A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
Simultaneous resistance to several structurally and functionally distinct drugs.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
A calcium channel blocker that is a class IV anti-arrhythmia agent.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
An antimitotic agent with immunosuppressive properties.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
An anthracenedione-derived antineoplastic agent.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Therapeutic act or process that initiates a response to a complete or partial remission level.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Antimetabolites that are useful in cancer chemotherapy.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
A cell line derived from cultured tumor cells.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Compounds with a five-membered heterocyclic ring with two nitrogens and a keto OXYGEN. Some are inhibitors of TNF-ALPHA production.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Phenomena and pharmaceutics of compounds that selectively bind to a specific receptor and trigger a response. They mimic the action of endogenous biochemical molecules. Their effect can be countered by antagonists (DRUG ANTAGONISM).
Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY.
Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A fluorescent probe with low toxicity which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of P-glycoprotein in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
ISOQUINOLINES with a benzyl substituent.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.
A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.
Disease having a short and relatively severe course.
A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
Daunorubicin Idarubicin Doxorubicin Grethe, Guenter; Mitt, Toomas; Williams, Thomas H; Uskokovic, Milan R (1983). "Synthesis of ... Daunosamine is a component of the anthracycline class of antineoplastics, linked to a derivative of naphthacene. It is a ... peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin ...
One example is daunorubicin, which is antileukemic. Some of them show anti-tumoral activity. They embody some claims in herbal ... The antineoplastic Apaziquone. Benzoquinone compounds are a metabolite of paracetamol. Many natural and artificial coloring ... a reagent in organic chemistry Daunorubicin, an anticancer drug A large scale industrial application of quinones is for the ...
... (also LY-335979) is an experimental antineoplastic drug. In 2010, it was announced that a phase III trial for the ... "Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory ...
... Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a ... L01CE03 Etirinotecan pegol L01CE04 Belotecan L01CX01 Trabectedin L01DA01 Dactinomycin L01DB01 Doxorubicin L01DB02 Daunorubicin ... Subgroup L01 is part of the anatomical group L Antineoplastic and immunomodulating agents. Codes for veterinary use (ATCvet ... L01XX70 Axicabtagene ciloleucel L01XX71 Tisagenlecleucel QL01XX91 Tigilanol tiglate L01XY01 Cytarabine and daunorubicin L01XY02 ...
... a daunorubicin derivative) Idarubicin is able to pass through cell membranes easier than daunorubicin and doxorubicin because ... Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent". Pharmacotherapy. 4 (2): 61-73. ... Di Marco, A.; Cassinelli, G.; Arcamone, F. (1981). "The discovery of daunorubicin". Cancer Treatment Reports. 65 Suppl 4: 3-8. ... Currently, there are four main anthracyclines in medical use: Doxorubicin Daunorubicin (doxorubicin precursor) Epirubicin (a ...
Antineoplastic drugs may also increase the risk of learning disabilities among children of health care workers who are exposed ... Among the anthracyclines, doxorubicin and daunorubicin were the first, and were obtained from the bacterium Streptomyces ... In the 1970s, antineoplastic (chemotherapy) drugs were identified as hazardous, and the American Society of Health-System ... A written policy needs to be in place in case of a spill of antineoplastic products. The policy should address the possibility ...
8 Immunomodulators and antineoplastics *8.1 Immunomodulators for non-malignant disease. *8.2 Antineoplastics and supportive ... Immunomodulators and antineoplastics[edit]. Immunomodulators for non-malignant disease[edit]. *Adalimumabα[note 59] ...
Antineoplastic+Antimetabolites at the US National Library of Medicine Medical Subject Headings (MeSH) "How Chemotherapy Drugs ... Examples of anthracyclines include: Daunorubicin Doxorubicin (Adriamycin®) Epirubicin Idarubicin Anti-tumor antibiotics that ...
For certain therapy areas, such as antimicrobials, antineoplastics, antihypertensive and anti-inflammatory drugs, the numbers ... Anthracyclines (Aclarubicin · Daunorubicin · Doxorubicin · Epirubicin · Idarubicin · Amrubicin · Pirarubicin · Valrubicin · ...
... antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - antiretroviral therapy - antisense c-fos - ... daunorubicin - DCIS - de novo - death cap - debulking operation - decitabine - decortication - deferoxamine - defibrotide - ...
Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. Several classification ... Among the anthracyclines, doxorubicin and daunorubicin were the first, and were obtained from the bacterium Streptomyces ... The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs.[ ... Antineoplastic Agents in Encyclopedia of Molecular Pharmacology, 2nd Edition, Volume 1. Eds. Offermanns S and Rosenthal W. ...
Antineoplastic+Antimetabolites at the US National Library of Medicine Medical Subject Headings (MeSH) ... Daunorubicin. *Doxorubicin (Adriamycin®). *Epirubicin. *Idarubicin. Anti-tumor antibiotics that are not anthracyclines include: ...
Examples include doxorubicin (adriamycin) and daunorubicin (both of which are used in treatment of Hodgkin's lymphoma), and ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.. *v ...
Another amino acid-like drug is the antineoplastic agent melphalan. Tumor cells spend less time in resting phases than normal ...
... is in the platinum-based antineoplastic family of medications.[4] It is believed to work by blocking the ...
Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Alkylating antineoplastic agent. References[edit]. *^ a b c d e f g h "Dacarbazine". The American Society of Health-System ...
... have shown superior antiproliferative activity to rapalogs and in vivo models have confirmed these potent antineoplastic ...
Both in vitro and in vivo analysis show the anti-neoplastic activity of docetaxel to be effective against a wide range of known ... cancer cells, cooperate with other anti-neoplastic agents activity, and have greater cytotoxicity than paclitaxel, possibly due ...
Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Antineoplastic AgentsCancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect this growth. ... Daunorubicin (Cerubidine). Daunorubicin is an anthracycline that intercalates with DNA and interferes with DNA synthesis. ... Antineoplastic Agents. Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect this growth. ... Antineoplastic agents interfere with cell reproduction. Some agents act at specific phases of the cell cycle, whereas others ( ...
Daunorubicin is an anthracycline. Its multiple mechanisms of action involve DNA intercalation, topoisomerase-mediated DNA ... Antineoplastics, Other. Class Summary. Cancer chemotherapy is based on an understanding of tumoral cell growth and on how drugs ... Antineoplastic agents interfere with cell reproduction. Some agents are cell cycle specific, whereas others (eg, alkylating ... Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. ...
... has parent hydride tetracene (CHEBI:32600) daunorubicin (CHEBI:41977) has role antineoplastic agent ... daunorubicin (CHEBI:41977) is a tetracenequinones (CHEBI:51286) daunorubicin (CHEBI:41977) is conjugate base of daunorubicin(1+ ... daunorubicin (CHEBI:41977) has role bacterial metabolite (CHEBI:76969) daunorubicin (CHEBI:41977) is a p-quinones (CHEBI:25830 ... daunorubicin (CHEBI:41977) is a aminoglycoside antibiotic (CHEBI:22507) daunorubicin (CHEBI:41977) is a anthracycline (CHEBI: ...
Professional guide for Daunorubicin and Cytarabine (Liposomal). Includes: pharmacology, pharmacokinetics, contraindications, ... Antineoplastic Agent, Topoisomerase II Inhibitor. Pharmacology. Daunorubicin and cytarabine (liposomal) is a combination ... Daunorubicin and cytarabine liposome Intravenous (Advanced Reading). Professional resources. *DAUNOrubicin and Cytarabine (AHFS ... Formulations: [US Boxed Warning]: Daunorubicin/cytarabine (liposomal) has different dosage recommendations than daunorubicin ( ...
Daunorubicin. Idarubicin. Antimetabolites, Antineoplastic. Antimetabolites. Molecular Mechanisms of Pharmacological Action. ... Drug Information available for: Cytarabine Daunorubicin Daunorubicin hydrochloride Idarubicin hydrochloride Idarubicin ... Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients ... Antineoplastic Agents. Antiviral Agents. Anti-Infective Agents. Immunosuppressive Agents. Immunologic Factors. Physiological ...
Daunorubicin. Molecular Mechanisms of Pharmacological Action. Antibiotics, Antineoplastic. Antineoplastic Agents. Topoisomerase ... Drug Information available for: Daunorubicin Daunorubicin hydrochloride Genetic and Rare Diseases Information Center resources ... daunorubicin =, 65 mg/m^2 daily x 3 days, or idarubicin 12 mg/m^2 daily x 3 days); patients beginning liposomal Daunorubicin on ... Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy. The ...
At least 4 weeks since prior antineoplastic treatment for KS, including any of the following:. *Chemotherapy (6 weeks for ... Drug Information available for: Sodium citrate Daunorubicin Daunorubicin hydrochloride Genetic and Rare Diseases Information ... Patients receive liposomal daunorubicin citrate IV days 1 and 15. Treatment repeats every 4 weeks for at least 3 courses in the ... Liposomal Daunorubicin in Treating Patients With HIV-Related Kaposis Sarcoma. This study has been terminated. ...
Easy to read patient leaflet for Daunorubicin and Cytarabine (Liposomal). Includes indications, proper use, special ... Drug class: antineoplastic combinations. Consumer resources. *Cytarabine and daunorubicin liposomal. Other brands: Vyxeos ... Daunorubicin and Cytarabine (Liposomal). Generic Name: Daunorubicin and Cytarabine (Liposomal) (daw noe ROO bi sin & sye TARE a ... What do I need to tell my doctor BEFORE I take Daunorubicin and Cytarabine?. *If you have an allergy to daunorubicin and ...
Daunorubicin. Antimetabolites, Antineoplastic. Antimetabolites. Molecular Mechanisms of Pharmacological Action. Antineoplastic ... Drug Information available for: Cytarabine Daunorubicin Daunorubicin hydrochloride Venetoclax Genetic and Rare Diseases ... Liposome-encapsulated Daunorubicin-Cytarabine and Venetoclax in Treating Participants With Relapsed, Refractory or Untreated ... Drugs used in chemotherapy, such as liposome-encapsulated daunorubicin-cytarabine and venetoclax, work in different ways to ...
Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the ... caesius in the 1960s and named doxorubicin (DOX) and daunorubicin (DNR) [7]. They still remain one of the most effective ... A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin. Zbynek Heger 1, Natalia Cernei 1,2, Jiri Kudr 1, ... Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the ...
... daunorubicin resistance phenotype involves drug sequestration within intracellular vesicles identified as Golgi vesicles and ... Antibiotics, Antineoplastic / metabolism* * Apoptosis * Cytoplasm / metabolism* * Daunorubicin / metabolism* * Drug Resistance ... Daunorubicin sequestration was investigated through organelle markers (lysosomes, endoplasmic reticulum and Golgi apparatus) ... Conclusions: In addition to P-glycoprotein mediated drug efflux and without MRP overexpression, MCF-7(DXR) daunorubicin ...
Antibiotics, Antineoplastic / pharmacology* * Apoptosis* * Cell Division / drug effects * Cyclosporins / pharmacology* * ... Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P- ... of combinations of suboptimal concentrations of Pgp blockers on the induction of apoptosis and growth arrest in daunorubicin (D ...
0 (Antibiotics, Antineoplastic); 0 (NGR peptide); 0 (Oligopeptides); ZS7284E0ZP (Daunorubicin). [Em] M s de entrada:. 1709. ... 5J49Q6B70F (Vincristine); EC 3.5.1.1 (Asparaginase); VB0R961HZT (Prednisone); ZS7284E0ZP (Daunorubicin). [Em] M s de entrada:. ... Purpose We compared two induction regimens, idarubicin (12 mg/m /d for 3 days) versus high-dose daunorubicin (90 mg/m /d for 3 ... 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Kelch-Like ECH-Associated Protein 1); 0 (NF-E2-Related Factor 2); 04079A1RDZ ( ...
0/Antineoplastic Agents, Alkylating; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin; 302-79-4/Tretinoin; 50-44-2/6-Mercaptopurine ... Antineoplastic Agents, Alkylating / administration & dosage, adverse effects. Antineoplastic Combined Chemotherapy Protocols / ... Daunorubicin / administration & dosage, adverse effects. Drug Synergism. Fatal Outcome. Humans. Leukemia, Myeloid, Acute / drug ...
Study Exam III Antineoplastic flashcards from Sel M ... 3) **daunorubicin citrate (DaunoXome). 4) dactinomycin ( ... MOST ANTINEOPLASTIC DRUGS TARGET DIVIDING CELLS -SMALL RAPIDLY DIVIDING CELLS RESPOND BEST TO CHEMO. -NORMAL CELLS ALSO RAPIDLY ... 5) daunorubicin hydrochloride (Cerubidine). 6)mitoxantrone(Novantrone). 7)mitomycin (Mutamycin). 8) **thalidomide (Thalomid). ...
... anthracenedione antineoplastic agents, such as mitoxantrone; anthracyclines, such dactinomycin, daunorubicin, doxorubicin, ... Such agents include, for example, alkylating antineoplastic agents, such as cisplatin, carboplatin, oxaliplatin, ...
... Antineoplastics (or antitumor antibiotics, or noncovalent DNA-binding drugs, or cytotoxic antibiotics, see ... Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin) - streptomyces (Actinomycin ... Chemotherapeutic agents/Antineoplastic agents (L01). Alkylating and alkylating-like agents. Nitrogen mustards: (Chlorambucil, ... Antineoplastics work by: * Inhibiting topoisomerase II, thereby stopping DNA from being unwound, which is required for both DNA ...
... daunorubicin-13C,d3 6,8,11-Triyl Triacetate from toronto research chemicals Inc. ... Antineoplastic.. References. Cassinelli, G., et al.: J. of Antibiotics, XXXI, 3, 179 (1978) ... 4-Acetoxy N-(Trifluoroacetyl)daunorubicin 6,8,11-Triyl Triacetate * 4-Acetoxy N-(Trifluoroacetyl)daunorubicin-13C,d3 6,8,11- ... 4-Acetoxy N-(Trifluoroacetyl)daunorubicin-13C,d3 6,8,11-Triyl Triacetate is an intermediate in the synthesis of Daunorubicin- ...
Fitz- Antineoplastics VI Flashcards Preview IHO Week 4 , Fitz- Antineoplastics VI , Flashcards ...
... antineoplastic) medication. Daunorubicin liposomal interferes with the growth of cancer cells and slows their growth and spread ... Daunorubicin liposomal is used to treat advanced HIV-associated Kaposis sarcoma. Daunorubicin liposomal may also be used for ... What is daunorubicin liposomal?. Daunorubicin liposomal is a cancer (antineoplastic) medication. Daunorubicin liposomal ... How is daunorubicin liposomal given?. Daunorubicin liposomal is injected into a vein through an IV. A healthcare provider will ...
... anthracenedione antineoplastic agents, such as mitoxantrone; anthracyclines, such dactinomycin, daunorubicin, doxorubicin, ... Such agents include, for example, alkylating antineoplastic agents, such as cisplatin, carboplatin, oxaliplatin, ...
... antibiotic natural antineoplastics, such as bleomycin, dactinomycin, daunorubicin, doxorubicin, and mitomycin; vinca alkaloid ... natural antineoplastics, antibiotic natural antineoplastics, and vinca alkaloid natural antineoplastics; autonomic agents, such ... alkylating antineoplastic agents, such as carboplatin and cisplatin; nitrosourea alkylating antineoplastic agents, such as ... pyrimidine analog antimetabolite antineoplastic agents, such as fluorouracil (5-FU) and gemcitabine; hormonal antineoplastics, ...
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. ... A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the ...
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. ... A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the ... Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to ...
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. ...
Daunorubicin Idarubicin Doxorubicin Grethe, Guenter; Mitt, Toomas; Williams, Thomas H; Uskokovic, Milan R (1983). "Synthesis of ... Daunosamine is a component of the anthracycline class of antineoplastics, linked to a derivative of naphthacene. It is a ... peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin ...
Daunorubicin Liposomal (DaunoXome) chemotherapy side effects, how its given, how it works, precautions and self care tips for ... Drug type: Daunorubicin (liposomal) is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is ... How Daunorubicin (liposomal) Is Given:. *Daunorubicin (liposomal) is given into a vein as an infusion over 1 hour. ... What Daunorubicin (liposomal) Is Used For:. *Daunorubicin (liposomal) is used as first-line therapy against advanced Kaposis ...
... daunorubicin, bleomycin and hydroxycarbamide; anticoagulants, such as heparin, heparinoids, coumaerins, detran and indandiones ... antineoplastic agents, such as doxorubicin, cyclophosphamide, chlormethine, methotrexate, fluorouracil, vincristine, ...
  • Antineoplastics (or "antitumor antibiotics", or "noncovalent DNA-binding drugs", or "cytotoxic antibiotics", see also neoplastics) are drugs that inhibit and combat the development of tumors . (bionity.com)
  • The antineoplastic antibiotics are products of Streptomyces . (merckvetmanual.com)
  • The anthracycline antibiotics, particularly doxorubicin , have become important antineoplastic antibiotics. (merckvetmanual.com)
  • Daunorubicin (DNM) and other anthracycline antibiotics are among the most active agents in the cytostatic chemotherapy of acute leukemias and are widely used in clinical oncology. (springer.com)
  • Doxorubicin, epirubicin, idarubicin and valrubicin are structurally related cytotoxic antineoplastic antibiotics used in the therapy of several forms of lymphoma, leukemia, sarcoma and solid organ cancers. (nih.gov)
  • This randomized phase III trial studies cytarabine and daunorubicin hydrochloride or idarubicin and cytarabine with or without vorinostat to see how well they work in treating younger patients with previously untreated acute myeloid leukemia. (clinicaltrials.gov)
  • Drugs used in chemotherapy, such as cytarabine, daunorubicin hydrochloride, idarubicin, and vorinostat, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping from spreading. (clinicaltrials.gov)
  • Thus, it inhibits the lesions induced by subcutaneous (s.c.) daunorubicin, idarubicin, and doxorubicin in mice and has proven to be successful clinically as well. (uptodate.com)
  • Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. (nextbio.com)
  • Clinically the most widely used are doxorubicin, daunorubicin and their semi-synthetic derivatives epirubicin and idarubicin. (wikiversity.org)
  • Lotfi K, Zackrisson AL, Peterson C (2002) Comparison of idarubicin and daunorubicin regarding intracellular uptake, induction of apoptosis, and resistance. (springer.com)
  • such as daunorubicin hydrochloride, daunomycin or rubidomycin when referring to the generic drug name daunorubicin. (chemocare.com)
  • 5 . The process of claim 4 , wherein the antineoplastic agent is selected from the group consisting of Doxorubicin hydrochloride, Daunorubicin hydrochloride, and Epirubicin hydrochloride. (google.it)
  • 6 . The process of claim 5 , wherein the antineoplastic agent is Doxorubicin hydrochloride. (google.it)
  • 21 . The liposome of claim 20 , wherein the antineoplastic agent is Doxorubicin hydrochloride. (google.it)
  • Here, we report that the antineoplastic agents, daunorubicin hydrochloride, etoposide, and vincristine sulfate inhibited the ability of 1,25(OH) 2 D 3 to cause the accumulation of mRNA for kidney 25-hydroxyvitamin D 3 24-hydroxylase (CYP24), an enzyme which catabolizes this hormone. (aacrjournals.org)
  • Our data show that daunorubicin hydrochloride, etoposide, and vincristine sulfate, three well-characterized antineoplastic agents, caused the accumulation of 1,25(OH) 2 D 3 in kidney cells. (aacrjournals.org)
  • The hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. (unt.edu)
  • Epirubicin (Ellence) hydrochloride is a synthetic derivative of daunorubicin (DaunoXome), the prototype anthracycline. (cancernetwork.com)
  • Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. (nanoshel.com)
  • DAUNOrubicin hydrochloride is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51198/all/DAUNOrubicin_hydrochloride. (unboundmedicine.com)
  • www.drugguide.com/ddo/view/Davis-Drug-Guide/51198/all/DAUNOrubicin_hydrochloride. (drugguide.com)
  • CONCLUSIONS: Dexrazoxane is extremely effective and apparently quite specific in protecting against lesions after s.c. doxorubicin and daunorubicin. (uptodate.com)
  • Includes the antineoplastic drugs doxorubicin and daunorubicin. (thefreedictionary.com)
  • The antineoplastic drugs doxorubicin and daunorubicin also induced significant enlargement of cardiomyocytes at 10 to 100 nM dose range. (aspetjournals.org)
  • Anthracyclines are a clinically important class of antineoplastic agents used to treat a wide variety of solid and blood cancers. (wikiversity.org)
  • In this construct, daunorubicin is used as a model drug, while all anthracyclines could be loaded into the liposomes with the same procedures. (springer.com)
  • 4'-Acetoxy N-(Trifluoroacetyl)daunorubicin-13C,d3 6,8,11-Triyl Triacetate is an intermediate in the synthesis of Daunorubicin-13C,d3 (D194502), an anthracycline antibiotic related to the rhodomycins. (trc-canada.com)
  • Antineoplastic antibiotic obtained from Streptomyces peucetius. (bioportfolio.com)
  • An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. (fpnotebook.com)
  • anthracycline antibiotic produced by Streptomyces coeruleorubidus or Streptomyces peucetius and used as an antineoplastic. (fpnotebook.com)
  • A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding region that functionally mimics the three-dimensional structure of a specific epitope on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic activity. (cancer.gov)
  • Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. (adooq.com)
  • A selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. (unt.edu)
  • A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. (unt.edu)
  • Any of a group of anticancer drugs (daunorubicin, doxorubicin, bleomycin, dactinomycin) which block cell growth by DNA intercalation, blocking synthesis of DNA and RNA. (thefreedictionary.com)
  • Daunorubicin hydochloride and daunomycin are other names for daunorubicin. (chemocare.com)
  • Early concerns about occupational exposure to provides some guidance on engineering controls antineoplastic drugs first appeared in the 1970s. (cdc.gov)
  • You must check to make sure that it is safe for you to take daunorubicin and cytarabine with all of your drugs and health problems. (drugs.com)
  • The adverse health effects associated with antineoplastic agents (cancer chemotherapy drugs, cytotoxic drugs) in cancer patients and some non-cancer patients treated with these drugs are well-documented. (bionity.com)
  • Pharmacists that prepare these drugs or nurses that may prepare and/or administer them are the two occupational groups with the highest potential exposure to antineoplastic agents. (bionity.com)
  • The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs. (bionity.com)
  • Clinical pharmacology is one of the tools to determine and possibly predict antitumor efficacy as well as toxicity of antineoplastic drugs in man. (springer.com)
  • Excerpt: Chemotherapy (sometimes cancer chemotherapy) is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen. (abebooks.de)
  • This class of drugs include doxorubicin (Adriamycin) and daunorubicin. (denvernaturopathic.com)
  • Huwyler J, Drewe J, Krähenbuhl S (2008) Tumor targeting using liposomal antineoplastic drugs. (springer.com)
  • Alkylating agents are non-cell cycle specific antineoplastics drugs. (nursingpath.in)
  • As the cellular pharmacology of cytostatics in tumor cells and organ tissues may better contribute to the understanding of the antineoplastic effect and the toxic side effects of cytostatic chemotherapy and thus may better predict drug resistance individually, attempts are necessary to develop appropriate methods in man in vivo. (springer.com)
  • DaunoXome is the trade name for Daunorubicin. (chemocare.com)
  • In some cases, health care professionals may use the trade name DaunoXome when referring to the generic drug name Daunorubicin. (chemocare.com)
  • DaunoXome is the drug Daunorubicin encapsulated in a closed lipid sphere (liposome). (chemocare.com)
  • Furthermore, 1,25(OH) 2 D 3 and analogues can enhance, either synergistically or additively, the antitumor activities of several classes of antineoplastic agents ( 3 , 4 ). (aacrjournals.org)
  • Since its introduction into clinical practice in the 1960s, doxorubicin has been recognized as one of the most active antineoplastic agents available, with a wide spectrum of antitumor efficacy. (cancernetwork.com)
  • Coadministration of HG-829 fully restored in vivo antitumor activity of daunorubicin in mice without added toxicity. (aacrjournals.org)
  • A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. (fpnotebook.com)
  • The first described anthracycline, daunorubicin, was first isolated from a strain of Streptomyces peucetius in the early 1960s. (wikiversity.org)
  • Traditional antineoplastic therapy is based on the use of chemotherapeutic compounds, which exert a cytotoxic effect on proliferating cells and promote the destruction of sensitive tumors ( 1 ). (jimmunol.org)
  • Antineoplastic agents, sometimes called cancer chemotherapeutic agents, are used clinically to interfere with the neoplastic cells. (pocketdentistry.com)
  • Dactinomycin, used in the treatment of Wilms' tumor, testicular carcinoma, choriocarcinoma, rhabdomyosarcoma, and some other sarcomas, exerts its antineoplastic effect by interfering with ribonucleic acid (RNA) synthesis. (thefreedictionary.com)
  • Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. (adooq.com)
  • Daunorubicin and cytarabine (Vyxeos) is a liposomal combination of an anthracycline topoisomerase inhibitor (daunorubicin) and a nucleoside metabolic inhibitor (cytarabine) in a 1:5 molar ratio. (bcbsnd.com)
  • What are the possible side effects of daunorubicin liposomal? (cigna.com)
  • There are many options to minimize or prevent the side effects of daunorubicin (liposomal). (chemocare.com)
  • Etoposide is classified as an antineoplastic, according ATC index. (farmavita.net)
  • 9,10] The DNA topoisomerases I and II are targets of several antineoplastic agents. (cancernetwork.com)
  • Often, combinations of several antineoplastic agents, used in conjunction with surgery and/or irradiation, may effect a cure that each procedure alone could not. (pocketdentistry.com)
  • Determine the effect of liposomal daunorubicin citrate on Kaposi's sarcoma-associated herpes virus (KSHV) viral gene expression in tumors of patients with HIV-related Kaposi's sarcoma. (clinicaltrials.gov)
  • Patients receive liposomal daunorubicin citrate IV days 1 and 15. (clinicaltrials.gov)
  • On August 3, 2017, a liposome-encapsulated combination of daunorubicin and cytarabine (Vyxeos) was approved for treatment of adults with newly diagnosed therapy-related acute myeloid leukemia (AML) or AML with myelodysplasia-related changes. (ascopost.com)
  • Daunorubicin and cytarabine liposomal (Vyxeos) is considered experimental/investigational for all other indications and therefore, non-covered. (bcbsnd.com)
  • Most people will not experience all of the daunorubicin (liposomal) side effects listed. (chemocare.com)
  • Most people do not experience all of the daunorubicin side effects listed. (chemocare.com)
  • Per animal data, liposomes are taken up intact by bone marrow cells (to a greater degree in leukemia cells versus normal bone marrow cells) and are degraded following cellular internalization, thus releasing cytarabine and daunorubicin within the cells. (drugs.com)
  • After cellular internalization, liposomes undergo degradation, releasing cytarabine and daunorubicin into the intracellular environment. (ascopost.com)
  • Skovsgaard T (1978) Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells. (springer.com)
  • Rubidomycin) is a topoisomerase II inhibitor with potent antineoplastic activities. (adooq.com)
  • The Gamma histone H2AX (γH2AX) assay was used assess the effects of DNA-PK inhibitor NU7026 and RAD51 inhibitor RI-2 on repair of DNA-DSB following treatment with daunorubicin. (edu.au)
  • These four agents are all semisynthetic derivatives of daunorubicin and share activities and toxicities. (nih.gov)
  • The ability of new formamidine sugar-modified derivatives of daunorubicin to stimulate free radical formation in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase. (semanticscholar.org)
  • Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
  • The resistance phenotype of doxorubicin-selected MCF-7(DXR) human breast adenocarcinoma cell line was characterized by cellular and nuclear daunorubicin efflux, P-gp and MRP expression and apoptosis induction. (nih.gov)
  • Although no rational relationship could be established between daunorubicin sequestration and apoptosis induction, no apoptosis was observed in MCF-7(DXR) cells. (nih.gov)
  • In addition to P-glycoprotein mediated drug efflux and without MRP overexpression, MCF-7(DXR) daunorubicin resistance phenotype involves drug sequestration within intracellular vesicles identified as Golgi vesicles and resistance to apoptosis induction. (nih.gov)
  • For this reason, we have investigated the effect of combinations of suboptimal concentrations of Pgp blockers on the induction of apoptosis and growth arrest in daunorubicin (D) treated, MDR1 gene transfected cells. (nih.gov)
  • Tapiero H, Fourcade A, Vaigot P, Farhi JJ (1982) Comparative uptake of adriamycin and daunorubicin in sensitive and resistant Friend leukemia cells measured by flow cytometry. (springer.com)
  • Daunorubicin and cytarabine is a liposomal formulation of daunorubicin and cytarabine at a fixed 1:5 molar ratio. (ascopost.com)
  • This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine and venetoclax work in treating participants with acute myeloid leukemia that has come back, does not respond to treatment, or has not been treated. (clinicaltrials.gov)
  • INDUCTION: Participants receive liposome-encapsulated daunorubicin-cytarabine intravenously (IV) over 90 minutes on days 1, 3, and 5 of course 1 and on days 1 and 3 of course 2. (clinicaltrials.gov)
  • CONSOLIDATION: Participants receive liposome-encapsulated daunorubicin-cytarabine IV over 90 minutes on days 1 and 3 and venetoclax PO QD on days 2-21. (clinicaltrials.gov)
  • Approval was based on improved overall survival with the liposome-encapsulated combination of daunorubicin and cytarabine in an open-label phase III study in which 309 patients aged 60 to 75 years were randomized to receive the liposome-encapsulated combination (n = 153) or a standard (7+3) daunorubicin/cytarabine combination (n = 156). (ascopost.com)
  • The liposome-encapsulated combination of daunorubicin and cytarabine carries warnings/precautions for serious/fatal hemorrhagic events with associated prolonged thrombocytopenia, cardiotoxicity, severe/life-threatening hypersensitivity reactions, local tissue necrosis at the site of drug extravasation, and embryofetal toxicity. (ascopost.com)
  • After cellular internalization, liposomes undergo degradation releasing daunorubicin and cytarabine within the intracellular environment. (bcbsnd.com)
  • Here, the preparation and characterization techniques of dual-targeting daunorubicin liposomes are described. (springer.com)
  • Which medications in the drug class Antineoplastic Agents are used in the treatment of Pediatric Acute Lymphoblastic Leukemia? (medscape.com)
  • The current paucity of literature detailing the overlapping toxicity profiles and pharmacokinetic interactions between HAART and antineoplastic agents as well as the lack of guidelines regarding the optimal pharmacologic regimens for concurrent treatment of HIV and malignancies further complicate therapy. (uspharmacist.com)
  • 2 While the individual toxicities and drug interactions associated with both the antiretroviral and cytotoxic or molecularly targeted antineoplastic drug classes have been extensively studied, there is a clear paucity of literature on their overlapping toxicity profiles and pharmacokinetic inter-actions, not to mention the lack of national guidelines regarding the optimal therapeutic regimens for concurrent treatment of HIV and cancer. (uspharmacist.com)
  • It is a hydroxy derivative of DAUNORUBICIN. (bioportfolio.com)
  • Daunosamine is a component of the anthracycline class of antineoplastics, linked to a derivative of naphthacene. (wikipedia.org)
  • Calculate dose based on the daunorubicin component. (drugs.com)
  • I. Determine the maximum tolerated dose of SU5416 when administered with daunorubicin liposomal in patients with acute myeloid leukemia, refractory anemia with excess blasts (RAEB), RAEB in transformation, or chronic myelomonocytic leukemia not in complete remission 21-50 days after one course of induction chemotherapy. (clinicaltrials.gov)
  • Do not breast-feed while you take daunorubicin and cytarabine and for 2 weeks after your last dose. (drugs.com)
  • Before you receive each dose of daunorubicin liposomal, your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG). (cigna.com)
  • If you have liver disease or any type of liver dysfunction, tell your doctor, to ensure the correct dose of daunorubicin (liposomal) is chosen for you. (chemocare.com)
  • The dose for the first cycle of induction is daunorubicin at 44 mg/m 2 and cytarabine at 100 mg/m 2 liposome via 90-minute infusion on days 1, 3, and 5. (ascopost.com)
  • This article will highlight the most notable pharmacologic concerns regarding the concurrent administration of antiretroviral and antineoplastic agents and provide evidence-based findings regarding agent selection and dose determination. (uspharmacist.com)
  • The recommended dose and dosing schedule of daunorubicin varies widely according to the specific disease being treated, the response to therapy, and the other medications being used. (canada.com)
  • Daunorubicin has antimitotic and cytotoxic activity achieved by forming complexes with DNA, thus inhibiting topoisomerase II activity, inhibiting DNA polymerase activity, affecting the regulation of gene expression, and producing DNA-damaging free radicals. (ascopost.com)
  • Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (fpnotebook.com)
  • Daunorubicin has antimitotic and cytotoxic activity by forming complexes with DNA, inhibiting topoisomerase II activity. (bcbsnd.com)
  • Daunorubicin (conventional) inhibits DNA and RNA synthesis by intercalation between DNA base pairs and by steric obstruction. (drugs.com)
  • Phase I/II trial to study the effectiveness of liposomal daunorubicin and SU5416 in treating patients who have hematologic cancer that has not responded to initial therapy. (clinicaltrials.gov)
  • Patients receive daunorubicin liposomal IV over 6 hours on days 1-3 and SU5416 IV twice a week for 2 months. (clinicaltrials.gov)
  • PURPOSE: This clinical trial is studying how well liposomal daunorubicin works in treating patients with HIV-related Kaposi's sarcoma. (clinicaltrials.gov)
  • As 33% of all HIV-related deaths are attributable to cancer, concomitantly treating such patients with HAART and antineoplastic agents is becoming increasingly common-place. (uspharmacist.com)
  • Daunorubicin is an anthracycline that intercalates with DNA and interferes with DNA synthesis. (medscape.com)
  • Daunorubicin liposomal is a cancer (antineoplastic) medication. (cigna.com)
  • Daunorubicin liposomal may also be used for purposes other than those listed in this medication guide. (cigna.com)
  • Antineoplastic agents interfere with cell reproduction. (medscape.com)
  • The antineoplastic agents interfere with some function of the malignant cells. (pocketdentistry.com)
  • The very nature of antineoplastic agents makes them harmful to healthy cells and tissues, as well as the cancerous cells. (bionity.com)
  • Daunorubicin liposomal can lower blood cells that help your body fight infections and help your blood to clot. (cigna.com)
  • Daunorubicin liposomal interferes with the growth of cancer cells and slows their growth and spread in the body. (cigna.com)
  • Another serious side effect of daunorubicin (liposomal) is that it may lower your body's ability to make blood cells that your body needs. (chemocare.com)
  • Cytarabine is a cell cycle phase-specific antineoplastic agent, affecting cells only during the S-phase of cell division. (bcbsnd.com)
  • Daunorubicin causes the death of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction and growth of cells. (canada.com)
  • As well as interfering with the genetic material DNA of cancer cells, daunorubicin can interfere with some of your normal cells. (canada.com)
  • Daunorubicin (liposomal) is used as first-line therapy against advanced Kaposi's sarcoma associated with HIV. (chemocare.com)
  • Daunorubicin (liposomal) side effects will improve after therapy is complete. (chemocare.com)
  • Daunorubicin aide effects will improve after therapy is complete. (chemocare.com)
  • Studies of gene expression may make it possible to identify biomarkers that will help predict clinical response to antineoplastic drug therapy. (aacrjournals.org)
  • Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. (mdpi.com)
  • Daunorubicin (liposomal) is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
  • The amount of daunorubicin (liposomal) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. (chemocare.com)
  • Daunorubicin is used alone or in combination with other antineoplastic medications for the treatment of many types of cancer including cancers of the blood (e.g., leukemia), lymphosarcoma, reticulosarcoma, Wilm's tumour, and Ewing tumours. (canada.com)
  • These data identify a novel mechanism of action of some commonly used antineoplastic agents which by decreasing the stability of CYP24 mRNA would prolong the bioavailability of 1,25(OH) 2 D 3 for anticancer actions. (aacrjournals.org)
  • Daunorubicin liposomal is used to treat advanced HIV-associated Kaposi's sarcoma. (cigna.com)
  • Chloranil, a reagent in organic chemistry Lawsone, a dye present in the leaves of the henna plant Alizarin, a common red dye DDQ, a reagent in organic chemistry Daunorubicin, an anticancer drug A large scale industrial application of quinones is for the production of hydrogen peroxide. (wikipedia.org)
  • Daunorubicin (DNR), a topoisomerase II (Top II) poison, is a clinically used anticancer agent with a wide spectrum of activity against malignancies. (elsevier.com)
  • Allergic reactions have happened with daunorubicin and cytarabine. (drugs.com)
  • You should not use daunorubicin liposomal if you are allergic to it. (cigna.com)