Substances that inhibit or prevent the proliferation of NEOPLASMS.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.
A plant genus of the family LILIACEAE. Members contain ungiminorine and LECTINS.
Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.
Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
The action of a drug in promoting or enhancing the effectiveness of another drug.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Acridines which are substituted in any position by one or more amino groups or substituted amino groups.
A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).
A cell line derived from cultured tumor cells.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
Antimetabolites that are useful in cancer chemotherapy.
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Organic compounds that contain 1,2-diphenylethylene as a functional group.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Tumors or cancer of the LUNG.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Tumors or cancer of the human BREAST.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Elements of limited time intervals, contributing to particular results or situations.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Established cell cultures that have the potential to propagate indefinitely.
The rate dynamics in chemical or physical systems.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the COLON.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
Tumors or cancer of the PROSTATE.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.
A plant genus of the family ASTERACEAE. This plant should not be confused with microtubule asters (MICROTUBULES) nor with aster yellows phytoplasma (mycoplasma-like organisms).
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Individuals responsible for various duties pertaining to the medical office routine.
A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Functions and activities of DENTITION as a whole.
Any materials used in providing care specifically in the hospital.
Clothing designed to protect the individual against possible exposure to known hazards.
The presence of an infectious agent on instruments, prostheses, or other inanimate articles.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.
Inorganic compounds that contain vanadium as an integral part of the molecule.
Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).
Personnel who provide nursing service to patients in a hospital.
The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
The individuals employed by the hospital.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Clinical protocols used to inhibit the growth or spread of NEOPLASMS.
A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
Facilities for the preparation and dispensing of drugs.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
Simultaneous resistance to several structurally and functionally distinct drugs.
An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.
The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Institutions with an organized medical staff which provide medical care to patients.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Compounds that inhibit the activity of DNA TOPOISOMERASE I.
A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Those persons legally qualified by education and training to engage in the practice of pharmacy.
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Keto-pyrans.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of compounds that contain the structure SO2NH2.
DNA present in neoplastic tissue.
A general term for various neoplastic diseases of the lymphoid tissue.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
An antimitotic agent with immunosuppressive properties.
Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
Organic compounds which contain platinum as an integral part of the molecule.
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
An alkylating agent of value against both hematologic malignancies and solid tumors.
A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
Institutions specializing in the care of cancer patients.

Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect. (1/2596)

Interleukin 6 (IL-6) is a multifunctional cytokine. Recent reports suggest that circulating IL-6 secreted from tumour cells plays an important role in cancer-induced cachexia. Medroxyprogesterone acetate (MPA) has been used as an endocrine therapeutic agent for patients with breast cancer. It has been suggested that MPA decreases serum IL-6 levels and preserves the bodyweight of patients with advanced breast cancer. However, the mechanisms of action responsible for the anticachectic effect of MPA have not been elucidated. Therefore, the effects of MPA on IL-6 secretion were studied both in vitro and in vivo using a human breast cancer cell line, KPL-4, which secretes IL-6 into medium and induces cachexia when injected into female nude mice. MPA (10-1000 nM) dose-dependently decreased basal IL-6 secretion into medium, and also suppressed tumour necrosis factor (TNF-alpha)-induced IL-6 secretion. Both basal and TNF-alpha-induced IL-6 mRNA levels were dose-dependently lowered by MPA. Moreover, intramuscular injections of MPA (100 mg kg(-1) twice a week) into nude mice bearing KPL-4 transplanted tumours significantly decreased serum IL-6 levels without affecting tumour growth and preserved the bodyweight of recipient mice. These findings suggest that suppression of IL-6 secretion from tumour cells, at least in part, causes the anticachectic effect of MPA.  (+info)

The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. (2/2596)

Somatostatin and its analogs can inhibit growth in several cell types, in part by interfering with insulin-like growth factor-I (IGF-I) signaling. Our previous studies point to the importance of paracrine and autocrine IGF-I in the support of growth and survival of human multiple myeloma (MM) cell lines. In this report, we have investigated the potential role of a somatostatin analog, octreotide, in regulating growth and/or survival in MM. The results show that all MM cell lines express functional somatostatin receptors (sst). The MM cell lines express the subtypes sst2, sst3, and predominantly sst5 as determined by reverse-transcriptase polymerase chain reaction and fluorescence-activated cell sorter analysis. Octreotide inhibited the growth of both the interleukin-6 (IL-6)-dependent and the IL-6-independent MM cell lines. The effect is mainly cytostatic, resulting in 25% to 45% growth inhibition, and in three of eight of the MM cell lines a weak induction of apoptosis was recorded. Our results also show that octreotide may act as an inducer of apoptosis in primary B-B4(+) plasma cells isolated from bone marrow of MM patients. In conclusion, the results show a novel pathway for growth inhibition of MM cells: the activation of somatostatin receptor signaling.  (+info)

Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance. (3/2596)

Human breast tumors that are initially responsive to tamoxifen (TAM) eventually relapse during treatment. Estrogen receptor (ER) expression and function are often preserved in these tumors, and clinical evidence suggests that this relapse may be related to TAM's known agonistic properties. ER can interact with the activator protein-1 (AP-1) transcription factor complex through protein-protein interactions that are independent of ER DNA binding and, in certain ER-positive cells, this may allow TAM to exert an agonist response on AP-1-regulated genes. We, therefore, assessed both AP-1 DNA binding and the known AP-1 activating enzyme, c-Jun NH2-terminal kinase (JNK), in a panel of 30 ER-positive primary human breast tumors with acquired TAM resistance, as compared to a matched panel of 27 untreated control ER-positive breast tumors and a separate control set of 14 primary tumors, which included 7 ER-positive tumors that were growth-arrested by 3 months of preoperative TAM. AP-1 DNA binding activity was measured from cryopreserved tumor extracts using a labeled oligonucleotide probe containing a consensus AP-1 response element by electrophoretic mobility shift assay. JNK was first extracted from the tumor lysates by incubation over a Sepharose-bound c-Jun(1-89) fusion protein, and its activity was then measured by chemiluminescent Western blot by detection of the phosphorylated product using a phospho-Jun(Ser-63)-specific primary antibody. The set of control ER-positive breast tumors growth arrested by TAM showed no significant difference from untreated control tumors in their AP-1 DNA binding and JNK activities. In contrast, there was a significant (P < 0.001) increase in mean AP-1 DNA binding activity for the panel of ER-positive TAM-resistant (TAM-R) tumors as compared to its matched control panel of untreated tumors. Mean JNK activity in the TAM-R tumors was also significantly higher than that found in the untreated tumors (P = 0.038). Overall, there was no significant correlation between JNK activity and AP-1 DNA binding; however, regression analysis showed that, for any given level of JNK activity, the TAM-R tumors possessed a 3.5-fold increase in AP-1 DNA binding activity as compared to the untreated tumors. These findings indicate that, when compared to untreated ER-positive primary breast tumors, TAM-R tumors demonstrate significantly increased levels of AP-1 DNA binding and JNK activity, consistent with experimental models suggesting that TAM-stimulated ER-positive tumor growth may be mediated by enhanced AP-1 transcriptional activity. These observations support the need for further evaluation of these markers in breast tumors as predictors of TAM resistance.  (+info)

In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector. (4/2596)

Adenoviral vectors, encoding genes for cell surface antigens or receptors, have been used to induce their high level expression on tumor cells in vitro and in vivo. These induced antigens and receptors can then be targeted with radiolabeled antibodies or peptides for potential radiotherapeutic applications. The purpose of this study was to determine a dosing schema of an adenoviral vector encoding the human somatostatin receptor subtype 2 (AdCMVhSSTr2) for achieving the highest tumor localization of [(111)In]-DTPA-D-Phe1-octreotide, which binds to this receptor, in a human ovarian cancer model as a prelude to future therapy studies. AdCMVhSSTr2 was produced and used to induce hSSTr2 on A427 human nonsmall cell lung cancer cells and on SKOV3.ipl human ovarian cancer cells in vitro, as demonstrated by competitive binding assays using [125I]-Tyr1-somatostatin and [(111)In]-DTPA-D-Phe1-octreotide. Mice bearing i.p. SKOV3.ip1 tumors administered 1 x 10(9) plaque-forming units of AdCMVhSSTr2 i.p. 5 days after tumor cell inoculation, followed by an i.p. injection of [(111)In]-DTPA-D-Phe1-octreotide 2 days later, showed a range of 15.3-60.4% median injected dose/gram (ID/g) in tumor at 4 h after injection compared with 3.5% ID/g when [125I]-Tyr1-somatostatin was administered and 0.3% ID/g when the negative control peptide [125I]-mIP-bombesin was administered. Mice administered a control adenoviral vector encoding the gastrin-releasing peptide receptor did not have tumor localization of [(111)In]-DTPA-D-Phe1-octreotide (<1.6% ID/g), demonstrating specificity of [(111)In]-DTPA-D-Phe1-octreotide for the AdCMVhSSTr2 induced tumor cells. In another set of experiments, the tumor localization of [(111)In]-DTPA-D-Phe1-octreotide was not different 1, 2, or 4 days after AdCMVhSSTr2 injection (31.8, 37.7, and 40.7% ID/g, respectively; P = 0.88), indicating that multiple injections of radiolabeled peptide can be administered with equivalent uptake over a 4-day period. [(111)In]-DTPA-D-Phe1-octreotide tumor localization in animals administered AdCMVhSSTr2 on consecutive days or 2 days apart was 22.4% ID/g and 53.2% ID/g, respectively (P = 0.009) when [(111)In]-DTPA-D-Phe1-octreotide was given 1 day after the second AdCMVhSSTr2 injection. There was no difference in [(111)In]-DTPA-D-Phe1-octreotide localization after a single AdCMVhSSTr2 injection (40.7% ID/g) or two injections of AdCMVhSSTr2 given 1 (45.9% ID/g) or 2 (53.2% ID/g) days apart, where [(111)In]-DTPA-D-Phe1-octreotide was given in each case 4 days after the first AdCMVhSSTr2 injection (P = 0.65). Therefore, two AdCMVhSSTr2 injections did not increase [(111)In]-DTPA-D-Phe1-octreotide tumor localization compared with one injection, which eliminates concerns about an immune response to a second dose of AdCMVhSSTr2. This will be the basis for a therapeutic protocol with multiple administrations of an octreotide analogue labeled with a therapeutic radioisotope.  (+info)

The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy. (5/2596)

Tamoxifen (tam), an anti-breast cancer agent, is metabolized into tam-N-oxide by the hepatic flavin-containing monooxygenase and into N-desmethyl- and 4-hydroxy-tam by cytochrome P-450s (CYPs). Additionally, tam is metabolically activated by hepatic CYP3A, forming a reactive intermediate that binds covalently to proteins. Tam and 4-hydroxyandrostenedione (4-OH-A) are currently used to treat breast cancer, and it has been contemplated that 4-OH-A be given concurrently with tam to contravene potential tumor resistance to tam. Because alterations in tam metabolism may influence its therapeutic efficacy, the effect of 4-OH-A on tam metabolism was examined. Incubation of tam with liver microsomes from phenobarbital-treated rats, in the presence of 4-OH-A (10-100 microM), resulted in marked inhibition of tam-N-demethylation and tam covalent binding and in decreased tam-N-oxide accumulation; however, there was no inhibition of the formation of 4-hydroxy-tam and of 3,4-dihydroxytamoxifen. These findings indicate that 4-OH-A inhibits CYP3A, but not P-450(s) that catalyze tam 4-hydroxylation. The diminished tam-N-oxide accumulation could be due to decreased N-oxide formation and/or due to increased N-oxide reduction. Incubation of tam-N-oxide with liver microsomes containing heat-inactivated flavin-containing monooxygenase demonstrated that 4-OH-A increases the accumulation of tam, possibly by diminishing its P-450-mediated metabolism. Kinetic studies indicate that 4-OH-A is a competitive inhibitor of CYP3A, but not a time-dependent inactivator. Consequently, the concurrent treatment of tam and 4-OH-A may result in increased tam half-life and thus could potentiate the therapeutic efficacy of tam and diminish the potential side effects of tam by inhibiting its covalent binding to proteins and possibly to DNA.  (+info)

Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium. (6/2596)

Tamoxifen is associated with an increased incidence of endometrial cancer in women. It is also a potent carcinogen in rat liver and forms covalent DNA adducts in this tissue. A previous study exploring DNA adducts in human endometria, utilizing thin layer chromatography 32P-postlabelling, found no evidence for adducts in tamoxifen-treated women [Carmichael,P.L., Ugwumadu,A.H.N., Neven,P., Hewer,A.J., Poon,G.K. and Phillips,D.H. (1996) Cancer Res., 56, 1475-1479]. However, subsequent work utilizing HPLC 32P-post-labelling [Hemminki,K., Ranjaniemi,H., Lindahl,B. and Moberger,B. (1996) Cancer Res., 56, 4374-4377] suggested that very low levels could be detected. We have sought to investigate this question further by reproducing the HPLC methodology at two centres, and analysing endometrial DNA from 20 patients treated with 20 mg/day tamoxifen for between 22 and 65 months. Liver DNA isolated from tamoxifen-treated rats was used as a positive control. We found no convincing evidence for tamoxifen-derived DNA adducts in human endometrium. HPLC elution profiles of post-labelled DNA from tamoxifen-treated women were indistinguishable from those obtained with DNA from 14 untreated women and from six women taking toremifene, an analogue of tamoxifen.  (+info)

Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. (7/2596)

Hypothalamic disease often affects the patients' personality and this also applies to pituitary tumors with suprasellar extension. We report on a patient with a 12-year history of recurrent acromegaly, treated with three transphenoidal operations, single field radiation therapy and bromocriptine/octreotide administration. During the course of follow-up she presented with self-inflicted anemia and Kleine-Levin syndrome (hypersomnia, hyperphagia and hypersexuality). Furthermore, she developed post-radiation necrosis within the right temporal lobe. Whether her neurological and personality disorders result - at least partially - from the acromegaly or the temporal lobe necrosis remains unclear.  (+info)

Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer. (8/2596)

Prostate-specific antigen (PSA) is a serine protease which may play a role in a variety of cancer types, including breast cancer. In the present study, we evaluated whether the level of PSA in breast tumour cytosol could be associated with prognosis in primary breast cancer, or with response to tamoxifen therapy in recurrent disease. PSA levels were determined by enzyme-linked immunosorbent assay (ELISA) in breast tumour cytosols, and were correlated with prognosis in 1516 patients with primary breast cancer and with response to first-line tamoxifen therapy in 434 patients with recurrent disease. Relating the levels of PSA with classical prognostic factors, low levels were more often found in larger tumours, tumours of older and post-menopausal patients, and in steroid hormone receptor-negative tumours. There was no significant association between the levels of PSA with grade of differentiation or the number of involved lymph nodes. In patients with primary breast cancer, PSA was not significantly related to the rate of relapse, and a positive association of PSA with an improved survival could be attributed to its relationship to age. In patients with recurrent breast cancer, a high level of PSA was significantly related to a poor response to tamoxifen therapy, and a short progression-free and overall survival after start of treatment for recurrent disease. In Cox multivariate analyses for response to therapy and for (progression-free) survival, corrected for age/menopausal status, disease-free interval, site of relapse and steroid hormone receptor status, PSA was an independent variable of poor prognosis. It is concluded that the level of PSA in cytosols of primary breast tumours might be a marker to select breast cancer patients who may benefit from systemic tamoxifen therapy.  (+info)

The most Testosterone popular hormonal agent substitute treatment is HGH. HGH is actually produced coming from a naturally taking place amino acid. HGH has been shown to promote development of new cells, boost bone tissue stamina, reduce swelling and also boost the manufacturing of the bodily hormones oestrogen as well as testosterone level.. It is necessary to keep in mind that there is actually a distinction between individual development hormonal agent (HGH) as well as human growth hormonal agent releaser (individual development hormonal agent releaser). The human development hormone is actually developed in a laboratory as well as at that point launched in to the physical body where it stimulates the physical body to generate added HGH.. The click here to find out more individual development hormonal agent is additionally named the padding bodily hormone. It aids to cancel the bodily hormone levels in your body. GRH induces the release and aids to stabilize the hormonal agent ...
In a meta-analysis reported in JAMA Oncology, Spring et al found that neoadjuvant endocrine therapy was associated with outcomes similar to those with chemotherapy in women with estrogen receptor-positive breast cancer.. Similar Outcomes. The analysis included 3,490 patients from 20 randomized trials of neoadjuvant therapy containing ≥ 1 endocrine therapy arm. Compared with combination chemotherapy, endocrine therapy alone was associated with a similar clinical response rate (odds ratio [OR] = 1.08, P = .85), radiologic response rate (OR = 1.38, P = .12), and breast-conserving surgery rate (OR = 0.65, P = .07), with endocrine therapy alone being associated with reduced toxicity. Compared with tamoxifen, aromatase inhibitor use was associated with a better clinical response rate (OR = 1.69, P , .001), radiologic response rate (OR = 1.49, P , .001), and breast-conserving surgery rate (OR = 1.62, P , .001). Compared with endocrine therapy alone, dual combination therapy with growth factor pathway ...
In a recent committee opinion, the American College of Obstetricians and Gynecologists (ACOG) approved the use of low-dose vaginal estrogen products to relieve vaginal dryness, painful sex and related symptoms in women treated for hormone receptor-positive breast cancer.Such products - estrogen-based creams, vaginal rings and vaginal tablets - may be used when non-hormonal treatments have proven unsuccessful, ACOG noted. Women should receive information on the possible benefits and risks of vaginal estrogen use and coordinate the decision with their oncologist, the group stated.
Bodily Hormone PRP Treatment or even HRT is actually an extensive condition which involves the many different sorts of procedures for hormonal agent imbalances that can easily develop during adolescence as well as pregnancy. Procedure making use of hormone blockers, hormonal agent releasers or hormone mimickers can also be actually called HRT or even postmenopausal bodily hormone therapy.. The primary function of HRT is actually to stop any sort of increase and reduce in the amount of the sex hormonal agent, estradiol (additionally understood as estrogen). It may likewise trigger mood swings, body weight gain, genital dry skin as well as menopausal signs and symptoms such as hot flashes as well as evening perspirations.. To useful link address hormone-related concerns, HRT works by either restraining the creation of estrogens or blocking their absorption right into the blood stream by means of the ovary. There are numerous different medicines that are actually on call to regulate or even lessen ...
Hormone PRP therapy, at times called hormonal agent substitute therapy, is the therapy with hormones for medical reasons. The best typical hormonal agent therapy utilized is estrogen substitute treatment.. Bodily hormones and also bodily hormone replacement therapy have actually been actually a method of addressing the indicators of menopause, but are right now being actually utilized in various other kinds of procedure for various kinds of medical conditions. Hormonal agent replacement therapy can be called, holistic medicine, endocrinology, as well as gynecologic medicine.. The most typical treatment utilizing women bodily hormones is actually estrogen substitute therapy. This treatment operates through boosting the creation of estrogen in the body system. The problem using this type of treatment is that there is actually certainly not a sufficient amount of estrogen in the body to accomplish its own job appropriately. There is actually a deficiency of oestrogen which is inducing many of the ...
ER-positive breast cancer is commonly treated with adjuvant endocrine therapies. Adjuvant endocrine treatment has been shown to increase overall survival and in light of recent studies is likely to be recommended for even longer duration in the adjuvant setting (40, 41). However, many patients do not benefit from these therapies and predictors for response or resistance to endocrine treatment are urgently needed. In this study, we report a meta-analysis of two genome-wide studies and two validation datasets for identifying genetic variants associated with breast cancer-related mortality specifically after adjuvant endocrine treatment. In a meta-analysis involving individuals treated with adjuvant endocrine therapy, we identified SNP rs8113308 specifically and significantly predicting outcome after endocrine treatment. We were further able to show that among patients with ER-positive tumors, there is a significant interaction between the rs8113308 and endocrine treatment, indicating a predictive, ...
Researchers examine the effect of different adjuvant endocrine therapies on disease recurrence in premenopausal women with ER+ breast cancer.
The most Testosterone common hormonal agent substitute therapy is HGH. HGH is produced from a typically happening amino acid. HGH has actually been revealed to stimulate development of new tissues, boost bone toughness, lower swelling and boost the manufacturing of the hormonal agents oestrogen as well as testosterone.. It is important to note that there is a difference in between individual growth hormonal agent (HGH) and human growth hormone releaser (individual growth bodily hormone releaser). SGRH). Human Development Bodily Hormone is actually the more popular of the two. The human growth bodily hormone is made in a lab and afterwards introduced into the body system where it stimulates the physical body to create added HGH.. The top article human growth hormone is actually also named the padding hormonal agent. It assists to cancel the hormonal agent amounts in your body. GRH promotes the release as well as helps to balance the hormonal agent degrees.. So while the threats of using ...
PRIMARY OBJECTIVES:I. To compare whether the addition of one year of everolimus (10 mg daily) to standard adjuvant endocrine therapy improves invasive
Hormone Hormone Therapy Treatment or even hormonal agent substitute treatment is the practice of utilization particular hormonal agents in a health care treatment for health conditions that belong to bodily hormones. Hormonal agents are compounds produced due to the physical body that manage numerous physical functions. Hormonal agent therapies may either be actually prescribed by a medical professional or even might be acquired nonprescription at a health food retail store.. Hormone replacement treatment, frequently called HRT, is the clinical therapy of using certain hormonal agents in the physical body in purchase to change a bodily hormone or to provide comfort from the results of a condition. Other Bodily hormones that can easily be actually made use of to help stability bodily hormones are actually thyroid hormones as well as the sexual activity hormones.. It has actually been actually located that hormone therapy, when done appropriately as well as securely, could be a quite efficient ...
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The Relationship In Between SARMs and Peptides. There has been a boosting demand for choices to artificial hormonal agents among athletes who want to enhance their muscular tissue mass in a much shorter time period. As contrasted to other hormones, artificial hormonal agents do not have any type of adverse effects besides the start of menopause. Nevertheless, utilizing artificial hormonal agents for muscle mass improvement can have its very own downsides. One of the problems with these kinds of hormone supplements is that they cause high blood pressure and increase the threat of cardiovascular disease. The major distinction between SARMs capsules is that SARMs are in fact a type of androgenic hormone that helps in muscular tissue development by binding to androgen receptors in the body while sarsas are a type of nutritional supplement that boosts the release of testosterone in the body normally. It is believed that these 2 types of hormonal agents can work together and also this is the main ...
Learn about the veterinary topic of Hormonal Agents. Find specific details on this topic and related topics from the Merck Vet Manual.
Prosigna is indicated for use in postmenopausal women with hormone receptor-positive, node-negative (Stage I or II) or node-positive (Stage II or IIIA) early-stage breast cancer to be treated with adjuvant endocrine therapy.. ...
Prosigna is indicated for use in postmenopausal women with hormone receptor-positive, node-negative (Stage I or II) or node-positive (Stage II or IIIA) early-stage breast cancer to be treated with adjuvant endocrine therapy.. ...
In this investigation, we delineate a pathway involving the MutL complex, along with ATM, CHK2, and CDK4/6 that is required for ER+HER2− tumors to respond to endocrine therapy (Fig. 6G). When components of this pathway are poorly expressed or lost through mutation, feedback control on CDK4/6 is defective. This allows the cell cycle to proceed despite DNA mismatches, thereby promoting the growth of high mutation load ER+ breast cancers that are intrinsically resistant to endocrine treatment, but still sensitive to CDK4/6i.. The sequential triple biopsy design of the NeoPalAna trial was executed to determine the effects of CDK4/6i on ER+ HER2− tumors where intrinsic endocrine therapy resistance had been demonstrated. Consistent with our model, CDK4/6i was uniformly effective in suppressing residual proliferation in MutL−ER+ breast cancers, with almost undetectable Ki67 levels after approximately 2 weeks of palbociclib exposure. In contrast, the degree to which each mutant MutL allele or ...
If you are about to undergo hormonal therapy, there are many questions you may want to ask your doctor. Learn these common hormonal therapy questions today.
Calabasas Ca, 16 th Might 2021, ZEXPRWIRE-- Human beings are wired to start reactions when the body views a risk. If the Amygdala in the brain illuminate, it indicates the Hypothalamus and a neuroendocrine procedure starts that triggers the body to launch tension hormonal agents such as cortisol. Persistent tension and worry can stop the…
TY - JOUR. T1 - A phase II feasibility study of palbociclib in combination with adjuvant endocrine therapy for hormone receptor-positive invasive breast carcinoma. AU - Mayer, E. L.. AU - Demichele, A.. AU - Rugo, H. S.. AU - Miller, K.. AU - Waks, A. G.. AU - Come, S. E.. AU - Mulvey, T.. AU - Jeselsohn, R.. AU - Overmoyer, B.. AU - Guo, H.. AU - Barry, W. T.. AU - Huang Bartlett, C.. AU - Koehler, M.. AU - Winer, E. P.. AU - Burstein, H. J.. PY - 2019/9/1. Y1 - 2019/9/1. N2 - Background: The CDK4/6 inhibitor palbociclib prolongs progression-free survival in hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer when combined with endocrine therapy. This phase II trial was designed to determine the feasibility of adjuvant palbociclib and endocrine therapy for early breast cancer. Patients and methods: Eligible patients with HR+/HER2- stage II-III breast cancer received 2 years of palbociclib at 125 mg daily, 3 weeks on/1 week off, with endocrine therapy. The primary end ...
To provide statements and recommendations, based on the best available evidence, about the use of aromatase inhibitors as adjuvant endocrine therapy for post-menopausal women with hormone receptor-positive early invasive breast cancer.
American Cancer Society. Hormone Therapy for Breast Cancer. www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-hormone-therapy. Accessed August 31, 2015.. American Society for Clinical Oncology. Hormone Therapy for Hormone Receptor-Positive Breast Cancer. www.cancer.net/research-and-advocacy/asco-care-and-treatment-recommendations-patients/hormonal-therapy-hormone-receptor-positive-breast-cancer. Accessed August 31, 2015.. Harold J. Burstein, Sarah Temin, Holly Anderson, et al. Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update. J Clin Oncol . 2014 May 27. National Cancer Institute. Hormone Therapy for Breast Cancer. www.cancer.gov/types/breast/breast-hormone-therapy-fact-sheet. Accessed August 31, 2015.. ...
ASCO recently released a clinical practice guideline update on ovarian suppression as part of the extant guideline on adjuvant endocrine therapy in hormone receptor-positive breast cancer, and the recommendations were summarized in the June 10, 2016, issue of The ASCO Post. Also in this issue, Katarzyna J. Jerzak, MD, FRCPC, and Kathleen I. Pritchard, MD, FRCPS, of Sunnybrook Odette Cancer Centre, University of Toronto, offered their perspective on the implications of this 2016 ASCO Guideline for Clinical Practice.. The 2016 ASCO Clinical Practice Guideline, Update on Ovarian Suppression (updated from Guideline on Ovarian Ablation in the Treatment of Premenopausal Women With Early-Stage Invasive Breast Cancer), uses only the term ovarian suppression (with LHRH [luteinizing hormone-releasing hormone] agonists) in the recommendations and in all the discussion.1-3 The focus of the updated guideline is clearly on the question of combined ovarian function-targeting plus endocrine therapies. ...
Clinical equipoise exists around the optimal time to start adjuvant endocrine therapy in patients who will receive post-operative radiotherapy for breast cancer. Patients receive either concurrent or sequential endocrine and radiation therapy, where concurrent therapy consists of endocrine therapy started before, with or during radiotherapy, while sequential treatment is defined as endocrine therapy starting after the completion of radiotherapy. A recent survey of Canadian oncologists showed that the main reason for prescribing sequential endocrine therapy was a concern that concurrent endocrine therapy and radiotherapy would worsen the toxicity of endocrine treatment. This is despite the absence of any clinical trial evidence to support this. Indeed, a recent systematic review by our group was unable to confirm or refute whether increased toxicities, related to the timing of endocrine therapy and radiotherapy actually exist in clinical practice. The investigators are therefore proposing a ...
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Bodily hormone BHRT treatment, sometimes referred to as bodily hormone substitute therapy, is actually the procedure with hormones for health care objectives. The most popular hormone treatment made use of is estrogen replacement therapy.. Hormonal agents and also hormonal agent substitute therapy have been a method of dealing with the signs and symptoms of menopause, but are now being used in other types of treatment for various types of health care conditions. Bodily hormone replacement therapy can be referred to as, natural medicine, endocrinology, as well as gynecologic medication.. The most common therapy making use of women bodily hormones is oestrogen substitute treatment. This treatment works by increasing the creation of oestrogen in the body system. The problem through this form of procedure is that there is certainly not an adequate volume of estrogen in the physical body to carry out its job adequately. As a matter of fact, there is actually a scarcity of oestrogen which is actually ...
Purpose: To examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up. Patients and Methods: This report analyzes 4,760 patients with breast cancer randomly assigned to 5 years of monotherapy with letrozole or tamoxifen in the BIG 1-98 trial with available information on BMI at randomization. Multivariable Cox modeling assessed the association of BMI with disease-free survival, overall survival (OS), breast cancer-free interval, and distant recurrence-free interval and tested for treatment-by-BMI interaction. Median follow-up was 8.7 years. Results: Seventeen percent of patients have died. Obese patients (BMI >= 30 kg/m²) had slightly poorer OS (hazard ratio [HR] = 1.19; 95% CI, 0.99 to 1.44) than patients with normal BMI (< 25 kg/m²), whereas no trend in OS was observed in ...
BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen. METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,457) in early breast cancer of about 5 years of tamoxifen versus no adjuvant tamoxifen, with about 80% compliance. Recurrence and death rate ratios (RRs) were from log-rank analyses by allocated treatment. FINDINGS: In oestrogen receptor (ER)-positive disease (n=10,645), allocation to about 5 years of tamoxifen substantially reduced recurrence rates throughout the first 10 years (RR 0.53 [SE 0.03] during years 0-4 and RR 0.68 [0.06] during years 5-9 [both 2p|0.00001]; but RR 0.97 [0.10] during years 10-14, suggesting no further gain or loss after year 10). Even in marginally ER-positive disease (10-19 fmol/mg
One in six women with early, operable breast cancer may not need years of adjuvant hormonal therapy after primary treatment. This was the conclusion of a recent study published in JAMA (the Journal of the American Medical Association) Oncology.
Although mechanisms of acquired resistance to endocrine therapy have been identified in estrogen receptor-positive (ER+) breast cancer, the causes of intrinsic resistance, present at the time of diagnosis, are less well understood. Haricharan and colleagues linked loss of the MutL mismatch repair (MMR) complex to intrinsic resistance to endocrine therapy. MMR has two damage-sensing complexes: MutS and MutL. In patients with ER+ breast cancer, endocrine therapy resistance was associated with dysregulation of MutL but not MutS. In ER+ breast cancer cell lines, silencing of MutL complex genes promoted resistance to endocrine therapy (including estrogen deprivation, a surrogate for aromatase inhibitor exposure, fulvestrant, and tamoxifen) by preventing CHK2-mediated inhibition of CDK4/6, resulting in deregulated CDK4/6 activity that drove endocrine therapy resistance. Further, mutations that dysregulated MutL promoted resistance to endocrine therapy in patient-derived xenograft models. Response to ...
The majority of breast cancer patients discontinues todays standard adjuvant treatment (endocrine therapy) due to side effects and reduced quality of life. Thereby, most side effects are unspecific, suggesting a role of psychological factors as patients´ expectations (nocebo effects). Moreover, patients are not informed sufficiently about their treatment.. Using a longitudinal design, the nature and onset of adverse side effects and their association to treatment related expectations are investigated. Postoperative patients with hormone receptor-positive breast cancer are assessed before the start of adjuvant treatment. All patients receive standardized, additional information about endocrine therapy. Expectations about side effects, knowledge and satisfaction with the enhanced information are assessed before and after informing patients. Side effects, quality of life and adherence are measured three months, two and five years after start of medication intake.. It will be analyzed if patients ...
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The review by Drs. Ruta Rao and Melody Cobleigh in this issue of ONCOLOGY summarizes the state-of-the-art adjuvant hormonal therapy for breast cancer concisely and appropriately.
BACKGROUND:The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib, in combination with fulvestrant therapy, prolongs progression-free survival among patients with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. We report the results of a prespecified analysis of overall survival. METHODS:We randomly assigned patients with hormone-receptor-positive, HER2-negative advanced breast cancer who had progression or relapse during previous endocrine therapy to receive palbociclib plus fulvestrant or placebo plus fulvestrant. We analyzed overall survival; the effect of palbociclib according to the prespecified stratification factors of presence or absence of sensitivity to endocrine therapy, presence or absence of visceral metastatic disease, and menopausal status; the efficacy of subsequent therapies after disease progression; and safety. RESULTS:Among 521 patients who underwent randomization, the median overall survival was 34.9 ...
Anavar is a dihydrotestosterone (DHT) acquired anabolic androgenic steroid. Specifically, this is an altered kind of the DHT hormonal agent; it is the DHT hormonal agent with an added oxygen atom replacing the carbon-2 in the A-ring. This structural adjustment protects against the hormonal agent from being metabolically broken down, along with enhances its anabolic task substantially. There is also a 2nd change of worthwhile note in that there is a structural change to the hormonal agent at the 17th carbon placement through the enhancement of an included methyl group. This change enables the hormone to make it through dental ingestion and officially categorizes Anavar as a C17-alpha alkylated (C17-aa) anabolic steroid. This additionally creates the steroid to lug a hepatotoxic nature, although reasonably light.. Although frequently described as a light steroid, Anavar is very anabolic; as a matter of fact, its anabolic ranking is 3-6 times more powerful compared to testosterone resting at ...
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The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
(Medical Xpress)-A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive ...
Researchers at Karolinska Institutet in Sweden have investigated the long-term effect of hormonal therapy in women with the most common types of hormone-sensitive breast cancer. The results, presented in the journal JAMA Oncology, show that the treatment has a protective effect against distant metastatic cancer…. ...
Conclusion The benefit of Pin HER2+ early BC is maintained, with the greatest benefit continuing to be observed in the node positive population. With longer follow-up, the benefit of P no longer appears to depend on HR status. Continued follow up of patients is very important to determine possible benefit for OS. A calendar-driven third interim OS analysis is planned in 2.5 years, and the event-driven final OS analysis is planned when 640 deaths have occurred.. Addition of S-1 to Post-operative Endocrine Therapy Improves Outcomes for Patients with Hormone Receptor-positive, HER2-negative Breast Cancer:. ABSTRACT Publication Number: GS1-09 Addition of S-1 to endocrine therapy in the post-operative adjuvant treatment of hormone receptor-positive and human epidermal growth factor receptor 2-negative primary breast cancer: A multicenter, open-label, phase 3 randomized trial(POTENT trial). Masakazu Toi, Shigeru Imoto, Takanori Ishida, Yoshinori Ito, et al.. ...
Hormonal agent Testosterone therapy is actually merely the utilization of hormones in a clinical procedure. Many types of bodily hormone treatment may additionally be actually called hormonal supplements or anti-hormones treatment. It features the administration of hormones, treatments and also inhalation of drugs that improve the levels of testosterone level, estrogen and progesterone in the physical body.. When the physical body produces also couple of bodily hormones, ovulation comes to be off-balance, creating infertility. When ladies develop brittle bones, this is actually generally linked with a discrepancy in her hormonal agents.. An individual wikipedia reference may look for the support of a medical professional that is actually certified to prescribe medications for HRT. One of the most common drugs for HRT include contraceptive pills, artificial hormonal agent substitutes, gingivitis and also amenorrhea.. The very most well-known is the usage of childbirth control tablets, commonly ...
In this issue of Clinical Cancer Research, Fox and colleagues report a prospective tamoxifen dose-escalation study in patients with low endoxifen concentrations during treatment (1). Tamoxifen is highly effective for preventing recurrence of hormone receptor (HR+) breast cancer; however, approximately 15% of patients will recur within 5 years despite adjuvant treatment (2). Tamoxifen is believed to be a prodrug with part of the antiestrogen activity attributed to endoxifen, which is produced primarily via CYP2D6-catalyzed metabolism. There is substantial variability in endoxifen concentration in patients on tamoxifen treatment, and there is some evidence that patients with low endoxifen concentrations during tamoxifen treatment are at increased risk of cancer recurrence (3, 4). On the basis of this putative association between endoxifen concentration and tamoxifen treatment efficacy, several studies have prospectively dose-escalated patients who have low-activity CYP2D6 genotype and predicted, ...
Cortisol is a steroid hormonal agent launched by a bodys adrenal glands. It is typically described as atension hormonal agent. Although cortisol is necessary for working in daily life, its harmful when cortisol degrees continue to be high for as well lengthy.. To damage down the procedure, cortisol secretion is done by an adrenocorticotropic hormonal agent, which belongs to the HPA axis. This entails the hypothalamus, the pituitary gland, and also the adrenal gland. With each other, they regulate the bodys response to stress and anxiety- as well as likewise control food digestion, the body immune system, state of mind, feelings, sexuality, and also power storage space.. High cortisol degrees can trigger hypertension, high blood glucose degrees, weight gain, rest deprival, insulin resistance, reduced power, cardiovascular disease, and also bad memory. High cortisol might likewise bring about Cushings illness, which takes place when a body makes way too much cortisol by itself for an extensive ...
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
A low dose of tamoxifen after surgery reduced the risk of recurrence, as well as the risk of new invasive disease, in women diagnosed with hormone-receptor-positive breast intraepithelial neoplasia.
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Feb 04, 2020 (The Expresswire)- DO you think your sweet tooth is the reason behind your increasing kilos? Is exercise, diet plan absolutely nothing helping you to regain your real waist size? If you are reading the article, the answer most likely is yes. So whats the reason? Why in spite of all the efforts and the hard minutes of avoiding your favourite snacks you are still unable to reduce your weight? There might be different reasons for increase in weight.. For e.g. for individuals who have put on weight due to the fact that of excess of sweet consuming, the factor is not the sugar-craving, rather sugar-craving is simply the sign and the real factor stays unaddressed. One of the major reasons of weight gain in many of the cases is leptin resistance. Leptin is a hormone in our body which is likewise understood as obesity hormone, fat hormonal agent and also as hunger hormonal agent sometimes.. ...
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I am so glad I found this blog! Ive been on tamoxifen for 14 months. They really should have a warning label that says will alter your life on the bottle!!!! I had stage 1b BC ER/PR positive at age 38, did not reach my lymph nodes, thank god, no chemo or radiation. I quickly became depressed after I started taking the tamoxifen, I thought I was going through depression due to all the fear & scare I had gone through. Plus my reconstruction had been very painful & couldnt find any answers as to why it was so painful, so I was depressed. My period was normal until I took the tamoxifen, it changed to every 5 to 6 weeks instead of 4 & was very light. Over time it went back to my regular flow & time. I decided to start a period tracker app on my phone, thought it would be a good idea. About 6 months after taking tamoxifen I noticed that my mood was like a light switch & the depression was so bad, plus cramps body aches,loss of sex drive, fog you name it. The brain fog is the worst for me I cant ...
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Steroid hormones mediate critical lineage-specific developmental and physiologic responses. They function by binding their cognate receptors, which are transcription factors that drive specific gene expression programs. The requirement of most prostate cancers for androgen and most breast cancers for estrogen has led to the development of endocrine therapies that block the action of these hormones in these tumors. While initial endocrine interventions are successful, resistance to therapy often arises. We will review how steroid receptor-dependent genomic signaling is affected by genetic alterations in endocrine therapy resistance. The detailed understanding of these interactions will not only provide improved treatment options to overcome resistance, but, in the future, will also be the basis for implementing precision cancer medicine approaches.. ...
This is a two stage study, with an initial dose escalation phase I study and subsequent double blind randomised phase II controlled trial. Eligible patients are post-menopausal women with metastatic ER+ breast cancer not suitable for surgical resection. Patients should be suitable for endocrine treatment, but have received no more than 3 previous lines of endocrine treatment and up to 1 line of chemotherapy for metastatic disease. They will also have had progressive disease during treatment with an aromatase inhibitor. Following the dose-escalation in stage 1, patients will be randomised to receive fulvestrant plus either placebo or 480mg (or maximum tolerated dose) of AZD5363 oral capsules or tablets taken once daily. Patients will receive fulvestrant in combination with either placebo or AZD5363 until disease progression. Patients may continue to receive fulvestrant and AZD5363/placebo treatment even after the last trial visit. ...
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Download the article Dynamics of pathological factors after «test» course of preoperative endocrine therapy in menopausal patients with earlyer positive breast cancer and its effect on survival
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Evidence-based recommendations on hormonal therapies (anastrozole/exemestane/letrozole) as extra treatment for early oestrogen-receptor-positive breast cancer
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"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Nathanson ... "Hormonal Therapy". breastcancer.org. 26 July 2007. Retrieved 4 March 2008. Kurzer MS (2002). "Hormonal effects of soy in ... Estrogens are involved in breast development and may be used as a form of hormonal breast enhancement to increase the size of ... An estrogen (E) is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy, ...
ISBN 978-3-642-99941-3. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. ... 185-. ISBN 978-3-642-65806-8. Goldenberg IS, Hayes MA (1959). "Hormonal therapy of metastatic female breast carcinoma. I. 9 ... Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Halogenated ... Tyler, Edward T. (1959). "Fertility promoting and inhibiting effects of new steroid hormonal substances". Journal of the ...
List of hormonal cytostatic antineoplastic agents Oborotov, A. V.; Smirnova, Z. S.; Osetrova, I. P.; Polozkova, A. P.; ... Cytestrol acetate is a steroidal antiestrogen and a cytostatic antineoplastic agent (i.e., chemotherapeutic) which was ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters NCI Thesaurus. "Alestramustine". ... Milne GW (1 July 2000). Ashgate Handbook of Antineoplastic Agents. Wiley. p. 5. ISBN 978-0-566-08382-2. Tripathi KD (30 ... is a cytostatic antineoplastic agent which was never marketed. It is the L-alanine ester of estramustine, which is a ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters J. Elks (14 November 2014). The Dictionary of Drugs: ... nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of ...
List of hormonal cytostatic antineoplastic agents List of corticosteroid esters J. Elks (14 November 2014). The Dictionary of ... 868-. ISBN 978-3-88763-075-1. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters J. Elks (14 November 2014). The Dictionary of Drugs: ... nonsteroidal estrogen and cytostatic antineoplastic agent (i.e., chemotherapy drug) and a chlorphenacyl nitrogen mustard ester ... Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM (1988). "[The antineoplastic activity of testiphenon]". Vopr ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters Elks J (14 November 2014). The ... Estramustine (INN, USAN, BAN) is an estrogen and cytostatic antineoplastic agent which was never marketed. It is an estrogen ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters J. Elks (14 November 2014). The ... steroidal estrogen and cytostatic antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was ... 898-. ISBN 978-1-4757-2085-3. Asai M, Takeuchi H, Okada H (1978). "In vivo interaction between steroidal alkylating agents and ... V. H. T. James; J. R. Pasqualini (22 October 2013). Hormonal Steroids: Proceedings of the Sixth International Congress on ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters J. Elks (14 November 2014). The ... is a cytostatic antineoplastic agent which was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the ... Ohsawa N, Yamazaki Z, Wagatsuma T, Isurugi K (1984). "[Bestrabacil: a possible target-oriented anticancer agent]". Gan to ...
List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters Chabner BA, Longo DL (7 December ... is a major active metabolite of the cystotatic antineoplastic agent and estrogen estramustine phosphate, a medication used in ...
List of hormonal cytostatic antineoplastic agents List of corticosteroid esters Lagova ND, Kiselev VI, Kurdiumova KN, Sof'ina ... is a synthetic glucocorticoid corticosteroid and cytostatic antineoplastic agent which was developed in Russia for potential ... V.; Khalanskii, A. S.; Gershtein, E. S.; Gerasimova, G. K. (1999). "Dependence of antitumor effect of hormonal cytostatic ...
"In Sartorelli AC, Johns DJ (eds.). Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ... Segaloff A, Horwitt BN, Cakabasi RA, Murison PJ, Osser JV (1955). "Hormonal therapy in cancer of the breast.VIII. The effect of ... Morton I, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & ... However, androstanolone is nonetheless described as a very poor anabolic agent.[35] This is attributed to its high affinity as ...
List of hormonal cytostatic antineoplastic agents List of androgen esters § Dihydrotestosterone esters Lagova ND, Sof'ina ZP, ... and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed. It is an androgen ester - specifically ... Shkodinskaia EN, Kurdiumova KN, Valueva IM (1988). "[The antineoplastic activity of testiphenon]". Vopr Onkol (in Russian). 34 ...
Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... The primary ones include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and palliative care. ... Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and ... Traditional chemotherapeutic agents act by killing cells that divide rapidly, a critical property of most cancer cells. It was ...
... an NSAA which is used as a hormonal antineoplastic agent in the treatment of metastatic prostate cancer. It has similar ...
... which was developed as a cytostatic antineoplastic agent but was never marketed. List of hormonal cytostatic antineoplastic ... nitrosocarbamates as potential anticancer agents". J. Med. Chem. 43 (8): 1484-8. doi:10.1021/jm990417j. PMID 10780904. J. Elks ... agents List of androgen esters § Nandrolone esters Reynolds RC, Tiwari A, Harwell JE, Gordon DG, Garrett BD, Gilbert KS, Schmid ...
... used but now-discontinued progestin ethisterone and the experimental and never-marketed hormonal antineoplastic agent ...
... is a novel antiestrogen and experimental hormonal antineoplastic agent which is being researched for the potential treatment of ... Ekoue DN, Unni N, Raj GV (April 2018). "A new class of agents for estrogen-receptor-positive breast cancer". Expert Rev Clin ...
List of hormonal cytostatic antineoplastic agents Antiestrogen withdrawal response DeVita, Vincent T.; Hellman, Samuel; ... Selective estrogen receptor modulators (SERMs) are an important class of hormonal therapy agents which act as antagonists of ... although another class of hormonal agents, aromatase inhibitors, now have an expanding role in that disease. One effective ... Hormonal therapy in oncology is hormone therapy for cancer and is one of the major modalities of medical oncology ( ...
Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 181-. ISBN 978-3-642-65806-8. Heinrich Kahr ... This is a list of known sex-hormonal crystalline aqueous suspension formulations. Brand names and developmental code names are ... "Long-acting hormonal contraceptives for women". J. Steroid Biochem. Mol. Biol. 40 (4-6): 697-704. doi:10.1016/0960-0760(91) ... List of combined sex-hormonal preparations List of androgen esters List of estrogen esters List of progestogen esters Alan C. ...
This is a list of dual hormonal and cytostatic antineoplastic agents. Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC- ...
Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp ... Gruhn JG, Kazer RR (11 November 2013). Hormonal Regulation of the Menstrual Cycle: The Evolution of Concepts. Springer Science ... "Hormonal modulation of singing: hormonal modulation of the songbird brain and singing behavior". Annals of the New York ...
... as well as the nitrogen mustard alkylating antineoplastic agent estramustine phosphate (estradiol normustine phosphate). The ... Estrogen esters are used in hormone therapy, hormonal contraception, and high-dose estrogen therapy (e.g., for prostate cancer ...
MGA is also used as an antineoplastic agent in the treatment of breast cancer and endometrial cancer. It is significantly ... Gordon D, Horwitt BN, Segaloff A, Murison PJ, Schlosser JV (March 1952). "Hormonal therapy in cancer of the breast. III. Effect ... 554-. ISBN 978-3-642-96158-8. Horský J, Presl J (1981). "Hormonal Treatment of Disorders of the Menstrual Cycle". In Horsky J, ... Maltry, E. (1970). Use of megestrol acetate (a new progestational agent) in the treatment of carcinoma of the prostate. In ...
... danazol became the primary hormonal agent used in the treatment of endometriosis. In the 1990s the GnRH agonists have become ... an estradiol ester that is also a cytostatic antineoplastic agent; used for prostate cancer only) Ethinylestradiol, its ether ... Pseudopregnancy simulates the hormonal profile of the first trimester of pregnancy. HDE has been used since the discovery and ... In the early 1950s the high-dose estrogen regimen of Karnaky was the only available hormonal treatment for endometriosis. In ...
... antineoplastic agents, alkylating MeSH D27.505.954.248.169 - antineoplastic agents, hormonal MeSH D27.505.954.248.179 - ... MeSH D27.505.519.124 - alkylating agents MeSH D27.505.519.124.035 - antineoplastic agents, alkylating MeSH D27.505.519.155 - ... lipotropic agents MeSH D27.505.954.248 - antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505. ... alkylating agents MeSH D27.888.569.035.035 - antineoplastic agents, alkylating MeSH D27.888.569.042 - antimetabolites MeSH ...
EMP is a dual cytostatic and hence chemotherapeutic agent and a hormonal anticancer agent of the estrogen type. It is a prodrug ... Antineoplastic agents related to EMP, although none of them were marketed, include alestramustine, atrimustine, cytestrol ... EMP is described as relatively well tolerated among cytostatic antineoplastic and nitrogen-mustard agents, rarely or not at all ... and hence was thought to be an alkylating antineoplastic agent. However, subsequent research has found that EMP is devoid of ...
List of investigational hormonal agents § Estrogenics. References[edit]. *^ Gauthier, S; Cloutier, J; Dory, YL; Favre, A; ... This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.. *v ...
The agents nafarelin and triptorelin are agonists with single substitutions at position 6. ... Hormonal antineoplastic drugs. *Gonadotropin-releasing hormone and gonadotropins. *Progonadotropins. Navigation menu. Personal ... Cryptorchidism; Delayed puberty; Diagnostic agent (pituitary disorders); Hypogonadotropic hypogonadism; Veterinary medicine ( ... endometrial thinning agent); Uterine fibroids; Uterine hemorrhage. Implant. 1989. 400,000 ...
Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These ...
Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically insoluble in water, soluble in many ... Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or ... When choosing analgesics, the severity and response to other medication determines the choice of agent; the World Health ...
It may be used as a nasal/sinus decongestant, as a stimulant,[119] or as a wakefulness-promoting agent.[120] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... and anorectic agent.[112] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ... "Phenylisopropylamine stimulants: amphetamine-related agents". In Lemke TL, Williams DA, Roche VF, Zito W (eds.). Foye's ...
Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... possible roles for hormonal and non-hormonal attenuating agents". Human Reproduction Update. 20 (5): 759-774. PMID 24833728. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs.[ ...
List of agents[edit]. Adrenaline releasing agents[edit]. Main article: Norepinephrine releasing agent ... 3 List of agents *3.1 Adrenaline releasing agents *3.1.1 Common or widely marketed ... since these agents lose effectiveness after a few days. ... Hormonal contraception. *Fertility agents. *SERMs. *Sex ...
Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... The primary ones include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy and palliative care. ... Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and ... Physical agents. Some substances cause cancer primarily through their physical, rather than chemical, effects.[63] A prominent ...
"Dermatotherapeutic Agents". Ullmann's Encyclopedia of Industrial Chemistry (7th ed.). 2007. doi:10.1002/14356007.a08_301.pub2. ... Kyriakidis I, Tragiannidis A, Munchen S, Groll AH (February 2017). "Clinical hepatotoxicity associated with antifungal agents ... "The cost effectiveness of testing for onychomycosis versus empiric treatment of onychodystrophies with oral antifungal agents ... "Current and emerging azole antifungal agents". Clinical Microbiology Reviews. 12 (1): 40-79. PMC 88906. PMID 9880474 ...
8 Immunomodulators and antineoplastics *8.1 Immunomodulators for non-malignant disease. *8.2 Antineoplastics and supportive ... Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ... Injectable hormonal contraceptives[edit]. *Estradiol cypionate/medroxyprogesterone acetate. *Medroxyprogesterone acetate. * ... Immunomodulators and antineoplastics[edit]. Immunomodulators for non-malignant disease[edit]. *Adalimumabα[note 59] ...
Within the class of medications, there is no clear evidence that one agent works better than another.[1][2] ... In British Columbia, Canada the cost of the PPIs varies significantly from 0.20 CAD to 2.38 CAD per dose while all agents in ... The cost between different agents varies significantly.[1] ... Hormonal contraception. *Fertility agents. *SERMs. *Sex ...
The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ... Diuretics increase the urine volume and dilute doping agents and their metabolites. Another use is to rapidly lose weight to ... "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and ...
"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Reducing agent (antioxidant), e.g. if epinephrine is used, then sodium metabisulfite is used as a reducing agent ... LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... This can be a factor in choosing an agent in patients with liver failure,[56] although since cholinesterases are produced in ... Even with proper administration, it is inevitable for some diffusion of agent into the body from the site of application due to ...
antifungal, alkalinizing agents, quinolones, antibiotics, cholinergics, anticholinergics, antispasmodics, 5-alpha reductase ... Hormonal contraception. *Ormeloxifene. *Spermicide. For obstetrics and gynecology[edit]. NSAIDs, anticholinergics, haemostatic ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Alkylating agents[edit]. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, ... Small biological agents[edit]. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. It ... Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of ... Immunosuppressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Hormonal antineoplastic drugs. *Progonadotropins. *Transgender and medicine. Hidden categories: *Commons category link is on ... is often reserved for agents reducing the response to estrogen.[7] ...
Agents Chemother. 12 (5): 642-6. doi:10.1128/AAC.12.5.642. PMC 429991 . PMID 303498.. ... Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, ... Virtue, RW; Alanis, JM; Mori, M; Lafargue, RT; Vogel, JH; Metcalf, DR (1967). "An anaesthetic agent: 2-orthochlorophenyl, 2- ... a PCP-receptor-acylating agent". Synapse. 1 (5): 497-504. doi:10.1002/syn.890010514. PMID 2850626.. ...
"Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review" (PDF). Respiratory Care. 60 ...
This newer parenteral estrogen application shows encouraging results of a cheap and effective hormonal therapy with a low rate ... it very slowly releases the active agent estradiol over at least several months.[20][7] ... PEP has been studied as a means of hormonal breast enhancement in women.[66] ... Hartmann BW, Laml T, Kirchengast S, Albrecht AE, Huber JC (1998). "Hormonal breast augmentation: prognostic relevance of ...
Estramustine phosphate (an estradiol ester that is also a cytostatic antineoplastic agent; used for prostate cancer only) ... danazol became the primary hormonal agent used in the treatment of endometriosis. In the 1990s the GnRH agonists have become ... Hormonal therapy. During the past 40 years, the medical management of endometriosis has become significantly more sophisticated ... Pseudopregnancy simulates the hormonal profile of the first trimester of pregnancy.[45] ...
Hormonal contraception. *Fertility agents. *SERMs. *Sex hormones. Endocrine. system (H). *Hypothalamic-pituitary hormones ...
LDL-lowering potency varies between agents. Cerivastatin is the most potent, (withdrawn from the market in August, 2001 due to ... Thurnher M, Nussbaumer O, Gruenbacher G (July 2012). "Novel aspects of mevalonate pathway inhibitors as antitumor agents". ... The first agent they identified was mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum. ... Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005, ...
... "centrally acting agents",[10] but adds a distinct category of "directly acting agents", for dantrolene.[11] Use of this ... Several of these agents also have abuse potential, and their prescription is strictly controlled.[22][23][24] ... However, it is now known not every agent in this class has CNS activity (e.g. dantrolene), so this name is inaccurate.[5] ... "M03B Muscle Relaxants, Centrally acting agents". ATC/DDD Index. WHO Collaborating Centre for Drug Statistics Methodology.. ...
It may be used as a nasal/sinus decongestant, as a stimulant,[116] or as a wakefulness-promoting agent.[117] ... Tashkin, D. P. (1 March 2001). "Airway effects of marijuana, cocaine, and other inhaled illicit agents". Current Opinion in ... Amphetamine is a norepinephrine-dopamine releasing agent (NDRA). It enters neurons through dopamine and norepinephrine ... and anorectic agent.[109] It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary ...
I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ... Hormonal treatment is part of the complex therapy for some kind of tumors, particularly the ones associated with hormone-active ... Hormonal antineoplastic drugs. *Ketones. *Prodrugs. *Propionates. *World Anti-Doping Agency prohibited substances ...
This network is made up of protein-protein interactions from Treponema pallidum, the causative agent of syphilis and other ... Targets in synapses can be modulated with pharmacological agents. In this case, cholinergics (such as muscarine) and ...
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, ... For adjuvant treatment of hormone receptor positive breast cancer , as well as hormonal treatment of advanced breast cancer in ... Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic ... A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone- ...
This is a list of dual hormonal and cytostatic antineoplastic agents. Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC- ...
Antineoplastic Agents, Hormonal. Accession Number. DBCAT000063. Description. Antineoplastic agents that are used to treat ... A synthetic estrogen that has been used as a hormonal antineoplastic agent. ... An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. ... orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat ...
"Antineoplastic Agents, Hormonal" by people in this website by year, and whether "Antineoplastic Agents, Hormonal" was a major ... Antineoplastic Agents, Hormonal*Antineoplastic Agents, Hormonal. *Hormonal Agents, Antineoplastic. *Hormonal Antineoplastic ... "Antineoplastic Agents, Hormonal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Antineoplastic Agents, Hormonal" by people in Profiles. ...
Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells ...
"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Hormonal agents, Ethers, Dermatologic drugs, Hormonal antineoplastic drugs Categories. ‹ All Categories. ‹ All Hormonal agents ...
Hormonal agents, Ethers, Aromatic compounds, Antineoplastic and immunomodulating drugs Categories. ‹ All Categories ...
Neoplastic Agents Market Emerging Trends ,, Leading Players are Roche, Novartis, Celgene - published on openPR.com ... This study provides Anti - Neoplastic Agents sales, revenue, and market share for each player covered in this report for a ... Hormonal Therapy (Biologic Therapy). Others. By Applications:. Blood Cancer. Breast Cancer. Gastrointestinal Cancer. Prostate ... The Anti - Neoplastic Agents Market report provides a detailed analysis of the global market size, regional and country-level ...
Antineoplastic Agents, Hormonal. Antineoplastic Agents. To Top. *For Patients and Families. *For Researchers ... Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ...
Antineoplastic Agents, Hormonal. Antineoplastic Agents. Steroid Synthesis Inhibitors. Enzyme Inhibitors. Molecular Mechanisms ... Experimental: Combined hormonal therapy Abiraterone acetate: 1000mg/day (four 250g tablets, orally once a day) for 126 days ... Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Prior treatment for prostate carcinoma, including prostatectomy; high intensity focused ultrasound or cryotherapy; hormonal ...
Antineoplastic Agents, Hormonal. Antineoplastic Agents. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone ... Intensity Modulated Radiotherapy Plus Adjuvant Hormonal Therapy In Localized T1b-c, T2a, N0, M0 Prostatic Carcinoma. A Phase ...
Antineoplastic Agents, Hormonal. Antineoplastic Agents. Androgen Antagonists. Hormone Antagonists. Hormones, Hormone ... and prior hormonal therapy (neoadjuvant hormonal therapy vs finasteride vs neither). ... More than 1 year since any prior neoadjuvant or adjuvant hormonal therapy for a duration of no more than 4 months ...
Antineoplastic Agents, Alkylating. Alkylating Agents. Molecular Mechanisms of Pharmacological Action. Antineoplastic Agents. ... Prior therapy with one second line hormonal therapy is allowed (i.e. bicalutamide, nilutamide, flutamide, ketoconazole, ... Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. Antirheumatic Agents. ...
Antineoplastic Agents / therapeutic use* * Antineoplastic Agents, Hormonal / therapeutic use * Aromatase Inhibitors * Breast ...
Antineoplastic Agents / therapeutic use* * Antineoplastic Agents, Hormonal / therapeutic use * Carcinoma, Renal Cell / drug ...
... antineoplastic and immunomodulating agents; B, blood and blood forming organs; C, cardiovascular system; G, genitourinary ... system and sex hormones; M, musculoskeletal system; N, nervous system; R, respiratory system; H, systemic hormonal preparations ...
Antineoplastic Agents, Hormonal. Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ... A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone- ... particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The ...
Antineoplastic Agents, Hormonal. *Stereoisomerism. *Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization. *Genotype ... Adjuvant endocrine therapy as well as other forms of targeted therapy such as HER2 inhibitors and antiangiogenic agents reduce ... Significant association of CYP2B6 transcript levels in tumors with expression of hormonal receptors was found in the ... our findings provide an immediate cue for clinical studies to evaluate the utility of PPARα ligands as safe agents for the ...
Antineoplastic Agents, Hormonal. *Gene Expression Profiling. *FISH. *Cohort Studies. *RTPCR. *long-chain-fatty-acid-CoA ligase ... The aim of the present study was to characterize the androgen receptor (AR) response in hormonal therapy-resistant PC346 cells ... In (early) prostate cancer (PCa) androgens also regulate tumor growth, which is exploited by hormonal therapies in metastatic ... Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.. PLoS One. 2011; 6(8): ...
Antineoplastic agents hormonal. Breast neoplasm. Costs and cost analysis. Fulvestrant. Neoplasm metastasis. ... Antineoplásicos hormonal. Custos e análise de custos. Fulvestranto. Metástase neoplásica. Neoplasias da mama. ... Only patients without visceral crisis and with at least one previous hormonal therapy were considered eligible. Medical charts ... Apenas pacientes sem crise visceral e com pelo menos uma terapia anterior hormonal foram considerados elegíveis. Os prontuários ...
Antineoplastics, Hormones. Class Summary. Estramustine is a conjugate of an alkylating agent to estradiol. As a single agent, ... Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an ... Antineoplastics, Antimicrotubular. Class Summary. Antimicrotubule chemotherapy agents such as docetaxel and cabazitaxel have ... Antifungal agents such as ketoconazole produce a response similar to that of antiandrogens. These agents provide an alternative ...
A hormonal antineoplastic agent. Categories:. * Info Antineoplastic Agents. * Info Aromatase Inhibitors. * Info Enzyme ...
Antineoplastic Agents, Hormonal / therapeutic use. Female. Humans. Korea. Lung / pathology, physiopathology, radiography. Lung ... CONCLUSIONS: As in other countries, in Korea LAM occurs exclusively in women and progresses despite hormonal treatment.. ... 0/Antineoplastic Agents, Hormonal; 10540-29-1/Tamoxifen; 520-85-4/Medroxyprogesterone ...
Antineoplastic Agents, Hormonal / therapeutic use*. Anxiety / etiology, psychology. Attitude to Health*. Breast Neoplasms / ... 0/Adjuvants, Pharmaceutic; 0/Antineoplastic Agents, Hormonal From MEDLINE®/PubMed®, a database of the U.S. National Library of ...
Antineoplastic agents*Cytotoxic chemotherapy*Hormonal chemotherapy. Indications and usages, anatomical therapeutic chemical and ...
Learn about the veterinary topic of Hormonal Agents. Find specific details on this topic and related topics from the Merck Vet ... of certain lymphomas with prednisone may increase resistance of neoplastic cells to subsequent cycles of antineoplastic ... Hormonal Agents By Lisa G. Barber, DVM, Assistant Professor, Cummings School of Veterinary Medicine, Tufts University ; ... Hormonal therapy for neoplasia commonly involves use of glucocorticoids. Direct antitumor effects are related to their ...
Antineoplastic agents*Hormonal chemotherapy. Indications and usages, anatomical therapeutic chemical and diseases ...
Concomitant treatment with other anti-neoplastic agents (hormonal therapy acceptable). *Patients with symptomatic brain ... For this reason women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method ... Pregnant women are excluded from this study because pexidartinib (PLX3397) and Sirolimus are agents with the potential for ... Patients who are receiving any other investigational agents concurrently. * ...
  • Discuss the pharmacology including mechanism of action, adverse reactions, dose ranges, and pharmacokinetics of the common cancer chemotherapeutic agents, hormonal and immunotherapeutic agents, and monitor their use in patients with cancer. (arizona.edu)
  • The in vitro screening of a broad range of drugs already approved for other indications is attractive as in vivo toxicity and pharmacology are well defined, and such compounds can enter GBM clinical trials rapidly either as single agents or as combinations. (biomedcentral.com)
  • This review found that anastrozole was more effective than tamoxifen in adjuvant hormonal treatment of early breast cancer in postmenopausal women, and that aromatase inhibitors should be the initial hormone therapy for its treatment. (york.ac.uk)
  • One way to go forward is to draw lessons from ancient ethnopharmacological wisdom and to evaluate the plant biodiversity for compounds with potential antineoplastic activity. (intechopen.com)
  • R-(-)-gossypol acetic acid - The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. (wikimd.org)
  • Racemetyrosine/methoxsalen/phenytoin/sirolimus sm-88 - A combination agent containing racemetyrosine, methoxsalen, phenytoin and sirolimus, with potential antineoplastic activity. (wikimd.org)
  • Radgocitabine - An analogue of the nucleoside deoxycytidine with potential antineoplastic activity. (wikimd.org)
  • Nab-paclitaxel/rituximab-coated nanoparticle ar160 - A formulation composed of nanoparticle albumin-bound (nab) paclitaxel, which is an albumin-stabilized nanoparticle containing the natural taxane paclitaxel, non-covalently coated with rituximab, a recombinant chimeric murine/human antibody directed against the CD20 antigen found on B-lymphocytes, with potential antineoplastic activity. (wikimd.org)
  • Nadofaragene firadenovec - A replication-deficient recombinant adenovirus encoding human interferon alpha-2b with potential antineoplastic activity. (wikimd.org)
  • Nadofaragene firadenovec/syn3 - A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFN alpha-2b) and the gene transfer enhancement agent Syn 3, with potential antineoplastic activity. (wikimd.org)
  • The most recent research has been in the field of immunotherapy and how agents that act on the immune system can be used to manage prostate cancer. (uspharmacist.com)
  • The remainder of this article focuses largely on the few immunotherapy agents that have shown promising results in patients with mCRPC. (uspharmacist.com)
  • Depending on the technology it cans classification into Chemotherapy, Targeted Therapy, Immunotherapy (Biologic Therapy), Hormonal Therapy and Others.The global Anti - Neoplastic Agents market was valued at xx million US$ in 2018 and will reach xx million US$ by the end of 2025, growing at a CAGR of xx% during 2019-2025. (amarketforecast.com)
  • The role of this study is to focus on the potential role of abiraterone acetate in treatment-naive patients newly diagnosed with high-risk localised prostate cancer requiring combined hormonal therapy and radiotherapy. (clinicaltrials.gov)
  • Three Dimensional Conformal Radiotherapy / Intensity Modulated Radiotherapy Alone Vs Three Dimensional Conformal Therapy / Intensity Modulated Radiotherapy Plus Adjuvant Hormonal Therapy In Localized T1b-c, T2a, N0, M0 Prostatic Carcinoma. (clinicaltrials.gov)
  • Patients are stratified according to SWOG performance status (0-1 vs 2), severity of disease (minimal vs extensive), and prior hormonal therapy (neoadjuvant hormonal therapy vs finasteride vs neither). (clinicaltrials.gov)
  • OBJECTIVES: To estimate the resource utilization and costs related to endocrine therapy (ET) versus chemotherapy (CT) in the treatment of hormonal receptor positive (HR+), advanced breast cancer (ABC) patients, after at least one previous ET. (usp.br)
  • Only patients without visceral crisis and with at least one previous hormonal therapy were considered eligible. (usp.br)
  • Hormonal therapy for neoplasia commonly involves use of glucocorticoids. (merckvetmanual.com)
  • By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy. (nih.gov)
  • Moreover, miR-100 favors BrCSC differentiation, converting a basal like phenotype into luminal.It induces the expression of a functional estrogen receptor (ER) and renders basal-like BrCSCs responsive to hormonal therapy.Our findings indicate a new possible therapeutic strategy, which could make aggressive breast cancers responsive to standard treatments. (nih.gov)
  • It induces the expression of a functional estrogen receptor (ER) and renders basal-like BrCSCs responsive to hormonal therapy. (nih.gov)
  • Several surveys have shown that most patients prefer oral antineoplastic drugs to intravenous treatment primarily for the convenience of a home-based therapy and ease of use [ 2 , 3 ]. (hindawi.com)
  • After platinum and paclitaxel, topotecan is the agent that has undergone the most extensive testing to define a role as second-line therapy for recurrent ovarian cancer [19, 20], and has been approved by the U.S. Food and Drug Administration (FDA) for that indication. (dailystrength.org)
  • At this point, single-agent therapy remains the most appropriate option for patients with recurrent disease. (dailystrength.org)
  • Doxorubicin in known to be an active agent in ovarian cancer, and has been evaluated in front-line therapy with cisplatin and cyclophosphamide, achieving a small impact on long-term survival that was detectable in a meta-analysis of randomized trials prior to the advent of paclitaxel [24]. (dailystrength.org)
  • This study evaluated an algorithm in which endoxifen levels and CYP2D6 genotypes were used to make hormonal therapy recommendations for patients on adjuvant tamoxifen for breast cancer. (elsevier.com)
  • 12 Medical hormonal therapy traditionally involves the use of luteinizing hormone-releasing hormone (LH-RH) agonists or antiandrogens given alone or in combination. (uspharmacist.com)
  • General Function Oxidoreductase activity, and incorporation of nolvadex d 20mg atom of oxygen Specific Function Cytochromes P nolvadex d 20mg a group nolvadex d 20mg heme-thiolate monooxygenases, and I try to use very carefully and wisely, some of which may be serious and could include cancer, seldom resulting in withdrawal of therapy with the hormonal antineoplastic agent. (thedomains.com)
  • Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses. (chemicalland21.com)
  • Oral chemotherapy agents have regimens that have novel toxicity profiles and require strict adherence for optimal therapeutic effects, frequent monitoring of laboratory parameters, monitoring for drug interactions, and proper handling and disposal methods. (uspharmacist.com)
  • BXQ-350 is a novel anti-neoplastic therapeutic agent configured from two components: Saposin C (SapC), an expressed (human) lysosomal protein, and the phospholipid dioleoylphosphatidyl-serine (DOPS), a cell membrane phospholipid (clinical formulation BXQ-350). (clinicalconnection.com)
  • The drugs Infliximab and Anti-Bacterial Agents have been mentioned in the context of this disorder. (malacards.org)
  • The existence of rare but exceptional results with immunomodulators in metastatic patients triggered initiation of trials testing these drugs, combined or not with antineoplastic agents in the adjuvant setting. (biomedcentral.com)
  • Despite much progress in our understanding of the essence of cancer, remarkable advances in methods for early diagnosis, the expanding array of antineoplastic drugs and treatment modalities, as well as important refinements in their use, this disease is among the leading causes of morbidity and mortality in many parts of the world. (intechopen.com)
  • Currently, there are more than sixty oral antineoplastic drugs available, 22 of which are oral kinase inhibitors that have gained worldwide approval since 2001 [ 1 ]. (hindawi.com)
  • Experts now estimate that more than one-quarter of the 400 antineoplastic agents now under development are planned as oral drugs [ 2 - 4 ]. (hindawi.com)
  • To ensure effectiveness of these agents while maintaining patient safety, pharmacists need to be familiar with the drugs employed. (uspharmacist.com)
  • Potential drugs being explored are either hormonally-based and impede the production of sperm, or they are non-hormonal and render the sperm dysfunctional. (usc.edu)
  • So far, developmental efforts have focused in two realms: hormonal and non-hormonal drugs. (usc.edu)
  • Human cytochrome P450 3A4 (P450 3A4) is one of the most abundant xenobiotic-metabolizing enzymes in the human liver ( 1 ) and intestine ( 2 , 3 ) and is capable of oxidizing a wide range of structurally diverse drugs, including antineoplastic, antihistaminic, cardiac, psychotropic, analgesic, hormonal, and immunosuppresant agents ( 4 ). (pnas.org)
  • Screens using human GBM cell lines revealed 22 drugs with potent anti-GBM activity, including serotonergic blockers, cholesterol-lowering agents (statins), antineoplastics, anti-infective, anti-inflammatories, and hormonal modulators. (biomedcentral.com)
  • Other hormones, see H - Systemic hormonal preparations, excl. (whocc.no)
  • Growth Failure in Children with Systemic Juvenile Idiopathic Arthritis and Prolonged Inflammation despite Treatment with Biologicals: Late Normalization of Height by Combined Hormonal Therapies. (bioportfolio.com)
  • The antineoplastic antibiotics are products of Streptomyces . (merckvetmanual.com)
  • The anthracycline antibiotics, particularly doxorubicin , have become important antineoplastic antibiotics. (merckvetmanual.com)
  • The heterogeneous adverse effects induced by antineoplastic agents (cytotoxic and novel anticancer agents, tyrosine kinase inhibitors, bexarotene- and iodine-based cancer therapies, and radioimmunotherapies) will be highlighted. (springer.com)
  • Hormonal therapies are not included. (jointcommission.org)
  • Antineoplastic Agents, Hormonal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • Sex hormones used only in the treatment of cancer (often selected strengths) are classified in L - Antineoplastic and immunomodulating agents. (whocc.no)
  • The hormonal solution, as its name implies, uses various hormones to stop or significantly reduce spermatogenesis and has been proven successful in many different studies worldwide. (usc.edu)
  • Anastrozole appeared to be more effective than tamoxifen in the adjuvant hormonal treatment of early breast cancer. (york.ac.uk)
  • Genotypic variation in CYP2D6 affects endoxifen levels, and some have argued that patients who do not efficiently metabolize tamoxifen might wish to consider alternative hormonal treatments. (elsevier.com)
  • To be eligible, studies needed to be randomised controlled trials (RCTs) that compared anastrozole with another agent in the adjuvant treatment of early breast cancer. (york.ac.uk)
  • The hormonal dependencies of endometrial as well as breast cancers suggest that this difference may be attributed to the hormonal diversities of the pre- and postmenopausal hormonal milieu. (aacrjournals.org)
  • This medication is an oral antineoplastic agent, prescribed for cutaneous T-cell lymphoma (CTCL, a type of skin cancer), lung cancer, breast cancer and Kaposi's sarcoma. (medindia.net)
  • Testolactone , or Teslac (brand name) is an antineoplastic agent that is a derivative of progesterone and is used to treat advanced stage breast cancer . (wikidoc.org)
  • Progestogens only used in neoplastic diseases, see L - Antineoplastic and immunomodulating agents. (whocc.no)
  • Our results define a dietary manipulation that can enhance the efficacy of biguanides as antineoplastic agents that target cancer cell energy metabolism. (aacrjournals.org)
  • Testolactone is a synthetic antineoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. (wikidoc.org)
  • Here, we show that serine withdrawal increases the antineoplastic effects of phenformin (a potent biguanide structurally related to metformin). (aacrjournals.org)
  • N,n-dibenzyl daunomycin - The N-alkylated analogue of the anthracycline antineoplastic antibiotic daunomycin. (wikimd.org)
  • Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer. (drugbank.ca)
  • An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. (drugbank.com)
  • Casodex 50 mg Tablet is a non-steroidal anti-cancer medicine used in men along with other specific agents for the treatment of prostate cancer. (practo.com)
  • A range of agents and techniques are currently employed in the management of prostate cancer. (uspharmacist.com)
  • Eventually, the disease progresses further, resulting in castration-resistant prostate cancer, which typically requires the use of IV antineoplastic agents to extend overall survival, mitigate pain associated with the disease, and improve quality of life. (uspharmacist.com)
  • This medication is an antineoplastic agent, prescribed for prostate cancer with prednisone. (medindia.net)
  • This leads to cell death of the CD20-expressing tumor cells that were targeted by this agent. (wikimd.org)
  • Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. (wikimd.org)
  • Glucocorticoids are considered cell-cycle nonspecific and are often used in chemotherapeutic protocols after induction by another agent. (merckvetmanual.com)
  • However, evidence from several sources suggests that treatment of certain lymphomas with prednisone may increase resistance of neoplastic cells to subsequent cycles of antineoplastic chemotherapy through induction of MDR-1-related P-glycoprotein expression. (merckvetmanual.com)
  • These findings led to investigation of metformin in preclinical cancer models, most of which demonstrate clear antineoplastic effects that are attributable to direct action on neoplastic cells and/or indirect effects resulting from alterations in the hormonal milieu ( 2 , 5-7 ). (aacrjournals.org)
  • The study was undertaken to determine the length of time between when a prescription for an oral antineoplastic agent is written by the provider and when the medication is received by the patient and to identify risk factors that significantly increase time to medication receipt. (hindawi.com)
  • This medication is a chemotherapy agent, prescribed for non-small cell lung cancer. (medindia.net)
  • This medication is an alkylating agent, prescribed for chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL). (medindia.net)
  • This medication is an alkylating agent, prescribed for certain types of cancer. (medindia.net)
  • This medication is a synthetic anti-cancer agent, prescribed for hairy cell leukemia. (medindia.net)
  • This medication is an anticancer agent, prescribed for lymphoma. (medindia.net)
  • This medication is a hormonal chemotherapy agent, prescribed for malignant neoplasms. (medindia.net)
  • This medication is an anti-cancer agent, prescribed for certain type of leukemia in people who are at least 60 years old. (medindia.net)
  • Essentially, the hormonal contraceptive inhibits the entire male reproductive system, more specifically primary male sexual characteristics. (usc.edu)
  • Know the relative onset, duration, and severity of nausea and vomiting with different chemotherapeutic agents. (arizona.edu)
  • Na17.A2 Peptide vaccine - A peptide cancer vaccine comprised of human leukocyte antigen HLA-A2-restricted peptide derived from a metastatic melanoma cell line of patient NA17, with potential immunomodulating and antineoplastic activity. (wikimd.org)
  • CONCLUSIONS: As in other countries, in Korea LAM occurs exclusively in women and progresses despite hormonal treatment. (biomedsearch.com)
  • It is the most widely prescribed antineoplastic hormonal treatment agent today. (aacrjournals.org)
  • For the past several decades, cancer treatment has entailed primarily intravenous delivery of antineoplastic agents. (hindawi.com)
  • The use of oral antineoplastic agents for cancer treatment removes the routine and continuous monitoring that was included with intravenous treatment. (hindawi.com)
  • Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. (aacrjournals.org)
  • These changes are the result of the interaction between an individual's genetic make-up and external agents including physical, chemical, and biological carcinogens [ 2 ]. (intechopen.com)
  • Na-17/mage-3.A2/ny-eso-1 peptide vaccine - A peptide cancer vaccine consisting of peptides derived from the melanoma antigen NA-17, the human leukocyte antigen HLA-A2-restricted human melanoma antigen 3 (MAGE-3.A2) and the cancer-testis antigen (NY-ESO-1), with potential immunostimulating and antineoplastic activities. (wikimd.org)
  • The study demonstrated externally verified response rates of 20.5% (23/122) for topotecan and 14% (15/114) for paclitaxel with similar progression-free and overall survival for the two agents [19]. (dailystrength.org)
  • Nab-paclitaxel - A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. (wikimd.org)
  • Experimental data indicate that the action of Vinblastine sulfate is different from that of other recognized antineoplastic agents. (drugs.com)
  • A synthetic estrogen that has been used as a hormonal antineoplastic agent. (drugbank.com)
  • Accordingly, our goals were to identify and characterize single and combination agents having anti-GBM activity that we can potentially introduce into clinical trials quickly. (biomedcentral.com)
  • First-time fill prescriptions for oral antineoplastic agents were identified. (hindawi.com)
  • An understanding of the median time involved, as well as factors affecting the time to delivery of prescriptions, will help healthcare providers better plan and prepare for the use of oral antineoplastic agents. (hindawi.com)
  • However, in recent years, the use of oral antineoplastic agents has steadily increased among patients with a cancer diagnosis. (hindawi.com)
  • With the increasing use of oral agents, patients now have more responsibility for monitoring and reporting side effects to their health care providers [ 3 , 7 ]. (hindawi.com)
  • While they have the added benefit of convenience, most new oral antineoplastic agents are more expensive than traditional intravenous chemotherapy. (hindawi.com)
  • Due to the increased costs associated with oral antineoplastic agents, many pharmacy benefit plans have implemented cost-containment mechanisms [ 3 , 7 ]. (hindawi.com)
  • With the average cost of a new oral antineoplastic drug in 2012 approximating $10,000, paying for medications can be a significant out-of-pocket expense and burden for patients. (hindawi.com)
  • A large single hospital experience using drug provocation testing and rapid drug desensitization in hypersensitivity to antineoplastic and biological agents. (bioportfolio.com)
  • Large-scale studies of Drug Provocation Testing (DPT) or Rapid Drug Desensitization (RDD) for hypersensitivity to antineoplastics and biologicals are scarce and limited to a few institutions OBJECTIVE. (bioportfolio.com)
  • A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. (drugbank.ca)