Substances that are destructive to protozoans.
A hemoflagellate subspecies of parasitic protozoa that causes Rhodesian sleeping sickness in humans. It is carried by Glossina pallidipes, G. morsitans and occasionally other species of game-attacking tsetse flies.
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
Infections with unicellular organisms formerly members of the subkingdom Protozoa.
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
A plant genus of the family ASTERACEAE. Members contain scandenolide (a sesquiterpene lactone) and germacranolides.
The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.
A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). Human infections are confined almost entirely to children. This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental host. Transmission is by Phlebotomus sandflies.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Infection with protozoa of the genus TRYPANOSOMA.
Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.
A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
A species of parasitic protozoa causing ENTAMOEBIASIS and amebic dysentery (DYSENTERY, AMEBIC). Characteristics include a single nucleus containing a small central karyosome and peripheral chromatin that is finely and regularly beaded.
A plant genus of the family RUTACEAE. Members contain quinoline alkaloids.
A plant genus of the family VERBENACEAE. Lippsidoquinone; TRITERPENES; SESQUITERPENES; and THYMOL have been found in this genus. Plant extracts have cytotoxic activity. It is sometimes called Mexican oregano but that confuses it with real oregano (ORIGANUM).
A genus of ameboid protozoa characterized by the presence of beaded chromatin on the inner surface of the nuclear membrane. Its organisms are parasitic in invertebrates and vertebrates, including humans.
Infection with amoebae of the genus ENTAMOEBA. Infection with E. histolytica causes DYSENTERY, AMEBIC and LIVER ABSCESS, AMEBIC.
A species of parasitic protozoa having both an ameboid and flagellate stage in its life cycle. Infection with this pathogen produces PRIMARY AMEBIC MENINGOENCEPHALITIS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A free-living soil amoeba pathogenic to humans and animals. It occurs also in water and sewage. The most commonly found species in man is NAEGLERIA FOWLERI which is the pathogen for primary amebic meningoencephalitis in primates.
Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.
A species of hydatid tapeworm (class CESTODA) in the family Taeniidae, whose adult form infects the DIGESTIVE TRACT of DOGS, other canines, and CATS. The larval form infects SHEEP; PIGS; HORSES; and may infect humans, where it migrates to various organs and forms permanent HYDATID CYSTS.
An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.
Species of tapeworm in the genus TAENIA, that infects swine. It is acquired by humans through the ingestion of cured or undercooked pork.
Agents used to treat tapeworm infestations in man or animals.
A genus of very small TAPEWORMS, in the family Taeniidae. The adult form is found in various CARNIVORA but not humans. The larval form is seen in humans under certain epidemiologic circumstances.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Infections with protozoa of the phylum CILIOPHORA.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Five membered rings containing a NITROGEN atom.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Persistent damage to Enterocytozoon bieneusi, with persistent symptomatic relief, after combined furazolidone and albendazole in AIDS patients. (1/1602)

AIM: To investigate morphological changes in Enterocytozoon bieneusi and the duration of symptomatic relief after combination treatment with furazolidone and albendazole in AIDS patients. METHODS: Four severely immunocompromised AIDS patients with symptomatic E bieneusi infection of the gut received an 18 day course of combined furazolidone and albendazole (500 + 800 mg daily). All patients were monitored for parasite shedding in stool by light microscopy at the end of treatment and monthly during follow up. At the end of treatment, duodenal biopsy specimens obtained from three patients were studied by transmission electron microscopy by two pathologists blind to the patients' treatment or clinical outcome. Duodenal biopsy specimens obtained from one of the patients two months after completion of treatment were also studied electronmicroscopically. RESULTS: All patients had long lasting symptomatic relief, with a major decrease--or transient absence--of spore shedding in stools from completion of treatment. After treatment, changes in faecal spores were persistently found by light microscopy in all cases, and there was evidence of both a substantial decrease in the parasite load and ultrastructural damage in the parasite in all biopsy specimens. The treatment was well tolerated, and no patient had clinical or parasitological relapse during follow up (up to 15 months). CONCLUSIONS: The long lasting symptomatic relief observed in all four treated patients correlated with the persistent decrease in parasite load both in tissue and in stool, and with the morphological changes observed in the life cycle of the protozoan. These data suggest that combined treatment with furazolidone and albendazole is active against E bieneusi and may result in lasting remission even in severely immunocompromised patients.  (+info)

U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. (2/1602)

In August 1997, AmBisome (liposomal amphotericin B, Nexstar, San Dimas, CA) was the first drug approved for the treatment of visceral leishmaniasis by the U.S. Food and Drug Administration. The growing recognition of emerging and reemerging infections warrants that safe and effective agents to treat such infections be readily available in the United States. The following discussion of the data submitted in support of the New Drug Application for AmBisome for the treatment of visceral leishmaniasis shows the breadth of data from clinical trials that can be appropriate to support approval for drugs to treat tropical diseases.  (+info)

Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. (3/1602)

Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb.  (+info)

Value of Western blotting in the clinical follow-up of canine leishmaniasis. (4/1602)

Specific serum antibody levels in Leishmania infantum-infected dogs treated with a combination of glucantime and allopurinol were estimated by indirect immunofluorescence and Western blotting. The sensitivity of Western blot was greater than that obtained with immunofluorescence titration. In general, both diagnostic methods concurred with the post-treatment clinical status of the animals. Clinical improvement of successfully treated dogs was related to lower immunofluorescence titers and simpler and/or less reactive immunodetection patterns in Western blotting. The recognition, by infected dogs, of certain low molecular weight antigens, particularly one of approximately 26 kDa, was restricted to pretreatment samples and a single animal in relapse thus apparently constituting an active infection marker.  (+info)

Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii. (5/1602)

The activity of recombinant bactericidal/permeability-increasing protein (rBPI21), alone or in combination with sulfadiazine, on the intracellular replication of Toxoplasma gondii was assessed in vitro and in mice with acute toxoplasmosis. rBPI21 markedly inhibited the intracellular growth of T. gondii in human foreskin fibroblasts (HFFs). Following 72 h of exposure, the 50% inhibitory concentration of rBPI21 for T. gondii was 2.6 micrograms/ml, whereas only slight cytotoxicity for HFF cells was observed at the concentrations tested. Subsequent mathematical analyses revealed that the combination of rBPI21 with sulfadiazine yielded slight to moderate synergistic effects against T. gondii in vitro. Infection of mice orally with C56 cysts or intraperitoneally (i.p.) with RH tachyzoites resulted in 100% mortality, whereas prolongation of the time to death or significant survival (P = 0.002) was noted for those animals treated with 5 to 20 mg of rBPI21 per kg of body weight per day. Treatment with rBPI21 in combination with sulfadiazine resulted in significant (P = 0.0001) survival of mice infected i.p. with tachyzoites but not of mice infected orally with T. gondii cysts. These results indicate that rBPI21 is active in vitro and in vivo against T. gondii and that its activity is significantly enhanced when it is used in combination with sulfadiazine. To our knowledge, this is the first report of the activity of rBPI21 against a protozoan parasite.  (+info)

Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. (6/1602)

A wide variety of biologically active compounds contain indole and quinoline nuclei. Some novel indolylquinoline derivatives were synthesized from indole by Friedel-Crafts acylation reaction. Out of the four derivatives tested, 2-(2''-acetamidobenzyl)-3-(3'-indolylquinoline) (C) had no effect on the promastigotes or amastigotes of Leishmania donovani in vitro. The remaining three analogues, 2-(2''-dichloroacetamidobenzyl)-3-(3'-indolylquinoline) (A), 2-(2''-chloroacetamidobenzyl)-3-(3'-indolylquinoline) (B), and 2-(2''-aminobenzyl)-3-(3'-indolylquinoline) (D), inhibited the growth of L. donovani promastigotes in vitro and were cytotoxic to both the promastigote and amastigote forms of the parasite. These three derivatives were also effective in eliminating L. donovani amastigotes from BALB/c mouse peritoneal macrophages in vitro. One indolylquinoline derivative [A] was used to treat established visceral leishmaniasis in BALB/c mice. This compound was significantly more effective than sodium antimony gluconate (SAG) in reducing the splenic parasite load at a much lower concentration (5% of SAG). Our results suggest that indolylquinoline derivatives may be exploited as antileishmanial agents.  (+info)

What controls glycolysis in bloodstream form Trypanosoma brucei? (7/1602)

On the basis of the experimentally determined kinetic properties of the trypanosomal enzymes, the question is addressed of which step limits the glycolytic flux in bloodstream form Trypanosoma brucei. There appeared to be no single answer; in the physiological range, control shifted between the glucose transporter on the one hand and aldolase (ALD), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), and glycerol-3-phosphate dehydrogenase (GDH) on the other hand. The other kinases, which are often thought to control glycolysis, exerted little control; so did the utilization of ATP. We identified potential targets for anti-trypanosomal drugs by calculating which steps need the least inhibition to achieve a certain inhibition of the glycolytic flux in these parasites. The glucose transporter appeared to be the most promising target, followed by ALD, GDH, GAPDH, and PGK. By contrast, in erythrocytes more than 95% deficiencies of PGK, GAPDH, or ALD did not cause any clinical symptoms (Schuster, R. and Holzhutter, H.-G. (1995) Eur. J. Biochem. 229, 403-418). Therefore, the selectivity of drugs inhibiting these enzymes may be much higher than expected from their molecular effects alone. Quite unexpectedly, trypanosomes seem to possess a substantial overcapacity of hexokinase, phosphofructokinase, and pyruvate kinase, making these "irreversible" enzymes mediocre drug targets.  (+info)

Cost-effectiveness analysis of humanitarian relief interventions: visceral leishmaniasis treatment in the Sudan. (8/1602)

Spending by aid agencies on emergencies has quadrupled over the last decade, to over US$6 billion. To date, cost-effectiveness has seldom been considered in the prioritization and evaluation of emergency interventions. The sheer volume of resources spent on humanitarian aid and the chronicity of many humanitarian interventions call for more attention to be paid to the issue of 'value for money'. In this paper we present data from a major humanitarian crisis, an epidemic of visceral leishmaniasis (VL) in war-torn Sudan. The special circumstances provided us, in retrospect, with unusually accurate data on excess mortality, costs of the intervention and its effects, thus allowing us to express cost-effectiveness as the cost per Disability Adjusted Life Year (DALY) averted. The cost-effectiveness ratio, of US$18.40 per DALY (uncertainty range between US$13.53 and US$27.63), places the treatment of VL in Sudan among health interventions considered 'very good value for money' (interventions of less than US$25 per DALY). We discuss the usefulness of this analysis to the internal management of the VL programme, the procurement of funds for the programme, and more generally, to priority setting in humanitarian relief interventions. We feel that in evaluations of emergency interventions attempts could be made more often to perform cost-effectiveness analyses, including the use of DALYs, provided that the outcomes of these analyses are seen in the broad context of the emergency situation and its consequences on the affected population. This paper provides a first contribution to what is hoped to become an international database of cost-effectiveness studies of health interventions during relief operations, which use a comparable measure of health outcome such as the DALY.  (+info)

Antiprotozoal drugs are medicines that are used to treat a variety of diseases caused by protozoa. Protozoa are one-celled organisms, such as amoebas. Some are parasitic and cause infections in the body. African sleeping sickness,giardiasis, amebiasis, Pneumocystis carinii pneumonia (PCP), and malaria are examples of diseases caused by protozoa.. Antiprotozoal drugs come in liquid, tablet, and injectable forms and are available only with a doctors prescription. Some commonly used antiprotozoal drugs are metronidazole (Flagyl), eflornithine (Ornidyl), furazolidone (Furoxone), hydroxychloroquine (Plaquenil), iodoquinol (Diquinol, Yodoquinol, Yodoxin), and pentamidine (Pentam 300). The recommended dosage depends on the type ofantiprotozoal drug, its strength, and the medical problem for which it is being used. Check with the physician who prescribed the drug or the pharmacistwho filled the prescription for the correct dosage. Always take antiprotozoaldrugs exactly as directed.. Some people feel ...
View list of generic drugs that are classified under Antiprotozoal Agents, Amebicides along with ICD Code. Find related prescribing information and price details for each drug listed under it.
Antiprotozoal agents (ATC code: ATC P01) is a class of pharmaceuticals used in treatment of protozoan infection. Protozoans have little in common with each other (for example, Entamoeba histolytica, an unikont eukaryotic organism, is less closely related to Naegleria fowleri, a bikont eukaryotic organism, than it is to Homo sapiens, which belongs to the unikont phylogenetic group) and so agents effective against one pathogen may not be effective against another. They can be grouped by mechanism or by organism. Recent papers have also proposed the use of viruses to treat infections caused by protozoa. Antiprotozoals are used to treat protozoal infections, which include amebiasis, giardiasis, cryptosporidiosis, microsporidiosis, malaria, babesiosis, trypanosomiasis, Chagas disease, leishmaniasis, and toxoplasmosis. Currently, many of the treatments for these infections are limited by their toxicity. The mechanisms of antiprotozoal drugs differ significantly drug to drug. For example, it appears ...
BioAssay record AID 774779 submitted by ChEMBL: Antiprotozoal activity against axenic amastigote form of Leishmania donovani MHOM/ET/67/L82 assessed as parasite growth inhibition.
Broxaldine | Antiprotozoal drug | Brobenzoxaldine | CAS [3684-46-6] | Axon 2804 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research
Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models. Azithromycin decreased viability of promastigote cultures of Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi as determined by the colorimetric Alamar blue assay. In amastigote intracellular cultures, a significant decrease in infected macrophages counts was observed for all three species with IC50 of 20.83 (27 μ mol/L), 2.18 (2.7 μmol/L), and 6.12 (7.8 μmol/L) μg/mL, respectively. Azithromycin showed in vitro activity against L. (L.) amazonensis, L. (V.) braziliensis, and L. (L.) chagasi and may offer an alternative to current leishmaniasis treatment.
View Anitbacterial & Antiprotozoal shopping areas from our Pharmacy catalog. Shop Pharmacy in our Anitbacterial & Antiprotozoal department online made by Vedco. Shop, sign-up and save, or request your free Pharmacy catalog. Free Shipping on Anitbacterial & Antiprotozoal products for orders over $60.
Sixteen 1,4-diaryl-1,2,3-triazole compounds 4-19 derived from the tetrahydrofuran neolignans veraguensin 1, grandisin 2, and machilin G 3 were tested against Leishmania (Leishmania) amazonensis intracellular amastigotes. Triazole compounds 4-19 were synthetized via Click Chemistry strategy by 1,3-dipolar cycloaddition between terminal acetylenes and aryl azides containing methoxy and methylenedioxy groups as substituents. Our results suggest that most derivatives were active against intracellular amastigotes, with IC50 values ranging from 4.4 to 32.7 µM. The index of molecular hydrophobicity (ClogP) ranged from 2.8 to 3.4, reflecting a lipophilicity/hydrosolubility rate suitable for transport across membranes, which may have resulted in the potent antileishmanial activity observed. Regarding structure-activity relationship (SAR), compounds 14 and 19, containing a trimethoxy group, were the most active (IC50 values of 5.6 and 4.4 µM, respectively), with low cytotoxicity on mammalian cells (SI = 14.1
Bark used as expectorant and for asthma.. • In Africa, bark root used for pulmonary problems; leaf for leprosy, and flower for kidney ailments and as diuretic.. • In West Nigeria, leaves and stems soaked and boiled in water, used for skin rashes. (see source study). • In India, reported Mawasi tribal use of flowers for diarrhea. (see source study). Scientific studies on the benefits and uses of the monkey tail. • Antimicrobial:. Studies of leaf extracts isolated gallic acid, corilagin and geranin responsible for antimicrobial activity.. • Trypanocidal/ antiprotozoal agent:. Aqueous extract of Acalypha hispida leaves suggest trypanocidal effect.. • Anti-ulcer / Anti-tumor:. Studies yielded geraniin and dehydroellagitannins which suggest diverse biological properties including anti-ulcer and anti-tumor effects, antibacterial activity against helicobacter pylori and antifungal activity.. • Phytochemicals:. Phytochemical studies yield phenolics, flavonoids, hydroxyanthraquinones and ...
REIMAO, JULIANA QUERO... Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evidence-based Complementary and Alternative Medicine n. p. 2016. Journal article.
Nidazol is an antiprotozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis
Therapy obviously depends as to the precise nature of the problem. Some neuromuscular diseases have a specific therapy for example endocrine disorders (hyperthyroidism, diabetes mellitus); Myasthenia gravis (Pyridostigmine and immunosuppressive therapy); and antiprotozoal agents for Toxoplasmosis and Neosporosis. For many degenerative neuropathies there is no treatment however some improve when given dietary supplements such as the mitochondrial co-factor L-Carnitine 50mg/kg twice daily and anti-oxidants such as gamma linoleic acid and omgea-3-fatty acids. Many severely tetraparetic animals will require considerable supportive care as well. For example, a pet which is unable to swallow may require feeding through a (PEG) tube into the stomach ...
The obscure antiprotozoal drug suramin has the prettiest molecular structure Ive ever seen. It also has some evidence as a potential treatment for autism based on a cell danger response model of the condition.. Im not going to get too excited here, because there are a lot of things that can cure stuff in mice. Still, one has to ask - an antiprotozoal? Really?. Protozoa are primitive little parasites kind of like bacteria. The most famous is plasmodium, which causes malaria. Theres not much reason an antiprotozoal drug should cross-react with the brain, so if it does treat autism its probably just a coincidence.. But its a pretty common one. Ive already noted how an antibiotic used to treat acne, minocycline, is a promising schizophrenia treatment. The news article on such is called Scientists Shocked To Find Antibiotics Alleviate Symptoms Of Schizophrenia, but maybe by this point they should start being less shocked.. Off the top of my head, I can think of two other antibiotics with a ...
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Laboratory : Université Paris-Sud, UMR 8076 CNRS BioCIS,Team « Chimiothérapie Antiparasitaire » (Director : Philippe LOISEAU). Supervisor : Sébastien POMEL. Keywords:. Leishmania, Chemotherapy, Mechanism of action, vesicular trafficking. Profile and skills: PhD with strong background in cellular and molecular biology. A previous experience in in vivo experimentations will be appreciated. Knowledge in parasitology is not a prerequisite.. Description of the project:. A drug candidate, and its back-up, for the treatment of visceral leishmaniasis were identified from in vitro and in vivo experimentations, in collaboration with CEA Saclay. These compounds were selected to be inactive on the axenic amastigote form itself in order to prevent a risk of drug resistance, but very active on the intramacrophage form. Previous works have shown that a derivative of these compounds inhibit the retrograde transport and the formation of the parasitophorous vacuole.. The objectives of the project consist in ...
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and costs that are prohibitive commonly for patients from the tropical endemic countries. There is an urgent need for new drugs as a treatment solution for this neglected disease. Here the authors describe the development and implementation of an automated high-throughput viability screening assay for the discovery of new drugs against Leishmania. Assay validation was done with Leishmania promastigote forms, and included the screening of 4000 compounds with known pharmacological properties. In an attempt to find new compounds with leishmanicidal properties, 26,500 structurally diverse chemical compounds were screened. A cut-off of 70% growth inhibition in the primary screening led to the identification of 567 active compounds. Cellular toxicity and selectivity were responsible for the exclusion of 78% of the pre-selected compounds. The activity of the remaining 124 compounds was ...
Buy Actisite Online! Actisite is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. It has a role as an antimicrobial agent, an antibacterial drug, an antiprotozoal drug, a protein synthesis inhibitor and an Escherichia coli metabolite.
Hymenidin (AG-CN2-0503), CAS 107019-95-4, is a high purity chemical. Isolated from sponge Stylissa sp. Inhibitor of CDK5/p25 and GSK3beta. Antagonist of serotonergic receptors. Moderate anticancer. Antibacterial and antiprotozoal.
Buy Anazol Online! Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.
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Looking for online definition of Antiprotozoal Drugs in the Medical Dictionary? Antiprotozoal Drugs explanation free. What is Antiprotozoal Drugs? Meaning of Antiprotozoal Drugs medical term. What does Antiprotozoal Drugs mean?
Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality is becoming a major public health problem worldwide, especially in developing countries. Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. We collected 32 plants used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal activity against E. histolytica trophozoites using in vitro tests. Only 18 extracts showed a significant inhibiting activity and among them six plant extracts showed more than 80% growth inhibition against E. histolytica at a concentration of 150 µg/mL and the IC50 values of these extracts were determined. Lippia graveolens Kunth and Ruta chalepensis Pers. showed the more significant antiprotozoal activity (91
S100 calcium‑binding protein B (S100B) is highly expressed in glioma cells and promotes cancer cell survival via inhibition of the p53 protein. In melanoma cells, this S100B‑p53 interaction is known to be inhibited by pentamidine isethionate, an antiprotozoal agent. Thus, the aim of the present study was to evaluate the effect of pentamidine on rat C6 glioma cell proliferation, migration and apoptosis in vitro. The change in C6 cell proliferation following treatment with pentamidine was determined by performing a 3‑[4,5‑dimethylthiazol‑2‑yl]‑2,5 diphenyltetrazolium bromide‑formazan assay. Significant dose‑dependent decreases in proliferation were observed at pentamidine concentrations of 0.05 μM (58.5±5%; P,0.05), 0.5 μM (40.6±7%; P,0.01) and 5 μM (13±4%; P,0.001) compared with the control (100% viability). Furthermore, treatment with 0.05, 0.5 and 5 μM pentamidine was associated with a significant increase in apoptosis versus the untreated cells, as determined by DNA ...
Our previous research show that chalcones display potent antileishmanial and antimalarial actions in vitro and in vivo. than that for FRD. These results suggest that FRD, among the enzymes from the parasite respiratory string, might be the precise focus on for the chalcones examined. Since FRD is available in the parasite and will not can be found in mammalian cells, maybe its an excellent focus on for antiprotozoal medications. Leishmaniasis is a significant and increasing open public health problem, especially in Africa, Asia, and Latin America (23, 37). Some 350 million folks are vulnerable to infections with spp., and a lot more than 12 million folks are contaminated with different types of the parasite. Every year, a couple of 1.5 million new cases, and 500,000 of the are visceral leishmaniasis, which s almost always fatal if still left untreated (23). Treatment of leishmaniasis is certainly unsatisfactory for the reason that the existing medications need repeated parenteral ...
Chemotherapy of leishmaniasis is principally predicated on antimonials. and 13e werent dangerous against fibroblasts, macrophages, or dendritic cells. Jointly, these results claim that the aziridine-2,3-dicarboxylates 13b and 13e are potential antileishmanial business lead substances with low toxicity against web host cells and selective antiparasitic results. Chemotherapy against leishmaniasis is situated generally on antimony substances, initially defined in 1912 by Vianna (42) in Brazil as trivalent antimonials [Sb(III)]. These substances display high toxicity and a small therapeutic window, conditions that led to the introduction of the pentavalent antimonium [Sb(V)] agencies sodium stibogluconate (Pentostam) and meglumine antimoniate (Glucantime), presented around 1940 (31, 38). Pentavalent antimonium substances display a wider healing window and therefore became the medications of preference against leishmaniasis. Nevertheless, their toxicity causes critical unwanted effects that PXD101 ...
Anti-Leishmanial Activity In Vitro and In Vivo of Allicin and Allicin Cream Using Leishmania major Sub-strain Zymowme LON4 and Balb-c Mice. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
BioAssay record AID 384320 submitted by ChEMBL: Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1.
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A 5-year-old American girl presents with a 1-week history of intermittent chills, fever, and sweats. She had returned home 2 weeks earlier after leaving the United States for the first time to spend 3 weeks with her grandparents in Nigeria. She received all standard childhood immunizations, but no additional treatment before travel, since her parents have returned to their native Nigeria frequently without medical consequences. Three days ago, the child was seen in an outpatient clinic and diagnosed with a viral syndrome. Examination reveals a lethargic child, with a temperature of 39.8°C (103.6°F) and splenomegaly. She has no skin rash or lymphadenopathy. Initial laboratory studies are remarkable for hematocrit 29.8%, platelets 45,000/mm3, creatinine 2.5 mg/dL (220 μmol/L), and mildly elevated bilirubin and transaminases. A blood smear shows ring forms of Plasmodium falciparum at 1.5% parasitemia. What treatment should be started? ...
Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a terrible toll of human life, health and productivity, especially in tropical and subtropical regions, and are also highly significant in animal health worldwide. Antiparasitic drugs are the mainstays of control of most of these diseases, but in many cases current therapies are inadequate and in some the situation is deteriorating because of drug resistance. Microtubules, as essential components of almost all eukaryotic cells, are proven drug targets in many helminth diseases and show promise as targets for the development of new antiprotozoal drugs. Objective: This article reviews the chemistry of the microtubule inhibitors in current use and under investigation as antiparasitic agents, their activities against the major parasites and their mechanisms of action. New directions in both inhibitor chemistry and biological evaluation are discussed. Conclusions: The most promising immediate avenues for discovery and
This trial investigateD the tolerability and efficacy of sodium stibogluconate + interferon alpha 2b [CDDP]+ cisplatin + vinblastine [VBL] + dacarbazine [DTIC]
C-reactive protein (CRP) is an acute phase protein that binds to surface structures of a number of different organisms. Leishmania donovani express CRP ligand when first entering the mammalian host and CRP has been shown to alter macrophage function. The aim of this study was to investigate the functional significance of CRP-mediated uptake of L. donovani on survival of the parasite within human macrophages and macrophage cell responses to the infection. CRP opsonized L. donovani uptake was inhibitable by including excess CRP in the fluid phase, suggesting Fc receptor usage rather than indirect complement-mediated uptake. Comparing equivalent initial infection loads, parasite survival over 72 h within peripheral blood derived macrophages (PBMs) and differentiated U937 cells was unaltered by CRP. Whereas CRP increased macrophage responses to phosphorylcholine coated erythrocytes, no significant alteration in tumour necrosis factor-alpha, interleukin (IL)-10 or IL-12 production from PBMs was ...
metronidazole500mg.biz/gel 4.8.4. Metronidazole gel is an antiprotozoal antobiotic administered to patients to treat infections caused with bacteria The medicine is available in different forms: capsules, cream, Metronidazole gel. - Download PC Soft
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Cases of visceral leishmaniasis (VL) in the course of human immunodeficiency virus (HIV) infection have regularly been recorded, mainly in southern Europe. HIV infection can increase the risk of VL development by 10-100 times in endemic areas. We describe the occurrence of this co-infection in 15 patients from Brazil. The mean age of the patients was 38 +/- 8.8 yr, with 86.6% males. The mean time between HIV diagnosis and the onset of visceral leishmaniasis was 44 +/- 39 mo. The main signs and symptoms presented at admission were splenomegaly (73%), weight loss (73%), cough (67%), fever (67%), asthenia (60%), and diarrhea (60%). The mean T CD4+ lymphocyte count was 173.7 +/- 225.6 cells/mm3, and viral load was 51,030 +/- 133,737/mm3. Treatment consisted of pentavalent antimonials (67% of cases). Most (87%) patients recovered from VL infection; death occurred in 1 patient due to septic shock. VL is an important opportunistic infection in HIV patients, which is potentially fatal, even when correct
COVID-19 due to SARS-CoV-2 infection is a rapidly escalating global pandemic for which there is no proven effective treatment. COVID-19 is multi-dimensional disease caused by viral cytopathic effects and host-mediated immunopathology. Therapeutic approaches should logically be based on interventions that have direct anti-viral effects and favourably modulate the host immune response. Thus, an optimal drug regimen in ambulatory patients should collectively (i) target and reduce viral replication, (ii) upregulate host innate immune anti-viral responses, (iii) have favourable immunomodulatory properties, and (iv) minimise disease progression to hospitalisation thus circumventing the cytokine storm that likely underpins ARDS and multi-organ failure. Nitazoxanide (NTZ) is an antiprotozoal drug that is FDA-approved for treating Cryptosporidium and Giardia and has an excellent safety record for a variety of indications, but primarily as an anti-parasitic agent. It has proven broad anti-viral activity ...
Hexadecylphosphocholine (HePC, miltefosine) is an alkylphospholipid used clinically for the topical treatment of cancer and against leishmaniasis. The mechanism of action of HePC, not yet elucidated, involves its insertion into the plasma membrane, affecting lipid homeostasis. It has also been proposed that HePC directly affects lipid raft stability and function in cell membranes. The present work deals with two main questions in the understanding of the action of HePC: the bases for membrane selectivity and as a membrane perturbator agent. We explored the interaction of HePC with lipid monolayers and bilayer vesicles, combining monolayer penetration experiments, Brewster angle microscopy and differential scanning calorimetry. Several membrane compositions were tested to explore different rheological conditions, phase states and lateral structures. Additionally, the kinetics between the soluble and the membrane form of HePC was explored. Our results showed an increase in elasticity induced by ...
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A comparative study on the efficacy of combination therapy with Omeprazole and low dose systemic Meglumine Antimoniate (Glucantime) and the full dose systemic Meglumine Antimoniate in the treatment of cutaneous ...
Enteric parasitic diseases including giardiasis are of public health concern. Different methods are available for the diagnosis of this parasitic infection in fecal samples such as the identification of protozoan cysts and trophozoites by light microscopy, detection of specific antigens by ELISA, and amplification of DNA fragments by PCR. The present study aimed at assessing the performance of four laboratory tests for the detection of Giardia duodenalis in fecal specimens from three different host species with a previous diagnosis of giardiasis; canine, feline and human patients provided new stool samples to be retested for Giardia before initiating treatment with antiprotozoal drugs ...
Rolitetracycline, a derivative of tetracycline, is a broad-spectrum antibiotic. Rolitetracyclin has a role as a protein synthesis inhibitor, an antiprotozoal drug and a prodrug. - Mechanism of Action & Protocol.
Ornidazole is an anti-infective, antibacterial and antiprotozoal drug. For effective relief of numerous infections, order Ornidazole today and experience better health!Ornidazole is als...
Ten Leishmania isolates (L. infantum: 6 isolates, L. donovani, L. tropica, L. major, L. aethiopica: one isolate each) have been successfully adapted to grow as axenic amastigote or amastigote-like forms. Promastigote forms were propagated in vitro (27oC, pH 7.2) in a defined liquid medium requiring no serum or serum substitutes at. Amastigotes forms were cultivated in a slightly modified medium [1] substituted with 1% of a commercially available serum fraction produced from abundantly available adult bovine serum (FC III, HyClone) which obviates the need for fetal bovine serum. Axenic amastigotes were produced from promastigotes by increasing the temperature stepwise to 36oC followed by decreasing the pH of the medium stepwise to 5.4 [2 ...
From soil samples collected in the jungles of Ninh Binh Province of the Vietnamese Democratic Republic, 97 isolates belonging to 54 species of Fungi imperfecti were obtained and screened for the produ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Javier D. Murillo is the author of this article in the Journal of Visualized Experiments: Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
Adriana M. Restrepo is the author of this article in the Journal of Visualized Experiments: Kutan leishmaniasis i den dorsale hud af hamstere: en nyttig model til screening af Antileishmanial Drugs
Flagyl is an antiprotozoal and antibacterial drug to treat infections caused by anaerobic bacterteria and certain parasites like giardia and ameba. 200/400/mg.
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Murray, PJ; Kranz, M; Ladlow, M; Taylor, S; Berst, F; Holmes, AB; Keavey, KN; Jaxa-Chamiec, A; Seale, PW; Stead, P; +4 more... Upton, RJ; Croft, SL; Clegg, W; Elsegood, MRJ; (2001) The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin. Bioorganic & medicinal chemistry letters, 11 (6). pp. 773-776. ISSN 0960-894X DOI: https://doi.org/10.1016/S0960-894X(01)00049-X Full text not available from this repository ...
Microscopic examination:direct visualization of the intracellular Amastigotes (Leishman-Donovan bodies).Amastigotes( formed after the macrophage phagocytizes an infective promastigote) are seen within blood and spleen monocytes or, less commonly, in circulating neutrophils and in aspirated tissue macrophages. They are small, round bodies 2-4 μm in diameter with indistinct cytoplasm, a nucleus, and a small, rod-shaped kinetoplast ...
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A coccidiostat is an antiprotozoal agent that acts upon Coccidia parasites. Examples include: Amprolium Arprinocid Artemether ... MeSH list of agents 82003049 v t e. ...
Imidazoles devoid of the nitro group no longer have any antiprotozoal activity, however, such drugs are effective antifungal ... agents. Alkylation of imidazole (2) with bromoketone (1) prepared from o,p-dichloroacetophenone affords the displacement ... Sunderland MR, Cruickshank RH, Leighs SJ (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of ...
Saponins are also natural ruminal antiprotozoal agents that are potential to improve ruminal microbial fermentation reducing ... other agents are now preferred[citation needed]) and arrhythmia. These sweet glycosides found in the stevia plant Stevia ...
... is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with ...
Animal models suggest lupeol may act as an anti-inflammatory agent. A 1998 study found lupeol to decrease paw swelling in rats ... Lupeol has a complex pharmacology, displaying antiprotozoal, antimicrobial, antiinflammatory, antitumor and chemopreventive ... As an anti-inflammatory agent, lupeol functions primarily on the interleukin system. Lupeol to decreases IL-4 (interleukin 4) ...
Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad- ... The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase ( ... Agents Chemother. 46 (7): 2116-23. doi:10.1128/aac.46.7.2116-2123.2002. PMC 127316 . PMID 12069963. Nitazoxanide (NTZ) is a ... Rossignol JF (October 2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. 110: 94-103. doi: ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ...
antiprotozoal agent, Emesis Ergot alkaloids Vasoconstriction, hallucinogenic, Uterotonic Morphine analgesic Nicotine stimulant ... Int J Antimicrob Agents. 44 (5): 377-386. doi:10.1016/j.ijantimicag.2014.06.001. PMID 25130096.. ... The newer semi-synthetic chemotherapeutic agent vinorelbine is used in the treatment of non-small-cell lung cancer.[134][195] ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ... Cutting agent[edit]. Quinine is sometimes detected as a cutting agent in street drugs such as cocaine and heroin.[63] ... As a flavoring agent in beverages, quinine is limited to less than 83 parts per million in the United States, and 100​mg⁄l in ... Magill A, Panosian C (July 2005). "Making antimalarial agents available in the United States". The New England Journal of ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ... 1950). "Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report". Journal National Malaria Society. 9 ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ... It is also recommended by the Infectious Disease Society of America for malaria prophylaxis as a first or second-line agent, ...
... including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of infection, the antibiotic may be ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... The top three single agent/disease killers are HIV/AIDS, TB and malaria. While the number of deaths due to nearly every disease ... In this case, xenodiagnosis involves the use of the vector of the Chagas agent T. cruzi, an uninfected triatomine bug, which ...
See also: Antiprotozoal agent and Apicomplexa § Parasitology_and_genomics. Some protists are significant parasites of animals ( ...
Gonçalves AQ, Viana Jda C, Pires EM, Bóia MN, Coura JR, Silva EF (2007). "The use of the antifungal agent miconazole as an ... The reduction in the availability of antiprotozoal drugs has been noted as a complicating factor in treatment of other ... Zierdt CH, Swan JC, Hosseini J (1983). "In vitro response of Blastocystis hominis to antiprotozoal drugs". J. Protozool. 30 (2 ... Stovarsol and Narsenol, two arsenic-based antiprotozoals, were reported to be effective against the infection. Carbarsone was ...
"Antimicrobial Agents and Chemotherapy. 45 (3): 649-59. doi:10.1128/aac.45.3.649-659.2001. PMC 90351 . PMID 11181338.. ... A limited number of antibiotics also possess antiprotozoal activity.[3][4] Antibiotics are not effective against viruses such ... "Antimicrobial Agents and Chemotherapy. 51 (12): 4255-60. doi:10.1128/AAC.00824-07. PMC 2167999 . PMID 17923487.. ... "Antimicrobial Agents and Chemotherapy. 58 (8): 4573-82. doi:10.1128/AAC.02463-14. PMC 4135978 . PMID 24867991.. ...
Biocidal substances and products are also employed as anti-fouling agents or disinfectants under other circumstances: chlorine ... An antimicrobial: this includes germicides, antibiotics, antibacterials, antivirals, antifungals, antiprotozoals, and ... preservatives and colouring agents. Since these substances may act together to produce a combination effect, an assessment of ...
Agents Chemother. 10 (2): 234-40. doi:10.1128/aac.10.2.234. PMC 429727. PMID 185949. GHOLZ LM, ARONS WL (1964). "Prophylaxis ... Clioquinol's use as an antiprotozoal drug has been restricted or discontinued in some countries due to an event in Japan where ... Clioquinol (iodochlorhydroxyquin) is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member ... Several recently reported journal articles describing its use as an antiprotozoal include: A 2005 reference to its use in ...
... anticestodal agents MeSH D27.505.954.122.250.075.100.750 - schistosomicides MeSH D27.505.954.122.250.100 - antiprotozoal agents ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Antiprotozoal activity[edit]. Researchers are investigating the use of protease inhibitors developed for HIV treatment as anti- ... "Antimicrobial Agents and Chemotherapy. 51 (11): 3932-9. doi:10.1128/AAC.00436-07. PMC 2151429. PMID 17698625.. ... Agents Chemother. 50 (2): 639-48. doi:10.1128/AAC.50.2.639-648.2006. PMC 1366900. PMID 16436721.. ... "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents" (PDF). Developed by the DHHS Panel on ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... antiprotozoals, probiotics, prebiotics, antitoxins and antivenoms. ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
"Agents Classified by the IARC Monographs, Volumes 1-124". International Agency for Research on Cancer (IARC). 8 July 2019. ... Metronidazole, marketed under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. It is used ... 2007). "Pharmaceutical agents known to produce disulfiram-like reaction: effects on hepatic ethanol metabolism and brain ... The metabolites show antibiotic and antiprotozoal activity in vitro. Metronidazole and its metabolites are mainly excreted via ...
383-. ISBN 978-0-323-14465-0. Ray S, Sharma I (1987). "Development of progesterone antagonists as fertility regulating agents ... and so lanosterol 14α-demethylase inhibitors are used as antifungals and antiprotozoals in the treatment of infections. ...
Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These ...
Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or ... When choosing analgesics, the severity and response to other medication determines the choice of agent; the World Health ...
List of agents[edit]. Adrenaline releasing agents[edit]. Main article: Norepinephrine releasing agent ... 3 List of agents *3.1 Adrenaline releasing agents *3.1.1 Common or widely marketed ... since these agents lose effectiveness after a few days. ...
"Dermatotherapeutic Agents". Ullmann's Encyclopedia of Industrial Chemistry (7th ed.). 2007. doi:10.1002/14356007.a08_301.pub2. ... Kyriakidis I, Tragiannidis A, Munchen S, Groll AH (February 2017). "Clinical hepatotoxicity associated with antifungal agents ... "The cost effectiveness of testing for onychomycosis versus empiric treatment of onychodystrophies with oral antifungal agents ... "Current and emerging azole antifungal agents". Clinical Microbiology Reviews. 12 (1): 40-79. PMC 88906. PMID 9880474 ...
Within the class of medications, there is no clear evidence that one agent works better than another.[1][2] ... In British Columbia, Canada the cost of the PPIs varies significantly from 0.20 CAD to 2.38 CAD per dose while all agents in ... The cost between different agents varies significantly.[1] ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... antiprotozoals, probiotics, prebiotics, antitoxins and antivenoms. ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
It may be used as a nasal/sinus decongestant, as a stimulant,[119] or as a wakefulness-promoting agent.[120] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... and anorectic agent.[112] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ... "Phenylisopropylamine stimulants: amphetamine-related agents". In Lemke TL, Williams DA, Roche VF, Zito W (eds.). Foye's ...
The disease causing agent, Histomonas meliagridis, is transmitted in the eggs of the worm Heterakis gallinarum.[7] Once in the ... Natustat and nitarsone were shown to be effective therapeutic drugs.[14] Nifurtimox, a compound with known antiprotozoal ...
Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ... Anti-microtubule agents[edit]. Vinca alkaloids prevent the assembly of microtubules, whereas taxanes prevent their disassembly ...
Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ... Antiprotozoal medicines[edit]. Antiamoebic and antigiardiasis medicines[edit]. *Diloxanide. *Metronidazole. Antileishmaniasis ... Diagnostic agents[edit]. *Tuberculin, purified protein derivative (PPD). Sera and immunoglobulins[edit]. *Antivenom ... single agent trimethoprim may be an alternative for lower urinary tract infection. ...
The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... Diuretics increase the urine volume and dilute doping agents and their metabolites. Another use is to rapidly lose weight to ... "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and ...
Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure,[56] although since cholinesterases are produced in ... Even with proper administration, it is inevitable for some diffusion of agent into the body from the site of application due to ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Agents Chemother. 12 (5): 642-6. doi:10.1128/AAC.12.5.642. PMC 429991 . PMID 303498.. ... Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, ... Virtue, RW; Alanis, JM; Mori, M; Lafargue, RT; Vogel, JH; Metcalf, DR (1967). "An anaesthetic agent: 2-orthochlorophenyl, 2- ... a PCP-receptor-acylating agent". Synapse. 1 (5): 497-504. doi:10.1002/syn.890010514. PMID 2850626.. ...
"Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review" (PDF). Respiratory Care. 60 ...
Antiprotozoals. *Anthelmintics. *Ectoparasiticides. *IVIG. *Vaccines. Malignant disease. (L01-L02). *Anticancer agents * ...
LDL-lowering potency varies between agents. Cerivastatin is the most potent, (withdrawn from the market in August, 2001 due to ... Thurnher M, Nussbaumer O, Gruenbacher G (July 2012). "Novel aspects of mevalonate pathway inhibitors as antitumor agents". ... The first agent they identified was mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum. ... Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005, ...
... "centrally acting agents",[10] but adds a distinct category of "directly acting agents", for dantrolene.[11] Use of this ... Several of these agents also have abuse potential, and their prescription is strictly controlled.[22][23][24] ... However, it is now known not every agent in this class has CNS activity (e.g. dantrolene), so this name is inaccurate.[5] ... "M03B Muscle Relaxants, Centrally acting agents". ATC/DDD Index. WHO Collaborating Centre for Drug Statistics Methodology.. ...
View list of generic drugs that are classified under Antiprotozoal Agents, Amebicides along with ICD Code. Find related ... Antiprotozoal Agents, Amebicides. ICD Code -Y41.3 Diloxanide This medication is an anti-protozoal agent, prescribed for ...
... and antiprotozoal agents for Toxoplasmosis and Neosporosis. For many degenerative neuropathies there is no treatment however ...
Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) ... Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) ... These data demonstrated that non-dihydropyridine-CCBs present antiprotozoal activity and could be useful candidates for future ... Except for amrinone, our results demonstrated antiprotozoal activity for fendiline, mibefradil, and lidoflazine, with IC50 ...
Nidazol is an antiprotozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive ... Nidazol is an antiprotozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive ...
Antiprotozoal agent.. *Antibacterial. Plays a role in the sponge antibacterial defense.. Product References. *A novel ... Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A: G.R. Pettit, et al.; Oncol. ...
"Antiprotozoal Agents", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Child", "type ...
Trypanocidal/ antiprotozoal agent:. Aqueous extract of Acalypha hispida leaves suggest trypanocidal effect. ...
Antiprotozoal drug , Brobenzoxaldine , CAS [3684-46-6] , Axon 2804 , Axon Ligand™ with >99% purity available from supplier Axon ... Miscellaneous Antiprotozoal agents Antiprotozoal drug Chemical name. 5,7-Dibromo-2-methylquinolin-8-yl benzoate ... Broxaldine is an antiprotozoal drug.. KEYWORDS: Broxaldine , supplier , Antiprotozoal drug , Brobenzoxaldine , CAS [3684-46-6 ...
Antiprotozoal agents. Class Summary. These agents are used to treat infections caused by the protozoan T cruzi. ... The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005 Jul 15. 309(5733):409-15. [Medline] ...
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents. Cary F. C. Lam 1, A. Norrie Pearce 1, Shen H. Tan 1,†, ... Table 1. Anti-protozoal, cytotoxic activities and clogP values of 2-4, 7a-h, j, 8a-k.. Entry. Compound. IC50 (μM) a. SI Pf g. ... Table 2. Anti-protozoal and cytotoxic activities of 10a/10b, 11a/11b, 12, 15-17.. Entry. Compound. IC50 (μM) a. SI Pf g. clogP ... Table 1. Anti-protozoal, cytotoxic activities and clogP values of 2-4, 7a-h, j, 8a-k. ...
Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) ... "Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) ...
... and correct diagnosis for Antiprotozoal agent-induced liver damage signs or Antiprotozoal agent-induced liver damage symptoms. ... Symptoms of Antiprotozoal agent-induced liver damage including 16 medical symptoms and signs of Antiprotozoal agent-induced ... Do I have Antiprotozoal agent-induced liver damage? *Antiprotozoal agent-induced liver damage: Introduction *Antiprotozoal ... Treatments for Antiprotozoal agent-induced liver damage *More about Antiprotozoal agent-induced liver damage Antiprotozoal ...
Antiprotozoals Brokerage service for pharmaceutical and parapharmaceutical products active ingredients and precursors.. ... Agents acting on the renin-angiot.. Ace inhibitors, plain Ace inhibitors, plain ... Beta blocking agents Beta blocking agents Beta blocking agents, non-selecti.. Beta blocking agents, selective ... Agents against amoebiasis and other protozoal diseases , ... Lipid modifying agents Lipid modifying agents, plain Hmg coa ...
... Our company offers the ... Synthesis of 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents. Our company offers the ... Synthesis of 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents. /technology-offers/6000/ ... Synthesis of 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents. ...
A newer agent, nitazoxanide, which has both anthelmintic and antiprotozoal activity, is discussed. The chapter also reviews ... There are a number of effective antiprotozoal and anthelmintic drugs currently available. These antiparasitic agents are ... The two agents used for treatment of American trypano-somiasis are nifurtimox and benznidazole. Nifurtimox has significant side ... Benznidazole crosses the placenta, but there are minimal data regarding teratogenic effects of either agent in either animals ...
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For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus ...
For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease ...
Chiniofon is an antiprotozoal agent. "Chiniofon". WHO Collaborating Centre for Drug Statistics Methodology. Leake CD (December ...
Teclozan is an antiprotozoal agent. It is a dichloroacetamide. Slighter RG, Yarinsky A, Drobeck HP, Bailey DM (August 1980). " ... "Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal ...
Antiprotozoal Agents Research. [x] Remove Focus on Antiprotozoal Agents. Filter by Study Type. Animal Study. ...
... attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. We ... showed the more significant antiprotozoal activity (91.54% and 90.50% growth inhibition at a concentration of 150 µg/mL with ... used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal ... antiprotozoal agents; 1D- and 2D-NMR data neglected diseases; amoebiasis; Mexican medicinal plants; bioguided isolation; ...
Antifungal agents. Antileprosy agents. Antimalarial agents. Antiprotozoal agents. Antitubercular agents --. 2. Agents affecting ... Antifungal agents. Antileprosy agents. Antimalarial agents. Antiprotozoal agents. Antitubercular agents -- 2. Agents affecting ... Oxytocic agents --. 9. Homeostatic and nutrient agents: Agents used to treat hyperglycemia. Vitamins --. 10. Agents used to ... Oxytocic agents -- 9. Homeostatic and nutrient agents: Agents used to treat hyperglycemia. Vitamins -- 10. Agents used to treat ...
It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and ... Antiprotozoal agents. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. ... Int J Antimicrob Agents 2005; 26: 176-8. [PubMed: 16009537]. (50 year old woman developed jaundice four days after starting ... There does not seem to be cross reactivity to hepatic injury among the various antimalarial agents and switching to other drug ...
Anti-Infective Agents. Anti-Bacterial Agents. Antiprotozoal Agents. Antiparasitic Agents. Protein Synthesis Inhibitors. Enzyme ...
Antiprotozoal Agents. Antiparasitic Agents. Anti-Infective Agents. Antifungal Agents. Coccidiostats. Schistosomicides. ... Both compounds are effective as single agents. However, recrudescence is common with artemether and lumefantrine has a slow ...
Anti-Infective Agents. Antimalarials. Antiprotozoal Agents. Antiparasitic Agents. Folic Acid Antagonists. Enzyme Inhibitors. ...
Antiprotozoal Agents. Antiparasitic Agents. Anti-Infective Agents. Folic Acid Antagonists. Enzyme Inhibitors. Molecular ... Anti-Infective Agents, Urinary. Renal Agents. Anti-Dyskinesia Agents. Cytochrome P-450 CYP2C8 Inhibitors. Cytochrome P-450 ... Antimicrob Agents Chemother. 2013 Sep;57(9):4245-4251. doi: 10.1128/AAC.00161-13. Epub 2013 Jun 24. ... Antimicrob Agents Chemother. 2015;59(6):3018-30. doi: 10.1128/AAC.05141-14. Epub 2015 Mar 9. ...
Antiprotozoal Agents / therapeutic use * Dog Diseases / prevention & control* * Dogs * Fluorescent Antibody Technique ...
Antiprotozoal Agents / administration & dosage* * Antiprotozoal Agents / pharmacology * Cells, Cultured * Cytokines / ...
Class: Antiprotozoals, Miscellaneous. - Antiprotozoal Agents. VA Class: AM900. CAS Number: 443-48-1. Brands: Flagyl ... Susceptibility of Mobiluncus species to 23 antimicrobial agents and 15 other compounds. Antimicrob Agents Chemother. 1987; 31: ... Susceptibility of Propionibacterium acnes clinical isolates to 22 antimicrobial agents. Antimicrob Agents Chemother. 1983; 23: ... Antibacterial and antiprotozoal;.152 197 430 494 495 nitroimidazole derivative.494. Uses for Metronidazole Hydrochloride. Bone ...
Antiprotozoal agent: Amebicide. Chemical Names. α,2-Dimetyl-5-nitroimidazole-1-etanol (WHO) ...
Non-HIV Antiviral Agents.- Antifungal Agents.- Antimalarial Agents.- Antiprotozoal and Antithelmintic Agents.- Drug ... Antiprotozoal and Antithelmintic Agents10. Glycopeptides and Lipopeptides11. Tetracyclines, Aminoglycosides and Miscellaneous ... a valuable text for all practitioners involved in using anti-infective agents...provide[s] insight into the very important ...
Chemotherapeutic agents; Antibiotics; antimycobacterial drugs; antimycotic drugs; antiprotozoal drugs; antiviral agents; ... Steroid hormones (glucocorticoids, mineralocorticoids, estrogens, progestins and androgens) and related therapeutic agents. ...
Sodium Gluconate :: pharmacology; Antiprotozoal Agents ::. pharmacology; Cell Line; Chromatography, Ion Exchange; Cresols ::. ... Antimicrob Agents Chemother. 1993 Sep ;37 (9):1842-6 8239593. (P,S,G,E,B). W L Roberts, P M Rainey. Department of Laboratory ...
Although all infectious agents in humans are parasites, by convention, parasitic diseases are defined as those caused by ... Tinidazole: a nitroimidazole antiprotozoal agent. Clin Ther. Dec 2005. 27:1859-84. [Medline]. ... Symptoms usually resolve within 3-4 days after initiation of antiprotozoal therapy in immunocompetent patients with protozoal ... This is an illustration of the life cycle of Isospora belli, the causal agent of isosporiasis. ...
Pharmacological Actions : Antiparasitic Agents, Antiprotozoal Agents. Additional Keywords : Essential Oils. [+] Red propolis ... Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 ... Pubmed Data : Antimicrob Agents Chemother. 2018 Jul 9. Epub 2018 Jul 9. PMID: 29987143 ...
  • Except for amrinone, our results demonstrated antiprotozoal activity for fendiline, mibefradil, and lidoflazine, with IC50 values in a range between 2 and 16 mu M and Selectivity Index between 4 and 10. (fapesp.br)
  • These data demonstrated that non-dihydropyridine-CCBs present antiprotozoal activity and could be useful candidates for future in vivo efficacy studies against Leishmaniasis and Chagas' disease. (fapesp.br)
  • Antimicrobial (including antibiotics, antivirals, antifungal and antiprotozoal) agents are critical to fight diseases in humans, animals and plants, but misuse and overuse is making an increasing number of them ineffective. (hindustantimes.com)
  • Metronidazole, an antibiotic and antiprotozoal agent that as a topical preparation is used to treat the inflammatory lesions and erythema of rosacea. (patientslikeme.com)
  • This medication is an anti-protozoal agent, prescribed for intestinal amoebiasis. (medindia.net)
  • The chapter also reviews other major antiprotozoal drugs, including those used for malaria, gastrointestinal protozoal infection, leishmaniasis, and trypanosomiasis. (asmscience.org)
  • Symptoms usually resolve within 3-4 days after initiation of antiprotozoal therapy in immunocompetent patients with protozoal gastroenteritis. (medscape.com)
  • Antiprotozoals are used to study the various complications of protozoal infections. (scbt.com)
  • Because there is so much variation between protozoal species, antiprotozoals can be highly specific and rely on differing mechanisms of action. (scbt.com)
  • Treatment includes anti-protozoal agents. (reportsweb.com)
  • Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (labome.org)
  • vivax and P. Mechanism of Action: Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. (musicaenlamochila.net)
  • Plants or their extracts with high concentrations of saponins appear to have the potential to act as natural antiprotozoal agents ( Patra and Saxena, 2009a ). (frontiersin.org)
  • Flavonoids, including aurones, pterocarpanes, and lignans, structural analogues of coumaranes, are abundant in fruits and vegetables, so these phytophenolics may act as natural antiprotozoal agents in humans. (usda.gov)
  • Chloroquine has been replaced by hydroxychloroquine as an antiinflammatory agent in rheumatic diseases, and these are unapproved, off-label uses. (nih.gov)
  • No chemoprophylactic agents are available for any of these diseases. (medscape.com)
  • Because of the side-effects and the resistance that pathogenic protozoa build against the standard antiparasitic drugs, e.g., metronidazole, much recent attention has been paid to plants used in traditional medicine around the world in order to find new antiprotozoal agents. (mdpi.com)
  • Antiprotozoals are drugs that prevent growth of or kill protozoa. (neli.org.uk)
  • Antiprotozoal agents: The protozoa causing eye infections can be used along with furazolidone. (yogachicago.com)
  • Part 4 'Therapeutic use of antimicrobial agents' provides advice about the treatment of common infections which are described by anatomical. (oup.com)
  • However, this clinical mixing, and its in vitro surrogate, has generally been conducted with agents already known to be effective in the therapeutic area of interest, or where there is a clear rationale for the combination. (pnas.org)
  • Our company offers the chemical optimization service - synthesis of a unique 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives for your biological projects, related to developing of antiprotozoal drugs. (innoget.com)
  • Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents. (alfa.com)
  • The acute antiprotozoal effect of hederagenin derivatives was more pronounced than that of cholesterol and cholic acid derivatives. (frontiersin.org)
  • Nitazoxanide is in a class of medications called antiprotozoal agents. (medlineplus.gov)
  • Mechanism of action Nitazoxanide, a synthetic antiprotozoal agent. (salespider.com)
  • These agents are used to treat infections caused by the protozoan T cruzi . (medscape.com)
  • Antimalarial agents. (worldcat.org)
  • There does not seem to be cross reactivity to hepatic injury among the various antimalarial agents and switching to other drug can be done. (nih.gov)
  • However, if pfmdr-1 en- codes a transport protein that promotes the uptake of chloroquine into the digestive vac- uole, it differenh be ai-gued that decreased expres- sion of pfmdr~l would give rise to resistance. (oilforexprofits.com)
  • They may therefore act at 5-HT(3) receptors Mefloquine, like chloroquine and quinine, is a blood schizonticidal agent and is active against the intraerythrocytic stages of parasite development. (schule.de)
  • Non-HIV Antiviral Agents. (indigo.ca)
  • Entecavir is an oral antiviral agent, prescribed for hepatitis B. (medindia.net)
  • Part 1 'General property of antimicrobial agents' discusses mechanisms of action and resistance to antibacterial, antifungal antiprotozoal, antiviral, and antiviral agents. (oup.com)
  • A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C. (thefreedictionary.com)
  • Metronidazole is an antiprotozoal and anaerobic antibacterial agent. (dermnetnz.org)
  • A recent paper from the Journal of Medicinal Chemistry* showed that authors designed and synthesized a series of imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which they identified recently. (innoget.com)
  • Nithiazide, a synthetic antiprotozoal agent, was first produced in 1961. (inchem.org)
  • a valuable text for all practitioners involved in using anti-infective agents. (indigo.ca)
  • Therefore, there is an speedy need to develop new antiprotozoal drugs. (innoget.com)
  • There are a number of effective antiprotozoal and anthelmintic drugs currently available. (asmscience.org)
  • used parenterally as backup drugs for tx of severe intestinal or hepatic amebiasis together with a luminal agent in hospitalized pts. (flashcardmachine.com)
  • These antiparasitic agents are important both for therapy of individual patients and for control of parasitic infections at the community level. (asmscience.org)
  • Outpatient medications: Oral antiprotozoal therapy is usually administered at home. (medscape.com)
  • Atovaquone, an antiprotozoal and antipneumocystic agent, is predominantly cleared by biliary excretion of unchanged parent drug. (aspetjournals.org)
  • Tenofovir is a class of antiretroviral agent, prescribed for HIV infection in combination with other medicines, and chronic hepatitis B in adults. (medindia.net)
  • Part 3 'General principles of usage of antimicrobial agents' analyses the use of the laboratory, general principles of the treatment of infection, dosing in special groups (extremes of age, pregnancy, obesity), safe prescribing, prophylaxis and the role of policies in antimicrobial stewardship. (oup.com)
  • However, infection with this agent is uncommon. (rehydrate.org)
  • these latter features suggest infection with a bacterial agent that invades the intestinal mucosa (such as C. jejuni or Shigella ), but alone are not sufficient to diagnose dysentery. (rehydrate.org)
  • The most common agents associated with gastrointestinal infections are the bacteria Escherichia coli, Salmonella typhi, and Shigella spp. (scirp.org)
  • Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. (oup.com)
  • It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. (nih.gov)
  • Bioassay-guided fractionation of the methanolic extracts from these two plants afforded carvacrol ( 1 ) and chalepensin ( 2 ), respectively, as bioactive compounds with antiprotozoal activity. (mdpi.com)
  • 2 Using Connectivity Map, 3 which combines the resistance gene expression signature with a database of expression profiles of bioactive small molecules, we identified several molecules as agents potentially able to reverse resistance to PUVA with or without interferon-α therapy. (haematologica.org)
  • Benznidazole crosses the placenta, but there are minimal data regarding teratogenic effects of either agent in either animals or humans. (asmscience.org)
  • We collected 32 plants used in Northeast Mexican traditional medicine and the methanolic extracts of these species were screened for antiprotozoal activity against E. histolytica trophozoites using in vitro tests. (mdpi.com)
  • The methanol extract fraction containing ursolic acid obtained from Thymus vulgaris has antiprotozoal activity against G. lamblia and T. vaginalis trophozoites. (scirp.org)
  • Metronidazole (C 6 H 9 N 3 O 3 ) is an antibacterial and antiprotozoal agent that has gained widespread use as a drug . (everything2.com)
  • For the group of 110 patients, regimens combining (the already failed) nitroimidazoles with other agents led to a cure rate of 86.1% ( Table 2 ). (cdc.gov)
  • Imidazole-based compounds show good antiprotozoal activity. (innoget.com)
  • Alkylating agents, antimetabolities, hormones and other antineoplastic compounds. (edu.sa)
  • The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumaranes and aurones, remained active. (usda.gov)
  • The current antiprotozoal therapies are unsatisfactory due to their low efficacy, high toxicity and appearance of resistant parasitic strains. (innoget.com)
  • Drug treatments included antispasmodic therapies, selective serotonin reuptake inhibitors and antibacterial and antiprotozoal agents, but these were reported to provide little relief. (vitamindcouncil.org)
  • Juliana Quero Reimão, Juliana Tonini Mesquita, Daiane Dias Ferreira, and Andre Gustavo Tempone, "Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum ," Evidence-Based Complementary and Alternative Medicine , vol. 2016, Article ID 1523691, 9 pages, 2016. (hindawi.com)
  • Endovascular chemoembolization is the method of simultaneously administer- ing into the blood vessel of the tumor tissue the vascular occlusion materials and anti- tumor agents that block the supply of nutrients to diffeerent tumor tissue as well type contribute cytotoxic action stick the anticancer agents. (oilforexprofits.com)
  • Part 2 'Resistance to antimicrobial agents' provides guidance about the problem of resistance, mechanisms of acquired resistance and genetics of resistance. (oup.com)
  • Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. (nih.gov)
  • Ursodeoxycholic Acid is a biliary agent, prescribed for gallstones. (medindia.net)
  • 5. Gastrointestinal agents: Agents used to treat acid peptic disorders. (worldcat.org)
  • 7. Hormones and agents affecting hormonal mechanisms: Adrenal corticosteroids. (worldcat.org)
  • The symptom information on this page attempts to provide a list of some possible signs and symptoms of Antiprotozoal agent-induced liver damage . (rightdiagnosis.com)
  • This signs and symptoms information for Antiprotozoal agent-induced liver damage has been gathered from various sources, may not be fully accurate, and may not be the full list of Antiprotozoal agent-induced liver damage signs or Antiprotozoal agent-induced liver damage symptoms. (rightdiagnosis.com)
  • Furthermore, signs and symptoms of Antiprotozoal agent-induced liver damage may vary on an individual basis for each patient. (rightdiagnosis.com)
  • Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Antiprotozoal agent-induced liver damage symptoms. (rightdiagnosis.com)
  • Metadoxine is a hepatoprotective agent, prescribed for the treatment of fatty liver due to alcoholism. (medindia.net)