisothiourea (10 mg/kg) reversed this decreasing antipyrine clearance and reduced the level of NOx in plasma. Repeated injections of an NO donor, (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK-409; 10 mg/kg), at a dose which maintained plasma NOx at the same levels as those caused by endotoxin injection, also decreased the systemic clearance of antipyrine. These findings suggest that the overproduction of NO observed in this animal model is at least partially responsible for the significant reduction in the hepatic drug-metabolizing enzyme activity that may happen in a gram-negative bacterial infection.  (+info)

Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. (6/491)

Recirculatory pharmacokinetic models for indocyanine green (ICG), inulin, and antipyrine describe intravascular mixing and tissue distribution after i.v. administration. These models characterized physiologic marker disposition in four awake, splenectomized dogs while they were normovolemic, volume loaded (15% of estimated blood volume added as a starch solution), and mildly and moderately hypovolemic (15 and 30% of estimated blood volume removed). ICG-determined blood volumes increased 20% during volume loading and decreased 9 and 22% during mild and moderate hypovolemia. Dye (ICG) dilution cardiac output (CO) increased 31% during volume loading and decreased 27 and 38% during mild and moderate hypovolemia. ICG-defined central and fast peripheral intravascular circuits accommodated blood volume alterations and the fast peripheral circuit accommodated blood flow changes. Inulin-defined extracellular fluid volume contracted 14 and 21% during hypovolemia. Early inulin disposition changes reflected those of ICG. The ICG and inulin elimination clearances were unaffected by altered blood volume. Neither antipyrine-defined total body water volume nor antipyrine elimination clearance changed with altered blood volume. The fraction of CO not involved in drug distribution had a significant effect on the area under the antipyrine concentration-versus-time relationships (AUC) in the first minutes after drug administration. Hypovolemia increased the fraction of CO represented by nondistributive blood flow and increased the antipyrine AUC up to 60% because nondistributive blood flow did not change, despite decreased CO. Volume loading resulted in a smaller (less than 20%) antipyrine AUC decrease despite increased fast tissue distributive flow because nondistributive flow also increased with increased CO.  (+info)

Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective. (7/491)

BACKGROUND: Differences in the pharmacokinetics of the enantiomers of ketamine have been reported. The authors sought to determine whether these differences extend to pulmonary uptake and peripheral tissue distribution and to test the hypothesis that tissue distribution of the stereoisomers differs because of carrier-mediated drug transport. METHODS: The dispositions of markers of intravascular space and blood flow (indocyanine green, ICG) and total body water and tissue perfusion (antipyrine) were determined along with S-(+)- and R-(-)-ketamine in five mongrel dogs. The dogs were studied while anesthetized with 2.0% halothane. Marker and drug dispositions were described by recirculatory pharmacokinetic models based on frequent early and less-frequent later arterial blood samples. These models characterize pulmonary uptake and the distribution of cardiac output into parallel peripheral circuits. RESULTS: Plasma elimination clearance of the S-(+)-ketamine enantiomer, 29.9 ml x min(-1) x kg(-1), was higher than that of the R-(-)-enantiomer, 22.2 ml x min(-1) x kg(-1). The apparent pulmonary tissue volumes of the ketamine S-(+) and R-(-)-enantiomers (0.31 l) did not differ and was approximately twice that of antipyrine (0.16 l). The peripheral tissue distribution volumes and clearances and the total volume of distribution (2.1 l/kg) were the same for both stereoisomers when elimination clearances were modeled from the rapidly equilibrating peripheral compartment. CONCLUSIONS: Although the elimination clearance of S-(+)-ketamine is 35% greater than that of the R-(-)-enantiomer, there is no difference in the apparent pulmonary tissue volume or peripheral tissue distribution between the stereoisomers, suggesting that physicochemical properties of ketamine other than stereoisomerism determine its perfusion-limited tissue distribution.  (+info)

Evolution of microcirculatory disturbances after permanent middle cerebral artery occlusion in rats. (8/491)

Nonischemic brain capillaries show a continuous and heterogeneous plasma perfusion. In the current study, plasma perfusion was investigated in rats during 2 to 168 hours of permanent middle cerebral artery occlusion. Perfused capillaries were detected in brain cryosections by fluorescein isothiocyanate (FITC) dextran after 10 minutes of circulation time. Heterogeneity of capillary perfusion was identified by Evans blue (EB), which circulated for 3 seconds. In this setting, the heterogeneity of intracapillary EB concentrations reflects heterogeneities in capillary flow velocities. The CBF was quantified by simultaneous iodo[14C]antipyrine autoradiography. When moving from normal flow to low-flow areas in the ischemic hemisphere, three states of capillary filling could be distinguished: state 1--fast perfusion, filling by FITC dextran and EB (CBF 0.33 mL x g(-1) x min(-1)); state 2--delayed perfusion, only FITC dextran filling (CBF 0.104 mL x g(-1) x min(-1)); state 3--minimal perfusion, no dye filling (CBF 0.056 mL x g(-1) x min(-1)). In tissue of state 1 at the borderline to ischemic tissue, a higher heterogeneity of intracapillary EB concentration (85.7%) was found than in the contralateral nonischemic hemisphere (76.4%) (P < 0.05), indicating a compromised microcirculation. The adjacent ischemic areas were filled by FITC dextran (state 2) 2 to 4 hours after middle cerebral artery occlusion, indicating a maintained, although slow, perfusion at this time. Later, minimal perfused areas (state 3) progressively replaced the delayed perfused areas (state 2). This study shows, for the first time, the evolution of microvascular disturbances in relation to CBF. In the low-flow areas, an early residual plasma perfusion is later followed by a lack of perfusion or minimal perfusion. In areas of higher, although reduced flow at the border between normal and ischemic tissue, an extreme capillary perfusion heterogeneity indicates permanent microcirculatory abnormalities.  (+info)

Plus itPlus it
Antipyrine biotransformation has been used extensively in clinical studies as a marker for general hepatic oxidative or cytochrome P450 (P450)-mediated, metabolism. Studies have indicated that more than one P450 is involved in the formation of the three major human metabolites, 4-hydroxyantipyrine, norantipyrine, and 3-hydroxymethylantipyrine. However, the specific P450s involved have not yet been determined. We have developed a sensitive method for the measurement of antipyrine metabolites formed in the in vitro incubations and applied it to determine the P450s participating in the formation of each metabolite in human liver microsomes. The identification of these P450s was accomplished through the use of simple and multivariate regression analysis, selective chemical inhibitors, and microsomes containing cDNA-expressed enzymes. These methods implicated P450s 1A2, 3A, and 2A6 in the formation of 4-hydroxyantipyrine. The predominant form involved in 3-hydroxymethylantipyrine formation was found ...
http://dmd.aspetjournals.org/content/24/4/487
Antipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly | IslandScholarAntipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly | IslandScholar
The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function Show moreThe following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function ...
http://www.islandscholar.ca/islandora/object/ir:ir-batch6-2448
node:field first name] Antipyrine | Kunsthal Aarhusnode:field first name] Antipyrine | Kunsthal Aarhus
Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. Forlaget udgiver titler inden for kunst, litteratur og teori; økonomi, teknologi, vandalisme, publicering som medium og praksis, skizofreni, science fiction og konceptuel poesi. Antipyrine er en åben situation, arbejder ofte kollektivt og researchbaseret, med et bagkatalog af komplekse og polemiske titler, der formulerer visioner i sin tid. Antipyrine organiserer seminarer, workshops og udstillinger, driver boghandel i Kunsthal Aarhus og udgiver tidsskriftet Monsieur Antipyrine, der redigeres af kunstner Jørgen Michaelsen, kunsthistoriker Mikkel Bolt og forfatterne Mikkel Thykier og Claus Handberg.. ...
http://kunsthal.dk/participants/nodefieldfirstname-antipyrine
Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokinesEdaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines
References. 1. Day HL, Taylor RM. The liver. Part 5: acute liver failure. Nurs Times 2006; 102: 26-27. [ Links ] 2. Kawasaki T, Ishihara K, Ago Y, Nakamura S, Itoh S, Baba A, et al. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. Eur J Pharmacol 2006; 542: 92-99, doi: 10.1016/j.ejphar.2006.05.012. [ Links ] 3. Yang T, Mao YF, Liu SQ, Hou J, Cai ZY, Hu JY, et al. Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. Eur J Pharmacol 2010; 630: 152-157, doi: 10.1016/j.ejphar.2009.12.025. [ Links ] 4. Okatani Y, Wakatsuki A, Enzan H, Miyahara Y. Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 2003; 465: 163-170, doi: 10.1016/S0014-2999(03)01463-8. [ Links ] 5. Ito K, Ozasa H, Noda Y, Arii S, Horikawa S. Effects of free radical scavenger on acute liver injury induced by d-galactosamine and ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300231&lng=en&tlng=en
Plus itPlus it
Rifampin is known to be an important stimulus to drug-metabolizing enzymes and can also induce the production of alpha 1-acid glycoprotein (AGP). We have studied the time course for induction of drug metabolizing capability as assessed by the clearance of antipyrine and the plasma concentration of AGP following a chronic course of rifampin in dogs. The kinetics of the induction process were observed during a 22-day treatment period, and the wash-out period kinetics were followed for another 3 weeks. Rifampin kinetics were measured at the end of the 22-day dosing period. Both antipyrine clearance and AGP concentration were significantly increased by the rifampin treatment; antipyrine clearance doubled and AGP concentrations nearly tripled. When analyzed by a newly developed kinetic model of induction, it was determined that the time course for AGP or antipyrine clearance was not governed by a single rate constant. The second rate constant did not represent the accumulation or persistence of ...
http://dmd.aspetjournals.org/content/14/1/46
Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGESMicro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGES
Here, we have demonstrated the potential of meso- and microporous carbons in controlled release applications and targeted oral drug delivery. We have employed two mesoporous and two microporous carbons for the sustained release of one water-soluble drug (antipyrine) and one water-insoluble drug (indomethacin), using these as models to examine the controlled release characteristics. The micro-/mesoporous carbons were characterized as having a BET surface area of 372-2251 m 2 g -1 and pore volume 0.63-1.03 cm 3 g -1. The toxicity studies with E. coli bacterial cells did not reveal significant toxicity, which is in accordance with our previous studies on human cells with similar materials. Mucin adsorption tests with type III pork mucin demonstrated 20-30% mucin adsorption by the carbon samples and higher mucin adsorption could be attributed to higher surface area and more oxygen functionalities. Antipyrine and indomethacin loading was 6-78% in these micro-/mesoporous carbons. The signatures in ...
https://www.osti.gov/pages/biblio/1325496-micro-mesoporous-carbons-controlled-release-antipyrine-indomethacin
AOAC 968.42-1969, Benzocaine and antipyrine in drugs. Spectropho - $14.30 : AOAC Official MethodAOAC 968.42-1969, Benzocaine and antipyrine in drugs. Spectropho - $14.30 : AOAC Official Method
AOAC Official Method AOAC 968.42-1969, Benzocaine and antipyrine in drugs. Spectropho - The files are in electronic format(PDF/DOC/DOCX) and will be sent to your email within 24 hours. Test Method:AOAC 968.42-1969Title:Benzocaine and antipyrine in drugs. Spectrophotometric methodPages:2
http://www.aoacofficialmethod.org/index.php?main_page=product_info&cPath=1&products_id=444
Post-Hoc Analysis of Phase 3 Study Examines Effect of Early Intervention with Edaravone on Survival and Disease Progression...Post-Hoc Analysis of Phase 3 Study Examines Effect of Early Intervention with Edaravone on Survival and Disease Progression...
JERSEY CITY, N.J. - Mitsubishi Tanabe Pharma America, Inc. (MTPA) today announced a post-hoc analysis of its Phase 3 edaravone study reviewing the results of intravenous (IV) edaravone treatment on disease progression milestones and events among people with amyotrophic lateral sclerosis (ALS). In the analysis, a risk reduction was observed for the exploratory composite estimate of time to death, tracheostomy, permanent assisted ventilation (PAV), and hospitalization. The data was highlighted as an oral presentation at the 2021 Muscular Dystrophy Association Clinical & Scientific Virtual Conference.. While the Phase 3 edaravone study was not designed with survival as an endpoint, this post-hoc analysis allows us to explore insights on the results of early treatment intervention on survival-related events due to ALS progression, including death, hospitalization, ventilation and tracheostomy, said Atsushi Fujimoto, President, MTPA. We are committed to putting patients first in everything we do, ...
https://checkorphan.org/news/post-hoc-analysis-of-phase-3-study-examines-effect-of-early-intervention-with-edaravone-on-survival-and-disease-progression-milestone-events-in-als-patients/
acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA) Causes, Symptoms, Treatment -...acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA) Causes, Symptoms, Treatment -...
What should I discuss with my healthcare provider before taking acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA)? How should I take acetaminophen, dichloralphenazone, and isometheptene (Epidrin, Midrin, Migquin, Migragesic IDA)?
https://www.emedicinehealth.com/drug-acetaminophen_dichloralphenazone_and_isometheptene/page2_em.htm
COMPARISON OF RATE OF HEPATIC METABOLISM IN VITRO AND HALF-LIFE FOR ANTIPYRINE IN VIVO IN THREE SPECIESCOMPARISON OF RATE OF HEPATIC METABOLISM IN VITRO AND HALF-LIFE FOR ANTIPYRINE IN VIVO IN THREE SPECIES
O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:103:\COMPARISON OF RATE OF HEPATIC METABOLISM IN VITRO AND HALF-LIFE FOR ANTIPYRINE IN VIVO IN THREE SPECIES\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1979\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:7:\MCMANUS\;s:10:\\u0000*\u0000aufirst\;s:2:\ME\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:2:{i:0;s:10:\MCMANUS ME\;i:1;s:8:\ILETT ...
https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL7950400998
Aurodex (Antipyrine / Benzocaine) FDA Package Insert & Drug Facts - Iodine.comAurodex (Antipyrine / Benzocaine) FDA Package Insert & Drug Facts - Iodine.com
Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Aurodex (Antipyrine / Benzocaine)
https://www.iodine.com/drug/antipyrine-benzocaine/fda-package-insert
Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Uses, Dosage, Side Effects, Interactions, WarningAuralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Uses, Dosage, Side Effects, Interactions, Warning
Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
https://www.rxlist.com/auralgan-drug.htm
ChemIDplus - 569-84-6 - DXKXOTURGHVQIW-UHFFFAOYSA-N - Antipyrine mixture with aspirin - Similar structures search, synonyms,...ChemIDplus - 569-84-6 - DXKXOTURGHVQIW-UHFFFAOYSA-N - Antipyrine mixture with aspirin - Similar structures search, synonyms,...
569-84-6 - DXKXOTURGHVQIW-UHFFFAOYSA-N - Antipyrine mixture with aspirin - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/569-84-6
Antipyrine definition and meaning | Collins English DictionaryAntipyrine definition and meaning | Collins English Dictionary
Antipyrine definition: a drug formerly used to reduce pain and fever . Formula: C 11 H 12 N 2 O | Meaning, pronunciation, translations and examples
https://www.collinsdictionary.com/dictionary/english/antipyrine
ISOMETHEPTENE/ ACETAMINOPHEN/ DICHLORALPHENAZONE - ORAL (a-SEE...ISOMETHEPTENE/ ACETAMINOPHEN/ DICHLORALPHENAZONE - ORAL (a-SEE...
Find medical information for ISOMETHEPTENE/ ACETAMINOPHEN/ DICHLORALPHENAZONE - ORAL (a-SEET-a-MIN-oh-fen/EYE-soe-meth-EP-teen/ DYE-klor-al-FEN-a-zone
http://webhealthnetwork.com/drug/6-220/isometheptene-acetaminophen-dichloralphenazone-oral-aseetaminohfeneye
Plus itPlus it
Additional experiments were conducted to examine the disappearance and appearance coefficients of the passive transcellular (antipyrine, 0.2 mM) and paracellular (mannitol, 2.0 mM) markers using the above-mentioned SPIP model (n = 5/group). The gut does not metabolize mannitol and antipyrine and absorbs these two compounds in an unchanged form. The effects of verapamil at 50 μM on the permeability of both antipyrine and mannitol were also investigated.. Cell Culture. Caco-2 cells were obtained from the American Type Culture Collection (Rockville, MD). The control vector MDCKII cell line and its human MDR1 recombinantly transfected derivative, MDR1-MDCKII, were a kind gift from Professor Piet Borst (Netherlands Cancer Institute, Amsterdam, The Netherlands). The cells were cultured in Dulbeccos modified Eagles medium supplemented with 10% fetal bovine serum, 1% nonessential amino acids, and 100 U/ml penicillin and gentamicin. The cells were grown in an atmosphere of 5% CO2 and 90% relative ...
http://jpet.aspetjournals.org/content/317/3/1285
Boghandel | Kunsthal AarhusBoghandel | Kunsthal Aarhus
Antipyrine Bookstore i Kunsthal Aarhus er et nyt samarbejde med det uafhængige forlag Antipyrine. Samarbejdet begyndte i sommeren 2013 med produktionen af en række publikationer, udstillinger, forskning og udstilingen Reading Machines. Boghandlen udvikles gradvist og fyldes med en lang række udgivelser særligt fra små uafhængige forlag og tidsskrifter fra hele verden, indenfor de overordnede emner kunst, litteratur og teori. Herudover vil boghandlen give særlig plads til den tekstbaserede kunst og kunstnerbøger.. Boghandlen vil være en del af Kunsthal Aarhus øvrige program og i varierende omfang reflektere og tilbyde yderligere kontekst til aktuelle udstillinger med særligt udvalgte udgivelser og arrangementer. Herudover vil boghandlen have et eget program med gæsteforlag, små udstillinger af bøger og en række foredrag og boglanceringer i samarbejde med de repræsenterede forlag,tidsskrifter og andre aktører.. Antipyrine Bookstore har omkring 60 små og store udgivere i ...
http://dk.kunsthalaarhus.dk/boghandel
Chemical Database: Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-, (4-bromo-3-nitro- alpha...Chemical Database: Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-, (4-bromo-3-nitro- alpha...
This page contains information on the chemical Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-, (4-bromo-3-nitro- alpha-methylbenzylidene)hydrazide including: 2 synonyms/identifiers.
https://environmentalchemistry.com/yogi/chemicals/cn/Acetic%A0acid%2C%A0%28p-%28%283-methyl-5-oxo-2-pyrazolin-4-ylidene%29methyl%29phenoxy%29-%2C%A0%284-bromo-3-nitro-%A0alpha-methylbenzylidene%29hydrazide.html
Chemical Database: Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-,(4-methoxybenzy lidene)hydrazide ...Chemical Database: Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-,(4-methoxybenzy lidene)hydrazide ...
This page contains information on the chemical Acetic acid, (p-((3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl)phenoxy)-,(4-methoxybenzy lidene)hydrazide including: 2 synonyms/identifiers.
https://environmentalchemistry.com/yogi/chemicals/cn/Acetic%A0acid%2C%A0%28p-%28%283-methyl-5-oxo-2-pyrazolin-4-ylidene%29methyl%29phenoxy%29-%2C%284-methoxybenzy%A0lidene%29hydrazide.html
Preparation and Analysis of 4-lodoantipyrine-(I131) | StrokePreparation and Analysis of 4-lodoantipyrine-(I131) | Stroke
4-Iodoantipyrine was prepared from antipyrine according to the reaction equation:. 3C11H12N2O+2KI+KIO3+3HCl→3C11H11N2OI+3KCl+3H2O. The product was separated from the reaction mixture and purified by recrystallization. The iodoantipyrine was labeled with I131 by means of an exchange reaction with NaI131. It was separated from the unbound radioactivity by anion exchange chromatography.. The purity of the product was determined by cellulose thin layer chromatography using ethanol-chloroform-water (45:45:10) as the solvent system. The purity of the 4-iodoantipyrine-I131 decreased with time due to a splitting off of the I131 atom and subsequent formation of NaI131. This spontaneous deiodination was best minimized by storage in methanol at low temperatures.. ...
http://stroke.ahajournals.org/content/3/4/446
Isometheptene, dichloralphenazone, and acetaminophen (Oral route)Isometheptene, dichloralphenazone, and acetaminophen (Oral route)
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children. Older adults Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly ...
https://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/601889.htm
Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: a systematic review. -...Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: a systematic review. -...
Edaravone has been used in patients with acute ischemic stroke in Japan for over 10 years but does not have marketing authorization in Europe or America. Either patients in Europe and America are not receiving an effective treatment, or those in Asia are being given a treatment which is not effective. Finding out which of these is true will require further clinical trials, and a better understanding of its efficacy in animal models may help inform the design of those trials so that it might be tested under conditions where there is the greatest prospect of success. We systematically reviewed the efficacy of edaravone in animal models of focal ischemia and summarized data using weighted mean difference DerSimonian and Laird random-effects modeling. We used stratified meta-analysis and metaregression to assess the influence of study design and methodological quality. We identified 49 experiments describing outcome in 814 animals; 30 experiments (519 animals) reported functional and 35 experiments ...
http://epubs.surrey.ac.uk/828585/
FDA Accepts Mitsubishi Tanabe Pharmas NDA Filing for Edaravone to Treat ALS | Muscular Dystrophy AssociationFDA Accepts Mitsubishi Tanabe Pharmas NDA Filing for Edaravone to Treat ALS | Muscular Dystrophy Association
Edaravone may be the first ALS treatment approved in U.S. in more than 20 years. As many as 30,000 Americans are estimated to be affected by ALS and more than 5,600 are diagnosed annually.
https://www.mda.org/fda-accepts-mitsubishi-tanabe-pharma%E2%80%99s-nda-filing-edaravone-treat-als
Edaravone | CAS: 89-25-8Edaravone | CAS: 89-25-8
Shenzhen OK Biotech Technology Co., Ltd. (SZOB) yog ib txoj kev Edaravone 89-25-8 chaw tsim khoom thiab tus muag khoom nrog lub Hoobkas, txais tos yuav Edaravone 89-25-8 cov khoom ntawm peb.
http://mww.ok-biotech.com/edaravone-89-25-8
China Powder Api Manufacturers & Suppliers & KilangChina Powder Api Manufacturers & Suppliers & Kilang
Harga Terendah Kualiti API Edaravone CAS No 89-25-8 Formula molekul: C 10 H 10 N 2 O Sinonim: Pemaju CI 1; Radikal; Pemaju CI 1; 1-Phenyl-3-methylpyrazolone-5; Methylphenylpyrazolone; 3H-Pyrazol-3-one, 2, 4-dihydro-5-methyl-2-phenyl-; 2-Pyrazolin-5-one, 3-methyl-1-phenyl-; Edaravone (JAN); 3H-Pyrazol-3-one ...
http://ms.dingminpharma.com/dp-powder-api.html
Buy Edaravone Radicava 20 ml x 10 ampoules for ALS treatment online at sale price from Japan. - Japan Health CenterBuy Edaravone Radicava 20 ml x 10 ampoules for ALS treatment online at sale price from Japan. - Japan Health Center
Edaravone Radicava 20 ml x 10 ampoules (30 mg) ALS cerebral medicine from Japan. Buy online at sale price with worldwide delivery to your address.
https://bio-japan.net/edaravone
Physician Administration of Edaravone | Positions & Initiatives | Policies & Publications | College of Physicians and Surgeons...Physician Administration of Edaravone | Positions & Initiatives | Policies & Publications | College of Physicians and Surgeons...
In keeping with the Colleges mandate to serve and protect the public interest, we recognize the importance of ensuring that patients have safe access to new drug therapies, especially when there are limited treatment options available.
http://www.cpso.on.ca/Policies-Publications/Positions-Initiatives/Physician-Administration-of-Edaravone
Diminazene and antipyrine granules, View Diminazene and antipyrine granules injection, HEXIN Product Details from Hebei Kexing...Diminazene and antipyrine granules, View Diminazene and antipyrine granules injection, HEXIN Product Details from Hebei Kexing...
Diminazene and antipyrine granules,US $ 1.4 - 2 / Box, Antibacterial Drugs, Injection, Granules, Cattle, Fowl, Horse, Sheep.Source from Hebei Kexing Pharmaceutical Co., Ltd. on Alibaba.com.
http://kexingyaoye.en.alibaba.com/product/332301315-209620106/Diminazene_and_antipyrine_granules.html
Patent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google PatentsPatent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google Patents
A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.
http://www.google.com/patents/US5824491?dq=mezick
Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. Effect of lipopolysaccharide on...Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. Effect of lipopolysaccharide on...
Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. Effect of lipopolysaccharide on uterine contractions and prostaglandin production in pregnant rats
http://www.readabstracts.com/Health/Effects-of-antipyrine-on-umbilical-and-regional-metabolism-in-late-gestation-in-the-fetal-lamb.html
1-(3-Chlorophenyl)-3-methyl-2-pyrazolin-5-one (CAS 90-31-3) Market Research Report 20171-(3-Chlorophenyl)-3-methyl-2-pyrazolin-5-one (CAS 90-31-3) Market Research Report 2017
1-(3-Chlorophenyl)-3-methyl-2-pyrazolin-5-one (CAS 90-31-3) Market Research Report 2017 aims at providing comprehensive data on 1-(3-chlorophenyl)-3-methyl-2-pyrazolin-5-one
https://marketpublishers.com/report/industry/chemicals_petrochemicals/1-_3-chlorophenyl_-3-methyl-4_5-dihydro-1h-pyrazol-5-one_90-31-3_market_research_report.html
NIOSHTIC-2 Publications Search - 00188654 - The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether...NIOSHTIC-2 Publications Search - 00188654 - The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether...
The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male Sprague-Dawley-rats were administered 5.1 millimoles per kilogram (mmol/kg) diglyme or 0.1 percent phenobarbital (PB) in their drinking water for 22 days. The effects on hexobarbital sleeping time were evaluated. Other rats were pretreated with 5.1mmol/kg labeled diglyme or 0.
https://www.cdc.gov/niosh/nioshtic-2/00188654.html
4-Acetylaminoantipyrine4-Acetylaminoantipyrine
Other names: Acetamide, N-antipyrinyl-; Acetamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-; Acetamidoantipyrine; Acetyl-4-aminoantipyrine; Acetylaminoantipyrine; Acetylated 4-aminoantipyrine; Antipyrine, 4-acetamido-; N-Acetyl-4-aminoantipyrine; 4-Acetamidoantipyrine; 4-Acetaminoantipyrine; 4-Acetoaminoantipyrine; 4-Acetylaminophenazone; Aminoantipyrine, N-acetyl-; 4-(N-Acetylamino)antipyrine; NSC 331807; N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)acetamide ...
http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C13H15N3O2/c1-9-12
Management of Pediatric Otitis MediaManagement of Pediatric Otitis Media
Since episodes of AOM frequently are associated with pain, the use of analgesics-especially during the first 24 hours of an episode-are strongly recommended by the AAP/AAFP guidelines. Treatment options to reduce the pain associated with otalgia include acetaminophen, ibuprofen, and antipyrine/benzocaine otic solution.7 Antipyrine/benzocaine otic solution is a prescription product used for its local analgesic properties. After the solution is instilled into the ear canal, relief of ear pain occurs in approximately 30 minutes. This product is for otic use only, and it should not be used if the solution is brown or contains a precipitate. Disposal of the bottle is recommended 6 months after the dropper is placed in the solution.12. Treatment with an antibacterial agent is recommended for children younger than 6 months of age, children aged 6 months to 2 years with a certain diagnosis of AOM, and any child with moderate-to-severe otalgia or a fever of 102.2°F (39°C) or greater. Observation ...
https://www.uspharmacist.com/article/management-of-pediatric-otitis-media
Antipyrine; Benzocaine; U-Polycosanol 410 ear dropsAntipyrine; Benzocaine; U-Polycosanol 410 ear drops
This medicine is for use in the outer ear canal. Follow the directions on the prescription label. Wash hands before and after use. Warm the solution by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. Insert a cotton pledget moistened with medication at the ear opening. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use. Use your medicine at regular intervals. Do not use it more often than directed.. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.. ...
http://wellness.bcbsla.com/RelatedItems/121,81015
Is benzocaine and antipyrine otic solution used for swimmers ear? - Answered by top doctors on HealthTapIs benzocaine and antipyrine otic solution used for swimmers ear? - Answered by top doctors on HealthTap
Ear pain. This is a topical anesthetic used to relieve ear pain in ear infections. Drops are put in the ear canal and a cotton plug is then inserted to keep the medication from dribbling out. It can be used every few hours if needed. Read more... ...
https://www.healthtap.com/user_questions/140697-is-benzocaine-and-antipyrine-otic-solution-used-for-swimmer-s-ear
Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary...Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary...
Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The ...
http://escholarship.lib.okayama-u.ac.jp/en/list/ou_authors/F/6bb019d41ba40a5774506e4da22f6611/item/53674
SAMU MEDIAN CO.,LTD.SAMU MEDIAN CO.,LTD.
samu SULPYRIN injection, an analgesicㆍantipyreticㆍantispasmodic of which main ingredient is Sulpyrin, one of Pyrazolone derivative, shows stronger fever alleviating effect about three times as much as Antipyrine and also has powerful action of analgesic and antiphlogistic ...
http://www.samu.co.kr/ENGLISH/product/view.asp?PK=3&PC=AA&strS=ALL&PrdCode=2026&page=5
4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzenesulph... - Registration Dossier - ECHA4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzenesulph... - Registration Dossier - ECHA
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
https://echa.europa.eu/registration-dossier/-/registered-dossier/7480/4/13
Anesthesia-induced Alterations in Plasma Tracer Concentrations May Have Relevance for Brain Imaging Studies | Anesthesiology |...Anesthesia-induced Alterations in Plasma Tracer Concentrations May Have Relevance for Brain Imaging Studies | Anesthesiology |...
One measure of tissue drug exposure is the area under the arterial plasma concentration-versus -time curve (AUC) for the time during which the concentration of the drug remains above some threshold value. We have previously demonstrated that in dogs anesthetized with isoflurane (1.7 MAC), the AUC0-3minfor antipyrine, a marker of lipophilic drug disposition, more than doubled compared to the same animals while awake. 5 Likewise, when awake dogs were treated with an infusion of phenylephrine in a dose sufficient to double the baseline calculated systemic vascular resistance, the AUC0-3minincreased by 75% relative to placebo-treated awake animals. 6 We discovered that the increased arterial concentrations of this lipophilic marker were due to a relative increase in the proportion of cardiac output not involved in the distribution of drug to peripheral tissues. The nondistributive blood flow acts as a pharmacokinetic shunt. This pharmacokinetic shunt could have significantly increased the amount ...
https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1944443
RADICAVA (Edaravone) dosage, indication, interactions, side effects | EMPR - Renal and Urology NewsRADICAVA (Edaravone) dosage, indication, interactions, side effects | EMPR - Renal and Urology News
RADICAVA (Edaravone) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
http://www.renalandurologynews.com/radicava/drug/34722/
Sensation novel - Free Audio BooksSensation novel - Free Audio Books
Armadale audiobook by Wilkie Collins (1824-1889) The novel has a convoluted plot about two distant cousins both named Allan Armadale. The father of one had murdered the father of the other (the two fathers are also named Allan Armadale). The story starts with a deathbed confession by the murderer in the form of a letter to be given to his baby son when he grows up. Many years are skipped over. The son, mistreated at home, runs away from his mother and stepfather, and takes up a wandering life Read more [...] ...
http://free-audio-books.info/category/sensation-novel/
Clinical implications of changes in hepatic drug metabolism in older people | TCRMClinical implications of changes in hepatic drug metabolism in older people | TCRM
Dove Press is a member of the Open Access Initiative, specializing in peer reviewed Medical Journals. View articlesor submit your research for publishing
https://www.dovepress.com/clinical-implications-of-changes-in-hepatic-drug-metabolism-in-older-p-peer-reviewed-article-TCRM
Quantitative autoradiographic mapping of 5‐HT 3 receptors in the rat CNS using ( 125 I)iodo‐zacopride and ( 3 H)zacopride as...Quantitative autoradiographic mapping of 5‐HT 3 receptors in the rat CNS using ( 125 I)iodo‐zacopride and ( 3 H)zacopride as...
Read Quantitative autoradiographic mapping of 5‐HT 3 receptors in the rat CNS using ( 125 I)iodo‐zacopride and ( 3 H)zacopride as radioligands, Synapse on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/wiley/quantitative-autoradiographic-mapping-of-5-ht-3-receptors-in-the-rat-80DA93NjM4?impressionId=5ecf7b3058e6b&i_medium=docview&i_campaign=references&i_source=references
Query about Radicava/Edaravone injection - Motor Neurone Disease Association ForumQuery about Radicava/Edaravone injection - Motor Neurone Disease Association Forum
The reason I am asking is I am getting two types of response from 2 different Neurologist, One doctor is saying first cycle is 14 days (60 mg) each day and then 14 days gap and after that 10 injection per cycle with 14 days gap in between .. Total 6 cycles ...
https://forum.mndassociation.org/forum/motor-neurone-disease-general-discussion/ask-mnd-connect/925-query-about-radicava-edaravone-injection?9230-Query-about-Radicava-Edaravone-injection=&s=148ccb6b8dafa49cf9316157685a611b&mode=threaded
FDA approves drug to treat ALS - Healthcanal.com : Healthcanal.comFDA approves drug to treat ALS - Healthcanal.com : Healthcanal.com
The FDA approved Radicava (edaravone) to treat patients with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrigs disease.
https://www.healthcanal.com/brain-nerves/als/237499-fda-approves-drug-treat-als.html
People in the Math DepartmentPeople in the Math Department
Applications of Rauzy Induction on the Generic Ergodic Theory of Exchange Transformations. Financial Analyst, TPR Associates, The Woodlands, TX.. 2005: Zheng Meng B.S., M.S. Shanghai University ...
http://www.math.rice.edu/People/Alumni/AlumniGraduate.html
Eryzole - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | caas.rxwiki.comEryzole - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | caas.rxwiki.com
Eryzole - Get up-to-date information on Eryzole side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Eryzole
https://caas.rxwiki.com/eryzole
Veterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.netVeterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.net
Product Name: Veterinary Diminazene Aceturate Antipyrine injection Common Name: Veterinary Diminazene Aceturate Phenazone injection Strength: Diminazene Aceturate 140 mg Antipyrine 750 mg Description: Diminazene Aceturate + Antipyrine ready to use...
https://www.ecplaza.net/products/veterinary-diminazene-aceturate-antipyrine-injection_4001149
Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as...Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as...
As a part of a directed program for development of new active agents, novel heterocyclic derivatives with antipyrine and pyrazolone moieties -incorporated in- have been designed and synthesized. Starting with 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivative 2a,b novel Mannich bases derivatives have been synthesized and biologically evaluated for their anti-inflammatory activity. Furthermore, the activity of such compounds has been tested interestingly as COX-1 and COX-2 inhibitors. Structure elucidation of the synthesized compounds was attained by the use of elemental analysis, IR, 1H NMR, 13C NMR, and Mass spectrometry techniques. Compounds 3b, 3d and 4b represent the high % inhibition values for both COX-1 and COX-2. On the other hand, compound 8 showed little selectivity against COX-2 while compound 10 showed good selectivity against COX-1 only. Structure activity relationship has been discussed and the results were confirmed by molecular docking calculations. ...
https://research.aalto.fi/en/publications/design-synthesis-antiinflammatory-activity-and-molecular-docking-of-potential-novel-antipyrine-and-pyrazolone-analogs-as-cyclooxygenase-enzyme-cox-inhibitors
Dichloralphenazone - DrugBankDichloralphenazone - DrugBank
Dichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension and vascular headaches. It is a US Schedule IV drug and its clinical use is limited.
https://www.drugbank.ca/drugs/DB01495
Edaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment | IOVS | ARVO JournalsEdaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment | IOVS | ARVO Journals
Purpose.: To investigate whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, would be neuroprotective against photoreceptor cell death in a rat model of retinal detachment (RD). Methods.: RD was induced in adult Brown Norway rats by subretinal injection of sodium hyaluronate. Edaravone (3, 5, or 10 mg/kg) or physiologic saline was administered intraperitoneally once a day until death on day 3 or 5. Oxidative stress in the retina was assessed by 4-hydroxynonenal staining or ELISA for protein carbonyl content. Photoreceptor death was assessed by TUNEL and measurement of the outer nuclear layer thickness. Western blot analysis and caspase activity assays were performed. Inflammatory cytokine secretion and inflammatory cell infiltration were evaluated by ELISA and immunostaining, respectively. Results.: RD resulted in increased generation of ROS. Treatment with 5 mg/kg edaravone significantly reduced the ROS level, along with a decrease in TUNEL-positive cells in the ...
http://iovs.arvojournals.org/article.aspx?articleid=2166134
Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta. - Semantic...Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta. - Semantic...
The aim of this study was to develop a pharmacokinetic model to describe the transplacental transfer of drugs, based on the human placental perfusion study. The maternal and fetal sides of human placentas were perfused with salicylic acid together with antipyrine, a passive diffusion marker. The drug concentration in the placental tissue was determined at the end of perfusion. A compartment model consisting of maternal space, fetal intravascular space, and placental tissue was fitted to the observed concentration profiles of salicylic acid in the maternal and fetal effluents. The developed model could adequately explain the concentration profiles of salicylic acid in the effluents with influx clearances from maternal and fetal perfusates to placental tissue of 0.0407 and 0.0813 ml/min/g cotyledon and efflux rate constants from placental tissue to maternal and fetal perfusates (k2 and k3) of 0.0238 and 0.176 min(-1), respectively. The kinetics of antipyrine was adequately described by assuming rapid
https://www.semanticscholar.org/paper/Kinetic-analysis-of-the-transport-of-salicylic-aci-Shintaku-Arima/87e74ddd33b5b2a05c77b25ea7b990c0c2aa1158
Antipyrine; Benzocaine ear solutionAntipyrine; Benzocaine ear solution
This medicine is only for use in the outer ear canal. Do not take by mouth. Follow the directions carefully. Wash hands before and after use. The solution may be warmed by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. After the drops are instilled, remain lying with the affected ear upward for 5 minutes to help the drops stay in the ear canal. A cotton pledget moistened with medicine may be gently inserted at the ear opening for no longer than 5 to 10 minutes to ensure retention. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use.. If using for ear wax removal, your doctor or health care professional will tell you how to use this medicine.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
http://healthlibrary.vanderbilthealth.com/Library/DiseasesConditions/Adult/Pediatrics/121,8
Antipyrine; Benzocaine ear solutionAntipyrine; Benzocaine ear solution
This medicine is only for use in the outer ear canal. Do not take by mouth. Follow the directions carefully. Wash hands before and after use. The solution may be warmed by holding the bottle in the hand for 1 to 2 minutes. Lie with the affected ear facing upward. Fill ear canal with the solution. After the drops are instilled, remain lying with the affected ear upward for 5 minutes to help the drops stay in the ear canal. A cotton pledget moistened with medicine may be gently inserted at the ear opening for no longer than 5 to 10 minutes to ensure retention. Repeat, if necessary, for the opposite ear. Do not touch the tip of the dropper to the ear, fingertips, or other surface. Do not rinse the dropper after use.. If using for ear wax removal, your doctor or health care professional will tell you how to use this medicine.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
http://healthlibrary.munsonhealthcare.org/Library/DiseasesConditions/Adult/Otolaryngology/121,8
5r-35-bisdifluoromethyl-5-hydroxy-2-pyrazolin-1-yl-3-4-methoxyphenoxymethylphenylmethanone - albumin5r-35-bisdifluoromethyl-5-hydroxy-2-pyrazolin-1-yl-3-4-methoxyphenoxymethylphenylmethanone - albumin
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
http://albumin.althotas.com/predictions/5r-35-bisdifluoromethyl-5-hydroxy-2-pyrazolin-1-yl-3-4-methoxyphenoxymethylphenylmethanone-albumin.html
Nursing with a raging ear infectionNursing with a raging ear infection
Hey mommas- I woke up last night with extreme ear pain and what turned out to be a horrible ear infection and possibly ruptured ear drum. I was prescribed augmentin which seems to be deemed safe for breastfeeding moms. I was also given drops to help with pain and drainage called antipyrine benzocaine. I couldnt find much on it other than the usual cya warning to talk to your doc if pregnant or breastfeeding. Anyone use these/know their safety??
http://forums.llli.org/showthread.php?115787-Nursing-with-a-raging-ear-infection&p=1306012
ChemIDplus - 53-35-0 - GNFTWPCIRXSCQF-UJXAPRPESA-N - 6beta-Hydroxycortisol - Similar structures search, synonyms, formulas,...ChemIDplus - 53-35-0 - GNFTWPCIRXSCQF-UJXAPRPESA-N - 6beta-Hydroxycortisol - Similar structures search, synonyms, formulas,...
53-35-0 - GNFTWPCIRXSCQF-UJXAPRPESA-N - 6beta-Hydroxycortisol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/53-35-0
2021 ICD-10-CM Diagnosis Code T39.2X2S: Poisoning by pyrazolone derivatives, intentional self-harm, sequela2021 ICD-10-CM Diagnosis Code T39.2X2S: Poisoning by pyrazolone derivatives, intentional self-harm, sequela
Free, official coding info for 2021 ICD-10-CM T39.2X2S - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
https://www.icd10data.com/ICD10CM/Codes/S00-T88/T36-T50/T39-/T39.2X2S
FDA accepts Application als Drug edaravone - Managedcaremag.comFDA accepts Application als Drug edaravone - Managedcaremag.com
The outcome and statistical analysis were divided to three cohorts: 1) patients having elevated D-dimer degrees, 2) patients having increased D-dimer degrees and age 75 decades or older( and 3) those who received a single dose of their drug. The outcome of the trial were also analyzed in a tiered strategy. In case cohort inch revealed statistically significant data, then the consequences of cohort 2 will be analyzed; nevertheless, if one among those cohorts didnt reveal statistical significance, then the subsequent cohorts could simply be considered exploratory. This design, directed by the FDA, has been intended to recognize specific benefit classes in a report population. Cohort inch didnt reveal statistical value that extended prophylaxis using betrixaban paid off the combination VTE end point as well as enoxaparin (6.9percent versus 8.5 percent; P = 0.054). Cohort 2 revealed a statistical decrease in composite VTEs using betrixaban in comparison to enoxaparin (5.6percent versus 7.1 ...
https://www.managedcaremag.com/news/fda-accepts-application-als-drug-edaravone/
Bio-Therapeutic Cream 1oz/4oz | southbaybeautyBio-Therapeutic Cream 1oz/4oz | southbaybeauty
Rich in collagen and elastin, this powerful liposome based cream moisturizes, firms, and provides antioxidant benefits to skin. Contains gamma linoleic acid (GLA) which serves as to improve barrier functions and provides lipid replacement. It also contains Vitamin E, as an antioxidant and free-radical scavenger. Save $42 on the larger 4oz size !
https://www.southbaybeauty.com/product-page/bio-therapeutic-cream-1oz
Anu RamdasAnu Ramdas
Antipyrine. 2016 ISBN 978-87-93108-63-9 Anu Ramdas; Christian Danielewitz. White City / Black Desert - Black City / White ...
https://en.wikipedia.org/wiki/Anu_Ramdas
PhenazonePhenazone
1911). "Antipyrine". Encyclopædia Britannica (11th ed.). Cambridge University Press. Chisholm, Hugh, ed. (1911). "Antipyrine ... Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. Phenazone ... "Antipyrine drugs and health products". sDrugs.com. One or more of the preceding sentences incorporates text from a publication ... The benzene layer on evaporation deposits the anti-pyrine as a colourless crystalline solid which melts at 113 °C and is ...
https://en.wikipedia.org/wiki/Phenazone
KairineKairine
Fruitnight, J. Henry (1886). "Kairine and Antipyrine". Medical Record. 29 (23): 646-648. Bockmuhl M, Dorzbach E. Antipyretics ...
https://en.wikipedia.org/wiki/Kairine
OvartaciOvartaci
Copenhagen: Antipyrine and Billedkunstskolernes Forlag. p. 227. ISBN 978-87-7945-108-7. v t e v t e. ...
https://en.wikipedia.org/wiki/Ovartaci
John Collins (director)John Collins (director)
Antipyrine, Fire Extinguisher. Collins's early work with ERS was presented at downtown New York City venues such as Nada, Here ... Antipyrine, Fire Extinguisher (Nada, 1991). Shuffle (New York Public Library, 2011), (Prague Quadrennial, 2011) A Sort of Joy ( ...
https://en.wikipedia.org/wiki/John_Collins_(director)
WavenumberWavenumber
Murthy, V. L. R.; Lakshman, S. V. J. (1981). "Electronic absorption spectrum of cobalt antipyrine complex". Solid State ...
https://en.wikipedia.org/wiki/Wavenumber
Tristan Tzara bibliographyTristan Tzara bibliography
La Première Aventure céleste de monsieur Antipyrine (The First Celestial Adventure of Mr. Antipyrine; 1916) with colour wood ... Sur le champ (1937). La Deuxième Aventure céleste de monsieur Antipyrine (1938). Midis gagnés (1939), with drawings by Henri ...
https://en.wikipedia.org/wiki/Tristan_Tzara_bibliography
Wilhelm FilehneWilhelm Filehne
Ueber das Antipyrin, ein neues Antipyreticum, 1884 - On antipyrine, a new antipyretic. Lehrbuch der Arzneimittellehre und ... Ueber das Pyramidon, ein Antipyrinderivat, 1896 - On Pyramidon, an antipyrine derivative. The Search for Anti-Inflammatory ...
https://en.wikipedia.org/wiki/Wilhelm_Filehne
DichloralphenazoneDichloralphenazone
... is a 1:2 mixture of antipyrine with chloral hydrate. In combination with paracetamol and isometheptene, it ...
https://en.wikipedia.org/wiki/Dichloralphenazone
Otitis mediaOtitis media
Topical agents shown to be effective include antipyrine and benzocaine ear drops. Decongestants and antihistamines, either ...
https://en.wikipedia.org/wiki/Otitis_media
MetamizoleMetamizole
... made another derivative called pyramidon which was three times more active than antipyrine. In 1893, a derivative of antipyrine ... Yet later, chemists at Hoechst made a derivative, melubrine (sodium antipyrine aminomethanesulfonate), which was introduced in ... also called antipyrine, which has been called "the 'mother' of all modern antipyretic analgesics." Sales of that drug exploded ...
https://en.wikipedia.org/wiki/Metamizole
CYP3A4CYP3A4
... differential disposition of antipyrine and theophylline in humans". The Journal of Pharmacology and Experimental Therapeutics. ...
https://en.wikipedia.org/wiki/CYP3A4
PyrazolonePyrazolone
... s are amongst the oldest synthetic pharmaceuticals, starting with the introduction of antipyrine (phenazone) in 1880s ...
https://en.wikipedia.org/wiki/Pyrazolone
Ludwig KnorrLudwig Knorr
The synthesis in 1883 of the analgesic drug antipyrine, now called phenazone, was a commercial success. Antipyrine was the ... antipyrine, is not to be changed. (German: Antipyrin bleibt!). In 1885 Knorr married Elisabeth Piloty, the sister of his ...
https://en.wikipedia.org/wiki/Ludwig_Knorr
Thomas Ralph MertonThomas Ralph Merton
He conducted various ink experiments with many different chemical solutions, including potassium permanganate, antipyrine and ...
https://en.wikipedia.org/wiki/Thomas_Ralph_Merton
TriboluminescenceTriboluminescence
Novum Organum W. Clegg, G. Bourhill and I. Sage (April 2002). "Hexakis(antipyrine-O)terbium(III) triiodide at 160 K: ... antipyrine)terbium iodide. It is thought that these materials contain impurities, which make the substance locally asymmetric. ...
https://en.wikipedia.org/wiki/Triboluminescence
BenzocaineBenzocaine
It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax. In the US, products ...
https://en.wikipedia.org/wiki/Benzocaine
Elaine Hamilton-ONealElaine Hamilton-O'Neal
ISBN 0-521-43415-7 "Sims Reed Rare Books, la deuxième aventure céleste de monsieur Antipyrine, by Tristan Tzara". Books. ...
https://en.wikipedia.org/wiki/Elaine_Hamilton-O'Neal
Moscow State University of Fine Chemical TechnologiesMoscow State University of Fine Chemical Technologies
... antipyrine, caffeine, alkaloids and others. In 1938, in MITHT under the leadership of academic A. N. Nesmeyanov (later ...
https://en.wikipedia.org/wiki/Moscow_State_University_of_Fine_Chemical_Technologies
Germain SéeGermain Sée
He conducted extensive studies of various drugs, being an advocate of antipyrine as a general analgesic, and sodium salicylate ...
https://en.wikipedia.org/wiki/Germain_Sée
COX-3COX-3
... was actually discovered in 2002, and been found to be selectively inhibited by paracetamol, phenacetin, antipyrine, ...
https://en.wikipedia.org/wiki/COX-3
Marcel JancoMarcel Janco
Antipyrine, having already created the props for its theatrical production. As early as 1917, Marcel Janco began taking his ...
https://en.wikipedia.org/wiki/Marcel_Janco
AmidrineAmidrine
... as well as antipyrine, a non-steroidal anti-inflammatory drug that works to decrease inflammation. Isometheptene is a ...
https://en.wikipedia.org/wiki/Amidrine
PrimidonePrimidone
... and the other enzyme-inducing anticonvulsants can cut the half-life of antipyrine roughly in half (6.2 ± 1.9 h vs. ...
https://en.wikipedia.org/wiki/Primidone
List of MeSH codes (D03)List of MeSH codes (D03)
... antipyrine MeSH D03.383.129.539.850.777 - phenylbutazone MeSH D03.383.129.539.850.777.640 - oxyphenbutazone MeSH D03.383. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
Bernard FantusBernard Fantus
Acetophenetidin Acetaminosalol Cocaine Heroin Aspirin Aconitine Anaesthesin Antimony potassium tartrate Antipyrine Apomorphine ...
https://en.wikipedia.org/wiki/Bernard_Fantus
Tristan TzaraTristan Tzara
Antipyrine ("The First Heavenly Adventure of Mr. Antipyrine"). Tzara's melody, Vaseline symphonique ("Symphonic Vaseline"), ... The 1916 Monsieur's Antipyrine's Manifesto featured a cosmopolitan appeal: "DADA remains within the framework of European ...
https://en.wikipedia.org/wiki/Tristan_Tzara
AntipyreticAntipyretic
... antipyrine), available in combination with benzocaine as an ear drop in the US. Nabumetone Paracetamol (acetaminophen) ...
https://en.wikipedia.org/wiki/Antipyretic
If You PleaseIf You Please
Antipyrine [The First Celestial Adventure of Mr. Antipyrine], Le Serin muet [The Silent Serin] by Ribemont-Dessaignes, Le ...
https://en.wikipedia.org/wiki/If_You_Please
Antipyrine-Benzocaine Otic: MedlinePlus Drug InformationAntipyrine-Benzocaine Otic: MedlinePlus Drug Information
Antipyrine-Benzocaine Otic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... When antipyrine and benzocaine is used to relieve ear pain, it is usually used every 1 to 2 hours as needed. When antipyrine ... Before using antipyrine and benzocaine otic,. *tell your doctor and pharmacist if you are allergic to antipyrine or benzocaine ... Antipyrine and benzocaine are in a class of medications called analgesics. The combination of antipyrine and benzocaine works ...
https://medlineplus.gov/druginfo/meds/a607073.html
Antipyrine and benzocaine ear drops - WikipediaAntipyrine and benzocaine ear drops - Wikipedia
"ANTIPYRINE WITH BENZOCAINE - OTIC". MedicineNet.com. "Auralgan (Antipyrine, Benzocaine, and Glygerin dehydrated) Drug ... Antipyrine 54 mg Benzocaine 14 mg Glycerin and Hydroxyquinoline Sulfate USP A/B otic drops are effective because antipyrine ... Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. It combines ... In 2008, Auralgan was reformulated to include acetic acid and U-polycosanol 410, in addition to antipyrine and benzocaine. Due ...
https://en.wikipedia.org/wiki/Antipyrine_and_benzocaine_ear_drops
Antipyrine/benzocaine/phenylephrine otic Disease Interactions - Drugs.comAntipyrine/benzocaine/phenylephrine otic Disease Interactions - Drugs.com
Comprehensive disease interaction information for antipyrine/benzocaine/phenylephrine otic. Includes Otic Agents - Perforated ... There are 4 disease interactions with antipyrine / benzocaine / phenylephrine otic:. Major Otic Agents (Includes Antipyrine/ ... antipyrine / benzocaine / phenylephrine otic drug Interactions. There is 1 drug interaction with antipyrine / benzocaine / ... Topical Sympathomimetics (Includes Antipyrine/benzocaine/phenylephrine otic) ↔ Bph. Moderate Potential Hazard, Moderate ...
https://www.drugs.com/disease-interactions/antipyrine-benzocaine-phenylephrine-otic.html
Antipyrine/benzocaine/zinc acetate otic Drug Interactions - Drugs.comAntipyrine/benzocaine/zinc acetate otic Drug Interactions - Drugs.com
View drug interactions with antipyrine/benzocaine/zinc acetate otic. This medication may also interact with certain foods or ... Antipyrine / benzocaine / zinc acetate otic is in the drug class otic anesthetics. Antipyrine / benzocaine / zinc acetate otic ... More about antipyrine/benzocaine/zinc acetate otic. *Antipyrine/benzocaine/zinc acetate otic Side Effects ... Antipyrine / benzocaine / zinc acetate otic disease interactions. There is 1 disease interaction with antipyrine / benzocaine ...
https://www.drugs.com/drug-interactions/antipyrine-benzocaine-zinc-acetate-otic.html
Antipyrine - DrugBankAntipyrine - DrugBank
Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From ... Antipyrine and Benzocaine. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Liquid. Topical. Directrx. 2014-01-01. 2014-12-31. ... Antipyrine and Benzocaine. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Solution. Auricular (otic). Boca Pharmacal, Inc.. ... Acella Antipyrine and Benzocaine Otic. Antipyrine (54 mg/1mL) + Benzocaine (14 mg/1mL). Solution. Auricular (otic). Acella ...
https://www.drugbank.ca/drugs/DB01435
antipyrine and benzocaine otic | Cignaantipyrine and benzocaine otic | Cigna
Benzocaine is a local anesthetic (numbing medicine). Antipyrine and benzocaine otic (for use in the ears) is a combination ... To use the ear drops for ear wax removal, use antipyrine and benzocaine otic 3 times per day for up to 3 days. This will help ... What is the most important information I should know about antipyrine and benzocaine otic?. Medicinal use of this product to ... Antipyrine and benzocaine otic is for use only in your ears. Avoid getting this medicine in your mouth or eyes. If it does get ...
https://www.cigna.com/healthwellness/hw/medications/antipyrine-and-benzocaine-otic-d03627a1
Antipyrine mixture with benzocaine | C20H23N3O3 - PubChemAntipyrine mixture with benzocaine | C20H23N3O3 - PubChem
Antipyrine mixture with benzocaine , C20H23N3O3 , CID 173924 - structure, chemical names, physical and chemical properties, ...
https://pubchem.ncbi.nlm.nih.gov/compound/173924
Antipyrine And Benzocaine (Otic Route) Description and Brand Names - Mayo ClinicAntipyrine And Benzocaine (Otic Route) Description and Brand Names - Mayo Clinic
Antipyrine and benzocaine combination is used in the ear to help relieve the pain, swelling, and congestion of some ear ...
https://www.mayoclinic.org/drugs-supplements/antipyrine-and-benzocaine-otic-route/description/drg-20061442
Patent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google PatentsPatent US5824491 - Dry reagent test strip comprising benzidine dye precursor and antipyrine ... - Google Patents
... and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard ... The nature of the mechanism by which the antipyrine compound acts is not known. Although the antipyrine compound can act as a ... Preferably, the antipyrine compound is an aminoantipyrine, and more preferably 4-aminoantipyrine. The antipyrine compound is ... Also, for purposes of this invention, the term antipyrine compound is meant to include antipyrine and derivatives and salts ...
http://www.google.com/patents/US5824491?dq=mezick
Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Uses, Dosage, Side Effects, Interactions, WarningAuralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Uses, Dosage, Side Effects, Interactions, Warning
Antipyrine, Benzocaine and Glycerin Dehydrated) may treat, side effects, dosage, drug interactions, warnings, patient labeling ... Instill Auralgan (antipyrine, benzocaine and glycerin dehydrated) permitting the solution to run along the wall of the canal ... After: Auralgan (antipyrine, benzocaine and glycerin dehydrated) is useful for drying out the canal or relieving discomfort. ... Auralgan (antipyrine, benzocaine and glycerin dehydrated) does not blanch the tympanic membrane or mask the landmarks and, ...
https://www.rxlist.com/auralgan-drug.htm
Antipyrine pharmaceutical drugs and health productsAntipyrine pharmaceutical drugs and health products
Antipyrine indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information ... Antipyrine. Aspirin. Caffeine AB FE - Camps Antipyrine. Benzalkonium Chloride. Boric Acid. Zinc Sulfate Eye Brite - Lambert Kay ... Antipyrine. Diminazene. Vitamin B12 Ganaseg Plus - Novartis Antipyrine. Peru Balsam. Phenol. Sodium Salicylate. Zinc Oxide ... Antipyrine. Chlorobutanol. Chlorpheniramine Maleate. Phenylephrine Hydrochloride Phenil - Sunways India Antipyrine. Cimicifuga ...
http://drugs-about.com/ing/antipyrine.html
Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGESMicro-/mesoporous carbons for controlled release of antipyrine and indomethacin (Journal Article) | DOE PAGES
Antipyrine and indomethacin loading was 6-78% in these micro-/mesoporous carbons. The signatures in thermogravimetric studies ... We have employed two mesoporous and two microporous carbons for the sustained release of one water-soluble drug (antipyrine) ... Accepted Manuscript: Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin ...
https://www.osti.gov/pages/biblio/1325496-micro-mesoporous-carbons-controlled-release-antipyrine-indomethacin
Antipyrine and benzocaine (Otic route)Antipyrine and benzocaine (Otic route)
Antipyrine and benzocaine combination is used in the ear to help relieve the pain, swelling, and congestion of some ear ... Antipyrine and benzocaine (Otic route). Pronunciation:. an-tee-PYE-reen, BEN-zoe-kane ... Although there is no specific information comparing use of antipyrine and benzocaine in the elderly with use in other age ... The presence of other medical problems may affect the use of antipyrine and benzocaine combination. Make sure you tell your ...
https://www.allinahealth.org/CCS/doc/Thomson%20Detailed%20Drugs/47/600009.htm
Does antipyrine, benzocaine and glycerin interact with other drugs? | Anesthetic Agent - SharecareDoes antipyrine, benzocaine and glycerin interact with other drugs? | Anesthetic Agent - Sharecare
Before using antipyrine, benzocaine and glycerin, tell your doctor about any prescription and over-the-cou ... Before using antipyrine, benzocaine and glycerin, tell your doctor about any prescription and over-the-counter medicines, ... Your doctor will determine whether the benefits of using antipyrine, benzocaine and glycerin outweigh the risks. Also, ask your ...
https://www.sharecare.com/health/anesthetic-drugs/interactions-antipyrine-benzocaine-dehydrated
Antipyrine definition and meaning | Collins English DictionaryAntipyrine definition and meaning | Collins English Dictionary
Antipyrine definition: a drug formerly used to reduce pain and fever . Formula: C 11 H 12 N 2 O , Meaning, pronunciation, ... antipyrine in American. (ˌæntaɪˈpaɪˌrin ; anˌtīpīˈrēnˌ; ˌæntiˈpaɪˌrin ; anˌtēpīˈrēnˌ; ˌæntɪˈpaɪˌrin ; anˌtipīˈrēnˌ; ... antipyrine is in the lower 50% of commonly used words in the Collins dictionary ...
https://www.collinsdictionary.com/dictionary/english/antipyrine
Antipyrine Half-Life and Metabolism | Drug Metabolism & DispositionAntipyrine Half-Life and Metabolism | Drug Metabolism & Disposition
Thank you for sharing this Drug Metabolism & Disposition article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
http://dmd.aspetjournals.org/content/2/4/396.1
Veterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.netVeterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.net
Diminazene Aceturate 140 mg Antipyrine 750 mg Description: Diminazene Aceturate + Antipyrine ready to use... ... Veterinary Diminazene Aceturate Antipyrine injection Common Name: Veterinary Diminazene Aceturate Phenazone injection Strength ...
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4-Sodium methanesulfonate methylamine-antipyrine, CAS Number: 8017-81-04-Sodium methanesulfonate methylamine-antipyrine, CAS Number: 8017-81-0
4-Sodium methanesulfonate methylamine-antipyrine - chemical information, properties, structures, articles, patents and more ... Antipyrine Cas No. 60-80-0. Manufacturer. China. Shandong zhishang Chemical Co., Ltd. has established its own factory with ... Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, (Antipyrinylmethylamino)methanesulfonic acid sodium salt, ( ... 4-Sodium methanesulfonate methylamine-antipyrine, 57904-20-8, 5907-38-0, 68-89-3, 8017-81-0, Alginodia, Algocalmin, Algopyrin, ...
http://www.chemindustry.com/chemicals/03889521.html
Fenfluramine Therapy in Non-insulin-dependent Diabetic Patients: Effects on Body Weight, Glucose Homeostasis, Serum...Fenfluramine Therapy in Non-insulin-dependent Diabetic Patients: Effects on Body Weight, Glucose Homeostasis, Serum...
The effect of fenfluramine on hepatic drug metabolism was assessed by using the antipyrine test. F did not cause significant ... changes in antipyrine metabolism. Fenfluramine therefore seems to be useful as an adjunct to diet and SU therapy in obese non- ...
http://care.diabetesjournals.org/content/4/5/535
Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, CAS Number: 8017-81-0Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, CAS Number: 8017-81-0
Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt - chemical information, properties, structures, articles, patents ... Featured suppliers/resources for Antipyrine, 4-(methylamino)-, monomet... List your site here ... Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt, (Antipyrinylmethylamino)methanesulfonic acid sodium salt, ( ... 4-Sodium methanesulfonate methylamine-antipyrine, 57904-20-8, 5907-38-0, 68-89-3, 8017-81-0, Alginodia, Algocalmin, Algopyrin, ...
http://www.chemindustry.com/chemicals/03889534.html
Veterinary Products Phenazone API Grade High Quality AntipyrineVeterinary Products Phenazone API Grade High Quality Antipyrine
... high quality gearbox of Veterinary Products Phenazone API Grade High Quality Antipyrine can adjust the speed timely, avoiding ... Veterinary Products Phenazone API Grade High Quality Antipyrine can improve the nutrition digestion and absorption, ... Veterinary Products Phenazone API Grade High Quality Antipyrine, dry materials processing, the feed particles with high ... It is a professional manufacturer and exporter who Veterinary Products Phenazone API Grade High Quality Antipyrine upon animal ...
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Antipyrine patents and clinical trials: Drug pipeline profiles for drugs in developmentAntipyrine patents and clinical trials: Drug pipeline profiles for drugs in development
Antipyrine. European Patent Office. 3192791. 2034-09-11. Start Trial. Antipyrine. Japan. WO2016039408. 2034-09-11. Start Trial ... Antipyrine is an investigational drug.. There have been 5 clinical trials for Antipyrine. The most recent clinical trial was a ... Antipyrine. Australia. 2006269422. 2025-07-07. Start Trial. >Drugname. >Country. >Document Number. >Estimated Expiration. > ... Antipyrine. Start Trial. Devices and methods for continuous analyte monitoring. DexCom, Inc. (San Diego, CA) Start Trial. ...
https://www.drugpatentwatch.com/p/drugs-in-development/drugname/Antipyrine
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. | Harvard Catalyst...Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. | Harvard Catalyst...
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. J Pharmacol Exp ... Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. ... Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. ...
https://connects.catalyst.harvard.edu/Profiles/display/995481
Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. | Drug Metabolism &...Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. | Drug Metabolism &...
Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.. J E Sharer and S A ... Thus, antipyrine clearance is indeed a general measure of P450 oxidative capacity, with a slight to moderate weight toward 1A2 ...
http://dmd.aspetjournals.org/content/24/4/487
Is benzocaine and antipyrine otic solution used for swimmers ear? - Answered by top doctors on HealthTapIs benzocaine and antipyrine otic solution used for swimmer's ear? - Answered by top doctors on HealthTap
Is antipyrine-benzocaine ear drop used for tmj? * Could I use antipyrine-benzocaine ear drops in adults, if so, whats the ... Is antipyrine-benzocaine ear drop used for tmj? * Could I use antipyrine-benzocaine ear drops in adults, if so, whats the ... Does antipyrine-benzocaine otic help for swimmers ear? * Can antipyrine and benzocaine solution be used for swimmers ear pain? ... What is antipyrine and benzocaine otic solution, USP used for? * Does antipyrine and benzocaine otic solution have a steroid in ...
https://www.healthtap.com/user_questions/140697-is-benzocaine-and-antipyrine-otic-solution-used-for-swimmer-s-ear
Get PDF - Cholestasis and hepatic drug metabolism. Comparison of metabolic clearance rate of antipyrine in patients with...Get PDF - Cholestasis and hepatic drug metabolism. Comparison of metabolic clearance rate of antipyrine in patients with...
Comparison of metabolic clearance rate of antipyrine in patients with intrahepatic or extrahepatic cholestasis ... The metabolic clearance rate of antipyrine: a good index for the assessment of the hepatic drug-oxidizing function in cirrhotic ... Metabolic clearance rate of antipyrine and hepatic microsomal drug oxidizing enzymes in extrahepatic cholestasis. Liver 1(2): ... Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance ...
https://eurekamag.com/research/042/530/042530184.php
Could antipyrine benzocaine ear drops help cracking and popping in the ears due to fliud ? - Answered by top doctors on...Could antipyrine benzocaine ear drops help cracking and popping in the ears due to fliud ? - Answered by top doctors on...
The antipyrine drops are instilled into the ear canal and only anesthetize the outer side of the ear drum, which would help the ... The antipyrine drops are instilled into the ear canal and only anesthetize the outer side of the ear drum, which would help the ... The antipyrine drops are instilled into the ear canal and only anesthetize the outer side of the ear drum, which would help the ... Could antipyrine benzocaine ear drops help cracking and popping in the ears due to fliud ?. 3 doctors weighed in ...
https://www.healthtap.com/user_questions/1134236-could-antipyrine-benzocaine-ear-drops-help-cracking-and-popping-in-the-ears-due-to-fliud
Antipyrine/Benzocaine/Phenylephrine - patient information, description, dosage and directions.Antipyrine/Benzocaine/Phenylephrine - patient information, description, dosage and directions.
Description of the drug Antipyrine/Benzocaine/Phenylephrine. - patient information, description, dosage and directions. What is ... Antipyrine/Benzocaine/Phenylephrine Generic Name: Antipyrine/Benzocaine/Phenylephrine (an-tee-PYE-reen/BEN-zoe-kane/fen-ill-EF- ... Proper storage of Antipyrine/Benzocaine/Phenylephrine :. Store Antipyrine/Benzocaine/Phenylephrine at room temperature, between ... Do not get Antipyrine/Benzocaine/Phenylephrine in the eyes, nose, or mouth. If you get Antipyrine/Benzocaine/Phenylephrine in ...
http://drugster.info/drug/medicament/1885/
antipyrine and benzocaine Otic - patient information, description, dosage and directions.antipyrine and benzocaine Otic - patient information, description, dosage and directions.
Description of the drug antipyrine and benzocaine Otic. - patient information, description, dosage and directions. What is ... Uses For antipyrine and benzocaine. Antipyrine and benzocaine combination is used in the ear to help relieve the pain, swelling ... Strength Topical Welchol Oral Suspension Xenaderm Ointment antipyrine and benzocaine otic Antipyrine/Benzocaine Antipyrine/ ... Proper Use of antipyrine and benzocaine. You may warm the ear drops to body temperature (37 °C or 98.6 °F) by holding the ...
https://drugster.info/drug/medicament/1880/
Antipyrine Metabolism disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsAntipyrine Metabolism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Sex difference in antipyrine 3-hydroxylation. An in vivo-in vitro correlation of antipyrine metabolism in two rat strains. ( ... MalaCards organs/tissues related to Antipyrine Metabolism:. 41 Liver, Lung, Thyroid, Testes, Kidney, Heart ... MalaCards based summary : Antipyrine Metabolism is related to liver disease and alcoholic liver cirrhosis. An important gene ... Articles related to Antipyrine Metabolism:. (show top 50) (show all 105) #. Title. Authors. Year. ...
https://www.malacards.org/card/antipyrine_metabolism
AuralganAnalgesicDrugsDiminazene DiaceturateMetabolismDerivativesMathias KokholmMonsieur AntipyrinePhenylephrineOtitis mediaDropsBenzocaine combinationPharmaceuticalsIndicationsKunsthal AarhusAurodexGlycerinTrypanosomiasisIntravenouslyAllergicKineticsMiddle ear infectionsInteractionsLiverMedicationSheepPhenazoneAuricularHepaticClinical trialsPregnantSolutionTopicalDiscomfort
Auralgan15
  • In 2008, Auralgan was reformulated to include acetic acid and U-polycosanol 410, in addition to antipyrine and benzocaine. (wikipedia.org)
  • Auralgan (Antipyrine, Benzocaine, and Glygerin dehydrated) Drug information. (wikipedia.org)
  • Auralgan is an otic solution containing antipyrine, benzocaine, and dehydrated glycerin. (rxlist.com)
  • Instill Auralgan (antipyrine, benzocaine and glycerin dehydrated) permitting the solution to run along the wall of the canal until it is filled. (rxlist.com)
  • Then moisten a cotton pledget with Auralgan (antipyrine, benzocaine and glycerin dehydrated) and insert into meatus . (rxlist.com)
  • Instill Auralgan (antipyrine, benzocaine and glycerin dehydrated) three times daily for two or three days to help detach cerumen from wall of canal and facilitate removal. (rxlist.com)
  • Auralgan (antipyrine, benzocaine and glycerin dehydrated) is useful for drying out the canal or relieving discomfort. (rxlist.com)
  • Before and after removal of cerumen, a cotton pledget moistened with Auralgan (antipyrine, benzocaine and glycerin dehydrated) should be inserted into the meatus following instillation. (rxlist.com)
  • Auralgan (antipyrine, benzocaine and glycerin dehydrated) ® Otic Solution, in package containing 10 mL bottle with separate dropper-screw cap attachment (NDC 0046-1000-10). (rxlist.com)
  • It is also not known whether Auralgan (antipyrine, benzocaine and glycerin dehydrated) can cause fetal harm when administered to a pregnant woman, or can affect reproduction capacity. (rxlist.com)
  • Auralgan (antipyrine, benzocaine and glycerin dehydrated) should be given to a pregnant woman only if clearly needed. (rxlist.com)
  • Because many drugs are excreted in human milk, caution should be exercised when Auralgan (antipyrine, benzocaine and glycerin dehydrated) is administered to a nursing woman. (rxlist.com)
  • Auralgan (antipyrine, benzocaine and glycerin dehydrated) combines the hygroscopic property of dehydrated glycerin with the analgesic action of antipyrine and benzocaine to relieve pressure, reduce inflammation and congestion , and alleviate pain and discomfort in acute otitis media . (rxlist.com)
  • Auralgan (antipyrine, benzocaine and glycerin dehydrated) does not blanch the tympanic membrane or mask the landmarks and, therefore, does not distort the otoscopic picture. (rxlist.com)
  • Was given auralgan (benzocaine and antipyrine) for ear infection symptoms. (healthtap.com)
Analgesic6
  • Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes. (drugbank.ca)
  • Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. (drugbank.ca)
  • Antipyrine has the effects of analgesic, antipyretic and anti-inflammatory. (digit-life.com)
  • Antipyrine/Benzocaine/Phenylephrine is an analgesic, anesthetic, and sympathomimetic combination. (drugster.info)
  • Antipyrine is an analgesic that helps to decrease the pain and inflammation. (watsonshealth.com.ph)
  • also known as phenazon , antipyrine ( USAN ), or analgesine ) is an analgesic , a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic . (wikipedia.org)
Drugs6
  • Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (drugbank.ca)
  • Does antipyrine, benzocaine and glycerin interact with other drugs? (sharecare.com)
  • This medication is a combination of two drugs-Benzocaine and Antipyrine. (watsonshealth.com.ph)
  • Although precise biochemical mechanisms underlying pharmacokinetic parameters for these drugs in horses were not determined, it is nonetheless concluded from antipyrine results that horses may have an enhanced ability (compared with humans) to clear drugs from the circulation that are primarily metabolized in the liver by phase I oxidative reactions. (islandscholar.ca)
  • AOAC 968.42-1969, Benzocaine and antipyrine in drugs. (aoacofficialmethod.org)
  • Title:Benzocaine and antipyrine in drugs. (aoacofficialmethod.org)
Diminazene Diaceturate1
  • Diminazene diaceturate is a therapeutic agent in the treatment of trypanosomiasis and babesiosis antipyrine contributes to reduce inflammation and fever which goes along with the infection. (alibaba.com)
Metabolism10
  • The effect of fenfluramine on hepatic drug metabolism was assessed by using the antipyrine test. (diabetesjournals.org)
  • F did not cause significant changes in antipyrine metabolism. (diabetesjournals.org)
  • Antipyrine biotransformation has been used extensively in clinical studies as a marker for general hepatic oxidative or cytochrome P450 (P450)-mediated, metabolism. (aspetjournals.org)
  • Antipyrine Metabolism is related to liver disease and alcoholic liver cirrhosis . (malacards.org)
  • An important gene associated with Antipyrine Metabolism is ALB (Albumin), and among its related pathways/superpathways are Selenium Micronutrient Network and FOXA2 and FOXA3 transcription factor networks . (malacards.org)
  • Impact of dioxins on antipyrine metabolism in firefighters. (malacards.org)
  • Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. (readabstracts.com)
  • Antipyrine may affect fetal blood flow distribution and fetal metabolism. (readabstracts.com)
  • Antipyrine is a drug used to measure blood flow in the umbilical cord and uterus in animal studies of fetal metabolism. (readabstracts.com)
  • Treatment with antipyrine also increased anaerobic, or non-oxygen-requiring, metabolism in the lower limbs. (readabstracts.com)
Derivatives2
  • Knorr is noted for his research in organic chemistry that led to his discovery in 1883 of antipyrine, the first of a series of pyrazolone derivatives that found wide use as antipyretics and analgesics. (britannica.com)
  • As a part of a directed program for development of new active agents, novel heterocyclic derivatives with antipyrine and pyrazolone moieties -incorporated in- have been designed and synthesized. (aalto.fi)
Mathias Kokholm1
  • Antipyrine er et uafhængigt forlag drevet af redaktør/kurator Mathias Kokholm. (kunsthal.dk)
Monsieur Antipyrine4
  • Der forekommer to større trykfejl i Monsieur Antipyrine #4/5 , hvorfor vi har lavet to errata-hæfter med de to bidrag det er gået hårdest ud over. (antipyrine.dk)
  • Monsieur Antipyrine siger pardon. (antipyrine.dk)
  • Monsieur Antipyrine er et tidsskrift, der allerede er ude af sync med fortid, fremtid, nutid, samtid, sommertid og vintertid og befinder sig godt dér, mellem årstiderne og Statstidende. (antipyrine.dk)
  • Antipyrine organiserer seminarer, workshops og udstillinger, driver boghandel i Kunsthal Aarhus og udgiver tidsskriftet Monsieur Antipyrine, der redigeres af kunstner Jørgen Michaelsen, kunsthistoriker Mikkel Bolt og forfatterne Mikkel Thykier og Claus Handberg. (kunsthal.dk)
Phenylephrine11
  • However, no specific interactions with Antipyrine/Benzocaine/Phenylephrine are known at this time. (drugster.info)
  • Ask your health care provider if Antipyrine/Benzocaine/Phenylephrine may interact with other medicines that you take. (drugster.info)
  • Use Antipyrine/Benzocaine/Phenylephrine as directed by your doctor. (drugster.info)
  • Do not get Antipyrine/Benzocaine/Phenylephrine in the eyes, nose, or mouth. (drugster.info)
  • If you get Antipyrine/Benzocaine/Phenylephrine in your eyes, rinse thoroughly with cool water. (drugster.info)
  • Moisten a clean cotton plug with Antipyrine/Benzocaine/Phenylephrine and gently insert into the ear canal to prevent medicine from leaking out. (drugster.info)
  • If you miss a dose of Antipyrine/Benzocaine/Phenylephrine , use it as soon as possible. (drugster.info)
  • Antipyrine/Benzocaine/Phenylephrine may cause harm if it is swallowed. (drugster.info)
  • You will need to discuss the benefits and risks of using Antipyrine/Benzocaine/Phenylephrine while you are pregnant. (drugster.info)
  • It is not known if Antipyrine/Benzocaine/Phenylephrine is found in breast milk. (drugster.info)
  • If you are or will be breast-feeding while you use Antipyrine/Benzocaine/Phenylephrine , check with your doctor. (drugster.info)
Otitis media2
  • Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. (wikipedia.org)
  • Antipyrine / benzocaine / zinc acetate otic is used for Otitis Media . (drugs.com)
Drops6
  • Each 1 ml of A/B otic drops contains: Antipyrine 54 mg Benzocaine 14 mg Glycerin and Hydroxyquinoline Sulfate USP A/B otic drops are effective because antipyrine reduces pain and inflammation and benzocaine numbs the ear. (wikipedia.org)
  • To use the ear drops for ear wax removal , use antipyrine and benzocaine otic 3 times per day for up to 3 days. (cigna.com)
  • The antipyrine drops are instilled into the ear canal and only anesthetize the outer side of the ear drum, which would help the pain of an acute ear infection . (healthtap.com)
  • Could ear drops (antipyrine & benzocaine) be dropped on other wounds/infections for pain relief? (healthtap.com)
  • Could I use antipyrine-benzocaine ear drops in adults, if so, what's the dosage? (healthtap.com)
  • A sterile cotton plug may be moistened with a few drops of antipyrine and benzocaine and gently placed at the ear opening for no longer than 5 to 10 minutes to help keep the medicine from leaking out. (drugster.info)
Benzocaine combination2
  • Antipyrine and benzocaine combination is used in the ear to help relieve the pain, swelling, and congestion of some ear infections. (mayoclinic.org)
  • The presence of other medical problems may affect the use of antipyrine and benzocaine combination. (allinahealth.org)
Pharmaceuticals1
  • It is a professional manufacturer and exporter who Veterinary Products Phenazone API Grade High Quality Antipyrine upon animal pharmaceuticals. (digit-life.com)
Indications1
  • Iminazene Diaceturate and Antipyrine Animal Indications are as follows: prophylactics and treatment of babesia, piroplasmosis and trypanosomiasis in camel, cattle, cats, dogs, goats, horse, sheep and swine. (kexingpharmas.com)
Kunsthal Aarhus1
  • The books can be purchased directly in the Antipyrine Bookstore in Kunsthal Aarhus or be ordered from the publisher's website . (kunsthalaarhus.dk)
Aurodex1
  • Aurodex (Antipyrine / Benzocaine) reported to the FDA by people taking it, and by doctors and pharmacists. (iodine.com)
Glycerin2
  • Before using antipyrine, benzocaine and glycerin, tell your doctor about any prescription and over-the-counter medicines, vitamins and herbs you are taking. (sharecare.com)
  • Your doctor will determine whether the benefits of using antipyrine, benzocaine and glycerin outweigh the risks. (sharecare.com)
Trypanosomiasis1
  • Iminazena Diaceturate dan Antipyrine Indikasi Hewan adalah sebagai berikut: profilaksis dan pengobatan babesia, piroplasmosis dan trypanosomiasis pada unta, sapi, kucing, anjing, kambing, kuda, domba dan babi. (kexingpharma.com)
Intravenously2
  • The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. (islandscholar.ca)
  • Among 11 fetal lambs, six were treated intravenously with antipyrine and five were not. (readabstracts.com)
Allergic4
  • tell your doctor and pharmacist if you are allergic to antipyrine or benzocaine or any other medications. (medlineplus.gov)
  • You should not use this medicine if you are allergic to antipyrine or benzocaine, or if you have a hole in your ear drum (ruptured ear drum). (cigna.com)
  • Tell your doctor if you have ever had any unusual or allergic reaction to antipyrine and benzocaine or any other medicines. (drugster.info)
  • Do not use Antipyrine/ Benzocaine if you are allergic to any ingredient of this drug or to similar medicines, or if your eardrum is perforated. (watsonshealth.com.ph)
Kinetics1
  • Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity. (harvard.edu)
Middle ear infections2
  • Antipyrine and benzocaine otic is used to relieve ear pain and swelling caused by middle ear infections. (medlineplus.gov)
  • No. Benzocaine and antipyrine are used for middle ear infections. (healthtap.com)
Interactions1
  • There are no known drug interactions for antipyrine / benzocaine / zinc acetate otic - however, this does not necessarily mean no interactions exist. (drugs.com)
Liver2
  • We have developed a sensitive method for the measurement of antipyrine metabolites formed in the in vitro incubations and applied it to determine the P450s participating in the formation of each metabolite in human liver microsomes. (aspetjournals.org)
  • The plasma disappearance rate of antipyrine in 18 patients with extrahepatic cholestasis and 11 patients with intrahepatic cholestasis was compared with that of two groups of control subjects without liver disease who were matched for age. (eurekamag.com)
Medication2
  • Antipyrine and benzocaine otic should not be used in place of medication prescribed for you by your doctor. (cigna.com)
  • Antipyrine and benzocaine otic may also be used for purposes not listed in this medication guide. (cigna.com)
Sheep1
Phenazone1
  • Veterinary Products Phenazone API Grade High Quality Antipyrine adopts world-class technology to customize and produce special racks. (digit-life.com)
Auricular2
  • 60429-619 Antipyrine and Benzocaine Auricular (Otic) Solution by Golden State Medical Supply, Inc. (medschat.com)
  • 61786-328 Antipyrine and Benzocaine Auricular (Otic) Solution by Remedyrepack Inc. (medschat.com)
Hepatic5
  • Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. (aspetjournals.org)
  • The antipyrine metabolic clearance rate (MCR) was studied in two groups of patients with similar degrees of cholestasis and hepatic damage, but differing mechanisms of cholestasis. (eurekamag.com)
  • The decrease of antipyrine MCR in patients with intrahepatic cholestasis could be due to a reduced functional parenchymal mass related to some degree of hepatic necrosis. (eurekamag.com)
  • Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function oxidases. (islandscholar.ca)
  • However, antipyrine clearance was 10 times greater in horses (5.83 +/- 2.21 ml/min/kg) than in humans (0.536 +/- 0.110 ml/min/kg), which may reflect enhanced hepatic microsomal activity in horses. (islandscholar.ca)
Clinical trials1
Pregnant1
  • If you become pregnant while using antipyrine and benzocaine otic, call your doctor. (medlineplus.gov)
Solution3
  • Antipyrine and benzocaine otic comes as a solution (liquid) to place into the ear. (medlineplus.gov)
  • Is benzocaine and antipyrine otic solution used for swimmer's ear? (healthtap.com)
  • Can antipyrine and benzocaine solution be used for swimmer's ear pain? (healthtap.com)
Topical1
  • 61786-140 Antipyrine and Benzocaine Topical Liquid by Remedyrepack Inc. (medschat.com)
Discomfort1
  • The combination of antipyrine and benzocaine works by reducing pain and discomfort in the ear. (medlineplus.gov)
Antipyrine And Benzocaine (Otic Route) Description and Brand Names - Mayo Clinic
Antipyrine And Benzocaine (Otic Route) Description and Brand Names - Mayo Clinic (mayoclinic.org)
1000 USP Chemicals
1000 USP Chemicals (spectrumchemical.com)
Pharmaceutical Bulk Chemicals | Bulk Fine Chemicals | Spectrum Chemical
Pharmaceutical Bulk Chemicals | Bulk Fine Chemicals | Spectrum Chemical (spectrumchemical.com)
Chemical APIs | Active Pharmaceutical Ingredients | Spectrum Chemical
Chemical APIs | Active Pharmaceutical Ingredients | Spectrum Chemical (spectrumchemical.com)
CFR - Code of Federal Regulations Title 21
CFR - Code of Federal Regulations Title 21 (accessdata.fda.gov)
Zocor - NPS MedicineWise
Zocor - NPS MedicineWise (nps.org.au)
Complete Guide to Prescription & Nonprescription Drugs 2011 - H. Winter Griffith - Google Books
Complete Guide to Prescription & Nonprescription Drugs 2011 - H. Winter Griffith - Google Books (books.google.com)
DailyMed - LEVOCETIRIZINE DIHYDROCHLORIDE solution
DailyMed - LEVOCETIRIZINE DIHYDROCHLORIDE solution (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use LEVOCETIRIZINE DIHYDROCHLORIDE TABLETS safely and effectively...
These highlights do not include all the information needed to use LEVOCETIRIZINE DIHYDROCHLORIDE TABLETS safely and effectively... (dailymed.nlm.nih.gov)
Veterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.net
Veterinary Diminazene Aceturate Antipyrine Injection - Zuche Pharmaceuticals Pvt Ltd - ecplaza.net (ecplaza.net)
Antipyrine-Benzocaine Otic: MedlinePlus Drug Information
Antipyrine-Benzocaine Otic: MedlinePlus Drug Information (medlineplus.gov)
Otozin - FDA prescribing information, side effects and uses
Otozin - FDA prescribing information, side effects and uses (drugs.com)
Reviews in Inorganic Chemistry Volume 28 Issue 1
Reviews in Inorganic Chemistry Volume 28 Issue 1 (degruyter.com)
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update | SpringerLink
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update | SpringerLink (link.springer.com)
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Antipyrine/Benzocaine - Accidently put in eye - what do I do? (drugs.com)
Ludwig Knorr | German chemist | Britannica.com
Ludwig Knorr | German chemist | Britannica.com (britannica.com)
These highlights do not include all the information needed to use QUETIAPINE FUMARATE EXTENDED-RELEASE TABLETS safely and...
These highlights do not include all the information needed to use QUETIAPINE FUMARATE EXTENDED-RELEASE TABLETS safely and... (dailymed.nlm.nih.gov)
Quetiapine Fumarate Full Prescribing Information | HealthyPlace
Quetiapine Fumarate Full Prescribing Information | HealthyPlace (healthyplace.com)
Propranolol tablets
Propranolol tablets (nationwidechildrens.org)
Heterocyclic Communications
Heterocyclic Communications (degruyter.com)
Category:Images from the 1911 Encyclopædia Britannica, volume 2 - Wikimedia Commons
Category:Images from the 1911 Encyclopædia Britannica, volume 2 - Wikimedia Commons (commons.wikimedia.org)
Atorvastatin - FDA prescribing information, side effects and uses
Atorvastatin - FDA prescribing information, side effects and uses (drugs.com)
Treatment of Tuberculosis American Thoracic Society, CDC, and Infectious Diseases Society of America
Treatment of Tuberculosis American Thoracic Society, CDC, and Infectious Diseases Society of America (cdc.gov)
December 1997 - Volume 19 - Issue 6 : Therapeutic Drug Monitoring
December 1997 - Volume 19 - Issue 6 : Therapeutic Drug Monitoring (journals.lww.com)
Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism - 1st Edition
Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism - 1st Edition (elsevier.com)
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Kutane Arzneimittelreaktionen | SpringerLink (link.springer.com)
Auralgan (Antipyrine, Benzocaine and Glycerin Dehydrated): Uses, Dosage, Side Effects, Interactions, Warning
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Pravachol (pravastatin) for High Cholesterol Management: Uses, Dosage, Side Effects, Interactions, Warnings
Pravachol (pravastatin) for High Cholesterol Management: Uses, Dosage, Side Effects, Interactions, Warnings (rxlist.com)
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Pravachol - FDA prescribing information, side effects and uses (drugs.com)
4 Generic Discount Drug Programs | NeedyMeds
4 Generic Discount Drug Programs | NeedyMeds (needymeds.org)
Check Ingredients before Using Prescription Ear Drops on Children - HealthyChildren.org
Check Ingredients before Using Prescription Ear Drops on Children - HealthyChildren.org (healthychildren.org)
Advicor - Uses, Side Effects, Interactions - MedBroadcast.com
Advicor - Uses, Side Effects, Interactions - MedBroadcast.com (medbroadcast.com)
Lean Body Mass as a Predictor of Drug Dosage | SpringerLink
Lean Body Mass as a Predictor of Drug Dosage | SpringerLink (link.springer.com)