DiseasesChemicals and DrugsPhenomena and Processes
AntipainProtease InhibitorsLeupeptinsPepstatinsCarbamatesOligopeptidesEndopeptidasesSerine EndopeptidasesSerine ProteasesSerine Proteinase InhibitorsTrypsinCysteine ProteasesDNA-Activated Protein KinaseArginaseAminocaproatesArginineMolecular WeightPolylysineScopolamine HydrobromideEthylaminesKidney Papillary NecrosisAmino AcidsGlutamineCarboxymethylcellulose Sodium
Antipain
An oligopeptide produced by various bacteria which acts as a protease inhibitor.
Protease Inhibitors
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Leupeptins
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.
Pepstatins
N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.
Carbamates
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Oligopeptides
Peptides composed of between two and twelve amino acids.
Endopeptidases
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
Serine Endopeptidases
Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.
Serine Proteases
Peptide hydrolases that contain at the active site a SERINE residue involved in catalysis.
Serine Proteinase Inhibitors
Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.
Trypsin
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
Cysteine Proteases
A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity.
DNA-Activated Protein Kinase
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.
Arginase
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
Aminocaproates
Amino derivatives of caproic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the amino caproic acid structure.
Arginine
An essential amino acid that is physiologically active in the L-form.
Molecular Weight
The sum of the weight of all the atoms in a molecule.
Polylysine
A peptide which is a homopolymer of lysine.
Scopolamine Hydrobromide
An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.
Ethylamines
Kidney Papillary Necrosis
A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Glutamine
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
Carboxymethylcellulose Sodium
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (1/34)

House dust mite (HDM) allergens are important factors in the increasing prevalence of asthma. The lung epithelium forms a barrier that allergens must cross before they can cause sensitization. However, the mechanisms involved are unknown. Here we show that the cysteine proteinase allergen Der p 1 from fecal pellets of the HDM Dermatophagoides pteronyssinus causes disruption of intercellular tight junctions (TJs), which are the principal components of the epithelial paracellular permeability barrier. In confluent airway epithelial cells, Der p 1 led to cleavage of the TJ adhesion protein occludin. Cleavage was attenuated by antipain, but not by inhibitors of serine, aspartic, or matrix metalloproteinases. Putative Der p 1 cleavage sites were found in peptides from an extracellular domain of occludin and in the TJ adhesion protein claudin-1. TJ breakdown nonspecifically increased epithelial permeability, allowing Der p 1 to cross the epithelial barrier. Thus, transepithelial movement of Der p 1 to dendritic antigen-presenting cells via the paracellular pathway may be promoted by the allergen's own proteolytic activity. These results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens.  (+info)

Assembly and activation of HK-PK complex on endothelial cells results in bradykinin liberation and NO formation. (2/34)

Prekallikrein (PK) activation on human umbilical endothelial cells (HUVEC) presumably leads to bradykinin liberation. On HUVEC, PK activation requires the presence of cell-bound high-molecular-weight kininogen (HK) and Zn(2+). We examined the Zn(2+) requirement for HK binding to and the consequences of PK activation on endothelial cells. Optimal HK binding (14 pmol/10(6) HUVEC) is seen with no added Zn(2+) in HEPES-Tyrode buffer containing gelatin versus 16--32 microM added Zn(2+) in the same buffer containing bovine serum albumin. The affinity and number of HK binding sites on HUVEC are a dissociation constant of 9.6 +/- 1.8 nM and a maximal binding of 1.08 +/- 0.26 x 10(7) sites/cell (means +/- SD). PK is activated to kallikrein by an antipain-sensitive mechanism in the presence of HK and Zn(2+) on HUVEC, human microvascular endothelial cells, umbilical artery smooth muscle cells, and bovine pulmonary artery endothelial cells. Simultaneous with kallikrein formation, bradykinin (5.0 or 10.3 pmol/10(6) HUVEC in the absence or presence of lisinopril, respectively) is liberated from cell-bound HK. Liberated bradykinin stimulates the endothelial cell bradykinin B2 receptor to form nitric oxide. Assembly and activation of PK on endothelial cells modulates their physiological activities.  (+info)

Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. (3/34)

Investigations determined that the cell matrix-associated prekallikrein (PK) activator is prolylcarboxypeptidase. PK activation on human umbilical vein endothelial cell (HUVEC) matrix is inhibited by antipain (IC(50)=50 microM) but not anti-factor XIIa antibody, 3 mM benzamidine, 5 mM iodoacetic acid or iodoacetamide, or 3 mM N-ethylmaleimide. Corn trypsin inhibitor (IC(50)=100 nM) or Fmoc-aminoacylpyrrolidine-2-nitrile (IC(50)=100 microM) blocks matrix-associated PK activation. Angiotensin II (IC(50)=100 microM) or bradykinin (IC(50)=3 mM), but not angiotensin 1-7 or bradykinin 1-5, inhibits matrix-associated PK activation. ECV304 cell matrix PK activator also is blocked by 100 microM angiotensin II, 1 microM corn trypsin inhibitor, and 50 microM antipain, but not angiotensin 1-7. 1 mM angiotensin II or 300 microM Fmoc-aminoacylpyrrolidine-2-nitrile indirectly blocks plasminogen activation by inhibiting kallikrein formation for single chain urokinase activation. On immunoblot, prolylcarboxypeptidase antigen is associated with HUVEC matrix. These studies indicate that prolylcarboxypeptidase is the matrix PK activator.  (+info)

Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected A549 lung pneumocytes. (4/34)

Aspergillus fumigatus is an opportunistic pathogenic fungus that predominantly infects the respiratory system. Penetration of the lung alveolar epithelium is a key step in the infectious process. The cytoskeleton of alveolar epithelial cells forms the cellular basis for the formation of a physical barrier between the cells and their surroundings. This study focused on the distinct effects of A. fumigatus on the actin cytoskeleton of A549 lung pneumocytes. Of the 3 major classes of cytoskeletal fibers--actin microfilaments, microtubules, and intermediate filaments--only the actin cytoskeleton was found to undergo major structural changes in response to infection, including loss of actin stress fibers, formation of actin aggregates, disruption of focal adhesion sites, and cell blebbing. These changes could be specifically blocked in wild-type strains of A. fumigatus by the addition of antipain, a serine and cysteine protease inhibitor, and were not induced by an alkaline serine protease-deficient strain of A. fumigatus. Antipain also reduced, by approximately 50%, fungal-induced A549 cell detachment from the plates and reduction in viability. Our findings suggest that A. fumigatus breaches the alveolar epithelial cell barrier by secreting proteases that act together to disorganize the actin cytoskeleton and destroy cell attachment to the substrate by disrupting focal adhesions.  (+info)

Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis. (5/34)

In the present study, we performed enzymatic characterization of Haemaphysalis longicornis serine proteinase (HlSP) with a view to shed light on the mechanisms of blood digestion in the hard ticks. Escherichia coli-expressed recombinant HlSP (rHlSP) was shown to potently hydrolyze the synthetic substrates Bz-(DL)-Arg-pNA, Z-Ala-Ala-Leu-pNA and Suc-Ala-Ala-Ala-pNA and yielded an activity of 31.5, 88.2 and 18.3 mumol/min/mg protein, respectively at an optimum temperature of 25 degrees C. However, the enzyme showed little activity to hydrolyze the substrates Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-MCA and Pyr-Phe-Leu-pNA. The optimum pH for the enzyme was shown to be 4.0 to 5.0. Several inhibitors such as antipain, leupeptin and phenylmethylsulfonyl fluoride (PMSF), specific for serine proteinase were shown to inhibit enzyme activity by 20-82%, while E-64 (specific for cysteine proteinases) and pepstatinA (specific for aspartic proteinases) had shown only little inhibitory effects on it. This is the first report on enzymatic characterization of a functional serine proteinase from the hard ticks.  (+info)

Light-induced D1 protein degradation is catalyzed by a serine-type protease. (6/34)

Light-induced degradation of the D1 protein in isolated spinach photosystem II core preparations was studied after addition of various protease inhibitors. The degradation was selectively inhibited by several serine protease inhibitors in particular diisopropylfluorophosphate. The results demonstrate that the D1 protein is degraded by a serine-type of proteolytic activity that is an integral part of photosystem II.  (+info)

Antipain-induced suppression of oncogene expression in H-ras-transformed NIH3T3 cells. (7/34)

Antipain (AP; 50 micrograms/ml) inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. To determine whether AP effects on transformation are associated with alterations in oncogene expression, NIH3T3 cells were cotransfected with an activated H-ras oncogene and the selectable marker gene aph, and gene expression was quantified. Fifty percent of geneticin-resistant colonies which were exposed to AP failed to express the transformed phenotype as determined by their inability to grow in soft agar. Northern blot analysis of the transformed and nontransformed colonies revealed that suppression of H-ras transformation by AP was associated with a decrease in expression of the exogenously transfected H-ras gene by approximately 4-fold. Expression of the endogenous oncogene c-myc was decreased by approximately 2.5-fold, to levels seen in untransfected cells. AP-treated colonies that retained the transformed phenotype had levels of oncogene expression that were similar to untreated ras-transformed colonies. Southern blot analysis revealed no effects of AP on incorporation or copy number of the H-ras gene.  (+info)

Repression of serotonin secretion by an endogenous Ca2(+)-activated protease in electropermeabilized bovine platelets. (8/34)

Micromolar levels of free calcium ions added to the extracellular medium elicit secretion of serotonin from electropermeabilized bovine platelets in the presence of millimolar levels of Mg-ATP. Such Ca2(+)-dependent secretion of serotonin was almost completely impaired when the permeabilized platelets were preincubated for 1 min at 35 degrees C in 100 microM Ca2+ without Mg-ATP. The half-maximal effect was observed with about 45 microM Ca2+ in the preincubation medium. Inhibitors of serine-thiol protease, such as leupeptin and antipain, suppressed the impairment of the secretion of serotonin by the preincubation with Ca2+. Electron microscopic observation revealed that disorganization of the cytoskeletal structures, in particular of the membrane undercoat and the network of microfilaments, accompanied the impairment of secretion of serotonin. Microfilaments were also found to be dissociated from dense granules that contained serotonin. These morphological changes were also suppressed when antipain was included in the Ca2(+)-preincubation medium. Coincident with these morphological changes, the following biochemical changes were observed in 100 microM Ca2+ but not in the presence of Ca2+ and antipain. The amount of Triton-insoluble cytoskeleton and the acto-myosin content of the dense-granule fraction were markedly decreased. The decrease in Triton-insoluble cytoskeletons was quantitatively correlated with the degree of impairment of secretion of serotonin. Immunoblot analysis of EGTA extracts of the cells showed that the 240-kDa spectrin in platelets was degraded to a 235-kDa fragment, and a 260-kDa actin-binding protein (ABP) in platelets was partially degraded to 190- and 110-kDa components.(ABSTRACT TRUNCATED AT 250 WORDS)  (+info)

Antipain > 50000units/mg | 37691-11-5 | Sigma...Antipain > 50000units/mg | 37691-11-5 | Sigma...
Antipain ([(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal); | 50000units/mg; Chemical structure: peptide; Inhibits serine/cysteine proteases and some trypsin-like proteases; Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases;
https://www.sigmaaldrich.com/catalog/product/sigma/10791?lang=en®ion=US
Antiteratogenic Effects of -Carotene in Cultured Mouse Embryos Exposed to NicotineAntiteratogenic Effects of -Carotene in Cultured Mouse Embryos Exposed to Nicotine
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
https://www.hindawi.com/journals/ecam/2013/575287/ref/
Antipain | Dna-Pk Inhibitor dna-pkinhibitor.comAntipain | Dna-Pk Inhibitor dna-pkinhibitor.com
Product Name: AntipainDescription: Abbr: Alias: Source: Appearance: Pale yellow powderCAS NO: 1345808-25-4 Arginase inhibitor 1 Molecular Weight: 677.2Purity:
http://www.dna-pkinhibitor.com/2017/08/29/Antipain/
Protease Inhibitor A, PIA 100x [PIA100X] - $48.75 Equl offers Enzyme Assay Kits, Reagent Mixtures, Enzymes, Glycobiology,...Protease Inhibitor A, PIA 100x [PIA100X] - $48.75 Equl offers Enzyme Assay Kits, Reagent Mixtures, Enzymes, Glycobiology,...
Protease Inhibitor A, PIA 100x [PIA100X] - A custom concentration cocktail of two inhibitors in EDTA which has been optimized for the inhibition of calcium-dependent endopeptidases, trypsin-like serine proteases, papain and cysteine proteases. Each vial contains 0.02 mg/ml antipain, 0.05 mg/ml leupeptin, and 50 mg/ml EDTA in water. Supplied with an informational insert.
http://www.equl.com/index.php?main_page=product_info&cPath=70_1083_1367&products_id=67634
Prostasin: a novel human serine proteinase: purification, characterization and cloning of its cDNA and gene :: MEDICA, MUSC...Prostasin: a novel human serine proteinase: purification, characterization and cloning of its cDNA and gene :: MEDICA, MUSC...
A novel serine proteinase, designated as prostasin, has been purified from human seminal fluid to apparent homogeneity by DEAE-Sepharose CL-6B and aprotinin-affinity chromatography. The purified protein has an apparent molecular mass of 40 kDa on SDSPAGE. It can be labeled with [14C]diisopropylfluorophosphate and has pIs ranging from 4.5 to 4.8. Prostasin has trypsin-like activity with a pH optimum of 9.0. Its enzymatic activity on synthetic substrates is inhibited by trypsin inhibitors: aprotinin, antipain, leupeptin, and benzamidine. Prostasin is present at a high level in the human prostate gland, moderate levels in colon, lung, kidney, pancreas, salivary gland, liver and bronchi, but it is not detected in the brain, muscle, testis, ventricle, atrium or aorta. A full-length cDNA sequence encoding prostasin was elucidated by PCR and amplification of the 5 and 3 ends of the cDNA. It contains a 1,032-base coding region, a 574-base 3 noncoding region and a 138-base 5 noncoding sequence. ...
http://digital.library.musc.edu/cdm/singleitem/collection/medica/id/163/rec/20
Non-Adiabatic Processes in Field Desorption Phenomena | Springer for Research & DevelopmentNon-Adiabatic Processes in Field Desorption Phenomena | Springer for Research & Development
The field-induced desorption phenomenon [1] of surface atoms or adsorbed molecules gives direct information about the microscopic states of surface atoms. Recently qualitatively different behaviors...
https://rd.springer.com/chapter/10.1007/978-3-642-82423-4_6
Rotational analysis of the electronic emission spectrum of the H2S+ ion radical | Proceedings of the Royal Society of London A:...Rotational analysis of the electronic emission spectrum of the H2S+ ion radical | Proceedings of the Royal Society of London A:...
The emission spectra of H2S+ and D2S+ occurring in the region 400 to 500 nm have been analysed in detail. In the lower 2B1 state both molecules are near oblate asymmetric tops, and from the rotational constants an SH(SD) bond length of 0.1358 nm and an HSH(DSD) angle of 92.9° are obtained. In the 2A1 upper state of both molecules the equilibrium angle is about 127° and the SH(SD) bond length is 0.1369 nm. The barrier to linearity in the excited state is ca. 4400 cm-1 and transitions have been observed from levels both below and above the barrier. The two combining states are shown to be derived from an electronic II state which is split by static Renner interaction. The complicated ro-vibronic structure of the excited state is interpreted in terms of a model in which both the dynamic Renner effect and spin-orbit interaction are included. The 2A1 state of H2S+ is shown to play an intermediate role between the analogous high-barrier molecules such as AsH2 (H ca. 9000 cm-1), and the low barrier ...
http://rspa.royalsocietypublishing.org/content/331/1584/109
kitchen table math, the sequel: Facts, Facts, Facts!kitchen table math, the sequel: Facts, Facts, Facts!
This is also a pet peeve, as it applies to math and science education. When I start a new project, the first thing I have to do is read the existing literature. This requires a HUGE base of knowledge. Our junior and senior chemistry majors are just about able to do this, with support. High school kids arent, typically. Anecdotal evidence of students engaging with the literature almost always involves highly motivated and very bright students being given a selected problem in a field that has a relatively low barrier to entry. The case Im thinking of is a Princeton freshman seminar, where students who chose to be in that particular seminar dealt with articles in developmental biology, carefully chosen to contain as little biochemistry as possible. Im sure that worked great, but it hardly means that all high school kids should be doing that, rather than developing a framework in biology, chemistry, or whatever! ...
http://kitchentablemath.blogspot.com/2009/07/facts-facts-facts.html
Get your full text copy in PDF | Medical Science MonitorGet your full text copy in PDF | Medical Science Monitor
RESULTS: COL6A3 was highly expressed in tissues and cells of bladder cancer. COL6A3 silencing could inhibit the cell proliferation and angiopoiesis. In addition, COL6A3 silencing obviously suppressed the levels of matrix metalloproteinase-2 (MMP2), Matrix metalloproteinase-9 (MMP9), and vimentin. On the contrary, the levels of epithelium-specific cell-cell adhesion molecule (E-cadherin) and tumor inhibitor of metalloproteinase-1 (TIMP-1) were significantly increased. Furthermore, we found that COL6A3 silencing reduced the activity of p-Smad2, p-Smad3, and transforming growth factor β (TGF-β ...
https://www.medscimonit.com/download/index/idArt/909811
Most recent papers with the keyword Endo barrier | Read by QxMDMost recent papers with the keyword Endo barrier | Read by QxMD
Gold(III)-catalyzed cycloisomerization of α-bis(indol-3-yl)methyl alkynols selectively affords 1-(indol-3-yl)carbazoles, in a transformation that takes place through a selective 1,2-alkyl vs 1,2-vinyl migration step in the vinyl-gold intermediate generated from the initial 5-endo-spirocyclization. The reaction proceeds well with either tertiary or secondary starting alkynols as well as with a wide variety of alkyne substituents. The key role of the other indol-3-yl substituent for the unexpected selectivity in the 1,2 rearrangement has also been supported by DFT calculations that reveal a low barrier, two-step mechanism in the alkyl migration path where the second indole significantly stabilizes a carbocationic intermediate ...
https://www.readbyqxmd.com/keyword/3228
Glyos Core Block, Wedge, and Switch Pins | CollectionDXGlyos Core Block, Wedge, and Switch Pins | CollectionDX
Im just going to throw this out there: I LOVE the Block system and Onell Designs approach to vinyl toys. For a while now, vinyl toys, especially of the designer variety, have had an air or stigma around them based on the intention of the form, and debates about customization and artists intent. Onell has bypassed the issue entirely, and is using vinyl to make affordable large scale companion pieces to their figure line with the same potential for building and customization with a relatively low barrier to entry as the PVC figures. With the advent of the Block system, the potential for Glyos vehicles, mechs, spaceships, and whatever else people think up has exploded. The parts are cheap, available individually, and designed to allow for as much or as little tinkering as you can stand. Once youve come up with something, you are left with a big, chunky, durable vinyl toy of your own design. With a common set of parts, everyone can have a different experience, and I love that.. ...
http://www.collectiondx.com/toy_review/glyos_core_block_wedge_and_switch_pins
Publishing Models for Internet CommercePublishing Models for Internet Commerce
One of the points I made earlier in this paper is that publishing (like any successful market) is an ecology, in which players feed each other in a complex web of relationships. As an industry matures, you see two countervailing trends: one is towards differentiation, as certain players specialize in one layer of the business or another; at the same time, there is increasing consolidation, as certain players take a lead in a particular layer. Right now, everyone is trying to do it all on the net: provide software, connectivity, content, transaction support, data warehousing, you name it. As the Internet matures, I expect to see a lot of the same kind of specialization occurring as we have in print. Well come to recognize that the roles of author, publisher, manufacturer, distributor and retailer need not be rolled up into the same package. (As an aside, part of what created the low barrier to entry for OReilly & Associates in print publishing was the existence of a lot of infrastructure that ...
http://www.isoc.org/inet95/proceedings/PAPER/063/html/paper.html
MACOM - Product Detail - MSS30-248-E35MACOM - Product Detail - MSS30-248-E35
Low Barrier Silicon Schottky Diodes: MACOMs MSS30,000 Series of Schottky diodes are fabricated on N-Type epitaxial substrates using proprietary processes that yield the highest FCOs in the industry. Optimum mixer performance is obtained with LO power of -3 dBm to +3 dBm per diode.
http://www.macom.com/products/product-detail/MSS30-248-E35
Cinemaphile: The Best and Worst Movies of 1999Cinemaphile: The Best and Worst Movies of 1999
Why is it necessary to enjoy such a lewd piece of trash? Perhaps because, like certain trashy material, there is much to be explored beneath the flat surface of the animation. Biting fingers of the MPAA board and savoring the wounds, South Park challenges the very stability of the associations film rating system (which, as you may recall, broke an all-time low barrier this summer when it tried to label taunting sexual acts in Eyes Wide Shut with an NC-17, and gratuitous bloodcurdling violence in something like 8MM with a simple R rating). In addition, the movie offers an arrogant slice of evidence in a case built against those who believe media and cinema violence are being intimidated by teenagers who carry guns into schools. No one can take this stuff that seriously; the movie goes so far and pushes so many buttons that, even in the most obvious coincidences, not one single image can be blamed for the decisions made by humans. Life does not intimidate art, and here is a movie that ...
http://www.thecinemaphileblog.com/2000/01/the-best-and-worst-movies-of-1999.html
How To Survive As A New WordPress Service Provider - Speaker DeckHow To Survive As A New WordPress Service Provider - Speaker Deck
My talk at WordCamp Edinburgh 2017 [Day 1] [Track 1]. WordPress has allowed many of us an opportunity to turn our interests and hobbies into a service. The relatively low barrier to entry offers great benefit for service providers, but it also comes with challenges that may not be obvious in the beginning.. For example: how does a new WordPress service provider survive and thrive in the face of increasing competition?. This talk offers a perspective and an approach uniquely tailored to independent practitioners. It is based on lessons learned in the field over the past 3 years, and will focus on the soft-skills, strategies, and mind-set, which a new WordPress service provider might wish to adopt in order to ensure longevity, stability, and satisfaction in their role.. Topical areas specific to WordPress service delivery, such as technical competency, pricing, project co-ordination, and more will be covered; all from the viewpoint of an independent WordPress practitioner.. ...
https://speakerdeck.com/cjwebstudio/how-to-survive-as-a-new-wordpress-service-provider
When curiosity is sparked... deep cycles of learning can occur. - CYCLES OF LEARNINGWhen curiosity is sparked... deep cycles of learning can occur. - CYCLES OF LEARNING
We finished prototypes today and I was absolutely blown away with the way the natural prototyping process happened seamlessly when the end user was clearly defined. The the low barrier to entry associated with this device and the window it opens to the subsequent learning of the interior electronics of the device make this activity one that acts as a perfect inquiry opening for this new course ...
https://www.cyclesoflearning.com/blog/category/invention
4-Week Walking Plan for Weight Loss - Bak2Bay6Store4-Week Walking Plan for Weight Loss - Bak2Bay6Store
The great thing about walking is it has a low barrier to entry: All it takes is a pair of sneakers and some determination to get going. Not only can incorporating it into your regular routine help boost mood levels, but researchers also found moderate-intensity walking showed a similarly visible reduction in risk for h
https://bak2bay6.com/blogs/news/4-week-walking-plan-for-weight-loss-1
Atripla to Raltegravir Switch Study for CNS Toxicity - Full Text View - ClinicalTrials.govAtripla to Raltegravir Switch Study for CNS Toxicity - Full Text View - ClinicalTrials.gov
The majority of individuals who commence treatment for HIV in the UK start with a regimen that includes EFV in combination with other antiretrovirals. These regimens are convenient (once daily dosing) and highly efficacious. However EFV has several potential drawbacks including continued CNS toxicity, the potential for teratogenesis and a low barrier to the development of virological resistance.. Clinically controlled trials frequently reported undesirable nervous system side effects in patients receiving 600 mg EFV with other antiretroviral agents, including dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming. CNS symptoms of moderate to severe intensity were experienced by 19.4% of patients compared to 9.0% of patients receiving control regimens. These symptoms were severe in 2.0% of patients receiving EFV 600 mg daily and in 1.3% of patients receiving control regimens. In clinical studies 2.1% of patients treated with 600 mg of EFV discontinued therapy because of ...
https://clinicaltrials.gov/show/NCT01195467?order=21
Atripla to Raltegravir Switch Study for CNS Toxicity - Full Text View - ClinicalTrials.govAtripla to Raltegravir Switch Study for CNS Toxicity - Full Text View - ClinicalTrials.gov
The majority of individuals who commence treatment for HIV in the UK start with a regimen that includes EFV in combination with other antiretrovirals. These regimens are convenient (once daily dosing) and highly efficacious. However EFV has several potential drawbacks including continued CNS toxicity, the potential for teratogenesis and a low barrier to the development of virological resistance.. Clinically controlled trials frequently reported undesirable nervous system side effects in patients receiving 600 mg EFV with other antiretroviral agents, including dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming. CNS symptoms of moderate to severe intensity were experienced by 19.4% of patients compared to 9.0% of patients receiving control regimens. These symptoms were severe in 2.0% of patients receiving EFV 600 mg daily and in 1.3% of patients receiving control regimens. In clinical studies 2.1% of patients treated with 600 mg of EFV discontinued therapy because of ...
https://clinicaltrials.gov/show/NCT01195467?order=266
Analysis of Process Cost of Blister Machine Shenzhen Yongchangsheng Machinery Manufacturing Co., LtdAnalysis of Process Cost of Blister Machine Shenzhen Yongchangsheng Machinery Manufacturing Co., Ltd
Analysis of Process Cost of Blister Machine-Shenzhen Yongchangsheng Machinery Manufacturing Co., Ltd-The production of blister machines is a labor-intensive production process with low barriers to entry and rapid returns in traditional industries. The main technological processes include sheet feeding, sheet heating, sheet forming under pressure, product size cutting, surface cleaning, counting, and packaging.
http://en.szyongheng.cn/news/543.html
PART I: FIELD DESORPTION MASS SPECTROMETRY OF ALKALI METAL CRYPTATES. by MEI-KUEN. AUPART I: FIELD DESORPTION MASS SPECTROMETRY OF ALKALI METAL CRYPTATES. by MEI-KUEN. AU
Part I. Field desorption (FD) mass spectra have been obtained from a series of alkali metal cryptates formed from {2.2.2}-, {2.2.1}- and {2.1.1}-cryptands with Li(+), Na(+) and K(+) salts of Cl(-), Br(-), I(-), OTs(-) and BPh(,4)(-). Stabilities of these complexes under FD conditions are compared with their thermodynamic stabilities in solution. Differences in these stabilities are attributed to the lack of solvation of ions under FD conditions. A marked anion effect is also observed in FD spectra. This effect is correlated with the recombination energy of the released cation and anion in the gaseous state. Part II. Acid phthalates from isomeric alicyclic alcohols have been studied by field desorption (FD) and electron impact (EI) mass spectrometry. Isomeric acid phthalates gave identical FD spectra and EI spectra. The use of these methods for distinguishing stereoisomers of this type thus proved to be unsuccessful. However, the field ionization (FI) spectra of cis- and trans-4-t-butylcyclohexyl
https://scholar.uwindsor.ca/etd/3008/
Computational Organic Chemistry » 2013 » AugustComputational Organic Chemistry » 2013 » August
The five 7-member rings warp the structure so that it is non-planar. In fact the molecule has negative curvature, reminiscent of a riding saddle. They report the x-ray structure, outside of the fullerenes, the largest hydrocarbon reported by x-ray crystallography. Because of its non-planar geometry, 1 does not pack well and so it is soluble in a variety of solvents.. The authors have obtained the structure of 1 at B3LYP/6-31G(d), shown in Figure 1. The central corranulene component is a shallow bowl, much less shallow than in corranulene itself. This suggests that the compound might flip with a relatively low barrier. The computed barrier is only 1.7 kcal mol-1. Due to the negative curvatures associated with the seven-member rings, 1 is chiral and the ring flipping process leaves the chirality unchanged. A second transition was located that leads to racemization through a transition state of Cs symmetry. The barrier for this racemization is computed to be 18.9 kcal mol-1. Variable temperature 1H ...
http://comporgchem.com/blog/?m=201308
Anti-neutral sphingomyelinase activation associated factor Antibody Products | BiocompareAnti-neutral sphingomyelinase activation associated factor Antibody Products | Biocompare
Compare Anti-neutral sphingomyelinase activation associated factor Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
https://www.biocompare.com/pfu/110447/soids/2269297/Antibodies/neutral_sphingomyelinase_activation_associated_factor
Characterization of a membrane protease from rat submaxillary-gland mitochondria that possess thrombin-like activity |...Characterization of a membrane protease from rat submaxillary-gland mitochondria that possess thrombin-like activity |...
A membrane protease possessing thrombin-like activity was purified to homogeneity from mitochondria of rat submaxillary gland. The molecular mass of the enzyme was determined to be 45 kDa by SDS/PAGE under reducing conditions and by gel filtration on a Sephadex G-100 column. The enzyme is a glycoprotein and has an isoelectric point of 3.25. Maximum activity was observed at pH 10.5. Inhibition by di-isopropyl fluorophosphate, benzamidine, aprotinin and antipain suggested the enzyme to be a serine protease. Other inhibitors such as EDTA, soya-bean trypsin inhibitor, lima-bean trypsin inhibitor, TosLysCH2Cl and chymostatin did not alter the activity. The enzyme showed affinity towards different synthetic substrates (p-nitroanilide derivatives) containing arginine at the P1 position. Kinetic studies revealed that kcat./Km was highest with the substrate N-Bz-Phe-Val-Arg-p-nitroanilide. The enzyme exhibits significant plasma-coagulating activity. The coagulation initiated by the enzyme was not altered ...
http://www.biochemj.org/content/313/1/193
JCI - Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodentsJCI - Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents
The anorexigenic neuromodulator α-melanocyte-stimulating hormone (α-MSH; referred to here as α-MSH1-13) undergoes extensive posttranslational processing, and its in vivo activity is short lived due to rapid inactivation. The enzymatic control of α-MSH1-13 maturation and inactivation is incompletely understood. Here we have provided insight into α-MSH1-13 inactivation through the generation and analysis of a subcongenic mouse strain with reduced body fat compared with controls. Using positional cloning, we identified a maximum of 6 coding genes, including that encoding prolylcarboxypeptidase (PRCP), in the donor region. Real-time PCR revealed a marked genotype effect on Prcp mRNA expression in brain tissue. Biochemical studies using recombinant PRCP demonstrated that PRCP removes the C-terminal amino acid of α-MSH1-13, producing α-MSH1-12, which is not neuroactive. We found that Prcp was expressed in the hypothalamus in neuronal populations that send efferents to areas where α-MSH1-13 is ...
https://www.jci.org/articles/view/37209/figure/1
Spectroscopy and kinetics of atmospheric reservoir species : HOONO, CH3C(O)OONO2, CH3OOH, AND HOCH2OOH - CaltechTHESISSpectroscopy and kinetics of atmospheric reservoir species : HOONO, CH3C(O)OONO2, CH3OOH, AND HOCH2OOH - CaltechTHESIS
Two conformers, cis-cis and trans-perp HOONO, are identified in the 2vOH region by vibrational overtone initiated photodissociation spectroscopy, and the isomerization barrier from the less stable trans-perp to cis-cis HOONO is determined experimentally, statistically, and ab initio to be ~ 40 kJ/mol. This low barrier indicates that only cis-cis HOONO is atmospherically important. The complex vibrational spectroscopy of cis-cis HOONO is assigned with the aid of a simple two-dimensional OH-stretch/torsion coupling model of the planar, partially hydrogen-bound molecule. Combined with nonuniform quantum yield, this model explains the major features in the cis-cis HOONO spectrum. Its application to the fundamental region suggests an upward adjustment of the atmospherically important HOONO/HONO2 product branching ratio in the OH + NO2 association reaction. The rotational spectrum and dipole moment of cis-cis HOONO and DOONO are measured in the submillimeter region to characterize the molecular ...
https://thesis.library.caltech.edu/1547/
Psychablog: 2008Psychablog: 2008
What do these societies have in common: Gotham City before Batman, the Star Wars universe under Emperor Palpatine, the wizarding world of Harry Potter, and the United States under George W. Bush? The citizens of these societies experienced learned helplessness. Whats learned helplessness? It is the type of giving up that happens to people when they are repeatedly or chronically in an aversive situation and nothing they do can stop or help them escape from it. The original research on learned helplessness, by psychologists Bruce Overmeier and Martin Seligman, went like this: A dog was placed in a cage, and received shocks from which it could not escape. After an initial response of agitation and making noises, the dog eventually became passive in response to the shocks-as if it gave up. The dog was then put in a new cage-with two halves that had a low barrier between the halves. If the dog jumped over the barrier when shocked, it could escape the shock. But the dog never did go over the ...
http://psychablog.blogspot.com/2008/
Psychablog: February 2008Psychablog: February 2008
What do these societies have in common: Gotham City before Batman, the Star Wars universe under Emperor Palpatine, the wizarding world of Harry Potter, and the United States under George W. Bush? The citizens of these societies experienced learned helplessness. Whats learned helplessness? It is the type of giving up that happens to people when they are repeatedly or chronically in an aversive situation and nothing they do can stop or help them escape from it. The original research on learned helplessness, by psychologists Bruce Overmeier and Martin Seligman, went like this: A dog was placed in a cage, and received shocks from which it could not escape. After an initial response of agitation and making noises, the dog eventually became passive in response to the shocks-as if it gave up. The dog was then put in a new cage-with two halves that had a low barrier between the halves. If the dog jumped over the barrier when shocked, it could escape the shock. But the dog never did go over the ...
http://psychablog.blogspot.com/2008/02/
Melanoma | Biotech Strategy BlogMelanoma | Biotech Strategy Blog
Todays post focuses on another question from a reader, who asked: How will we decide which therapies to give patients with metastatic melanoma once the new immunotherapies are available?. This is not an easy question to answer, but first lets remember that as little as five years ago there were only treatments such as DTIC (dacarbazine), temozolamide, interferon, chemotherapy and not much else as choices for people with advanced melanoma. Survival rates were generally poor, yet despite the low barrier to entry, many agents failed miserably to beat them. The disease was therefore widely considered to be a graveyard for Pharma R&D.. Fast forward to 2014. We now have several targeted therapies and combinations approved including BRAFV600E (vemurafenib and dabrafenib) and MEK inhibitors (trametinib), as well as a number of others that may soon be on the way in the near term such as cobimetinib in combination with vemurafenib. Along similar lines, GSK recently announced that the combination of ...
https://biotechstrategyblog.com/category/cancer/melanoma/
Every Little Thing You Dont Know About Tree Service Might Probably Amaze YouEvery Little Thing You Dont Know About Tree Service Might Probably Amaze You
Because the landscaping profession has a generally low barrier of entry, homeowners need to be particularly vigilant in checking references and finding out about a companys track record. Mary Ellen Burton says be wary of so-called pickup truck landscapers. These nefarious gardeners will affix magnetic signs to their trucks as identification rather than using the more permanent painted-on logos. But their inexperience can do lasting damage. Burton says these landscapers will commit such mistakes as applying too little mulch to soil or planting a tree too deeply. She has even seen landscaped homes with Leyland cypress planted near the front door -- a major foliage faux pas. Typically, Leylands are used as a screening plant, says Burton, but if you plant one too close to the house, in two years it will grow to be as tall as your entryway. To avoid such foul-ups, make sure the landscaper has liability insurance (about $1 million is a reasonable amount of coverage), and vet him through the ...
http://travelsofthethaumaturge.blogspot.com
Characterization of Two CHO Variants in Respect to MNNG-Induced Cell Killing, Mutations, and Repair of Methylated DNA Bases |...Characterization of Two CHO Variants in Respect to MNNG-Induced Cell Killing, Mutations, and Repair of Methylated DNA Bases |...
Two Chinese hamster ovary (CHO) cell variants differ substantially in their sensitivity to N-methyl-N -nitro-N-nitrosoguanidine (MNNG). The resistant clone (Cl 3) was isolated from the sensitive...
https://link.springer.com/chapter/10.1007/978-1-4684-5269-3_37
RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy...RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy...
TY - JOUR. T1 - RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation. AU - Matòšková, Broňa. AU - Wong, William T.. AU - Nomura, Nobuo. AU - Robbins, Keith C.. AU - Di Fiore, Pier Paolo. PY - 1996. Y1 - 1996. N2 - We isolated a cDNA encoding a protein, RN-tre, which shows homology to the N-terminus of the tre oncogene product and has SH3-binding ability as well as an evolutionarily conserved domain, termed TrH, with protein-binding ability in vitro. In the present study, we identify the product of the RN-tre gene as a 97-100 kDa protein. We demonstrate stable association in vivo and in vitro between RN-tre and eps8, mediated by the SH3 domain of the latter. In vitro, RN-tre displayed remarkable preference for binding to the eps8-SH3, as compared to eight other SH3s. The Kd for the in vitro interaction between RN-tre and eps8-SH3 was between 10-8 and 10-7 M. A role for RN-tre in cell proliferation was ...
https://moh-it.pure.elsevier.com/en/publications/rn-tre-specifically-binds-to-the-sh3-domain-of-eps8-with-high-aff
Effect of DTT on prolyl oligopeptidase levels in plasma | Open-iEffect of DTT on prolyl oligopeptidase levels in plasma | Open-i
Effect of DTT on prolyl oligopeptidase levels in plasma from healthy and RR-MS patients. POP activity in plasma from healthy controls (white bar) and RR-MS pati
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2864237_1742-2094-7-23-5&req=4
TNO Repository search for: subject:Radiation responseTNO Repository search for: subject:Radiation response
Rat R2k rhabdomyosarcoma cells were transfected with the human H-ras oncogene, which resulted in increased resistance to cell kill in vitro by a single dose of 137Cs γ-rays. A subline carrying one oncogene showed an increase in the quasi-threshold dose (D(q)) from 0.88 to 1.48 Gy. Another subline containing six oncogenes not only had an increased D(q) of 1.59 Gy but also showed an increase in the dose reducing cell survival to a fraction of e-1 = 0.37 (D0) from 1.25 to 1.76 Gy. Analysis of the cell survival data according to the linear-quadratic formalism indicated that a decrease in the value of the coefficient of the linear component α is associated with a H-ras-mediated increase in radioresistance. In fractionated irradiation experiments it was observed that with a dose of 1 Gy/fraction a 1.8 times higher dose for an isoeffect of 10% cell survival (D10) was needed for a subline with one H-ras oncogene, while with fraction doses of 2 or 4 Gy only a 1.2 times higher D10 was found. This ...
https://repository.tudelft.nl/search/tno/?q=subject:%22Radiation%20response%22
RCSB PDB - 1H2X: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT Literature Report PageRCSB PDB - 1H2X: PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, Y473F MUTANT Literature Report Page
1H2X: Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site
http://www.rcsb.org/pdb/explore/litView.do?structureId=1H2X
eRepo - Distribution of Prolyl Oligopeptidase and its Colocalizations with Neurotranmitters and Substrates in...eRepo - Distribution of Prolyl Oligopeptidase and its Colocalizations with Neurotranmitters and Substrates in...
Publications within this content type and its collections are copyrighted content. Content can be downloaded and printed for personal use. Usage without proper citations and commercial use is prohibited.. ...
https://erepo.uef.fi/handle/123456789/9005
Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in...Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in...
Aerolysin is a major virulence factor produced by the Gram-negative bacterium Aeromonas hydrophila and is a member of the beta-pore-forming toxin family. Two oligomerization-deficient aerolysin mutants, H132D and H132N, have been overproduced, proteolyzed by trypsin digestion and purified. Crystals were grown from the proteolyzed forms and diffraction data were collected for the two mutants to 2.1 and 2.3 A resolution, respectively. The prism-shaped crystals belonged to space group C2. The crystal structure of the mutants in the mature, but not heptameric, aerolysin form will provide insight into the intermediate states in the oligomerization process of a pore-forming toxin.. Keywords: aerolysin ; virulence factors ; Aeromonas hydrophila ; Site-Directed Mutagenesis ; Septicum Alpha-Toxin ; Channel Formation ; Membrane-Channel ; Activation ; Binding ; Complex ; Crystallization ; Proaerolysin ; Diffraction. ...
https://infoscience.epfl.ch/record/172149
IJMS | Free Full-Text | OsPOP5, A Prolyl Oligopeptidase Family Gene from Rice Confers Abiotic Stress Tolerance in Escherichia...IJMS | Free Full-Text | OsPOP5, A Prolyl Oligopeptidase Family Gene from Rice Confers Abiotic Stress Tolerance in Escherichia...
The prolyl oligopeptidase family, which is a group of serine peptidases, can hydrolyze peptides smaller than 30 residues. The prolyl oligopeptidase family in plants includes four members, which are prolyl oligopeptidase (POP, EC3.4.21.26), dipeptidyl peptidase IV (DPPIV, EC3.4.14.5), oligopeptidase B (OPB, EC3.4.21.83), and acylaminoacyl peptidase (ACPH, EC3.4.19.1). POP is found in human and rat, and plays important roles in multiple biological processes, such as protein secretion, maturation and degradation of peptide hormones, and neuropathies, signal transduction and memory and learning. However, the function of POP is unclear in plants. In order to study POP function in plants, we cloned the cDNA of the OsPOP5 gene from rice by nested-PCR. Sequence analysis showed that the cDNA encodes a protein of 596 amino acid residues with Mw ≈ 67.29 kD. In order to analyze the protein function under different abiotic stresses, OsPOP5 was expressed in Escherichia coli. OsPOP5 protein enhanced the
http://mdpi.com/1422-0067/14/10/20204/htm
Ester - WikipediaEster - Wikipedia
Esters contain a carbonyl center, which gives rise to 120° C-C-O and O-C-O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C-O-C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides.[5] The pKa of the alpha-hydrogens on esters is around 25.[6] Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present.[7][8] Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure. ...
https://en.wikipedia.org/wiki/Esters
A secreted cystatin from the tick Haemaphysalis longicornis and its distinct expression patterns in relation to innate immunityA secreted cystatin from the tick Haemaphysalis longicornis and its distinct expression patterns in relation to innate immunity
Proteins capable of selective and specific inhibition of cysteine protease have been identified as cystatins and are isolated from a variety of microbes and tissues of animals and plants. The physiological function of these proteins has been proposed to be the regulation of protein turnover and defe …
https://pubmed.ncbi.nlm.nih.gov/16835018/?dopt=Abstract
weather model jma model - europe - surface pressure [base + 24] | weatheronlineweather model jma model - europe - surface pressure [base + 24] | weatheronline
Weather for UK, Ireland and the world. Sailing, Marine Weather, Weather maps, radar, satellite, climate, historic weather data, information about meteorology, reports, weather warning.
https://www.weatheronline.co.uk/cgi-bin/expertcharts?LANG=en&MENU=0000000000&CONT=euro&MODELL=jma&MODELLTYP=1&VAR=thee&HH=12&BASE=-&WMO=&ZOOM=0
Development of a porcine skeletal muscle cDNA microarray: analysis of differential transcript expression in phenotypically...Development of a porcine skeletal muscle cDNA microarray: analysis of differential transcript expression in phenotypically...
One objective of the red-white muscle experiment was simply to test the function of the newly assembled porcine microarray, from which two gene lists were generated (Tables 1 and 2). Genes that were expected to be differentially expressed and genes that were novel were found on each list. The microarray results validated our prior hypothesis of differential gene expression in red and white muscles, thus demonstrating the functional integrity of our newly constructed microarray. One of the well established distinguishing features of red muscle is its relatively high oxidative phosphorylation capacity, reflected by an abundance of mitochondria in red muscles. It is reassuring that genes from the mitochondrial genome were well represented in the red muscle pool of differentially expressed genes (Table 1). White muscles comprise predominantly more fast-glycolytic fibres than red muscles. Our findings were consistent with expectations, in that most of the 45 clones selected as more highly expressed ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-4-8
Use of protease sensitivity to probe the conformations of newly synthesised mutant forms of mitochondrial aspartate...Use of protease sensitivity to probe the conformations of newly synthesised mutant forms of mitochondrial aspartate...
TY - JOUR. T1 - Use of protease sensitivity to probe the conformations of newly synthesised mutant forms of mitochondrial aspartate aminotransferase. AU - Azzariti, Amalia. AU - Giannattasio, Sergio. AU - Doonan, Shawn. AU - Merafina, Riccardo S.. AU - Marra, Ersilia. AU - Quagliariello, Ernesto. PY - 1995. Y1 - 1995. N2 - Sensitivity to digestion with pronase has been used to show that the precursor form of mitochondrial aspartate aminotransferase, the form lacking the N-terminal presequence, that with a deletion of the first 9 residues and mutants of the mature enzyme in which residue Cys-166 is mutated to alanine or serine, all retain unfolded conformations after synthesis in a reticulocyte lysate. In the presence of lysed mitochondria the various forms of mitochondrial aspartate aminotransferase retained their susceptibilities to pronase in a way that mirrored the efficiencies with which they are imported into intact mitochondria. The results are interpreted as showing that the presequence ...
https://moh-it.pure.elsevier.com/en/publications/use-of-protease-sensitivity-to-probe-the-conformations-of-newly-s
EGO OUT: SEP 17, 2016 LENR UNITY-1ST STAGE: LIVE AND LET LIVEEGO OUT: SEP 17, 2016 LENR UNITY-1ST STAGE: LIVE AND LET LIVE
Using low energy electron (LEE) as a catalyst, the electronic origin of the catalytic strategies corresponding to substrate selectivity, reaction specificity and reaction rate enhancement are investigated for a reversible unimolecular elementary reaction. An electronic energy complementarity between the catalyst and the substrate molecule is the origin of substrate selectivity and reaction specificity. The electronic energy complementarity is induced by tuning the electronic energy of the catalyst. The energy complementarity maximizes the binding forces between the catalyst and the molecule. Consequently, a new electronically metastable high-energy reactant state and a corresponding new low barrier reaction path are resonantly created for a specific reaction of the substrate through the formation of a catalyst-substrate transient adduct. The LEE catalysis also reveals a fundamental \textit{structure-energy correspondence} in the formation of the catalyst-substrate transient adduct. Since the ...
http://egooutpeters.blogspot.com/2016/09/sep-17-2016-lenr-unity-1st-stage-live.html
Housestaff Spotlight: Fall 2018 | Internal Medicine Residency ProgramHousestaff Spotlight: Fall 2018 | Internal Medicine Residency Program
Im currently collaborating with colleagues from GIM, ID, and the ED on a project to quantify the number of blood-borne and sexually transmitted infections diagnosed in patients presenting to Faster Paths, our opioid urgent care clinic. In the midst of the escalating opioid epidemic, low barrier to access programs like Faster Paths have emerged as a new and innovative care delivery model. However, the scope of practice of these clinics is still in flux- our research demonstrates high incidence and prevalence of blood-borne and sexually transmitted infections in this high risk population and justify the inclusion of comprehensive infection screening programs in these care settings.. Im also involved in a quality improvement project to expand access to naloxone for our hospitalized patients via an innovative, EMR-based strategy. We are working with hospital leadership and our EMR to have naloxone automatically added to patients medication reconciliation at the time of hospital discharge, thus ...
http://www.bumc.bu.edu/im-residency/2018/11/08/housestaff-spotlight-fall-2018/
Effects of Heat Stress on Porcine Skeletal Muscle Metabolism - The University of Arizona Campus RepositoryEffects of Heat Stress on Porcine Skeletal Muscle Metabolism - The University of Arizona Campus Repository
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author ...
http://arizona.openrepository.com/arizona/handle/10150/144327
Toward finding the gene for bovine platelet plasmin inhibitor. by Natalie Marie. LabbeToward finding the gene for bovine platelet plasmin inhibitor. by Natalie Marie. Labbe
Bovine platelet plasmin inhibitor (BPPI) is a novel Kunitz inhibitor, recently discovered in platelets (Li, 1992) for which an expression system is sought. Because the proteins origin of synthesis was unknown, a search for a genomic clone was undertaken. PCR was used in an attempt to amplify the BPPI gene from lymphocyte, bovine genomic DNA. The first set of primers used was designed according to the N and C termini of the amino acid sequence of BPPI (P1/P2). These were based on a degenerate nucleotide sequence derived from its amino acid sequence. Amplification with this set of primers was unsuccessful. The second approach in amplifying the gene was to increase the specificity of the primers in the 3 end (P3/P4) using a table of codon usage of the bovine genome. Two successive amplifications led to the formation of a 230 bp fragment. The sequence of this product was not comparable to the degenerate sequence of BPPI. A third set of primers (P6/P7) was designed according to the gene sequence of SI (II)
http://scholar.uwindsor.ca/etd/4404/
Haemaphysalis cinnabarina: Definition with Haemaphysalis cinnabarina Pictures and PhotosHaemaphysalis cinnabarina: Definition with Haemaphysalis cinnabarina Pictures and Photos
Definition of Haemaphysalis cinnabarina with photos and pictures, translations, sample usage, and additional links for more information.
http://lexic.us/definition-of/haemaphysalis_cinnabarina
What Would a Trauma-informed Society Look Like?What Would a Trauma-informed Society Look Like?
Imagine if we started recognizing trauma, pain, grief, and fear without defensiveness or denial. What would a society like that look like?
https://www.madinamerica.com/2016/06/what-would-a-trauma-informed-society-look-like/
A Continuous Culture Study of Growth of Bacillus cereus T | Microbiology SocietyA Continuous Culture Study of Growth of Bacillus cereus T | Microbiology Society
SUMMARY: Growth of an oligosporogenic strain of Bacillus cereus T was studied in continuous culture. The maximum specific growth rate obtained was 0.47 h−1. RNA content increased linearly with increasing growth rate. Protein content decreased at high growth rates, but the DNA content of the culture was not affected by the growth rate. Activities of enzymes involved in glutamate utilization and energy production increased with increasing growth rate. The maximum specific activity for all enzymes assayed was obtained at a dilution rate of about 0.30 h−1. Changing the concentration of zinc or manganese in the medium by as little as 10−7 M from the concentration optimum for growth caused a significant reduction in the steady-state bacterial population. Zinc appeared to affect the efficiency of conversion of substrate to biomass. Manganese was very toxic at concentrations slightly above the concentration optimum for a specific growth rate.
https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-122-1-129
Clostridium septicum definition | Drugs.comClostridium septicum definition | Drugs.com
Definition of Clostridium septicum. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
https://www.drugs.com/dict/clostridium-septicum.html
Efficient degradation in vitro of all intermediate filament subunit proteins by the Ca2+-activated neutral thiol proteinase...Efficient degradation in vitro of all intermediate filament subunit proteins by the Ca2+-activated neutral thiol proteinase...
Vimentin, desmin, glial fibrillary acidic protein, neurofilament triplet proteins, and a mixture of cytokeratins were digested with Ca2+-activated neutral thiol proteinase isolated from Ehrlich ascites tumor (EAT) cells and porcine kidney. All intermediate filament proteins were degraded by the proteinase, although with different rates and Ca2+ optima. These results are in part at variance with our previous statement that the Ca2+-activated proteinase from EAT cells is specific for vimentin and desmin.. ...
http://www.bioscirep.org/content/6/1/57
Ribosomes from Spores of Bacillus cereus T | ScienceRibosomes from Spores of Bacillus cereus T | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/168/3934/991/tab-article-info
A T P γS activates the respiratory burst in electropermeabilized neutrophils: The role of protein kinases | Biochemical Society...A T P γS activates the respiratory burst in electropermeabilized neutrophils: The role of protein kinases | Biochemical Society...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/19/2/77S
Streptomyces michiganensisStreptomyces michiganensis
... produces actinomycin X, antipain and mitomycin. Xue, Jinghua; Wu, Min (27 March 2015). "Cyclic ...
https://en.wikipedia.org/wiki/Streptomyces_michiganensis
Sofia ArealSofia Areal
2009 "An Anti-pain practice", Pró-Évora Group, Évora, Portugal. 2006 "360 degrees in the SUN", Museu de Arte Contêmporanea do ... In 2016 a documentary by Jorge Silva Melo, entitled Sofia Areal: An Anti-Pain Practice was premiered at the São Luíz National ...
https://en.wikipedia.org/wiki/Sofia_Areal
William Thomas RawleighWilliam Thomas Rawleigh
... anti-pain) Oil. All of these products were manufactured by Rawleigh and sold from farmhouse to farmhouse in a buggy drawn by a ...
https://en.wikipedia.org/wiki/William_Thomas_Rawleigh
OligopeptideOligopeptide
Antipain - An oligopeptide produced by various bacteria which acts as a protease inhibitor. Ceruletide - A specific decapeptide ...
https://en.wikipedia.org/wiki/Oligopeptide
Horse welfareHorse welfare
The "anti-pain crop" invented in England is actually as painful as others. The discreet use of electric shocks on racing horses ...
https://en.wikipedia.org/wiki/Horse_welfare
Clinical neurochemistryClinical neurochemistry
... antipain) medications. Sensitization, in the clinical sense of the word, is a phenomenon in which nociceptors in an area beyond ...
https://en.wikipedia.org/wiki/Clinical_neurochemistry
FlurbiprofenFlurbiprofen
Antipain, Baenazin, Benactiv, Biprofin, Biprotec, Bro-Z, Brufen, Brufoz, Cebutid, Clinadol, Coryfin, Dispain, Edolfene, Eyeflur ...
https://en.wikipedia.org/wiki/Flurbiprofen
Jerry Baker (author)Jerry Baker (author)
2003 ISBN 0922433437 Jerry Baker's Anti-Pain Plan, 2004 ISBN 0922433496 Jerry Baker's Backyard Problem Solver, 2004 ISBN ...
https://en.wikipedia.org/wiki/Jerry_Baker_(author)
Madrigal v. QuilliganMadrigal v. Quilligan
While under the influence of anti-pain medication and labor pain, she signed a consent form thinking it was for the c-section ...
https://en.wikipedia.org/wiki/Madrigal_v._Quilligan
List of MeSH codes (D12.644)List of MeSH codes (D12.644)
... antipain MeSH D12.644.456.193 - bradykinin MeSH D12.644.456.193.400 - kallidin MeSH D12.644.456.241 - caerulein MeSH D12.644. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
AntipainAntipain
It was shown to have properties as a protease inhibitors but it had a low IC50 than a antipain. Antipain analogue Y was able to ... A recent research article indicated that antipain Y is a new type of anti-pain analog, which can inhibit the release of ... The antiretroviral drug Nelfinavir is one example of an antipain. It was classified as an antipain after a study published by ... "Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons". The Journal of ...
https://en.wikipedia.org/wiki/Antipain
Anti-painAnti-pain
... may refer to: A colloquial term for analgesia Antipain, a peptide used in biochemical research This disambiguation ... page lists articles associated with the title Anti-pain. If an internal link led you here, you may wish to change the link to ...
https://en.wikipedia.org/wiki/Anti-pain
Antipain - WikipediaAntipain - Wikipedia
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Anti-pain - WikipediaAnti-pain - Wikipedia
Anti-pain may refer to: A colloquial term for analgesia Antipain, a peptide used in biochemical research This disambiguation ... page lists articles associated with the title Anti-pain. If an internal link led you here, you may wish to change the link to ...
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Plasminogen activator inhibitor 1 and Antipain preserve acrosome integrity of bovine spermatozoa during cryopreservation | Arq...Plasminogen activator inhibitor 1 and Antipain preserve acrosome integrity of bovine spermatozoa during cryopreservation | Arq...
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Suppression of the radiation-induced expression of a tumor-associated antigen in human cell hybrids by the protease inhibitor...Suppression of the radiation-induced expression of a tumor-associated antigen in human cell hybrids by the protease inhibitor...
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DihydrochloridePapainInhibitsLeupeptinSerineInflammationProteasesInhibitorsResearchStudyDaysHumanEffectProcess
Dihydrochloride5
  • Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes . (medchemexpress.com)
  • Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. (medchemexpress.com)
  • Antipain dihydrochloride restricts uterine DNA synthesis and function in mice. (medchemexpress.com)
  • The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls [4] . (medchemexpress.com)
  • AEBSF ALLN Antipain, dihydrochloride Aprotini. (gbiosciences.com)
Papain3
  • Antipain is an oligopeptide that is isolated from actinomycetes and used in biochemical research as a protease inhibitor of trypsin and papain. (wikipedia.org)
  • Citation needed}} Antipain is a protease inhibitor, usually 1-2 μg/mL, and is well-against to cathepsin A, cathepsin B, papain and trypsin protease enzymes. (wikipedia.org)
  • Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). (alfa.com)
Inhibits2
  • Antipain analogue Y was able to suppress Trypsin, which inhibits the secretion of an excitatory neuropeptide that leads to inflammation and other disorders. (wikipedia.org)
  • Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. (medchemexpress.com)
Leupeptin2
  • Antipain and leupeptin restrict uterine DNA synthesis and function in mice. (medchemexpress.com)
  • Because this proteolytic activity was strongly inhibited by leupeptin and antipain, it was concluded that this protease was a member of the family of cysteine proteases of C. perfringens . (asm.org)
Serine3
  • It has been crystallised in complexes with carboxypeptidase, which is obtained from wheat, and Leishmania major oligopeptidase B. In both cases, the backbone carbonyl of the terminal arginine of antipain forms a covalent bond to the active site serine in the protease. (wikipedia.org)
  • The effects of different concentrations of two serine protease inhibitors were analyzed, Plasminogen activator inhibitor 1 - PAI-1 (70Æ g, 140Æ g and 210 Æ g) and Antipain (10µg, 50µg and 100µg) as supplementation to bovine semen cryopreservation extender. (bvsalud.org)
  • In conclusion, the serine protease inhibitors , Antipain and PAI-1 (70 and 140Æ g) are able to preserve the acrosome integrity of cryopreserved bovine sperm . (bvsalud.org)
Inflammation1
  • Seraza Antipain and Inflammation uses natural ingredients to help soothe pain and inflammation and boost the regeneration properties of the body. (medisilk.com)
Proteases1
  • used antipain for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells. (bachem.com)
Inhibitors2
  • Protease inhibitors or antipain are enzymes that are used to regulate their performance. (wikipedia.org)
  • It was shown to have properties as a protease inhibitors but it had a low IC50 than a antipain. (wikipedia.org)
Research2
  • A recent research article indicated that antipain Y is a new type of anti-pain analog, which can inhibit the release of neurotransmitter in rat dorsal root ganglion neurons. (wikipedia.org)
  • Anti-pain may refer to: A colloquial term for analgesia Antipain, a peptide used in biochemical research This disambiguation page lists articles associated with the title Anti-pain. (wikipedia.org)
Study4
  • It was classified as an antipain after a study published by Ovid that investigated the in vitro effect of Nelfinavir using proteolytic foot printing and found that it selectively inhibited HER2- positive, a growth factor in breast cancer. (wikipedia.org)
  • During the study, an antipain analogue Y was developed and studied. (wikipedia.org)
  • Testing the Implementation of a Pain Self-Management Support Intervention for Oncology Patients in Clinical Practice: A Randomized Controlled Pilot Study (ANtiPain). (fhsg.ch)
  • Testing the feasibility and effects of a self-management support intervention for patients with cancer and their family caregivers to reduce pain and related symptoms (ANtiPain): Study protocol of a pilot study. (fhsg.ch)
Days1
  • However, it is clear that this is not the only mechanism whereby the inhibitor can exert its effect since suppression was obtained even when antipain was added 10 days post-irradiation, a time when any DNA repair processes would be expected to be over. (utmb.edu)
Human2
  • The effect of the protease inhibitor antipain (1.25 μg/ml) on the radiation-induced expression of a tumor-associated antigen in human cell hybrids has been investigated. (utmb.edu)
  • Sun, C, Colman, M & Redpath, JL 1988, ' Suppression of the radiation-induced expression of a tumor-associated antigen in human cell hybrids by the protease inhibitor antipain ', Carcinogenesis , vol. 9, no. 12, pp. 2333-2335. (utmb.edu)
Effect1
  • Antipain and PAI-1 had no effect on the integrity parameters of the plasma membrane , mitochondrial membrane potential and sperm defects. (bvsalud.org)
Process1
  • A possible explanation for this observation is that antipain may inhibit an error-prone DNA repair process. (utmb.edu)
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Locally made anti-pain device for amputees gets grant from Department of Defense - cleveland.com
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