Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A drive stemming from a physiological need for WATER.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Services providing pharmaceutic and therapeutic drug information and consultation.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Administrative units of government responsible for policy making and management of governmental activities.
A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
A species of parasitic nematode usually found in domestic pigs and a few other animals. Human infection can also occur, presumably as result of handling pig manure, and can lead to intestinal obstruction.
A species of EDWARDSIELLA distinguished by its nonmotility. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.
The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.
A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.
Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.
Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.
Pharmacy services accessed via electronic means.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The field of information science concerned with the analysis and dissemination of data through the application of computers.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)

Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (1/35)

AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug.  (+info)

Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits. (2/35)

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.  (+info)

Case studies in international medicine. (3/35)

Family physicians in the United States are increasingly called on to manage the complex clinical problems of newly arrived immigrants and refugees. Case studies and discussions are provided in this article to update physicians on the diagnosis and management of potentially unfamiliar ailments, including strongyloidiasis, hookworm infection, cysticercosis, clonorchiasis and tropical pancreatitis. Albendazole and ivermectin, two important drugs in the treatment of some worm infections, are now available in the United States.  (+info)

Bioavailability of praziquantel increases with concomitant administration of food. (4/35)

In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.  (+info)

In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts. (5/35)

We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.  (+info)

Fasciola hepatica infestation as a very rare cause of extrahepatic cholestasis. (6/35)

Fasciola hepatica, an endemic parasite in Turkey, is still a very rare cause of cholestasis worldwide. Through ingestion of contaminated water plants like watercress, humans can become the definitive host of this parasite. Cholestatic symptoms may be sudden but in some cases they may be preceded by a long period of fever, eosinophilia and vague gastrointestinal symptoms. We report a woman with cholangitis symptoms of sudden onset which was proved to be due to Fasciola hepatica infestation by an endoscopic retrograde cholangiography.  (+info)

The research on biotransformation of praziquantel. (7/35)

Praziquantel (PZQ), a broad spectrum antihelmintic drug, is extensively metabolized in the liver, yielding mainly monohydroxylated and dihydroxylated phase-I-metabolites. However, the exact chemical structures of the most metabolites are still unknown. In the presented research, three types of PZQ biotransformations were performed: biotransformation with the whole cells of Saccharomyces cerevisiae, with cytochrome c from Saccharomyces cerevisiae and with microsomes isolated from Saccharomyces cerevisiae. To describe the obtained metabolites TLC, RP-TLC, and HPLC were used.  (+info)

Artesunate and artemether are effective fasciolicides in the rat model and in vitro. (8/35)

OBJECTIVES: To study the fasciocidal properties of artesunate and artemether in the rat model and in vitro. METHODS: Adult Fasciola hepatica were exposed in vitro to 1, 10 and 100 microg/mL of artesunate, artemether and dihydroartemisinin for 72 h. Female Wistar rats were administered a single oral dose of artesunate and artemether (100-400 mg/kg) commencing 3 or 10-14 weeks post-infection and worm burden reductions were assessed against infected but untreated control rats. F. hepatica were also observed by scanning electron microscopy (SEM) after recovery from bile ducts of rats given a single oral dose of 200 mg/kg artesunate 24 and 72 h post-treatment. RESULTS: F. hepatica exposed for 72 h to 10 microg/mL of artesunate, artemether and dihydroartemisinin in vitro showed poor mobility, swelling of the worm body, roughness, damage of the tegument and blebbing. Exposure to drug concentrations of 100 microg/mL resulted in the death of all F. hepatica by 72 h. One hundred per cent worm burden reductions were achieved in rats infected with adult F. hepatica after treatment with artesunate and artemether at 400 and 200 mg/kg, respectively. Administration of artesunate and artemether at a dose of 200 mg/kg to rats harbouring juvenile F. hepatica resulted in worm burden reductions of 46% and 82%, respectively. F. hepatica recovered from rats' bile ducts 24 h after administration of 200 mg/kg artesunate showed normal activity and SEM observations revealed that there was no visible damage. Seventy-two hours post-treatment F. hepatica displayed very poor mobility and there was focal swelling of the tegument and spines. CONCLUSIONS: Artesunate and artemether exhibit promising fasciocidal activities, with the latter showing better tolerability by the hosts.  (+info)

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Praziquantel causes adverse effects after short-term treatment. To examine the mechanism of these effects, we studied the distribution of Opisthorchis viverrini antigens and the expression of inducible nitric oxide synthase (iNOS), nuclear factor-κB (NF-κB), and antioxidant enzymes in O. viverrini-infected hamsters during short-term praziquantel treatment. Praziquantel-induced dispersion of parasite antigens produced a recruitment of inflammatory cells. NF-κB and iNOS mRNA expression was significantly elevated and associated with their immunoreactivity in the bile duct epithelium and inflammatory cells. Plasma nitrate, end products of nitric oxide, and malondialdehyde level increased significantly. Expression of mRNA for antioxidant enzymes (superoxide dismutases, catalase, and glutathione peroxidase) also increased significantly, which suggests host defense against oxidative stress. These results suggest that short-term praziquantel treatment induces inflammation and resulting oxidative and
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... is also a chelating agent, which means it is used medicinally to bind metals in cases of metal poisoning, such as ... It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been ... an antifungal agent, and an antiparasitic agent. ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides) ... "Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent ...
... is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever.[66] ... Thadanipon K, Anothaisintawee T, Rattanasiri S, Thakkinstian A, Attia J (2019). "Efficacy and safety of antiscabietic agents: A ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...
... is a broad-spectrum antihelminthic agent of the benzimidazole type.[3] ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...
Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm ... Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...
Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...
An antiplatyhelmintic agent is a type of anthelmintic designed to reduce flatworm infection. antiplatyhelmintic+agents at the ...
... antiplatyhelmintic agents MeSH D27.505.954.122.250.075.100.040 - anticestodal agents MeSH D27.505.954.122.250.075.100.750 - ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
An antiplatyhelmintic agent is a type of anthelmintic designed to reduce flatworm infection. antiplatyhelmintic+agents at the ...
Tiabendazole is also a chelating agent, which means it is used medicinally to bind metals in cases of metal poisoning, such as ... It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been ... an antifungal agent, and an antiparasitic agent. ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides) ... "Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent ...
Ivermectin is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever.[66] ... Thadanipon K, Anothaisintawee T, Rattanasiri S, Thakkinstian A, Attia J (2019). "Efficacy and safety of antiscabietic agents: A ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. *benzimidazole *Triclabendazole#. AI. * ...
Antiparasitic Agents. Anthelmintics. Anticestodal Agents. Antiplatyhelmintic Agents. Antiprotozoal Agents. Tubulin Modulators. ... Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of Pharmacological Action. Antineoplastic Agents. Filaricides. ... Anti-Infective Agents. Spirurida Infections. Secernentea Infections. Nematode Infections. Helminthiasis. Parasitic Diseases. ...
Antiparasitic Agents. Anti-Infective Agents. Anticestodal Agents. Antiplatyhelmintic Agents. Antiprotozoal Agents. Tubulin ... There are data to suggest that infection with these agents may activate the immune system in HIV-1 co-infected individuals and ...
Antiparasitic Agents. Anti-Infective Agents. Anthelmintics. Anticestodal Agents. Antiplatyhelmintic Agents. To Top ...
Antiparasitic Agents. Anti-Infective Agents. Anticestodal Agents. Antiplatyhelmintic Agents. Antiprotozoal Agents. Tubulin ... The goal of this trial is to determine if treatment with the antiparasitic agent albendazole improves the outcome of ...
Antiparasitic Agents / pharmacology* * Antiplatyhelmintic Agents / pharmacology* * Cattle * Dose-Response Relationship, Drug * ...
28 results for Category equals ANTIPLATYHELMINTIC AGENTS Info. Please enable JavaScript in your browser. Row Number. Result. ...
Antinematodal agents. (macrofilaricides). Binds tubulin. benzimidazole (Mebendazole#, Thiabendazole, Albendazole#, Fenbendazole ... Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. benzimidazole (Triclabendazole#). AI. phosphonic ...
An antischistosomal agent that has become obsolete.. Molecular Formula. *. C6-H6-N4-O3-S ...
2014 Jun (...) 10;186(9):697 24914229 Adult Anisocoria diagnosis etiology Antiplatyhelmintic Agents therapeutic use Carotid ... C JC Sundaram Arun N E AN eng Case Reports Journal Article 2013 11 11 Canada CMAJ 9711805 0820-3946 0 Antiplatyhelmintic Agents ...
Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS. ... Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS.. ...
Antiplatyhelmintic Agents. Registry Number:. U4TFJ7GB6T CAS Type 1 Name:. Acetamide, N,N-(oxybis(2,1-ethanediyloxy-4,1- ...
antiplatyhelmintic agents Antitrematodals. (schistosomicides) binds tubulin benzimidazole (Triclabendazole#) ... antinematodal agents. (macrofilaricides) binds tubulin benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ... A large international program of development resulted in the introduction of ivermectin as a commercial antiparasitic agent in ...
A causative agent for eye keratitis infection". Spectrochim Acta A Mol Biomol Spectrosc. 153: 714-21. doi:10.1016/j.saa.2015.09 ... White CA (2004). "Nitazoxanide: a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. 2 (1): 43-9. doi: ... Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth;[4] they are usually ... Hemphill A, Mueller J, Esposito M (2006). "Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of ...
Antiplatyhelmintic agents. Antitrematodals. (schistosomicides). Binds tubulin. * benzimidazole *Triclabendazole# AI. * ...
... antiplatyhelmintic agents; bacteria; cyclophilins; cyclosporine; epitopes; genes; granuloma; immunization; liver; mice; ... immune response, etc ; anaphylaxis; antigen-antibody complex; antineoplastic agents; complement; cytokines; cytotoxicity; death ...
... antiplatyhelmintic agents; bacteria; cyclosporine; epitopes; genes; granuloma; immune response; immunization; liver; mice; ...
antiplatyhelmintic agents Antitrematodals. (schistosomicides) binds tubulin benzimidazole (Triclabendazole#) ... antinematodal agents. (macrofilaricides) binds tubulin benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ...
Aged , Antiplatyhelmintic Agents/administration & dosage , Aspirin/administration & dosage , Drug Combinations , Drug ... Animals , Antiplatyhelmintic Agents/administration & dosage , Clonorchiasis/diagnostic imaging , Clonorchiasis/prevention & ... Humans , Child , Adolescent , Adult , Antiplatyhelmintic Agents/therapeutic use , Praziquantel/therapeutic use , ... Administration, Oral , Adolescent , Adult , Antiplatyhelmintic Agents/administration & dosage , Clinical Trials as Topic , ...
PubMed journal article Evaluation of scolicidal agents in an experimental hydatid disease mode were found in PRIME PubMed. ... Anti-Infective Agents, Local. Antiplatyhelmintic Agents. Disease Models, Animal. Echinococcosis, Hepatic. Hydrogen Peroxide. ... Evaluation of Scolicidal Agents in an Experimental Hydatid Disease Model. Eur Surg Res. 1997;29(3):202-8. PubMed PMID: 9161837. ... The scolicidal agents have been, and are being used mainly during surgical manipulation of the cysts, with the object of ...
It is also being investigated as an anti-tumor agent. ... Antiplatyhelmintic Agents. *Antiprotozoals. *Carbohydrates. * ... DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents. ...
Antineoplastic Agents. *Antiparasitic Agents. *Antiparasitic Products, Insecticides and Repellents. *Antiplatyhelmintic Agents ... P01AX - Other agents against amoebiasis and other protozoal diseases. *P01A - AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL ...
Antiplatyhelmintic Agents Type of study: Prevalence study Country/Region as subject: Asia Language: English Journal: Southeast ... Antiplatyhelmintic Agents Type of study: Prevalence study Country/Region as subject: Asia Language: English Journal: Southeast ... Animals , Antiplatyhelmintic Agents/therapeutic use , Humans , Intestinal Diseases, Parasitic/drug therapy , Opisthorchiasis/ ...
Info Anti-Infective Agents, Local. * Info Antiparasitic Agents. * Info Antiplatyhelmintic Agents. Show more categories. Show ... Halogenated anti-infective agent that is used against trematode and cestode infestations. ...
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. ...
Antiplatyhelmintic Agents - administration & dosage , Antiplatyhelmintic Agents - therapeutic use , Stroke - prevention & ... Antiplatyhelmintic Agents - adverse effects , Stroke (Disease) , Care and treatment , Anticoagulants (Medicine) , Patient ...
Abdominal Pain/etiology ; Animals ; Antiplatyhelmintic Agents/therapeutic use ; Diagnosis, Differential ; Eosinophilia/etiology ...
Antineoplastic Agents. MeSH PA. D000977. Antiparasitic Agents. MeSH PA. D000980. Antiplatyhelmintic Agents. ... AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES. Other agents against amoebiasis and other protozoal diseases ...
  • Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. (readtiger.com)
  • Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS. (bvsalud.org)
  • An antischistosomal agent that has become obsolete. (nih.gov)
  • Ivermectin is a broad-spectrum antiparasitic agent. (meddic.jp)
  • Halogenated anti-infective agent that is used against trematode and cestode infestations. (nih.gov)
  • An antiplatyhelmintic agent is a type of anthelmintic designed to reduce flatworm infection. (wikipedia.org)
  • There are data to suggest that infection with these agents may activate the immune system in HIV-1 co-infected individuals and may lead to more rapid HIV disease progression. (clinicaltrials.gov)
  • The goal of this trial is to determine if treatment with the antiparasitic agent albendazole improves the outcome of neurocysticercosis infection. (clinicaltrials.gov)