Drugs used to treat or prevent parasitic infections.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Substances that are destructive to protozoans.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.
The acquired form of infection by Toxoplasma gondii in animals and man.
The deliberate and methodical practice of finding new applications for existing drugs.
The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.
Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.
A phylum of unicellular parasitic EUKARYOTES characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
Compounds that contain a BENZENE ring fused to a furan ring.
A plant genus in the family Boraginaceae, order Lamiales, subclass Asteridae. This is the True Heliotrope that should not be confused with an unrelated plant sometimes called Garden Heliotrope (VALERIAN).
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.
Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)
Pricing statements presented by more than one party for the purpose of securing a contract.
Hospital department responsible for the purchasing of supplies and equipment.
Inorganic compounds that contain chlorine as an integral part of the molecule.
Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.

Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (1/370)

OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.  (+info)

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (2/370)

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs.  (+info)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (3/370)

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.  (+info)

Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. (4/370)

In persons with onchocerciasis, topical application of the anthelminthic diethylcarbamazine (DEC) induces clinical and histologic responses similar to acute papular onchodermatitis, including recruitment of eosinophils to the skin. To determine whether the eosinophil chemokine eotaxin is likely to be associated with eosinophil recruitment in onchodermatitis, DEC was applied to a 5-cm2 area on the skin of infected persons, and biopsies were taken from lesions 24 h later. Histologic analysis showed elevated dermal and epidermal eosinophils compared with tissue from an adjacent (untreated) site. Reverse transcription-polymerase chain reaction showed that eotaxin gene expression in DEC-treated skin was elevated 2- to 17-fold compared with control tissue. Eotaxin immunoreactivity was noted in mononuclear cells and eosinophils in the perivascular region of the dermis and in lymphatic and vascular endothelial cells. Together, these observations are consistent with a role for eotaxin in recruitment of eosinophils to the dermis in early stage onchocercal skin disease.  (+info)

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. (5/370)

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decreased locomotion, and bang sensitivity. Binding assays using glc(1) head membranes showed a marked decrease in the affinity for nodulisporic acid and ivermectin. A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was introduced into a recombinant DmGluClalpha, and RNA encoding wild-type and mutant subunits was injected into Xenopus oocytes. Nodulisporic acid directly activated wild-type and mutant DmGluClalpha channels. However, mutant channels were approximately 10-fold less sensitive to activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providing direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.  (+info)

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons. (6/370)

The gamma-aminobutyric acid (GABA) receptor is an important site of action of a variety of chemicals, including barbiturates, benzodiazepines, picrotoxin, bicuculline, general anesthetics, alcohols, and certain insecticides. Fipronil is the first phenylpyrazole insecticide introduced for pest control. It is effective against some insects that have become resistant to the existing insecticides. To elucidate the mechanism of fipronil interaction with the mammalian GABA system, whole-cell patch-clamp experiments were performed using rat dorsal root ganglion neurons in primary culture. Fipronil suppressed the GABA-induced whole-cell currents reversibly in both closed and activated states. The IC(50) values and Hill coefficients for fipronil block of the GABA(A) receptor were estimated to be 1.66 +/- 0.18 microM and 1.23 +/- 0.14 for the closed receptor, respectively, and 1.61 +/- 0.14 microM and 0.96 +/- 0.06 for the activated receptor, respectively. The association rate and dissociation rate constants of fipronil effect were estimated to be 673 +/- 220 M(-1) s(-1) and 0.018 +/- 0.0035 s(-1) for the closed GABA(A) receptor, respectively, and 6600 +/- 380 M(-1) s(-1) and 0.11 +/- 0.0054 s(-1) for the activated GABA(A) receptor, respectively. Thus, both the association and dissociation rate constants of fipronil for the activated GABA(A) receptor are approximately 10 times as large as those for the closed receptor. Experiments with coapplication of fipronil and picrotoxinin indicated that they did not compete for the same binding site to block the receptor. It is concluded that although fipronil binds to the GABA(A) receptor without activation, channel opening facilitates fipronil binding to and unbinding from the receptor.  (+info)

GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. (7/370)

1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects. 2. Expression of glc-3 cRNA in XENOPUS oocytes resulted in the formation of homo-oligomeric L-glutamate-gated chloride channels with robust and rapidly desensitizing currents, an EC(50) of 1.9+/-0.03 mM and a Hill coefficient of 1.5+/-0.1. GABA, glycine, histamine and NMDA all failed to activate the GLC-3 homo-oligomer at concentrations of 1 mM. The anthelminthic, ivermectin, directly and irreversibly activated the L-glutamate-gated channel with an EC(50) of 0.4+/-0.02 microM. 3. The GLC-3 channels were selective for chloride ions, as shown by the shift in the reversal potential for L-glutamate-gated currents after the reduction of external Cl(-) from 107.6 to 62.5 mM. 4. Picrotoxinin failed to inhibit L-glutamate agonist responses at concentrations up to 1 mM. The polycyclic dinitrile, 3,3-bis-trifluoromethyl-bicyclo[2,2,1]heptane-2,2-dicarbonitrile (BIDN), completely blocked L-glutamate-induced chloride currents recorded from oocytes expressing GLC-3 with an IC(50) of 0.2+/-0.07 microM. The phenylpyrazole insecticide, fipronil, reversibly inhibited L-glutamate-gated currents recorded from the GLC-3 receptor with an IC(50) of 11.5+/-0.11 microM. 5. In this study, we detail the unusual antagonist pharmacology of a new GluCl subunit from C. elegans. Unlike all other native and recombinant nematode GluCl reported to date, the GLC-3 receptor is insensitive to picrotoxinin, but is sensitive to two other channel blockers, BIDN and fipronil. Further study of this receptor may provide insights into the molecular basis of non-competitive antagonism by these compounds.  (+info)

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. (8/370)

The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several techniques including DNA fragmentation assay and in situ and cytofluorometry terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling methods and YOPRO-1 staining allowed us to demonstrate that potassium antimonyl tartrate, an Sb(III)-containing drug, was able to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum at low concentrations (10 microg/ml). This observation was in close correlation with the toxicity of Sb(III) species against axenic amastigotes (50% inhibitory concentration of 4.75 microg/ml). Despite some similarities to apoptosis, nuclease activation was not a consequence of caspase-1, caspase-3, calpain, cysteine protease, or proteasome activation. Altogether, our results demonstrate that the antileishmanial toxicity of Sb(III) antimonials is associated with parasite oligonucleosomal DNA fragmentation, indicative of the occurrence of late events in the overall process of apoptosis. The elucidation of the biochemical pathways leading to cell death could allow the isolation of new therapeutic targets.  (+info)

TY - CHAP. T1 - Antiparasitic Agents. AU - Leder, Karin. AU - McGuinness, Sarah L. AU - Weller, Peter F. PY - 2019. Y1 - 2019. N2 - A number of effective antiprotozoal and anthelmintic drugs are currently available. Antiparasitic agents are important both for therapy of infected individual patients and for control of parasitic infections at the community level. Large-scale chemotherapy is reducing transmission, morbidity, and mortality of certain infections, including lymphatic filariasis, onchocerciasis, schistosomiasis, and infections with intestinal nematodes. However, the lack of financial incentives to develop new agents is a major limitation to the future of antiparasitic chemotherapy. Emerging resistance among parasites, lack of effective antiparasitic vaccines, and the enormous burden of disease worldwide also pose challenges to the effective management of parasitic infections. This chapter focuses on the mechanisms of action, pharmacology, clinical utility, and adverse effects of common ...
The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic Agents market report addresses f
The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R1 when taken individually is H or OH; R and R1 when taken together represent a double bond; R2 is an alpha-branched C3 -C8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C3 -C8 cycloalkyl, C5 -C8 cycloalkenyl or C5 -C8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C1 -C4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C1 -C4 alkyl groups or halo atoms; R3 is hydrogen or methyl; R4 is H or 4-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R2 is alkyl it is not isopropyl or sec-butyl; when R4 is H, each of R and R1 is H, and R2 is not methyl or ethyl; and when R4 is H, R is H, R1 is OH, and R2 is not 2-buten-2-yl, 2-penten-2-yl or 4-methyl-2-penten-2-yl. The compounds are broad spectrum antiparasitic agents having utility as
The U.S. small ruminant industry needs new antiparasitic drugs, and the sustainable use of these drugs will help maintain their effectiveness for as long as possible.
Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a terrible toll of human life, health and productivity, especially in tropical and subtropical regions, and are also highly significant in animal health worldwide. Antiparasitic drugs are the mainstays of control of most of these diseases, but in many cases current therapies are inadequate and in some the situation is deteriorating because of drug resistance. Microtubules, as essential components of almost all eukaryotic cells, are proven drug targets in many helminth diseases and show promise as targets for the development of new antiprotozoal drugs. Objective: This article reviews the chemistry of the microtubule inhibitors in current use and under investigation as antiparasitic agents, their activities against the major parasites and their mechanisms of action. New directions in both inhibitor chemistry and biological evaluation are discussed. Conclusions: The most promising immediate avenues for discovery and
Six medical students inhabiting a centuries-old, rat-infested house in Lübeck, in northern Germany, were suffering from itching papules and seropapules. Prior to these patients visit to our institute, their conditions had been diagnosed as pediculosis, scabies, or pulicosis and treated unsuccessfully with the antiparasitic agent lindane (0.3%). The final diagnosis, tropical rat mite dermatitis, was based on the identification of the arthropod Ornithonyssus bacoti, which has an unsegmented body with eight legs. No treatment was recommended, and the dermatitis disappeared within 2 weeks. Measures taken to prevent reinfestation included extermination of the rats and treatment of the rooms of the house with the acaricide benzyl benzoate. Because the mite O. bacoti spends a relatively short time on a host and penetrates the skin for feeding only, the application of an antiparasitic agent is not necessary. If indicated, treatment should be symptomatic.. ...
Abstract. To identify known drugs with previously unrecognized anticancer activity, we compiled and screened a library of such compounds to identify agents cyt
0069]Particularly preferred compounds according to formula (I) include: [0070]N-[1-cyano-1-(5-cyano-2,3-dihydro-1-benzofuran-2-yl)ethyl]-4-[(trif- luoromethyl)thio]benzamide, [0071]N-{(1R*)-1-cyano-1-[(2R*)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]eth- yl}-4-[(trifluoromethyl)thio]benzamide, [0072]N-{(1R)-1-cyano-1-[(2R)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0073]N-{(1S)-1-cyano-1-[(2S)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0074]N-{(1R*)-1-cyano-1-[(2S*)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]eth- yl}-4-[(trifluoromethyl)thio]benzamide, [0075]N-{(1R)-1-cyano-1-[(2S)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0076]N-{(1S)-1-cyano-1-[(2R)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0077]N-[1-cyano-1-(5-cyano-2,3-dihydro-1-benzofuran-2-yl)ethyl]-4-(trifl- uoromethoxy)benzamide, ...
Press Release issued Aug 2, 2017: The Animal Parasiticides Market is growing tremendously due to the increasing trend of pet adoption amongst people in developed as well as developing economies. However, the cost associated with animal parasiticides products, heavy expenditure on R & D for new product development and stringent regulatory policies related to the approval of animal parasiticides are factors that are adversely affecting the growth of the market.
Antiparasitic drugs are pharmaceuticals cure diseases caused by nematodes, cestodes, trematodes, protozoa, and amoeba. Antiparasitic drugs are highly effective, safe, cost effective drugs.
Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well. Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. Nitazoxanide is an effective first-line treatment for infection by Blastocystis ...
[110 Pages Report] Check for Discount on Global Animal Parasiticides Market Professional Survey Report 2017 report by QYResearch Group. This report studies Animal Parasiticides in Global market, especially in...
Parasitic infections afflict more than half of the worlds population and impose a substantial health burden, particularly in underdeveloped nations, where they are most prevalent. The reach of some parasitic diseases, including malaria, has expanded over the past few decades as a result of factors such as deforestation, population shifts, global warming, and other climatic events. Despite major efforts at vaccine development and vector control, chemotherapy remains the single most effective means of controlling parasitic infections. Efforts to combat the spread of some diseases are hindered by the development and spread of drug resistance, the limited introduction of new antiparasitic agents, and the proliferation of counterfeit medications. However, there are good reasons to be optimistic. Ambitious global initiatives aimed at controlling or eliminating threats such as AIDS, tuberculosis, and malaria have demonstrated some early successes. Recognition of the substantial burden imposed by the ...
Compare prices and find information about Antiparasitics prescription drugs. Antiparasitics are used to treat lice, parasitic infections, and...
Tly applied [1]. This antimicrobial was initially classified as an antiparasitic agent because of its activity against Taenia saginata and Hymenolepis nana. After that, a greater spectrum was discussed, provided the discovery of its antimicrobial activity against Enterobacteriaceae, MS049 chemical information Trichomonas vaginalis, Entamoeba histolytica, and Clostridium difficile. Nitazoxanide was regarded as a crucial therapeutic drug in metronidazole-resistant situations. Also to that, the spectrum of nitazoxanide also involves activity against viral illnesses for example hepatitis C. At present, nitazoxanide is definitely an critical option to treat Cryptosporidium and Giardia infections, which are crucial etiologies of diarrhea inside the pediatric population in developing countries, also as in immunocompromised individuals. Nitazoxanide can also be an alternative therapy for Clostridium difficile diarrhea in inpatients [2-6]. Also to the above uses, current studies have discovered a ...
Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the prevention and cure of parasitic infections.
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Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic burdens. The rise of drug-resistant parasites has created an urgent need to study their biology in hopes of uncovering new potential drug targets. It has been established that disrupting gene expression by interfering with lysine acetylation is detrimental to survival of apicomplexan (Toxoplasma gondii and Plasmodium spp.) and kinetoplastid (Leishmania spp. and Trypanosoma spp.) parasites. As readers of lysine acetylation, bromodomain proteins have emerged as key gene expression regulators and a promising new class of drug target. Here we review recent studies that demonstrate the essential roles played by bromodomain-containing proteins in parasite viability, invasion, and stage switching and present work showing the efficacy of bromodomain inhibitors as novel antiparasitic agents. In addition, we performed a phylogenetic analysis of ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Alcohol use disorders (AUDs) ranks third in the list of preventable causes of morbidity and mortality in United States having a major national impact affecting over 18 million people and causing over 100,000 deaths annually. The prevalence of AUDs, in combination with limited clinical efficacy of currently approved FDA drugs in the treatment of this disorder signifies the importance for development of novel therapeutic agents. Alcohol is known to modulate a multitude of receptors in the brain to induce its cellular and behavioral effects. Recent electrophysiological findings from our laboratory, coupled with genomic studies, have suggested that the ionotropic receptor, P2X4 receptor (P2X4R) is a critical target that is modulated by ethanol. P2X4R activity has been demonstrated to be inhibited by ethanol at intoxicating and anesthetic concentrations. Recent evidence from our laboratory using electrophysiological strategies has shown that the FDA approved antiparasitic agent, ivermectin (IVM) ...
Zimecterin® Paste kills important internal parasites, including bots and the arterial stages of S. Vulgaris, with a single dose. Zimecterin® Paste is potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. Zimecterin® Paste kills large strongyles, small stro
Raw, unfiltered organic apple cider vinegar (ACV) is full of vitamins, mineral and substances such as carotenoids, flavonoids, isoflavones and protease inhibitors.. These nutrients feed and modulate the immune system and improve skin health. For example, beta-carotene promotes skin regeneration while fiber improves digestive health to flush out toxins.. On the other hand, potassium balances pH balance of the skin to reduce inflammation and irritation.. Vinegar also works as an antibacterial, antifungal and antiparasitic agent to fight any infection causing the skin condition.. Heres how you can use this multipurpose food to heal your skin.. Click NEXT Button below to continue…. ...
The new orlistat battery was sold by the battery manufacturer. However, if a drug is manufactured in gabapentin no prescription a different way, then the drug is said to be manufactured by means of a biosimilar. While there are lots of fish medications out there, none are more effective than valtrex for fish and aquariums. Zulutrade.co.uk - do you want to save money on your medicines and healthcare? Ivermectin is an injectable drug with a long history of safe use and high efficacy as an antiparasitic agent. If you can not treat these conditions then discuss with your physician if you are a candidate for a hormone therapy. Bayer brand name levitra side effects side action. We have a very old house, with 2 big dogs and a 3 year old daughter. Antibiotics are classified into two groups: the para que sirve el gabapentin de 300 mg macrolides (also known as azalides and erythromycin) and the sulfonamides. A lot of the time, doctors will say you have to be gabapentin 750 mg pregnant when youre not. ...
Includes information on infection detection and prevention and control, diagnostic technologies, bacteriology, antibacterial, antiviral, antifungal, and antiparasitic agents and susceptibility test methods, virology, mycology, and parasitology.
Includes information on infection detection and prevention and control, diagnostic technologies, bacteriology, antibacterial, antiviral, antifungal, and antiparasitic agents and susceptibility test methods, virology, mycology, and parasitology.
IMPORTANT: There are marked regional and national variations in both parasite fauna and the availability/claims/doses/withhold periods of parasiticides around the world. ALWAYS check the specific product information for the product you are administering and ensure that you comply with local rules. Examples given in this article may be correct for one country but rules may differ in other regions. ...
Petwise is Australias leading wholesaler of livestock parasiticides. Browse our range of cattle tick treatment, sheep tick treatment and much more, and keep your store well-stocked with the essentials. We offer competitive prices and ship nationwide.
Study Flashcards On Antivirals & Antiparasitics at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
TY - JOUR. T1 - Ivermectin. AU - Elgart, George W.. AU - Meinking, Terri L.. PY - 2003/4. Y1 - 2003/4. N2 - Ivermectin is a potent antiparasitic drug and the first commercially available member of a new class of drugs (macrocyclic lactones) that has been approved for human use. Ivermectin has already proven to be highly effective in the elimination of river blindness as a public health burden. Side effects have been minor, and patient acceptance is good. Promising results in off-label applications for ectoparasitic infestations are increasingly important as resistance to topical therapy becomes more prevalent. Ivermectin represents an advance in the therapeutic armamentarium and should be considered in appropriate cases.. AB - Ivermectin is a potent antiparasitic drug and the first commercially available member of a new class of drugs (macrocyclic lactones) that has been approved for human use. Ivermectin has already proven to be highly effective in the elimination of river blindness as a public ...
Parasites can cause nasty infections, but they are actually very similar to our own cells. In this lesson, learn about the types of drugs commonly...
Functionalized quinolines are an important group of heterocyclic molecules with diverse, different, and interesting biological and pharmacological activities. Traditionally, several methods have been developed for the construction of this N-heterocyclic ring, but nowadays the functionalization of the quinoli 2019 Focus and Perspective articles
Six nonsmoking, adult, male volunteers participated in the study. Each subject was judged to be in good health on the basis of a physical examination, clinical
Formalin is a liquid formulation of 37% formaldehyde gas dissolved in water. Two brands of formalin, Formalin-F (Natchez Animal Supply, Natchez, Miss.) and Paracide-F (Argent Chemical Laboratories, Redmond, Wash.), have been approved by FDA as parasiticides for use on fish. Formalin is effective against many external parasites, including protozoans and monogenetic trematodes. It is not generally considered the best treatment for external fungal or bacterial infections. Formalin can be delivered in a short-term bath at a concentration of 250 mg/l - or 150 mg/l if water temperature is greater than 70°F (21°C) - for no more than 60 minutes. It can be delivered as an indefinite bath at a concentration of 15 to 25 mg/l. Formalin is an excellent parasiticide for use in tanks and aquaria, but its use in ponds is discouraged because it chemically removes oxygen from the water and can contribute to catastrophic oxygen depletion under pond conditions. This is avoided in tanks and aquaria by always ...
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Contributing to the complicated nature of pet parasite control, regulation and availability of these products is not uniform. Some products are considered insecticides and, in the United States, are regulated by the Environmental Protection Agency, while others count as medications and fall under the jurisdiction of the U.S. Food and Drug Administration. Some flea-and-tick control methods are available to pet owners over the counter from pet and big-box stores. Others are available only from veterinary clinics or from pharmacies presented with a prescription from a veterinarian who has examined the pet. ...
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Protein Phosphorylation in Parasites Novel Targets for Antiparasitic Intervention by Christian Doerig http://i.imgur.com/3NZhmn5.jpg Pages: 456 Publisher: -- Edition: 1st., 2013
Veterinary Formula Clinical Care Antiparasitic and Antiseborrheic Medicated Shampoo is effective in treating Seborrhea and parasitic and fungal infections.
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Author(s): McKerrow, James H; Lipinski, Christopher A | Abstract: The rule of 5 has become a mainstay of decision-making in the pharmaceutical industry as well as in nonindustrial (academic and institutional) drug development. However the authors of the original paper never intended for double cutoffs to preclude development of new drug leads for parasitic diseases.
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Dr Butters works in the Glycobiology Institute which is headed by Professor Raymond Dwek. His expertise in glycoprotein biology led to him being contacted by Dr Rossignol.. Dr Rossignol approached our group to see if we could help him find a mechanism of action for thiazolides. If we understand the mechanism better, then well be able to improve drug design, explains Dr Butters.. His group works with small molecules that interfere with the cellular processes responsible for glycoprotein production. He is trying to develop these into drugs against the hepatitis C virus which also uses a viral envelope glycoprotein.. If more can be uncovered about how thiazolides work, this may also open up the possibility of using them in combination with compounds Dr Butters own lab is developing.. We have a known mechanism of action for our compounds, and our initial experiments suggest that the drug works in a slightly different way. Both interfere with glycoprotein maturation of viral envelope proteins, ...
TY - JOUR. T1 - Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido based inhibitors of Trypanosoma brucei FolD and testing for antiparasitic activity. AU - Eadsforth, Thomas C.. AU - Pinto, Andrea. AU - Luciani, Rosaria. AU - Tamborini, Lucia. AU - Cullia, Gregorio. AU - De Micheli, Carlo. AU - Marinelli, Luciana. AU - Cosconati, Sandro. AU - Novellino, Ettore. AU - Lo Presti, Leonardo. AU - Cordeiro Da Silva, Anabela. AU - Conti, Paola. AU - Hunter, William N.. AU - Costi, Maria P.. PY - 2015/10/22. Y1 - 2015/10/22. N2 - The bifunctional enzyme N5,N10-methylenetetrahydrofolate dehydrogenase/cyclo hydrolase (FolD) is essential for growth in Trypanosomatidae. We sought to develop inhibitors of Trypanosoma brucei FolD (TbFolD) as potential antiparasitic agents. Compound 2 was synthesized, and the molecular structure was unequivocally assigned through X-ray crystallography of the intermediate compound 3. Compound 2 showed an IC50 of 2.2 μM, against TbFolD and displayed ...
Problem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of the efficacy of ivermectin pour-on administration against natural Heterakis gallinarum infection in native poultry and also determination the prevalence rate of this parasite in Tabriz area. Approach:In the present study, 120 native poultry were investigated by Egg Per Gram of feces (EPG) feces test. Willis method was applied for feces test and Mack-master slide method was used for counting nematode eggs. After confirming the infection with worms, Ivermectin (0.5 mg kg−1) pour-on was administrated to infected birds. Fecal examination was repeated in 1, 7, 21 and 28 days post treatment. Results: Results showed
BioAssay record AID 626318 submitted by ChEMBL: Antiparasitic activity against amastigotes of Leishmania donovani MHOM/ET/67/L82 infected in rat L6 cells after 72 hrs by by Alamar blue assay.
BioAssay record AID 359724 submitted by ChEMBL: Antiparasitic activity against Toxoplasma gondii infected in HFF cells at 0.1 uM after 48 hrs by [3H]uracil incorporation assay relative to control.
NOSB Deliberates. 10:38 a.m. ET: The NOSB reapproves continued use of several other livestock materials, including oxytocin, magnesium sulfate, magnesium hydroxide, iodine, hydrogen peroxide, glycerin, glucose, flunixin, electrolytes, chlorhexidine, and butorphanol.. 10:35 a.m. ET: The NOSB reapproves the continued use of the parasiticide moxidectin. (Cornucopias analysis of the parasiticide issues begins at page 157 here: http://bit.ly/1LxCzWh). 10:33 a.m. ET: More discussion occurred over the parasiticide ivermectin. Members talked about its impact on the environment, effectiveness, and need. Several members noted their reluctance to remove a material used by livestock farmers. When voting took place, 6 supported removal, with only 4 opposing and 4 abstaining. This keeps ivermectin on the National List but again, this would not have been the case had the previous Sunset rules been in place.. 10:29 a.m. ET: The NOSB unanimously reapproves the use of the parasiticide fenbendazole.. 10:01 a.m. ...
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Melbourne researchers say an anti-parasitic drug commonly used to combat head lice has been found to kill the virus that causes COVID-19 in the lab within 48 hours.
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Toxoplasma gondii is an ubiquitous obligate intracellular protozoan parasite that causes permanent infections in 10-30% of humans worldwide. It plays a role as an opportunistic parasite in AIDS patients and can cause eye diseases. T. gondii has veterinary importance and has an important role in abortion and mortality in economic animals like sheep, goats and pigs in all parts of the world. It is also a major cause of foetal abortion in human and other mammals and is associated with some behavioural and neurological effects. Two metabolic enzymes; pantothenate synthase producing the precursor to Coenzyme A, required by 4% of enzymes in eukaryotic cells, and tyrosine-phenylalanine hydroxylase, able to produce tyrosine and L-DOPA, are the main subjects of my study. Co A biosynthesis is likely to be required for parasite growth, but the necessity of tyrosine hydroxylase for parasite growth is less obvious. This study will explain the current knowledge on these enzymes and attempt to evaluate their ...
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Ivermectin, a popular antiparasitic drug was part of the COVID treatment kit until a while ago. However, the early use of the same continues to be seen in many states, which is questionable.. The WHO (World Health Organisation), too, has warned authorities against indiscriminate, radical use of Ivermectin in COVID-19 cases, unless they are part of a clinical trial.. There have been no researches which have held Ivermectin to be safe and effective, or render useful in COVId treatment plans. Not only is the antiparasitic drug known to cause some side effects, global clinical studies observed that the drug carried a lack of safety approach, which made doctors hesitant to dole out the drug. Some doctors also believe that to treat an infection as major as COVID-19, one needs a powerful, stronger dose of a drug like ivermectin, which still may show limited help and falls out of the regulatory limits and may induce toxicity. Hence, ivermectin use has been largely curtailed and shows little to no ...
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Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discovery of innovative drug candidates. A first series of inhibitors has been prepared on the basis of known substrate specificity and the predicted catalytic mechanism of the enzyme. In this Letter we present the first inhibitors of TbMCA2 with low micromolar enzymatic and antiparasitic activity in vitro combined with low cytotoxicity.. ...
Dechra LimePlus Dip is a concentrated sulfurated lime solution for non-specific dermatoses where sulfurated lime is effective. Antifungal - Antiparasitic. Can be used on dogs, cats, puppies, kittens and horses.
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6. Garlic has anti-parasitic and anti-bacterial properties: Garlic has been known throughout the ages to be an effective anti-bacterial and anti-parasitic agent. Garlic extracts or small amounts of garlic in your diet can help you build up immunity and also kill infections within your system effectively. It is also known to be very effective against tapeworm infestations within the gut. ...
A dose-dependent trypanocidal activity of propolis extract was observed in vitro. All trypomastigotes were killed 1 h after incubation with 10 μg mL−1 of the extract. In vivo, the concentrations of 100, 200, 300 and 400 mg kg−1 administered orally for 10 consecutive days showed no curative effect, and the rats died from the disease. However, rats treated with the two highest concentrations of propolis extract showed higher longevity than the other groups ...
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Davis MI, Patrick SL, Blanding WM, Dwivedi V, Suryadi J, Golden JE, Coussens NP, Lee OW, Shen M, Boxer MB, et al. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrobial Agents and Chemotherapy. 2016 ;60:6023-6033. ...
Antiviral, antibacterial, antimicrobial functionReduces the length and severity of a cold or fluEnhances immune system functionStrong antioxidantDescriptionOlive Leaf (Olea europaea) extract exerts powerful antiviral, antibacterial, antifungal, and antiparasitic activity. Anecdotal evidence shows it to be helpful for m
Antiparasitic drugs have been used successfully to control parasitic diseases in animals for many years, as they are safe, cheap and effective against a broad spectrum of parasites. One drawback of this success appears to be the emergence of drug resistance in many target parasites. Moreover, issues of residues in the food chain and environment have arisen, which threaten their sustained use. Control methods in which vaccines would have a central role provide attractive alternatives. However, while attenuated parasite vaccines have been successful, sub-unit vaccines are still rare. The advent of new techniques in molecular biology allows the elucidation of entire parasite genomes and the identification of individual genes. It is envisaged that a further understanding of parasite genes and the role of their products in parasite biology may lead to the identification of useful antigens, which could then be produced in recombinant systems. However, for this aim to be realised, continued investment ...
Vermanth 400 MG Tablet is an antiparasitic drug used in the prevention and treatment of parasitic infections caused by tapeworms, pinworms and hookworms. Buy Vermanth 400 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Download Practo app & get your medicines home delivered.
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Scientific Committee Responsible for oversight of programme, organizing sessions, themes and workshops, developing timetable for each session and inviting speakers. Name Andy Fenton (coinfection) Andy Thompson (protozoa population genomics) Carlos Lanusse (Antiparasitic Drugs Pharmacology) Damer Blake (protozoa and vaccine development) Daniel Masiga, ICIPE, Kenya Diana Williams, Cochair Domenico Otranto (filarial nematodes plus EVPC) Title Dr. Andy Fenton BSc MSc PhD Professor RC Andrew Thompson Professor Carlos Lanusse MedVet DrCsVet PhD DipECVPT Dr. Damer Blake BSc MSc PhD PGCVetEd FHEA Dr. Daniel Masiga BSc Msc PhD (Molecular Parasitology) Professor Diana JL Williams Professor Domenico Otranto BVetMed PhD DipEVPC FRES Affiliations Institute of Integrative Biology, University of Liverpool School of Veterinary and Health Sciences, Murdoch University, Australia Director, Veterinary Research Center, National Council of Scientific and Technical Research, Argentina Senior Lecturer in Molecular ...
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parasiticidal definition: with the capacity of destroying parasites, specifically effective at expelling or destroying parasitic worms.; related to or for the nature of a parasiticide.; effective at expelling…
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Adding prescription medicines as a supplement to dog food can be beneficial. However, with the increasing number of available medicines nowadays, its best to know which are safe for your dog, or not.. Some drugs can prevent diseases while others can cure dog ailments. Thus, you should give the right medicine according to the signs and symptoms present.. Heres a list of medications that may be prescribed for your dog at some point in their life:. Pain Relievers - If your dog is in pain, analgesics are an option. Choosing non-steroidal anti-inflammatory drugs (NSAIDs) is even better to decrease your dogs inflammation. As a result, they can feel a whole lot better.. Sedatives - When your dog is anxious, they may harm themselves with unusual behaviors. Sedatives and other behavior-modifying medicines for dogs can calm them and reduce their strange behavior.. Antiparasitics - This type of medication is one of the most vital medicines your dog needs. It can suppress or kill ticks, fleas, ...
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Problem stomach - I have amibiasis problem stomach problem from many yr. What should I do to recover from that. I get temp relief from tab ciplox tz. Pl reply permanent? Wrong treatment. Ciplox (ciprofloxacin) is an antibiotic used for treatment of bacterial infection. Amoebiasis is caused by e. Histolytica, a protozoan parasite which needs to be treated with an anti-parasitic medication or metronidazole. Would advise confirming diagnosis one year out.
You might not want to use water that is too hot to put into your mouth. If it burns your tongue, it will burn you elsewhere! I m sure parasites are sensitive to hot water! You also might want to try putting some anti-parasitic herbs in your enema, since you are getting worms out that way. In fact, do the anti-parasite program as well as the enema with herbs! You might email Dr. Clark and ask her about what herbs to use in an enema and how to do it. You might want to read ALL of Dr. Hulda Clark s books and make sure you are doing everything there is to do--check her la ...
make sure not to take it after 6pm - see if that doesn t help. Newport s right-on - you probably stirred up some lead and mercury, in which case the vitamin C + MSM will help. Truth be told - I know iodine is an anti-parasitic and what s helped me a good deal is taking a bit of ornithine just before bed. If parasite die-off creates ammonia and ammonia is what Hulda believes (and I do too) creates a great deal of insomnia then it s interesting that I can fall asleep right away after taking ornithine. Makes me think that iodine kills a lot more than we realize (of the bad stuff anyway). ...
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Between 2000 and 2005, twenty new antiparasitic agents were developed or in development.[11] Metal-containing compounds are the ... But heres where it gets crazy! Let me just quote the drug development history of antibiotics/antiparasitic medications:. ... Also LOOK WHOS INVESTING INTO ANTIPARASITIC DRUGS cough PFIZER cough cough along with literally everyone else. Theyre ... Between 1975 and 1999 only 13 of 1,300 new drugs were antiparasitics, which raised concerns that insufficient incentives ...
Ivermectin and praziquantel are antiparasitic agents used to treat the parasitic disease lymphatic filariasis. There are now ...
Such additives include antibacterial agents, antiparasitic compounds, metabolic modifiers, probiotics/prebiotics, acidifiers, ... Such additives include antibacterial agents, antiparasitic compounds, metabolic modifiers, probiotics/prebiotics, acidifiers, ... Such additives include antibacterial agents, antiparasitic compounds, metabolic modifiers, probiotics/prebiotics, acidifiers, ... Pig Feed Antimold Agents For Animal Feed What is the compound feed for piglets and pigs made of, types and the best producers. ...
Bitter taste is a powerful detoxifying agent, and has antibiotic, anti-parasitic, and antiseptic qualities. It is also helpful ...
Allisin is described as antibacterial, antifungal, antiparasitic and anticarsinogenic agent and many works practice on it. But ... Can garlic (Allium sativum) extract be used as scolocidal agent? [Sarimsak (Allium sativum) özütü skolosidal ajan olarak ...
Recently, ivermectin, a broad-spectrum antiparasitic agent, has been used for treatment of mange in dogs. But, it is hard to ...
But this time it is working as an anti-parasitic agent to kill and eliminate parasites. Sources say that a three day pineapple ... which is especially beneficial as an anti-inflammatory agent. Though pineapples do contain citric acid, it isnt nearly as ...
With antiparasitic collar the four-footed friend and not becoming the cause of dangerous diseases, various antiparasitic agents ... The dog is allergic, and besides it had problems with the liver on some antiparasitic agents. The only drawback for me is the ... To prevent mites and fleas from annoying a four-footed friend and not causing dangerous diseases, various antiparasitic agents ... various antiparasitic agents are used. - Stops and prevents infestations - Kills adult fleas, flea eggs, and flea larvae - ...
  • As a potential antileukemic agent, ivermectin induced cell death at low micromolar concentrations in acute myeloid leukemia cell lines and primary patient samples preferentially over normal hematopoietic cells. (ashpublications.org)
  • As an antiparasitic, ivermectin binds and activates chloride ion channels in nematodes, so we tested the effects of ivermectin on chloride flux in leukemia cells. (ashpublications.org)
  • Ivermectin is a broad-spectrum antiparasitic agent. (drugs.com)
  • The pharmacokinetics of the histamine H(1)-antagonist cetirizine and the effects of pretreatment with the antiparasitic macrocyclic lactone ivermectin on the pharmacokinetics of cetirizine were studied in horses. (biomedsearch.com)
  • Ivermectin is the first in a series of antiparasitic agents derived from the avermectin family of compounds. (drugs.com)
  • Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. (ajtmh.org)
  • The widely used antiparasitic agent ivermectin is non-polar and has a high tendency to sorb to surfaces. (springer.com)
  • Ivermectin is one of the most important veterinary and human anti-parasitic agents ever," Mackenzie said. (redorbit.com)
  • Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to pharmacokinetic drug interactions. (vetuk.co.uk)
  • The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and acaricides. (google.com)
  • The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. (google.com)
  • and when R.sup.4 is H, R is H, R.sup.1 is OH, and R.sup.2 is not 2-buten-2-yl, 2-penten-2-yl or 4-methyl-2-penten-2-yl.The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and acaricides. (patentgenius.com)
  • This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but having a novel substituent group at the 25-position and to a process for their preparation. (google.com)
  • The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents. (patentsencyclopedia.com)
  • Disclosed compounds with modifications of the pentose ring aimed to mimic ATP, are only expected to have an antiparasitic activity. (archives-ouvertes.fr)
  • The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed. (google.com)
  • To identify known drugs with previously unrecognized anticancer activity, we compiled and screened a library of such compounds to identify agents cytotoxic to leukemia cells. (ashpublications.org)
  • In addition, several compounds of natural origin have also shown in vitro antiparasitic activity: the polyphenols mangiferin and (-)-epigallocatechin-3-gallate (EGCG), curcumin, resveratrol and the synthetic polyphenol propyl gallate. (wikipedia.org)
  • These enzymes have therefore emerged as promising targets for antiparasitic drugs. (nih.gov)
  • These data, in conjunction with comparative inhibition kinetics, provide insight into the molecular mechanisms that drive cysteine protease inhibition by vinyl sulfones, the binding specificity of these important proteases and the potential of vinyl sulfones as antiparasitic drugs. (nih.gov)
  • Other major antiprotozoal drugs are also reviewed, including those used for malaria, infections with gastrointestinal protozoa, leishmaniasis, and trypanosomiasis, but an exhaustive list of all antiparasitic drugs is not included. (monash.edu)
  • Throughout this chapter, we indicate which antiparasitic drugs are currently approved by the U.S. Food and Drug Administration (FDA). (monash.edu)
  • The antiparasitic drugs can be divided into antiprotozoal and antihelminthic drugs. (china-sinoway.com)
  • Porto I. Antiparasitic drugs and lactation: focus on anthelmintics, scabicides, and pediculicides. (nih.gov)
  • Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. (wikipedia.org)
  • In particular the interaction of novel antiparasitic agents with DNA (the subject of a European Community Cost Action) with the aim of developing new drugs for the treatment of parasitic diseases ref. (pharmweb.net)
  • Treatments for Chagas disease have been administered since the first attempts by Mayer & Rocha Lima (1912, 1914) and up to the drugs currently in use (nifurtimox and benznidazole), along with potential drugs such as allopurinol and first, second and third-generation antifungal agents (imidazoles and triazoles), in separate form. (bioline.org.br)
  • Recent developments in antiparasitic therapy include the expansion of artemisinin-based therapies for malaria, new drugs for soil-transmitted helminths and intestinal protozoa, expansion of the indications for antiparasitic drug treatment in patients with Chagas disease, and the use of combination therapy for leishmaniasis and human African trypanosomiasis. (pubmedcentralcanada.ca)
  • Antiparasitic agents: new drugs on the horizon. (semanticscholar.org)
  • Increased resistance of the parasite and the side-effects of the reference drugs employed in the treatment of giardiasis make necessary to seek new therapeutic agents. (scielo.br)
  • The last group of patents consists of carboxamidines and inhibitors of nucleoside transporters with potential antiparasitic effect. (archives-ouvertes.fr)
  • Additionally, antibacterial and antifungal agents that can also be used for treatment of protozoal infections, such as the 5-nitroimidazoles, trimethoprim-sulfamethoxazole, azithromycin, and amphotericin, are not discussed in detail here, but their general indications for parasitic infections are shown in Tables 1 and 2. (monash.edu)
  • These studies demonstrate that atovaquone has pronounced in vitro and in vivo antifungal activity against filamentous fungi by disrupting both metal homeostasis and mitochondrial function, and therefore has potential as a novel antifungal agent. (arvojournals.org)
  • Among the patents disclosed recently, only iminoribitol derivatives have documented antiparasitic activities, especially against nucleoside N-hydrolases (NH), purine nucleoside phosphorylase (PNP) and also against 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP), an enzyme at the border of polyamine biosynthesis and purine salvage. (archives-ouvertes.fr)
  • Together with other significant structural differences, this provides a possible explanation of the lower affinity of the parasite ENR enzyme family for aminopyridine-based inhibitors, suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials. (strath.ac.uk)
  • The aim of this study was to evaluate the toxicity of parasiticides agent, antimicrobials agent and insecticides on A. franciscana to establish Predicted No-Effect Concentration (PNEC) on marine organisms and obtain guidance levels for the protection of aquatic life. (edu.pe)
  • In this paper, we aim to present an updated overview of in vitro and in vivo studies that show the significant therapeutic properties of the crude extracts and phytochemicals derived from H. sabdariffa as antimicrobial, antiparasitic, and anticancer agents. (prolekare.cz)
  • We have characterized the antibiotic megalomicin (MGM) as an antiparasitic drug against several taxonomically distant parasites. (asm.org)
  • In case of identification of the causative pathogen, an antibiotic or an anti-parasitic agent may be used. (news-medical.net)
  • However, the lack of financial incentives to develop new agents is a major limitation to the future of antiparasitic chemotherapy. (monash.edu)
  • Its antiparasitic mechanism of action is through binding selectively to certain ion channels present in invertebrate nerve and muscle cells but not present in mammals. (fiercebiotech.com)
  • Parasite biochemical pathways are sufficiently different from the human host to allow selective interference by chemotherapeutic agents in relatively small doses. (medscape.com)
  • Here we report that guanabenz, an FDA-approved drug that interferes with translational control, has antiparasitic activity against replicative stages of Toxoplasma and the related apicomplexan parasite Plasmodium falciparum (a malaria agent). (asm.org)
  • Antiparasitic agents are important both for therapy of infected individual patients and for control of parasitic infections at the community level. (monash.edu)
  • Emerging resistance among parasites, lack of effective antiparasitic vaccines, and the enormous burden of disease worldwide also pose challenges to the effective management of parasitic infections. (monash.edu)
  • Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. (wikipedia.org)
  • Numerous studies have described the potential use of HSE and its phytochemicals as significant antimicrobial and antiparasitic agents in the treatment of various infections. (prolekare.cz)
  • Corticosteriods, antihistamines, or other antiinflammatory agents (i.e., aspirin) may be prescribed concurrently in serious infections to reduce the likelihood of a Mazzotti reaction. (pdr.net)
  • In particular, antibacterial agents are incredibly important worldwide, with the emergence of multi-drug resistant bacteria. (rsc.org)
  • Another agent, nitazoxanide, has both anthelmintic and antiprotozoal activity and is also discussed. (monash.edu)
  • Nitazoxanide is the only broad-spectrum antiparasitic drug that has been approved in the United States for treatment of cryptosporidiosis. (cdc.gov)
  • Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. (wikipedia.org)
  • Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (labome.org)
  • 21. The pharmaceutical composition according to claim 20 further comprising a second therapeutic agent. (patentsencyclopedia.com)
  • The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery. (benthamscience.com)
  • The Antiparasitic Agents market report addresses forecast and growth patterns by company, regions and type or application from 2017 to 2021. (medgadget.com)
  • Eurytrema coelomaticum is a digenean flatworm of ruminants that is the causative agent of eurytrematosis, a disease of veterinary health concern. (usda.gov)
  • The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and spring 2000 in turbot (Scophthalmus maximus) cultivated in the Atlantic Ocean (Galicia, Northwest Spain). (wikipedia.org)
  • Its convenience, broad spectrum efficacy and wide safety margin make it an excellent antiparasitic product for horses. (drugs.com)
  • If the cause of the diarrhea is detected, and it is due to bacteria or parasites, agents useful against these pathogens may be used. (news-medical.net)
  • This chapter focuses on the mechanisms of action, pharmacology, clinical utility, and adverse effects of common first-line antiparasitic therapies and newer drug alternatives. (monash.edu)
  • Tonic water contains approximately 80 mg/L quinine sulphate as a flavouring agent. (inchem.org)
  • Malaria remains one of the most important diseases of humans in terms of both mortality and morbidity, with Plasmodium falciparum being the most important infecting agent ( 24 ). (asm.org)
  • Due to the effects of MGM on the Golgi and on the replication of enveloped viruses, we decided to test whether it has any antiparasitic activity. (asm.org)
  • The flagellated protozoan Trypanosoma cruzi is the etiologic agent of American trypanosomiasis (Chagas' disease), a major public health problem in many Latin American countries, with an estimated 15 million people infected. (asm.org)
  • Antiparasitic Agents, Vitamins, Amino Aci. (weiku.com)
  • Our findings suggest that guanabenz can be repurposed into an effective antiparasitic with a unique ability to reduce tissue cysts in the brain. (asm.org)
  • In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. (ebi.ac.uk)

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