Antiplatyhelmintic Agents: Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.Artemisinins: A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).Antimalarials: Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)Fluorenes: A family of diphenylenemethane derivatives.Cameroon: A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.Apiaceae: A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.Acorus: A plant genus of the family ACORACEAE, order Arales, subclass Arecidae most notable for Acorus calamus L. root which contains asarone and has been used in TRADITIONAL MEDICINE.Pimenta: A plant genus in the family MYRTACEAE, order Myrtales, subclass Rosidae. It is best known for allspice from the dried berry of Pimenta diocia.Piper nigrum: A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. Piperine is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.Myrtaceae: The myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.Acoraceae: A plant family of the order Arales, subclass Arecidae, class Liliopsida (monocot).Black Pepper: A common spice from fruit of PIPER NIGRUM. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water. Piperine is a key component used medicinally to increase gastrointestinal assimilation of other supplements and drugs.Diagnosis-Related Groups: A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Dry Eye Syndromes: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Tears: The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.Accidents
Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (1/35)AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug. (+info)
Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits. (2/35)To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific. (+info)
Case studies in international medicine. (3/35)Family physicians in the United States are increasingly called on to manage the complex clinical problems of newly arrived immigrants and refugees. Case studies and discussions are provided in this article to update physicians on the diagnosis and management of potentially unfamiliar ailments, including strongyloidiasis, hookworm infection, cysticercosis, clonorchiasis and tropical pancreatitis. Albendazole and ivermectin, two important drugs in the treatment of some worm infections, are now available in the United States. (+info)
Bioavailability of praziquantel increases with concomitant administration of food. (4/35)In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively. (+info)
In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts. (5/35)We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ. (+info)
Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. (6/35)Fasciola hepatica, an endemic parasite in Turkey, is still a very rare cause of cholestasis worldwide. Through ingestion of contaminated water plants like watercress, humans can become the definitive host of this parasite. Cholestatic symptoms may be sudden but in some cases they may be preceded by a long period of fever, eosinophilia and vague gastrointestinal symptoms. We report a woman with cholangitis symptoms of sudden onset which was proved to be due to Fasciola hepatica infestation by an endoscopic retrograde cholangiography. (+info)
The research on biotransformation of praziquantel. (7/35)Praziquantel (PZQ), a broad spectrum antihelmintic drug, is extensively metabolized in the liver, yielding mainly monohydroxylated and dihydroxylated phase-I-metabolites. However, the exact chemical structures of the most metabolites are still unknown. In the presented research, three types of PZQ biotransformations were performed: biotransformation with the whole cells of Saccharomyces cerevisiae, with cytochrome c from Saccharomyces cerevisiae and with microsomes isolated from Saccharomyces cerevisiae. To describe the obtained metabolites TLC, RP-TLC, and HPLC were used. (+info)
Artesunate and artemether are effective fasciolicides in the rat model and in vitro. (8/35)OBJECTIVES: To study the fasciocidal properties of artesunate and artemether in the rat model and in vitro. METHODS: Adult Fasciola hepatica were exposed in vitro to 1, 10 and 100 microg/mL of artesunate, artemether and dihydroartemisinin for 72 h. Female Wistar rats were administered a single oral dose of artesunate and artemether (100-400 mg/kg) commencing 3 or 10-14 weeks post-infection and worm burden reductions were assessed against infected but untreated control rats. F. hepatica were also observed by scanning electron microscopy (SEM) after recovery from bile ducts of rats given a single oral dose of 200 mg/kg artesunate 24 and 72 h post-treatment. RESULTS: F. hepatica exposed for 72 h to 10 microg/mL of artesunate, artemether and dihydroartemisinin in vitro showed poor mobility, swelling of the worm body, roughness, damage of the tegument and blebbing. Exposure to drug concentrations of 100 microg/mL resulted in the death of all F. hepatica by 72 h. One hundred per cent worm burden reductions were achieved in rats infected with adult F. hepatica after treatment with artesunate and artemether at 400 and 200 mg/kg, respectively. Administration of artesunate and artemether at a dose of 200 mg/kg to rats harbouring juvenile F. hepatica resulted in worm burden reductions of 46% and 82%, respectively. F. hepatica recovered from rats' bile ducts 24 h after administration of 200 mg/kg artesunate showed normal activity and SEM observations revealed that there was no visible damage. Seventy-two hours post-treatment F. hepatica displayed very poor mobility and there was focal swelling of the tegument and spines. CONCLUSIONS: Artesunate and artemether exhibit promising fasciocidal activities, with the latter showing better tolerability by the hosts. (+info)
An antiplatyhelmintic agent is a type of anthelmintic designed to reduce flatworm infection. antiplatyhelmintic agents at the ...
List of MeSH codes (D16)
... antiplatyhelmintic agents MeSH D27.505.954.122.250.075.100.040 --- anticestodal agents MeSH D27.505.954.122.250.075.100.750 ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...
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Oxidative and Nitrative Stress in Opisthorchis viverrini-Infected Hamsters: An Indirect Effect after Praziquantel Treatment |...
Praziquantel causes adverse effects after short-term treatment. To examine the mechanism of these effects, we studied the distribution of Opisthorchis viverrini antigens and the expression of inducible nitric oxide synthase (iNOS), nuclear factor-κB (NF-κB), and antioxidant enzymes in O. viverrini-infected hamsters during short-term praziquantel treatment. Praziquantel-induced dispersion of parasite antigens produced a recruitment of inflammatory cells. NF-κB and iNOS mRNA expression was significantly elevated and associated with their immunoreactivity in the bile duct epithelium and inflammatory cells. Plasma nitrate, end products of nitric oxide, and malondialdehyde level increased significantly. Expression of mRNA for antioxidant enzymes (superoxide dismutases, catalase, and glutathione peroxidase) also increased significantly, which suggests host defense against oxidative stress. These results suggest that short-term praziquantel treatment induces inflammation and resulting oxidative and
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The four Ugi products ([http://www.ourexperiment.org/racemic_pzq/4029/Preparation_of_the_PZQ_peptide_acetal_Ugiintermediate_KAB52.html KAB5-2], [http://www.ourexperiment.org/racemic_pzq/5642/Preparation_of_the_dimethoxy_Ugiintermediate_MNR85.html MNR8-5], [http://www.ourexperiment.org/racemic_pzq/1555/Preparation_of_the_Nbenzoylprotected_Ugiintermediate_MW511.html MW51-1], [http://www.ourexperiment.org/racemic_pzq/4011/Preparation_of_the_dimethoxy_Ugiintermediate_MNR102.html MNR10-2]) were subjected to varying loading levels of methanesulfonic acid to study its effect on the cyclisation. Initially the reactions were carried out in neat acid using 100 equivalents. The reaction to afford PZQ ([http://www.ourexperiment.org/racemic_pzq/2443/Acidmediated_PictetSpengler_of_MW29_to_give_racPZQ_MNR131.html MNR13-1]) was the only one that did not give clean conversion to desired product at room temperature after 1 hour but all starting material was consumed. It was however found that increasing the ...
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Sato K.; Noda S.; Miguwe D.K.; Ziro G.N.; Muhoho N.D., 1985: Epidemiological studies on schistosoma haematobium infection in coastal area kenya cercarial density at water contact points and identification of species of cercariae
A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Antiplatelet Agents (0) see Platelet Aggregation Inhibitors. Antiplatyhelmintic Agents (28) • Agents used to treat cestode, ... Anti-Mycobacterial Agents (0) see Anti-Bacterial Agents. Anti-Obesity Agents (24) • Agents that increase energy expenditure and ... Antithrombotic Agents (0) see Fibrinolytic Agents. Antithyroid Agents (10) • Agents that are used to treat hyperthyroidism by ... Antifibrillatory Agents (0) see Anti-Arrhythmia Agents. Antifibrinolytic Agents (7) • Agents that prevent fibrinolysis or lysis ...https://druginfo.nlm.nih.gov/drugportal/drug/categories
Antiplatyhelmintic agent - Wikipedia
An antiplatyhelmintic agent is a type of anthelmintic designed to reduce flatworm infection. antiplatyhelmintic agents at the ...https://en.wikipedia.org/wiki/Antiplatyhelmintic_agent
Tiabendazole - Wikipedia
Tiabendazole is also a chelating agent, which means it is used medicinally to bind metals in cases of metal poisoning, such as ... It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been ... an antifungal agent, and an antiparasitic agent. ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides) ... "Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent ...https://en.wikipedia.org/wiki/Thiabendazole
Ivermectin - Wikipedia
Ivermectin is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever. ... Thadanipon K, Anothaisintawee T, Rattanasiri S, Thakkinstian A, Attia J (2019). "Efficacy and safety of antiscabietic agents: A ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...https://en.wikipedia.org/wiki/Ivermectin
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Artemisinin-Based Antimalarial Combinations and Clinical Response in Cameroon - Full Text View - ClinicalTrials.gov
Antiparasitic Agents. Anti-Infective Agents. Antifungal Agents. Coccidiostats. Schistosomicides. Antiplatyhelmintic Agents. ... Both compounds are effective as single agents. However, recrudescence is common with artemether and lumefantrine has a slow ...https://clinicaltrials.gov/ct2/show/NCT01845701?recr=Open&cond=%22Protozoan+Infections%22&rank=19
Interactions Between Artemether-lumefantrine and Antiretrovirals in HIV-patients With Uncomplicated Malaria in Tanzania - Full...
Antiparasitic Agents. Anti-Infective Agents. Antifungal Agents. Coccidiostats. Schistosomicides. Antiplatyhelmintic Agents. ...https://clinicaltrials.gov/show/NCT00885287?order=94
Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination - Full Text View -...
Antiparasitic Agents. Anti-Infective Agents. Anthelmintics. Anticestodal Agents. Antiplatyhelmintic Agents. To Top ...https://www.clinicaltrials.gov/ct2/show/NCT01586169
Mebendazole : Wikis (The Full Wiki)
Antinematodal agents. (macrofilaricides). Binds tubulin. benzimidazole (Mebendazole#, Thiabendazole, Albendazole#, Fenbendazole ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. benzimidazole (Triclabendazole#). AI. phosphonic ...http://www.thefullwiki.org/Mebendazole
ivermectin - meddic
antiplatyhelmintic agents Antitrematodals. (schistosomicides) binds tubulin benzimidazole (Triclabendazole#) ... antinematodal agents. (macrofilaricides) binds tubulin benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ... A large international program of development resulted in the introduction of ivermectin as a commercial antiparasitic agent in ...https://meddic.jp/ivermectin
A causative agent for eye keratitis infection". Spectrochim Acta A Mol Biomol Spectrosc. 153: 714-21. doi:10.1016/j.saa.2015.09 ... White CA (2004). "Nitazoxanide: a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. 2 (1): 43-9. doi: ... Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ... Hemphill A, Mueller J, Esposito M (2006). "Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of ...https://readtiger.com/wkp/en/Antiparasitic
Desaspidin | Project Gutenberg Self-Publishing - eBooks | Read eBooks online
Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. * benzimidazole *Triclabendazole# AI. * ...http://www.self.gutenberg.org/articles/eng/Desaspidin
Subject: 'immune response' / Subject: mice / Text Availability: Citation in PubAg - PubAg Search Results
... antiplatyhelmintic agents; bacteria; cyclophilins; cyclosporine; epitopes; genes; granuloma; immunization; liver; mice; ... immune response, etc ; anaphylaxis; antigen-antibody complex; antineoplastic agents; complement; cytokines; cytotoxicity; death ...https://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=mice&f%5Btext_availability%5D%5B%5D=Citation+in+PubAg&q=%22immune+response%22&search_field=subject
Subject: 'cyclophilins' - PubAg Search Results
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diethylcarbamazine - meddic
antiplatyhelmintic agents Antitrematodals. (schistosomicides) binds tubulin benzimidazole (Triclabendazole#) ... antinematodal agents. (macrofilaricides) binds tubulin benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ...http://meddic.jp/diethylcarbamazine
A Pilot Study of Neurocysticercosis Treatment - Full Text View - ClinicalTrials.gov
Antiparasitic Agents. Anti-Infective Agents. Anticestodal Agents. Antiplatyhelmintic Agents. Antiprotozoal Agents. Tubulin ... The goal of this trial is to determine if treatment with the antiparasitic agent albendazole improves the outcome of ...https://www.clinicaltrials.gov/ct2/show/NCT00283699
PRIME PubMed | Evaluation of scolicidal agents in an experimental hydatid disease mode
PubMed journal article Evaluation of scolicidal agents in an experimental hydatid disease mode were found in PRIME PubMed. ... Anti-Infective Agents, Local. Antiplatyhelmintic Agents. Disease Models, Animal. Echinococcosis, Hepatic. Hydrogen Peroxide. ... Evaluation of Scolicidal Agents in an Experimental Hydatid Disease Model. Eur Surg Res. 1997;29(3):202-8. PubMed PMID: 9161837. ... The scolicidal agents have been, and are being used mainly during surgical manipulation of the cysts, with the object of ...https://www.unboundmedicine.com/medline/citation/9161837/Evaluation_of_scolicidal_agents_in_an_experimental_hydatid_disease_model_
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It is also being investigated as an anti-tumor agent. ... Antiplatyhelmintic Agents. *Antiprotozoals. *Carbohydrates. * ... DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents. ...https://www.drugbank.ca/drugs/DB05630
List of MeSH codes (D16) - Wikipedia
... antiplatyhelmintic agents MeSH D27.505.954.122.250.075.100.040 --- anticestodal agents MeSH D27.505.954.122.250.075.100.750 ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D16)
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Antiplatyhelmintic Agents - administration & dosage , Antiplatyhelmintic Agents - therapeutic use , Stroke - prevention & ... Antiplatyhelmintic Agents - adverse effects , Stroke (Disease) , Care and treatment , Anticoagulants (Medicine) , Patient ...https://query.library.utoronto.ca/index.php/search/q?kw=Author:Ueda,%20K
ICD-10 Diagnosis Code T37.4X1 Poisoning by anthelminthics, accidental (unintentional)
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Single-day praziquantel therapy for neurocysticercosis. - PubMed - NCBI
Antiplatyhelmintic Agents/administration & dosage*. *Brain Diseases/drug therapy*. *Cysticercosis/drug therapy*. *Drug ...https://www.ncbi.nlm.nih.gov/pubmed/8531958?dopt=Abstract
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Info Antiplatyhelmintic Agents. * Info Antiprotozoal Agents. * Info Schistosomicides. Show more categories. Show fewer ...https://druginfo.nlm.nih.gov/drugportal/unii/N116U8Y5QQ
ATCvet code QP54
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- Tiabendazole ( INN , BAN ), also known as thiabendazole ( AAN , USAN ) or TBZ and the trade names Mintezol, Tresaderm, and Arbotect, is a preservative, an antifungal agent, and an antiparasitic agent. (wikipedia.org)
- Ivermectin is a broad-spectrum antiparasitic agent. (meddic.jp)
- Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. (readtiger.com)
- The goal of this trial is to determine if treatment with the antiparasitic agent albendazole improves the outcome of neurocysticercosis infection. (clinicaltrials.gov)