Antineoplastic agents phytogenic. Medical search

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.

A plant genus of the family LILIACEAE. Members contain ungiminorine and LECTINS.

Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.

Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.

Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

The action of a drug in promoting or enhancing the effectiveness of another drug.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Acridines which are substituted in any position by one or more amino groups or substituted amino groups.

A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).

A cell line derived from cultured tumor cells.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.

Antimetabolites that are useful in cancer chemotherapy.

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Organic compounds that contain 1,2-diphenylethylene as a functional group.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Tumors or cancer of the LUNG.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)

Experimental transplantation of neoplasms in laboratory animals for research purposes.

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Tumors or cancer of the human BREAST.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Elements of limited time intervals, contributing to particular results or situations.

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Established cell cultures that have the potential to propagate indefinitely.

The rate dynamics in chemical or physical systems.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Tumors or cancer of the COLON.

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.

Tumors or cancer of the PROSTATE.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.

A plant genus of the family ASTERACEAE. This plant should not be confused with microtubule asters (MICROTUBULES) nor with aster yellows phytoplasma (mycoplasma-like organisms).

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.

A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Individuals responsible for various duties pertaining to the medical office routine.

A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.

Functions and activities of DENTITION as a whole.

Any materials used in providing care specifically in the hospital.

Clothing designed to protect the individual against possible exposure to known hazards.

The presence of an infectious agent on instruments, prostheses, or other inanimate articles.

An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.

The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.

Inorganic compounds that contain vanadium as an integral part of the molecule.

Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).

Personnel who provide nursing service to patients in a hospital.

The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.

Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

The individuals employed by the hospital.

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)

An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Clinical protocols used to inhibit the growth or spread of NEOPLASMS.

A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.

Facilities for the preparation and dispensing of drugs.

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

Simultaneous resistance to several structurally and functionally distinct drugs.

An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.

The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.

A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.

A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.

Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Institutions with an organized medical staff which provide medical care to patients.

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Compounds that inhibit the activity of DNA TOPOISOMERASE I.

A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.

The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Those persons legally qualified by education and training to engage in the practice of pharmacy.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Keto-pyrans.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.

Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.

Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)

A group of compounds that contain the structure SO2NH2.

DNA present in neoplastic tissue.

A general term for various neoplastic diseases of the lymphoid tissue.

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

An antimitotic agent with immunosuppressive properties.

Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Organic compounds which contain platinum as an integral part of the molecule.

A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.

A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

An alkylating agent of value against both hematologic malignancies and solid tumors.

A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.

The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.

Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.

Institutions specializing in the care of cancer patients.

Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. (1/4985)

Overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, has been observed in tumors from breast cancer patients. We demonstrated previously that emodin, a tyrosine kinase inhibitor, suppresses tyrosine kinase activity in HER-2/neu-overexpressing breast cancer cells and preferentially represses transformation phenotypes of these cells in vitro. In the present study, we examined whether emodin can inhibit the growth of HER-2/neu-overexpressing tumors in mice and whether emodin can sensitize these tumors to paclitaxel, a commonly used chemotherapeutic agent for breast cancer patients. We found that emodin significantly inhibited tumor growth and prolonged survival in mice bearing HER-2/neu-overexpressing human breast cancer cells. Furthermore, the combination of emodin and paclitaxel synergistically inhibited the anchorage-dependent and -independent growth of HER-2/neu-overexpressing breast cancer cells in vitro and synergistically inhibited tumor growth and prolonged survival in athymic mice bearing s.c. xenografts of human tumor cells expressing high levels of p185neu. Both immunohistochemical staining and Western blot analysis showed that emodin decreases tyrosine phosphorylation of HER-2/neu in tumor tissue. Taken together, our results suggest that the tyrosine kinase activity of HER-2/neu is required for tumor growth and chemoresistance and that tyrosine kinase inhibitors such as emodin can inhibit the growth of HER-2/neu-overexpressing tumors in mice and also sensitize these tumors to paclitaxel. The results may have important implications in chemotherapy for HER-2/neu-overexpressing breast tumors. (+info)

CLIP-170 highlights growing microtubule ends in vivo. (2/4985)

A chimera with the green fluorescent protein (GFP) has been constructed to visualize the dynamic properties of the endosome-microtubule linker protein CLIP170 (GFP-CLIP170). GFP-CLIP170 binds in stretches along a subset of microtubule ends. These fluorescent stretches appear to move with the growing tips of microtubules at 0.15-0.4 microm/s, comparable to microtubule elongation in vivo. Analysis of speckles along dynamic GFP-CLIP170 stretches suggests that CLIP170 treadmills on growing microtubule ends, rather than being continuously transported toward these ends. Drugs affecting microtubule dynamics rapidly inhibit movement of GFP-CLIP170 dashes. We propose that GFP-CLIP170 highlights growing microtubule ends by specifically recognizing the structure of a segment of newly polymerized tubulin. (+info)

The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. (3/4985)

Camptothecin is an antitumor agent that kills cells by converting DNA topoisomerase I into a DNA-damaging poison. Although camptothecin derivatives are now being used to treat tumors in a variety of clinical protocols, the cellular factors that influence sensitivity to the drug are only beginning to be understood. We report here that two genes required for sister chromatid cohesion, TRF4 and MCD1/SCC1, are also required to repair camptothecin-mediated damage to DNA. The hypersensitivity to camptothecin in the trf4 mutant does not result from elevated expression of DNA topoisomerase I. We show that Trf4 is a nuclear protein whose expression is cell cycle-regulated at a post-transcriptional level. Suppression of camptothecin hypersensitivity in the trf4 mutant by gene overexpression resulted in the isolation of three genes: another member of the TRF4 gene family, TRF5, and two genes that may influence higher order chromosome structure, ZDS1 and ZDS2. We have isolated and sequenced two human TRF4 family members, hTRF4-1 and hTRF4-2. The hTRF4-1 gene maps to chromosome 5p15, a region of frequent copy number alteration in several tumor types. The evolutionary conservation of TRF4 suggests that it may also influence mammalian cell sensitivity to camptothecin. (+info)

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (4/4985)

A combination chemotherapy of irinotecan (CPT-11) and cisplatin (CDDP) has been reported to be active for lung cancer. In the previous trial, however, diarrhoea and leucopenia became the major obstacle for sufficient dose escalation of CPT-11 to improve the treatment outcome. We conducted a phase I study to investigate whether the fractionated administration of CDDP and CPT-11 at escalated dose was feasible and could improve the treatment outcome. Twenty-four previously untreated patients with unresectable non-small-cell lung cancer (NSCLC) or extensive disease of small-cell lung cancer (SCLC) were eligible. Both CDDP and CPT-11 were given on days 1 and 8, and repeated every 4 weeks. The dose of CDDP was fixed at 60 mg m(-2) and given by 1-h infusion before CPT-11 administration. The starting dose of CPT-11 was 40 mg m(-2), and the dose was escalated by an increase of 10 mg m(-2). The maximally tolerated dose of CPT-11 was determined as 60 mg m(-2) because grade 4 haematological or grade 3 or 4 non-haematological toxicities developed in six patients out of 11 patients evaluated. Diarrhoea became a dose-limiting toxicity. The objective response rates were 76% for NSCLC and 100% for SCLC. The recommended dose of CPT-11 and CDDP in a phase II study will be 50 mg m(-2) and 60 mg m(-2) respectively. (+info)

A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts. (5/4985)

Clinically available taxanes represent one of the most promising class of antitumor agents, despite several problems with their solubility and toxicity. In an attempt to improve the pharmacological profile of taxanes, a new series of analogues was synthesized from 14beta-hydroxy-10-deacetylbaccatin III and tested in a panel of human tumor cell lines. On the basis of the pattern of cytotoxicity and lack of cross-resistance in tumor cell lines expressing the typical multidrug-resistant phenotype, a compound (IDN5109) was selected for preclinical development. A comparative efficacy study of IDN5109 and paclitaxel was performed using a large panel of human tumor xenografts, characterized by intrinsic (seven tumors) or acquired (four tumors) resistance to cisplatin or doxorubicin, including four ovarian, one breast, one cervical, three lung, one colon, and one prostatic carcinoma. Drugs were delivered i.v. according to the same schedule (four times every 4th day). IDN5109 achieved a very high level of activity (percentage tumor weight inhibition >70%; log10 cell kill >1) in all but one of the tested tumors. Compared to paclitaxel, IDN5109 exhibited a significantly superior activity in six tumors (including the four tumors that were resistant to paclitaxel) and a comparable activity against the other five paclitaxel-responsive tumors. Additional advantages of IDN5109 over paclitaxel were also suggested by its toxicity profile. IDN5109 was not only less toxic (maximal tolerated doses were 90 and 54 mg/kg for IDN5109 and paclitaxel, respectively), but it also appeared to be endowed with a reduced neurotoxic potential and an improved profile of tolerability compared to the parent drug. Furthermore, the best antitumor efficacy was often already reached with doses lower than the maximal tolerated dose, suggesting an improved therapeutic index for the new drug. In conclusion, the results support the preclinical interest of IDN5109 in terms of the toxicity profile and of the efficacy with particular reference to the ability to overcome multiple mechanisms of drug resistance. (+info)

Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. (6/4985)

6-Hydroxymethylacylfulvene (MGI-114) is a semisynthetic analogue of the toxin illudin S, a product of the Omphalotus mushroom. MGI-114 induces cytotoxicity in a variety of solid tumors in vivo, including the refractory HT29 human colon cancer xenograft. In this study, the potential application of MGI-114 in the treatment of colon cancer was further explored by evaluating the activity of MGI-114 in combination with irinotecan (CPT-11) and 5-fluorouracil (5FU). Groups of 9 nude mice bearing HT29 xenografts were treated with either single agent MGI-114, CPT-11, or 5FU, or MGI-114 in combination with CPT-11 or 5FU. MGI-114 was administered at doses of 3.5 and 7 mg/kg i.p. daily on days 1 through 5, and CPT-11 and 5FU were administered at doses of 50 and 100 mg/kg i.p. on days 1, 12, and 19. In the single agent studies, MGI-114, CPT-11, and 5FU all resulted in decreased final tumor weights compared with vehicle-treated controls (P<0.05), but only MGI-114 at 7 mg/kg produced partial responses. When MGI-114 at 3.5 mg/kg was combined with CPT-11, significant decrements in final tumor weights occurred compared with monotherapy with the same doses of MGI-114 and CPT-11 (P< or =0.001). Also, administration of the low-dose combination (MGI-114 at 35 mg/kg and CPT-11 at 50 mg/kg) resulted in final tumor weights similar to those achieved after administration of high-dose MGI-114 as a single agent. Moreover, the combination of MGI-114 and CPT-11 produced partial responses in nearly all of the animals, with some animals achieving complete responses. The outcome with the combination of MGI-114 and 5FU was less striking, with fewer partial responses and no complete responses. These results suggest enhanced activity when MGI-114 is combined with CPT-11, and clinical trials to further evaluate this combination regimen are planned. (+info)

Cyclosporine inhibited calcium-mediated apoptosis of HL-60 cells. (7/4985)

AIM: To study the effects of cyclosporine (Cyc) on apoptosis of HL-60 cells. METHODS: Apoptotic cells induced by harringtonine (Har), camptothecin (Cam), or calcimycin (Cal), thapsigargin (Tha) were identified with DNA electrophoresis, morphology, and flow cytometry. Relative [Ca2+]i alteration of apoptotic HL-60 cells were determined with flow cytometry. RESULTS: Cal 1 mg.L-1 or Tha 0.5 mg.L-1 induced apoptosis of HL-60 cells. This effect was inhibited by nontoxic concentration of Cyc 1 mg.L-1. Cyc did not inhibit Har- or Cam-induced apoptosis of HL-60 cells. Both Cal and Tha increased intracellular calcium, whereas Har or Cam did not. CONCLUSION: Cyc inhibited apoptosis only induced by calcium increasement in HL-60 cells. The mechanism of apoptosis induced by Cal or Tha was different from that by Har or Cam. (+info)

Quercetin induced apoptosis in human leukemia HL-60 cells. (8/4985)

AIM: To examine whether quercetin (Que) might induce apoptosis in human leukemia HL-60 cells. METHODS: DNA fragmentation was visualized by agarose gel electrophoresis. Inhibition of proliferation was measured with a colorimetric MTT-assay. The DNA degradation was determined using flow cytometry, and the microscopic changes were observed by an electron microscope. RESULTS: Que 15-120 mumol.L-1 elicited typical apoptosis morphological changes including condensed chromatin, nuclear fragmentation, and reduction in volume. DNA fragmentation and DNA degradation in a concentration-dependent manner in HL-60 cells. Que inhibited HL-60 cell proliferation. The values of IC50 and 95% confidence limits were 43 (30-61) mumol.L-1 after 48-h treatment with Que. CONCLUSION: Que induced apoptosis in HL-60 cells. (+info)

... antineoplastic agents, hormonal MeSH D27.505.954.248.179 - antineoplastic agents, phytogenic MeSH D27.505.954.248.589 - ... antineoplastic MeSH D27.505.954.248.147 - antimitotic agents MeSH D27.505.954.248.150 - antineoplastic agents, alkylating MeSH ... MeSH D27.505.519.124 - alkylating agents MeSH D27.505.519.124.035 - antineoplastic agents, alkylating MeSH D27.505.519.155 - ... lipotropic agents MeSH D27.505.954.248 - antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)

Antineoplastic Agents, Phytogenic / chemistry * Antineoplastic Agents, Phytogenic / isolation & purification * Antineoplastic ... Background: The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop ... and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the ...

https://pubmed.ncbi.nlm.nih.gov/33342418/

Antineoplastic Agents, Phytogenic / chemistry * Antineoplastic Agents, Phytogenic / isolation & purification * Antineoplastic ...

https://pubmed.ncbi.nlm.nih.gov/27180878/

Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ...

https://clinicaltrials.gov/ct2/show/NCT00004054

Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ... Antineoplastic Agents, Immunological. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological ...

https://www.clinicaltrials.gov/show/NCT03169335

Organic Compound; Amine; Ether; Ester; Drug; Antineoplastic Agent, Phytogenic; Tubulin Modulator; Metabolite; Synthetic ...

http://www.chemspider.com/Chemical-Structure.211446.html

Antineoplastic Agents, Phytogenic. Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E. 2017. The ... Anticarcinogenic Agents. Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, E Houseman A, Williams DE, Dashwood RH, Ho ...

https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=3151&o=desc&page=6&s=keyword

Antineoplastic Agents, Phytogenic. Registry Number. 214UUQ9N0H. Related Numbers. 29883-15-6. CAS Type 1 Name. ...

https://meshb.nlm.nih.gov/record/ui?ui=D000678

Antimutagenic Agents. *. Antineoplastic Agents. *. Antineoplastic Agents, Phytogenic. *. Flavoring Agents. *. Food Additives. * ... A flavoring agent; an antimutagen but recent studies showed that high doses of cinnamaldehyde in the liver may produce a ...

https://chem.nlm.nih.gov/chemidplus/rn/14371-10-9

Antineoplastic Agents, Phytogenic. Registry Number:. 214UUQ9N0H CAS Type 1 Name:. Benzeneacetonitrile, alpha-((6-O-beta-D- ...

https://decs.bvsalud.org/en/ths/resource/?id=692

1 Antineoplastic Agents, Phytogenic.... *1 Apoptosis --drug effects. *1 Betulinic acid. *1 Breast cancer ...

https://imsear.searo.who.int/handle/123456789/1368/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=subject&filter_type_1=equals&filter_value_1=Mice&filter_field_2=subject&filter_type_2=equals&filter_value_2=Humans&filter_field_3=subject&filter_type_3=equals&filter_value_3=Mice%2C+Inbred+BALB+C&etal=0&filtername=author&filterquery=Narkar%2C+Archana+A&filtertype=equals

"Antineoplastic Agents, Phytogenic", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": " ... Antineoplastic Agents, Phytogenic 181. ″ rdf:type schema:DefinedTerm 182. Nedb86e5849f14655b337c12a550cb7db rdf:first sg:person ...

https://scigraph.springernature.com/pub.10.1038/sj.onc.1202716

Antineoplastic Agents, Phytogenic. Brain. Central Nervous System. Chromatography, High Pressure Liquid. Female. Ganglia, Spinal ... within the central and peripheral nervous system after repeated administration of this antineoplastic agent is still largely ... within the central and peripheral nervous system after repeated administration of this antineoplastic agent is still largely ...

https://iris.hunimed.eu/handle/11699/68563

... antineoplastic agents, phytogenic; cohort analysis; lung cancer; dose-response relationship, drug; breast neoplasms; ... antineoplastic agents, alkylating; brain metastasis; muscle weakness; seizure; headache; maximum tolerated dose; phase 1 ... a lipophilic large-spectrum agent, in an attempt to improve the efficacy of TMZ. This phase I study was conducted to establish ... antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; peripheral neuropathy; drug ...

https://synapse.mskcc.org/synapse/works/27804

Anti-Bacterial AgentsAntineoplastic Agents, PhytogenicCandida albicansCell ProliferationCubaDrug Screening Assays, Antitumor ...

https://www.unboundmedicine.com/medline/citation/26917060/The_Chemical_Diversity_of_Lantana_camara:_Analyses_of_Essential_Oil_Samples_from_Cuba_Nepal_and_Yemen_

Antimitotic Agents. *Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. *Mitosis Modulators. *Tubulin Modulators. ... This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell ... NCI: A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin ...

https://druginfo.nlm.nih.gov/m.drugportal/rn/33069-62-4

Antineoplastic Agents, Phytogenic. Cardenolides. Papers overview. Semantic Scholar uses AI to extract papers important to this ...

https://www.semanticscholar.org/topic/tupichinolide/3146865

Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and ... Antineoplastic Agents, Phytogenic, Antineoplastic Combined Chemotherapy Protocols, Treatment Outcome, Drug Administration ... Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and ...

https://www.well.ox.ac.uk/publications/1212590

Antineoplastic Agents, Phytogenic. *Carbon Isotopes. *Magnetic Resonance Spectroscopy. *Plasmodium falciparum. *Protozoan ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Drug%20Resistance,%20Multiple,%20Fungal

Antineoplastic Agents, Phytogenic - therapeutic use Cathepsin B - metabolism Cyclophosphamide - therapeutic use Cysteine ... Abortifacient Agents, Steroidal Carboprost - administration & dosage Contraceptives, Oral, Synthetic Drug Synergism Female ... has additive effects as an ocular hypotensive agent with timolol, a beta-adrenergic antagonist, even though both drugs are ...

https://arctichealth.org/en/list?q=topic%3A%22Drug+Synergism%22&p=1&ps=&sort=title_sort+asc

OR management OR treatment OR antineoplastic* OR preparation* OR terapia* OR tratamento*)) OR ti:herbal* OR "phytogenic agents ... "antineoplastic agents" OR cancer OR analgesic OR antihelminthic)) OR "chitosan weight loss" OR (("thymus extract" OR " ... medicinal OR therapy OR antifungal OR antineoplastic)) OR "medicinal fungi" OR "purple sweet potato anthocyanin" OR ephedra OR ...

https://bvsalud.org/queries/search_strategy/medicinas-tradicionais-complementares-e-integrativas/

Anticarcinogenic Agents. *NAD(P)H Dehydrogenase (Quinone). *Antineoplastic Agents. *Antineoplastic Agents, Phytogenic ...

https://profiles.umassmed.edu/display/127445

Journal Article 2016; 37(Suppl 1): 95-102 PubMed PMID: 28263536 Keywords: Antineoplastic Agents, Phytogenic:metabolism, ... OBJECTIVES: Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest ...

https://www.nel.edu/stiborova-5492/

Anti-Inflammatory Agents. *Antimetabolites, Antineoplastic. *Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. * ...

https://profiles.ucdenver.edu/display/224566/Network/ResearchAreas

Antineoplastic Agents, Phytogenic * Cell Line, Tumor * Cell Movement * Cullin Proteins * Developmental Biology ...

https://scholars.duke.edu/display/pub1145146

Werner syndrome, breast cancer, camptothecin, helicase, topoisomerase I, Antineoplastic Agents, Phytogenic, Apoptosis, Breast ...

https://www.imm.ox.ac.uk/publications/1306690

Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. *Antineoplastic Combined Chemotherapy Protocols. *Anus Neoplasms. * ...

https://uams-triprofiles.uams.edu/profiles/display/127925/network/researchareas/cloud

... phytogenic - isolation & purification ; Antineoplastic agents, phytogenic - pharmacology ; Antineoplastic agents, phytogenic - ... Antineoplastic agents, phytogenic - pharmacology ; Cell line, tumor ; Collagen - biosynthesis ; Dipeptidases - antagonists & ... Photosensitizing agents - therapeutic use ; Psoriasis - blood ; Psoriasis - drug therapy ; Psoriasis - pathology ; Psoriasis - ...

http://biblioteka.amb.edu.pl/cgi-bin/expertus.cgi?KAT=%2Fhome%2Fexpertus%2Fpar%2Fp%2F&FST=data.fst&FDT=data.fdt&ekran=ISO&lnkmsk=2&cond=AND&mask=2&F_00=09&V_00=Down-regulation+

Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. *Antioxidants. *Benzopyrans. *Bile and Liver Therapy. *Biological ...

https://go.drugbank.com/drugs/DB09298

Apoptosis Paclitaxel Nausea Effects Activity High Substances Drugs MeSH Therapeutic Anticancer agent Clinically Toxicity Profiles Therapy Dose Cell

This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (nih.gov)

The distribution of paclitaxel (Taxol) within the central and peripheral nervous system after repeated administration of this antineoplastic agent is still largely unknown. (hunimed.eu)
Paclitaxel and etoposide are two chemotherapy agents with broad cytotoxic activity and different mechanisms of action and resistance. (ox.ac.uk)

International(NANDA-I)in1999(4)anditwentthroughrevisionsinthesubsequenteditionsthatresultedin changesinitsdefinition,aswel as,itsdefiningcharacteristicsandinthefactorsrelatedtoit(5-7).Withinits editionsthatpresentednausearelatedchanges,theNANDA-Iof2007and2008(6)broughtalargerquantity of reviews and almost al diagnoses presented few changes in its defining characteristics and in factors relatedtoitor,ofriskfactors.Itwasinthiseditionthatitwasobservedtheremovalof"chemotherapeutic agents"fromthenusingdiagnosis"nausea",whichisstil absentinthecurrentedition(7). (bvsalud.org)

CONCLUSIONS: Dorzolamide, a carbonic anhydrase inhibitor, has additive effects as an ocular hypotensive agent with timolol, a beta-adrenergic antagonist, even though both drugs are suppressors of aqueous humor flow. (arctichealth.org)

NCI: A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. (nih.gov)

The agent demonstrated sub-nanomolar EC50 binding concentrations, with high specificity and binding could be inhibited by GLP-1R agonists. (perkinelmer.com)

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (uams.edu)

This study is exploring a new combination of drugs fosbretabulin, a vascular disrupting agent and pazopanib, a tyrosine kinase inhibitor. (clinicaltrials.gov)
Both drugs contain the same active agent, but Abraxane is delivered by a nanoparticle technology that binds to albumin, a natural protein, rather than the toxic solvent known as Cremophor. (t3db.ca)
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. (rush.edu)

Antineoplastic Agents, Alkylating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

Although considerable efforts have been made to develop effective therapeutic agents for AD therapy, drug development has not met significant clinical success. (omeka.net)
A considerable effort has been spent investigating the therapeutic potential of antioxidants and anti-inflammatory agents, several of natural products and dietary origin, in AD treatment. (omeka.net)

Paris Saponin II (PSII), a major steroidal saponin extracted from Rhizoma Paris polyphylla, has emerged as a potential anticancer agent. (nih.gov)

Drug interactions are quite common with these agents, some of which are sequence-dependent and clinically significant. (nih.gov)
PURPOSE: ART and its derivatives, clinically used antimalarial agents, have recently shown antitumor activities. (isharonline.org)

Toxicity profiles for these agents are somewhat different. (nih.gov)

Below are the most recent publications written about "Antineoplastic Agents, Alkylating" by people in Profiles. (rush.edu)

The phase 1 protocol will have 2 parts: a single agent dose escalation phase (Part 1) and a combination therapy phase (Part 2). (clinicaltrials.gov)

Both agents undergo hepatic metabolism and biliary excretion and require dose adjustment in the setting of liver dysfunction. (nih.gov)

Modified weekly regimen with vinorelbine as a single agent in unresectable non-small cell lung cancer. (ox.ac.uk)

Anatomy8

Organisms6

Diseases15

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes23

Disciplines and Occupations1

Technology, Industry, Agriculture4

Named Groups4

Health Care15

Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. (1/4985)

CLIP-170 highlights growing microtubule ends in vivo. (2/4985)

The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. (3/4985)

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (4/4985)

A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts. (5/4985)

Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model. (6/4985)

Cyclosporine inhibited calcium-mediated apoptosis of HL-60 cells. (7/4985)

Quercetin induced apoptosis in human leukemia HL-60 cells. (8/4985)

Antineoplastic Agents

Antineoplastic Agents, Phytogenic

Leukemia P388

Amaryllidaceae Alkaloids

Narcissus

Ellipticines

Bibenzyls

Doxorubicin

Drug Screening Assays, Antitumor

Antibiotics, Antineoplastic

Thiadiazines

Bryostatins

Antineoplastic Agents, Alkylating

Ancitabine

Neoplasms

Gallium

Depsipeptides

Tumor Cells, Cultured

Cisplatin

Paclitaxel

6-Mercaptopurine

Drug Synergism

Apoptosis

Aminoacridines

Epothilones

Cell Line, Tumor

Cell Survival

Sarcoma 180

Molecular Structure

Lactones

Leukemia L1210

Antimetabolites, Antineoplastic

Daunorubicin

Fluorouracil

Bleomycin

Dose-Response Relationship, Drug

Etoposide

Antineoplastic Combined Chemotherapy Protocols

Drug Resistance, Neoplasm

Prodrugs

Drug Evaluation, Preclinical

Drug Evaluation

Cell Division

Xenograft Model Antitumor Assays

Drug Resistance

Macrolides

Neoplasms, Experimental

Methotrexate

Camptothecin

Stilbenes

Cell Cycle

Mice, Nude

HL-60 Cells

Enzyme Inhibitors

Cell Proliferation

Lung Neoplasms

Drug Administration Schedule

Vincristine

Isoquinolines

Neoplasm Transplantation

Biotransformation

Drug Interactions

Breast Neoplasms

DNA Damage

Cyclophosphamide

Stereoisomerism

Time Factors

Clinical Trials as Topic

Leukemia

Cell Line

Kinetics

Ovarian Neoplasms

Colonic Neoplasms

Caspases

Taxoids

Prostatic Neoplasms

Structure-Activity Relationship

DNA

Phospholipid Ethers

RNA, Messenger