Trypanosoma brucei rhodesiense
Pentamidine
Parasitic Sensitivity Tests
Leishmania donovani
Protozoan Infections
Trypanocidal Agents
Mikania
Trypanosoma cruzi
Trypanosoma
Leishmania infantum
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). Human infections are confined almost entirely to children. This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental host. Transmission is by Phlebotomus sandflies.
Inhibitory Concentration 50
Chagas Disease
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Chagas Cardiomyopathy
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Software
Terminology as Topic
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Persistent damage to Enterocytozoon bieneusi, with persistent symptomatic relief, after combined furazolidone and albendazole in AIDS patients. (1/1602)
AIM: To investigate morphological changes in Enterocytozoon bieneusi and the duration of symptomatic relief after combination treatment with furazolidone and albendazole in AIDS patients. METHODS: Four severely immunocompromised AIDS patients with symptomatic E bieneusi infection of the gut received an 18 day course of combined furazolidone and albendazole (500 + 800 mg daily). All patients were monitored for parasite shedding in stool by light microscopy at the end of treatment and monthly during follow up. At the end of treatment, duodenal biopsy specimens obtained from three patients were studied by transmission electron microscopy by two pathologists blind to the patients' treatment or clinical outcome. Duodenal biopsy specimens obtained from one of the patients two months after completion of treatment were also studied electronmicroscopically. RESULTS: All patients had long lasting symptomatic relief, with a major decrease--or transient absence--of spore shedding in stools from completion of treatment. After treatment, changes in faecal spores were persistently found by light microscopy in all cases, and there was evidence of both a substantial decrease in the parasite load and ultrastructural damage in the parasite in all biopsy specimens. The treatment was well tolerated, and no patient had clinical or parasitological relapse during follow up (up to 15 months). CONCLUSIONS: The long lasting symptomatic relief observed in all four treated patients correlated with the persistent decrease in parasite load both in tissue and in stool, and with the morphological changes observed in the life cycle of the protozoan. These data suggest that combined treatment with furazolidone and albendazole is active against E bieneusi and may result in lasting remission even in severely immunocompromised patients. (+info)U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. (2/1602)
In August 1997, AmBisome (liposomal amphotericin B, Nexstar, San Dimas, CA) was the first drug approved for the treatment of visceral leishmaniasis by the U.S. Food and Drug Administration. The growing recognition of emerging and reemerging infections warrants that safe and effective agents to treat such infections be readily available in the United States. The following discussion of the data submitted in support of the New Drug Application for AmBisome for the treatment of visceral leishmaniasis shows the breadth of data from clinical trials that can be appropriate to support approval for drugs to treat tropical diseases. (+info)Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. (3/1602)
Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb. (+info)Value of Western blotting in the clinical follow-up of canine leishmaniasis. (4/1602)
Specific serum antibody levels in Leishmania infantum-infected dogs treated with a combination of glucantime and allopurinol were estimated by indirect immunofluorescence and Western blotting. The sensitivity of Western blot was greater than that obtained with immunofluorescence titration. In general, both diagnostic methods concurred with the post-treatment clinical status of the animals. Clinical improvement of successfully treated dogs was related to lower immunofluorescence titers and simpler and/or less reactive immunodetection patterns in Western blotting. The recognition, by infected dogs, of certain low molecular weight antigens, particularly one of approximately 26 kDa, was restricted to pretreatment samples and a single animal in relapse thus apparently constituting an active infection marker. (+info)Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii. (5/1602)
The activity of recombinant bactericidal/permeability-increasing protein (rBPI21), alone or in combination with sulfadiazine, on the intracellular replication of Toxoplasma gondii was assessed in vitro and in mice with acute toxoplasmosis. rBPI21 markedly inhibited the intracellular growth of T. gondii in human foreskin fibroblasts (HFFs). Following 72 h of exposure, the 50% inhibitory concentration of rBPI21 for T. gondii was 2.6 micrograms/ml, whereas only slight cytotoxicity for HFF cells was observed at the concentrations tested. Subsequent mathematical analyses revealed that the combination of rBPI21 with sulfadiazine yielded slight to moderate synergistic effects against T. gondii in vitro. Infection of mice orally with C56 cysts or intraperitoneally (i.p.) with RH tachyzoites resulted in 100% mortality, whereas prolongation of the time to death or significant survival (P = 0.002) was noted for those animals treated with 5 to 20 mg of rBPI21 per kg of body weight per day. Treatment with rBPI21 in combination with sulfadiazine resulted in significant (P = 0.0001) survival of mice infected i.p. with tachyzoites but not of mice infected orally with T. gondii cysts. These results indicate that rBPI21 is active in vitro and in vivo against T. gondii and that its activity is significantly enhanced when it is used in combination with sulfadiazine. To our knowledge, this is the first report of the activity of rBPI21 against a protozoan parasite. (+info)Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. (6/1602)
A wide variety of biologically active compounds contain indole and quinoline nuclei. Some novel indolylquinoline derivatives were synthesized from indole by Friedel-Crafts acylation reaction. Out of the four derivatives tested, 2-(2''-acetamidobenzyl)-3-(3'-indolylquinoline) (C) had no effect on the promastigotes or amastigotes of Leishmania donovani in vitro. The remaining three analogues, 2-(2''-dichloroacetamidobenzyl)-3-(3'-indolylquinoline) (A), 2-(2''-chloroacetamidobenzyl)-3-(3'-indolylquinoline) (B), and 2-(2''-aminobenzyl)-3-(3'-indolylquinoline) (D), inhibited the growth of L. donovani promastigotes in vitro and were cytotoxic to both the promastigote and amastigote forms of the parasite. These three derivatives were also effective in eliminating L. donovani amastigotes from BALB/c mouse peritoneal macrophages in vitro. One indolylquinoline derivative [A] was used to treat established visceral leishmaniasis in BALB/c mice. This compound was significantly more effective than sodium antimony gluconate (SAG) in reducing the splenic parasite load at a much lower concentration (5% of SAG). Our results suggest that indolylquinoline derivatives may be exploited as antileishmanial agents. (+info)What controls glycolysis in bloodstream form Trypanosoma brucei? (7/1602)
On the basis of the experimentally determined kinetic properties of the trypanosomal enzymes, the question is addressed of which step limits the glycolytic flux in bloodstream form Trypanosoma brucei. There appeared to be no single answer; in the physiological range, control shifted between the glucose transporter on the one hand and aldolase (ALD), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), and glycerol-3-phosphate dehydrogenase (GDH) on the other hand. The other kinases, which are often thought to control glycolysis, exerted little control; so did the utilization of ATP. We identified potential targets for anti-trypanosomal drugs by calculating which steps need the least inhibition to achieve a certain inhibition of the glycolytic flux in these parasites. The glucose transporter appeared to be the most promising target, followed by ALD, GDH, GAPDH, and PGK. By contrast, in erythrocytes more than 95% deficiencies of PGK, GAPDH, or ALD did not cause any clinical symptoms (Schuster, R. and Holzhutter, H.-G. (1995) Eur. J. Biochem. 229, 403-418). Therefore, the selectivity of drugs inhibiting these enzymes may be much higher than expected from their molecular effects alone. Quite unexpectedly, trypanosomes seem to possess a substantial overcapacity of hexokinase, phosphofructokinase, and pyruvate kinase, making these "irreversible" enzymes mediocre drug targets. (+info)Cost-effectiveness analysis of humanitarian relief interventions: visceral leishmaniasis treatment in the Sudan. (8/1602)
Spending by aid agencies on emergencies has quadrupled over the last decade, to over US$6 billion. To date, cost-effectiveness has seldom been considered in the prioritization and evaluation of emergency interventions. The sheer volume of resources spent on humanitarian aid and the chronicity of many humanitarian interventions call for more attention to be paid to the issue of 'value for money'. In this paper we present data from a major humanitarian crisis, an epidemic of visceral leishmaniasis (VL) in war-torn Sudan. The special circumstances provided us, in retrospect, with unusually accurate data on excess mortality, costs of the intervention and its effects, thus allowing us to express cost-effectiveness as the cost per Disability Adjusted Life Year (DALY) averted. The cost-effectiveness ratio, of US$18.40 per DALY (uncertainty range between US$13.53 and US$27.63), places the treatment of VL in Sudan among health interventions considered 'very good value for money' (interventions of less than US$25 per DALY). We discuss the usefulness of this analysis to the internal management of the VL programme, the procurement of funds for the programme, and more generally, to priority setting in humanitarian relief interventions. We feel that in evaluations of emergency interventions attempts could be made more often to perform cost-effectiveness analyses, including the use of DALYs, provided that the outcomes of these analyses are seen in the broad context of the emergency situation and its consequences on the affected population. This paper provides a first contribution to what is hoped to become an international database of cost-effectiveness studies of health interventions during relief operations, which use a comparable measure of health outcome such as the DALY. (+info)
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Antiprotozoal
As a result, agents effective against one pathogen may not be effective against another. Antiprotozoal agents can be grouped by ... "Antiprotozoal Agents: An Overview". Anti-Infective Agents in Medicinal Chemistry. 8 (4): 345-366. doi:10.2174/ ... Antiprotozoal agents, Biocides, All stub articles, Antiinfective agent stubs). ... Antiprotozoal agents (ATC code: ATC P01) is a class of pharmaceuticals used in treatment of protozoan infection. A paraphyletic ...
Chiniofon
Antiprotozoal agents, All stub articles, Antiinfective agent stubs). ... Chiniofon is an antiprotozoal agent. "Chiniofon". WHO Collaborating Centre for Drug Statistics Methodology. Leake CD (December ...
Difetarsone
Antiprotozoal agents, Arsonic acids, All stub articles, Antiinfective agent stubs). ... Difetarsone is an antiprotozoal agent. Various studies have shown it to be particularly effective against Trichuris trichiura, ...
Teclozan
Antiprotozoal agents, Acetamides, Ethers, All stub articles, Antiinfective agent stubs). ... Teclozan is an antiprotozoal agent. It is a dichloroacetamide. Slighter RG, Yarinsky A, Drobeck HP, Bailey DM (August 1980). " ... "Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal ...
Broxyquinoline
Antiprotozoal agents, All stub articles, Gastrointestinal system drug stubs, Antiinfective agent stubs). ... Broxyquinoline is an antiprotozoal agent. An association with exercise intolerance has been reported. Swain R, Bapna JS ( ...
Arsthinol
... (INN) is an antiprotozoal agent. It was synthesized for the first time in 1949 by Ernst A.H. Friedheim by ... Antiprotozoal agents, Acetanilides, Primary alcohols, Phenols, Organoarsenic dithiolates, Arsenic heterocycles, Arsenic(III) ... compounds, Sulfur heterocycles, Heterocyclic compounds with 1 ring, All stub articles, Antiinfective agent stubs). ...
Tilbroquinol
Antiprotozoal agents, Bromoarenes, Quinolinols, All stub articles, Antiinfective agent stubs). ... Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has also been used against Vibrio cholerae. ...
Albaconazole
It has also been studied as an antiprotozoal agent. "Albaconazole". Adis Insight. Springer Nature Switzerland AG. Guedes PM, ... Antimicrobial Agents and Chemotherapy. 48 (11): 4286-92. doi:10.1128/AAC.48.11.4286-4292.2004. PMC 525424. PMID 15504854. v t e ...
Infection
... including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of infection, the antibiotic may be ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...
Coccidiostat
MeSH list of agents 82003049 v t e (Antiprotozoal agents, All stub articles, Antiinfective agent stubs). ... A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. Examples include: Amprolium Arprinocid Artemether ...
Antitrichomonal agent
MeSH list of agents 82000994 v t e (Antiprotozoal agents, All stub articles, Antiinfective agent stubs). ... An antitrichomonal agent is an antiprotozoal agent that acts on trichomonas parasites. Examples include: furazolidone nifuratel ... nimorazole ornidazole tinidazole usnic acid Antitrichomonal+Agents at the US National Library of Medicine Medical Subject ...
Trypanocidal agent
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: Aminoquinuride ... Antiprotozoal agents, All stub articles, Antiinfective agent stubs). ... Trypanosomiasis vaccine Trypanocidal+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of ... agents 82014344 GOBLE, F. C. (January 1950). "Chemotherapy of experimental trypanosomiasis; trypanocidal activity of certain ...
Maduramicin
... (maduramycin) is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis. It is a natural ... Antiprotozoal agents, Carboxylic acids, Secondary alcohols, Spiro compounds, Tertiary alcohols, Tetrahydrofurans, ... Tetrahydropyrans, All stub articles, Antiinfective agent stubs). ...
Phanquinone
Antiprotozoal agents, Phenanthrolines, Quinones, Bipyridines, Enones, All stub articles, Antiinfective agent stubs). ... It has been investigated as both antiprotozoal agent and for its bactericidal activity . Mett H, Gyr K, Zak O, Vosbeck K (July ... Agents Chemother. 26 (1): 35-8. doi:10.1128/aac.26.1.35. PMC 179912. PMID 6236746. v t e (Articles with changed CASNo ...
Nifuratel
It is a local antiprotozoal and antifungal agent that may also be given orally. Nifuratel is not approved for use in the United ...
Pentavalent antimonial
v t e (Antiprotozoal agents, Antimony(V) compounds, All stub articles, Antiinfective agent stubs). ...
Mepacrine
The main uses of mepacrine are as an antiprotozoal, antirheumatic, and an intrapleural sclerosing agent. Antiprotozoal use ... Antiprotozoal agents, Antimalarial agents, Sterilization (medicine), Experimental methods of birth control, Acridines, ... This antiprotozoal is also approved for the treatment of giardiasis (an intestinal parasite), and has been researched as an ... Agents Chemother. 55 (5): 1827-1830. doi:10.1128/aac.01296-10. PMC 3088196. PMID 21383088. Canete R, Escobedo AA, Gonzalez ME, ...
Tritrichomonas blagburni
However, antiprotozoal agents, such as ronidazole or metronidazole, are known to dramatically reduce symptoms in cats. Research ... "New species of parasite discovered as disease agent in domestic cats » College of Veterinary Medicine » University of Florida ...
Clefamide
Antiprotozoal agents, Acetamides, Diphenyl ethers, Primary alcohols, All stub articles, Antiinfective agent stubs). ... Clefamide (trade name Mebinol) is an antiprotozoal agent that was used to treat amoebiasis in the 1960s. There is no evidence ...
Albendazole
... (also known as albendazolum) is a broad-spectrum anthelmintic and antiprotozoal agent of the benzimidazole type. It ... Antimicrobial Agents and Chemotherapy. 57 (11): 5448-56. doi:10.1128/AAC.00843-13. PMC 3811268. PMID 23959307. Archived from ...
Glycobiarsol
Antiprotozoal agents, Organoarsenic compounds, Bismuth compounds, Acetanilides, All stub articles, Antiinfective agent stubs). ... Glycobiarsol (trade name Milibis) is an antiprotozoal agent that has been used in humans as well as in dogs. Berberian, D. A. ( ...
Infection prevention and control
Various forms of isolation exist, and are applied depending on the type of infection and agent involved, and its route of ... antivirals and antiprotozoals. The World Health Organization (WHO) has set up an Infection Prevention and Control (IPC) unit in ... According to the WHO, outbreak investigations are meant to detect what is causing the outbreak, how the pathogenic agent is ... Antimicrobial medications (aka antimicrobials or anti-infective agents) include antibiotics, antibacterials, antifungals, ...
Ionophore
... however its use as an antiprotozoal agent has widely restricted because of neurotoxic concerns. Clioquinol and PBT2 are ... It also serves as an anti-fouling agent in paints to cover and protect surfaces against mildew and algae. Clioquinol and PBT2 ... It is also used as a food additive, shelf-life extending agent in food packaging, and wood preservative in timber treatment. ... "Chapter 76:Antifungal Agents". Medical microbiology (4th ed.). Galveston, Tex.: University of Texas Medical Branch at Galveston ...
Econazole
Imidazoles devoid of the nitro group no longer have any antiprotozoal activity, however, such drugs are effective antifungal ... agents. Alkylation of imidazole (2) with bromoketone (1) prepared from o,p-dichloroacetophenone affords the displacement ... Sunderland MR, Cruickshank RH, Leighs SJ (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of ...
Glycoside
Saponins are also natural ruminal antiprotozoal agents that are potential to improve ruminal microbial fermentation reducing ... other agents are now preferred[citation needed]) and arrhythmia. These sweet glycosides found in the stevia plant Stevia ...
Imidocarb
Antiprotozoal agents, Ureas, Imidazolines, All stub articles, Antiinfective agent stubs). ... Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with ...
Tinidazole
MedlinePlus Drug Information: Tinidazole Drug Bank Facts on Tinidazole (ECHA InfoCard ID from Wikidata, Antiprotozoal agents, ...
Antiviral drug
Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad- ... These agents act on penetration and uncoating. Pleconaril works against rhinoviruses, which cause the common cold, by blocking ... Potentially, one of the benefits from the use of an effective entry-blocking or entry-inhibiting agent is that it potentially ... Rossignol JF (2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. 110: 94-103. doi:10.1016/j ...
Nitazoxanide
Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad- ... The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase ( ... Agents Chemother. 46 (7): 2116-23. doi:10.1128/aac.46.7.2116-2123.2002. PMC 127316. PMID 12069963. Nitazoxanide (NTZ) is a ... Rossignol JF (October 2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. 110: 94-103. doi: ...
Acoziborole
Antiprotozoal agents, Trifluoromethyl compounds, Organoboron compounds, Fluoroarenes, All stub articles, Antiinfective agent ... Acoziborole (SCYX-7158) is an antiprotozoal drug invented by Anacor Pharmaceuticals in 2009, and now under development by the ...
Flacourtia inermis
Its fruit is rich in an antimicrobial agent-2,3-Dihydroxybenzoic acid. The family Salicaceae includes well-known species such ... George Shibumon, Benny PJ, Kuriakose Sunny, George Cincy, Gopalakrishnan Sarala (2011) "Antiprotozoal activity of 2, 3- ... Benny PJ, George Shibumon, Kuriakose Sunny, George Cincy (2010) "2, 3-Dihydroxybenzoic Acid: An Effective Antifungal Agent ...
Chlorquinaldol
Antiprotozoal agents, Antiseptics, Chloroarenes, Quinolinols, All stub articles, Antiinfective agent stubs, Genito-urinary ... Chlorquinaldol is an antimicrobial agent and antiseptic. It is a chlorinated derivative of the popular chelating agent 8- ... Agents Chemother. 26 (1): 35-8. doi:10.1128/aac.26.1.35. PMC 179912. PMID 6236746. Kutscher, Bernhard (2020). "Dermatologicals ...
Pentamidine
Antiprotozoal agents, Amidines, DNA-binding substances, NMDA receptor antagonists, Phenol ethers, World Health Organization ...
ATCvet code QP51
... Antiprotozoals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System for ... QP51AX23 Fumagillin QP51AX24 Domperidone QP51AX25 Miltefosine QP51AX26 Clopidol QP51AX30 Combinations of other protozoal agents ...
Nicarbazin
Antiprotozoal agents, Ureas, Anilines, Nitrobenzenes, Pyrimidones). ... Reproduction responses of broiler-breeders to anticoccidial agents. Poultry Science. 69: 27-36 Polin, D, WH Ott, and OH ... Biological studies on nicarbazin, a new anticoccidial agent. Poultry Science 35: 1355-1367. World Health Organization (WHO), ...
Furazolidone
Antiprotozoal agents, Nitrofurans, Monoamine oxidase inhibitors, 2-Oxazolidinones, Hydrazones). ... Furazolidone is a nitrofuran antibacterial agent and monoamine oxidase inhibitor (MAOI). It is marketed by Roberts Laboratories ...
Philasterides dicentrarchi
The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and ... Iglesias, R.; Paramá, A.; Álvarez, MF; Leiro, J.; Sanmartín, ML (2002). "Antiprotozoals effective in vitro against the ... Mallo, Natalia; Lamas, Jesús; Leiro, José M. (2014). "Alternative oxidase inhibitors as antiparasitic agents against ... Several compounds of well-known antiprotozoal activity, including niclosamide, oxyclozanide, bithionol sulfoxide, toltrazuril, ...
List of MeSH codes (D27)
... anticestodal agents MeSH D27.505.954.122.250.075.100.750 - schistosomicides MeSH D27.505.954.122.250.100 - antiprotozoal agents ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Paromomycin
Antiprotozoal agents, Orphan drugs, World Health Organization essential medicines, Wikipedia medicine articles ready to ...
Nitrofurazone
Antiprotozoal agents, Otologicals, Semicarbazones). ...
Blastocystosis
Gonçalves AQ, Viana Jda C, Pires EM, Bóia MN, Coura JR, Silva EF (2007). "The use of the antifungal agent miconazole as an ... The reduction in the availability of antiprotozoal drugs has been noted as a complicating factor in treatment of other ... Zierdt CH, Swan JC, Hosseini J (1983). "In vitro response of Blastocystis hominis to antiprotozoal drugs". J. Protozool. 30 (2 ... Stovarsol and Narsenol, two arsenic-based antiprotozoals, were reported to be effective against the infection. Carbarsone was ...
Biocide
Biocidal substances and products are also employed as anti-fouling agents or disinfectants under other circumstances: chlorine ... An antimicrobial: this includes germicides, antibiotics, antibacterials, antivirals, antifungals, antiprotozoals, and ... preservatives and colouring agents. Since these substances may act together to produce a combination effect, an assessment of ...
Tineola bisselliella
Sunderland, M. R.; Cruickshank, R. H.; Leighs, S. J. (2014). "The efficacy of antifungal azole and antiprotozoal compounds in ... As Tineola bisselliella is the major worldwide pest for woollen products, permethrin-based agents have been commercialised for ... "The efficacy of antifungal azole and antiprotozoal compounds in protection of wool from keratin-digesting insect larvae". ...
Buparvaquone
Antiprotozoal agents, All stub articles, Antiinfective agent stubs). ... Buparvaquone is a naphthoquinone antiprotozoal drug related to atovaquone. It is a promising compound for the therapy and ...
Quinfamide
Antiprotozoal agents, Tetrahydroquinolines, Amides, 2-Furyl compounds, Phenol esters). ... New potent antiamebic agents". Journal of Medicinal Chemistry. 22 (5): 599-601. doi:10.1021/jm00191a031. PMID 458814. (Drugs ...
Fumagillin
Antiprotozoal agents, Total synthesis). ... is a complex biomolecule and used as an antimicrobial agent. It ...
2,3-Dihydroxybenzoic acid
George Shibumon; Benny PJ; Kuriakose Sunny; George Cincy; Gopalakrishnan Sarala (2011). "Antiprotozoal activity of 2, 3- ... An Effective Antifungal Agent Isolated from Flacourtia inermis Fruit". International Journal of Pharmaceutical and Clinical ...
Antimicrobial chemotherapy
... the use of antihelminthic drugs to treat worm infections Antiprotozoal chemotherapy, the use of antiprotozoal drugs to treat ... Antimicrobial chemotherapy is the clinical application of antimicrobial agents to treat infectious disease. There are five ... protozoan infections Antiviral chemotherapy, the use of antiviral drugs to treat viral infections Antimicrobial Agents and ...
Sulconazole
Sunderland MR, Cruickshank RH, Leighs SJ (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of ... Antiinfective agent stubs). ...
Clostridioides difficile infection
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative indicated as an antiprotozoal agent (FDA-approved for the ... "Cleaning agents 'make bug strong'". BBC News Online. 3 April 2006. Archived from the original on 8 November 2006. Retrieved 17 ... Several different antibiotics are used for C. difficile, with the available agents being more or less equally effective. ...
Leishmaniasis Medication: Antifungals, Systemic, Xanthine Oxidase Inhibitors, Antiprotozoal Agents, Immunomodulators,...
Antiprotozoal Agents. Class Summary. Antiprotozoan compounds are the drugs of choice in patients with visceral leishmaniasis. ... Antileishmaniasis Agents. Class Summary. Miltefosine is a new oral drug that is now approved in the United States to treat ... Since 2002, this agent has rapidly become the drug of choice for visceral leishmaniasis in India. A short-course regimen ... This agent is also effective against visceral leishmaniasis and is often the first-line treatment outside the United States. ...
Chagas Disease (American Trypanosomiasis) Medication: Antiprotozoal agents
Figure 3 | Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of...
Tetralysal
-
Anti-bacterial Agents, Antiprotozoals, ATC:J01AA04
For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease ...
IMSEAR at SEARO: The absence of interaction with alcohol of a new antiprotozoal agent Go. 10213 Cibemone.
Antitrichomonal Agents < Antiprotozoal Agents << Antiparasitic Agents <<< Anti-Infective Agents @...
Antitrichomonal Agents are agents used to treat trichomonas infections ... Antitrichomonal Agents "Antitrichomonal Agents (Antitrichomonals)" Antitrichomonal Agents. In our body, Antitrichomonal Agents ... Antitrichomonal Agents ⌊Phenomena (Phenomenon concepts). ⌊Role Phenomena (Role Concepts). ⌊Physicochemical Roles. ⌊Applications ... Anti-Infective Agents. ⌊Antiparasitic Agents. ⌊Antiprotozoal Agents. ⌊Antitrichomonal Agents. Antiprotozoal Agents ⌊. ...
X-linked Immunodeficiency With Hyper IgM Medication: Immune Globulins, Antiprotozoal agents, Antibiotics, Granulocyte-Colony...
Antiprotozoal agents. Class Summary. These agents are used for treatment of cryptosporidiosis. ... These agents are used for replacement of functional antibodies in IgG isotype. See Table 2 in Medication Summary. ... Both drugs block the folic acid metabolism cycle of bacteria and are much more active together than either agent alone. ... Elicits antiprotozoal activity by interfering with pyruvate-ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer ...
Tafenoquine - Drugs and Lactation Database (LactMed) - NCBI Bookshelf
Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii
DAHANCA 37. Re-irradiation With Proton Radiotherapy - Full Text View - ClinicalTrials.gov
Nitazoxanide: MedlinePlus Drug Information
Rapid reinfection by Giardia lamblia after treatment in a hyperendemic area: the case against treatment
Method development and validation of anti-protozoal agent- Nitazoxanide by RP-HPLC and it's stability related impurities...
Advanced Search Results - Public Health Image Library(PHIL)
Achiote | GreenMedInfo | Substance | Natural Medicine | Alternative
Anticarcinogenic Agents. 2. 4. Antiprotozoal Agents. 2. 4. Nitric Oxide Inhibitor. 2. 4. ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic. Additional Keywords : ... Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation, ... Pharmacological Actions : Antineoplastic Agents, Apoptotic. Additional Keywords : Natural Substance Synergy, Phytotherapy, ...
Apple Health (Medicaid) drug coverage criteria | Washington State Health Care Authority
Bestochem Formulations (India) Ltd. Company
This medication is an anti-protozoal agent, prescribed for intestinal amoebiasis. More Info ... This medication is an anti-platelet agent, that is, a drug that inhibits the ability of platelets to clump together as part of ... This medication is an antibiotic agent, prescribed for tuberculosis (TB) either alone or with other medications. More Info ... This medication is a haemostatic agent, prescribed for the management of blood loss in menorrhagia, and after surgery.. More ...
Study Guide for Lehne's Pharmacology for Nursing Care - Elsevier eBook on VitalSource, 10th Edition - 9780323610360
Antiprotozoal Drugs I: Antimalarial Agents 99. Antiprotozoal Drugs II: Miscellaneous Agents 100. Ectoparasiticides ... Antifungal Agents 93. Antiviral Agents I: Drugs for Non-HIV Viral Infections 94. Antiviral Agents II: Drugs for HIV Infection ... Anticancer Drugs I: Cytotoxic Agents 103. Anticancer Drugs II: Hormonal Agents, Targeted Drugs, and Other Noncytotoxic ... Agents Affecting the Volume and Ion Content of Body Fluids. UNIT VII: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, AND BLOOD 43 ...
antiprotozoal properties | NAL Agricultural Thesaurus
ChemIDplus - 564-25-0 - JBIWCJUYHHGXTC-AKNGSSGZSA-N - Doxycycline [USAN:INN:BAN] - Similar structures search, synonyms,...
Acanthamoeba Keratitis Associated with Contact Lenses --
United States
Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone
... or antiprotozoal agents [14] . The quinones are known to be electron transporters (e.g. ubiquinone, vitamin K), and are ... The resistance to antifungal agents and the changes in the prevalence of species Candida albicans are related as the causes of ... The indiscriminate use of antifungal agents in the treatment of these infections has led to the development of drug resistance ... Ghannoum, M.A. and Rice, L.B. (1999) Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These ...
Antibiotics During Pregnancy May Increase Miscarriage Risk
Specific Anti-biofilm Activity of Carbon Quantum Dots by Destroying P. | IJN
9. Fung HB, Doan T-L. Tinidazole: a nitroimidazole antiprotozoal agent. Clin Ther. 2005;27(12):1859-1884. doi:10.1016/j. ... Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action. Virulence. 2018;9(1 ... Bioinspired carbon quantum dots: an antibiofilm agents. J Nanosci Nanotechnol. 2019;19(4):2339-2345. doi:10.1166/jnn.2019.16537 ... With the development of nanomedicine, nanomaterials have been developed as antibacterial agents to treat bacterial infectious ...
Utilisation of peptides against microbial infections - a review
Clostridioides difficile infection - Wikipedia
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative indicated as an antiprotozoal agent (FDA-approved for the ... "Cleaning agents make bug strong". BBC News Online. 3 April 2006. Archived from the original on 8 November 2006. Retrieved 17 ... Several different antibiotics are used for C. difficile, with the available agents being more or less equally effective.[71] ...
Aczone (Dapzone) vs. Mepron Prescription Treatment for Skin Infections: Differences and Side Effects
SKIN-HAIR-NAILS Archives - Occupational and Environmental Medicine | North Charleston SC
Antibacterial4
- Dapsone is an antibacterial medication and Mepron is an antiprotozoal agent. (rxlist.com)
- Flagyl 400 MG Tablet is an antibacterial and antiprotozoal agent, which is used in treating the various infections of the gastrointestinal tract, genital areas, joints, skin, and other areas of the body. (xshotpix.com)
- Metronidazole is an antibacterial and antiprotozoal agent active against a large number of pathogenic microorganisms. (pharmacyplanet.com)
- Mechanism of action tinidazole is an antiprotozoal, antibacterial agent. (larumbejoyeros.com)
Nitazoxanide3
- Nitazoxanide is in a class of medications called antiprotozoal agents. (medlineplus.gov)
- 11] Fox L.M., Saravolatz L.D., Nitazoxanide: A new thiazolide antiparasitic agent, Clin. (degruyter.com)
- Alinia is made up of Nitazoxanide which is a antiprotozoal agent. (mydrugcenter.com)
Metronidazole4
- It is slightly soluble in alcohol and has a solubility in water of 10 mg/mL at 20°C. Metronidazole is a member of the imidazole class of anti-bacterial agents and is classified as an antiprotozoal and anti-bacterial agent. (clustermed.info)
- WARNING: POTENTIAL RISK FOR CARCINOGENICITY See full prescribing information for complete boxed warning Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent 13.1). (drugcentral.org)
- Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent 13.1). (drugcentral.org)
- As albendazole is an available and safe antiprotozoal medicine in the Islamic Republic of Iran and perhaps in other parts of the world, we conducted a clinical trial in order to assess the anti-giardial effects compared to metronidazole. (who.int)
Antifungal agents3
- The indiscriminate use of antifungal agents in the treatment of these infections has led to the development of drug resistance. (scirp.org)
- Recent studies support investigating drugs with specific targets, suggesting a change of focus to the development of new antifungal agents capable of inhibiting virulence factors. (scirp.org)
- We show that both contain antiprotozoal and nematicidal (i.e. worm destroying) compounds, while the latter also contains antifungal agents. (ramblinpines.com)
Cutaneous1
- This agent is not approved for the cutaneous or mucosal forms of the disease. (medscape.com)
Antimicrobial1
- Make every effort to obtain samples for pathogen identification and use specific antimicrobial agents. (medscape.com)
Leishmaniasis3
- Alternative treatment regimens with acceptable cure rates but that are not FDA approved for treating selected cases of leishmaniasis are parenteral agents pentamidine and amphotericin B deoxycholate, as well as oral agents ketoconazole, itraconazole, and fluconazole. (medscape.com)
- Miltefosine is the sole oral agent that has been shown to be effective against leishmaniasis. (medscape.com)
- This medication was developed first as an antineoplastic agent and later found to have considerable antiproliferative activity against leishmaniasis as well as against other trypanosome parasites. (medscape.com)
Medication1
- This medication is a potent and quick acting antimalarial agent,used for treating chloroquine resistant falciparum malaria,including cerebral malaria. (medindia.net)
Humans2
- ART and its analogs are generally regarded as low toxic agents since a lot of studies in humans have demonstrated its excellent safety and tolerability as well as shown in some animal species such as rats, dogs and chickens [ 3,4, 14,15 ]. (avensonline.org)
- Although, there are numerous studies on PK of ART and its derivatives alone or in combination with other antimalarial agents in humans, as well as a few related studies in rats and dogs [ 3 ], there are few, if any, PK studies on ART in poultry. (avensonline.org)
Therapeutic1
- Manufacturers are exploiting nanotechnology in the antiemetics and antinauseants market to deliver therapeutic agents to specifically targeted sites in a controlled manner through Nanomedicine and Nano delivery systems. (thebusinessresearchcompany.com)
Tinidazole2
Quinacrine1
- The most prominent cases is not defined, and some agents (e.g., quinacrine) are effect of nitroimidazole combination was found for al- often unavailable. (cdc.gov)
Mechanism1
- The prototypical antimalarial agent with a mechanism that is not well understood. (nih.gov)
Substances1
- In our body, Antitrichomonal Agents (Antitrichomonals) are exogenous substances used to treat trichomonas infections . (wellnessadvantage.com)
Infections1
- These agents are used to treat infections caused by the protozoan T cruzi . (medscape.com)
Adult1
- METHODS: We created an agent-based model representing the Chicago population and conducted experiments to determine the effects of varying adult out-of-household activities (OOHA), school reopening, and protective behaviors across age groups on COVID-19 transmission and hospitalizations. (bvsalud.org)
Antiviral agent1
- Remdesivir is an antiviral agent that inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which is essential for viral replication. (medscape.com)
Drugs3
- Cost issues prevent the use of liposomal drugs in most countries, where the mainstay of treatment is still prolonged intravenous treatment with antimonial agents, despite ever-increasing patterns of resistance and an increasing incidence of treatment failures. (medscape.com)
- 14. Dermatological drugs, topical agents, and cosmetics (A.C. De Groot). (who.int)
- 28. Antiprotozoal drugs (M. Schneemann). (who.int)
Synthetic1
- c) Singh S., Bharti N., Mohapatra P.P., Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents, Chem. (degruyter.com)
Activity2
- The free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activity. (ncats.io)
- In the field of veterinary medicine, ART has attracted the attention of a great number of researchers to explore its activity against Eimeria spp.the causative agents of avian coccidiosis [ 9-11 ]. (avensonline.org)
Abstract1
- abstract = "Clinically normal Nubian goats were given the antiprotozoal drug imidocarb at single intramuscular doses of 6, 12, 18 and 24 mg/kg, and the various clinical, biochemical and pathological manifestations were recorded. (elsevier.com)
Potent1
- Avermectins, new family of potent ant helmintic agent s: p roducing papilloma chinese meaning and fermentation[omucoxideh. (localuri-iasi.ro)
Treatment1
- Mepron (atovaquone) is an antiprotozoal agent indicated for the prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim -sulfamethoxazole (TMP-SMX) and is indicated for the acute oral treatment of mild-to-moderate PCP in patients who are intolerant to TMP-SMX. (rxlist.com)
Drug resistance1
- It is an attractive agent in areas, such as India, that have drug resistance against traditional chemotherapy. (medscape.com)
Form1
- Some plants have foaming agents like soluble leaf proteins, saponins, and hemicelluloses that are responsible to form a monomolecular layer around gas rumen bubbles that makes it more stable at specific pH. (farmanimalreport.com)
Development1
- This finding indicates that N-substituted aminothiazole scaffold should be investigated for the development of highly selective anti-giardial agent. (degruyter.com)