Drugs used to treat or prevent parasitic infections.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Substances that are destructive to protozoans.

Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (1/370)

OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.  (+info)

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (2/370)

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs.  (+info)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (3/370)

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.  (+info)

Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. (4/370)

In persons with onchocerciasis, topical application of the anthelminthic diethylcarbamazine (DEC) induces clinical and histologic responses similar to acute papular onchodermatitis, including recruitment of eosinophils to the skin. To determine whether the eosinophil chemokine eotaxin is likely to be associated with eosinophil recruitment in onchodermatitis, DEC was applied to a 5-cm2 area on the skin of infected persons, and biopsies were taken from lesions 24 h later. Histologic analysis showed elevated dermal and epidermal eosinophils compared with tissue from an adjacent (untreated) site. Reverse transcription-polymerase chain reaction showed that eotaxin gene expression in DEC-treated skin was elevated 2- to 17-fold compared with control tissue. Eotaxin immunoreactivity was noted in mononuclear cells and eosinophils in the perivascular region of the dermis and in lymphatic and vascular endothelial cells. Together, these observations are consistent with a role for eotaxin in recruitment of eosinophils to the dermis in early stage onchocercal skin disease.  (+info)

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. (5/370)

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decreased locomotion, and bang sensitivity. Binding assays using glc(1) head membranes showed a marked decrease in the affinity for nodulisporic acid and ivermectin. A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was introduced into a recombinant DmGluClalpha, and RNA encoding wild-type and mutant subunits was injected into Xenopus oocytes. Nodulisporic acid directly activated wild-type and mutant DmGluClalpha channels. However, mutant channels were approximately 10-fold less sensitive to activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providing direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.  (+info)

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons. (6/370)

The gamma-aminobutyric acid (GABA) receptor is an important site of action of a variety of chemicals, including barbiturates, benzodiazepines, picrotoxin, bicuculline, general anesthetics, alcohols, and certain insecticides. Fipronil is the first phenylpyrazole insecticide introduced for pest control. It is effective against some insects that have become resistant to the existing insecticides. To elucidate the mechanism of fipronil interaction with the mammalian GABA system, whole-cell patch-clamp experiments were performed using rat dorsal root ganglion neurons in primary culture. Fipronil suppressed the GABA-induced whole-cell currents reversibly in both closed and activated states. The IC(50) values and Hill coefficients for fipronil block of the GABA(A) receptor were estimated to be 1.66 +/- 0.18 microM and 1.23 +/- 0.14 for the closed receptor, respectively, and 1.61 +/- 0.14 microM and 0.96 +/- 0.06 for the activated receptor, respectively. The association rate and dissociation rate constants of fipronil effect were estimated to be 673 +/- 220 M(-1) s(-1) and 0.018 +/- 0.0035 s(-1) for the closed GABA(A) receptor, respectively, and 6600 +/- 380 M(-1) s(-1) and 0.11 +/- 0.0054 s(-1) for the activated GABA(A) receptor, respectively. Thus, both the association and dissociation rate constants of fipronil for the activated GABA(A) receptor are approximately 10 times as large as those for the closed receptor. Experiments with coapplication of fipronil and picrotoxinin indicated that they did not compete for the same binding site to block the receptor. It is concluded that although fipronil binds to the GABA(A) receptor without activation, channel opening facilitates fipronil binding to and unbinding from the receptor.  (+info)

GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. (7/370)

1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects. 2. Expression of glc-3 cRNA in XENOPUS oocytes resulted in the formation of homo-oligomeric L-glutamate-gated chloride channels with robust and rapidly desensitizing currents, an EC(50) of 1.9+/-0.03 mM and a Hill coefficient of 1.5+/-0.1. GABA, glycine, histamine and NMDA all failed to activate the GLC-3 homo-oligomer at concentrations of 1 mM. The anthelminthic, ivermectin, directly and irreversibly activated the L-glutamate-gated channel with an EC(50) of 0.4+/-0.02 microM. 3. The GLC-3 channels were selective for chloride ions, as shown by the shift in the reversal potential for L-glutamate-gated currents after the reduction of external Cl(-) from 107.6 to 62.5 mM. 4. Picrotoxinin failed to inhibit L-glutamate agonist responses at concentrations up to 1 mM. The polycyclic dinitrile, 3,3-bis-trifluoromethyl-bicyclo[2,2,1]heptane-2,2-dicarbonitrile (BIDN), completely blocked L-glutamate-induced chloride currents recorded from oocytes expressing GLC-3 with an IC(50) of 0.2+/-0.07 microM. The phenylpyrazole insecticide, fipronil, reversibly inhibited L-glutamate-gated currents recorded from the GLC-3 receptor with an IC(50) of 11.5+/-0.11 microM. 5. In this study, we detail the unusual antagonist pharmacology of a new GluCl subunit from C. elegans. Unlike all other native and recombinant nematode GluCl reported to date, the GLC-3 receptor is insensitive to picrotoxinin, but is sensitive to two other channel blockers, BIDN and fipronil. Further study of this receptor may provide insights into the molecular basis of non-competitive antagonism by these compounds.  (+info)

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. (8/370)

The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several techniques including DNA fragmentation assay and in situ and cytofluorometry terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling methods and YOPRO-1 staining allowed us to demonstrate that potassium antimonyl tartrate, an Sb(III)-containing drug, was able to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum at low concentrations (10 microg/ml). This observation was in close correlation with the toxicity of Sb(III) species against axenic amastigotes (50% inhibitory concentration of 4.75 microg/ml). Despite some similarities to apoptosis, nuclease activation was not a consequence of caspase-1, caspase-3, calpain, cysteine protease, or proteasome activation. Altogether, our results demonstrate that the antileishmanial toxicity of Sb(III) antimonials is associated with parasite oligonucleosomal DNA fragmentation, indicative of the occurrence of late events in the overall process of apoptosis. The elucidation of the biochemical pathways leading to cell death could allow the isolation of new therapeutic targets.  (+info)

Antiparasitic agents are a type of medication used to treat parasitic infections. These agents include a wide range of drugs that work to destroy, inhibit the growth of, or otherwise eliminate parasites from the body. Parasites are organisms that live on or inside a host and derive nutrients at the host's expense.

Antiparasitic agents can be divided into several categories based on the type of parasite they target. Some examples include:

* Antimalarial agents: These drugs are used to treat and prevent malaria, which is caused by a parasite that is transmitted through the bites of infected mosquitoes.
* Antiprotozoal agents: These drugs are used to treat infections caused by protozoa, which are single-celled organisms that can cause diseases such as giardiasis, amoebic dysentery, and sleeping sickness.
* Antihelminthic agents: These drugs are used to treat infections caused by helminths, which are parasitic worms that can infect various organs of the body, including the intestines, lungs, and skin. Examples include roundworms, tapeworms, and flukes.

Antiparasitic agents work in different ways to target parasites. Some disrupt the parasite's metabolism or interfere with its ability to reproduce. Others damage the parasite's membrane or exoskeleton, leading to its death. The specific mechanism of action depends on the type of antiparasitic agent and the parasite it is targeting.

It is important to note that while antiparasitic agents can be effective in treating parasitic infections, they can also have side effects and potential risks. Therefore, it is essential to consult with a healthcare provider before starting any antiparasitic medication to ensure safe and appropriate use.

Ivermectin is an anti-parasitic drug that is used to treat a variety of infections caused by parasites such as roundworms, threadworms, and lice. It works by paralyzing and killing the parasites, thereby eliminating the infection. Ivermectin is available in various forms, including tablets, creams, and solutions for topical use, as well as injections for veterinary use.

Ivermectin has been shown to be effective against a wide range of parasitic infections, including onchocerciasis (river blindness), strongyloidiasis, scabies, and lice infestations. It is also being studied as a potential treatment for other conditions, such as COVID-19, although its effectiveness for this use has not been proven.

Ivermectin is generally considered safe when used as directed, but it can cause side effects in some people, including skin rashes, nausea, and diarrhea. It should be used with caution in pregnant women and people with certain medical conditions, such as liver or kidney disease.

Antiprotozoal agents are a type of medication used to treat protozoal infections, which are infections caused by microscopic single-celled organisms called protozoa. These agents work by either killing the protozoa or inhibiting their growth and reproduction. They can be administered through various routes, including oral, topical, and intravenous, depending on the type of infection and the severity of the illness.

Examples of antiprotozoal agents include:

* Metronidazole, tinidazole, and nitazoxanide for treating infections caused by Giardia lamblia and Entamoeba histolytica.
* Atovaquone, clindamycin, and pyrimethamine-sulfadoxine for treating malaria caused by Plasmodium falciparum or other Plasmodium species.
* Pentamidine and suramin for treating African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense or T. b. rhodesiense.
* Nitroimidazoles, such as benznidazole and nifurtimox, for treating Chagas disease caused by Trypanosoma cruzi.
* Sodium stibogluconate and paromomycin for treating leishmaniasis caused by Leishmania species.

Antiprotozoal agents can have side effects, ranging from mild to severe, depending on the drug and the individual patient's response. It is essential to follow the prescribing physician's instructions carefully when taking these medications and report any adverse reactions promptly.

Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ... Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic". In Sigel, ... Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. Metal-containing compounds are the ... Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ...
Kuhlmann FM, Fleckenstein JM (2017-01-01). "157 - Antiparasitic Agents". In Cohen J, Powderly WG, Opal SM (eds.). Infectious ... Approaches to Design and Synthesis of Antiparasitic Drugs. Vol. 25. Elsevier. p. 428. doi:10.1016/S0165-7208(97)80039-6. ISBN ... Antiprotozoal agents, Disulfiram-like drugs, Poultry diseases, Nitroimidazole antibiotics, Organochlorides, Halohydrins, All ... stub articles, Antiinfective agent stubs, Genito-urinary system drug stubs). ...
doi:10.1007/s00436-009-1371-7. (Antiparasitic agents, Lists of drugs). ... MeSH list of agents 82012556 McMahon JE, Kolstrup N (December 1979). "Praziquantel: a new schistosomicide against Schistosoma ...
Campbell WC, Fisher MH, Stapley EO, Albers-Schönberg G, Jacob TA (August 1983). "Ivermectin: a potent new antiparasitic agent ... from an antiparasitic agent to a repositioned cancer drug". American Journal of Cancer Research. 8 (2): 317-331. PMC 5835698. ... Food and Drug Administration as an antiparasitic agent. In 2020, it was the 423rd most commonly prescribed medication in the ... Antiparasitic agents, GABAA receptor positive allosteric modulators, Glycine receptor agonists, Insecticides, Japanese ...
"Ivermectin as an antiparasitic agent in horses". J S Afr Vet Assoc (Review). 53 (2): 127-8. PMID 6750120. Matthews JB (December ... Ivermectin is one of the most effective antiparasitics used for horses. It can be used for a wide range of targets including ... Drug resistance is a growing concern for antiparasitic medications. Resistance has been noted with ivermectin to ascarids, and ...
Arylmethylamino steroids as antiparasitic agents. Nature Communications 8:14478, 2017. doi: 10.1038/ncomms14478. "DFG - ...
... [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Oral nitazoxanide is an available, approved antiparasitic agent (e.g., against cryptosporidium, giardia) with established ... a new broad spectrum antiparasitic agent". Expert Review of Anti-Infective Therapy. 2 (1): 43-49. doi:10.1586/14787210.2.1.43. ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed ...
Mallo, Natalia; Lamas, Jesús; Leiro, José M. (2014). "Alternative oxidase inhibitors as antiparasitic agents against ... Mallo, N.; Defelipe, A. P.; Folgueira, I.; Sueiro, R. A.; Lamas, J.; Leiro, J. M. (2017). "Combined antiparasitic and anti- ... The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and ... In addition, several compounds of natural origin have also shown in vitro antiparasitic activity: the polyphenols mangiferin ...
... is a fungus species of the genus of Penicillium which produces the antinematodal and antiparasitic agents ... Liesch, J. M.; Wichmann, C. F. (1990). "Novel antinematodal and antiparasitic agents from Penicillium charlesii. II. Structure ...
Hotson, I. K. (1982). "The avermectins: A new family of antiparasitic agents". Journal of the South African Veterinary ... New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation". Antimicrobial Agents and Chemotherapy. 15 (3): ... Ivermectin has improved the lives of billions of people worldwide and not solely for uses as an anti parasitic. Milbemycins are ...
Antiparasitic Agents". emedicine.medscape.com. Retrieved 27 November 2020. "Pyrethrin and Piperonyl Butoxide Topical: ...
It covers antimicrobial, antiviral, antifungal, and antiparasitic agents and chemotherapy. The editor-in-chief is Cesar A. ... Antimicrobial Agents and Chemotherapy is a peer-reviewed scientific journal published by the American Society for Microbiology ... "New Editors-in-Chief Announced for ASM's Antimicrobial Agents and Chemotherapy and Microbiology and Molecular Biology Reviews ...
Green synthesized gold nanoparticles as antifungal and anti-parasitic agents. Department of Pharmacy Practice It started ...
Campbell, William C. (2016-02-15). "Lessons from the History of Ivermectin and Other Antiparasitic Agents". Annual Review of ... S. haematobium, the infectious agent responsible for urogenital schistosomiasis, infects over 112 million people annually in ...
... antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...
FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in ... For this reason, several FTase inhibitors are undergoing testing as anti-cancer agents. ...
... a Novel Antiparasitic Agent". Antimicrobial Agents and Chemotherapy. 61 (1): e01947-16. doi:10.1128/AAC.01947-16. PMC 5192119. ... Barrios contributed to the development of a new anti-parasitic drug. Through a high-throughput drug screen, they found that ...
Many commonly used antimicrobial, antiparasitic, and anticancer agents are polyketides or polyketide derivatives, such as ... "Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents". Current ...
"Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent". Frontiers in Cellular and Infection ... Various clinical trials of copper depletion agents have been carried out.[citation needed] In the body, disulfiram is rapidly ... Disulfiram has also been identified by systematic high-throughput screening as a potential HIV latency reversing agent (LRA). ... Disulfiram is also being investigated in combination with vorinostat, another investigational latency reversing agent, to treat ...
They are used in veterinary medicine as antiparasitic agents against worms, ticks and fleas. Like avermectins, milbemycins are ...
"Potential of Terpenoids and Flavonoids from Asteraceae as Anti-Inflammatory, Antitumor, and Antiparasitic Agents". National ...
The broad-spectrum antiparasitic agent nitazoxanide has shown efficacy against many diarrhea-causing parasites. Other ... Anti-motility agents like loperamide are also effective at reducing the number of stools but not the duration of disease. These ... Another absorbent agent used for the treatment of mild diarrhea is kaopectate. Racecadotril an antisecretory medication may be ... In most of these cases, osmotic diarrhea stops when the offending agent, e.g. milk or sorbitol, is stopped. Exudative diarrhea ...
"Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin". ...
This makes it an ideal target for new antimicrobial agents, anti-parasitic agents, and herbicides. Other enzymes in the ...
Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic". In Sigel A, ... Several agents, all sustained by a plausible biological rationale, have been evaluated. Evidence from meta-analyses showed that ... Other antifungal agents clotrimazole and ketoconazole have been investigated for anti-trypanosome therapy. Successful ...
... s belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic ...
A clinical trial of another anti-parasitic agent, moxidectin (manufactured by Wyeth), began on July 1, 2009 (NCT00790998). A ... The key factor in elimination is mass administration of the antiparasitic drug ivermectin. The initial projection was that the ...
... or antiprotistal refers to an anti-parasitic and anti-infective agent which is active against protists. ... MeSH list of agents 82000563 v t e (Articles to be expanded from October 2021, All stub articles, Antiinfective agent stubs, ...
Menaker treated sparrows with Dry-Die, an anti-parasitic agent, to eliminate any possible effects of light transferring by ...
Ivermectin has become the most common antiparasitic agent used worldwide, but can lead to residual microfilarial load when ...
Antibiotic and antiparasitics agents. Class Summary. Antimicrobial agents, in addition to the immune system, help destroy ... Antiparasitic agent with wide coverage. Nitrofuran with antiprotozoal activity. Alternative drug for children because ... Agents for whom antimi-crobial therapy is indicated only in selected circumstances, include the following:. * Infections by ... Agents for whom antimicrobial therapy is always indicated: The consensus includes only V cholerae, Shigella species, and G ...
Antiparasitic agents. Class Summary. These agents are used to speed the pace of worm extraction. ...
Ivermectin is part of the broader class of avermectins that are veterinary and human antiparasitic agents. Avermectins were ... Ivermectin - broad spectrum anti-parasitic agent first approved for use. *. June 21, 1981. ... Ivermectin is part of the broader class of avermectins that are veterinary and human antiparasitic agents. Avermectins were ...
Synthesis and Evaluation of (Bis)benzyltetrahydroisoquinoline Alkaloids as Antiparasitic Agents Sozanschi A., Asiki H., Amaral ...
Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ... Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic". In Sigel, ... Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. Metal-containing compounds are the ... Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ...
2011;19:314-20.) Corticosteroids are sometimes prescribed in addition to antiparasitic agents. ...
LR: 20160319; CI: (c) The American Society of Tropical Medicine and Hygiene.; JID: 0370507; 0 (Antiparasitic Agents); ...
Categories: Antiparasitic Agents Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
... potent antiparasitic agents such as formalin and metronidazole; a good antifungal agent; and broad-spectrum antibiotics. And ... Antiparasitic for treating internal parasites (i.e., praziquantel or metronidazole); Broad-Spectrum Antibiotics (e.g., ... And you can get a wide range of antiparasitics, anti-fungals, and antibiotics, including pretty much all the medications on my ... Thus, when combined with a good antiparasitic medication like Acriflavine, a good combination drug like Furan2 can be the ...
Police said benzylpiperazine was a synthetic drug developed as a potential antiparasitic agent and listed as a prohibited drug ...
"Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin". ...
Antiparasitic agents [1]. Author index [1]. Bacteriology [1]. Bile flow [1]. Blood -- Diseases [2]. ...
Administered parenteral (IV or intramuscular) antibacterial, antiviral, antifungal, or antiparasitic agents ,=30 days before ...
"Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin". ...
... is scientific evidence based on physiological studies and this should be taken into account when using antiparasitic agents for ... Antiparasitic drug Ivermectin kills coronavirus in 48 hours Around the world, scientists race to develop a vaccine or treatment ... University of Alicante study: Antiparasitic Ivermectin six times more toxic than Moxidectin Ivermectin is six times more toxic ... New method spurs production of antibiotic or antiparasitic compounds in actinobacteria Researchers have developed a method to ...
Along with it, scientists have discovered other anti-parasitic agents that could be used against malaria or sleeping sickness ...
Appropriate vaccination, administration of anti-parasitic agents, diagnostic testing, and housing of animals upon admission are ...
Research, Technology, Methods , drugs , anti-infective agents , antiparasitic agents , ectoparasiticides. Preferred Term: ...
... containing the potent antiparasitic agent ivermectin, has revolutionized the treatment of various parasitic infections. Its ...
Both patients were treated with ventriculoperitoneal shunt, systemic antiparasitic agents, and immunosuppression.EPNCC is less ...
As outcomes, we considered only prescriptions for antibacterial agents (Table 1); other prescriptions, including antimalarial ... and antiparasitic medications, were excluded. Prescription of CPT was not considered an outcome. ...
The shipment, which will be received by the Mumbai Public Health Department, includes anti-infective and anti-parasitic agents ... The shipment, which will be received by the Mumbai Public Health Department, includes anti-infective and anti-parasitic agents ...
Antiparasitic agents, 19 = Respiratory tract drugs, 20 = Unclassified/miscellaneous, 21 = Homeopathic products. RELATIVE ... ANTIDEPRESSANT AGENT 35420 ANTIDIABETIC AGENT 35430 ANTIEMETIC AGENT 35440 ANTIFLATULENT AGENT 35445 ANTIFUNGAL AGENT 35450 ... ANTILIPEMIC AGENT 35480 ANTINEOPLASTIC AGENT 35483 ANTIOBESITY AGENT 35495 ANTIPYRETIC AGENT 35500 ANTITHYROID AGENT 35530 ... Metabolic and nutrient agents, 10 = Hormones and agents affecting hormonal mechanisms, 11 = Immunologic agents, 12 = Skin/ ...
Other reports have revealed that these molecules are also present in a variety of antiparasitic and herbicidal agents. ...
... it has achieved the status of the most revolutionary antiparasitic agent to be introduced in the 1980s. For anthelmintic ... it has achieved the status of the most revolutionary antiparasitic agent to be introduced in the 1980s. For anthelmintic ... Ecotoxicity of antiparasitics: optimization of the use of pharmaceutical forms of ivermectin and its analogues. en fr ... Ecotoxicity of antiparasitics: optimization of the use of pharmaceutical forms of ivermectin and its analogues. [Rapport de ...
Section F: Antiparasitic Agents. 183 Albendazole 247. 184 Atovaquone 249. 185 Fenbendazole 251 ... Provides fast access to essential information on prescribing antibiotics, antifungals, antiparasitics, and antivirals ...
... which belongs to a class of drugs known as antiparasitic agents. It is primarily used to treat infections caused by certain ... Stromectol is an antiparasitic medication that is commonly used for the treatment of certain worm infections. However, it is ... Stromectol is an antiparasitic medication used to treat various types of parasitic infections in humans. It contains the active ...
... and create a QSAR model that can be used for the development of clinically useful antiparasitic agents. In this study, we have ... As it is not understood which molecular features of 1 are important for the antiparasitic activity, several analogues were ... All 27 compounds, including the two natural products 1 and 5a, were subsequently assayed in vitro for antiparasitic activity ... Pulchrol (1) is a natural benzochromene isolated from the roots of Bourreria pulchra, shown to possess potent antiparasitic ...
6 This form of empiric swapping of an agent is reasonable for antibiotics but not for antiparasitic or antifungal agents ... WHEN TO CHANGE THE ANTIMICROBIAL AGENT It can be tempting to swap antimicrobial agents or add various alternative agents if the ... Treatment with the wrong agent can be harmful. It can, for example, contribute to epithelial toxicity, cloud the clinical ... these regimens have somewhat different sensitivities for different bacteria5 and that alterations in the antibacterial agent ...
  • Pulchrol (1) is a natural benzochromene isolated from the roots of Bourreria pulchra, shown to possess potent antiparasitic activity towards both Leishmania and Trypanozoma species. (lu.se)
  • Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic medication. (news-medical.net)
  • Stromectol is an antiparasitic medication used to treat various types of parasitic infections in humans. (tangorm.com)
  • Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. (news-medical.net)
  • Use additional code (U80-U89), (U82-U84), if desired, to identify the antibiotic to which a bacterial agent is resistant. (who.int)
  • Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases, such as those caused by helminths, amoeba, ectoparasites, parasitic fungi, and protozoa, among others. (wikipedia.org)
  • It is a potent external fungicide, external protozoacide, and antiparasitic, and seahorse keepers commonly use formalin to cleanse new arrivals of ectoparasites during quarantine. (seahorse.com)
  • Antiparasitics are one of the antimicrobial drugs which include antibiotics that target bacteria, and antifungals that target fungi. (wikipedia.org)
  • Broad-Spectrum antiparasitics, analogous to broad-spectrum antibiotics for bacteria, are antiparasitic drugs with efficacy in treating a wide range of parasitic infections caused by parasites from different classes. (wikipedia.org)
  • Ivermectin is part of the broader class of avermectins that are veterinary and human antiparasitic agents. (agrodiv.org)
  • All 27 compounds, including the two natural products 1 and 5a, were subsequently assayed in vitro for antiparasitic activity against Trypanozoma cruzi, Leishmania brasiliensis and Leishmania amazoniensis. (lu.se)
  • Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (bvsalud.org)
  • Another possible application of this kind of extract could be its use as an antimicrobial or even antiparasitic therapeutic agent, although it is purely speculative. (johnshopkins.edu)
  • L'INRA et l'ENVT ont étudié et documenté les expositions internes et les éliminations fécales en IVM associées à ces formes galéniques, car ces connaissances sont indispensables pour répondre à des enjeux de santé publique en anticipant d'éventuels problèmes de sûreté (hygiène) alimentaire pour le consommateur, de toxicité pour l'animal et pour l'environnement, et d'efficacité (résistance des parasites). (inrae.fr)
  • Resistance to antiparasitics has been a growing concern, especially in veterinary medicine. (wikipedia.org)
  • Gentian violet and malachite green are also antifungal, antiparasitic, and antibacterial agents used in veterinary medicine. (who.int)
  • Agents for whom antimicrobial therapy is always indicated: The consensus includes only V cholerae , Shigella species, and G lamblia . (medscape.com)
  • Overuse or misuse of antiparasitics can lead to the development of antimicrobial resistance. (wikipedia.org)
  • This indicates that the causative agents of diarrhoea and Methods their environmental sources are still with us. (who.int)
  • Bronchodilators and anti-inflammatory environmental irritants, viral infections, agents were the most common medications prescribed. (cdc.gov)
  • Researchers in Argentina have conducted a pre-clinical study demonstrating the safety and pharmacokinetic performance of a new nasal spray formulation designed to suppress the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19). (news-medical.net)
  • Police said benzylpiperazine was a synthetic drug developed as a potential antiparasitic agent and listed as a prohibited drug in NSW. (smh.com.au)
  • Antimicrobial agents, in addition to the immune system, help destroy offending organisms. (medscape.com)
  • Conclusions --The patient populations receiving care for asthma vary (anti-inflammatory agents) or open the depending on the ambulatory care setting. (cdc.gov)
  • types of anti-inflammatory agents. (cdc.gov)
  • Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. (wikipedia.org)
  • As it is not understood which molecular features of 1 are important for the antiparasitic activity, several analogues were synthesized and assayed. (lu.se)
  • The ultimate goal is to understand the structure-activity relationships (SAR:s) and create a QSAR model that can be used for the development of clinically useful antiparasitic agents. (lu.se)
  • Corticosteroids are sometimes prescribed in addition to antiparasitic agents. (cdc.gov)
  • Other reports have revealed that these molecules are also present in a variety of antiparasitic and herbicidal agents. (farmavita.net)
  • Between 1975 and 1999 only 13 of 1,300 new drugs were antiparasitics, which raised concerns that insufficient incentives existed to drive development of new treatments for diseases that disproportionately target low-income countries. (wikipedia.org)
  • Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. (wikipedia.org)
  • Appropriate vaccination, administration of anti-parasitic agents, diagnostic testing, and housing of animals upon admission are discussed. (maddiesfund.org)
  • The shipment, which will be received by the Mumbai Public Health Department, includes anti-infective and anti-parasitic agents, analgesics, oral rehydration salts, and water purification tablets. (directrelief.org)
  • However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. (bvsalud.org)
  • Early antiparasitics were ineffective, frequently toxic to patients, and difficult to administer due to the difficulty in distinguishing between the host and the parasite. (wikipedia.org)