Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Ivermectin: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.Antiprotozoal Agents: Substances that are destructive to protozoans.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Onchocerciasis: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Heliotropium: A plant genus in the family Boraginaceae, order Lamiales, subclass Asteridae. This is the True Heliotrope that should not be confused with an unrelated plant sometimes called Garden Heliotrope (VALERIAN).Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.Insurance, Health, Reimbursement: Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)Competitive Bidding: Pricing statements presented by more than one party for the purpose of securing a contract.Purchasing, Hospital: Hospital department responsible for the purchasing of supplies and equipment.Cyclotides: A continuous circle of peptide bonds, typically of 2-3 dozen AMINO ACIDS, so there is no free N- or C-terminus. They are further characterized by six conserved CYSTEINE residues that form CYSTINE KNOT MOTIFS.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Chromatography: Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.Cell Fractionation: Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.Cryptosporidiosis: Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.ThiazolesCryptosporidium parvum: A species of parasitic protozoa that infects humans and most domestic mammals. Its oocysts measure five microns in diameter. These organisms exhibit alternating cycles of sexual and asexual reproduction.Artemisinins: A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).Antimalarials: Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)Fluorenes: A family of diphenylenemethane derivatives.Cameroon: A republic in central Africa lying east of CHAD and the CENTRAL AFRICAN REPUBLIC and west of NIGERIA. The capital is Yaounde.Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Guanabenz: An alpha-2 selective adrenergic agonist used as an antihypertensive agent.Toxoplasma: A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.Toxoplasmosis: The acquired form of infection by Toxoplasma gondii in animals and man.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Life Cycle Stages: The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.Folliculitis: Inflammation of follicles, primarily hair follicles.Skin Diseases, Vesiculobullous: Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)Eosinophilia: Abnormal increase of EOSINOPHILS in the blood, tissues or organs.Scalp DermatosesSwimming PoolsAchillea: A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Plant Components, Aerial: The above-ground plant without the roots.Ruscus: A plant genus of the family LILIACEAE. This should not be confused with Broom or Scotch Broom (CYTISUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM) or Brome (BROMUS).Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)

Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (1/370)

OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.  (+info)

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (2/370)

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs.  (+info)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (3/370)

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.  (+info)

Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. (4/370)

In persons with onchocerciasis, topical application of the anthelminthic diethylcarbamazine (DEC) induces clinical and histologic responses similar to acute papular onchodermatitis, including recruitment of eosinophils to the skin. To determine whether the eosinophil chemokine eotaxin is likely to be associated with eosinophil recruitment in onchodermatitis, DEC was applied to a 5-cm2 area on the skin of infected persons, and biopsies were taken from lesions 24 h later. Histologic analysis showed elevated dermal and epidermal eosinophils compared with tissue from an adjacent (untreated) site. Reverse transcription-polymerase chain reaction showed that eotaxin gene expression in DEC-treated skin was elevated 2- to 17-fold compared with control tissue. Eotaxin immunoreactivity was noted in mononuclear cells and eosinophils in the perivascular region of the dermis and in lymphatic and vascular endothelial cells. Together, these observations are consistent with a role for eotaxin in recruitment of eosinophils to the dermis in early stage onchocercal skin disease.  (+info)

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. (5/370)

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decreased locomotion, and bang sensitivity. Binding assays using glc(1) head membranes showed a marked decrease in the affinity for nodulisporic acid and ivermectin. A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was introduced into a recombinant DmGluClalpha, and RNA encoding wild-type and mutant subunits was injected into Xenopus oocytes. Nodulisporic acid directly activated wild-type and mutant DmGluClalpha channels. However, mutant channels were approximately 10-fold less sensitive to activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providing direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.  (+info)

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons. (6/370)

The gamma-aminobutyric acid (GABA) receptor is an important site of action of a variety of chemicals, including barbiturates, benzodiazepines, picrotoxin, bicuculline, general anesthetics, alcohols, and certain insecticides. Fipronil is the first phenylpyrazole insecticide introduced for pest control. It is effective against some insects that have become resistant to the existing insecticides. To elucidate the mechanism of fipronil interaction with the mammalian GABA system, whole-cell patch-clamp experiments were performed using rat dorsal root ganglion neurons in primary culture. Fipronil suppressed the GABA-induced whole-cell currents reversibly in both closed and activated states. The IC(50) values and Hill coefficients for fipronil block of the GABA(A) receptor were estimated to be 1.66 +/- 0.18 microM and 1.23 +/- 0.14 for the closed receptor, respectively, and 1.61 +/- 0.14 microM and 0.96 +/- 0.06 for the activated receptor, respectively. The association rate and dissociation rate constants of fipronil effect were estimated to be 673 +/- 220 M(-1) s(-1) and 0.018 +/- 0.0035 s(-1) for the closed GABA(A) receptor, respectively, and 6600 +/- 380 M(-1) s(-1) and 0.11 +/- 0.0054 s(-1) for the activated GABA(A) receptor, respectively. Thus, both the association and dissociation rate constants of fipronil for the activated GABA(A) receptor are approximately 10 times as large as those for the closed receptor. Experiments with coapplication of fipronil and picrotoxinin indicated that they did not compete for the same binding site to block the receptor. It is concluded that although fipronil binds to the GABA(A) receptor without activation, channel opening facilitates fipronil binding to and unbinding from the receptor.  (+info)

GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. (7/370)

1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects. 2. Expression of glc-3 cRNA in XENOPUS oocytes resulted in the formation of homo-oligomeric L-glutamate-gated chloride channels with robust and rapidly desensitizing currents, an EC(50) of 1.9+/-0.03 mM and a Hill coefficient of 1.5+/-0.1. GABA, glycine, histamine and NMDA all failed to activate the GLC-3 homo-oligomer at concentrations of 1 mM. The anthelminthic, ivermectin, directly and irreversibly activated the L-glutamate-gated channel with an EC(50) of 0.4+/-0.02 microM. 3. The GLC-3 channels were selective for chloride ions, as shown by the shift in the reversal potential for L-glutamate-gated currents after the reduction of external Cl(-) from 107.6 to 62.5 mM. 4. Picrotoxinin failed to inhibit L-glutamate agonist responses at concentrations up to 1 mM. The polycyclic dinitrile, 3,3-bis-trifluoromethyl-bicyclo[2,2,1]heptane-2,2-dicarbonitrile (BIDN), completely blocked L-glutamate-induced chloride currents recorded from oocytes expressing GLC-3 with an IC(50) of 0.2+/-0.07 microM. The phenylpyrazole insecticide, fipronil, reversibly inhibited L-glutamate-gated currents recorded from the GLC-3 receptor with an IC(50) of 11.5+/-0.11 microM. 5. In this study, we detail the unusual antagonist pharmacology of a new GluCl subunit from C. elegans. Unlike all other native and recombinant nematode GluCl reported to date, the GLC-3 receptor is insensitive to picrotoxinin, but is sensitive to two other channel blockers, BIDN and fipronil. Further study of this receptor may provide insights into the molecular basis of non-competitive antagonism by these compounds.  (+info)

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. (8/370)

The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several techniques including DNA fragmentation assay and in situ and cytofluorometry terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling methods and YOPRO-1 staining allowed us to demonstrate that potassium antimonyl tartrate, an Sb(III)-containing drug, was able to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum at low concentrations (10 microg/ml). This observation was in close correlation with the toxicity of Sb(III) species against axenic amastigotes (50% inhibitory concentration of 4.75 microg/ml). Despite some similarities to apoptosis, nuclease activation was not a consequence of caspase-1, caspase-3, calpain, cysteine protease, or proteasome activation. Altogether, our results demonstrate that the antileishmanial toxicity of Sb(III) antimonials is associated with parasite oligonucleosomal DNA fragmentation, indicative of the occurrence of late events in the overall process of apoptosis. The elucidation of the biochemical pathways leading to cell death could allow the isolation of new therapeutic targets.  (+info)

*Fexinidazole

... is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis ... Antimicrobial Agents and Chemotherapy. 54 (7): 2893-900. doi:10.1128/AAC.00332-10. PMC 2897277 . PMID 20439607. "Jump-Start on ...

*Penicillium cluniae

... is a fungus species of the genus of Penicillium which produces the antinematodal and antiparasitic agents ... Liesch, J. M.; Wichmann, C. F. (1990). "Novel antinematodal and antiparasitic agents from Penicillium charlesii. II. Structure ...

*Avermectin

Hotson, I. K. (1982). "The avermectins: A new family of antiparasitic agents". Journal of the South African Veterinary ... New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation". Antimicrobial Agents and Chemotherapy. 15 (3): ...

*Nitazoxanide

... [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Oral nitazoxanide is an available, approved antiparasitic agent (e.g., against cryptosporidium, giardia) with established ... a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. 2 (1): 43-9. doi:10.1586/14787210.2.1.43. PMID 15482170 ... Agents Chemother. 46 (7): 2116-23. doi:10.1128/aac.46.7.2116-2123.2002. PMC 127316 . PMID 12069963. Nitazoxanide (NTZ) is a ...

*Antiparasitic

Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ... Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. In 2005, a new antimalarial cost ... Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Broad-Spectrum antiparasitics, analogous to broad-spectrum antibiotics for bacteria, are antiparasitic drugs with efficacy in ...

*Antimicrobial Agents and Chemotherapy

It covers antimicrobial, antiviral, antifungal, and antiparasitic agents and chemotherapy. The editor-in-chief is Louis B. Rice ... Antimicrobial Agents and Chemotherapy is a peer-reviewed scientific journal published by the American Society for Microbiology ...

*Milbemycin

They are used in veterinary medicine as antiparasitic agents against worms, ticks and fleas. Like avermectins, milbemycins are ...

*Glutamate (neurotransmitter)

"Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin". ...

*Diarrhea

The broad-spectrum antiparasitic agent nitazoxanide has shown efficacy against many diarrhea-causing parasites. Other ... Anti-motility agents like loperamide are also effective at reducing the number of stools but not the duration of disease. These ... In most of these cases, osmotic diarrhea stops when the offending agent (e.g. milk, sorbitol) is stopped. Exudative diarrhea ... including agents used in chemotherapy; and certain drugs, like orlistat, which inhibits the absorption of fat. The two ...

*Ivermectin

... is a broad-spectrum antiparasitic agent, traditionally against parasitic worms and other multicellular parasites. It ... In 2013, this antiparasitic drug was demonstrated as a novel ligand of farnesoid X receptor (FXR), a therapeutic target for ... Vercruysse, edited by J.; Rew, R.S. (2002). Macrocyclic lactones in antiparasitic therapy. Oxon, UK: CABI Pub. p. Preface. ISBN ... Ivermectin is also being studied as a potential antiviral agent against the viruses chikungunya and yellow fever. A 2012 ...

*Onchocerciasis

A clinical trial of another antiparasitic agent, moxidectin (manufactured by Wyeth), began on July 1, 2009 (NCT00790998). A ... The key factor in elimination is mass administration of the antiparasitic drug ivermectin. The initial projection was that the ...

*Loa loa

Ivermectin has become the most common antiparasitic agent used worldwide but can lead to residual microfilarial load when given ...

*Tizoxanide

... , also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of ...

*Farnesyltransferase

FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in ... Agrawal AG, Somani RR (June 2009). "Farnesyltransferase inhibitor as anticancer agent". Mini Rev Med Chem. 9 (6): 638-52. doi: ... For this reason, several FTase inhibitors are undergoing testing as anti-cancer agents. ...

*Pyruvate synthase

Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Agents Chemother. 56 (8): 4103-11. doi:10.1128/AAC.00360-12. PMC 3421617 . PMID 22585229. Hoffman PS, Bruce AM, Olekhnovich I, ... Agents Chemother. 58 (8): 4703-12. doi:10.1128/AAC.03112-14. PMC 4136022 . PMID 24890599. Evans MC, Buchanan BB (1965). " ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed ...

*Peptide nucleic acid

... antigene and antisense therapeutic agent, anticancer agent, antiviral, antibacterial and antiparasitic agent, molecular tools ...

*3-dehydroquinate synthase

This makes it an ideal target for new antimicrobial agents, anti-parasitic agents, and herbicides. Other enzymes in the ...

*Host-directed therapeutics

... or antiparasitic agent. Several antiviral agents are host-directed therapeutics, and simply slow the virus progression rather ... host cell-directed agent". Antimicrob Agents Chemother. 53 (12): 5236. PMID 19805568. Hoang, KV; Borteh, HM; Rajaram, MV; Peine ... These immunomodulatory agents can also alter the epithelial cell environments, since they also have a role in innate signalling ... will likely only occur when it is co-delivered with a traditional agent that acts directly on the pathogen, such as an ...

*Michael Menaker

Menaker treated sparrows with Dry-Die, an anti-parasitic agent, to eliminate any possible effects of light transferring by ...

*Benzylpiperazine

It is often claimed that BZP was originally synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm ... Gastrointestinal agent Fipexide - Nootropic Imatinib - Anticancer agent Meclozine - Antihistamine Piberaline - Antidepressant ... Piribedil - Antiparkinsonian agent Trimetazidine - Antianginal Vesnarinone - Cardiotonic Designer drugs 4-Methyl-1- ...

*Infection

... antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...

*Benzoxazole

... s belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic ...

*Index of oncology articles

... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ... chemotherapeutic agent - chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker ...

*List of MeSH codes (D16)

... anti-infective agents, urinary MeSH D27.505.954.122.250 --- antiparasitic agents MeSH D27.505.954.122.250.075 --- anthelmintics ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...

*Aporphine

Anti-cancer agents. 5 (2): 173-182. doi:10.2174/1568011053174864. PMID 15777224. Oliver-Bever B., 1983, Medicinal plants in ... showed antiparasitic activity against Trypanosoma brucei. Investigation of possible mechanisms revealed that the compounds bind ... to DNA and act as intercalating agents, besides inhibiting topoisomerase activity. (R)-Aporphine is a dopamine receptor D1 ...

*Seymour Hutner

Hutner was one of the first to appreciate the importance of organic complexing agents in trace metal nutrition of cells . This ... Under the leadership of Hutner's student, Cyrus Bacchi, the former led to development of the antiparasitic drug eflornithine ( ... alpha-difluoromethylornithine), widely used today against African sleeping sickness (trypanosomiasis). Work on antiparasitic ...
TY - CHAP. T1 - Antiparasitic Agents. AU - Leder, Karin. AU - McGuinness, Sarah L. AU - Weller, Peter F. PY - 2019. Y1 - 2019. N2 - A number of effective antiprotozoal and anthelmintic drugs are currently available. Antiparasitic agents are important both for therapy of infected individual patients and for control of parasitic infections at the community level. Large-scale chemotherapy is reducing transmission, morbidity, and mortality of certain infections, including lymphatic filariasis, onchocerciasis, schistosomiasis, and infections with intestinal nematodes. However, the lack of financial incentives to develop new agents is a major limitation to the future of antiparasitic chemotherapy. Emerging resistance among parasites, lack of effective antiparasitic vaccines, and the enormous burden of disease worldwide also pose challenges to the effective management of parasitic infections. This chapter focuses on the mechanisms of action, pharmacology, clinical utility, and adverse effects of common ...
The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R1 when taken individually is H or OH; R and R1 when taken together represent a double bond; R2 is an alpha-branched C3 -C8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C3 -C8 cycloalkyl, C5 -C8 cycloalkenyl or C5 -C8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C1 -C4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C1 -C4 alkyl groups or halo atoms; R3 is hydrogen or methyl; R4 is H or 4-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R2 is alkyl it is not isopropyl or sec-butyl; when R4 is H, each of R and R1 is H, and R2 is not methyl or ethyl; and when R4 is H, R is H, R1 is OH, and R2 is not 2-buten-2-yl, 2-penten-2-yl or 4-methyl-2-penten-2-yl. The compounds are broad spectrum antiparasitic agents having utility as
The U.S. small ruminant industry needs new antiparasitic drugs, and the sustainable use of these drugs will help maintain their effectiveness for as long as possible.
Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a terrible toll of human life, health and productivity, especially in tropical and subtropical regions, and are also highly significant in animal health worldwide. Antiparasitic drugs are the mainstays of control of most of these diseases, but in many cases current therapies are inadequate and in some the situation is deteriorating because of drug resistance. Microtubules, as essential components of almost all eukaryotic cells, are proven drug targets in many helminth diseases and show promise as targets for the development of new antiprotozoal drugs. Objective: This article reviews the chemistry of the microtubule inhibitors in current use and under investigation as antiparasitic agents, their activities against the major parasites and their mechanisms of action. New directions in both inhibitor chemistry and biological evaluation are discussed. Conclusions: The most promising immediate avenues for discovery and
Six medical students inhabiting a centuries-old, rat-infested house in Lübeck, in northern Germany, were suffering from itching papules and seropapules. Prior to these patients visit to our institute, their conditions had been diagnosed as pediculosis, scabies, or pulicosis and treated unsuccessfully with the antiparasitic agent lindane (0.3%). The final diagnosis, tropical rat mite dermatitis, was based on the identification of the arthropod Ornithonyssus bacoti, which has an unsegmented body with eight legs. No treatment was recommended, and the dermatitis disappeared within 2 weeks. Measures taken to prevent reinfestation included extermination of the rats and treatment of the rooms of the house with the acaricide benzyl benzoate. Because the mite O. bacoti spends a relatively short time on a host and penetrates the skin for feeding only, the application of an antiparasitic agent is not necessary. If indicated, treatment should be symptomatic.. ...
Abstract. To identify known drugs with previously unrecognized anticancer activity, we compiled and screened a library of such compounds to identify agents cyt
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Press Release issued Aug 2, 2017: The Animal Parasiticides Market is growing tremendously due to the increasing trend of pet adoption amongst people in developed as well as developing economies. However, the cost associated with animal parasiticides products, heavy expenditure on R & D for new product development and stringent regulatory policies related to the approval of animal parasiticides are factors that are adversely affecting the growth of the market.
Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well. Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. Nitazoxanide is an effective first-line treatment for infection by Blastocystis ...
[110 Pages Report] Check for Discount on Global Animal Parasiticides Market Professional Survey Report 2017 report by QYResearch Group. This report studies Animal Parasiticides in Global market, especially in...
Parasitic infections afflict more than half of the worlds population and impose a substantial health burden, particularly in underdeveloped nations, where they are most prevalent. The reach of some parasitic diseases, including malaria, has expanded over the past few decades as a result of factors such as deforestation, population shifts, global warming, and other climatic events. Despite major efforts at vaccine development and vector control, chemotherapy remains the single most effective means of controlling parasitic infections. Efforts to combat the spread of some diseases are hindered by the development and spread of drug resistance, the limited introduction of new antiparasitic agents, and the proliferation of counterfeit medications. However, there are good reasons to be optimistic. Ambitious global initiatives aimed at controlling or eliminating threats such as AIDS, tuberculosis, and malaria have demonstrated some early successes. Recognition of the substantial burden imposed by the ...
Compare prices and find information about Antiparasitics prescription drugs. Antiparasitics are used to treat lice, parasitic infections, and...
Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the prevention and cure of parasitic infections.
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Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic burdens. The rise of drug-resistant parasites has created an urgent need to study their biology in hopes of uncovering new potential drug targets. It has been established that disrupting gene expression by interfering with lysine acetylation is detrimental to survival of apicomplexan (Toxoplasma gondii and Plasmodium spp.) and kinetoplastid (Leishmania spp. and Trypanosoma spp.) parasites. As "readers" of lysine acetylation, bromodomain proteins have emerged as key gene expression regulators and a promising new class of drug target. Here we review recent studies that demonstrate the essential roles played by bromodomain-containing proteins in parasite viability, invasion, and stage switching and present work showing the efficacy of bromodomain inhibitors as novel antiparasitic agents. In addition, we performed a phylogenetic analysis of ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Alcohol use disorders (AUDs) ranks third in the list of preventable causes of morbidity and mortality in United States having a major national impact affecting over 18 million people and causing over 100,000 deaths annually. The prevalence of AUDs, in combination with limited clinical efficacy of currently approved FDA drugs in the treatment of this disorder signifies the importance for development of novel therapeutic agents. Alcohol is known to modulate a multitude of receptors in the brain to induce its cellular and behavioral effects. Recent electrophysiological findings from our laboratory, coupled with genomic studies, have suggested that the ionotropic receptor, P2X4 receptor (P2X4R) is a critical target that is modulated by ethanol. P2X4R activity has been demonstrated to be inhibited by ethanol at intoxicating and anesthetic concentrations. Recent evidence from our laboratory using electrophysiological strategies has shown that the FDA approved antiparasitic agent, ivermectin (IVM) ...
Zimecterin® Paste kills important internal parasites, including bots and the arterial stages of S. Vulgaris, with a single dose. Zimecterin® Paste is potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. Zimecterin® Paste kills large strongyles, small stro
Raw, unfiltered organic apple cider vinegar (ACV) is full of vitamins, mineral and substances such as carotenoids, flavonoids, isoflavones and protease inhibitors.. These nutrients feed and modulate the immune system and improve skin health. For example, beta-carotene promotes skin regeneration while fiber improves digestive health to flush out toxins.. On the other hand, potassium balances pH balance of the skin to reduce inflammation and irritation.. Vinegar also works as an antibacterial, antifungal and antiparasitic agent to fight any infection causing the skin condition.. Heres how you can use this multipurpose food to heal your skin.. Click NEXT Button below to continue…. ...
Includes information on infection detection and prevention and control, diagnostic technologies, bacteriology, antibacterial, antiviral, antifungal, and antiparasitic agents and susceptibility test methods, virology, mycology, and parasitology.
IMPORTANT: There are marked regional and national variations in both parasite fauna and the availability/claims/doses/withhold periods of parasiticides around the world. ALWAYS check the specific product information for the product you are administering and ensure that you comply with local rules. Examples given in this article may be correct for one country but rules may differ in other regions. ...
Petwise is Australias leading wholesaler of livestock parasiticides. Browse our range of cattle tick treatment, sheep tick treatment and much more, and keep your store well-stocked with the essentials. We offer competitive prices and ship nationwide.
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Functionalized quinolines are an important group of heterocyclic molecules with diverse, different, and interesting biological and pharmacological activities. Traditionally, several methods have been developed for the construction of this N-heterocyclic ring, but nowadays the functionalization of the quinoli 2019 Focus and Perspective articles
Six nonsmoking, adult, male volunteers participated in the study. Each subject was judged to be in good health on the basis of a physical examination, clinical
Formalin is a liquid formulation of 37% formaldehyde gas dissolved in water. Two brands of formalin, Formalin-F (Natchez Animal Supply, Natchez, Miss.) and Paracide-F (Argent Chemical Laboratories, Redmond, Wash.), have been approved by FDA as parasiticides for use on fish. Formalin is effective against many external parasites, including protozoans and monogenetic trematodes. It is not generally considered the best treatment for external fungal or bacterial infections. Formalin can be delivered in a short-term bath at a concentration of 250 mg/l - or 150 mg/l if water temperature is greater than 70°F (21°C) - for no more than 60 minutes. It can be delivered as an indefinite bath at a concentration of 15 to 25 mg/l. Formalin is an excellent parasiticide for use in tanks and aquaria, but its use in ponds is discouraged because it chemically removes oxygen from the water and can contribute to catastrophic oxygen depletion under pond conditions. This is avoided in tanks and aquaria by always ...
Contributing to the complicated nature of pet parasite control, regulation and availability of these products is not uniform. Some products are considered insecticides and, in the United States, are regulated by the Environmental Protection Agency, while others count as medications and fall under the jurisdiction of the U.S. Food and Drug Administration. Some flea-and-tick control methods are available to pet owners over the counter from pet and big-box stores. Others are available only from veterinary clinics or from pharmacies presented with a prescription from a veterinarian who has examined the pet. ...
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Protein Phosphorylation in Parasites Novel Targets for Antiparasitic Intervention by Christian Doerig http://i.imgur.com/3NZhmn5.jpg Pages: 456 Publisher: -- Edition: 1st., 2013
Veterinary Formula Clinical Care Antiparasitic and Antiseborrheic Medicated Shampoo is effective in treating Seborrhea and parasitic and fungal infections.
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View list of generic drugs that are Therapeutically classified under Antiparasitic - antitapeworm drugs. Find related prescribing information and price details for each drug listed under it.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Dr Butters works in the Glycobiology Institute which is headed by Professor Raymond Dwek. His expertise in glycoprotein biology led to him being contacted by Dr Rossignol.. Dr Rossignol approached our group to see if we could help him find a mechanism of action for thiazolides. If we understand the mechanism better, then well be able to improve drug design, explains Dr Butters.. His group works with small molecules that interfere with the cellular processes responsible for glycoprotein production. He is trying to develop these into drugs against the hepatitis C virus which also uses a viral envelope glycoprotein.. If more can be uncovered about how thiazolides work, this may also open up the possibility of using them in combination with compounds Dr Butters own lab is developing.. We have a known mechanism of action for our compounds, and our initial experiments suggest that the drug works in a slightly different way. Both interfere with glycoprotein maturation of viral envelope proteins, ...
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Estimates indicate that across tropical and sub-tropical regions of the World more than 12 million people suffer from various forms of Leishmaniasis, infections caused by protozoan parasites belonging to the genus Leishmania. With no prospect of a vaccine chemotherapy is of major importance. However, current treatments are unsatisfactory & the development of new drugs is a priority. Previous drug screening programmes carried out at SBCS have identified several, potent anti-parasitic nitro- & quinone-based compounds that show little/no cytotoxicity to mammalian cells. These compounds invariably function as prodrugs & following activation are postulated to mediate their mode of action by promoting DNA damage.. ...
Squash. Eating squash have been directly linked to anti-parasitic and anti-fungal activity in the body. The compounds in squash help to protect us from a wide variety of diseases, including intestinal parasites, according to sources. ...
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Ever wonder what the best bodyweight workout is? This post goes over everything you need to have a successful bodyweight workout.
This program doesnt use traditional interval training. Instead, you will perform one of the following bodyweight circuits after the strength training portion of the workout. This will be your bodyweight interval circuit conditioning ...
Bodyweight Training: Bodyweight exercises have many advantages over traditional exercises like the clichéd dumbbell curl or shiny, chrome machines.
If you are pressed for time, a bodyweight circuit workout is a great way to get a quick one in. Circuits are typically performed at a high intensity with...
Whats you guys opinion on bodyweight exercise routines like Matt Fureys Combat Conditioning? Alot of people report that these types of
Add strength, muscle, and size to your triceps with this at-home, no-equipment bodyweight skullcrusher variation that emphasizes eccentric focus.
If youre just learning about bodyweight workouts were sure you have a lot of questions about what you need to be prepared for and how to begin. We want to see
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... , increasing the sets and reps will increase your strength and increase the amount of muscle that you can put on in each training session.
Our picks for the best bodyweight workouts are made up of super-effective minimalist moves. And they each take about 20 minutes or less.
My gym just closed down and i will be forced to do bodyweigth excercises exclusively. I read some post about these excercises on the forum, and now i am...
Problem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of the efficacy of ivermectin pour-on administration against natural Heterakis gallinarum infection in native poultry and also determination the prevalence rate of this parasite in Tabriz area. Approach:In the present study, 120 native poultry were investigated by Egg Per Gram of feces (EPG) feces test. Willis method was applied for feces test and Mack-master slide method was used for counting nematode eggs. After confirming the infection with worms, Ivermectin (0.5 mg kg−1) pour-on was administrated to infected birds. Fecal examination was repeated in 1, 7, 21 and 28 days post treatment. Results: Results showed
BioAssay record AID 626318 submitted by ChEMBL: Antiparasitic activity against amastigotes of Leishmania donovani MHOM/ET/67/L82 infected in rat L6 cells after 72 hrs by by Alamar blue assay.
BioAssay record AID 376631 submitted by ChEMBL: Antiparasitic activity against Toxoplasma gondii in human foreskin fibroblast by beta-galactosidase assay.
NOSB Deliberates. 10:38 a.m. ET: The NOSB reapproves continued use of several other livestock materials, including oxytocin, magnesium sulfate, magnesium hydroxide, iodine, hydrogen peroxide, glycerin, glucose, flunixin, electrolytes, chlorhexidine, and butorphanol.. 10:35 a.m. ET: The NOSB reapproves the continued use of the parasiticide moxidectin. (Cornucopias analysis of the parasiticide issues begins at page 157 here: http://bit.ly/1LxCzWh). 10:33 a.m. ET: More discussion occurred over the parasiticide ivermectin. Members talked about its impact on the environment, effectiveness, and need. Several members noted their reluctance to remove a material used by livestock farmers. When voting took place, 6 supported removal, with only 4 opposing and 4 abstaining. This keeps ivermectin on the National List but again, this would not have been the case had the previous Sunset rules been in place.. 10:29 a.m. ET: The NOSB unanimously reapproves the use of the parasiticide fenbendazole.. 10:01 a.m. ...
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Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discovery of innovative drug candidates. A first series of inhibitors has been prepared on the basis of known substrate specificity and the predicted catalytic mechanism of the enzyme. In this Letter we present the first inhibitors of TbMCA2 with low micromolar enzymatic and antiparasitic activity in vitro combined with low cytotoxicity.. ...
Dechra LimePlus Dip is a concentrated sulfurated lime solution for non-specific dermatoses where sulfurated lime is effective. Antifungal - Antiparasitic. Can be used on dogs, cats, puppies, kittens and horses.
Buy Aralen is used for treating and suppressing acute attacks of certain strains of malaria and a certain type of parasitic infection (extraintestinal amebiasis).. Aralen (Chloroquine Phosphate 250/500mg) $0.46 pill - Antiparasitic @ Achat Medicament En Suisse En ligne - Sans Ordonnance. Acheter Medicament Sans Ordonnance en ligne en Suisse, en France, en Belgique.
6. Garlic has anti-parasitic and anti-bacterial properties: Garlic has been known throughout the ages to be an effective anti-bacterial and anti-parasitic agent. Garlic extracts or small amounts of garlic in your diet can help you build up immunity and also kill infections within your system effectively. It is also known to be very effective against tapeworm infestations within the gut. ...
A dose-dependent trypanocidal activity of propolis extract was observed in vitro. All trypomastigotes were killed 1 h after incubation with 10 μg mL−1 of the extract. In vivo, the concentrations of 100, 200, 300 and 400 mg kg−1 administered orally for 10 consecutive days showed no curative effect, and the rats died from the disease. However, rats treated with the two highest concentrations of propolis extract showed higher longevity than the other groups ...
Merial Pet Vaccination reviews: Merial Pet Vaccination Review. Our maltese chihuahua mix became deathly ill within 2 hours of receiving the Merial vaccine.
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Davis MI, Patrick SL, Blanding WM, Dwivedi V, Suryadi J, Golden JE, Coussens NP, Lee OW, Shen M, Boxer MB, et al. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrobial Agents and Chemotherapy. 2016 ;60:6023-6033. ...
Antiparasitic drugs have been used successfully to control parasitic diseases in animals for many years, as they are safe, cheap and effective against a broad spectrum of parasites. One drawback of this success appears to be the emergence of drug resistance in many target parasites. Moreover, issues of residues in the food chain and environment have arisen, which threaten their sustained use. Control methods in which vaccines would have a central role provide attractive alternatives. However, while attenuated parasite vaccines have been successful, sub-unit vaccines are still rare. The advent of new techniques in molecular biology allows the elucidation of entire parasite genomes and the identification of individual genes. It is envisaged that a further understanding of parasite genes and the role of their products in parasite biology may lead to the identification of useful antigens, which could then be produced in recombinant systems. However, for this aim to be realised, continued investment ...
Vermanth 400 MG Tablet is an antiparasitic drug used in the prevention and treatment of parasitic infections caused by tapeworms, pinworms and hookworms. Buy Vermanth 400 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Download Practo app & get your medicines home delivered.
Allin 400 MG Tablet is an antiparasitic drug used in the prevention and treatment of parasitic infections caused by tapeworms, pinworms and hookworms. Buy Allin 400 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Download Practo app & get your medicines home delivered.
... Responsible for oversight of programme, organizing sessions, themes and workshops, developing timetable for each session and inviting speakers. Name Andy Fenton (coinfection) Andy Thompson (protozoa population genomics) Carlos Lanusse (Antiparasitic Drugs Pharmacology) Damer Blake (protozoa and vaccine development) Daniel Masiga, ICIPE, Kenya Diana Williams, Cochair Domenico Otranto (filarial nematodes plus EVPC) Title Dr. Andy Fenton BSc MSc PhD Professor RC Andrew Thompson Professor Carlos Lanusse MedVet DrCsVet PhD DipECVPT Dr. Damer Blake BSc MSc PhD PGCVetEd FHEA Dr. Daniel Masiga BSc Msc PhD (Molecular Parasitology) Professor Diana JL Williams Professor Domenico Otranto BVetMed PhD DipEVPC FRES Affiliations Institute of Integrative Biology, University of Liverpool School of Veterinary and Health Sciences, Murdoch University, Australia Director, Veterinary Research Center, National Council of Scientific and Technical Research, Argentina Senior Lecturer in Molecular ...
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parasiticidal definition: with the capacity of destroying parasites, specifically effective at expelling or destroying parasitic worms.; related to or for the nature of a parasiticide.; effective at expelling…
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Rabbits housed outdoors are prone to fleas, ticks and mites. Prevention and treatment of these detrimental pests is important to the health and well-being of your rabbits.
Adding prescription medicines as a supplement to dog food can be beneficial. However, with the increasing number of available medicines nowadays, its best to know which are safe for your dog, or not.. Some drugs can prevent diseases while others can cure dog ailments. Thus, you should give the right medicine according to the signs and symptoms present.. Heres a list of medications that may be prescribed for your dog at some point in their life:. Pain Relievers - If your dog is in pain, analgesics are an option. Choosing non-steroidal anti-inflammatory drugs (NSAIDs) is even better to decrease your dogs inflammation. As a result, they can feel a whole lot better.. Sedatives - When your dog is anxious, they may harm themselves with unusual behaviors. Sedatives and other behavior-modifying medicines for dogs can calm them and reduce their strange behavior.. Antiparasitics - This type of medication is one of the most vital medicines your dog needs. It can suppress or kill ticks, fleas, ...
For the treatment and control of internal and external parasites of beef and non-lactating dairy cattle, sheep and pigs. One low-volume dose of Noromectin Multi Injection controls internal and external parasites that impair the health and productivity.
Take each dose with a full glass of water or with meal. The intake of the drug must be different that depends on the type of infection. For treating of malaria, in adults the dosage is 500 mg at the same day of each week. In children the base dose is 5 mg per kg of body weight, 10 mg base/kg must be divided in two doses with break on six hours. For treating of acute attack, in adults the recommended dose is 1 g followed by an additional 500 mg after six to eight hours and a one dose of 500 mg on each of two cumulative days. Take Aralen exactly as directed by your doctor ...
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Problem stomach - I have amibiasis problem stomach problem from many yr. What should I do to recover from that. I get temp relief from tab ciplox tz. Pl reply permanent? Wrong treatment. Ciplox (ciprofloxacin) is an antibiotic used for treatment of bacterial infection. Amoebiasis is caused by e. Histolytica, a protozoan parasite which needs to be treated with an anti-parasitic medication or metronidazole. Would advise confirming diagnosis one year out.
My laboratory group is interested in the inflammatory response in immune cells called macrophages. The inflammatory responses stimulated by macrophages are important to resolve infections but also result in many chronic conditions such as Rheumatoid Arthritis and Crohns Disease. Our research objectives are two-fold: to characterize the interaction of human macrophages with microbes and to find new therapies that will regulate the inflammatory response.. I am a member of a group of researchers at MTSU that comprise the Tennessee Center for Botanical Medicine. We are located in the departments of Biology, Chemistry and Agriscience. Our faculty work together to isolate and characterize novel botanicals and modify existing natural compounds that have anti-cancer, anti-viral, anti-parasitic, as well as anti-inflammatory activity.. Grants. ...
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hello, wanting to know how best to log bodyweight sets. Specifically DIPS but also any other bodyweight exercise. Do I list my weight as the weight lifted or do I leave that at zero? Thanks Randy
... , there is no question about it that anyone who can bench press twice their own bodyweight is certainly very strong. He will probably be very aware of the fact that in many different man-circles this is a gold standard that is equivalent to running a mile in 4 minutes.
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I think that for your stated goals (leaning out, getting more "in shape" boosting work capacity, that you have a good solid program. For a million other ideas for variations sake, you could go over to crossfit.com, as a lot of their workouts contain bodyweight only, with lots of burpees and sprints thrown into the mix as well ...
So you can run far and lift heavy, but can you do basic bodyweight movements like pull ups, handstands, and pistols? Here are 9 posts to help you get stronger with zero equipment.
Were back today with a sample workout from the Bodyweight Cardio 500 program. Remember - what makes this workout - and the entire program - unique
In a bind for time? Erin Bailey is leading us through an outdoor, bodyweight circuit focusing on the booty in this video. We headed to the Esplanade, but you can do it anywhere-all you need is a bench!
I started doing the 666 bodyweight home workout and I would highly recommend it to anyone who doesnt have access to a gym: the progressions are awesome and -we...
Bodyweight Burn system download in PDF format. Find below a free preview for Adam Steers BodyWeightburn website powered by Scribd. Using this 21-minute method,
Feeling daunted by human flags, toes-to-bar, and strict muscle-ups? Youre not alone. Al Kavadlo has seen it all and can help you troubleshoot your bodyweight work.
Suns out, buns out! Try this quick home workout to target your glutes and core with some of my favorite bodyweight exercises.  
The other half of the Nobel Prize was awarded to William C. Campbell, a microbiologist at Drew University in Madison, New Jersey, and Satoshi Ōmura, a microbiologist at Kitasato University in Japan. Both Ōmura and Campbell discovered avermectins, a class of compounds that can kill parasitic roundworms that cause crippling diseases, such as lymphatic filariasis, otherwise known as elephantiasis, and onchocerciasis or river blindness.. In the mid-1970s, Ōmura used the techniques of Selman Waksman to identify anti-parasitic compounds from soil bacteria known as Streptomyces and found success in a soil sample from a nearby golf course. (The same laborious technique was also used by two female scientists in New York to identify one of the worlds first antifungal drugs.) Campbell identified one such component of Ōmuras cultures that had unique anti-parasitic activity and refined its derivative, ivermectin. Today, the drug has not only reduced the crippling morbidity of these two dreadful ...
Generic Vermox (Mebendazole) is used for treatment of certain worm infections (eg, pinworm, roundworm, whipworm, hookworm). Mebendazole is an anthelmintic agent. It works by killing sensitive worms and causing them to be expelled from the body.. Generic Vermox (Mebendazole 100mg) $ 1.04 pill - Antiparasitic @ KupTania.
A man with Escherichia coli meningitis and bacteremia, while on dexamethasone, developed Strongyloides hyperinfection syndrome and died despite salvage therapy with subcutaneous ivermectin. We report the first documented total and free levels of subcutaneous ivermectin used for therapy.
... REVOLUTION* (SELAMECTIN) Topical Parasiticide For Dogs, Cats, Puppies and Kittens The REVOLUTION* range of topical parasiticides contains SELAMECTIN a novel semi‐synthetic compound of the macrocyclic lactone class, in a colourless to pale yellow, ready to use solution. It is available in colour coded, single dose tubes for topical (dermal) treatment of dogs and cats beginning at six weeks of age. The content of each tube is formulated to provide a minimum of 6mg Selamectin/kg body weight. INDICATIONS: For the treatment, control and prevention of flea (Ctenocephalides spp.) infestations, control of flea allergy dermatitis, prevention of heartworm disease caused by Dirofilaria immitis and the treatment and control of ear mites (Otodectes cynotis) in dogs and cats. For the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs, and intestinal hookworms (Ancylostoma tubaeforme) and roundworms (Toxocara cati) in cats. EFFICACY: Adult fleas are killed ...
Head lice infestation, also known as pediculosis capitis and nits, is the infection of the head hair and scalp by the head louse (Pediculus humanus capitis). Itching from lice bites is common. During a persons first infection, the itch may not develop for up to six weeks. If a person is infected again, symptoms may begin much more quickly. The itch may cause problems with sleeping. Generally, however, it is not a serious condition. While head lice appear to spread some other diseases in Africa, they do not appear to do so in Europe or North America. Head lice are spread by direct contact with the hair of someone who is infected. The cause of head lice infestations are not related to cleanliness. Other animals, such as cats and dogs, do not play a role in transmission. Head lice feed only on human blood and are only able to survive on human head hair. When adults, they are about 2 to 3 mm long. When not attached to a human, they are unable to live beyond three days. Humans can also become ...
Public Health Recommendations for the Prevention and Control of Head Lice Infestation in Schools and Child Care Settings A Guide for School and Child Care Setting Administrators For further information call or visit us on the World Wide Web Acute Disease Service Oklahoma State Department of Health Phone (405) 271-4060 http://ads.health.ok.gov FOREWARD The Head Lice Control Manual is intended to: 1) provide basic information about head lice infestation, treatment, and prevention, 2) communicate the recommendations of the Oklahoma State Department of Health regarding head lice control, and 3) provide a foundation for school and child care setting head lice policies. This manual has been prepared by a joint working group consisting of: epidemiologists of the Communicable Disease Division, nurses and nurse practitioners of the Nursing Service and the Local Health Service, nurses of the School Health Program of the Maternal and Child Health Service, all of the Oklahoma State Department of Health. ...
The biggest problem in controlling head lice infestations is convincing parents, teachers and even school administrators that head lice infestations are not caused by filthy conditions. For example, one school principal denied the existence of a head lice infestation in his school, even though the wife of a University of Florida graduate student, who was a teacher at that school, confirmed that such the problem existed. The principals denial of the problem, and his refusal for our staff to cooperate with his school nurse, prevented us from controlling the infestation and preventing its recurrence. In addition, lack of knowledge of the biology and ecology of the head louse resulted in the school administrator calling in the school district-contracted, pest control company and demanding that its personnel spray the rugs for control of the head louse infestation. Since head lice occur only on the bodies of children, the pest control company was powerless to do anything to control the infestation. ...
Ivermectin is one of the most widely used drugs in global health. Billions of doses have been distributed in the last 30 years by mass drug administration for onchocerciasis and lymphatic filariasis.. During mass drug administration campaigns with ivermectin, children weighing less than 15 kilograms are excluded from treatment as the safety of ivermectin in this group has not been established. Both scabies and malaria control communities are evaluating the capacity of ivermectin mass drug administration for control and elimination. Scabies can be effectively treated with oral ivermectin, but contraindication of use in children less than 15 kilograms requires the use of various topical creams. These topical creams may be less effective than oral ivermectin due to compliance and improper application, which can impede both individual treatment and mass drug administration efforts.. Ivermectin mass drug administration for malaria parasite transmission suppression aims to deliver mosquito-lethal ...

Eosinophilic Pustular Folliculitis | SpringerLinkEosinophilic Pustular Folliculitis | SpringerLink

Antiparasitic Agents. In: Wolverton SE editor. Comprehensive dermatologic drug therapy. Philadelphia (PA): W.B. Saunders, 2001 ... Systemic antifungal agents. In: Wolverton SE, editor. Comprehensive drug therapy. Philadelphia (PA): W.B. Saunders, 2001: 55-84 ...
more infohttps://link.springer.com/article/10.2165/00128071-200405030-00007

Achillea fragrantissima | GreenMedInfo | Substance | Natural MedicineAchillea fragrantissima | GreenMedInfo | Substance | Natural Medicine

Pharmacological Actions : Antiparasitic Agents. Additional Keywords : Natural Substance/Drug Synergy. [+] Achillea ... Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix ... metalloproteinase-9 (MMP-9) inhibitor, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha ...
more infohttp://www.greenmedinfo.com/substance/achillea-fragrantissima

Actinomycosis in Ophthalmology Medication: Antibiotics, Antiparasitic agentsActinomycosis in Ophthalmology Medication: Antibiotics, Antiparasitic agents

Antiparasitic agents. Class Summary. Parasite biochemical pathways are sufficiently different from the human host to allow ...
more infohttps://emedicine.medscape.com/article/1203061-medication

Antiparasitic agents - Patent # 5089480 - PatentGeniusAntiparasitic agents - Patent # 5089480 - PatentGenius

2-penten-2-yl or 4-methyl-2-penten-2-yl.The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ... The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. They are ... This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but ... The compounds of the invention are highly active antiparasitic agents having particular utility as anthelmintics, ...
more infohttp://www.patentgenius.com/patent/5089480.html

Patent US5451511 - Process for the preparation of antiparasitic agents - Google PatentsPatent US5451511 - Process for the preparation of antiparasitic agents - Google Patents

The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and ... Antiparasitic agents. EP0001689A1 *. Sep 29, 1978. May 2, 1979. Merck & Co., Inc.. Selective hydrogenation products of C-076 ... The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. They are ... This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but ...
more infohttp://www.google.com/patents/US5451511?dq=4,821,260

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.  - PubMed - NCBIVinyl sulfones as antiparasitic agents and a structural basis for drug design. - PubMed - NCBI

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.. Kerr ID1, Lee JH, Farady CJ, Marion R, Rickert ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19620707

Antiparasitic Agents Market Growth Opportunities by Regions, Type & Application; Trend Forecast to 2021 | MedgadgetAntiparasitic Agents Market Growth Opportunities by Regions, Type & Application; Trend Forecast to 2021 | Medgadget

The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic ... US Antiparasitic Agents Production, Revenue (Value) by Region (20Antiparasitic Agents-2016). *US Antiparasitic Agents Supply ( ... US Antiparasitic Agents Production, Revenue (Value), Price Trend by Type. *US Antiparasitic Agents Market Analysis by ... The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic ...
more infohttps://www.medgadget.com/2017/03/antiparasitic-agents-market-growth-opportunities-by-regions-type-application-trend-forecast-to-2021.html

Antiparasitic Agents<...Antiparasitic Agents<...

Antiparasitic Agents. Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review ... Antiparasitic Agents. Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review ... Antiparasitic Agents. / Leder, Karin; McGuinness, Sarah L; Weller, Peter F.. Manual of Clinical Microbiology. ed. / Karen C. ... Leder, K., McGuinness, S. L., & Weller, P. F. (2019). Antiparasitic Agents. In K. C. Carroll, M. A. Pfaller, M. L. Landry, A. J ...
more infohttps://research.monash.edu/en/publications/antiparasitic-agents-3

Studies of toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the...Studies of toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the...

... suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials. ... and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents ... and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. ... antibacterial agents, biological-activity, crystal-structure, escherichia-coli, molecular-basis, enoyl acyl carrier protein ...
more infohttps://strathprints.strath.ac.uk/31730/

ANTIPARASITIC AGENTS - Patent applicationANTIPARASITIC AGENTS - Patent application

... further antiparasitic agents. [0160]Examples of antiparasitic agents that may be used in combination with the compounds of ... Patent application title: ANTIPARASITIC AGENTS. Inventors: Stephen Paul Gibson Christelle Lauret Agents: PHARMACIA & UPJOHN ... Patent application title: ANTIPARASITIC AGENTS. Inventors: Stephen Paul Gibson (Sandwich, GB) Christelle Lauret (Sandwich, GB) ... 4,639,771 and DE-19520936); [0168]derivatives and analogues of the general class of dioxomorpholine antiparasitic agents as ...
more infohttp://www.patentsencyclopedia.com/app/20080200540

Antiparasitic Agents - Sinoway Industrial Co., Ltd.Antiparasitic Agents - Sinoway Industrial Co., Ltd.

The antiparasitic drugs can be divided into antiprotozoal and antihelminthic drugs. In general, commonly used are highly ...
more infohttps://www.china-sinoway.com/health-solutions/antiparasitic-agents.html

Antimicrobial Agents -Antiparasitics Flashcards by Michael McHugh | BrainscapeAntimicrobial Agents -Antiparasitics Flashcards by Michael McHugh | Brainscape

Study Antimicrobial Agents -Antiparasitics flashcards from Michael McHugh ... Antimicrobial Agents -Antiparasitics Flashcards Preview 4 Pharm Self , Antimicrobial Agents -Antiparasitics , Flashcards ... With the antifilarial agents, what are the inflammatory response and side effects due to? ...
more infohttps://www.brainscape.com/flashcards/antimicrobial-agents-antiparasitics-3057513/packs/4874110

WHO HQ Library catalog ›

    Results of search for su:{Antiparasitic agents.}WHO HQ Library catalog › Results of search for 'su:{Antiparasitic agents.}'

Book; Format: print Publisher: Geneva : World Health Organization, 1995Other title: Drugs used in parasitic diseases.Title translated: Fiches modèles OMS d information à l usage des prescripteurs : médicaments utilisés en parasitologie; Modelo OMS de informaciòn sobre prescripción de medicamentos : medicamentos utilizados en las enfermedades parasitarias.Online access: Full text now in IRIS , Full text now in IRIS Availability: Items available for loan: WHO HQ [Call number: QV 253 95WH] (2). Withdrawn (1). ...
more infohttps://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BAntiparasitic%20agents.%7D

Proceedings | Free Full-Text | Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and...Proceedings | Free Full-Text | Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and...

Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents† Rodolfo Lavilla ... Lavilla, R. Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents. ... Lavilla R. Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents. ... "Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents." Proceedings 1 ...
more infohttp://www.mdpi.com/2504-3900/1/6/666

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells |...The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells |...

... we compiled and screened a library of such compounds to identify agents cyt ... but has not been previously tested as an anticancer agent. As part of the development of this agent as an antiparasitic agent, ... The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells ... As an antiparasitic agent, ivermectin activates chloride channels in nematodes, causing an influx of chloride ions into the ...
more infohttps://ashpublications.org/blood/article/116/18/3593/27970/The-antiparasitic-agent-ivermectin-induces

China Antiparasitics and antispirochete agents Catalog--the Antiparasitics and antispirochete agents Catalog of China...China Antiparasitics and antispirochete agents Catalog--the Antiparasitics and antispirochete agents Catalog of China...

... agents Catalog is online Antiparasitics and antispirochete agents database of China Antiparasitics and antispirochete agents ... Featured China Antiparasitics and antispirochete agents Products. * Diminazene 536-71-0 ... ,,,. SHANGHAI TRUSTIN CHEMICAL CO., ... and China Antiparasitics and antispirochete agents Suppliers. ...
more infohttp://www.chinachemnet.com/Products/Pharmaceuticals%20and%20Biochemicals/Antiparasitics%20and%20antispirochete%20agents/Directory-1.html

Special Grade 99%min, Special Grade 99%min Suppliers and Manufacturers at Alibaba.comSpecial Grade 99%min, Special Grade 99%min Suppliers and Manufacturers at Alibaba.com

Antiparasitic Agents 99%min Triclabendazole pharmaceutical grade US $0-1 / Kilogram 1 Kilogram (Min. Order) ...
more infohttp://www.alibaba.com/showroom/special-grade-99%2525min.html

Sulfachloropyrazin, Sulfachloropyrazin Suppliers and Manufacturers at Alibaba.comSulfachloropyrazin, Sulfachloropyrazin Suppliers and Manufacturers at Alibaba.com

Antiparasitic Agents Sulfachloropyrazine Sodium Monohydrate 102-65-8 US $1-2 / Kilogram ...
more infohttp://www.alibaba.com/showroom/sulfachloropyrazin.html

Lefunomide
        -
        Immunosuppressive Agents,  Antivirals,  Antiparasitics,  Antineoplastic Agents,  Anti-inflammatory...Lefunomide - Immunosuppressive Agents, Antivirals, Antiparasitics, Antineoplastic Agents, Anti-inflammatory...

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomides inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis ...
more infohttp://pharmacycode.com/Lefunomide.html

Vitamin Drugs, Antiparasitic Drugs, Antifungal Agents, Veterinary Drug - KeMingVitamin Drugs, Antiparasitic Drugs, Antifungal Agents, Veterinary Drug - KeMing

Hebei KeMing Medicines Co., Ltd was founded in 1999, is a formal pharmaceutical trading enterprise owned the Drug Business License and GSP.
more infohttps://www.km-medicine.com/

Leflunomidum [Inn-Latin]
        -
        Immunosuppressive Agents,  Antivirals,  Antiparasitics,  Antineoplastic Agents, ...Leflunomidum [Inn-Latin] - Immunosuppressive Agents, Antivirals, Antiparasitics, Antineoplastic Agents, ...

Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA). RA is an auto-immune disease characterized by high T-cell activity. T cells have two pathways to synthesize pyrimidines: the salvage pathways and the de novo synthesis. At rest, T lymphocytes meet their metabolic requirements by the salvage pathway. Activated lymphocytes need to expand their pyrimidine pool 7- to 8-fold, while the purine pool is expanded only 2- to 3-fold. To meet the need for more pyrimidines, activated T cells use the de novo pathway for pyrimidine synthesis. Therefore, activated T cells, which are dependent on de novo pyrimidine synthesis, will be more affected by leflunomides inhibition of dihydroorotate dehydrogenase than other cell types that use the salvage pathway of pyrimidine synthesis ...
more infohttp://pharmacycode.com/Leflunomidum_%5BInn-Latin%5D.html

PLOS Neglected Tropical Diseases: Publishing science, accelerating researchPLOS Neglected Tropical Diseases: Publishing science, accelerating research

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase Lisa Sharling, ...
more infohttps://journals.plos.org/plosntds/issue?id=10.1371/issue.pntd.v04.i08

Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin | Antimicrobial Agents and ChemotherapyAntiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin | Antimicrobial Agents and Chemotherapy

MGM may thus prove to be a promising new antiparasitic agent.. MATERIALS AND METHODS. Drugs.MGM (see Fig. 2) was obtained from ... brucei replication in vivo and suggest its possible use as an antiparasitic agent of therapeutic value. ... Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin. Pedro Bonay, Isabel Durán-Chica, Manuel Fresno, ... Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin. Pedro Bonay, Isabel Durán-Chica, Manuel Fresno, ...
more infohttps://aac.asm.org/content/42/10/2668

Patent US4378353 - Novel C-076 compounds - Google PatentsPatent US4378353 - Novel C-076 compounds - Google Patents

The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed. ... Process for preparing antiparasitic agents. US5840704 *. Mar 23, 1993. Nov 24, 1998. Pfizer Inc.. Antiparasitic agents and ... Antiparasitic agents. US5188944 *. Sep 19, 1991. Feb 23, 1993. Merck & Co., Inc.. Process for the glycosylation of avermectin ... Antiparasitic agents. US20090111759 *. Mar 8, 2007. Apr 30, 2009. Morten Pedersen. Synergistic Combination of Glutamate-and ...
more infohttp://www.google.com/patents/US4378353?dq=%22edwin+asa+markham%22
  • Additionally, antibacterial and antifungal agents that can also be used for treatment of protozoal infections, such as the 5-nitroimidazoles, trimethoprim-sulfamethoxazole, azithromycin, and amphotericin, are not discussed in detail here, but their general indications for parasitic infections are shown in Tables 1 and 2. (monash.edu)
  • The flagellated protozoan Trypanosoma cruzi is the etiologic agent of American trypanosomiasis (Chagas' disease), a major public health problem in many Latin American countries, with an estimated 15 million people infected. (asm.org)
  • Vinyl sulfones as antiparasitic agents and a structural basis for drug design. (nih.gov)
  • Together with other significant structural differences, this provides a possible explanation of the lower affinity of the parasite ENR enzyme family for aminopyridine-based inhibitors, suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials. (strath.ac.uk)
  • This section of the market research report includes analysis of major raw materials suppliers, manufacturing equipment suppliers, major players of the Antiparasitic Agents industry, key consumers, and supply chain relationship. (medgadget.com)
  • However, the lack of financial incentives to develop new agents is a major limitation to the future of antiparasitic chemotherapy. (monash.edu)
  • Due to the effects of MGM on the Golgi and on the replication of enveloped viruses, we decided to test whether it has any antiparasitic activity. (asm.org)
  • The Antiparasitic Agents market provides detailed market segment level data on the international market. (medgadget.com)
  • Tribendimidine is a promising new agent for treatment of liver flukes (clonorchiasis and opisthorchiasis), but trials are still under way, and it has not yet been approved for use, so it is not discussed. (monash.edu)