beta 2-Glycoprotein I
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic
Pregnancy Complications, Hematologic
Skin Diseases, Vascular
Partial Thromboplastin Time
Enzyme-Linked Immunosorbent Assay
Blue Toe Syndrome
Lupus Vasculitis, Central Nervous System
Heart Valve Diseases
Blood Coagulation Factors
Antiphospholipid, anti-beta 2-glycoprotein-I and anti-oxidized-low-density-lipoprotein antibodies in antiphospholipid syndrome. (1/684)Antiphospholipid antibodies (aPL), anti-beta 2-glycoprotein I (anti-beta 2-GPI) and anti-oxidized-low-density lipoprotein (LDL) antibodies are all implicated in the pathogenesis of antiphospholipid syndrome. To investigate whether different autoantibodies or combinations thereof produced distinct effects related to their antigenic specificities, we examined the frequencies of antiphospholipid syndrome (APS)-related features in the presence of different antibodies [aPL, beta 2-GPI, anti-oxidized low density lipoprotein (LDL)] in 125 patients with APS. Median follow-up was 72 months: 58 patients were diagnosed as primary APS and 67 as APS plus systemic lupus erythematosus (SLE). Anticardiolipin antibodies (aCL), anti-beta 2-GPI and anti-oxidized LDL antibodies were determined by ELISA; lupus anticoagulant (LA) by standard coagulometric methods. Univariate analysis showed that patients positive for anti-beta 2-GPI had a higher risk of recurrent thrombotic events (OR = 3.64, 95% CI, p = 0.01) and pregnancy loss (OR = 2.99, 95% CI, p = 0.004). Patients positive for anti-oxidized LDL antibodies had a 2.24-fold increase in the risk of arterial thrombosis (2.24, 95% CI, p = 0.03) and lower risk of thrombocytopenia (OR = 0.41 95% CI, p = 0.04). Patients positive for aCL antibodies had a higher risk of pregnancy loss (OR = 4.62 95% CI, p = 0.001). When these data were tested by multivariate logistic regression, the association between anti-beta 2-GPI and pregnancy loss and the negative association between anti-oxidized LDL antibodies and thrombocytopenia disappeared. (+info)
Associations of anti-beta2-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groups. (2/684)OBJECTIVE: To determine any HLA associations with anti-beta2-glycoprotein I (anti-beta2GPI) antibodies in a large, retrospectively studied, multiethnic group of 262 patients with primary antiphospholipid antibody syndrome (APS), systemic lupus erythematosus (SLE), or another connective tissue disease. METHODS: Anti-beta2GPI antibodies were detected in sera using an enzyme-linked immunosorbent assay. HLA class II alleles (DRB1, DQA1, and DQB1) were determined by DNA oligotyping. RESULTS: The HLA-DQB1*0302 (DQ8) allele, typically carried on HLA-DR4 haplotypes, was associated with anti-beta2GPI when compared with both anti-beta2GPI-negative SLE patients and ethnically matched normal controls, especially in Mexican Americans and, to a lesser extent, in whites. Similarly, when ethnic groups were combined, HLA-DQB1*0302, as well as HLA-DQB1*03 alleles overall (DQB1*0301, *0302, and *0303), were strongly correlated with anti-beta2GPI antibodies. The HLA-DR6 (DR13) haplotype DRB1*1302; DQB1*0604/5 was also significantly increased, primarily in blacks. HLA-DR7 was not significantly increased in any of these 3 ethnic groups, and HLA-DR53 (DRB4*0101) was increased in Mexican Americans only. CONCLUSION: Certain HLA class II haplotypes genetically influence the expression of antibodies to beta2GPI, an important autoimmune response in the APS, but there are variations in HLA associations among different ethnic groups. (+info)
Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. (3/684)OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. METHODS: Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with > or =2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. RESULTS: Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. CONCLUSION: Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including beta2-glycoprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas. (+info)
The intrarenal vascular lesions associated with primary antiphospholipid syndrome. (4/684)Even 10 yr after the identification of the antiphospholipid syndrome (APS), renal involvement in the course of APS is still relatively unrecognized, and is probably underestimated. The association of anticardiolipin antibodies and/or lupus anticoagulant with the development of a vaso-occlusive process involving numerous organs is now confirmed. In a multicenter study, 16 cases of "primary" APS (PAPS) were found and followed for 5 yr or more, all with renal biopsy. In all 16 cases of PAPS, there was a vascular nephropathy characterized by small vessel vaso-occlusive lesions associated with fibrous intimal hyperplasia of interlobular arteries (12 patients), recanalizing thrombi in arteries and arterioles (six patients), and focal cortical atrophy (10 patients). In combination, these led to progressive destruction of the kidney, accelerated by acute glomerular and arteriolar microangiopathy in five patients. Focal cortical atrophy is a distinctive lesion, present in 10 biopsies, and likely represents the histologic and functional renal analogue to the multiple cerebral infarcts detected on imaging studies. The clinical hallmark of this vascular nephropathy in PAPS is systemic hypertension, only variably associated with renal insufficiency, proteinuria, or hematuria. The ensemble of histologic renal lesions defined in this study should aid in the separation of the lesions found in cases of secondary APS, especially systemic lupus erythematosus, into those lesions related to APS and those related to the underlying disease. (+info)
Mycoplasma penetrans bacteremia and primary antiphospholipid syndrome. (5/684)Mycoplasma penetrans, a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology and pathogenesis are unknown). (+info)
Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion. (6/684)We describe the case of a 39-year-old woman who suffered two iliofemoral venous thromboses, a cerebral ischemic infarct and recurrent fetal loss. Initial studies showed high levels of antiphospholipid antibodies (APAs) and a moderate thrombocytopenia. After her second miscarriage, laboratory diagnosis revealed that the woman was heterozygous for the factor V Leiden mutation and had a functional protein S deficiency as well as anti-protein S and anti-beta 2-glycoprotein I antibodies. The impairment of the protein C pathway at various points could well explain the recurrent thromboses in the patient and supports the role of a disturbed protein C system in the pathophysiology of thrombosis in patients with APAs. (+info)
Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome. (7/684)The present study was designed to investigate the effects of immunoglobulin G obtained from patients with antiphospholipid syndrome (APS) on in-vitro models of trophoblast invasiveness and differentiation. We tested the binding of affinity-purified immunoglobulin G to human primary trophoblast cells. These antibodies affected the invasiveness and differentiation of cytotrophoblast cells after binding to the cell surface. In addition, we determined whether the drugs used to treat APS might be able to restore the trophoblast functions. Low-molecular weight heparin, in a dose-dependent manner, significantly reduced the immunoglobulin G binding to trophoblast cells and restored in-vitro placental invasiveness and differentiation. No effect was observed in the presence of acetylsalicylic acid. These observations may help in understanding the role of these treatments in women with APS. (+info)
Flank ulcer in a patient with primary antiphospholipid syndrome. (8/684)A 32-year-old woman had a recurrent shallow ulcer on the flank. A biopsy specimen showed thromboses in the dermal vessels and she was found to have circulating antiphospholipid antibody with no associated systemic disease. A clean ulcer developed on the flank of a patient with primary antiphospholipid syndrome is considered to be a rarely encountered/unusual presentation of this syndrome. (+info)
The syndrome is typically diagnosed based on the presence of anticardiolipin antibodies (aCL) or lupus anticoagulant in the blood. Treatment for antiphospholipid syndrome may involve medications to prevent blood clots, such as heparin or warfarin, and aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation. In some cases, intravenous immunoglobulin (IVIG) may be given to reduce the levels of antibodies in the blood. Plasmapheresis, a process that removes antibodies from the blood, may also be used in some cases.
Antiphospholipid syndrome is associated with other autoimmune disorders, such as systemic lupus erythematosus (SLE), and may be triggered by certain medications or infections. It is important for individuals with antiphospholipid syndrome to work closely with their healthcare provider to manage their condition and reduce the risk of complications.
Examples: Some examples of catastrophic illnesses include:
1. Cancer: Especially aggressive forms such as pancreatic, lung, and brain cancer.
2. Neurodegenerative diseases: Conditions such as Alzheimer's disease, Parkinson's disease, and motor neuron disease that can lead to cognitive decline, memory loss, and difficulty with movement and communication.
3. Organ transplant: The need for an organ transplant, particularly if the patient has end-stage renal disease or liver failure, can be catastrophic due to the high cost of medical care and the risk of complications.
4. Severe burns: Burns that cover a large portion of the body can require prolonged hospitalization, multiple surgeries, and rehabilitation, resulting in significant financial and emotional burden on the patient and their family.
5. Traumatic brain injury: A severe head injury can lead to long-term cognitive impairment, memory loss, and difficulty with communication and mobility, which can be catastrophic for the affected individual and their family.
6. Rare genetic disorders: Conditions such as Huntington's disease, cystic fibrosis, and sickle cell anemia are rare and can have a significant impact on the patient's quality of life, requiring extensive medical care and financial resources.
Impact on patients and families: Catastrophic illnesses can have a profound impact on both the patient and their family members. The physical and emotional toll of these conditions can lead to significant stress, anxiety, and depression. Additionally, the financial burden of medical care can result in bankruptcy, loss of employment, and other social and economic challenges.
Insurance coverage: To address the financial burden of catastrophic illnesses, many insurance plans offer catastrophic coverage, which provides a high level of coverage for expensive medical services and procedures. However, these policies often have high deductibles and co-payments, making them unaffordable for some families.
Government assistance: Governments around the world provide various forms of assistance to individuals with catastrophic illnesses. For example, in the United States, Medicare and Medicaid offer coverage for certain medical services and prescription drugs, while Social Security Disability Insurance (SSDI) provides financial support for individuals who are unable to work due to a disabling condition.
Charitable organizations: Many charitable organizations provide financial assistance and other resources to individuals with catastrophic illnesses and their families. For example, the Ronald McDonald House Charities provides housing and other support services to families of children receiving medical treatment for serious illnesses.
Research and development: Research into new treatments and therapies is ongoing for many catastrophic illnesses. Stem cell research, gene therapy, and other innovative approaches hold promise for improving outcomes and quality of life for individuals with these conditions.
Conclusion: Catastrophic illnesses are a significant challenge to the healthcare systems around the world. These illnesses can have a profound impact on the lives of patients and their families, both in terms of medical costs and quality of life. However, there are many resources available to help manage the financial burden of these conditions, including government assistance programs, charitable organizations, and research into new treatments and therapies. By leveraging these resources and working together to address the challenges posed by catastrophic illnesses, we can improve outcomes and quality of life for those affected by these conditions.
There are several types of thrombosis, including:
1. Deep vein thrombosis (DVT): A clot forms in the deep veins of the legs, which can cause swelling, pain, and skin discoloration.
2. Pulmonary embolism (PE): A clot breaks loose from another location in the body and travels to the lungs, where it can cause shortness of breath, chest pain, and coughing up blood.
3. Cerebral thrombosis: A clot forms in the brain, which can cause stroke or mini-stroke symptoms such as weakness, numbness, or difficulty speaking.
4. Coronary thrombosis: A clot forms in the coronary arteries, which supply blood to the heart muscle, leading to a heart attack.
5. Renal thrombosis: A clot forms in the kidneys, which can cause kidney damage or failure.
The symptoms of thrombosis can vary depending on the location and size of the clot. Some common symptoms include:
1. Swelling or redness in the affected limb
2. Pain or tenderness in the affected area
3. Warmth or discoloration of the skin
4. Shortness of breath or chest pain if the clot has traveled to the lungs
5. Weakness, numbness, or difficulty speaking if the clot has formed in the brain
6. Rapid heart rate or irregular heartbeat
7. Feeling of anxiety or panic
Treatment for thrombosis usually involves medications to dissolve the clot and prevent new ones from forming. In some cases, surgery may be necessary to remove the clot or repair the damaged blood vessel. Prevention measures include maintaining a healthy weight, exercising regularly, avoiding long periods of immobility, and managing chronic conditions such as high blood pressure and diabetes.
The term "systemic" refers to the fact that the disease affects multiple organ systems, including the skin, joints, kidneys, lungs, and nervous system. LES is a complex condition, and its symptoms can vary widely depending on which organs are affected. Common symptoms include fatigue, fever, joint pain, rashes, and swelling in the extremities.
There are several subtypes of LES, including:
1. Systemic lupus erythematosus (SLE): This is the most common form of the disease, and it can affect anyone, regardless of age or gender.
2. Discoid lupus erythematosus (DLE): This subtype typically affects the skin, causing a red, scaly rash that does not go away.
3. Drug-induced lupus erythematosus: This form of the disease is caused by certain medications, and it usually resolves once the medication is stopped.
4. Neonatal lupus erythematosus: This rare condition affects newborn babies of mothers with SLE, and it can cause liver and heart problems.
There is no cure for LES, but treatment options are available to manage the symptoms and prevent flares. Treatment may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive medications, and antimalarial drugs. In severe cases, hospitalization may be necessary to monitor and treat the disease.
It is important for people with LES to work closely with their healthcare providers to manage their condition and prevent complications. With proper treatment and self-care, many people with LES can lead active and fulfilling lives.
Examples of syndromes include:
1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21 that affects intellectual and physical development.
2. Turner syndrome: A genetic disorder caused by a missing or partially deleted X chromosome that affects physical growth and development in females.
3. Marfan syndrome: A genetic disorder affecting the body's connective tissue, causing tall stature, long limbs, and cardiovascular problems.
4. Alzheimer's disease: A neurodegenerative disorder characterized by memory loss, confusion, and changes in personality and behavior.
5. Parkinson's disease: A neurological disorder characterized by tremors, rigidity, and difficulty with movement.
6. Klinefelter syndrome: A genetic disorder caused by an extra X chromosome in males, leading to infertility and other physical characteristics.
7. Williams syndrome: A rare genetic disorder caused by a deletion of genetic material on chromosome 7, characterized by cardiovascular problems, developmental delays, and a distinctive facial appearance.
8. Fragile X syndrome: The most common form of inherited intellectual disability, caused by an expansion of a specific gene on the X chromosome.
9. Prader-Willi syndrome: A genetic disorder caused by a defect in the hypothalamus, leading to problems with appetite regulation and obesity.
10. Sjogren's syndrome: An autoimmune disorder that affects the glands that produce tears and saliva, causing dry eyes and mouth.
Syndromes can be diagnosed through a combination of physical examination, medical history, laboratory tests, and imaging studies. Treatment for a syndrome depends on the underlying cause and the specific symptoms and signs presented by the patient.
A condition in which spontaneous abortions occur repeatedly, often due to an underlying cause such as a uterine anomaly or infection. Also called recurrent spontaneous abortion.
Synonym(s): habitual abortion, recurrent abortion, spontaneous abortion.
Antonym(s): multiple pregnancy, retained placenta.
Example Sentence: "The patient had experienced four habitual abortions in the past year and was concerned about her ability to carry a pregnancy to term."
The primary symptom of Sneddon syndrome is excessive intracranial pressure (ICP), which can lead to enlargement of the skull and deformation of the brain. Other symptoms may include headaches, seizures, and developmental delays. The condition usually becomes apparent in infancy or early childhood, and its course can be highly variable.
Ophthalmological manifestations are a key feature of Sneddon syndrome, with most affected individuals developing characteristic eye abnormalities such as papilledema (swelling of the optic disc), retinal detachment, and cataracts. These changes can lead to vision loss if left untreated.
Sneddon syndrome is a rare disorder, with fewer than 200 cases reported in the medical literature. It is important to note that there is no cure for Sneddon syndrome, but various treatments such as medications to reduce ICP and surgical interventions can help manage the symptoms and prevent complications. Early diagnosis and intervention are crucial to improve outcomes for affected individuals.
1. Iron deficiency anemia: This is the most common hematologic complication of pregnancy, caused by the increased demand for iron and the potential for poor dietary intake or gastrointestinal blood loss.
2. Thrombocytopenia: A decrease in platelet count, which can be mild and resolve spontaneously or severe and require treatment.
3. Leukemia: Rare but potentially serious, leukemia can occur during pregnancy and may require prompt intervention to ensure the health of both the mother and the fetus.
4. Thrombosis: The formation of a blood clot in a blood vessel, which can be life-threatening for both the mother and the baby if left untreated.
5. Hemorrhage: Excessive bleeding during pregnancy, which can be caused by various factors such as placenta previa or abruption.
6. Preeclampsia: A condition characterized by high blood pressure and damage to organs such as the kidneys and liver, which can increase the risk of hemorrhage and other complications.
7. Ectopic pregnancy: A pregnancy that develops outside of the uterus, often in the fallopian tube, which can cause severe bleeding and be life-threatening if left untreated.
There are several types of thrombophilia, including:
1. Factor V Leiden: This is the most common inherited thrombophilia and is caused by a mutation in the Factor V gene.
2. Prothrombin G20210A: This is another inherited thrombophilia that is caused by a mutation in the Prothrombin gene.
3. Protein C and S deficiency: These are acquired deficiencies of protein C and S, which are important proteins that help to prevent blood clots.
4. Antiphospholipid syndrome: This is an autoimmune disorder that causes the body to produce antibodies against phospholipids, which can lead to blood clots.
5. Cancer-associated thrombophilia: This is a condition where cancer patients are at a higher risk of developing blood clots due to their cancer and its treatment.
6. Hormone-related thrombophilia: This is a condition where hormonal changes, such as those that occur during pregnancy or with the use of hormone replacement therapy, increase the risk of blood clots.
7. Inherited platelet disorders: These are rare conditions that affect the way platelets function and can increase the risk of blood clots.
8. Anti-cardiolipin antibodies: These are autoantibodies that can cause blood clots.
9. Lupus anticoagulant: This is an autoantibody that can cause blood clots.
10. Combined genetic and acquired risk factors: Some people may have a combination of inherited and acquired risk factors for thrombophilia.
Thrombophilia can be diagnosed through various tests, including:
1. Blood tests: These tests measure the levels of certain proteins in the blood that are associated with an increased risk of blood clots.
2. Genetic testing: This can help identify inherited risk factors for thrombophilia.
3. Imaging tests: These tests, such as ultrasound and venography, can help doctors visualize the blood vessels and look for signs of blood clots.
4. Thrombin generation assay: This test measures the body's ability to produce thrombin, a protein that helps form blood clots.
5. Platelet function tests: These tests assess how well platelets work and whether they are contributing to the development of blood clots.
Treatment for thrombophilia usually involves medications to prevent or dissolve blood clots, as well as measures to reduce the risk of developing new clots. These may include:
1. Anticoagulant drugs: These medications, such as warfarin and heparin, are used to prevent blood clots from forming.
2. Thrombolytic drugs: These medications are used to dissolve blood clots that have already formed.
3. Compression stockings: These stockings can help reduce swelling and improve blood flow in the affected limb.
4. Elevating the affected limb: This can help reduce swelling and improve blood flow.
5. Avoiding long periods of immobility: This can help reduce the risk of developing blood clots.
In some cases, surgery may be necessary to remove a blood clot or repair a damaged blood vessel. In addition, people with thrombophilia may need to make lifestyle changes, such as avoiding long periods of immobility and taking regular breaks to move around, to reduce their risk of developing blood clots.
Overall, the prognosis for thrombophilia is generally good if the condition is properly diagnosed and treated. However, if left untreated, thrombophilia can lead to serious complications, such as pulmonary embolism or stroke, which can be life-threatening. It is important for people with thrombophilia to work closely with their healthcare provider to manage the condition and reduce the risk of complications.
1. Preeclampsia: A condition characterized by high blood pressure during pregnancy, which can lead to complications such as stroke or premature birth.
2. Gestational diabetes: A type of diabetes that develops during pregnancy, which can cause complications for both the mother and the baby if left untreated.
3. Placenta previa: A condition in which the placenta is located low in the uterus, covering the cervix, which can cause bleeding and other complications.
4. Premature labor: Labor that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
5. Fetal distress: A condition in which the fetus is not getting enough oxygen, which can lead to serious health problems or even death.
6. Postpartum hemorrhage: Excessive bleeding after delivery, which can be life-threatening if left untreated.
7. Cesarean section (C-section) complications: Complications that may arise during a C-section, such as infection or bleeding.
8. Maternal infections: Infections that the mother may contract during pregnancy or childbirth, such as group B strep or urinary tract infections.
9. Preterm birth: Birth that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
10. Chromosomal abnormalities: Genetic disorders that may affect the baby's growth and development, such as Down syndrome or Turner syndrome.
It is important for pregnant women to receive regular prenatal care to monitor for any potential complications and ensure a healthy pregnancy outcome. In some cases, pregnancy complications may require medical interventions, such as hospitalization or surgery, to ensure the safety of both the mother and the baby.
Symptoms of venous thrombosis may include pain, swelling, warmth, and redness in the affected limb. In some cases, the clot can break loose and travel to the lungs, causing a potentially life-threatening condition called Pulmonary Embolism (PE).
Treatment for venous thrombosis typically involves anticoagulant medications to prevent the clot from growing and to prevent new clots from forming. In some cases, a filter may be placed in the vena cava, the large vein that carries blood from the lower body to the heart, to prevent clots from traveling to the lungs.
Prevention of venous thrombosis includes encouraging movement and exercise, avoiding long periods of immobility, and wearing compression stockings or sleeves to compress the veins and improve blood flow.
1. Erythema nodosum: This is a condition that causes red, painful lumps to form on the skin, often on the legs. It is usually caused by an allergic reaction or a bacterial infection.
2. Pyoderma gangrenosum: This is a condition that causes large, painful sores to form on the skin, often after surgery or injury. The sores can become infected and leave scars.
3. Vasculitis: This is a general term for inflammation of the blood vessels. It can cause a range of symptoms, including skin rashes, joint pain, and fatigue.
4. Cutaneous leukocytoclastic angiitis (CLA): This is a rare condition that causes small blood vessels in the skin to become inflamed and damaged. It can lead to skin rashes, ulcers, and scarring.
5. Polyarteritis nodosa: This is a rare condition that affects the small and medium-sized arteries in the body, including those in the skin. It can cause skin rashes, joint pain, and other symptoms.
6. Takayasu arteritis: This is a rare condition that affects the aorta and its branches, causing inflammation and damage to the blood vessels. It can lead to skin rashes, joint pain, and other symptoms.
7. Buerger's disease: This is a rare condition that affects the small and medium-sized blood vessels in the hands and feet, causing inflammation and damage. It can lead to skin rashes, ulcers, and gangrene.
8. Scleroderma: This is a chronic autoimmune disease that affects the skin and other organs. It can cause thickening and hardening of the skin, as well as joint pain, fatigue, and other symptoms.
9. Systemic lupus erythematosus (SLE): This is a chronic autoimmune disease that can affect many parts of the body, including the skin. It can cause skin rashes, joint pain, fatigue, and other symptoms.
10. Rheumatoid arthritis: This is a chronic autoimmune disease that affects the joints and can also cause inflammation in other parts of the body, including the skin. It can lead to skin rashes, joint pain, and other symptoms.
These are just a few examples of conditions that can cause skin rashes and joint pain. There are many other possible causes, and it's important to see a healthcare professional for an accurate diagnosis and appropriate treatment.
The symptoms of pulmonary embolism can vary, but may include shortness of breath, chest pain, coughing up blood, rapid heart rate, and fever. In some cases, the clot may be large enough to cause a pulmonary infarction (a " lung injury" caused by lack of oxygen), which can lead to respiratory failure and death.
Pulmonary embolism can be diagnosed with imaging tests such as chest X-rays, CT scans, and ultrasound. Treatment typically involves medications to dissolve the clot or prevent new ones from forming, and in some cases, surgery may be necessary to remove the clot.
Preventive measures include:
* Avoiding prolonged periods of immobility, such as during long-distance travel
* Exercising regularly to improve circulation
* Managing chronic conditions such as high blood pressure and cancer
* Taking blood-thinning medications to prevent clot formation
Early recognition and treatment of pulmonary embolism are critical to reduce the risk of complications and death.
Hellp Syndrome is a medical emergency that requires immediate attention. Treatment typically involves providing supportive care, such as oxygen therapy, mechanical ventilation, and fluid and electrolyte replacement, as well as addressing the underlying cause of the syndrome, such as preeclampsia or eclampsia. In severe cases, delivery of the baby may be necessary to prevent further complications.
There are different types of fetal death, including:
1. Stillbirth: This refers to the death of a fetus after the 20th week of gestation. It can be caused by various factors, such as infections, placental problems, or umbilical cord compression.
2. Miscarriage: This occurs before the 20th week of gestation and is usually due to chromosomal abnormalities or hormonal imbalances.
3. Ectopic pregnancy: This is a rare condition where the fertilized egg implants outside the uterus, usually in the fallopian tube. It can cause fetal death and is often diagnosed in the early stages of pregnancy.
4. Intrafamilial stillbirth: This refers to the death of two or more fetuses in a multiple pregnancy, usually due to genetic abnormalities or placental problems.
The diagnosis of fetal death is typically made through ultrasound examination or other imaging tests, such as MRI or CT scans. In some cases, the cause of fetal death may be unknown, and further testing and investigation may be required to determine the underlying cause.
There are various ways to manage fetal death, depending on the stage of pregnancy and the cause of the death. In some cases, a vaginal delivery may be necessary, while in others, a cesarean section may be performed. In cases where the fetus has died due to a genetic abnormality, couples may choose to undergo genetic counseling and testing to assess their risk of having another affected pregnancy.
Overall, fetal death is a tragic event that can have significant emotional and psychological impact on parents and families. It is essential to provide compassionate support and care to those affected by this loss, while also ensuring appropriate medical management and follow-up.
There are several possible causes of thrombocytopenia, including:
1. Immune-mediated disorders such as idiopathic thrombocytopenic purpura (ITP) or systemic lupus erythematosus (SLE).
2. Bone marrow disorders such as aplastic anemia or leukemia.
3. Viral infections such as HIV or hepatitis C.
4. Medications such as chemotherapy or non-steroidal anti-inflammatory drugs (NSAIDs).
5. Vitamin deficiencies, especially vitamin B12 and folate.
6. Genetic disorders such as Bernard-Soulier syndrome.
7. Sepsis or other severe infections.
8. Disseminated intravascular coagulation (DIC), a condition where blood clots form throughout the body.
9. Postpartum thrombocytopenia, which can occur in some women after childbirth.
Symptoms of thrombocytopenia may include easy bruising, petechiae (small red or purple spots on the skin), and prolonged bleeding from injuries or surgical sites. Treatment options depend on the underlying cause but may include platelet transfusions, steroids, immunosuppressive drugs, and in severe cases, surgery.
In summary, thrombocytopenia is a condition characterized by low platelet counts that can increase the risk of bleeding and bruising. It can be caused by various factors, and treatment options vary depending on the underlying cause.
Symptoms of meningism may include fever, headache, stiff neck, confusion, and sensitivity to light. In severe cases, the condition can lead to seizures, coma, and even death.
Diagnosis of meningism typically involves a physical examination, medical history, and diagnostic tests such as lumbar puncture or imaging studies. Treatment depends on the underlying cause of the condition and may involve antibiotics, antiviral medication, corticosteroids, or surgery.
In some cases, meningism can be a symptom of a more serious underlying condition, such as meningitis or encephalitis, which can be life-threatening. Therefore, it is important to seek medical attention immediately if symptoms persist or worsen over time.
The primary symptoms of Blue Toe Syndrome are:
* Discoloration: The affected areas turn white or blue due to lack of blood flow.
* Numbness and tingling: There is a loss of sensation in the fingers or toes.
* Pain: The affected areas may feel painful or tender to the touch.
* Coldness: The extremities may feel cold to the touch.
The exact cause of Blue Toe Syndrome is not known, but it is believed to be related to an autoimmune disorder or a response to certain triggers such as cold temperatures, stress, or certain medications. The condition can also be associated with other medical conditions, such as scleroderma, lupus, or rheumatoid arthritis.
There is no cure for Blue Toe Syndrome, but various treatments can help manage the symptoms. These may include:
* Medications: Drugs such as calcium channel blockers, alpha-blockers, and vasodilators can be used to widen blood vessels and improve blood flow.
* Lifestyle changes: Avoiding triggers such as cold temperatures, quitting smoking, and exercising regularly can help manage the condition.
* Physical therapy: Gentle exercises can help improve blood flow and reduce pain.
* Surgery: In severe cases, surgery may be necessary to improve blood flow or repair damaged tissues.
In conclusion, Blue Toe Syndrome is a condition that affects blood flow to the fingers and toes, causing discoloration, numbness, pain, and coldness. While there is no cure for the condition, various treatments can help manage the symptoms and improve quality of life.
Primary adrenal insufficiency, also known as Addison's disease, is a rare condition where the adrenal glands are damaged or destroyed, leading to a decrease in cortisol and aldosterone production. This can be caused by autoimmune disorders, genetic defects, or viral infections.
Secondary adrenal insufficiency is more common and occurs when the pituitary gland, located at the base of the brain, does not produce enough adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol and aldosterone. This can be caused by a variety of factors, including hypothyroidism, hyperthyroidism, and pituitary tumors.
Adrenal insufficiency can cause a range of symptoms, including fatigue, weight loss, muscle weakness, and low blood pressure. Treatment typically involves hormone replacement therapy with cortisol and aldosterone supplements, as well as addressing any underlying causes of the condition.
In summary, adrenal insufficiency is a condition where the adrenal glands do not produce enough cortisol and aldosterone hormones, leading to a range of symptoms and potential complications. It can be classified into primary and secondary types, and treatment involves hormone replacement therapy and addressing any underlying causes.
Symptoms of CNS lupus vasculitis can include headaches, seizures, confusion, weakness or paralysis, vision problems, and changes in personality or behavior. The condition can be difficult to diagnose, as it may mimic other conditions such as stroke, infection, or tumors.
Treatment of CNS lupus vasculitis typically involves high doses of corticosteroids to reduce inflammation and prevent further damage. In severe cases, intravenous immunoglobulin (IVIG) or plasmapheresis may be used to remove harmful antibodies from the blood. Anticoagulation therapy may also be prescribed to prevent blood clots.
While CNS lupus vasculitis can be a life-threatening condition, early diagnosis and aggressive treatment can improve outcomes. However, long-term follow-up is essential to monitor for recurrences of the disease and manage any ongoing neurological symptoms.
There are two main types of thrombophlebitis:
1. Superficial thrombophlebitis: This type of thrombophlebitis affects the superficial veins, which are located just under the skin. It is often caused by injury or trauma to the vein, and it can cause redness, swelling, and pain in the affected area.
2. Deep vein thrombophlebitis: This type of thrombophlebitis affects the deep veins, which are located deeper in the body. It is often caused by blood clots that form in the legs or arms, and it can cause symptoms such as pain, swelling, and warmth in the affected limb.
Thrombophlebitis can be caused by a variety of factors, including:
1. Injury or trauma to the vein
2. Blood clotting disorders
3. Prolonged bed rest or immobility
4. Surgery or medical procedures
5. Certain medications, such as hormone replacement therapy or chemotherapy
6. Age, as the risk of developing thrombophlebitis increases with age
7. Family history of blood clotting disorders
8. Increased pressure on the veins, such as during pregnancy or obesity
Thrombophlebitis can be diagnosed through a variety of tests, including:
1. Ultrasound: This test uses sound waves to create images of the veins and can help identify blood clots or inflammation.
2. Venography: This test involves injecting a dye into the vein to make it visible under X-ray imaging.
3. Blood tests: These can be used to check for signs of blood clotting disorders or other underlying conditions that may be contributing to the development of thrombophlebitis.
Treatment for thrombophlebitis typically involves anticoagulation therapy, which is designed to prevent the blood clot from growing larger and to prevent new clots from forming. This can involve medications such as heparin or warfarin, or other drugs that work by blocking the production of clots. In some cases, a filter may be placed in the vena cava, the large vein that carries blood from the lower body to the heart, to prevent clots from traveling to the lungs.
In addition to anticoagulation therapy, treatment for thrombophlebitis may also include:
1. Elevation of the affected limb to reduce swelling
2. Compression stockings to help reduce swelling and improve blood flow
3. Pain management with medication or heat or cold applications
4. Antibiotics if there is an infection
5. Rest and avoiding strenuous activities until the symptoms resolve.
In some cases, surgery may be necessary to remove the clot or repair the affected vein.
It's important to note that early diagnosis and treatment of thrombophlebitis can help prevent complications such as infection, inflammation, or damage to the valves in the affected vein. If you suspect you or someone else may have thrombophlebitis, it is important to seek medical attention promptly.
Examples of autoimmune diseases include:
1. Rheumatoid arthritis (RA): A condition where the immune system attacks the joints, leading to inflammation, pain, and joint damage.
2. Lupus: A condition where the immune system attacks various body parts, including the skin, joints, and organs.
3. Hashimoto's thyroiditis: A condition where the immune system attacks the thyroid gland, leading to hypothyroidism.
4. Multiple sclerosis (MS): A condition where the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to communication problems between the brain and the rest of the body.
5. Type 1 diabetes: A condition where the immune system attacks the insulin-producing cells in the pancreas, leading to high blood sugar levels.
6. Guillain-Barré syndrome: A condition where the immune system attacks the nerves, leading to muscle weakness and paralysis.
7. Psoriasis: A condition where the immune system attacks the skin, leading to red, scaly patches.
8. Crohn's disease and ulcerative colitis: Conditions where the immune system attacks the digestive tract, leading to inflammation and damage to the gut.
9. Sjögren's syndrome: A condition where the immune system attacks the glands that produce tears and saliva, leading to dry eyes and mouth.
10. Vasculitis: A condition where the immune system attacks the blood vessels, leading to inflammation and damage to the blood vessels.
The symptoms of autoimmune diseases vary depending on the specific disease and the organs or tissues affected. Common symptoms include fatigue, fever, joint pain, skin rashes, and swollen lymph nodes. Treatment for autoimmune diseases typically involves medication to suppress the immune system and reduce inflammation, as well as lifestyle changes such as dietary changes and stress management techniques.
There are several types of heart valve diseases, including:
1. Mitral regurgitation: This occurs when the mitral valve does not close properly, allowing blood to flow backward into the left atrium.
2. Aortic stenosis: This occurs when the aortic valve becomes narrowed or blocked, restricting blood flow from the left ventricle into the aorta.
3. Pulmonary stenosis: This occurs when the pulmonary valve becomes narrowed or blocked, restricting blood flow from the right ventricle into the pulmonary artery.
4. Tricuspid regurgitation: This occurs when the tricuspid valve does not close properly, allowing blood to flow backward into the right atrium.
5. Heart valve thickening or calcification: This can occur due to aging, rheumatic fever, or other conditions that cause inflammation in the heart.
6. Endocarditis: This is an infection of the inner lining of the heart, which can damage the heart valves.
7. Rheumatic heart disease: This is a condition caused by rheumatic fever, which can damage the heart valves and cause scarring.
8. Congenital heart defects: These are heart defects that are present at birth, and can affect the heart valves as well as other structures of the heart.
Symptoms of heart valve disease can include shortness of breath, fatigue, swelling in the legs or feet, and chest pain. Treatment options for heart valve disease depend on the specific condition and can range from medication to surgery or other procedures.
Symptoms of endocarditis may include fever, fatigue, joint pain, and swelling in the legs and feet. In some cases, the condition can lead to serious complications, such as heart valve damage, stroke, or death.
Treatment for endocarditis typically involves antibiotics to clear the infection. In severe cases, surgery may be necessary to repair or replace damaged heart tissue. Preventive measures include good dental hygiene, avoiding risky behaviors such as injecting drugs, and keeping wounds clean and covered.
Endocarditis is a serious condition that can have long-term consequences if left untreated. Early diagnosis and treatment are essential to prevent complications and ensure the best possible outcome for patients.
The term "infarction" is derived from the Latin words "in" meaning "into" and "farcire" meaning "to stuff", which refers to the idea that the tissue becomes "stuffed" with blood, leading to cell death and necrosis.
Infarction can be caused by a variety of factors, including atherosclerosis (the buildup of plaque in the blood vessels), embolism (a blood clot or other foreign material that blocks the flow of blood), and vasospasm (constriction of the blood vessels).
The symptoms of infarction vary depending on the location and severity of the blockage, but can include chest pain or discomfort, shortness of breath, numbness or weakness in the affected limbs, and confusion or difficulty speaking or understanding speech.
Diagnosis of infarction typically involves imaging tests such as electrocardiograms (ECGs), echocardiograms, or computerized tomography (CT) scans to confirm the presence of a blockage and assess the extent of the damage. Treatment options for infarction include medications to dissolve blood clots, surgery to restore blood flow, and other interventions to manage symptoms and prevent complications.
Prevention of infarction involves managing risk factors such as high blood pressure, high cholesterol, smoking, and obesity, as well as maintaining a healthy diet and exercise routine. Early detection and treatment of blockages can help reduce the risk of infarction and minimize the damage to affected tissues.
Some common puerperal disorders include:
1. Puerperal fever: This is a bacterial infection that can occur during the postpartum period, usually caused by Streptococcus or Staphylococcus bacteria. Symptoms include fever, chills, and abdominal pain.
2. Postpartum endometritis: This is an inflammation of the lining of the uterus that can occur after childbirth, often caused by bacterial infection. Symptoms include fever, abdominal pain, and vaginal discharge.
3. Postpartum bleeding: This is excessive bleeding that can occur during the postpartum period, often caused by tears or lacerations to the uterus or cervix during childbirth.
4. Breast engorgement: This is a common condition that occurs when the breasts become full and painful due to milk production.
5. Mastitis: This is an inflammation of the breast tissue that can occur during breastfeeding, often caused by bacterial infection. Symptoms include redness, swelling, and warmth in the breast.
6. Postpartum depression: This is a mood disorder that can occur after childbirth, characterized by feelings of sadness, anxiety, and hopelessness.
7. Postpartum anxiety: This is an anxiety disorder that can occur after childbirth, characterized by excessive worry, fear, and anxiety.
8. Urinary incontinence: This is the loss of bladder control during the postpartum period, often caused by weakened pelvic muscles.
9. Constipation: This is a common condition that can occur after childbirth, often caused by hormonal changes and decreased bowel motility.
10. Breastfeeding difficulties: These can include difficulty latching, painful feeding, and low milk supply.
It's important to note that not all women will experience these complications, and some may have different symptoms or none at all. Additionally, some complications may require medical attention, while others may be managed with self-care measures or support from a healthcare provider. It's important for new mothers to seek medical advice if they have any concerns about their physical or emotional well-being during the postpartum period.
Antiphospholipid syndrome, familial
Catastrophic antiphospholipid syndrome
Low-density lipoprotein receptor-related protein 8
Stuart W. Jamieson
Dilute Russell's viper venom time
Nonsteroidal anti-inflammatory drug
Deep vein thrombosis
Massive perivillous fibrin deposition
Renal cortical necrosis
Michael D. Lockshin
CKLF-like MARVEL transmembrane domain-containing 5
List of MeSH codes (D12.776)
Venereal Disease Research Laboratory test
Renal vein thrombosis
List of syndromes
List of complications of pregnancy
Antiphospholipid Syndrome | National Institute of Neurological Disorders and Stroke
Antiphospholipid syndrome: MedlinePlus Genetics
Immunoassays for the Evaluation of Antiphospholipid Syndrome (APS) | AACC.org
Antiphospholipid Syndrome and Acute HIV Infection - Volume 16, Number 2-February 2010 - Emerging Infectious Diseases journal -...
Monocyte type I interferon signature in antiphospholipid syndrome is related to proinflammatory monocyte subsets,...
Health Topics | NHLBI, NIH
The Pathophysiology of Antiphospholipid Syndrome
Neurological manifestations in patients with antiphospholipid syndrome.
What tests are performed for Antiphospholipid syndrome?
Anti-Phospholipid-Syndrome - Laboratory Diagnostics & Cell Science Kuhlmann
New Registry Will Benefit Patients with Antiphospholipid Syndrome (APS) | NIAMS Archives
Clinical Trials in the Spotlight | NIAMS
Pre-eclampsia as a manifestation of antiphospholipid syndrome: assessing the current status. | Lupus;23(12): 1229-31, 2014 Oct...
The Antiphospholipid Syndrome | Williams Hematology Hemostasis and Thrombosis | AccessCardiology | McGraw Hill Medical
Blood Clots | Hypercoagulability | MedlinePlus
A Young Lady with ANA negative SLE with Secondary Anti Phospholipid Syndrome | OJOR
Most Popular Articles : Current Opinion in Rheumatology
How often does antiphospholipid syndrome (APS) progress to systemic lupus erythematosus (SLE)? • The Blood Project
DailyMed - SAVAYSA- edoxaban tosylate tablet, film coated
Síndrome de Sneddon asociado a síndrome antifosfolipídico: descripciones clínicas y revisión de la literatura<...
Budd-Chiari Syndrome: Practice Essentials, Background, Pathophysiology
Author Page for R Pérez-Montes :: SSRN
Validation of a Test for Fetal Malformations - Full Text View - ClinicalTrials.gov
NIMH » Key Personnel
EULAR recommendations for cardiovascular risk management in Rheumatic and Musculoskeletal Diseases, including Systemic Lupus...
How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review | Blood | American...
- Antiphospholipid syndrome (APS) is a rare autoimmune disorder caused when antibodies-immune system cells that fight off bacteria and viruses-mistakenly attack normal proteins in the blood. (nih.gov)
- The antibodies that cause antiphospholipid syndrome are called lupus anticoagulant, anticardiolipin, and anti-B2 glycoprotein I. These antibodies are referred to as antiphospholipid antibodies. (medlineplus.gov)
- People with this condition can test positive for one, two, or all three antiphospholipid antibodies in their blood. (medlineplus.gov)
- Antibodies normally attach (bind) to specific foreign particles and germs, marking them for destruction, but the antibodies in antiphospholipid syndrome attack normal human proteins. (medlineplus.gov)
- The production of the antiphospholipid antibodies may coincide with exposure to foreign invaders, such as viruses and bacteria, that are similar to normal human proteins. (medlineplus.gov)
- Certain genetic variations (polymorphisms) in a few genes have been found in people with antiphospholipid syndrome and may predispose individuals to produce the specific antibodies known to contribute to the formation of thromboses. (medlineplus.gov)
- Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. (who.int)
- we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy. (who.int)
- Antiphospholipid antibodies guine of Farhat Hached Hospital. (who.int)
- Antinuclear antithrombin, protein C, protein S or pres- antibodies were investigated with standard- ence of antiphospholipid antibodies, are ized enzyme-linked immunosorbent assay common in patients with retinal vein occlu- sions and may contribute to the etiology of (ELISA). (who.int)
- Antiphospholipid antibody syndrome (commonly referred to as APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid (aPL) antibodies in association with thrombosis and/or specific pregnancy-related morbidities. (aacc.org)
- Antibodies against PLs have been commonly found in patients with autoimmune diseases such as systemic lupus erythematosus and primary antiphospholipid syndrome, in which clinical manifestations (mainly thrombotic events) have been directly attributed to antibodies against PLs. (cdc.gov)
- The NIH-supported study, published in Science Translational Medicine , uncovered at least one of these autoimmune antiphospholipid (aPL) antibodies in about half of blood samples taken from 172 patients hospitalized with COVID-19. (nih.gov)
- The researchers wondered whether those usually short-lived aPL antibodies in COVID-19 could trigger a condition similar to antiphospholipid syndrome. (nih.gov)
- Again, those findings closely mirror what happens in mouse studies testing the effects of antibodies from patients with the most severe forms of antiphospholipid syndrome. (nih.gov)
- approximately one-third of those with antibodies (10 to 15 percent of all lupus patients) have clinical signs of the syndrome. (nih.gov)
- Antiphospholipid antibodies have also been identified in people who do not have an autoimmune disorder like lupus and who may not have any symptoms. (nih.gov)
- The presence of antiphospholipid antibodies is considered a risk factor for pre-eclampsia . (bvsalud.org)
- The antiphospholipid (aPL) syndrome (APS) is an acquired thrombophilic disorder in which patients have vascular thrombosis and/or pregnancy complications attributable to placental insufficiency, accompanied by laboratory evidence for the presence of antiphospholipid antibodies in blood. (mhmedical.com)
- The syndrome is identified by persistent abnormalities of laboratory tests for antibodies against these phospholipid-protein cofactor complexes, detected by immunoassays and by coagulation assays (also known as "lupus anticoagulant assays") that, paradoxically, report the inhibition of phospholipid-dependent coagulation reactions. (mhmedical.com)
- Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti-β 2 glycoprotein-1-specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. (ashpublications.org)
- Over the past several years, studies have described the management of patients with key clinical manifestations of antiphospholipid antibodies, including patients with antiphospholipid antibody syndrome. (ashpublications.org)
- As a result, evidence-based treatment recommendations are possible for selected patients with, or at risk of, thrombosis in the setting of antiphospholipid antibodies. (ashpublications.org)
- This review will focus on the management of selected patients with, or at risk of, thromboembolism in the setting of known, or suspected, antiphospholipid antibodies (aPLs), including patients meeting consensus conference criteria for APS. (ashpublications.org)
- Antiphospholipid and anticardiolipin antibodies should be obtained to evaluate for antiphospholipid syndrome. (medscape.com)
- Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab) - autoimmune conditions characterized by complement-mediated injury - is associated with increased risk of preeclampsia and miscarriage. (positivehealth.com)
- Many people with antiphospholipid syndrome also have other autoimmune disorders such as systemic lupus erythematosus . (medlineplus.gov)
- Ten to 15 percent of people with systemic lupus erythematosus have antiphospholipid syndrome. (medlineplus.gov)
- How often does antiphospholipid syndrome (APS) progress to systemic lupus erythematosus (SLE)? (thebloodproject.com)
- In addition, women with antiphospholipid syndrome are at greater risk of having a thrombosis during pregnancy than at other times during their lives. (medlineplus.gov)
- A thrombosis or pregnancy complication is typically the first sign of antiphospholipid syndrome. (medlineplus.gov)
- Increased Risk of Thrombosis in Patients with Triple Positive Antiphospholipid Syndrome: SAVAYSA use not recommended. (nih.gov)
- Antiphospholipid syndrome (APS) is a prothrombotic disorder predisposing to thrombocytopenia, recurrent pregnancy morbidity, and thrombosis. (ashpublications.org)
- Neurological manifestations in patients with antiphospholipid syndrome. (ac.ir)
- Background: Anti-phospholipids syndrome (APS) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. (ac.ir)
- According to Stephen I. Katz, M.D., Ph.D., NIAMS director, "The availability of this information will permit better comparisons among clinical research projects and help rheumatologists, obstetricians and other physicians resolve problems associated with the many manifestations of the syndrome. (nih.gov)
- Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. (ox.ac.uk)
- OBJECTIVE: To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression. (ox.ac.uk)
- The 11 patients were diagnosed with antiphospholipid syndrome: 9 patients were treated successfully with laser photocoagulation and anticoag- ulant and anti-aggregant therapy. (who.int)
- Le syndrome des antiphospholipides a été diagnostiqué chez 11 patients : neuf patients ont été traités avec succès par photocoagulation au laser associant un traitement anticoagulant et antiagrégant. (who.int)
- Patients with acute HIV infection frequently experience a syndrome characterized by fever, sore throat, lymphadenopathy, maculopapular rash, and lymphomonocytosis, which mimics acute infectious mononucleosis, 3-6 weeks after primary infection ( 1 ). (cdc.gov)
- That's remarkably similar to what had been seen previously in such studies of the autoantibodies from patients with established antiphospholipid syndrome. (nih.gov)
- Patients with antiphospholipid syndrome (APS) will benefit from a new national registry and tissue repository sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Center on Minority Health and Health Disparities (NCMHD). (nih.gov)
- APS may occur in patients with lupus and related autoimmune diseases or as a primary syndrome in otherwise healthy individuals. (nih.gov)
- Biomedical researchers at eight medical centers will collect and update clinical, demographic and laboratory information from patients with APS and make it available to researchers and to medical practitioners concerned with the diagnosis and treatment of this syndrome. (nih.gov)
- The prognosis is poor in patients with Budd-Chiari syndrome who remain untreated, with death resulting from progressive liver failure in 3 months to 3 years from the time of the diagnosis. (medscape.com)
- In infections involving the coronavirus that cause severe acute respiratory syndrome (SARS) , about one-third of recovered patients had lung impairment after three years, but those symptoms had largely cleared 15 years later. (latimes.com)
- coagulant was sought for in healthy individuals using use of both aPTT and KCT for the screening of patients in whom the antiphospholipid syndrome the aPTT and the KCT. (who.int)
- Overt Budd-Chiari syndrome generally requires the occlusion of at least 2 hepatic veins. (medscape.com)
- Abnormalities that have been reported in association with the syndrome include virtually all other autoimmune disorders, immune thrombocytopenia, acquired platelet function abnormalities, hypoprothrombinemia, acquired inhibitors of coagulation factors, livedo reticularis, heart valve abnormalities, atherosclerosis, pulmonary hypertension, and migraine. (mhmedical.com)
- These autoantibodies are a major focus in the Knight Lab's studies of an acquired autoimmune clotting condition called antiphospholipid syndrome . (nih.gov)
- In people with this syndrome, aPL autoantibodies attack phospholipids on the surface of cells including those that line blood vessels, leading to increased clotting. (nih.gov)
- Budd-Chiari syndrome is an uncommon condition induced by thrombotic or nonthrombotic obstruction of the hepatic venous outflow and is characterized by hepatomegaly, ascites, and abdominal pain. (medscape.com)
- Acute Respiratory Distress Syndrome (ARDS) is a serious lung condition that causes low blood oxygen levels. (nih.gov)
- In contrast, antiphospholipid syndrome complicated with pulmonary emboli is not commonly associated with acute retroviral syndrome. (cdc.gov)
- It is estimated that 20 percent of individuals younger than age 50 who have a stroke have antiphospholipid syndrome. (medlineplus.gov)
- Sneddon syndrome is a rare non-inflammatory obliterative vasculopathy, characterised by the association of cardiovascular (arterial hypertension, intermittent claudication, and coronary artery disease) and neurological events (ischaemic stroke, headache, dizziness and convulsions), and livedo reticularis/livedo racemosa. (edu.pe)
- At birth, infants of mothers with antiphospholipid syndrome may be small and underweight. (medlineplus.gov)
- Preeclampsia is a life threatening syndrome in mothers giving birth and a huge problem in South Africa, a summary of noted deficiencies there being applicable to other women. (positivehealth.com)
- APS is sometimes called "sticky blood syndrome" because of the increased tendency for blood clots to form. (nih.gov)
- In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body. (medlineplus.gov)
- Rarely, people with antiphospholipid syndrome develop thromboses in multiple blood vessels throughout their body. (medlineplus.gov)
- Antiphospholipid syndrome (APS) is an autoimmune condition that causes abnormal blood clots to form in the blood vessels. (nih.gov)
- APS takes a particular toll during pregnancy, when the syndrome may cause miscarriage, stillbirth, retarded growth of the fetus or pre-eclampsia (toxemia and high blood pressure). (nih.gov)
- A free flowing venous blood was collected oping countries and because of this, the diagnosis of from each subject, 4.5mls of which was delivered into plastic tubes containing 0.5ml of 3.2% triso- the antiphospholipid syndrome is often based on dium citrate. (who.int)
- Women with antiphospholipid syndrome are at increased risk of complications during pregnancy. (medlineplus.gov)
- Consider participating in a clinical trial so clinicians and scientists can learn more about antiphospholipid syndrome and related disorders. (nih.gov)
- This association has controls prior to their participation in our been termed the antiphospholipid syndrome study. (who.int)
- This study was conducted to determine whether drugs used for conventional treatments of pregnant women with antiphosholipid syndrome might be able to restore the gonadotrophin-releasing hormone (GnRH)-induced secretion of placental human chorionic gonadotrophin (HCG) in vitro. (nih.gov)
- What tests are performed for Antiphospholipid syndrome? (stago.com)
- Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera. (nih.gov)