Drugs used to treat or prevent parasitic infections.
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Substances that are destructive to protozoans.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.
The acquired form of infection by Toxoplasma gondii in animals and man.
The deliberate and methodical practice of finding new applications for existing drugs.
The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.
Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.
A phylum of unicellular parasitic EUKARYOTES characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
Compounds that contain a BENZENE ring fused to a furan ring.
A plant genus in the family Boraginaceae, order Lamiales, subclass Asteridae. This is the True Heliotrope that should not be confused with an unrelated plant sometimes called Garden Heliotrope (VALERIAN).
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.
Payment by a third-party payer in a sum equal to the amount expended by a health care provider or facility for health services rendered to an insured or program beneficiary. (From Facts on File Dictionary of Health Care Management, 1988)
Pricing statements presented by more than one party for the purpose of securing a contract.
Hospital department responsible for the purchasing of supplies and equipment.
Inorganic compounds that contain chlorine as an integral part of the molecule.
Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.
A continuous circle of peptide bonds, typically of 2-3 dozen AMINO ACIDS, so there is no free N- or C-terminus. They are further characterized by six conserved CYSTEINE residues that form CYSTINE KNOT MOTIFS.

Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (1/370)

OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.  (+info)

Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. (2/370)

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respectively. Its inhibitory effect on amastigotes is apparently a direct effect on the parasites and is not due to activation of the nitrogen oxidative metabolism of macrophages, since the production of nitric oxide by both unstimulated and recombinant gamma interferon-stimulated macrophages was decreased rather than increased with DMC. The phagocytic activity of macrophages was functioning normally even with DMC concentrations as high as 80 micrograms/ml, as seen by electron microscopy and by the uptake of fluorescein isothiocyanate-labeled beads. Ultrastructural studies also showed that in the presence of DMC the mitochondria of promastigotes were enlarged and disorganized. Despite destruction of intracellular amastigotes, no disarrangement of macrophage organelles were observed, even at 80 micrograms of DMC/ml. These observations suggest that DMC is selectively toxic to the parasites. Its simple structure may well enable it to serve as a new lead compound for the synthesis of novel antileishmanial drugs.  (+info)

Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. (3/370)

The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.  (+info)

Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. (4/370)

In persons with onchocerciasis, topical application of the anthelminthic diethylcarbamazine (DEC) induces clinical and histologic responses similar to acute papular onchodermatitis, including recruitment of eosinophils to the skin. To determine whether the eosinophil chemokine eotaxin is likely to be associated with eosinophil recruitment in onchodermatitis, DEC was applied to a 5-cm2 area on the skin of infected persons, and biopsies were taken from lesions 24 h later. Histologic analysis showed elevated dermal and epidermal eosinophils compared with tissue from an adjacent (untreated) site. Reverse transcription-polymerase chain reaction showed that eotaxin gene expression in DEC-treated skin was elevated 2- to 17-fold compared with control tissue. Eotaxin immunoreactivity was noted in mononuclear cells and eosinophils in the perivascular region of the dermis and in lymphatic and vascular endothelial cells. Together, these observations are consistent with a role for eotaxin in recruitment of eosinophils to the dermis in early stage onchocercal skin disease.  (+info)

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. (5/370)

The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decreased locomotion, and bang sensitivity. Binding assays using glc(1) head membranes showed a marked decrease in the affinity for nodulisporic acid and ivermectin. A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was introduced into a recombinant DmGluClalpha, and RNA encoding wild-type and mutant subunits was injected into Xenopus oocytes. Nodulisporic acid directly activated wild-type and mutant DmGluClalpha channels. However, mutant channels were approximately 10-fold less sensitive to activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providing direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.  (+info)

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons. (6/370)

The gamma-aminobutyric acid (GABA) receptor is an important site of action of a variety of chemicals, including barbiturates, benzodiazepines, picrotoxin, bicuculline, general anesthetics, alcohols, and certain insecticides. Fipronil is the first phenylpyrazole insecticide introduced for pest control. It is effective against some insects that have become resistant to the existing insecticides. To elucidate the mechanism of fipronil interaction with the mammalian GABA system, whole-cell patch-clamp experiments were performed using rat dorsal root ganglion neurons in primary culture. Fipronil suppressed the GABA-induced whole-cell currents reversibly in both closed and activated states. The IC(50) values and Hill coefficients for fipronil block of the GABA(A) receptor were estimated to be 1.66 +/- 0.18 microM and 1.23 +/- 0.14 for the closed receptor, respectively, and 1.61 +/- 0.14 microM and 0.96 +/- 0.06 for the activated receptor, respectively. The association rate and dissociation rate constants of fipronil effect were estimated to be 673 +/- 220 M(-1) s(-1) and 0.018 +/- 0.0035 s(-1) for the closed GABA(A) receptor, respectively, and 6600 +/- 380 M(-1) s(-1) and 0.11 +/- 0.0054 s(-1) for the activated GABA(A) receptor, respectively. Thus, both the association and dissociation rate constants of fipronil for the activated GABA(A) receptor are approximately 10 times as large as those for the closed receptor. Experiments with coapplication of fipronil and picrotoxinin indicated that they did not compete for the same binding site to block the receptor. It is concluded that although fipronil binds to the GABA(A) receptor without activation, channel opening facilitates fipronil binding to and unbinding from the receptor.  (+info)

GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. (7/370)

1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects. 2. Expression of glc-3 cRNA in XENOPUS oocytes resulted in the formation of homo-oligomeric L-glutamate-gated chloride channels with robust and rapidly desensitizing currents, an EC(50) of 1.9+/-0.03 mM and a Hill coefficient of 1.5+/-0.1. GABA, glycine, histamine and NMDA all failed to activate the GLC-3 homo-oligomer at concentrations of 1 mM. The anthelminthic, ivermectin, directly and irreversibly activated the L-glutamate-gated channel with an EC(50) of 0.4+/-0.02 microM. 3. The GLC-3 channels were selective for chloride ions, as shown by the shift in the reversal potential for L-glutamate-gated currents after the reduction of external Cl(-) from 107.6 to 62.5 mM. 4. Picrotoxinin failed to inhibit L-glutamate agonist responses at concentrations up to 1 mM. The polycyclic dinitrile, 3,3-bis-trifluoromethyl-bicyclo[2,2,1]heptane-2,2-dicarbonitrile (BIDN), completely blocked L-glutamate-induced chloride currents recorded from oocytes expressing GLC-3 with an IC(50) of 0.2+/-0.07 microM. The phenylpyrazole insecticide, fipronil, reversibly inhibited L-glutamate-gated currents recorded from the GLC-3 receptor with an IC(50) of 11.5+/-0.11 microM. 5. In this study, we detail the unusual antagonist pharmacology of a new GluCl subunit from C. elegans. Unlike all other native and recombinant nematode GluCl reported to date, the GLC-3 receptor is insensitive to picrotoxinin, but is sensitive to two other channel blockers, BIDN and fipronil. Further study of this receptor may provide insights into the molecular basis of non-competitive antagonism by these compounds.  (+info)

Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. (8/370)

The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several techniques including DNA fragmentation assay and in situ and cytofluorometry terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling methods and YOPRO-1 staining allowed us to demonstrate that potassium antimonyl tartrate, an Sb(III)-containing drug, was able to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum at low concentrations (10 microg/ml). This observation was in close correlation with the toxicity of Sb(III) species against axenic amastigotes (50% inhibitory concentration of 4.75 microg/ml). Despite some similarities to apoptosis, nuclease activation was not a consequence of caspase-1, caspase-3, calpain, cysteine protease, or proteasome activation. Altogether, our results demonstrate that the antileishmanial toxicity of Sb(III) antimonials is associated with parasite oligonucleosomal DNA fragmentation, indicative of the occurrence of late events in the overall process of apoptosis. The elucidation of the biochemical pathways leading to cell death could allow the isolation of new therapeutic targets.  (+info)

TY - CHAP. T1 - Antiparasitic Agents. AU - Leder, Karin. AU - McGuinness, Sarah L. AU - Weller, Peter F. PY - 2019. Y1 - 2019. N2 - A number of effective antiprotozoal and anthelmintic drugs are currently available. Antiparasitic agents are important both for therapy of infected individual patients and for control of parasitic infections at the community level. Large-scale chemotherapy is reducing transmission, morbidity, and mortality of certain infections, including lymphatic filariasis, onchocerciasis, schistosomiasis, and infections with intestinal nematodes. However, the lack of financial incentives to develop new agents is a major limitation to the future of antiparasitic chemotherapy. Emerging resistance among parasites, lack of effective antiparasitic vaccines, and the enormous burden of disease worldwide also pose challenges to the effective management of parasitic infections. This chapter focuses on the mechanisms of action, pharmacology, clinical utility, and adverse effects of common ...
The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic Agents market report addresses f
The invention provides novel compounds having the formula: ##STR1## wherein R when taken individually is H; R1 when taken individually is H or OH; R and R1 when taken together represent a double bond; R2 is an alpha-branched C3 -C8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C3 -C8 cycloalkyl, C5 -C8 cycloalkenyl or C5 -C8 cycloalkylalkyl group, any of which may be substituted by methylene or one or more C1 -C4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be substituted by one or more C1 -C4 alkyl groups or halo atoms; R3 is hydrogen or methyl; R4 is H or 4-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy with the proviso that when R2 is alkyl it is not isopropyl or sec-butyl; when R4 is H, each of R and R1 is H, and R2 is not methyl or ethyl; and when R4 is H, R is H, R1 is OH, and R2 is not 2-buten-2-yl, 2-penten-2-yl or 4-methyl-2-penten-2-yl. The compounds are broad spectrum antiparasitic agents having utility as
The U.S. small ruminant industry needs new antiparasitic drugs, and the sustainable use of these drugs will help maintain their effectiveness for as long as possible.
Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a terrible toll of human life, health and productivity, especially in tropical and subtropical regions, and are also highly significant in animal health worldwide. Antiparasitic drugs are the mainstays of control of most of these diseases, but in many cases current therapies are inadequate and in some the situation is deteriorating because of drug resistance. Microtubules, as essential components of almost all eukaryotic cells, are proven drug targets in many helminth diseases and show promise as targets for the development of new antiprotozoal drugs. Objective: This article reviews the chemistry of the microtubule inhibitors in current use and under investigation as antiparasitic agents, their activities against the major parasites and their mechanisms of action. New directions in both inhibitor chemistry and biological evaluation are discussed. Conclusions: The most promising immediate avenues for discovery and
Six medical students inhabiting a centuries-old, rat-infested house in Lübeck, in northern Germany, were suffering from itching papules and seropapules. Prior to these patients visit to our institute, their conditions had been diagnosed as pediculosis, scabies, or pulicosis and treated unsuccessfully with the antiparasitic agent lindane (0.3%). The final diagnosis, tropical rat mite dermatitis, was based on the identification of the arthropod Ornithonyssus bacoti, which has an unsegmented body with eight legs. No treatment was recommended, and the dermatitis disappeared within 2 weeks. Measures taken to prevent reinfestation included extermination of the rats and treatment of the rooms of the house with the acaricide benzyl benzoate. Because the mite O. bacoti spends a relatively short time on a host and penetrates the skin for feeding only, the application of an antiparasitic agent is not necessary. If indicated, treatment should be symptomatic.. ...
Abstract. To identify known drugs with previously unrecognized anticancer activity, we compiled and screened a library of such compounds to identify agents cyt
0069]Particularly preferred compounds according to formula (I) include: [0070]N-[1-cyano-1-(5-cyano-2,3-dihydro-1-benzofuran-2-yl)ethyl]-4-[(trif- luoromethyl)thio]benzamide, [0071]N-{(1R*)-1-cyano-1-[(2R*)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]eth- yl}-4-[(trifluoromethyl)thio]benzamide, [0072]N-{(1R)-1-cyano-1-[(2R)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0073]N-{(1S)-1-cyano-1-[(2S)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0074]N-{(1R*)-1-cyano-1-[(2S*)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]eth- yl}-4-[(trifluoromethyl)thio]benzamide, [0075]N-{(1R)-1-cyano-1-[(2S)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0076]N-{(1S)-1-cyano-1-[(2R)-5-cyano-2,3-dihydro-1-benzofuran-2-yl]ethyl- }-4-[(trifluoromethyl)thio]benzamide, [0077]N-[1-cyano-1-(5-cyano-2,3-dihydro-1-benzofuran-2-yl)ethyl]-4-(trifl- uoromethoxy)benzamide, ...
Press Release issued Aug 2, 2017: The Animal Parasiticides Market is growing tremendously due to the increasing trend of pet adoption amongst people in developed as well as developing economies. However, the cost associated with animal parasiticides products, heavy expenditure on R & D for new product development and stringent regulatory policies related to the approval of animal parasiticides are factors that are adversely affecting the growth of the market.
Antiparasitic drugs are pharmaceuticals cure diseases caused by nematodes, cestodes, trematodes, protozoa, and amoeba. Antiparasitic drugs are highly effective, safe, cost effective drugs.
Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well. Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. Nitazoxanide is an effective first-line treatment for infection by Blastocystis ...
[110 Pages Report] Check for Discount on Global Animal Parasiticides Market Professional Survey Report 2017 report by QYResearch Group. This report studies Animal Parasiticides in Global market, especially in...
Parasitic infections afflict more than half of the worlds population and impose a substantial health burden, particularly in underdeveloped nations, where they are most prevalent. The reach of some parasitic diseases, including malaria, has expanded over the past few decades as a result of factors such as deforestation, population shifts, global warming, and other climatic events. Despite major efforts at vaccine development and vector control, chemotherapy remains the single most effective means of controlling parasitic infections. Efforts to combat the spread of some diseases are hindered by the development and spread of drug resistance, the limited introduction of new antiparasitic agents, and the proliferation of counterfeit medications. However, there are good reasons to be optimistic. Ambitious global initiatives aimed at controlling or eliminating threats such as AIDS, tuberculosis, and malaria have demonstrated some early successes. Recognition of the substantial burden imposed by the ...
Compare prices and find information about Antiparasitics prescription drugs. Antiparasitics are used to treat lice, parasitic infections, and...
Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the prevention and cure of parasitic infections.
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Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic burdens. The rise of drug-resistant parasites has created an urgent need to study their biology in hopes of uncovering new potential drug targets. It has been established that disrupting gene expression by interfering with lysine acetylation is detrimental to survival of apicomplexan (Toxoplasma gondii and Plasmodium spp.) and kinetoplastid (Leishmania spp. and Trypanosoma spp.) parasites. As readers of lysine acetylation, bromodomain proteins have emerged as key gene expression regulators and a promising new class of drug target. Here we review recent studies that demonstrate the essential roles played by bromodomain-containing proteins in parasite viability, invasion, and stage switching and present work showing the efficacy of bromodomain inhibitors as novel antiparasitic agents. In addition, we performed a phylogenetic analysis of ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Alcohol use disorders (AUDs) ranks third in the list of preventable causes of morbidity and mortality in United States having a major national impact affecting over 18 million people and causing over 100,000 deaths annually. The prevalence of AUDs, in combination with limited clinical efficacy of currently approved FDA drugs in the treatment of this disorder signifies the importance for development of novel therapeutic agents. Alcohol is known to modulate a multitude of receptors in the brain to induce its cellular and behavioral effects. Recent electrophysiological findings from our laboratory, coupled with genomic studies, have suggested that the ionotropic receptor, P2X4 receptor (P2X4R) is a critical target that is modulated by ethanol. P2X4R activity has been demonstrated to be inhibited by ethanol at intoxicating and anesthetic concentrations. Recent evidence from our laboratory using electrophysiological strategies has shown that the FDA approved antiparasitic agent, ivermectin (IVM) ...
Zimecterin® Paste kills important internal parasites, including bots and the arterial stages of S. Vulgaris, with a single dose. Zimecterin® Paste is potent antiparasitic agent that is neither a benzimidazole nor an organophosphate. Zimecterin® Paste kills large strongyles, small stro
Raw, unfiltered organic apple cider vinegar (ACV) is full of vitamins, mineral and substances such as carotenoids, flavonoids, isoflavones and protease inhibitors.. These nutrients feed and modulate the immune system and improve skin health. For example, beta-carotene promotes skin regeneration while fiber improves digestive health to flush out toxins.. On the other hand, potassium balances pH balance of the skin to reduce inflammation and irritation.. Vinegar also works as an antibacterial, antifungal and antiparasitic agent to fight any infection causing the skin condition.. Heres how you can use this multipurpose food to heal your skin.. Click NEXT Button below to continue…. ...
Includes information on infection detection and prevention and control, diagnostic technologies, bacteriology, antibacterial, antiviral, antifungal, and antiparasitic agents and susceptibility test methods, virology, mycology, and parasitology.
Includes information on infection detection and prevention and control, diagnostic technologies, bacteriology, antibacterial, antiviral, antifungal, and antiparasitic agents and susceptibility test methods, virology, mycology, and parasitology.
IMPORTANT: There are marked regional and national variations in both parasite fauna and the availability/claims/doses/withhold periods of parasiticides around the world. ALWAYS check the specific product information for the product you are administering and ensure that you comply with local rules. Examples given in this article may be correct for one country but rules may differ in other regions. ...
Petwise is Australias leading wholesaler of livestock parasiticides. Browse our range of cattle tick treatment, sheep tick treatment and much more, and keep your store well-stocked with the essentials. We offer competitive prices and ship nationwide.
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Parasites can cause nasty infections, but they are actually very similar to our own cells. In this lesson, learn about the types of drugs commonly...
Functionalized quinolines are an important group of heterocyclic molecules with diverse, different, and interesting biological and pharmacological activities. Traditionally, several methods have been developed for the construction of this N-heterocyclic ring, but nowadays the functionalization of the quinoli 2019 Focus and Perspective articles
Six nonsmoking, adult, male volunteers participated in the study. Each subject was judged to be in good health on the basis of a physical examination, clinical
Formalin is a liquid formulation of 37% formaldehyde gas dissolved in water. Two brands of formalin, Formalin-F (Natchez Animal Supply, Natchez, Miss.) and Paracide-F (Argent Chemical Laboratories, Redmond, Wash.), have been approved by FDA as parasiticides for use on fish. Formalin is effective against many external parasites, including protozoans and monogenetic trematodes. It is not generally considered the best treatment for external fungal or bacterial infections. Formalin can be delivered in a short-term bath at a concentration of 250 mg/l - or 150 mg/l if water temperature is greater than 70°F (21°C) - for no more than 60 minutes. It can be delivered as an indefinite bath at a concentration of 15 to 25 mg/l. Formalin is an excellent parasiticide for use in tanks and aquaria, but its use in ponds is discouraged because it chemically removes oxygen from the water and can contribute to catastrophic oxygen depletion under pond conditions. This is avoided in tanks and aquaria by always ...
Petwise is Australias trusted online wholesaler of animal and pet supplies. Explore our online range of animal and pet products and keep your store well-stocked with essential items. We offer competitive prices and ship nationwide.
Contributing to the complicated nature of pet parasite control, regulation and availability of these products is not uniform. Some products are considered insecticides and, in the United States, are regulated by the Environmental Protection Agency, while others count as medications and fall under the jurisdiction of the U.S. Food and Drug Administration. Some flea-and-tick control methods are available to pet owners over the counter from pet and big-box stores. Others are available only from veterinary clinics or from pharmacies presented with a prescription from a veterinarian who has examined the pet. ...
DELTA PHARMA is a leading pharmaceutical company in the Egyptian market aiming to step up its rank among all other Arabian pharmaceutical manufacturers, to be one of the top ten generic companies in the region within the upcoming years ...
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Protein Phosphorylation in Parasites Novel Targets for Antiparasitic Intervention by Christian Doerig http://i.imgur.com/3NZhmn5.jpg Pages: 456 Publisher: -- Edition: 1st., 2013
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Dr Butters works in the Glycobiology Institute which is headed by Professor Raymond Dwek. His expertise in glycoprotein biology led to him being contacted by Dr Rossignol.. Dr Rossignol approached our group to see if we could help him find a mechanism of action for thiazolides. If we understand the mechanism better, then well be able to improve drug design, explains Dr Butters.. His group works with small molecules that interfere with the cellular processes responsible for glycoprotein production. He is trying to develop these into drugs against the hepatitis C virus which also uses a viral envelope glycoprotein.. If more can be uncovered about how thiazolides work, this may also open up the possibility of using them in combination with compounds Dr Butters own lab is developing.. We have a known mechanism of action for our compounds, and our initial experiments suggest that the drug works in a slightly different way. Both interfere with glycoprotein maturation of viral envelope proteins, ...
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Problem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of the efficacy of ivermectin pour-on administration against natural Heterakis gallinarum infection in native poultry and also determination the prevalence rate of this parasite in Tabriz area. Approach:In the present study, 120 native poultry were investigated by Egg Per Gram of feces (EPG) feces test. Willis method was applied for feces test and Mack-master slide method was used for counting nematode eggs. After confirming the infection with worms, Ivermectin (0.5 mg kg−1) pour-on was administrated to infected birds. Fecal examination was repeated in 1, 7, 21 and 28 days post treatment. Results: Results showed
BioAssay record AID 626318 submitted by ChEMBL: Antiparasitic activity against amastigotes of Leishmania donovani MHOM/ET/67/L82 infected in rat L6 cells after 72 hrs by by Alamar blue assay.
BioAssay record AID 359724 submitted by ChEMBL: Antiparasitic activity against Toxoplasma gondii infected in HFF cells at 0.1 uM after 48 hrs by [3H]uracil incorporation assay relative to control.
NOSB Deliberates. 10:38 a.m. ET: The NOSB reapproves continued use of several other livestock materials, including oxytocin, magnesium sulfate, magnesium hydroxide, iodine, hydrogen peroxide, glycerin, glucose, flunixin, electrolytes, chlorhexidine, and butorphanol.. 10:35 a.m. ET: The NOSB reapproves the continued use of the parasiticide moxidectin. (Cornucopias analysis of the parasiticide issues begins at page 157 here: http://bit.ly/1LxCzWh). 10:33 a.m. ET: More discussion occurred over the parasiticide ivermectin. Members talked about its impact on the environment, effectiveness, and need. Several members noted their reluctance to remove a material used by livestock farmers. When voting took place, 6 supported removal, with only 4 opposing and 4 abstaining. This keeps ivermectin on the National List but again, this would not have been the case had the previous Sunset rules been in place.. 10:29 a.m. ET: The NOSB unanimously reapproves the use of the parasiticide fenbendazole.. 10:01 a.m. ...
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Melbourne researchers say an anti-parasitic drug commonly used to combat head lice has been found to kill the virus that causes COVID-19 in the lab within 48 hours.
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Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discovery of innovative drug candidates. A first series of inhibitors has been prepared on the basis of known substrate specificity and the predicted catalytic mechanism of the enzyme. In this Letter we present the first inhibitors of TbMCA2 with low micromolar enzymatic and antiparasitic activity in vitro combined with low cytotoxicity.. ...
Dechra LimePlus Dip is a concentrated sulfurated lime solution for non-specific dermatoses where sulfurated lime is effective. Antifungal - Antiparasitic. Can be used on dogs, cats, puppies, kittens and horses.
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6. Garlic has anti-parasitic and anti-bacterial properties: Garlic has been known throughout the ages to be an effective anti-bacterial and anti-parasitic agent. Garlic extracts or small amounts of garlic in your diet can help you build up immunity and also kill infections within your system effectively. It is also known to be very effective against tapeworm infestations within the gut. ...
A dose-dependent trypanocidal activity of propolis extract was observed in vitro. All trypomastigotes were killed 1 h after incubation with 10 μg mL−1 of the extract. In vivo, the concentrations of 100, 200, 300 and 400 mg kg−1 administered orally for 10 consecutive days showed no curative effect, and the rats died from the disease. However, rats treated with the two highest concentrations of propolis extract showed higher longevity than the other groups ...
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Davis MI, Patrick SL, Blanding WM, Dwivedi V, Suryadi J, Golden JE, Coussens NP, Lee OW, Shen M, Boxer MB, et al. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrobial Agents and Chemotherapy. 2016 ;60:6023-6033. ...
Antiparasitic drugs have been used successfully to control parasitic diseases in animals for many years, as they are safe, cheap and effective against a broad spectrum of parasites. One drawback of this success appears to be the emergence of drug resistance in many target parasites. Moreover, issues of residues in the food chain and environment have arisen, which threaten their sustained use. Control methods in which vaccines would have a central role provide attractive alternatives. However, while attenuated parasite vaccines have been successful, sub-unit vaccines are still rare. The advent of new techniques in molecular biology allows the elucidation of entire parasite genomes and the identification of individual genes. It is envisaged that a further understanding of parasite genes and the role of their products in parasite biology may lead to the identification of useful antigens, which could then be produced in recombinant systems. However, for this aim to be realised, continued investment ...
Vermanth 400 MG Tablet is an antiparasitic drug used in the prevention and treatment of parasitic infections caused by tapeworms, pinworms and hookworms. Buy Vermanth 400 MG Tablet Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Download Practo app & get your medicines home delivered.
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Scientific Committee Responsible for oversight of programme, organizing sessions, themes and workshops, developing timetable for each session and inviting speakers. Name Andy Fenton (coinfection) Andy Thompson (protozoa population genomics) Carlos Lanusse (Antiparasitic Drugs Pharmacology) Damer Blake (protozoa and vaccine development) Daniel Masiga, ICIPE, Kenya Diana Williams, Cochair Domenico Otranto (filarial nematodes plus EVPC) Title Dr. Andy Fenton BSc MSc PhD Professor RC Andrew Thompson Professor Carlos Lanusse MedVet DrCsVet PhD DipECVPT Dr. Damer Blake BSc MSc PhD PGCVetEd FHEA Dr. Daniel Masiga BSc Msc PhD (Molecular Parasitology) Professor Diana JL Williams Professor Domenico Otranto BVetMed PhD DipEVPC FRES Affiliations Institute of Integrative Biology, University of Liverpool School of Veterinary and Health Sciences, Murdoch University, Australia Director, Veterinary Research Center, National Council of Scientific and Technical Research, Argentina Senior Lecturer in Molecular ...
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parasiticidal definition: with the capacity of destroying parasites, specifically effective at expelling or destroying parasitic worms.; related to or for the nature of a parasiticide.; effective at expelling…
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Adding prescription medicines as a supplement to dog food can be beneficial. However, with the increasing number of available medicines nowadays, its best to know which are safe for your dog, or not.. Some drugs can prevent diseases while others can cure dog ailments. Thus, you should give the right medicine according to the signs and symptoms present.. Heres a list of medications that may be prescribed for your dog at some point in their life:. Pain Relievers - If your dog is in pain, analgesics are an option. Choosing non-steroidal anti-inflammatory drugs (NSAIDs) is even better to decrease your dogs inflammation. As a result, they can feel a whole lot better.. Sedatives - When your dog is anxious, they may harm themselves with unusual behaviors. Sedatives and other behavior-modifying medicines for dogs can calm them and reduce their strange behavior.. Antiparasitics - This type of medication is one of the most vital medicines your dog needs. It can suppress or kill ticks, fleas, ...
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Take each dose with a full glass of water or with meal. The intake of the drug must be different that depends on the type of infection. For treating of malaria, in adults the dosage is 500 mg at the same day of each week. In children the base dose is 5 mg per kg of body weight, 10 mg base/kg must be divided in two doses with break on six hours. For treating of acute attack, in adults the recommended dose is 1 g followed by an additional 500 mg after six to eight hours and a one dose of 500 mg on each of two cumulative days. Take Aralen exactly as directed by your doctor ...
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Problem stomach - I have amibiasis problem stomach problem from many yr. What should I do to recover from that. I get temp relief from tab ciplox tz. Pl reply permanent? Wrong treatment. Ciplox (ciprofloxacin) is an antibiotic used for treatment of bacterial infection. Amoebiasis is caused by e. Histolytica, a protozoan parasite which needs to be treated with an anti-parasitic medication or metronidazole. Would advise confirming diagnosis one year out.
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Ginger is an extremely beneficial root, with potent antibacterial, anti-inflammatory, and anti-parasitic properties. It is a rich source of numerous nutrients, including vitamin C, magnesium, and many minerals. It strengthens the immune system, treats pain, helps digestion, treats heart diseases, and asthma. It is also a popular natural remedy for cleansing the liver and treating … Read more Ginger Tea: Dissolves Kidneys Stones, Kills Cancer Cells And Cleanses Liver - Recipe ...
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Mallo, Natalia; Lamas, Jesús; Leiro, José M. (2014). "Alternative oxidase inhibitors as antiparasitic agents against ... Mallo, N.; Defelipe, A. P.; Folgueira, I.; Sueiro, R. A.; Lamas, J.; Leiro, J. M. (2017). "Combined antiparasitic and anti- ... The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and ... In addition, several compounds of natural origin have also shown in vitro antiparasitic activity: the polyphenols mangiferin ...
... is a fungus species of the genus of Penicillium which produces the antinematodal and antiparasitic agents ... Liesch, J. M.; Wichmann, C. F. (1990). "Novel antinematodal and antiparasitic agents from Penicillium charlesii. II. Structure ...
... is FDA-approved as an antiparasitic agent. Ivermectin is used to treat human diseases caused by roundworms and ... Campbell WC, Fisher MH, Stapley EO, Albers-Schönberg G, Jacob TA (August 1983). "Ivermectin: a potent new antiparasitic agent ... In 2013, this antiparasitic drug was demonstrated as a novel ligand of farnesoid X receptor (FXR), a therapeutic target for ... 2013). "The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism". Nature Communications. 4: 1937. ...
... [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Oral nitazoxanide is an available, approved antiparasitic agent (e.g., against cryptosporidium, giardia) with established ... a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. 2 (1): 43-9. doi:10.1586/14787210.2.1.43. PMID 15482170 ... Agents Chemother. 46 (7): 2116-23. doi:10.1128/aac.46.7.2116-2123.2002. PMC 127316. PMID 12069963. Nitazoxanide (NTZ) is a ...
... antifungal and antiparasitic (including antiprotozoal and antihelminthic) agents. Depending on the severity and the type of ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...
FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in ... For this reason, several FTase inhibitors are undergoing testing as anti-cancer agents. ...
Many commonly used anti-microbial, anti-parasitic, and anti-cancer agents are polyketides or polyketide derivatives, such as ... "Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents". Current ...
They are used in veterinary medicine as antiparasitic agents against worms, ticks and fleas. Like avermectins, milbemycins are ...
... a Novel Antiparasitic Agent". Antimicrobial Agents and Chemotherapy. 61 (1): e01947-16. doi:10.1128/AAC.01947-16. "Chemical ... Barrios contributed to the development of a new anti-parasitic drug. Through a high-throughput drug screen, they found that ...
"Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin". ...
This makes it an ideal target for new antimicrobial agents, anti-parasitic agents, and herbicides. Other enzymes in the ...
"Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent". Frontiers in Cellular and Infection ... "Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent". Frontiers in Cellular and Infection ... Various clinical trials of copper depletion agents have been carried out. In the body, disulfiram is rapidly metabolized to ... Disulfiram has also been identified by systematic high-throughput screening as a potential HIV latency reversing agent (LRA). ...
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The broad-spectrum antiparasitic agent nitazoxanide has shown efficacy against many diarrhea-causing parasites. Other ... Anti-motility agents like loperamide are also effective at reducing the number of stools but not the duration of disease. These ... Another absorbent agent used for the treatment of mild diarrhea is kaopectate. Racecadotril an antisecretory medication may be ... In most of these cases, osmotic diarrhea stops when the offending agent, e.g. milk or sorbitol, is stopped. Exudative diarrhea ...
A clinical trial of another antiparasitic agent, moxidectin (manufactured by Wyeth), began on July 1, 2009 (NCT00790998). A ... The key factor in elimination is mass administration of the antiparasitic drug ivermectin. The initial projection was that the ...
... or antiprotistal refers to an anti-parasitic and anti-infective agent which is active against protists. ... 848-. ISBN 978-1-4496-0594-0. MeSH list of agents 82000563 v t e. ...
Menaker treated sparrows with Dry-Die, an anti-parasitic agent, to eliminate any possible effects of light transferring by ...
Cited 137 times (Aug 2019) Eisenthal, R; Cornish-Bowden, A (6 March 1998). "Prospects for antiparasitic drugs. The case of ... Trypanosoma brucei, the causative agent of African sleeping sickness". The Journal of Biological Chemistry. 273 (10): 5500-5. ...
Ivermectin has become the most common antiparasitic agent used worldwide, but can lead to residual microfilarial load when ...
... , also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of ...
Antiparasitic Agents", Infectious Diseases (Fourth Edition), Elsevier, pp. 1345-1372.e2, ISBN 978-0-7020-6285-8, retrieved 2020 ... Approaches to Design and Synthesis of Antiparasitic Drugs, Elsevier, 25, p. 428, retrieved 2020-01-12 Nagel, Jerod L.; Aronoff ...
It has been used as an astringent, antiseptic, anti-parasitic, anti-tussive, emmenagogue, and anti-spasmodic agent. It was ...
Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ... Agents Chemother. 56 (8): 4103-11. doi:10.1128/AAC.00360-12. PMC 3421617. PMID 22585229. Hoffman PS, Bruce AM, Olekhnovich I, ... Agents Chemother. 58 (8): 4703-12. doi:10.1128/AAC.03112-14. PMC 4136022. PMID 24890599. Evans MC, Buchanan BB (1965). " ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed ...
... or antiparasitic agent. Several antiviral agents are host-directed therapeutics, and simply slow the virus progression rather ... host cell-directed agent". Antimicrobial Agents and Chemotherapy. 53 (12): 5236-44. doi:10.1128/aac.00555-09. PMC 2786354. PMID ... Certain agents also have the ability to reduce bacterial load by enhancing host cell responses even in the absence of ... These immunomodulatory agents can also alter the epithelial cell environments, since they also have a role in innate signalling ...
... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ... chemotherapeutic agent - chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker ...
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Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ... Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic". In Sigel, ... Between 2000 and 2005, twenty new antiparasitic agents were developed or in development. Metal-containing compounds are the ... Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity ...
It covers antimicrobial, antiviral, antifungal, and antiparasitic agents and chemotherapy. The editor-in-chief is Cesar A. ... Antimicrobial Agents and Chemotherapy is a peer-reviewed scientific journal published by the American Society for Microbiology ... "New Editors-in-Chief Announced for ASM's Antimicrobial Agents and Chemotherapy and Microbiology and Molecular Biology Reviews ...
"Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents". Current ...
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The antigen (usually a protein or carbohydrate made by an infectious agent) is bound by the antibody, allowing this type of ... A broad class of drugs known as antiparasitics are used to treat parasitic diseases. ... Identification of an infectious agent for a minor illness can be as simple as clinical presentation; such as gastrointestinal ... Fast and relatively simple biochemical tests can be used to identify infectious agents. For bacterial identification, the use ...
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Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ... Cutting agent[edit]. Quinine is sometimes detected as a cutting agent in street drugs such as cocaine and heroin.[63] ... As a flavoring agent in beverages, quinine is limited to less than 83 parts per million in the United States, and 100​mg⁄l in ... Magill A, Panosian C (July 2005). "Making antimalarial agents available in the United States". The New England Journal of ...
Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or ... When choosing analgesics, the severity and response to other medication determines the choice of agent; the World Health ...
... an antifungal agent, and an antiparasitic agent. ... As an antiparasitic, tiabendazole is able to control roundworms ... Tiabendazole is also a chelating agent, which means it is used medicinally to bind metals in cases of metal poisoning, such as ... It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been ... "Antiparasitic Drugs. Iv. 2-(4'-Thiazolyl)-Benzimidazole, A New Anthelmintic". Journal of the American Chemical Society. 83 (7 ...
It may be used as a nasal/sinus decongestant, as a stimulant,[119] or as a wakefulness-promoting agent.[120] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... and anorectic agent.[112] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ... "Phenylisopropylamine stimulants: amphetamine-related agents". In Lemke TL, Williams DA, Roche VF, Zito W (eds.). Foye's ...
Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ... Anti-microtubule agents[edit]. Vinca alkaloids prevent the assembly of microtubules, whereas taxanes prevent their disassembly ...
List of agents[edit]. Adrenaline releasing agents[edit]. Main article: Norepinephrine releasing agent ... 3 List of agents *3.1 Adrenaline releasing agents *3.1.1 Common or widely marketed ... since these agents lose effectiveness after a few days. ... Antiparasitics *Antiprotozoals. *Anthelmintics. * ...
Diseases caused by many infectious agents[change , change source]. Some infections are caused by different infectious agents at ... Anti-parasitic medicines like Praziquantel and mebendazole. Some infectious diseases have no treatments that work well. For ... Infection is the invasion of an organism's body tissues by disease-causing agents. The disease is caused by the invading agents ... Immunizations try to make a person have an immune reaction to an infectious agent. This is usually done before the person gets ...
Many species of this family possess medicinal properties and are used as traditional antiparasitic medicine. [25] ... sweetening agents, coffee substitutes and herbal teas. Several genera are of horticultural importance, including pot marigold, ... "Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India". Parasite ...
"Antimicrob Agents Chemother. 42 (12): 3245-50. PMC 106029. PMID 9835521.. *^ Dubner S, Schapachnik E, Riera AR, Valero E (2008 ... Antiparasitic treatment is most effective early in the course of infection, but is not limited to cases in the acute phase. ... "Antimicrob Agents Chemother. 49 (4): 1521-8. doi:10.1128/AAC.49.4.1521-1528.2005. PMC 1068607. PMID 15793134.. ... Agents Chemother. 56 (1): 115-123. doi:10.1128/AAC.05135-11. PMC 3256028. PMID 22037852. Archived from the original on 6 April ...
"Dermatotherapeutic Agents". Ullmann's Encyclopedia of Industrial Chemistry (7th ed.). 2007. doi:10.1002/14356007.a08_301.pub2. ... Kyriakidis I, Tragiannidis A, Munchen S, Groll AH (February 2017). "Clinical hepatotoxicity associated with antifungal agents ... "The cost effectiveness of testing for onychomycosis versus empiric treatment of onychodystrophies with oral antifungal agents ... "Current and emerging azole antifungal agents". Clinical Microbiology Reviews. 12 (1): 40-79. PMC 88906. PMID 9880474 ...
Within the class of medications, there is no clear evidence that one agent works better than another.[1][2] ... In British Columbia, Canada the cost of the PPIs varies significantly from 0.20 CAD to 2.38 CAD per dose while all agents in ... The cost between different agents varies significantly.[1] ... Antiparasitics *Antiprotozoals. *Anthelmintics. * ...
The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... Diuretics increase the urine volume and dilute doping agents and their metabolites. Another use is to rapidly lose weight to ... "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and ...
Agents Chemother. 47 (1): 262-7. doi:10.1128/AAC.47.1.262-267.2003. PMC 149030 . PMID 12499200. Viejo-Díaz M, Andrés MT, Fierro ... antiparasitic, catalytic, anti-cancer, and anti-allergic functions and properties. Lactoferrin hydrolyzes RNA and exhibits the ... Agents Chemother. 48 (4): 1242-8. doi:10.1128/AAC.48.4.1242-1248.2004. PMC 375254 . PMID 15047526. Takakura N, Wakabayashi H, ... Agents Chemother. 43 (11): 2635-41. PMC 89536 . PMID 10543740. Andrés MT, Viejo-Díaz M, Fierro JF (Nov 2008). "Human ...
Stephen W. Page (2008). "10: Antiparasitic drugs". In Jill E. Maddison. Small Animal Clinical Pharmacology. Stephen W. Page, ... Antiparasitic agents. *Household chemicals. *Organochlorides. *Endocrine disruptors. *Phenol ethers. *Pyrethroids. *Acaricides ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ... Chromalveolate antiparasitics,state=autocollapse}} *shows the template collapsed to the title bar if there is a {{navbar}}, a ... Chromalveolate antiparasitics,state=collapsed}} to show the template collapsed, i.e., hidden apart from its title bar ... Chromalveolate antiparasitics,state=expanded}} to show the template expanded, i.e., fully visible ...
Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure,[56] although since cholinesterases are produced in ... Even with proper administration, it is inevitable for some diffusion of agent into the body from the site of application due to ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ...
Saiz, JC; Martín-Acebes, MA «Zika virus: a race in search for antivirals» (en anglès). Antimicrob Agents Chemother., 2017; Mar ... a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains ... Rossignol, JF «Nitazoxanide: A first-in-class broad-spectrum antiviral agent» (en anglès). Antiviral Res, 2014 Oct; 110, pp: 94 ... Antimicrob Agents Chemother, 2017 Sep; 61 (9), pp: e01152-17. DOI: 10.1128/AAC.01152-17 [Consulta: 27 agost 2017]. ...
Antiparasitics - antiprotozoal agents - Chromalveolate antiparasitics (P01). Alveo-. late. Apicom-. plexa. Conoidasida/. ( ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... HMG-CoA reductase inhibitors (statins) for lowering LDL cholesterol inhibitors: hypolipidaemic agents. ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Agents Chemother. 12 (5): 642-6. doi:10.1128/AAC.12.5.642. PMC 429991 . PMID 303498.. ... Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, ... Virtue, RW; Alanis, JM; Mori, M; Lafargue, RT; Vogel, JH; Metcalf, DR (1967). "An anaesthetic agent: 2-orthochlorophenyl, 2- ... a PCP-receptor-acylating agent". Synapse. 1 (5): 497-504. doi:10.1002/syn.890010514. PMID 2850626.. ...
"Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review" (PDF). Respiratory Care. 60 ...
Antiparasitic agents. Class Summary. Parasite biochemical pathways are sufficiently different from the human host to allow ...
The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and ... Antiparasitic agents. EP0001689A1 *. Sep 29, 1978. May 2, 1979. Merck & Co., Inc.. Selective hydrogenation products of C-076 ... The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. They are ... This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but ...
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.. Kerr ID1, Lee JH, Farady CJ, Marion R, Rickert ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ...
2-penten-2-yl or 4-methyl-2-penten-2-yl.The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ... The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. They are ... This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but ... The compounds of the invention are highly active antiparasitic agents having particular utility as anthelmintics, ...
Broad spectrum benzimidazole antiparasitic agent. Reversible inhibits microtubules. Fenbendazole (ab143186) derivative. Orally ... Broad spectrum benzimidazole antiparasitic agent. Reversible inhibits microtubules. Fenbendazole (ab143186) derivative. Orally ...
The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic ... US Antiparasitic Agents Production, Revenue (Value) by Region (20Antiparasitic Agents-2016). *US Antiparasitic Agents Supply ( ... US Antiparasitic Agents Production, Revenue (Value), Price Trend by Type. *US Antiparasitic Agents Market Analysis by ... The Antiparasitic Agents market provides detailed market segment level data on the international market. The Antiparasitic ...
Antiparasitic agents. Class Summary. For reduction in parasitemia and improvement of clinical signs and symptoms of Chagas ... The propensity of both of these agents to induce chromosomal aberrations requires further study. ...
Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents† Rodolfo Lavilla ... Lavilla, R. Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents. ... Lavilla R. Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents. ... "Multicomponent Reactions with Heterocycles: A Source of Novel Scaffolds for Antiparasitic and Antiviral Agents." Proceedings 1 ...
MGM may thus prove to be a promising new antiparasitic agent.. MATERIALS AND METHODS. Drugs.MGM (see Fig. 2) was obtained from ... brucei replication in vivo and suggest its possible use as an antiparasitic agent of therapeutic value. ... Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin. Pedro Bonay, Isabel Durán-Chica, Manuel Fresno, ... Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin. Pedro Bonay, Isabel Durán-Chica, Manuel Fresno, ...
These results suggest that guanabenz may rapidly be repurposed as a novel antiparasitic agent that can dually target ... further highlighting the potential of guanabenz as a novel antiparasitic agent. Collectively, our study validates translational ... Antimicrobial Agents and Chemotherapy Oct 2015, 59 (11) 6939-6945; DOI: 10.1128/AAC.01683-15 ... Antimicrobial Agents and Chemotherapy Oct 2015, 59 (11) 6939-6945; DOI: 10.1128/AAC.01683-15 ...
Study Antimicrobial Agents -Antiparasitics flashcards from Michael McHugh ... Antimicrobial Agents -Antiparasitics Flashcards Preview 4 Pharm Self , Antimicrobial Agents -Antiparasitics , Flashcards ... With the antifilarial agents, what are the inflammatory response and side effects due to? ...
... suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials. ... and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents ... and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. ... antibacterial agents, biological-activity, crystal-structure, escherichia-coli, molecular-basis, enoyl acyl carrier protein ...
Antiparasitic Agents. Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review ... Antiparasitic Agents. Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review ... Antiparasitic Agents. / Leder, Karin; McGuinness, Sarah L; Weller, Peter F.. Manual of Clinical Microbiology. ed. / Karen C. ... Leder, K., McGuinness, S. L., & Weller, P. F. (2019). Antiparasitic Agents. In K. C. Carroll, M. A. Pfaller, M. L. Landry, A. J ...
... agents Catalog is online Antiparasitics and antispirochete agents database of China Antiparasitics and antispirochete agents ... Featured China Antiparasitics and antispirochete agents Products. * Diminazene 536-71-0 ... ,,,. SHANGHAI TRUSTIN CHEMICAL CO., ... and China Antiparasitics and antispirochete agents Suppliers. ...
... further antiparasitic agents. [0160]Examples of antiparasitic agents that may be used in combination with the compounds of ... Patent application title: ANTIPARASITIC AGENTS. Inventors: Stephen Paul Gibson Christelle Lauret Agents: PHARMACIA & UPJOHN ... Patent application title: ANTIPARASITIC AGENTS. Inventors: Stephen Paul Gibson (Sandwich, GB) Christelle Lauret (Sandwich, GB) ... 4,639,771 and DE-19520936); [0168]derivatives and analogues of the general class of dioxomorpholine antiparasitic agents as ...
Process for preparing antiparasitic agents. US5840704 *. 23 Mar 1993. 24 Nov 1998. Pfizer Inc.. Antiparasitic agents and ... Antiparasitic agents. US5206155 *. 10 Aug 1990. 27 Apr 1993. The Kitasato Institute. Microorganism for selective production of ... Although the antiparasitic agents of this invention find their primary use in the treatment and/or prevention of helminthiasis ... Antiparasitic agents. US6706758. 8 Mar 2001. 16 Mar 2004. Bayer Aktiengesellschaft. Combinations of active ingredients with ...
The antiparasitic drugs can be divided into antiprotozoal and antihelminthic drugs. In general, commonly used are highly ...
Anti-parasitic Activity and Safety Assessment of SAR97276A in Children With Uncomplicated Malaria. This study has been ... To assess the antiparasitic activity of intramuscular (IM) SAR97276A based on parasite reduction ratio at 72 hours in pediatric ... An Open-label, Randomized Multicenter Study to Investigate the Anti-parasitic Activity, Pharmacokinetic and Safety of IM ...
... antiparasitic agents Remove constraint Subject: antiparasitic agents Start Over ... Eurytrema; adults; antiparasitic agents; cattle; confocal microscopy; crystal proteins; eggs; esophagus; etiological agents; ... Haematobia irritans; Nellore; antiparasitic agents; calves; cypermethrin; diazinon; ear tags; ears; parasitism; weight gain. ... antiparasitic agents; cytotoxicity; drugs; in vitro studies; nuclear magnetic resonance spectroscopy; raw materials; tandem ...
Mallo, Natalia; Lamas, Jesús; Leiro, José M. (2014). "Alternative oxidase inhibitors as antiparasitic agents against ... Mallo, N.; Defelipe, A. P.; Folgueira, I.; Sueiro, R. A.; Lamas, J.; Leiro, J. M. (2017). "Combined antiparasitic and anti- ... The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and ... In addition, several compounds of natural origin have also shown in vitro antiparasitic activity: the polyphenols mangiferin ...
Guenther, Lyn C C (16 August 2019). "Pediculosis and Pthiriasis (Lice Infestation) Medication: Antiparasitic Agents". emedicine ...
Hebei KeMing Medicines Co., Ltd was founded in 1999, is a formal pharmaceutical trading enterprise owned the Drug Business License and GSP.
Antiparasitic Agents 99%min Triclabendazole pharmaceutical grade US $0-1 / Kilogram 1 Kilogram (Min. Order) ...
Book; Format: print Publisher: Geneva : World Health Organization, 1995Other title: Drugs used in parasitic diseases.Title translated: Fiches modèles OMS d information à l usage des prescripteurs : médicaments utilisés en parasitologie; Modelo OMS de informaciòn sobre prescripción de medicamentos : medicamentos utilizados en las enfermedades parasitarias.Online access: Full text now in IRIS , Full text now in IRIS Availability: Items available for loan: WHO HQ [Call number: QV 253 95WH] (2). Withdrawn (1). ...
Antiparasitic Agents Sulfachloropyrazine Sodium Monohydrate 102-65-8 US $1-2 / Kilogram ...
Hebei Keming Madawa Co, Ltd ilianzishwa mwaka 1999, ni rasmi biashara ya madawa ya biashara inayomilikiwa License Dawa Biashara na GSP.
A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase Lisa Sharling, ...
Antiparasitic agents (1). * B-cell lymphoma (1). * Epidemiology (1). * Parasitic infection (1). ...
anti-inflammatory agent Any compound that has anti-inflammatory effects.. antiparasitic agent A substance used to treat or ... 4-terpineol (CHEBI:78884) has role antiparasitic agent (CHEBI:35442) 4-terpineol (CHEBI:78884) has role apoptosis inducer ( ... 4-terpineol (CHEBI:78884) has role anti-inflammatory agent (CHEBI:67079) 4-terpineol (CHEBI:78884) has role antibacterial agent ... 4-terpineol (CHEBI:78884) has role antineoplastic agent (CHEBI:35610) 4-terpineol (CHEBI:78884) has role antioxidant (CHEBI: ...
antiparasitic agent A substance used to treat or prevent parasitic infections.. radiosensitizing agent A drug that makes ... metronidazole (CHEBI:6909) has role antimicrobial agent (CHEBI:33281) metronidazole (CHEBI:6909) has role antiparasitic agent ( ... antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and ... metronidazole (CHEBI:6909) has role radiosensitizing agent (CHEBI:132992) metronidazole (CHEBI:6909) has role xenobiotic (CHEBI ...
  • As a potential antileukemic agent, ivermectin induced cell death at low micromolar concentrations in acute myeloid leukemia cell lines and primary patient samples preferentially over normal hematopoietic cells. (ashpublications.org)
  • As an antiparasitic, ivermectin binds and activates chloride ion channels in nematodes, so we tested the effects of ivermectin on chloride flux in leukemia cells. (ashpublications.org)
  • Ivermectin is a broad-spectrum antiparasitic agent. (drugs.com)
  • The pharmacokinetics of the histamine H(1)-antagonist cetirizine and the effects of pretreatment with the antiparasitic macrocyclic lactone ivermectin on the pharmacokinetics of cetirizine were studied in horses. (biomedsearch.com)
  • Ivermectin is the first in a series of antiparasitic agents derived from the avermectin family of compounds. (drugs.com)
  • Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. (ajtmh.org)
  • The widely used antiparasitic agent ivermectin is non-polar and has a high tendency to sorb to surfaces. (springer.com)
  • Ivermectin is one of the most important veterinary and human anti-parasitic agents ever," Mackenzie said. (redorbit.com)
  • Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to pharmacokinetic drug interactions. (vetuk.co.uk)
  • The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and acaricides. (google.com)
  • This invention relates to antiparasitic agents and in particular to compounds related to the avermectins and milbemycins but having a novel substituent group at the 25-position and to a process for their preparation. (google.com)
  • The avermectins are a group of broad spectrum antiparasitic agents referred to previously as the C-076 compounds. (google.com)
  • and when R.sup.4 is H, R is H, R.sup.1 is OH, and R.sup.2 is not 2-buten-2-yl, 2-penten-2-yl or 4-methyl-2-penten-2-yl.The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and acaricides. (patentgenius.com)
  • In addition, several compounds of natural origin have also shown in vitro antiparasitic activity: the polyphenols mangiferin and (-)-epigallocatechin-3-gallate (EGCG), curcumin, resveratrol and the synthetic polyphenol propyl gallate. (wikipedia.org)
  • The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents. (patentsencyclopedia.com)
  • The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed. (google.com)
  • To identify known drugs with previously unrecognized anticancer activity, we compiled and screened a library of such compounds to identify agents cytotoxic to leukemia cells. (ashpublications.org)
  • Antiparasitic antibiotics kill or inhibit the growth of parasites that live on or inside another organism. (agscientific.com)
  • These enzymes have therefore emerged as promising targets for antiparasitic drugs. (nih.gov)
  • These data, in conjunction with comparative inhibition kinetics, provide insight into the molecular mechanisms that drive cysteine protease inhibition by vinyl sulfones, the binding specificity of these important proteases and the potential of vinyl sulfones as antiparasitic drugs. (nih.gov)
  • Other major antiprotozoal drugs are also reviewed, including those used for malaria, infections with gastrointestinal protozoa, leishmaniasis, and trypanosomiasis, but an exhaustive list of all antiparasitic drugs is not included. (monash.edu)
  • Throughout this chapter, we indicate which antiparasitic drugs are currently approved by the U.S. Food and Drug Administration (FDA). (monash.edu)
  • The antiparasitic drugs can be divided into antiprotozoal and antihelminthic drugs. (china-sinoway.com)
  • Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. (wikipedia.org)
  • Recent developments in antiparasitic therapy include the expansion of artemisinin-based therapies for malaria, new drugs for soil-transmitted helminths and intestinal protozoa, expansion of the indications for antiparasitic drug treatment in patients with Chagas disease, and the use of combination therapy for leishmaniasis and human African trypanosomiasis. (pubmedcentralcanada.ca)
  • Drugs used for treatment of parasitic illnesses are reffered to antiparasitics. (imedix.com)
  • Treatments for Chagas disease have been administered since the first attempts by Mayer & Rocha Lima (1912, 1914) and up to the drugs currently in use (nifurtimox and benznidazole), along with potential drugs such as allopurinol and first, second and third-generation antifungal agents (imidazoles and triazoles), in separate form. (bioline.org.br)
  • Antiparasitic agents: new drugs on the horizon. (semanticscholar.org)
  • Increased resistance of the parasite and the side-effects of the reference drugs employed in the treatment of giardiasis make necessary to seek new therapeutic agents. (scielo.br)
  • Another agent, nitazoxanide, has both anthelmintic and antiprotozoal activity and is also discussed. (monash.edu)
  • Nitazoxanide is the only broad-spectrum antiparasitic drug that has been approved in the United States for treatment of cryptosporidiosis. (cdc.gov)
  • Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. (wikipedia.org)
  • Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class. (wikipedia.org)
  • Nitazoxanide: A New Thiazolide Antiparasitic Agent , LeAnne M. Fox and Louis D. et al . (agscientific.com)
  • Nitazoxanide: A New Thiazolide Antiparasitic Agent. (agscientific.com)
  • 21. The pharmaceutical composition according to claim 20 further comprising a second therapeutic agent. (patentsencyclopedia.com)
  • The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery. (benthamscience.com)
  • In this paper, we aim to present an updated overview of in vitro and in vivo studies that show the significant therapeutic properties of the crude extracts and phytochemicals derived from H. sabdariffa as antimicrobial, antiparasitic, and anticancer agents. (prolekare.cz)
  • Additionally, antibacterial and antifungal agents that can also be used for treatment of protozoal infections, such as the 5-nitroimidazoles, trimethoprim-sulfamethoxazole, azithromycin, and amphotericin, are not discussed in detail here, but their general indications for parasitic infections are shown in Tables 1 and 2. (monash.edu)
  • These studies demonstrate that atovaquone has pronounced in vitro and in vivo antifungal activity against filamentous fungi by disrupting both metal homeostasis and mitochondrial function, and therefore has potential as a novel antifungal agent. (arvojournals.org)
  • Together with other significant structural differences, this provides a possible explanation of the lower affinity of the parasite ENR enzyme family for aminopyridine-based inhibitors, suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials. (strath.ac.uk)
  • The aim of this study was to evaluate the toxicity of parasiticides agent, antimicrobials agent and insecticides on A. franciscana to establish Predicted No-Effect Concentration (PNEC) on marine organisms and obtain guidance levels for the protection of aquatic life. (edu.pe)
  • We have characterized the antibiotic megalomicin (MGM) as an antiparasitic drug against several taxonomically distant parasites. (asm.org)
  • In case of identification of the causative pathogen, an antibiotic or an anti-parasitic agent may be used. (news-medical.net)
  • Vinyl sulfones as antiparasitic agents and a structural basis for drug design. (nih.gov)
  • Here we report that guanabenz, an FDA-approved drug that interferes with translational control, has antiparasitic activity against replicative stages of Toxoplasma and the related apicomplexan parasite Plasmodium falciparum (a malaria agent). (asm.org)
  • This chapter focuses on the mechanisms of action, pharmacology, clinical utility, and adverse effects of common first-line antiparasitic therapies and newer drug alternatives. (monash.edu)
  • Resistance to antiparasitic agents and drug susceptibility testing are dealt with in separate chapters. (monash.edu)
  • Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design , Iain D. Kerr, Ji H. Lee, et al . (agscientific.com)
  • In particular, antibacterial agents are incredibly important worldwide, with the emergence of multi-drug resistant bacteria. (rsc.org)
  • Antimicrobial agents kill or inhibit the growth of microorganisms, and can be sub-divided into several classes depending on the type of microorganism they target. (rsc.org)
  • Its antiparasitic mechanism of action is through binding selectively to certain ion channels present in invertebrate nerve and muscle cells but not present in mammals. (fiercebiotech.com)
  • Antiparasitic agents are important both for therapy of infected individual patients and for control of parasitic infections at the community level. (monash.edu)
  • Emerging resistance among parasites, lack of effective antiparasitic vaccines, and the enormous burden of disease worldwide also pose challenges to the effective management of parasitic infections. (monash.edu)
  • Numerous studies have described the potential use of HSE and its phytochemicals as significant antimicrobial and antiparasitic agents in the treatment of various infections. (prolekare.cz)
  • Malaria remains one of the most important diseases of humans in terms of both mortality and morbidity, with Plasmodium falciparum being the most important infecting agent ( 24 ). (asm.org)
  • If the cause of the diarrhea is detected, and it is due to bacteria or parasites, agents useful against these pathogens may be used. (news-medical.net)
  • Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (labome.org)
  • Parasite biochemical pathways are sufficiently different from the human host to allow selective interference by chemotherapeutic agents in relatively small doses. (medscape.com)
  • The Antiparasitic Agents market report addresses forecast and growth patterns by company, regions and type or application from 2017 to 2021. (medgadget.com)
  • Its convenience, broad spectrum efficacy and wide safety margin make it an excellent antiparasitic product for horses. (drugs.com)
  • Rotavirus is the most common infectious agent associated with diarrhea in the pediatric age group worldwide. (wikipedia.org)
  • The goal of antiparasitics is destruction of the infectious parasitic agents. (imedix.com)
  • The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and spring 2000 in turbot (Scophthalmus maximus) cultivated in the Atlantic Ocean (Galicia, Northwest Spain). (wikipedia.org)
  • Eurytrema coelomaticum is a digenean flatworm of ruminants that is the causative agent of eurytrematosis, a disease of veterinary health concern. (usda.gov)
  • Tonic water contains approximately 80 mg/L quinine sulphate as a flavouring agent. (inchem.org)
  • The flagellated protozoan Trypanosoma cruzi is the etiologic agent of American trypanosomiasis (Chagas' disease), a major public health problem in many Latin American countries, with an estimated 15 million people infected. (asm.org)
  • WHO HQ Library catalog › Results of search for 'su:{Antiparasitic agents. (who.int)
  • Due to the effects of MGM on the Golgi and on the replication of enveloped viruses, we decided to test whether it has any antiparasitic activity. (asm.org)
  • Our findings suggest that guanabenz can be repurposed into an effective antiparasitic with a unique ability to reduce tissue cysts in the brain. (asm.org)
  • Antiparasitic Agents, Vitamins, Amino Aci. (weiku.com)