Antineoplastic Agents, Phytogenic
Leukemia P388
Amaryllidaceae Alkaloids
Ellipticines
Doxorubicin
Drug Screening Assays, Antitumor
Antibiotics, Antineoplastic
Bryostatins
Antineoplastic Agents, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Ancitabine
Neoplasms
Gallium
Depsipeptides
Tumor Cells, Cultured
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Paclitaxel
6-Mercaptopurine
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Aminoacridines
Epothilones
Cell Survival
Molecular Structure
Lactones
Daunorubicin
Fluorouracil
Bleomycin
Dose-Response Relationship, Drug
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Antineoplastic Combined Chemotherapy Protocols
Drug Resistance, Neoplasm
Prodrugs
Drug Evaluation, Preclinical
Drug Evaluation
Cell Division
Xenograft Model Antitumor Assays
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Macrolides
Neoplasms, Experimental
Methotrexate
Camptothecin
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Mice, Nude
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Enzyme Inhibitors
Drug Administration Schedule
Isoquinolines
Neoplasm Transplantation
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Drug Interactions
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Stereoisomerism
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Ovarian Neoplasms
Caspases
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Taxoids
Structure-Activity Relationship
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Phospholipid Ethers
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Cells, Cultured
Gloves, Protective
Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.
Aster Plant
Occupational Exposure
Treatment Outcome
Medical Secretaries
Oncology Nursing
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Protective Devices
Protective Clothing
Equipment Contamination
Amsacrine
Decontamination
Phlebitis
Environmental Monitoring
Hazardous Substances
Inhibitory Concentration 50
Carcinoma, Ehrlich Tumor
Floxuridine
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Drug Compounding
2-Propanol
Tumor Stem Cell Assay
Carmustine
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Topoisomerase II Inhibitors
Drug Resistance, Multiple
Farnesyltranstransferase
Oncology Service, Hospital
Comet Assay
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
Drugs, Investigational
Isocoumarins
Nitrogen Mustard Compounds
Nurses
Suramin
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Alkaloids
Plant Extracts
Mitomycin
Azacitidine
DNA Adducts
DNA Topoisomerases, Type II
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Pharmacists
Lethal Dose 50
Gene Expression Regulation, Neoplastic
Mutagenicity Tests
Metabolic Detoxication, Drug
HT29 Cells
Blotting, Western
Hydrazones
Alkylating Agents
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Mammary Neoplasms, Experimental
Organoplatinum Compounds
Octreotide
Glutathione Transferase
Mitomycins
Dehydroascorbic Acid
Anthracyclines
Electronic volume analysis of L1210 chemotherapy. (1/35913)
The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate. (+info)Various forms of chemically induced liver injury and their detection by diagnostic procedures. (2/35913)
A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (3/35913)
The Mdm2 protein is frequently overexpressed in human non-seminomatous germ cell tumours and transitional carcinoma of the bladder where it may contribute to tolerance of wtp53. Mdm2 forms an autoregulatory feedback loop with p53; the Mdm2 gene is responsive to transactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response. We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. Rapid apoptosis ensues. Global transcription is not inhibited: p21waf-1/cip1 and GADD45 expression increase in a dose dependent manner. Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. Downregulation of Mdm2 transcript occurs in cells expressing HPV16-E6 suggesting that inhibition of Mdm2 transcription is p53-independent. When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment conditions. This is the first observation of inhibition of Mdm2 transcription following treatment with topoisomerase (topo II) poisons, a feature that may be useful in tumour types where p53 is tolerated by overexpression of Mdm2. (+info)Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (4/35913)
Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera. (+info)Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (5/35913)
Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line U266. Moreover, U266 cells are inherently resistant to Fas-mediated apoptosis and express high levels of the antiapoptotic protein Bcl-xL. Blocking IL-6 receptor signaling from Janus kinases to the Stat3 protein inhibits Bcl-xL expression and induces apoptosis, demonstrating that Stat3 signaling is essential for the survival of myeloma tumor cells. These findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. (+info)Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. (6/35913)
Cellular and molecular mechanisms involved in the resistance to cytotoxic heavy metals remain largely to be characterized in mammalian cells. To this end, we have analyzed a metal-resistant variant of the human lung cancer GLC4 cell line that we have selected by a step-wise procedure in potassium antimony tartrate. Antimony-selected cells, termed GLC4/Sb30 cells, poorly accumulated antimony through an enhanced cellular efflux of metal, thus suggesting up-regulation of a membrane export system in these cells. Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays. Moreover, MK571, a potent inhibitor of MRP1 activity, was found to markedly down-modulate resistance of GLC4/Sb30 cells to antimony and to decrease cellular export of the metal. Taken together, our data support the conclusion that overexpression of functional MRP1 likely represents one major mechanism by which human cells can escape the cytotoxic effects of heavy metals. (+info)Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (7/35913)
Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8-7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. (+info)Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (8/35913)
Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise. (+info)
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Alkylating antineoplastic agent
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to ... The platinum agents are also sometimes described as nonclassical. Alkylating antineoplastic agents have limitations. Their ... List of hormonal cytostatic antineoplastic agents "Alkylating Agents". US National Library of Medicine. Archived from the ... Many of the agents are known as "classical alkylating agents". These include true alkyl groups, and have been known for a ...
List of antineoplastic agents
This is a list of antineoplastic agents used to treat cancer. Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). ...
Cell-cycle nonspecific antineoplastic agents
... (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or ... Alkylating antineoplastic agent and anthracyclins are two examples. "Chemotherapy: The Basics". OncoLink. Archived from the ... "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer ...
List of hormonal cytostatic antineoplastic agents
This is a list of dual hormonal and cytostatic antineoplastic agents. Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC- ... Antineoplastic drugs, Hormonal antineoplastic drugs, Nitrogen mustards). ...
Streptomyces griseoluteus
"Antineoplastic agents. 47. Structure of an antineoplastic agent from Streptomyces griseoluteus". Journal of the American ...
John Hooper (marine biologist)
"Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine ... "Antineoplastic agents. 257. Isolation and structure of spongistatin 1". Journal of Organic Chemistry. 58 (6): 1302-1304. doi: ...
Narcissus (plant)
The bulbs of N. poeticus contain the antineoplastic agent narciclasine. This usage is also found in later Arabian, North ... Pettit, GR; Cragg, GM; Singh, SB; Duke, JA; Doubek, DL (1990). "Antineoplastic agents, 162. Zephyranthes candida". Journal of ... "Antineoplastic Agents. 587. Isolation and Structure of 3-Epipancratistatin from Narcissus cv. Ice Follies". Journal of Natural ... as Potential Anticancer Agents". Journal of Medicinal Chemistry. 52 (4): 1100-1114. doi:10.1021/jm8013585. PMID 19199649. ...
Psymberin
Pettit GR, Xu JP, Chapuis JC, Pettit RK, Tackett LP, Doubek DL, Hooper JN, Schmidt JM (2004). "Antineoplastic agents. 520. ...
Amaryllis
Pettit, G. R.; Gaddamidi, V.; Goswami, A.; Cragg, G. M. (1984). "Antineoplastic agents,99. Amaryllis beladonna". Journal of ...
Aplidium californicum
Certain antineoplastic agents, bryostatins 4 and 5, have been extracted from Aplidium californicum and are being evaluated. ... Pettit GR, Leet JE, Herald CL, Kamano Y, Doubek DL (1986). "Antineoplastic agents, 116. An evaluation of the marine ascidian ...
Combretum caffrum
Pettit GR, Cragg GM, Singh SB (May-June 1987). "Antineoplastic agents, 122. Constituents of Combretum caffrum". Journal of ...
Prednisone
"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Bromoketoprogesterone
ISBN 978-3-642-99941-3. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. ... Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Halogenated ... Carpenter JT (1988). "Progestational agents in the treatment of breast cancer". Cancer Treat. Res. Cancer Treatment and ... Hormonal antineoplastic drugs, Organobromides, Pregnanes, Progestogens, Triketones). ...
Estrogen (medication)
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Nathanson ... 549-. ISBN 978-3-642-30725-6. The first sex steroid used as pharmacological agent was Progynon, first sold by Schering AG in ...
Allenolic acid
Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp ...
Estriol
31-. ISBN 978-1-4613-2157-6. Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer ...
Dimethylstilbestrol
83-. ISBN 978-1-4832-7299-3. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents ...
Anthramycin
Sartorelli, Alan C.; Johns, David G. (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & ... Anthramycin is an active anti-tumor agent and antibiotic. It works by inhibiting the synthesis of RNA and DNA of carcinoma ...
Hydroxyprogesterone caproate
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Crowley, ... Geller J, Fruchtman B, Newman H, Roberts T, Silva R (February 1967). "Effect of progestational agents on carcinoma of the ... Hall NR (June 2011). "What agent should be used to prevent recurrent preterm birth: 17-P or natural progesterone?". Obstetrics ... In the group of new parenteral progestational agents, three substances developed by Karl Junkmann1,2 are the most outstanding ...
Oxofluoxymesterone
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. ... Hormonal antineoplastic drugs, Human drug metabolites, Organofluorides, All stub articles, Steroid stubs, Genito-urinary system ...
Fluorometholone acetate
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Oxylone ... ISBN 978-3-88763-075-1. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and ... Hormonal antineoplastic drugs, Progestogens, All stub articles, Steroid stubs, Genito-urinary system drug stubs). ...
Androstanolone
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Council on ... However, androstanolone is nonetheless described as a very poor anabolic agent. This is attributed to its high affinity as a ... von Deutsch DA, Abukhalaf IK, Lapu-Bula R (15 October 2003). "Anabolic Doping Agents". In Mozayani A, Raymon L (eds.). Handbook ... 63-. ISBN 978-3-88763-075-1. Morton I, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and ...
Doisynolic acid
ISBN 978-0-323-13916-8. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. ...
Chlorotrianisene
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Li JJ (3 ... 219-. ISBN 978-3-88763-075-1. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties ... Hormonal antineoplastic drugs, Organochlorides, Phenol ethers, Prodrugs, Progonadotropins, Selective estrogen receptor ...
Androstenediol diacetate
Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. v t e v t e ... Hormonal antineoplastic drugs, Prodrugs, World Anti-Doping Agency prohibited substances, All stub articles, Steroid stubs, ...
Estriol (medication)
31-. ISBN 978-1-4613-2157-6. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents ... I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ...
1-Deoxysphingolipids
"antineoplastic agent (CHEBI:35610)". www.ebi.ac.uk. Retrieved 2019-10-26.{{cite web}}: CS1 maint: url-status (link) "1- ... It has the role of antineoplastic agent, which means it can inhibit or prevent the neoplasms' proliferation. It is also the ...
List of sex-hormonal aqueous suspensions
Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 181-. ISBN 978-3-642-65806-8. Heinrich Kahr ...
O6-Benzylguanine
It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA ... O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was ... Antineoplastic drugs, Experimental cancer drugs, Benzyl compounds). ...
Alestramustine
Milne GW (1 July 2000). Ashgate Handbook of Antineoplastic Agents. Wiley. p. 5. ISBN 978-0-566-08382-2. Tripathi KD (30 ... List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters NCI Thesaurus. "Alestramustine". ... is a cytostatic antineoplastic agent which was never marketed. It is the L-alanine ester of estramustine, which is a ... Antineoplastic drugs, Chloroethyl compounds, Estradiol esters, Estranes, Hormonal antineoplastic drugs, Nitrogen mustards, ...
Bohemic acid
Most of those components are antitumor agents and anthracycline antibiotics active against Gram-positive bacteria. Bohemic acid ... "The Toxicologic Evaluation of Marcellomycin-An Antineoplastic Anthracycline Antibiotic". Drug and Chemical Toxicology. 6 (1): ... Subscription or participating institution membership required.) "Antitumor agents from the bohemic acid complex. 4. Structures ... "Antitumor Agents from Bohemic Acid Complex, VI. Schaunardimycin". Journal of Natural Products. 47 (4): 698-701. doi:10.1021/ ...
Myxobacteria
One such analog, known as Ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of ... Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity. This has led ... Myxobacteria are also known to produce gephyronic acid, an inhibitor of eukaryotic protein synthesis and a potential agent for ...
Nonsteroidal antiandrogen
Now little-used due to high incidence of elevated liver enzymes and hepatotoxicity and the availability of safer agents. ... Hormonal antineoplastic drugs, Progonadotropins, Prostate cancer, Sex hormones). ... Kaur P, Khatik GL (2016). "Advancements in Non-steroidal Antiandrogens as Potential Therapeutic Agents for the Treatment of ...
Selpercatinib
Tissue agnostic antineoplastic agents). ...
Anticarcinogen
... s are different from anticarcinoma agents (also known as anticancer or anti-neoplastic agents) in that ... Chemopreventive agents, All stub articles, Antineoplastic and immunomodulating drug stubs). ... An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or ... v t e (All articles with unsourced statements, Articles with unsourced statements from June 2017, Antineoplastic drugs, ...
Neocarzinostatin
The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is ... Antineoplastic drugs, Cancer research, Enediynes, Epoxides, Carbonate esters, Experimental cancer drugs, Naphthalenes, Nine- ...
Pembrolizumab
brands, Monoclonal antibodies for tumors, Orphan drugs, Tissue agnostic antineoplastic agents, World Health Organization ... agents targeting those mutations should be used first. Assessment of PD-L1 expression must be conducted with a validated and ... in people whose tumors express PD-L1 and who have failed treatment with other chemotherapeutic agents. In July 2016, the US FDA ... for all patients and as a single agent for patients whose tumors express PD‑L1 (Combined Positive Score [CPS] ≥1) as determined ...
Cell cycle
... of Cdc25 could also be useful for the arrest of cell cycle and therefore be useful as antineoplastic and anticancer agents. ... ISBN 978-0-12-324719-3. "Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents". Archived from the ...
Allylestrenol
Kanimoto Y, Okada K (November 1991). "[Antiandrogen therapy of benign prostatic hyperplasia--review of the agents evaluation of ... Hormonal antineoplastic drugs, Obstetric drugs, Prodrugs, Progestogens). ... Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science ... The preventive effect of indeloxazine hydrochloride to the sexual dysfunction caused by anti-androgenergic agent (allylestrenol ...
Nocodazole
... is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. ...
Pipendoxifene
Hormonal antineoplastic drugs, Indoles, Piperidines, Selective estrogen receptor modulators, All stub articles, Antineoplastic ... 14-. ISBN 978-3-642-15732-5. Prudhomme M (14 June 2013). Advances in Anticancer Agents in Medicinal Chemistry. Bentham Science ...
ATC code L04
Subgroup L04 is part of the anatomical group L Antineoplastic and immunomodulating agents. Codes for veterinary use (ATCvet ...
ICI-85966
List of hormonal cytostatic antineoplastic agents List of estrogen esters J. Elks (14 November 2014). The Dictionary of Drugs: ... nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of ... Antineoplastic drugs, Estrogen esters, Hormonal antineoplastic drugs, Carbamates, Phenols, Synthetic estrogens, Chloroethyl ... compounds, All stub articles, Antineoplastic and immunomodulating drug stubs, Genito-urinary system drug stubs). ...
Sexual and reproductive health
Other hazardous agents can affect the overall health of the woman and reduce the delivery of nutrients to the fetus. Radiation ... "Antineoplastic (Chemotherapy) Drugs - Reproductive Health , NIOSH , CDC". www.cdc.gov. 2022-02-02. Retrieved 2022-03-17. " ... "Infectious Agents - Reproductive Health , NIOSH , CDC". www.cdc.gov. 2021-11-17. Retrieved 2022-03-17. "Lead & Other Heavy ... Hazards that can reduce fertility in women include: cancer treatment drugs, including antineoplastic drugs lead ionizing ...
Mapracorat
Anti-inflammatory agents, Benzofurans, Fluoroarenes, Immunosuppressants, Quinolines, Selective glucocorticoid receptor ... modulators, Trifluoromethyl compounds, All stub articles, Musculoskeletal system drug stubs, Antineoplastic and ...
Acolbifene
Hormonal antineoplastic drugs, Phenols, Piperidines, Selective estrogen receptor modulators, All stub articles, Antineoplastic ... Acolbifene/prasterone List of investigational sex-hormonal agents § Estrogenics Gauthier S, Cloutier J, Dory YL, Favre A, ...
Mary V. Relling
In her research, she focused on antineoplastic PK and PD in children, pharmacogenetics of antileukemia therapy and host- and ... increased risk of severe acute pancreatitis in acute lymphoblastic leukemia patients treated with the chemotherapy agent ...
Cancer
Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and ... Traditional chemotherapeutic agents act by killing cells that divide rapidly, a critical property of most cancer cells. It was ... Radiation is a more potent source of cancer when combined with other cancer-causing agents, such as radon plus tobacco smoke. ...
Acute inhalation injury
... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Bleomycin is an antineoplastic antibiotic drug isolated in 1966 from the actinomycete Streptomyces verticillus. Bleomycin forms ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...
Gonadotropin-releasing hormone agonist
The agents nafarelin and triptorelin are agonists with single substitutions at position 6. Chemical structures of GnRH agonists ... Hormonal antineoplastic drugs, Gonadotropin-releasing hormone and gonadotropins, Progonadotropins). ...
ONCOS-102
While the ONCOS-102 oncolytic adenovirus has shown efficacy as a single agent against several soft tissue sarcomas, it would ... Antineoplastic and immunomodulating drug stubs, Virus stubs). ...
Interferon alfa-2b
brands, All stub articles, Antiinfective agent stubs, Antineoplastic and immunomodulating drug stubs). ... Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was ...
Panomifene
... of the triphenylethylene group related to tamoxifen that was under development as an antineoplastic agent by Egis ... Hormonal antineoplastic drugs, Trifluoromethyl compounds, Selective estrogen receptor modulators, Triphenylethylenes, All stub ...
Bivatuzumab mertansine
... is a combination of bivatuzumab, a humanized monoclonal antibody, and mertansine, a cytotoxic agent. It ... Antineoplastic and immunomodulating drug stubs). ...
Edelfosine
Houlihan, WJ; Lohmeyer M; Workman P; Cheon SH (1995). "Phospholipid antitumor agents". Medicinal Research Reviews. 15 (3): 157- ... It has antineoplastic (anti-cancer) effects. Like all ALPs, it incorporates into the cell membrane and does not target the DNA ... A Proapoptotic Agent in Tumor Cells". Current Drug Metabolism. 5 (3): 491-525. doi:10.2174/1389200023337225. hdl:10261/59536. ... "In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor ...
ESHAP
... a platinum-based antineoplastic agent, also an alkylating antineoplastic agent. ESHAP--an effective chemotherapy regimen in ...
Ketoconazole
Taken by mouth it is a less preferred option and only recommended for severe infections when other agents cannot be used. Other ... Hormonal antineoplastic drugs, Imidazole antifungals, Phenylethanolamine ethers, Janssen Pharmaceutica, Johnson & Johnson ... Tarbit MH, Robertson WR, Lambert A (1990). "Hepatic and Endocrine Effects of Azole Antifungal Agents". Chemotherapy of Fungal ... As with all azole antifungal agents, ketoconazole works principally by inhibiting the enzyme cytochrome P450 14α-demethylase ( ...
MINE (chemotherapy)
... an alkylating antineoplastic agent from oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue (anthraquinone ...
Erythroleukemia Medication: Antineoplastic agents
Antineoplastic Agents - Occupational Hazards in Hospitals | NIOSH | CDC
... and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. ... describe how you can be exposed to these agents, ... aware of the adverse health effects of antineoplastic agents, ... The purpose of this brochure is to make you aware of the adverse health effects of antineoplastic agents, describe how you can ... and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. ...
Gamma Heavy Chain Disease Medication: Antineoplastic Agents, Corticosteroids
It may be given as a single agent or as part of a multidrug treatment regimen; depending on protocol of choice, the dose and ... Chemotherapy is typically ineffective in γ-heavy chain disease (HCD). Agents that are effective in lymphoma and multiple ... Chlorambucil is a nitrogen-mustard alkylating agent, generally used for the treatment of chronic lymphocytic leukemia, ... Vincristine is a vesicant agent that blocks mitosis by arresting cells in metaphase. ...
NIOSHTIC-2 Publications Search - 20037544 - Development of an HPLC method for simultaneous analysis of five antineoplastic...
... be applied to both air and surface monitoring samples to provide a broader indication of risk to combinations of these agents. ... Simultaneous analysis of common antineoplastic agents potentially hazardous to healthcare workers is of much interest for the ... Drugs; Antineoplastic-agents; Hazardous-materials; Health-care-facilities; Health-care-personnel; Health-hazards; Occupational- ... Simultaneous analysis of common antineoplastic agents potentially hazardous to healthcare workers is of much interest for the ...
Long chain fatty alcohol substituents in antineoplastic agents - Patent EP-1465876-B1 - PubChem
Bullous Systemic Lupus Erythematosus (BSLE) Medication: Antimycobacterial Agents, Corticosteroids, Immunosuppressive Agents,...
Antineoplastics, Anti-CD20 Monoclonal Antibodies. Rituximab (Rituxan). *View full drug information. Rituximab is an anti-CD20 ... Antimycobacterial Agents. Class Summary. Therapy must be comprehensive and should cover all likely pathogens in the context of ... These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the ...
Subject: antineoplastic agents / Subject term: antineoplastic activity / Text Availability: Citation in PubAg - PubAg Search...
You searched for: Subject antineoplastic agents Remove constraint Subject: antineoplastic agents Subject term antineoplastic ... aldehydes; anti-infective agents; antibacterial properties; antineoplastic activity; antineoplastic agents; apoptosis; breast ... antineoplastic activity; antineoplastic agents; organic chemistry. Abstract:. ... The pyrimidine scaffold represents one of the ... X-radiation; antineoplastic activity; antineoplastic agents; drug therapy; radiolysis; radiotherapy. Abstract:. ... Precisely ...
Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate<...
Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. George Pettit, Matthew P. ... Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. Journal of Medicinal ... Antineoplastic agents. 465. Structural modification of resveratrol : Sodium resverastatin phosphate. In: Journal of Medicinal ... Pettit, G., Grealish, M. P., Jung, M. K., Hamel, E., Pettit, R., Chapuis, J., & Schmidt, J. M. (2002). Antineoplastic agents. ...
Immunology & Oncology - Pharmacology - Immunosuppressants & Antineoplastic Agents for Medicine
Pediatric Medulloblastoma Medication: Antineoplastic agents
These agents cause DNA damage and disrupt DNA replication. Most chemotherapy is given in the inpatient setting. Standard of ... Lomustine (CCNU), a nitrogen mustard and DNA alkylator used in combination with other chemotherapeutic agents. Acts by ... Cisplatin, a heavy metal platinum derivative used in combination with other chemotherapeutic agents. It exerts its cytotoxic ... Vincristine, a plant-derived vinca alkaloid used during radiotherapy and in combination with other chemotherapeutic agents. ...
Carcinoid Lung Tumors Medication: Antineoplastic Agents
ABT-199 & Ibrutinib in Mantle Cell Lymphoma (AIM) - Full Text View - ClinicalTrials.gov
Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross...
Antineoplastic Agents / analysis* * Antineoplastic Agents / urine* * Biomarkers / urine * Cross-Sectional Studies * ... Introduction: Antineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. Healthcare professionals are ... Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross- ...
Antineoplastic And Immunomodulating Agents
Antineoplastic Agent - Generic online medicine
Antineoplastic Agent, BodyBuilding, Estrogen Receptor Antagonist, Selective Estrogen Receptor Modulator. Cytotam (Nolvadex)20 ... Antineoplastic Agent, BodyBuilding, Estrogen Receptor Antagonist, Selective Estrogen Receptor Modulator. Cytotam (Nolvadex)10 ... Acne, Acne Products, Antineoplastic Agent, Retinoic Acid Derivatives, Vitamin A Derivative. Tretiva (Accutane)20 Mg - 10 tablet ... Acne, Acne Products, Antineoplastic Agent, Retinoic Acid Derivatives, Vitamin A Derivative. Tretiva (Accutane)10 Mg - 10 tablet ...
Leukeran
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Antineoplastic Agents, ATC:L01AA02
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating ... Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the ... agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in ...
Minimal-Change Disease Medication: Diuretics, Corticosteroids, Antineoplastic agents, Immunosuppressant agents, Immunomodulators
Details for: Some antineoplastic and immunosuppressive agents / › WHO HQ Library catalog
Antineoplastic agents -- toxicity , Immunosuppressive agents -- toxicityNLM classification: QZ 202 Tags from this library: No ... Some antineoplastic and immunosuppressive agents / this publication represents the views and expert opinions of an IARC Working ... some Antineoplastic and Immunosuppressive Agents (1980: Lyon, France)Contributor(s): International Agency for Research on ...
Search of: mesothelioma AND Mesothelioma | Recruiting, Not yet recruiting, Available Studies | Last update posted in the last...
Global Antineoplastic Agents Market, Analysis, Size, Share, Trends, COVID-19 Impact, and Forecast 2022 2029
Global Antineoplastic Agents Market, Analysis, Size, Share, Trends, COVID-19 Impact, and Forecast 2022 2029 By Type (Type I, ... The global Antineoplastic Agents Market report discusses different scenarios of the Antineoplastic Agents Market and offers a ... The global Antineoplastic Agents market was valued at US$ XX Billion in 2021 and is projected to reach US$ Antineoplastic ... Latin America Antineoplastic Agents Market, Overview, Size, and Forecast. 8.4.1. Brazil 8.4.2. Argentina. 8.4.3. Rest of Latin ...
Results of search for 'ccl=su:{Antineoplastic agents}' › WHO HQ Library catalog
Utilization of metabolic activation for in vitro screening of potential antineoplastic agents<...
Meltz, M. L. ; Winters, D. W. / Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. ... Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. / Meltz, M. L.; Winters, D. W. ... Meltz, ML & Winters, DW 1979, Utilization of metabolic activation for in vitro screening of potential antineoplastic agents, ... Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. Cancer Treatment Reports. 1979; ...
Phyto-Facilitated Bimetallic ZnFe2O4 Nanoparticles via Boswellia carteri: Synthesis, Characterization, and Anti-Cancer Activity
Antineoplastic Agents, Phytogenic / chemistry * Antineoplastic Agents, Phytogenic / isolation & purification * Antineoplastic ... Background: The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop ... and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the ...
Anti-neoplastic agents (Med Chem:- 2) Notes Download - Remix education
Anti-neoplastic agents (Med Chem:- 2) Notes Download. by Mihir jesur. December 19, 2021. December 19, 2021. 0589 ... Many of these agents act on dividing and resting cells, and thus are cell cycle -non-specific. Some o f these agents show CNS ... ClassificationThe anti-neoplastic agents are classified as follows:1) Alkylating agentsNitrogen mustards Mechlorethamine ( ... Alkylating agents are chemically reactive compounds. It combines most easily with nucleophilic centres, and a fully saturated ...
IMSEAR at SEARO: Approval of antineoplastic agents in India: comparison with the US and EU regions.
The US was the first to approve 59 (84.28%) out of the 70 new antineoplastic agents, the EU was the first to approve 9 (12.85 ... The present study was undertaken to assess the drug lag for new antineoplastic agents in India compared with that in the United ... Kataria Bhaven C, Mehta Dimple S, Chhaiya Sunita B. Approval of antineoplastic agents in India: comparison with the US and EU ... We assessed absolute and relative drug lag for new antineoplastic agents approved in the three regions. Results: Of the 70 new ...
Principles of Pediatric Environmental Health: How Can Parents' Preconception Exposures and In Utero Exposures Affect a...
In a study of nurses and pharmacists with occupational exposure to antineoplastic agents, maternal exposure to antineoplastic ... Agents that interfere with the menstrual cycle and ovulation, such as hormonally active agents, may affect fertility [Windham ... Antineoplastic drugs. Miscarriage, low birth weight, birth defects. Certain ethylene glycol ethers such as 2-ethoxyethanol (2EE ... Agents that interfere with male hormones or with hormonal feedback (e.g., testosterone, luteinizing hormone [LH]) may also ...
Treatment of Marburg Variant Multiple Sclerosis with Mitoxantrone | Semantic Scholar
Quimio em casa: application for family members of children and adolescents using oral antineoplastic agents | Texto & contexto...
Quimio em casa: application for family members of children and adolescents using oral antineoplastic agents / Quimio en casa: ... specific care for each chemotherapy agent, adverse effects, when to go to the emergency room and daily checking of ... mobile application for the guidance of family members of children and adolescents undergoing treatment with oral antineoplastic ...
Immunomodulating Agents1
- ATC code L: Antineoplastic and immunomodulating agents is a section of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. (profarma.al)
20202
- The COVID-19 pandemic has significantly affected the global Antineoplastic Agents market in 2020. (globalmarketvision.com)
- De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. (mitophysiology.org)
Alkylating10
- Chlorambucil is a nitrogen-mustard alkylating agent, generally used for the treatment of chronic lymphocytic leukemia, Waldenstrom macroglobulinemia, and as a second- or third-line therapy for patients with lymphomas. (medscape.com)
- Acts similarly to alkylating agents by crosslinking DNA and inhibiting DNA replication. (medscape.com)
- Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. (pharmacycode.com)
- Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. (pharmacycode.com)
- Alkylating agents are cell cycle-nonspecific. (pharmacycode.com)
- Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. (pharmacycode.com)
- Alkylating agents are chemically reactive compounds. (remixeducation.in)
- from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
- ed tissues, the intensity of which and chemical alkylating agents are varies with the degree of antigenic considered to cause cancer primar- Immunosuppressive difference between graft and host. (who.int)
- An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
Potential antineoplastic2
- Meltz, ML & Winters, DW 1979, ' Utilization of metabolic activation for in vitro screening of potential antineoplastic agents ', Cancer Treatment Reports , vol. 63, no. 11-12, pp. 1795-1801. (uthscsa.edu)
- LY2801653 , also known as Merestinib, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. (newdrugapprovals.org)
Chemotherapy6
- The contents that guided the application development were storage, handling, administration , specific care for each chemotherapy agent, adverse effects , when to go to the emergency room and daily checking of administrations. (bvsalud.org)
- 3 Whereas hazardousdrugs include a variety ofagents?among them cancer chemotherapy,antiviral drugs, and hormones?the ASHP/OSHA definition may not accuratelyreflect the hazardous risks ofmore-recent agents. (pharmacytimes.com)
- Purpose Novel antitumor therapies against the PI3K-AKT-mTOR pathway are increasingly used to treat cancer, either as single agents or in combination with chemotherapy or other targeted therapies. (icr.ac.uk)
- This should be taken into consideration during the design and conduct of trials involving PI3K-AKT-mTOR pathway inhibitors, particularly when combined with chemotherapy or myelosuppressive agents. (icr.ac.uk)
- As certain cytotoxic antineoplastic agents, such as anthracyclines, generate reactive oxygen species as a by-product of their mechanism of action, we examined whether redox protein expression was involved in the response to anthracycline-based chemotherapy and with clinical outcome. (nottingham.ac.uk)
- Although many cancers can be treated efficiently in first line chemotherapy, relapse and refractory cancers require the discovery and development of new anti cancer agents. (univie.ac.at)
Cytotoxic1
- IntroductionAlkylating agents exert cytotoxic and radiomimetic actions. (remixeducation.in)
Anticancer2
- Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. (usda.gov)
- The lifetime when appropriate levels of its application in anticancer chemo- Group 1 agents that act by immuno- immunosuppression are maintained. (who.int)
Vinca1
- Vincristine, a plant-derived vinca alkaloid used during radiotherapy and in combination with other chemotherapeutic agents. (medscape.com)
Drugs6
- Antineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. (nih.gov)
- therefore, a drug lag in the availability of antineoplastic drugs is a direct threat to life. (who.int)
- to develop and validate a mobile application for the guidance of family members of children and adolescents undergoing treatment with oral antineoplastic drugs . (bvsalud.org)
- Hydroxyurea belongs to a group of drugs called antineoplastic agents. (rxwiki.com)
- Exposure to hazardous agents canoccur during the preparation, administration,or disposal of these drugs whenhealth care workers create aerosols,generate dust, clean up spills, or touchcontaminated surfaces. (pharmacytimes.com)
- Adverse effects of hazardous drugsthrough occupational exposure werefirst reported nearly 30 years ago, whenan increased incidence of genotoxicitywas documented in pharmacists andnurses handling antineoplastic drugs. (pharmacytimes.com)
20191
- The global Antineoplastic Agents Market report discusses different scenarios of the Antineoplastic Agents Market and offers a comprehensive analysis of historical data (2016-2019), providing a detailed study on emerging trends and strategic decisions businesses take to gain adequate growth in the global market. (globalmarketvision.com)
Antibiotics1
- Peptide transporters display a remarkable capacity to recognise a diverse library of di‐ and tri-peptides, making them extremely promiscuous and major contributors to the pharmacokinetic profile of several important drug classes, including beta-lactam antibiotics, anti-viral and antineoplastic agents. (biorxiv.org)
Oral3
- validación con doce familiares de niños y adolescentes en quimioterapia oral y adaptación final de la aplicación móvil. (bvsalud.org)
- se devolvió la aplicación "Quimio em Casa" con dos interfaces, una versión de escritorio dirigida a profesionales de la salud y la aplicación para familiares de niños y adolescentes en tratamiento con quimioterapia oral. (bvsalud.org)
- la aplicación demostró ser válida como tecnología educativa en aplicación práctica con familiares de niños y adolescentes en quimioterapia oral. (bvsalud.org)
Oncology2
- Ils proviennent, notamment, de la British Columbia Cancer Agency (BCCA), de l'European Society of Medical Oncology (ESMO) en collaboration avec l'European Oncology Nursing Society (EONS), du Gippsland Oncology Nurses Group (GONG), du Humber and Yorkshire Coast Cancer Network (HYCCN), de l'Oncology Nursing Society (ONS) et du West of Scotland Cancer Advisory Network Clinical Leads Group (WOSCAN). (bvsalud.org)
- Drug interactions between antineoplastic and antidepressant agents analysis of patients seen at an oncology clinic at a general hospital. (bvsalud.org)
20213
- Global Market Vision offers the report on Global Antineoplastic Agents Market Analysis and Forecast 2021-2029. (globalmarketvision.com)
- The global Antineoplastic Agents market was valued at US$ XX Billion in 2021 and is projected to reach US$ Antineoplastic Agents. (globalmarketvision.com)
- Global Market Vision provides an analysis of the key segment and each sub-segment of the global Antineoplastic Agents market, along with forecasts at the global, regional, and country levels from 2021-2027. (globalmarketvision.com)
19801
- Some antineoplastic and immunosuppressive agents / this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, which met in Lyon, 14-21 October 1980. (who.int)
Cancer4
- The approach used to select the five agents was to obtain a list of the agents used most frequently in both a cancer hospital and an outpatient cancer treatment center, then review the list to determine which agents were potentially more hazardous to human health. (cdc.gov)
- The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop new methods for obtaining materials with more effective and safe anti-cancer properties. (nih.gov)
- L'objectif est de faire état de la documentation scientifique pertinente concernant la prise en charge et le traitement de l'extravasation survenue au cours de l'administration de chimiothérapie à des patients atteints de cancer. (bvsalud.org)
- The primary endpoint of the study is overall survival, and secondary endpoints include time to castration-resistant prostate cancer, time to initiation of subsequent antineoplastic therapy, symptomatic skeletal event free survival (SSE-FS), time to first symptomatic skeletal event (SSE), time to initiation of opioid use, time to pain progression, time to worsening of physical symptoms of disease and safety. (salesandmarketingnetwork.com)
Inhibitors1
- P = 0.03) infection when compared with single-agent PI3K-AKT-mTOR inhibitors.Conclusions Inhibitors of the PI3K-AKT-mTOR pathway can be associated with a higher risk of infection. (icr.ac.uk)
Vincristine1
- Vincristine is a vesicant agent that blocks mitosis by arresting cells in metaphase. (medscape.com)
Methods4
- The purpose of this brochure is to make you aware of the adverse health effects of antineoplastic agents, describe how you can be exposed to these agents, and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. (cdc.gov)
- To overcome the obstacles of traditional physical and chemical methods for the synthesis of such nanoparticles, a new, less expensive, and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the desired metallic nanoparticles from their precursors, a process called green biosynthesis of nanoparticles. (nih.gov)
- Methods: The new antineoplastic agents approved in the United States, European Union and India between 1999 and 2011 were identified and information was gathered primarily from the websites of regulatory agencies of the three regions. (who.int)
- METHODS: We created an agent-based model representing the Chicago population and conducted experiments to determine the effects of varying adult out-of-household activities (OOHA), school reopening, and protective behaviors across age groups on COVID-19 transmission and hospitalizations. (bvsalud.org)
Approval2
Hormonal2
- Agents that interfere with male hormones or with hormonal feedback (e.g., testosterone, luteinizing hormone [LH]) may also affect production of healthy sperm, thus affecting fertility [Osorio and Windham 2004]. (cdc.gov)
- Nilutamide: possible utility as a second-line hormonal agent. (uchicago.edu)
Carcinoma1
- This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. (usda.gov)
Treatment6
- Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. (scielo.br)
- These agents have been shown to be beneficial in the treatment of linear IgA dermatosis. (medscape.com)
- Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
- Imatinib-associated lichenoid eruption: acitretin treatment allows maintained antineoplastic effect. (web.app)
- The treatment options include no treatment and treatment with a low- to mid-potency topical corticosteroid (alone or in combination with a keratolytic agent). (web.app)
- In the United States topical aminolevulinic acid (ALA) is approved as a photosensitizing agent for this treatment, and it has traditionally been activated with the use of an in-office artificial light source. (trialbulletin.com)
Chemotherapeutic agents2
- Lomustine (CCNU), a nitrogen mustard and DNA alkylator used in combination with other chemotherapeutic agents. (medscape.com)
- Cisplatin, a heavy metal platinum derivative used in combination with other chemotherapeutic agents. (medscape.com)
Sodium1
- L'utilisation du diméthylsulfoxide (DMSO), de la dexrazoxane, de l'hyaluronidase ou du thiosulfate de sodium est recommandée selon l'agent en cause de l'extravasation. (bvsalud.org)
Clinical1
- These agents are used to improve the clinical and immunologic aspects of the disease. (medscape.com)
Assess1
- The present study was undertaken to assess the drug lag for new antineoplastic agents in India compared with that in the United States (US) or European Union (EU). (who.int)
Hazardous agents1
- It was determined that the ability to simultaneously evaluate five frequently used, potentially hazardous agents was sufficient for general evaluation of exposures to healthcare workers. (cdc.gov)
Lymphoma1
- Agents that are effective in lymphoma and multiple myeloma have generally been used, but results have been disappointing. (medscape.com)
Metabolic1
- These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)