Agents, usually topical, that relieve itching (pruritus).
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
A plant genus of the family FABACEAE that is the source of mucuna gum.
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)
Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.
A recurrent contact dermatitis caused by substances found in the work place.
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
A potent mast cell degranulator. It is involved in histamine release.
Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.
The dried seeds, bark, root, stems, buds, leaves, or fruit of aromatic plants used to season food.
The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES.
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
A subgroup of TRP cation channels named after vanilloid receptor. They are very sensitive to TEMPERATURE and hot spicy food and CAPSAICIN. They have the TRP domain and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Drugs considered essential to meet the health needs of a population as well as to control drug costs.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Nonexpendable items used in examination.
A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The area of a nation's economy that is tax-supported and under government control.

The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs. (1/125)

The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity.  (+info)

An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception. (2/125)

BACKGROUND: The most common side effect of spinal opioid administration is pruritus, which has been treated with a variety of agents with variable success. Currently, there are few animal models developed to study this side effect. The aim of this study was to establish a nonhuman primate model to pharmacologically characterize the effects of intrathecal administration of morphine. METHODS: Eight adult rhesus monkeys were used. Scratching responses were videotaped and counted by observers who were blinded to experimental conditions. Antinociception was measured by a warm-water (50 degrees C) tail-withdrawal assay. The dose-response of intrathecal morphine (1-320 microg) for both scratching and antinociception in all subjects was established. An opioid antagonist, nalmefene, was administered either intravenously or subcutaneously to assess its efficacy against intrathecal morphine. RESULTS: Intrathecal morphine (1-32 microg) increased scratching in a dose-dependent manner. Higher doses of intrathecal morphine (10-100 microg) produced thermal antinociception in a dose-dependent manner. On the other hand, nalmefene (10-32 microg/kg intravenously) attenuated maximum scratching responses among subjects. Pretreatment with nalmefene (32 microg/kg subcutaneously) produced approximately 10-fold rightward shifts of intrathecal morphine dose-response curves for both behavioral effects. CONCLUSIONS: These data indicate that intrathecal morphine-induced scratching and antinociception are mediated by opioid receptors. The magnitude of nalmefene antagonism of intrathecal morphine is consistent with microL opioid receptor mediation. This experimental itch model is useful for evaluating different agents that may suppress scratching without interfering with antinociception. It may also facilitate the clarification of mechanisms underlying these phenomena.  (+info)

Interaction of trimeprazine with cyclodextrins in aqueous solution. (3/125)

The synergistic effect of pH and complexation with cyclodextrins on some properties of phenothiazine derivative--trimeprazine (TM) was investigated. Inclusion complexes of TM with beta-cyclodextrin (beta-CD) and its substituted derivatives (DM-beta-CD, HP-beta-CD, beta-CDsulf) were obtained in phosphate buffer solution of different pH (6.8; 5.9; 5.0) using spectral and phase solubility methods Irrespective of the method of determination the apparent stability constant of TM-beta-CD system was the greatest and, in the case of the spectral method, its value increased with decreasing pH. The results obtained by the method of solubility diagrams indicate that increase in solubility of the basic form of TM, following decrease of pH, resulted rather from its transformation to a better soluble, protonated form than its inclusion into CD cavity. The thermodynamic parameters estimated from linear Van't Hoff plot suggest that the van der Waals forces were operating in the TM-beta-CD system. The effect of pH and the presence of cyclodextrins on photostability of TM was also investigated. The photochemical decomposition of TM in the absence and in the presence of CD proceeds according to the first order reaction. The charged form of TM was more stable than free base of this drug and hence the stability of TM increases first of all as result of a decrease in pH and then owing to the presence of CD. The data of 13C NMR analysis indicate that the aromatic portion of TM molecule tends to the interior of CD.  (+info)

Possible estuary-associated syndrome: symptoms, vision, and treatment. (4/125)

The human illness designated as possible estuarine-associated syndrome (PEAS) by the Centers for Disease Control and Prevention (CDC) has been associated with exposure to estuaries inhabited by toxin-forming dinoflagellates, including members of the fish-killing toxic Pfiesteria complex (TPC), Pfiesteria piscicida and Pfiesteria shumwayae. Humans may be exposed through direct contact with estuarine water or by inhalation of aerosolized or volatilized toxin(s). The five cases reported here demonstrate the full spectrum of symptoms experienced during acute and chronic stages of this suspected neurotoxin-mediated illness. The nonspecific symptoms most commonly reported are cough, secretory diarrhea, headache, fatigue, memory impairment, rash, difficulty in concentrating, light sensitivity, burning skin upon water contact, muscle ache, and abdominal pain. Less frequently encountered symptoms are upper airway obstruction, shortness of breath, confusion, red or tearing eyes, weakness, and vertigo. Some patients experience as few as four of these symptoms. The discovery that an indicator of visual pattern-detection ability, visual contrast sensitivity (VCS), is sharply reduced in affected individuals has provided an objective indicator that is useful in diagnosing and monitoring PEAS. VCS deficits are present in both acute and chronic PEAS, and VCS recovers during cholestyramine treatment coincident with symptom abatement. Although PEAS cannot yet be definitively associated with TPC exposure, resolution with cholestyramine treatment suggests a neurotoxin-mediated illness.  (+info)

Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea. (5/125)

1. The cornea of human subjects and of anaesthetised cats was stimulated with a jet of air of controlled flow, temperature and CO(2) concentration delivered by a gas aesthesiometer. 2. In humans, the intensity and magnitude of various components of the sensory experience (intensity of the sensation, degree of irritation, magnitude of burning and stinging pain, magnitude of the cold and warm components of the sensation) were measured using separate visual analog scales. In anaesthetised cats, the impulse response to the same stimuli was recorded from single mechanosensory, polymodal and cold-sensitive corneal fibres in the ciliary nerves. 3. Intensity-response curves for mechanical stimulation showed that all parameters of the sensation experienced by humans increased with the intensity of the stimulus. Mechanical stimuli recruited mainly phasic mechanosensory and polymodal afferents in the cat. 4. Acidic stimulation with gas mixtures of increasing CO(2) concentration evoked irritation, burning and to a lesser extent stinging pain of a magnitude roughly proportional to the intensity of the stimulus in humans. CO(2) primarily recruited polymodal afferents and weakly excited cold-sensitive fibres in the cat's cornea. 5. Heat stimuli evoked in humans a sensation profile similar to CO(2) but accompanied by a warmth component. In the cat's cornea, heat excited only polymodal fibres and silenced cold-sensitive corneal units. 6. Cold stimuli applied to the human cornea elicited a sensation of cooling that became irritant at the lowest temperatures. Corneal cold-sensitive fibres of the cat were activated in a manner proportional to the temperature drop, while polymodal nociceptor fibres were recruited only by the lowest temperatures. Topical menthol (0.2 mM) applied to humans evoked and later eliminated cold sensations produced by cold stimuli while the irritation sensation caused by low temperature stimuli still persisted. 7. Human subjects were able to identify masked mechanical, thermal and chemical stimuli applied to the cornea. 8. Irritation and cold sensations can therefore be evoked separately from the cornea by selective activation of mechanosensory, polymodal and cold corneal sensory afferents. Stimulation with different forms of energy usually leads to combined activation and/or inhibition of the different populations of sensory afferent fibres, evoking blended sensations that include irritation and thermal components in a variable degree.  (+info)

Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice. (6/125)

We previously screened the anti-itching activities of 33 herbal medicines in substance P (SP)-induced itching model mice. One of the most potent antipruritogenic extracts, the methanol extract of fruits of Cnidium monnieri (Cnidii Fructus) was studied further. The chloroform-soluble fraction of the methanol extract markedly inhibited SP-induced scratching. Among 10 subfractions of the chloroform-soluble fraction, the CS-3 fraction had the most potent inhibitory effect on scratching. Each of 3 subfractions of CS-3 showed significant anti-scratching activities. However, inhibitory potencies were not different among the three and weaker than that of CS-3 itself at a same dose. These 3 subfractions of CS-3 mainly contained xanthotoxin, isopimpinellin, bergapten, imperatorin and osthol. Single administration of osthol did not inhibit SP-induced scratching, and imperatorin very weakly subsided scratching. These results suggest that the strong antipruritic action was focused on the CS-3 fraction of the C. monnieri methanol extract, and it might result from the combined effects of these coumarin derivatives, or by undetermined minor compounds.  (+info)

Antipruritic effects of 1,4-naphthoquinones and related compounds. (7/125)

The antipruritic effects of orally administered 1,4-naphthoquinone derivatives and related compounds on compound 48/80-induced scratching behavior in mice were studied. 2-Hydroxy-3-(2-hydroxyethyl)-1,4-naphthoquinone, ferulic acid, 2,2'-methylenebis(3-hydroxy-1,4-naphthoquinone), and 2,2'-ethylidenebis(3-hydroxy-1,4-naphthoquinone) (impatienol) all exhibited significant antipruritic activity. However, 2-methoxy-3-(2-hydroxyethyl)-1,4-naphthoquinone (balsaquinone), which was isolated from a natural source for the first time, did not show any activity. The present results indicate that these compounds are promising for treating allergic diseases with chronic and severe pruritus.  (+info)

Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. (8/125)

There is evidence to suggest that rifampicin is an effective second line therapy for controlling pruritus in patients with chronic cholestatic liver disease. It is most widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). Rifampicin has been reported as causing hepatitis in patients being treated for tuberculosis. Most reports of this have been confounded however by the concurrent use of other hepatotoxic antitubercular therapy. Here we report a single centre experience of the use of rifampicin in PBC, and describe three cases of significant hepatitis associated with rifampicin therapy. Two of these patients had significant impairment of liver synthetic function (necessitating liver transplantation in one case). These are the first reports of impaired hepatic synthetic function due to rifampicin monotherapy. Rifampicin caused significant hepatitis in 7.3% (95% confidence interval 2.5-19.4%) of patients treated for cholestatic liver disease in our centre.  (+info)

TY - JOUR. T1 - Antipruritic effect of curcumin on histamine-induced itching in mice. AU - Lee, Han Kyu. AU - Park, Seok Bum. AU - Chang, Su-Youne. AU - Jung, Sung Jun. PY - 2018/9/1. Y1 - 2018/9/1. N2 - Itching is a common clinical symptom of skin disease that significantly affects a patients quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the ...
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List of elements from ATC D04A: Antipruritics, Topical Use (Antihistamines, Anesthetics) by level of risk according e-lactancia.org
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Essenchi Aquaderm Cream is made from natural plant derivatives which are high in purity, safe and effective. It contains Provitamin B5 which is present in all living tissues and a normal constituent of healthy skin. Essenchi Aquaderm Cream is an excellent skin hydrator, anti-inflammatory and anti-pruritic. It enhances the healing of skin lesions and improves epithelial regeneration. (skin cell and tissue repair)
TY - JOUR. T1 - Five-year malignancy incidence in patients with chronic pruritus. T2 - A population-based cohort study aimed at limiting unnecessary screening practices. AU - Fett, Nicole. AU - Haynes, Kevin. AU - Propert, Kathleen Joy. AU - Margolis, David J.. PY - 2014/4. Y1 - 2014/4. N2 - Background: The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown. Objective: We sought to assess the hazard ratio (HR) of incident overall malignancy and incident malignancy by subtype in patients with chronic pruritus during the 5 years after diagnosis. Methods: A population-based cohort study was performed in the Health Improvement Network. In all, 8744 patients with chronic pruritus were matched with 31,580 patients without chronic pruritus based on sex, age, and practice. Primary outcomes were HR of incident malignancy and HR of malignancy subtypes. Results: The fully adjusted HR for incident malignancy in patients with chronic pruritus was 1.14 (95% confidence ...
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What is hydroxyzine:- Hydroxyzine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of itching, or hives on the skin. Hydroxyzine may be used to treat allergic skin reactions such as hives or contact dermatitis. Since hydroxyzine also reduces activity in the central nervous system, it can be used as a sedative to treat anxiety and tension. It is also used together with other medications given during and after general anesthesia. Hydroxyzine is also used to treat allergic skin reactions such as hives or contact dermatitis. Our Pharmacy Key:- Buy Hydroxyzine Online | Order Hydroxyzine Online | Buy Hydroxyzine Online | Overnight | Fedex | Credit Card | Paypal | COD | Buy Hydroxyzine Online Without Prescription | Buy Hydroxyzine Online With Prescription | Hydroxyzine Overnight Fedex.
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The study was approved by the ethic committee of Songklanagarind Hospital in Songkhla, Thailand, and was designed as a randomized, double-blind, placebo-controlled trial. All patients gave their informed consent after receiving written information of the study. Orthopedic patients were invited to participated between September 2009 and August 2010. Patients were considered eligible if they were aged between 15-70 yr, ASA physical status I-III, and were scheduled for lower limb surgery under spinal anesthesia. Patients were excluded if they presented of any following reasons: contraindication for spinal anesthesia, known allergy history to gabapentin, complaint of pruritus before surgery, morbid obesity (BMI , 35), coexisting skin disorder, and any systemic disease associated with pruritus. Patients who had history of seizure attacks, mental illness, chronic headache, or neuropathic pain and were concomitantly using of anticonvulsants, antidepressants, antipsychotics, or antihistamine were also ...
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Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects. - Mechanism of Action & Protocol.
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Pruritus or itching is an unpleasant sensation that provokes a desire to scratch. Many factors such as chemical, mechanical, thermal and electrical stimuli can elicit the itch sensation. Mediators of itch presumably directly act on nerve fibers or lead to a nerve stimulation cascade whose final common pathway is interpreted in the central nervous system as itching. Putative receptors for itching are C-fibers with exceptionally low conduction velocities and insensitivity to mechanical stimuli. Histamine, the proto-typical chemical mediator of itch, which is released during mast cell degranulation and mediates its effects in the skin via H1 receptor, is the best-known experimental pruritogen.
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced by s.c. injection of various pruritogens in PLCbeta3- or TRPV1-deficient mice. We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. To determine whether the activity of these molecules is represented in a particular subpopulation of sensory neurons, we examined the behavioral consequences of selectively eliminating 2 nonoverlapping subsets of nociceptors. The genetic ablation of MrgprD(+) ...
TY - CHAP. T1 - Pruritus. AU - Weisshaar, Elke. AU - Yosipovitch, Gil. PY - 2014/8/11. Y1 - 2014/8/11. N2 - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures and treatment options.. AB - Pruritus, or itch, is a frequent symptom in dermatology, general practice, and other fields of medicine. Chronic itch usually forms a diagnostic and therapeutic challenge. In the last decade, significant advancement has been achieved in awareness for itch, and new epidemiological studies and treatments have been published. This chapter presents an overview of different forms of common systemic pruritus and their diagnostic measures ...
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Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of colon-innervating sensory neurons in mice express, either individually or in combination, the pruritogenic receptors Tgr5 and the Mas-gene-related GPCRs Mrgpra3 and Mrgprc11. Agonists of these receptors activated subsets of colonic sensory neurons and evoked colonic afferent mechanical hypersensitivity via a TRPA1-dependent mechanism. In vivo intracolonic administration of individual TGR5, MrgprA3, or MrgprC11 agonists induced pronounced visceral hypersensitivity to colorectal distension. Coadministration of these agonists as an itch cocktail augmented hypersensitivity to colorectal distension and changed mouse behavior. These irritant mechanisms were maintained and enhanced in a model of chronic ...
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If your dog spends a large portion of his time scratching, he may have a condition known as pruritus, or itching, an unpleasant sensation that causes your dog to scratch or bite at himself. It is caused by chemical reactions that occur in the skin and stimulate the nerves, causing the brain to feel the itch. In fact, the act of scratching itself may stimulate these inflammatory reactions in the skin and make the condition worse. Any skin condition that causes inflammation can cause pruritus.. How pruritus affects your dogs health depends on the degree of the pruritus. Mild pruritus may hardly have any effect at all. However, severe pruritus leads to intense scratching, which may result in painful skin lesions that may become infected. Your dog will often whimper or cry out and may have trouble sleeping ...
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The present invention provides a peptide having antagonist activity against SP, pain control activity, anti-inflammation activity, and anti-pruritic activity. The present invention further provides a method for searching for a therapeutic agent for pain, a therapeutic agent for inflammation, and a t
Radish, Raphanus sativus is Vitamin C and Copper rich root vegetable support for Antioxidant, Anti-pruritic, Anti-diabetic activity.
This product requires a prescription.Animax is used for dogs and cat. Animax cream or ointment effectively treats skin conditions using 4 kinds of treatment: anti-inflammatory, antipruritic, antifungal and antibacterial.
Description Ref: POAC_TRIT_AEST_001. Common Name: Wheat / Blé / Σιτάρι. Scientific Name: Triticum aestivum. Plants cycle: Annual. Light Requirement: full sun. Soil type: any well drained soil. Cannot tolerate maritime exposure.. Sowing in nursery: -. Direct Planting: Spring or Autumn. Germination: 5 days after sowing. Harvest: 150 days after sowing. Flowers are hermaphrodite (have both male and female organs) Pollination: wind Seed preservation: 5 years. Edible Parts: seeds. Medicine: Antibilious; Antihydrotic; Antipruritic; Antipyretic; Antivinous; Sedative; Skin; Stomachic. The young stems are used in the treatment of biliousness and intoxication. The ash is used to remove skin blemishes. The fruit is antipyretic and sedative. The seed is said to contain sex hormones and has been used in China to promote female fertility. The plant has anticancer properties.. Other Uses: Used for covering the ground to conserve the nutrients in the soil.. ...
Epi-Soothe Shampoo is soothing, antipruritic and helps hydrate for dry and ithcy skin. It contains SPHERULITES® Microcapsules, an exclusive encapsulation system, in a natural oat-grain derivative, soap-free shampoo. Formulated for soothing, cleansing, and controlling mild itch of dry and sensitive skin for dogs, cats, and horses of any age.
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Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia]
A commonly expressed protein in skin - periostin - can directly activate itch-associated neurons in the skin, according to new research from North Carolina State University.
Symptoms of Brachioradial pruritus including 9 medical symptoms and signs of Brachioradial pruritus, alternative diagnoses, misdiagnosis, and correct diagnosis for Brachioradial pruritus signs or Brachioradial pruritus symptoms.
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Pruritus is a common presenting symptom in primary care medicine that can prove distressing to the patient and frustrating for the treating doctor. Here is a practical approach to the diagnosis of its causes and its management, including a discussion of some less familiar conditions in which pruritus is a feature.. ...
13.3 Anti-inflammatory and antipruritic medicines. *13.4 Medicines affecting skin differentiation and proliferation ...
Topical antipruritics in the form of creams and sprays are often available over-the-counter. Oral anti-itch drugs also exist ... Some plant products have been found to be effective anti-pruritics, others not. Non-chemical remedies include cooling, warming ... Erickson, Stephen; Nahmias, Zachary; Rosman, Ilana S.; Kim, Brian S. (July 2018). "Immunomodulating Agents as Antipruritics". ... is an antipruritic agent available as a cream or lotion, often used to treat scabies. Its mechanism of action remains unknown. ...
Antipruritics - anti-itch drugs Morgellons Potter, Mike. "INVISIBLE ITCHES: Insect and Non-Insect Causes". ENTFACT-58. ...
Effective scabicide, pediculocide and antipruritic. Cure rate 60-88%. 2nd line drug for scabies and is seldom used for ...
It has anticholinergic and antipruritic effects. Astemizole is rapidly absorbed from the gastrointestinal tract and ...
As an antipruritic to reduce itching. As a topical analgesic, it is used to relieve minor aches and pains, such as muscle ...
An experimental method for screening antipruritic agents. British Journal of Dermatology. Volume 75 Issue 3 Page 117 - March ...
It is used as an antipruritic ointment. No oral use is known. Side effects are typical of an old (first-generation) ...
An experimental method for screening antipruritic agents. British Journal of Dermatology. Volume 75 Issue 3 p. 117. March 1963 ...
Antipruritic "Rumex L.". Plants of the World Online. Royal Botanic Gardens, Kew. Retrieved 2019-03-11. Martin, Alexander C. ( ...
... is used orally and topically as an antipruritic. It is used topically to treat skin irritations, such as insect ...
... is a synthetic nonfluorinated corticosteroid; topical corticosteroids have anti-inflammatory, antipruritic, and ...
Phan, NQ; Bernhard, JD; Luger, TA; Ständer, S (October 2010). "Antipruritic treatment with systemic μ-opioid receptor ...
... , like other corticosteroids, possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. For ...
Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica. Toxicological risk assessment of Aristolochia species. ...
... (or neohetramine) is an antihistamine and anticholinergic used as an antipruritic. Zolamine Arminio JJ, Sweet CC ( ...
... is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, ...
... is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by ...
2011). "Anti-inflammatory, antipruritic and mast cell stabilizing activity of Aristolochia indica" (PDF). Iranian Journal of ...
KOR agonists suppress itching, and the selective KOR agonist nalfurafine is used clinically as an antipruritic (anti-itch drug ... "Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity". Proc. Natl. Acad. Sci. U.S.A. ...
It was developed as an antipruritic, and has moderate selectivity for the CB2 subtype, having a CB2 affinity of 18nM, and 32x ... April 2012). "Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent". Bioorganic & Medicinal Chemistry ...
... (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is ...
5) Development of human itch-markers for the screening/profiling new anti-pruritic drugs. Under Lars Arendt-Nielsen's ...
... is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays[when ...
The authors state that nalbuphine is an effective anti-pruritic agent against morphine induced pruritus. The effect may be ...
Caladryl is an anti-pruritic solution known for dermatosis application for minor skin irritations and itching. This acquisition ...
These therapies are aimed at relieving symptoms such as itching with antipruritics (e.g. bile acid sequestrants such as ...
... 's active ingredients include phenol 1.2% (providing antiseptic, locally anaesthetic and antipruritic effects) and ...
Though the plant is considered poisonous, it has beneficial uses as an antiparasitic, antipruritic, and haemostatic treatment. ...
Antipruritic shampoos are intended to provide relief of itching due to conditions such as atopy and other allergies. These ...
Topical antipruritics in the form of creams and sprays are often available over the counter. The active ingredients usually ... Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often associated with ... Mirtazapine, a different type of antidepressant, also has antipruritic effects due to its strong antagonism of the H1 receptor ... or benzocaine in topical creams or lotions Oral antipruritics also exist and are usually prescription drugs. These can be ...
Pruritus or itching is an unpleasant sensation that provokes a desire to scratch. Many factors such as chemical, mechanical, thermal and electrical stimuli can elicit the itch sensation. Mediators of itch presumably directly act on nerve fibers or lead to a nerve stimulation cascade whose final common pathway is interpreted in the central nervous system as itching. Putative receptors for itching are C-fibers with exceptionally low conduction velocities and insensitivity to mechanical stimuli. Histamine, the proto-typical chemical mediator of itch, which is released during mast cell degranulation and mediates its effects in the skin via H1 receptor, is the best-known experimental pruritogen.
The Antipruritic Effect of Phototherapy. Franz J. Legat*. *Department of Dermatology and Venerology, Medical University of Graz ... Topical nalfurafine exhibits anti-inflammatory and anti-pruritic effects in a murine model of AD. J Dermatol Sci. (2016) 84:351 ... The antipruritic effect of phototherapy. Ultraviolet irradiation reaches and affects all structures and cells within the upper ... In addition, a yet unknown UV-induced "soluble anti-pruritic factor" (sAPF) from the skin may reach the peripheral as well as ...
Common antipruritics. Topical antipruritics in the form of creams and sprays are often available over-the-counter. Oral (by- ... Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) that is often ... Disputed and questionable antipruritics. * Calamine lotion (zinc oxide with iron(III) oxide), some say has little if any effect ... on itching [2], although other research indicates it has some antipruritic qualities[3] ...
... entered into an exclusive licensing agreement on certain oral disintegration tablet formulation of antipruritic drug TRK-820 ( ... Toray and 3SBio Reach Exclusive Chinese License Agreement on Antipruritic Agent, TRK-820. ... conventional antipruritic agents including antihistamines cannot fully suppress this itching in many cases. According to the ... entered into an exclusive licensing agreement on certain oral disintegration tablet formulation of antipruritic drug TRK-820 ( ...
Antipruritics, Topical Use (Antihistamines, Anesthetics) by level of risk according e-lactancia.org ... Groups related with ATC D04A: Antipruritics, Topical Use (Antihistamines, Anesthetics). *ATC R06A: Antihistamines for systemic ...
Antipruritic-Astringent. MaxiGuard Zn7 Derm is a protective astringent and counterirritant topical to aid in the management of ...
... antibacterial anticarcinogenic antiemetic antifungal antihistamine antimicrobial antiplatelet antipoisonous antipruritic ...
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ATRAPRO ANTIPRURITIC HYDROGEL drug information & product resources from MPR including dosage information, educational materials ... Indications for ATRAPRO ANTIPRURITIC HYDROGEL:. To manage and relieve the pain, burning and itching associated with various ...
Antipruritic activity in Cavia porcellus (guinea pig) histamine phosphate-induced itching model assessed as increase of total ...
Inhibition of histamine or histamine release can produce an antipruritic effect. ... An Antipruritic Effect involves suppression of an itching sensation caused by histamine stimulation of epidermal nerve endings ... Antipruritic Effect. An Antipruritic Effect involves suppression of an itching sensation caused by histamine stimulation of ... Antipruritic Effect of the Topical Phosphodiesterase 4 Inhibitor E6005 Ameliorates Skin Lesions in a Mouse Atopic Dermatitis ...
... and Ondansetron Plus Dexamethasone as Antiemetic and Antipruritic Therapy in Patients Receiving Intrathecal Morphine ... A comparison of dexamethasone, ondansetron, and dexamethasone plus ondansetron as prophylactic antiemetic and antipruritic ... Comparison of Palonosetron, Dexamethasone, and Palonosetron Plus Dexamethasone as Prophylactic Antiemetic and Antipruritic Drug ... Comparison of the Efficacy of Dexamethasone, Ondansetron, and Ondansetron Plus Dexamethasone as Antiemetic and Antipruritic ...
Treat an array of skin conditions from poison ivy rashes to insect bites with hydrocortisone antipruritic cream. This topical ... Hydrocortisone anti-itch/antipruritic cream, .9 gram foil doses in a standard unit box of 10. ...
Antipruritic effect of curcumin on histamine-induced itching in mice. Han Kyu Lee, Seok Bum Park, Su-Youne Chang, Sung Jun Jung ... Antipruritic effect of curcumin on histamine-induced itching in mice. / Lee, Han Kyu; Park, Seok Bum; Chang, Su-Youne; Jung, ... Lee, HK, Park, SB, Chang, S-Y & Jung, SJ 2018, Antipruritic effect of curcumin on histamine-induced itching in mice, Korean ... Antipruritic effect of curcumin on histamine-induced itching in mice. Korean Journal of Physiology and Pharmacology. 2018 Sep 1 ...
Le menthol est un composé organique covalent fabriqué synthétiquement ou obtenu à partir dhuiles de menthe poivrée ou dautres. La capacité de menthol pour déclencher chimiquement les récepteurs sensibles au froid dans la peau est responsable de la sensation de refroidissement bien connu quelle provoque quand inhalées, mangées, ou appliqués sur la peau. Il convient de noter que le menthol ne cause pas une baisse réelle de la température ...
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthols ability to chemically trigger cold-sensitive receptors in the skin is responsible for the well known cooling sensation that it provokes when inhalated, eaten, or applied to the skin. It should be noted that menthol does not cause an actual drop in temperature ...
n. An antipruritic drug. American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by... ... antipruritic. (redirected from Eurax). Also found in: Thesaurus, Medical, Encyclopedia. an·ti·pru·rit·ic. (ăn′tē-pro͝o-rĭt′ĭk, ... antipruritic - a substance that relieves or prevents itching. local anaesthetic, local anesthetic, topical anaesthetic, topical ...
... ... Oclacitinib (0.4 mg/kg, p.o.) reduced pruritus when given 1, 6, 11 and 16 h prior to the observation period, and the anti- ... Randomized, blinded, placebo-controlled studies were designed to evaluate and compare the anti-pruritic properties of ... and to compare the speed of anti-pruritic effects of oclacitinib against those of prednisolone and dexamethasone. ...
Topical Antihistamines/Antipruritics - good prices, favorable terms of delivery and payment - Medideal.in, Call us +91-8285-187 ... Its always easy to shop for Topical Antihistamines/Antipruritics at Medideal.in because you will get genuine medicines at very ... Topical Antihistamines/Antipruritics Cost Less at http://medideal.in. ...
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Adverse effect of antipruritics NON-BILLABLE Non-Billable Code Non-Billable means the code is not sufficient justification for ... ICD-10-CM Drugs Index References for T49.1X5 - Adverse effect of antipruritics The ICD-10-CM Drugs Index links the below- ... Parent Code: T49.1 - Poisoning by, adverse effect of and underdosing of antipruritics ... adverse effect of antipruritics in more detail. The 7th characters that can be added, and the resulting billable codes, are as ...
5 words related to antipruritic: local anaesthetic, local anesthetic, topical anaesthetic, topical anesthetic, local. What are ... antipruritic. (redirected from anti-pruritic). Also found in: Dictionary, Medical, Encyclopedia.. Related to anti-pruritic: ... Anti-pruritic synonyms, anti-pruritic antonyms - FreeThesaurus.com https://www.freethesaurus.com/anti-pruritic ... Words related to antipruritic. a substance that relieves or prevents itching. Related Words. *local anaesthetic ...
... antipruritic activity of sour orange cream,calamin cream and placebo on 27 volunteers were evaluated during 110 minutes.in this ... and since in Iranian traditional medicine sour orange fruit has been implicated as having antipruritic effects,in this study ... study of antipruritic effect of citrus bigaradia(sour orange). Article 3, Volume 3, Issue 1, November and December 1996, Page ... "study of antipruritic effect of citrus bigaradia(sour orange)". Journal of Kerman University of Medical Sciences, 3, 1, 1996, ...
Antipruritics,, also known as ,anti-itch drugs,, are ,medications, that inhibit the ,itc... World Heritage Encyclopedia, the ... Antipruritic. Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often ... Common antipruritics Topical antipruritics in the form of creams and sprays are often available over the counter. Oral anti- ... Disputed and questionable antipruritics * Burows solution, an astringent aqueous solution of aluminium acetate, is shown to ...
Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching that is often associated with sunburns, ... antipruritic meds atrapro hydrogel side effects medications cream drug list benadryl type means antipruritics also known anti ... Antipruritic. Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching that is often associated ... TRANSLATION OF ANTIPRURITIC Find out the translation of antipruritic to 25 languages with our English multilingual translator. ...
Sugimoto Y, Nakamura Y, Hossen MA, Watanabe T, Kamei C. Evaluation of the effects of anti-pruritic drugs on scratch responses ... The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H1 ... Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice. In: European ... Sugimoto, Y., Nakamura, Y., Hossen, M. A., Watanabe, T., & Kamei, C. (2003). Evaluation of the effects of anti-pruritic drugs ...
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PRUZAX ULTRA is an antipruritic cream (face / body) effective in the symptomatic / temporary relief of pruritus (itch) of any ... PRUZAX Ultra Cream 150ml Antipruritic cream (face / body). Description PRUZAX ULTRA is an antipruritic cream (face / body) ... a) Antipruritic. b) Moisturizing. c) Mild antiflammatory. PRUZAX ULTRA cream also restores the normal epidermal barrier ... The antipruritic action of a polidocanol-urea containing topical preparation was demonstrated in a resent Observational Study, ...
Anti-pruritic (anti-itch) preparations. *Application of topical anti-pruritic (anti-itching) lotions and creams, such as ...
  • The active ingredients usually belong to these classes: Antihistamines such as diphenhydramine (Benadryl) and Hydroxyzine Corticosteroids such as hydrocortisone topical cream, see topical steroid Counterirritants, such as mint oil, menthol, or camphor Local anesthetics such as lidocaine, pramoxine, or benzocaine in topical creams or lotions Oral antipruritics also exist and are usually prescription drugs. (wikipedia.org)
  • Also, histamine, a generally known substance for causing itching, is known to have less involvement with the itching, and therefore, conventional antipruritic agents including antihistamines cannot fully suppress this itching in many cases. (webwire.com)
  • ATC D04A: Antipruritics, Topical Use (Antihistamines, Anesthetics) and breastfeeding. (e-lactancia.org)
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  • When looking at the broad antipruritic effect of phototherapy the question arises how phototherapy is capable of reducing pruritus in such a variety of inflammatory skin and systemic diseases with obviously very different pathophysiological backgrounds? (frontiersin.org)
  • It is clear, that the antipruritic effect of phototherapy has to depend on the ability of UV light to interfere with structures and mediators involved in the induction and perception of pruritus. (frontiersin.org)
  • PRUZAX ULTRA is an antipruritic cream (face / body) effective in the symptomatic / temporary relief of pruritus (itch) of any cause (associated with dermatological, systemic or paediatric diseases, as well as drug-induced pruritus). (pharmacy4u.gr)
  • The antipruritic action of a polidocanol-urea containing topical preparation was demonstrated in a resent Observational Study, conducted in Federal Republic of Germany with the participation of 196 physicians and 910 patients (among them were 25 children 0-6 years old and 34 children 6-12 years old) with Atopic Dermatitis (36% of the patients), Pruritus Senilis (24% of the patients) and other itchy skin conditions. (pharmacy4u.gr)
  • These results suggest that acupuncture and EA stimulation are effective treatments for pruritus if administered to dermatomes corresponding to affected sites or to adjacent dermatomes and that this effect is due to the antipruritic effect of κ-opioid receptor activation maximally induced by high-frequency EA stimulation. (elsevier.com)
  • We evaluated the antipruritic effects of Neurotropin injections in patients with moisturizer- and antihistamine-resistant pruritus. (shimane-u.ac.jp)
  • Observations on the Antipruritic Effect of Guanethidine in Atopic Dermatitis. (semanticscholar.org)
  • As a potent H1 and H2 antagonist, the antipruritic effect of topical doxepin has been demonstrated in eczematous dermatitis. (elsevier.com)
  • Susceptible skin and ear infections requiring antibacterial, antifungal, anti-inflammatory and antipruritic effects in dogs and cats. (petceutics.com.au)
  • The exclusive Temaril-P formula combines the antipruritic and antitussive action of trimeprazine with the anti-inflammatory action of prednisolone. (drugs.com)
  • It has anti-inflammatory, antipruritic, and vasoconstrictive properties. (medscape.com)
  • Doxepin is in a class of medications called topical antipruritics. (medlineplus.gov)
  • The child was treated with antipyretic and antipruritic medications and discharged. (cdc.gov)
  • An Antipruritic Effect involves suppression of an itching sensation caused by histamine stimulation of epidermal nerve endings. (semanticscholar.org)
  • Treatment consists of topical applications of antipruritics, corticosteroids, and testosterone to the affected areas. (healthcentral.com)
  • Hydrocortisone anti-itch/antipruritic cream, .9 gram foil doses in a standard unit box of 10. (firstaidsuppliesonline.com)
  • B. Kamins Antipruritic Cream helps aid many different cases of dry skin, including eczema, allergic reactions and dermatitis. (drskinspa.com)
  • UV-light may directly affect cutaneous sensory nerve fibers or, via the release of mediators from cells within the skin, indirectly modulate their function as well as the transmission of itch to the central nervous system inducing the clinically recognized antipruritic effect of phototherapy. (frontiersin.org)
  • Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans. (semanticscholar.org)
  • To code a diagnosis of this type, you must use specify a 7th character that describes the diagnosis 'adverse effect of antipruritics' in more detail. (icd.codes)
  • study of antipruritic effect of citrus bigaradia(sour orange)', Journal of Kerman University of Medical Sciences , 3(1), pp. 26-31. (ac.ir)
  • However, it is not known at all that these compounds have an antipruritic effect. (justia.com)
  • As a result, they have found that a nociceptin antagonist has an antipruritic effect. (justia.com)
  • More specifically, they have found that the compound of the general formula (II) of claim 2 has a nociceptin antagonism and also has an antipruritic effect, and that the compounds of the general formulas (I), (III) and (IV) of claim 2 known to have a nociceptin antagonism have an antipruritic effect. (justia.com)
  • The antipruritic effect of acupuncture was studied using a rat model of hindlimb scratching. (elsevier.com)
  • In the second experiment, plain acupuncture, or 2Hz, or 120Hz EA were applied to acupoints LI 11 and LI 4, at which acupuncture stimulation produced the greatest antipruritic effect in the 1st experiment, and as serotonin was administered in the same manner described for the 1st experiment. (elsevier.com)
  • When nor-binaltorphimine (a κ-opioid receptor antagonist) was pretreated to elucidate the relation between κ-opioid receptor and the antipruritic effect of 120Hz EA, it was found to markedly inhibit the antipruritic effect of 120Hz EA. (elsevier.com)
  • With Qi and blood, promoting blood circulation, antipruritic effect. (misfire.us)
  • Mirtazapine, a different type of antidepressant, also has antipruritic effects due to its strong antagonism of the H1 receptor. (wikipedia.org)
  • An object of the present invention is to provide an excellent antipruritic agent having a novel action mechanism and, more particularly, to provide an antipruritic agent having a nociceptin antagonism as the action mechanism. (justia.com)
  • The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. (justia.com)
  • It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. (hormone-peptidelabs.com)
  • Antipruritic Placebo Effects by Conditioning H1-antihistamine. (nih.gov)
  • The present invention relates to an antipruritic agent. (justia.com)
  • Find out the translation of antipruritic to 25 languages with our English multilingual translator . (educalingo.com)
  • Topical antipruritics in the form of creams and sprays are often available over the counter. (wikipedia.org)
  • The term «antipruritic» is normally little used and occupies the 110.001 position in our list of most widely used terms in the English dictionary . (educalingo.com)
  • It has analgesic and antipruritic effects. (imexbb.com)
  • Camphor is used for a long time in creams and ointments as an antiseptic, analgesic and antipruritic. (hemotreat.co.uk)
  • All dermatologicals are readily available in these healthcare specialist retailers, but topical germicidals/antiseptics and antipruritics also can be obtained in more easily accessible channels, such as convenience stores. (euromonitor.com)
  • This may include application of topical antiseptics, corticosteroid creams, and antipruritic lotions that contain menthol. (patientcareonline.com)
  • 2. Antihistamines, antihistamine-containing combinations, and antipruritics. (justia.com)
  • Did this occur within hours of sleep and your child been dry in the urine with little or too much or what might have been proposed for use as antipruritics, topical corticosteroids, antiinfective preparations, and stevens-johnson syndrome was first noted as azotemia. (childbirthsolutions.com)
  • Essential oil to relieve pain and bruises 20ml/bottle sterilized, antipruritic and antibacterial. (trensan.com)
  • The allergy formula may help reduce common environmental allergies and often you will notice a decrease in itching after the very first dose with its strong antipruritic properties. (shintospetfood.com)