Antineoplastic agents. Medical search

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.

A plant genus of the family LILIACEAE. Members contain ungiminorine and LECTINS.

Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.

Compounds with 1,2-diphenylethane. They are structurally like reduced STILBENES.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.

Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

The action of a drug in promoting or enhancing the effectiveness of another drug.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Acridines which are substituted in any position by one or more amino groups or substituted amino groups.

A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).

A cell line derived from cultured tumor cells.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.

Antimetabolites that are useful in cancer chemotherapy.

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Organic compounds that contain 1,2-diphenylethylene as a functional group.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Tumors or cancer of the LUNG.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)

Experimental transplantation of neoplasms in laboratory animals for research purposes.

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

Tumors or cancer of the human BREAST.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Elements of limited time intervals, contributing to particular results or situations.

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Established cell cultures that have the potential to propagate indefinitely.

The rate dynamics in chemical or physical systems.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Tumors or cancer of the COLON.

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.

Tumors or cancer of the PROSTATE.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.

A plant genus of the family ASTERACEAE. This plant should not be confused with microtubule asters (MICROTUBULES) nor with aster yellows phytoplasma (mycoplasma-like organisms).

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.

A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Individuals responsible for various duties pertaining to the medical office routine.

A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.

Functions and activities of DENTITION as a whole.

Any materials used in providing care specifically in the hospital.

Clothing designed to protect the individual against possible exposure to known hazards.

The presence of an infectious agent on instruments, prostheses, or other inanimate articles.

An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.

The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.

Inorganic compounds that contain vanadium as an integral part of the molecule.

Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).

Personnel who provide nursing service to patients in a hospital.

The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.

Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.

The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

The individuals employed by the hospital.

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)

An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Clinical protocols used to inhibit the growth or spread of NEOPLASMS.

A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.

Facilities for the preparation and dispensing of drugs.

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

Simultaneous resistance to several structurally and functionally distinct drugs.

An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.

The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.

A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.

A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.

Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Institutions with an organized medical staff which provide medical care to patients.

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Compounds that inhibit the activity of DNA TOPOISOMERASE I.

A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.

The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Those persons legally qualified by education and training to engage in the practice of pharmacy.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

Keto-pyrans.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.

Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.

Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)

A group of compounds that contain the structure SO2NH2.

DNA present in neoplastic tissue.

A general term for various neoplastic diseases of the lymphoid tissue.

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

An antimitotic agent with immunosuppressive properties.

Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

Organic compounds which contain platinum as an integral part of the molecule.

A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.

A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

An alkylating agent of value against both hematologic malignancies and solid tumors.

A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.

The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.

Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.

Institutions specializing in the care of cancer patients.

Electronic volume analysis of L1210 chemotherapy. (1/35913)

The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 X DBA/2F1 mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents. 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-beta-D-arabinofuranosylcytosine, vincristine, and methotrexate. (+info)

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (2/35913)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (3/35913)

The Mdm2 protein is frequently overexpressed in human non-seminomatous germ cell tumours and transitional carcinoma of the bladder where it may contribute to tolerance of wtp53. Mdm2 forms an autoregulatory feedback loop with p53; the Mdm2 gene is responsive to transactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response. We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. Rapid apoptosis ensues. Global transcription is not inhibited: p21waf-1/cip1 and GADD45 expression increase in a dose dependent manner. Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. Downregulation of Mdm2 transcript occurs in cells expressing HPV16-E6 suggesting that inhibition of Mdm2 transcription is p53-independent. When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment conditions. This is the first observation of inhibition of Mdm2 transcription following treatment with topoisomerase (topo II) poisons, a feature that may be useful in tumour types where p53 is tolerated by overexpression of Mdm2. (+info)

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (4/35913)

Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera. (+info)

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (5/35913)

Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line U266. Moreover, U266 cells are inherently resistant to Fas-mediated apoptosis and express high levels of the antiapoptotic protein Bcl-xL. Blocking IL-6 receptor signaling from Janus kinases to the Stat3 protein inhibits Bcl-xL expression and induces apoptosis, demonstrating that Stat3 signaling is essential for the survival of myeloma tumor cells. These findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. (+info)

Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. (6/35913)

Cellular and molecular mechanisms involved in the resistance to cytotoxic heavy metals remain largely to be characterized in mammalian cells. To this end, we have analyzed a metal-resistant variant of the human lung cancer GLC4 cell line that we have selected by a step-wise procedure in potassium antimony tartrate. Antimony-selected cells, termed GLC4/Sb30 cells, poorly accumulated antimony through an enhanced cellular efflux of metal, thus suggesting up-regulation of a membrane export system in these cells. Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays. Moreover, MK571, a potent inhibitor of MRP1 activity, was found to markedly down-modulate resistance of GLC4/Sb30 cells to antimony and to decrease cellular export of the metal. Taken together, our data support the conclusion that overexpression of functional MRP1 likely represents one major mechanism by which human cells can escape the cytotoxic effects of heavy metals. (+info)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (7/35913)

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8-7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. (+info)

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (8/35913)

Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise. (+info)

An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to ... The platinum agents are also sometimes described as nonclassical. Alkylating antineoplastic agents have limitations. Their ... List of hormonal cytostatic antineoplastic agents "Alkylating Agents". US National Library of Medicine. Archived from the ... Many of the agents are known as "classical alkylating agents". These include true alkyl groups, and have been known for a ...

https://en.wikipedia.org/wiki/Alkylating_antineoplastic_agent

This is a list of antineoplastic agents used to treat cancer. Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). ...

https://en.wikipedia.org/wiki/List_of_antineoplastic_agents

... (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or ... Alkylating antineoplastic agent and anthracyclins are two examples. "Chemotherapy: The Basics". OncoLink. Archived from the ... "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer ...

https://en.wikipedia.org/wiki/Cell-cycle_nonspecific_antineoplastic_agents

This is a list of dual hormonal and cytostatic antineoplastic agents. Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC- ... Antineoplastic drugs, Hormonal antineoplastic drugs, Nitrogen mustards). ...

https://en.wikipedia.org/wiki/List_of_hormonal_cytostatic_antineoplastic_agents

"Antineoplastic agents. 47. Structure of an antineoplastic agent from Streptomyces griseoluteus". Journal of the American ...

https://en.wikipedia.org/wiki/Streptomyces_griseoluteus

"Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine ... "Antineoplastic agents. 257. Isolation and structure of spongistatin 1". Journal of Organic Chemistry. 58 (6): 1302-1304. doi: ...

https://en.wikipedia.org/wiki/John_Hooper_(marine_biologist)

The bulbs of N. poeticus contain the antineoplastic agent narciclasine. This usage is also found in later Arabian, North ... Pettit, GR; Cragg, GM; Singh, SB; Duke, JA; Doubek, DL (1990). "Antineoplastic agents, 162. Zephyranthes candida". Journal of ... "Antineoplastic Agents. 587. Isolation and Structure of 3-Epipancratistatin from Narcissus cv. Ice Follies". Journal of Natural ... as Potential Anticancer Agents". Journal of Medicinal Chemistry. 52 (4): 1100-1114. doi:10.1021/jm8013585. PMID 19199649. ...

https://en.wikipedia.org/wiki/Narcissus_(plant)

Pettit GR, Xu JP, Chapuis JC, Pettit RK, Tackett LP, Doubek DL, Hooper JN, Schmidt JM (2004). "Antineoplastic agents. 520. ...

https://en.wikipedia.org/wiki/Psymberin

Pettit, G. R.; Gaddamidi, V.; Goswami, A.; Cragg, G. M. (1984). "Antineoplastic agents,99. Amaryllis beladonna". Journal of ...

https://en.wikipedia.org/wiki/Amaryllis

Certain antineoplastic agents, bryostatins 4 and 5, have been extracted from Aplidium californicum and are being evaluated. ... Pettit GR, Leet JE, Herald CL, Kamano Y, Doubek DL (1986). "Antineoplastic agents, 116. An evaluation of the marine ascidian ...

https://en.wikipedia.org/wiki/Aplidium_californicum

Pettit GR, Cragg GM, Singh SB (May-June 1987). "Antineoplastic agents, 122. Constituents of Combretum caffrum". Journal of ...

https://en.wikipedia.org/wiki/Combretum_caffrum

"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...

https://en.wikipedia.org/wiki/Prednisone

ISBN 978-3-642-99941-3. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. ... Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Halogenated ... Carpenter JT (1988). "Progestational agents in the treatment of breast cancer". Cancer Treat. Res. Cancer Treatment and ... Hormonal antineoplastic drugs, Organobromides, Pregnanes, Progestogens, Triketones). ...

https://en.wikipedia.org/wiki/Bromoketoprogesterone

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Nathanson ... 549-. ISBN 978-3-642-30725-6. The first sex steroid used as pharmacological agent was Progynon, first sold by Schering AG in ...

https://en.wikipedia.org/wiki/Estrogen_(medication)

Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp ...

https://en.wikipedia.org/wiki/Allenolic_acid

31-. ISBN 978-1-4613-2157-6. Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer ...

https://en.wikipedia.org/wiki/Estriol

83-. ISBN 978-1-4832-7299-3. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents ...

https://en.wikipedia.org/wiki/Dimethylstilbestrol

Sartorelli, Alan C.; Johns, David G. (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & ... Anthramycin is an active anti-tumor agent and antibiotic. It works by inhibiting the synthesis of RNA and DNA of carcinoma ...

https://en.wikipedia.org/wiki/Anthramycin

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Crowley, ... Geller J, Fruchtman B, Newman H, Roberts T, Silva R (February 1967). "Effect of progestational agents on carcinoma of the ... Hall NR (June 2011). "What agent should be used to prevent recurrent preterm birth: 17-P or natural progesterone?". Obstetrics ... In the group of new parenteral progestational agents, three substances developed by Karl Junkmann1,2 are the most outstanding ...

https://en.wikipedia.org/wiki/Hydroxyprogesterone_caproate

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. ... Hormonal antineoplastic drugs, Human drug metabolites, Organofluorides, All stub articles, Steroid stubs, Genito-urinary system ...

https://en.wikipedia.org/wiki/Oxofluoxymesterone

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Oxylone ... ISBN 978-3-88763-075-1. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and ... Hormonal antineoplastic drugs, Progestogens, All stub articles, Steroid stubs, Genito-urinary system drug stubs). ...

https://en.wikipedia.org/wiki/Fluorometholone_acetate

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Council on ... However, androstanolone is nonetheless described as a very poor anabolic agent. This is attributed to its high affinity as a ... von Deutsch DA, Abukhalaf IK, Lapu-Bula R (15 October 2003). "Anabolic Doping Agents". In Mozayani A, Raymon L (eds.). Handbook ... 63-. ISBN 978-3-88763-075-1. Morton I, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and ...

https://en.wikipedia.org/wiki/Androstanolone

ISBN 978-0-323-13916-8. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents. ...

https://en.wikipedia.org/wiki/Doisynolic_acid

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. Li JJ (3 ... 219-. ISBN 978-3-88763-075-1. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties ... Hormonal antineoplastic drugs, Organochlorides, Phenol ethers, Prodrugs, Progonadotropins, Selective estrogen receptor ...

https://en.wikipedia.org/wiki/Chlorotrianisene

Antineoplastic and Immunosuppressive Agents. pp. 170-192. doi:10.1007/978-3-642-65806-8_11. ISBN 978-3-642-65806-8. v t e v t e ... Hormonal antineoplastic drugs, Prodrugs, World Anti-Doping Agency prohibited substances, All stub articles, Steroid stubs, ...

https://en.wikipedia.org/wiki/Androstenediol_diacetate

31-. ISBN 978-1-4613-2157-6. Alan C. Sartorelli; David G. Johns (27 November 2013). Antineoplastic and Immunosuppressive Agents ... I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ...

https://en.wikipedia.org/wiki/Estriol_(medication)

"antineoplastic agent (CHEBI:35610)". www.ebi.ac.uk. Retrieved 2019-10-26.{{cite web}}: CS1 maint: url-status (link) "1- ... It has the role of antineoplastic agent, which means it can inhibit or prevent the neoplasms' proliferation. It is also the ...

https://en.wikipedia.org/wiki/1-Deoxysphingolipids

Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 181-. ISBN 978-3-642-65806-8. Heinrich Kahr ...

https://en.wikipedia.org/wiki/List_of_sex-hormonal_aqueous_suspensions

It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA ... O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was ... Antineoplastic drugs, Experimental cancer drugs, Benzyl compounds). ...

https://en.wikipedia.org/wiki/O6-Benzylguanine

Milne GW (1 July 2000). Ashgate Handbook of Antineoplastic Agents. Wiley. p. 5. ISBN 978-0-566-08382-2. Tripathi KD (30 ... List of hormonal cytostatic antineoplastic agents List of estrogen esters § Estradiol esters NCI Thesaurus. "Alestramustine". ... is a cytostatic antineoplastic agent which was never marketed. It is the L-alanine ester of estramustine, which is a ... Antineoplastic drugs, Chloroethyl compounds, Estradiol esters, Estranes, Hormonal antineoplastic drugs, Nitrogen mustards, ...

https://en.wikipedia.org/wiki/Alestramustine

Most of those components are antitumor agents and anthracycline antibiotics active against Gram-positive bacteria. Bohemic acid ... "The Toxicologic Evaluation of Marcellomycin-An Antineoplastic Anthracycline Antibiotic". Drug and Chemical Toxicology. 6 (1): ... Subscription or participating institution membership required.) "Antitumor agents from the bohemic acid complex. 4. Structures ... "Antitumor Agents from Bohemic Acid Complex, VI. Schaunardimycin". Journal of Natural Products. 47 (4): 698-701. doi:10.1021/ ...

https://en.wikipedia.org/wiki/Bohemic_acid

One such analog, known as Ixabepilone is a U.S. Food and Drug Administration approved chemotherapy agent for the treatment of ... Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity. This has led ... Myxobacteria are also known to produce gephyronic acid, an inhibitor of eukaryotic protein synthesis and a potential agent for ...

https://en.wikipedia.org/wiki/Myxobacteria

Now little-used due to high incidence of elevated liver enzymes and hepatotoxicity and the availability of safer agents. ... Hormonal antineoplastic drugs, Progonadotropins, Prostate cancer, Sex hormones). ... Kaur P, Khatik GL (2016). "Advancements in Non-steroidal Antiandrogens as Potential Therapeutic Agents for the Treatment of ...

https://en.wikipedia.org/wiki/Nonsteroidal_antiandrogen

Tissue agnostic antineoplastic agents). ...

https://en.wikipedia.org/wiki/Selpercatinib

... s are different from anticarcinoma agents (also known as anticancer or anti-neoplastic agents) in that ... Chemopreventive agents, All stub articles, Antineoplastic and immunomodulating drug stubs). ... An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or ... v t e (All articles with unsourced statements, Articles with unsourced statements from June 2017, Antineoplastic drugs, ...

https://en.wikipedia.org/wiki/Anticarcinogen

The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is ... Antineoplastic drugs, Cancer research, Enediynes, Epoxides, Carbonate esters, Experimental cancer drugs, Naphthalenes, Nine- ...

https://en.wikipedia.org/wiki/Neocarzinostatin

brands, Monoclonal antibodies for tumors, Orphan drugs, Tissue agnostic antineoplastic agents, World Health Organization ... agents targeting those mutations should be used first. Assessment of PD-L1 expression must be conducted with a validated and ... in people whose tumors express PD-L1 and who have failed treatment with other chemotherapeutic agents. In July 2016, the US FDA ... for all patients and as a single agent for patients whose tumors express PD‑L1 (Combined Positive Score [CPS] ≥1) as determined ...

https://en.wikipedia.org/wiki/Pembrolizumab

... of Cdc25 could also be useful for the arrest of cell cycle and therefore be useful as antineoplastic and anticancer agents. ... ISBN 978-0-12-324719-3. "Presentation on CDC25 PHOSPHATASES: A Potential Target for Novel Anticancer Agents". Archived from the ...

https://en.wikipedia.org/wiki/Cell_cycle

Kanimoto Y, Okada K (November 1991). "[Antiandrogen therapy of benign prostatic hyperplasia--review of the agents evaluation of ... Hormonal antineoplastic drugs, Obstetric drugs, Prodrugs, Progestogens). ... Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science ... The preventive effect of indeloxazine hydrochloride to the sexual dysfunction caused by anti-androgenergic agent (allylestrenol ...

https://en.wikipedia.org/wiki/Allylestrenol

... is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. ...

https://en.wikipedia.org/wiki/Nocodazole

Hormonal antineoplastic drugs, Indoles, Piperidines, Selective estrogen receptor modulators, All stub articles, Antineoplastic ... 14-. ISBN 978-3-642-15732-5. Prudhomme M (14 June 2013). Advances in Anticancer Agents in Medicinal Chemistry. Bentham Science ...

https://en.wikipedia.org/wiki/Pipendoxifene

Subgroup L04 is part of the anatomical group L Antineoplastic and immunomodulating agents. Codes for veterinary use (ATCvet ...

https://en.wikipedia.org/wiki/ATC_code_L04

List of hormonal cytostatic antineoplastic agents List of estrogen esters J. Elks (14 November 2014). The Dictionary of Drugs: ... nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of ... Antineoplastic drugs, Estrogen esters, Hormonal antineoplastic drugs, Carbamates, Phenols, Synthetic estrogens, Chloroethyl ... compounds, All stub articles, Antineoplastic and immunomodulating drug stubs, Genito-urinary system drug stubs). ...

https://en.wikipedia.org/wiki/ICI-85966

Other hazardous agents can affect the overall health of the woman and reduce the delivery of nutrients to the fetus. Radiation ... "Antineoplastic (Chemotherapy) Drugs - Reproductive Health , NIOSH , CDC". www.cdc.gov. 2022-02-02. Retrieved 2022-03-17. " ... "Infectious Agents - Reproductive Health , NIOSH , CDC". www.cdc.gov. 2021-11-17. Retrieved 2022-03-17. "Lead & Other Heavy ... Hazards that can reduce fertility in women include: cancer treatment drugs, including antineoplastic drugs lead ionizing ...

https://en.wikipedia.org/wiki/Sexual_and_reproductive_health

Anti-inflammatory agents, Benzofurans, Fluoroarenes, Immunosuppressants, Quinolines, Selective glucocorticoid receptor ... modulators, Trifluoromethyl compounds, All stub articles, Musculoskeletal system drug stubs, Antineoplastic and ...

https://en.wikipedia.org/wiki/Mapracorat

Hormonal antineoplastic drugs, Phenols, Piperidines, Selective estrogen receptor modulators, All stub articles, Antineoplastic ... Acolbifene/prasterone List of investigational sex-hormonal agents § Estrogenics Gauthier S, Cloutier J, Dory YL, Favre A, ...

https://en.wikipedia.org/wiki/Acolbifene

In her research, she focused on antineoplastic PK and PD in children, pharmacogenetics of antileukemia therapy and host- and ... increased risk of severe acute pancreatitis in acute lymphoblastic leukemia patients treated with the chemotherapy agent ...

https://en.wikipedia.org/wiki/Mary_V._Relling

Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and ... Traditional chemotherapeutic agents act by killing cells that divide rapidly, a critical property of most cancer cells. It was ... Radiation is a more potent source of cancer when combined with other cancer-causing agents, such as radon plus tobacco smoke. ...

https://en.wikipedia.org/wiki/Cancer

... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Bleomycin is an antineoplastic antibiotic drug isolated in 1966 from the actinomycete Streptomyces verticillus. Bleomycin forms ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

The agents nafarelin and triptorelin are agonists with single substitutions at position 6. Chemical structures of GnRH agonists ... Hormonal antineoplastic drugs, Gonadotropin-releasing hormone and gonadotropins, Progonadotropins). ...

https://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone_agonist

While the ONCOS-102 oncolytic adenovirus has shown efficacy as a single agent against several soft tissue sarcomas, it would ... Antineoplastic and immunomodulating drug stubs, Virus stubs). ...

https://en.wikipedia.org/wiki/ONCOS-102

brands, All stub articles, Antiinfective agent stubs, Antineoplastic and immunomodulating drug stubs). ... Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was ...

https://en.wikipedia.org/wiki/Interferon_alfa-2b

... of the triphenylethylene group related to tamoxifen that was under development as an antineoplastic agent by Egis ... Hormonal antineoplastic drugs, Trifluoromethyl compounds, Selective estrogen receptor modulators, Triphenylethylenes, All stub ...

https://en.wikipedia.org/wiki/Panomifene

... is a combination of bivatuzumab, a humanized monoclonal antibody, and mertansine, a cytotoxic agent. It ... Antineoplastic and immunomodulating drug stubs). ...

https://en.wikipedia.org/wiki/Bivatuzumab_mertansine

Houlihan, WJ; Lohmeyer M; Workman P; Cheon SH (1995). "Phospholipid antitumor agents". Medicinal Research Reviews. 15 (3): 157- ... It has antineoplastic (anti-cancer) effects. Like all ALPs, it incorporates into the cell membrane and does not target the DNA ... A Proapoptotic Agent in Tumor Cells". Current Drug Metabolism. 5 (3): 491-525. doi:10.2174/1389200023337225. hdl:10261/59536. ... "In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor ...

https://en.wikipedia.org/wiki/Edelfosine

... a platinum-based antineoplastic agent, also an alkylating antineoplastic agent. ESHAP--an effective chemotherapy regimen in ...

https://en.wikipedia.org/wiki/ESHAP

Taken by mouth it is a less preferred option and only recommended for severe infections when other agents cannot be used. Other ... Hormonal antineoplastic drugs, Imidazole antifungals, Phenylethanolamine ethers, Janssen Pharmaceutica, Johnson & Johnson ... Tarbit MH, Robertson WR, Lambert A (1990). "Hepatic and Endocrine Effects of Azole Antifungal Agents". Chemotherapy of Fungal ... As with all azole antifungal agents, ketoconazole works principally by inhibiting the enzyme cytochrome P450 14α-demethylase ( ...

https://en.wikipedia.org/wiki/Ketoconazole

... an alkylating antineoplastic agent from oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue (anthraquinone ...

https://en.wikipedia.org/wiki/MINE_(chemotherapy)

Antineoplastic agents. Class Summary. Antineoplastic agents are used for induction or consolidation therapy. They include ... Myelodysplastic Syndromes Following Therapy with Hypomethylating Agents (HMAs): Development of Acute Erythroleukemia May Not ...

https://www.medscape.com/answers/199965-168332/what-is-the-role-of-medications-in-the-treatment-of-erythroleukemia

... and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. ... describe how you can be exposed to these agents, ... aware of the adverse health effects of antineoplastic agents, ... The purpose of this brochure is to make you aware of the adverse health effects of antineoplastic agents, describe how you can ... and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. ...

https://www.cdc.gov/niosh/docs/2004-102/default.html

It may be given as a single agent or as part of a multidrug treatment regimen; depending on protocol of choice, the dose and ... Chemotherapy is typically ineffective in γ-heavy chain disease (HCD). Agents that are effective in lymphoma and multiple ... Chlorambucil is a nitrogen-mustard alkylating agent, generally used for the treatment of chronic lymphocytic leukemia, ... Vincristine is a vesicant agent that blocks mitosis by arresting cells in metaphase. ...

https://emedicine.medscape.com/article/200675-medication

... be applied to both air and surface monitoring samples to provide a broader indication of risk to combinations of these agents. ... Simultaneous analysis of common antineoplastic agents potentially hazardous to healthcare workers is of much interest for the ... Drugs; Antineoplastic-agents; Hazardous-materials; Health-care-facilities; Health-care-personnel; Health-hazards; Occupational- ... Simultaneous analysis of common antineoplastic agents potentially hazardous to healthcare workers is of much interest for the ...

https://www.cdc.gov/niosh/nioshtic-2/20037544.html

EP-1465876-B1 chemical patent summary.

https://pubchem.ncbi.nlm.nih.gov/patent/EP-1465876-B1

Antineoplastics, Anti-CD20 Monoclonal Antibodies. Rituximab (Rituxan). *View full drug information. Rituximab is an anti-CD20 ... Antimycobacterial Agents. Class Summary. Therapy must be comprehensive and should cover all likely pathogens in the context of ... These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the ...

https://emedicine.medscape.com/article/1065402-medication

You searched for: Subject antineoplastic agents Remove constraint Subject: antineoplastic agents Subject term antineoplastic ... aldehydes; anti-infective agents; antibacterial properties; antineoplastic activity; antineoplastic agents; apoptosis; breast ... antineoplastic activity; antineoplastic agents; organic chemistry. Abstract:. ... The pyrimidine scaffold represents one of the ... X-radiation; antineoplastic activity; antineoplastic agents; drug therapy; radiolysis; radiotherapy. Abstract:. ... Precisely ...

https://pubag.nal.usda.gov/?f%5Bsubject_facet%5D%5B%5D=antineoplastic+agents&f%5Bsubject_term%5D%5B%5D=antineoplastic+activity&f%5Btext_availability_facet%5D%5B%5D=Citation+in+PubAg&per_page=50&sort=relevance

Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. George Pettit, Matthew P. ... Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate. Journal of Medicinal ... Antineoplastic agents. 465. Structural modification of resveratrol : Sodium resverastatin phosphate. In: Journal of Medicinal ... Pettit, G., Grealish, M. P., Jung, M. K., Hamel, E., Pettit, R., Chapuis, J., & Schmidt, J. M. (2002). Antineoplastic agents. ...

https://asu.pure.elsevier.com/en/publications/antineoplastic-agents-465-structural-modification-of-resveratrol-

Antineoplastic Agents for Medicine faster and easier with Picmonics unforgettable videos, stories, and quizzes! Picmonic is ... Alkylating Agent. Cross-links DNA. Crosses Blood-Brain Barrier. Indications. Glioblastoma. Side Effects. Myelosuppression. ...

https://www.picmonic.com/pathways/medicine/books/pharmacology-12006/43660?scroll_to=content

These agents cause DNA damage and disrupt DNA replication. Most chemotherapy is given in the inpatient setting. Standard of ... Lomustine (CCNU), a nitrogen mustard and DNA alkylator used in combination with other chemotherapeutic agents. Acts by ... Cisplatin, a heavy metal platinum derivative used in combination with other chemotherapeutic agents. It exerts its cytotoxic ... Vincristine, a plant-derived vinca alkaloid used during radiotherapy and in combination with other chemotherapeutic agents. ...

https://emedicine.staging.medscape.com/article/987886-medication

Antineoplastic Agents. Class Summary. Although surgery is the first line of treatment, everolimus may be considered for ...

https://www.staging.medscape.com/answers/426400-117925/what-is-the-role-of-medications-in-the-treatment-of-carcinoid-lung-tumors

Monoclonal antibody given with anti-neoplastic intent.. * Subject has received any of the following within 14 days prior to the ... Investigational therapy, including targeted small molecule agents.. * Subject has received the following within 7 days prior to ...

https://clinicaltrials.gov/show/NCT02471391

Antineoplastic Agents / analysis* * Antineoplastic Agents / urine* * Biomarkers / urine * Cross-Sectional Studies * ... Introduction: Antineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. Healthcare professionals are ... Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross- ...

https://pubmed.ncbi.nlm.nih.gov/31712349/

ATC code L: Antineoplastic and immunomodulating agents is a section of the Anatomical Therapeutic Chemical Classification ...

http://profarma.al/index.php/profarma-products/profarma-product-categories/atc/antineoplastic-and-immunomodulating-agents

Antineoplastic Agent, BodyBuilding, Estrogen Receptor Antagonist, Selective Estrogen Receptor Modulator. Cytotam (Nolvadex)20 ... Antineoplastic Agent, BodyBuilding, Estrogen Receptor Antagonist, Selective Estrogen Receptor Modulator. Cytotam (Nolvadex)10 ... Acne, Acne Products, Antineoplastic Agent, Retinoic Acid Derivatives, Vitamin A Derivative. Tretiva (Accutane)20 Mg - 10 tablet ... Acne, Acne Products, Antineoplastic Agent, Retinoic Acid Derivatives, Vitamin A Derivative. Tretiva (Accutane)10 Mg - 10 tablet ...

https://genericonlinemedicine.com/product-category/antineoplastic-agent/

Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating ... Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the ... agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in ...

https://pharmacycode.com/Leukeran.html

Minimal-change disease (MCD), also known as lipoid nephrosis or nil disease, is the most common single form of nephrotic syndrome in children. It refers to a histopathologic lesion in the glomerulus that almost always is associated with nephrotic syndrome.

https://www.staging.medscape.com/answers/243348-170075/which-medications-in-the-drug-class-corticosteroids-are-used-in-the-treatment-of-minimal-change-disease

Antineoplastic agents -- toxicity , Immunosuppressive agents -- toxicityNLM classification: QZ 202 Tags from this library: No ... Some antineoplastic and immunosuppressive agents / this publication represents the views and expert opinions of an IARC Working ... some Antineoplastic and Immunosuppressive Agents (1980: Lyon, France)Contributor(s): International Agency for Research on ...

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See Drug Interventions by Category , Antineoplastic Agents. Please enable JavaScript to see the table of Drug Interventions ...

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Global Antineoplastic Agents Market, Analysis, Size, Share, Trends, COVID-19 Impact, and Forecast 2022 2029 By Type (Type I, ... The global Antineoplastic Agents Market report discusses different scenarios of the Antineoplastic Agents Market and offers a ... The global Antineoplastic Agents market was valued at US$ XX Billion in 2021 and is projected to reach US$ Antineoplastic ... Latin America Antineoplastic Agents Market, Overview, Size, and Forecast. 8.4.1. Brazil 8.4.2. Argentina. 8.4.3. Rest of Latin ...

https://globalmarketvision.com/reports/global-antineoplastic-agents-market/164405

Results of search for ccl=su:{Antineoplastic agents} Refine your search. *. Availability. * Limit to currently available ...

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Meltz, M. L. ; Winters, D. W. / Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. ... Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. / Meltz, M. L.; Winters, D. W. ... Meltz, ML & Winters, DW 1979, Utilization of metabolic activation for in vitro screening of potential antineoplastic agents, ... Utilization of metabolic activation for in vitro screening of potential antineoplastic agents. Cancer Treatment Reports. 1979; ...

https://scholars.uthscsa.edu/en/publications/utilization-of-metabolic-activation-for-in-vitro-screening-of-pot

Antineoplastic Agents, Phytogenic / chemistry * Antineoplastic Agents, Phytogenic / isolation & purification * Antineoplastic ... Background: The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop ... and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the ...

https://pubmed.ncbi.nlm.nih.gov/33342418/

Anti-neoplastic agents (Med Chem:- 2) Notes Download. by Mihir jesur. December 19, 2021. December 19, 2021. 0589 ... Many of these agents act on dividing and resting cells, and thus are cell cycle -non-specific. Some o f these agents show CNS ... ClassificationThe anti-neoplastic agents are classified as follows:1) Alkylating agentsNitrogen mustards Mechlorethamine ( ... Alkylating agents are chemically reactive compounds. It combines most easily with nucleophilic centres, and a fully saturated ...

https://remixeducation.in/anti-neoplastic-agents-med-chem-2-notes-download/

The US was the first to approve 59 (84.28%) out of the 70 new antineoplastic agents, the EU was the first to approve 9 (12.85 ... The present study was undertaken to assess the drug lag for new antineoplastic agents in India compared with that in the United ... Kataria Bhaven C, Mehta Dimple S, Chhaiya Sunita B. Approval of antineoplastic agents in India: comparison with the US and EU ... We assessed absolute and relative drug lag for new antineoplastic agents approved in the three regions. Results: Of the 70 new ...

https://imsear.searo.who.int/handle/123456789/153369

In a study of nurses and pharmacists with occupational exposure to antineoplastic agents, maternal exposure to antineoplastic ... Agents that interfere with the menstrual cycle and ovulation, such as hormonally active agents, may affect fertility [Windham ... Antineoplastic drugs. Miscarriage, low birth weight, birth defects. Certain ethylene glycol ethers such as 2-ethoxyethanol (2EE ... Agents that interfere with male hormones or with hormonal feedback (e.g., testosterone, luteinizing hormone [LH]) may also ...

https://www.atsdr.cdc.gov/csem/pediatric-environmental-health/preconception.html

Selective immunomodulation by the antineoplastic agent mitoxantrone. I. Suppression of B lymphocyte function.. *J. Fidler, S. ... Selective immunomodulation by the antineoplastic agent mitoxantrone. II. Nonspecific adherent suppressor cells derived from ...

https://www.semanticscholar.org/paper/Treatment-of-Marburg-Variant-Multiple-Sclerosis-Jeffery-Lefkowitz/b30346fc7a6182f4d54bf1fa832b32653d0c09fe

Quimio em casa: application for family members of children and adolescents using oral antineoplastic agents / Quimio en casa: ... specific care for each chemotherapy agent, adverse effects, when to go to the emergency room and daily checking of ... mobile application for the guidance of family members of children and adolescents undergoing treatment with oral antineoplastic ...

https://pesquisa.bvsalud.org/saudepublica/resource/pt/biblio-1377402

Cobb E. Antineoplastic agent from Cnicus benedictus. Patent Brit 1973;335:181. ... Hirano, T., Gotoh, M., and Oka, K. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 ...

https://medlineplus.gov/druginfo/natural/94.html

ATC code L: Antineoplastic and immunomodulating agents is a section of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. (profarma.al)

The COVID-19 pandemic has significantly affected the global Antineoplastic Agents market in 2020. (globalmarketvision.com)
De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. (mitophysiology.org)

Chlorambucil is a nitrogen-mustard alkylating agent, generally used for the treatment of chronic lymphocytic leukemia, Waldenstrom macroglobulinemia, and as a second- or third-line therapy for patients with lymphomas. (medscape.com)
Acts similarly to alkylating agents by crosslinking DNA and inhibiting DNA replication. (medscape.com)
Chlorambucil is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. (pharmacycode.com)
Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. (pharmacycode.com)
Alkylating agents are cell cycle-nonspecific. (pharmacycode.com)
Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. (pharmacycode.com)
Alkylating agents are chemically reactive compounds. (remixeducation.in)
from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
ed tissues, the intensity of which and chemical alkylating agents are varies with the degree of antigenic considered to cause cancer primar- Immunosuppressive difference between graft and host. (who.int)
An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)

Meltz, ML & Winters, DW 1979, ' Utilization of metabolic activation for in vitro screening of potential antineoplastic agents ', Cancer Treatment Reports , vol. 63, no. 11-12, pp. 1795-1801. (uthscsa.edu)
LY2801653 , also known as Merestinib, is a n orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. (newdrugapprovals.org)

The contents that guided the application development were storage, handling, administration , specific care for each chemotherapy agent, adverse effects , when to go to the emergency room and daily checking of administrations. (bvsalud.org)
3 Whereas hazardousdrugs include a variety ofagents?among them cancer chemotherapy,antiviral drugs, and hormones?the ASHP/OSHA definition may not accuratelyreflect the hazardous risks ofmore-recent agents. (pharmacytimes.com)
Purpose Novel antitumor therapies against the PI3K-AKT-mTOR pathway are increasingly used to treat cancer, either as single agents or in combination with chemotherapy or other targeted therapies. (icr.ac.uk)
This should be taken into consideration during the design and conduct of trials involving PI3K-AKT-mTOR pathway inhibitors, particularly when combined with chemotherapy or myelosuppressive agents. (icr.ac.uk)
As certain cytotoxic antineoplastic agents, such as anthracyclines, generate reactive oxygen species as a by-product of their mechanism of action, we examined whether redox protein expression was involved in the response to anthracycline-based chemotherapy and with clinical outcome. (nottingham.ac.uk)
Although many cancers can be treated efficiently in first line chemotherapy, relapse and refractory cancers require the discovery and development of new anti cancer agents. (univie.ac.at)

IntroductionAlkylating agents exert cytotoxic and radiomimetic actions. (remixeducation.in)

Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. (usda.gov)
The lifetime when appropriate levels of its application in anticancer chemo- Group 1 agents that act by immuno- immunosuppression are maintained. (who.int)

Vincristine, a plant-derived vinca alkaloid used during radiotherapy and in combination with other chemotherapeutic agents. (medscape.com)

Antineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. (nih.gov)
therefore, a drug lag in the availability of antineoplastic drugs is a direct threat to life. (who.int)
to develop and validate a mobile application for the guidance of family members of children and adolescents undergoing treatment with oral antineoplastic drugs . (bvsalud.org)
Hydroxyurea belongs to a group of drugs called antineoplastic agents. (rxwiki.com)
Exposure to hazardous agents canoccur during the preparation, administration,or disposal of these drugs whenhealth care workers create aerosols,generate dust, clean up spills, or touchcontaminated surfaces. (pharmacytimes.com)
Adverse effects of hazardous drugsthrough occupational exposure werefirst reported nearly 30 years ago, whenan increased incidence of genotoxicitywas documented in pharmacists andnurses handling antineoplastic drugs. (pharmacytimes.com)

The global Antineoplastic Agents Market report discusses different scenarios of the Antineoplastic Agents Market and offers a comprehensive analysis of historical data (2016-2019), providing a detailed study on emerging trends and strategic decisions businesses take to gain adequate growth in the global market. (globalmarketvision.com)

Peptide transporters display a remarkable capacity to recognise a diverse library of di‐ and tri-peptides, making them extremely promiscuous and major contributors to the pharmacokinetic profile of several important drug classes, including beta-lactam antibiotics, anti-viral and antineoplastic agents. (biorxiv.org)

validación con doce familiares de niños y adolescentes en quimioterapia oral y adaptación final de la aplicación móvil. (bvsalud.org)
se devolvió la aplicación "Quimio em Casa" con dos interfaces, una versión de escritorio dirigida a profesionales de la salud y la aplicación para familiares de niños y adolescentes en tratamiento con quimioterapia oral. (bvsalud.org)
la aplicación demostró ser válida como tecnología educativa en aplicación práctica con familiares de niños y adolescentes en quimioterapia oral. (bvsalud.org)

Ils proviennent, notamment, de la British Columbia Cancer Agency (BCCA), de l'European Society of Medical Oncology (ESMO) en collaboration avec l'European Oncology Nursing Society (EONS), du Gippsland Oncology Nurses Group (GONG), du Humber and Yorkshire Coast Cancer Network (HYCCN), de l'Oncology Nursing Society (ONS) et du West of Scotland Cancer Advisory Network Clinical Leads Group (WOSCAN). (bvsalud.org)
Drug interactions between antineoplastic and antidepressant agents analysis of patients seen at an oncology clinic at a general hospital. (bvsalud.org)

Global Market Vision offers the report on Global Antineoplastic Agents Market Analysis and Forecast 2021-2029. (globalmarketvision.com)
The global Antineoplastic Agents market was valued at US$ XX Billion in 2021 and is projected to reach US$ Antineoplastic Agents. (globalmarketvision.com)
Global Market Vision provides an analysis of the key segment and each sub-segment of the global Antineoplastic Agents market, along with forecasts at the global, regional, and country levels from 2021-2027. (globalmarketvision.com)

Some antineoplastic and immunosuppressive agents / this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, which met in Lyon, 14-21 October 1980. (who.int)

The approach used to select the five agents was to obtain a list of the agents used most frequently in both a cancer hospital and an outpatient cancer treatment center, then review the list to determine which agents were potentially more hazardous to human health. (cdc.gov)
The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop new methods for obtaining materials with more effective and safe anti-cancer properties. (nih.gov)
L'objectif est de faire état de la documentation scientifique pertinente concernant la prise en charge et le traitement de l'extravasation survenue au cours de l'administration de chimiothérapie à des patients atteints de cancer. (bvsalud.org)
The primary endpoint of the study is overall survival, and secondary endpoints include time to castration-resistant prostate cancer, time to initiation of subsequent antineoplastic therapy, symptomatic skeletal event free survival (SSE-FS), time to first symptomatic skeletal event (SSE), time to initiation of opioid use, time to pain progression, time to worsening of physical symptoms of disease and safety. (salesandmarketingnetwork.com)

P = 0.03) infection when compared with single-agent PI3K-AKT-mTOR inhibitors.Conclusions Inhibitors of the PI3K-AKT-mTOR pathway can be associated with a higher risk of infection. (icr.ac.uk)

Vincristine is a vesicant agent that blocks mitosis by arresting cells in metaphase. (medscape.com)

The purpose of this brochure is to make you aware of the adverse health effects of antineoplastic agents, describe how you can be exposed to these agents, and provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. (cdc.gov)
To overcome the obstacles of traditional physical and chemical methods for the synthesis of such nanoparticles, a new, less expensive, and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the desired metallic nanoparticles from their precursors, a process called green biosynthesis of nanoparticles. (nih.gov)
Methods: The new antineoplastic agents approved in the United States, European Union and India between 1999 and 2011 were identified and information was gathered primarily from the websites of regulatory agencies of the three regions. (who.int)
METHODS: We created an agent-based model representing the Chicago population and conducted experiments to determine the effects of varying adult out-of-household activities (OOHA), school reopening, and protective behaviors across age groups on COVID-19 transmission and hospitalizations. (bvsalud.org)

IMSEAR at SEARO: Approval of antineoplastic agents in India: comparison with the US and EU regions. (who.int)
Kataria Bhaven C, Mehta Dimple S, Chhaiya Sunita B. Approval of antineoplastic agents in India: comparison with the US and EU regions. (who.int)

Agents that interfere with male hormones or with hormonal feedback (e.g., testosterone, luteinizing hormone [LH]) may also affect production of healthy sperm, thus affecting fertility [Osorio and Windham 2004]. (cdc.gov)
Nilutamide: possible utility as a second-line hormonal agent. (uchicago.edu)

This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. (usda.gov)

Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. (scielo.br)
These agents have been shown to be beneficial in the treatment of linear IgA dermatosis. (medscape.com)
Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
Imatinib-associated lichenoid eruption: acitretin treatment allows maintained antineoplastic effect. (web.app)
The treatment options include no treatment and treatment with a low- to mid-potency topical corticosteroid (alone or in combination with a keratolytic agent). (web.app)
In the United States topical aminolevulinic acid (ALA) is approved as a photosensitizing agent for this treatment, and it has traditionally been activated with the use of an in-office artificial light source. (trialbulletin.com)

Lomustine (CCNU), a nitrogen mustard and DNA alkylator used in combination with other chemotherapeutic agents. (medscape.com)
Cisplatin, a heavy metal platinum derivative used in combination with other chemotherapeutic agents. (medscape.com)

L'utilisation du diméthylsulfoxide (DMSO), de la dexrazoxane, de l'hyaluronidase ou du thiosulfate de sodium est recommandée selon l'agent en cause de l'extravasation. (bvsalud.org)

These agents are used to improve the clinical and immunologic aspects of the disease. (medscape.com)

The present study was undertaken to assess the drug lag for new antineoplastic agents in India compared with that in the United States (US) or European Union (EU). (who.int)

It was determined that the ability to simultaneously evaluate five frequently used, potentially hazardous agents was sufficient for general evaluation of exposures to healthcare workers. (cdc.gov)

Agents that are effective in lymphoma and multiple myeloma have generally been used, but results have been disappointing. (medscape.com)

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)

Anatomy6

Organisms5

Diseases15

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes24

Disciplines and Occupations1

Technology, Industry, Agriculture4

Named Groups5

Health Care17

Electronic volume analysis of L1210 chemotherapy. (1/35913)

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (2/35913)

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (3/35913)

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (4/35913)

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (5/35913)

Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. (6/35913)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (7/35913)

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (8/35913)

Antineoplastic Agents

Antineoplastic Agents, Phytogenic

Leukemia P388

Amaryllidaceae Alkaloids

Narcissus

Ellipticines

Bibenzyls

Doxorubicin

Drug Screening Assays, Antitumor

Antibiotics, Antineoplastic

Thiadiazines

Bryostatins

Antineoplastic Agents, Alkylating

Ancitabine

Neoplasms

Gallium

Depsipeptides

Tumor Cells, Cultured

Cisplatin

Paclitaxel

6-Mercaptopurine

Drug Synergism

Apoptosis

Aminoacridines

Epothilones

Cell Line, Tumor

Cell Survival

Sarcoma 180

Molecular Structure

Lactones

Leukemia L1210

Antimetabolites, Antineoplastic

Daunorubicin

Fluorouracil

Bleomycin

Dose-Response Relationship, Drug

Etoposide

Antineoplastic Combined Chemotherapy Protocols

Drug Resistance, Neoplasm

Prodrugs

Drug Evaluation, Preclinical

Drug Evaluation

Cell Division

Xenograft Model Antitumor Assays

Drug Resistance

Macrolides

Neoplasms, Experimental

Methotrexate

Camptothecin

Stilbenes

Cell Cycle

Mice, Nude

HL-60 Cells

Enzyme Inhibitors

Cell Proliferation

Lung Neoplasms

Drug Administration Schedule

Vincristine

Isoquinolines

Neoplasm Transplantation

Biotransformation

Drug Interactions

Breast Neoplasms

DNA Damage

Cyclophosphamide

Stereoisomerism

Time Factors

Clinical Trials as Topic

Leukemia

Cell Line

Kinetics

Ovarian Neoplasms

Colonic Neoplasms

Caspases

Taxoids

Prostatic Neoplasms

Structure-Activity Relationship

DNA

Phospholipid Ethers

RNA, Messenger