Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.Antinematodal Agents: Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)Trichuriasis: Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.Trichuris: A genus of nematode worms comprising the whipworms.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)Cerebellar Neoplasms: Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)Brain Stem Neoplasms: Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.Hookworm Infections: Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.United StatesPeer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.AcetophenonesPhosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.PhosphoproteinsBenzopyrans: Compounds with a core of fused benzo-pyran rings.Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.Protein Kinase C-delta: A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.Eukaryotic Initiation Factor-4E: A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.AmidinesTrientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.Science: The study of natural phenomena by observation, measurement, and experimentation.trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride: An anticholesteremic agent that inhibits sterol biosynthesis in animals.Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.Dilazep: Coronary vasodilator with some antiarrhythmic activity.Trimetazidine: A vasodilator used in angina of effort or ischemic heart disease.Methylhydrazines: Hydrazines substituted by one or more methyl groups in any position.Dianisidine: Highly toxic compound which can cause skin irritation and sensitization. It is used in manufacture of azo dyes.Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.

Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (1/284)

AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug.  (+info)

Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979. (2/284)

Beauveria sp. FO-6979, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. A new compound beauveriolide III was isolated along with a known compound beauveriolide I from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography, silica gel column chromatography and preparative HPLC. Beauveriolides I and III caused a reduction in the number and size of cytosolic lipid droplets in macrophages at 10 microM without any cytotoxic effect on macrophages.  (+info)

Resistance to levamisole resolved at the single-channel level. (3/284)

Levamisole is commonly used to treat nematode parasite infections but therapy is limited by resistance. The purpose of this study was to determine the mechanism of resistance to this selective nicotinic drug. Levamisole receptor channel currents in muscle patches from levamisole-sensitive and levamisole-resistant isolates of the parasitic nematode Oesophagostomum dentatum were compared. The number of channels present in patches of sensitive and resistant isolates was similar at 10 microM levamisole, but at 30 microM and 100 microM the resistant isolate contained fewer active patches, suggesting desensitization. Mean Po and open times were reduced in resistant isolates. The distribution of conductances of channels in the sensitive isolate revealed a heterogeneous receptor population and the presence of G25, G35, G40, and G45 subtypes. A G35 subtype was missing in the resistant isolate. Resistance to levamisole was produced by changes in the averaged properties of the levamisole receptor population, with some receptors from sensitive and resistant isolates having indistinguishable characteristics.  (+info)

Maintaining compliance to ivermectin in communities in two West African countries. (4/284)

We have investigated various aspects related to managing wide-scale ivermectin distribution schemes within randomized controlled trials in communities where onchocerciasis is endemic. Multiple logistic regression analysis of determinants of compliance to five doses of ivermectin in 589 people in Sierra Leone showed independent significant associations with leopard skin depigmentation, the severity of side effects of treatment, fulfilling the exclusion criteria for treatment, and long-term residence in the community. These results are useful for tailoring health promotion messages in Sierra Leone, but the associations may differ in other West African societies. In Nigeria 1847 people were interviewed about various subjective responses, including itching. None of these showed clear improvement after three years of ivermectin treatment. Positive comments about treatment were generally non-specific and similar in the placebo and ivermectin groups. Negative comments were usually related to adverse reactions, especially itching and rash, and were more common after ivermectin. The lack of any benefit attributable to ivermectin that is discernible to its recipients may make it difficult to maintain the high compliance rates needed for long periods if mass dosing programmes are to have a lasting impact on onchocerciasis. In addition, no consistent effects of ivermectin were found by measuring visual acuity, height, weight or haematocrit in comparison with placebo. This may indicate that evidence of clinical impact is very slow to develop and is hard to measure using simple objective methods after only three doses of treatment. At present it seems that parasitological, entomological and detailed ophthalmological or dermatological methods are required to demonstrate the impact of ivermectin treatment in the medium-term.  (+info)

Case studies in international medicine. (5/284)

Family physicians in the United States are increasingly called on to manage the complex clinical problems of newly arrived immigrants and refugees. Case studies and discussions are provided in this article to update physicians on the diagnosis and management of potentially unfamiliar ailments, including strongyloidiasis, hookworm infection, cysticercosis, clonorchiasis and tropical pancreatitis. Albendazole and ivermectin, two important drugs in the treatment of some worm infections, are now available in the United States.  (+info)

A controlled evaluation of two school-based anthelminthic chemotherapy regimens on intensity of intestinal helminth infections. (6/284)

BACKGROUND: School-based deworming programmes have been promoted as a cost-effective strategy for control of nematode infection in developing countries. While numerous efficacy studies have been conducted, there is little information on actual programme effectiveness in areas of intense transmission. METHODS: A randomized trial of a school-based deworming programme was conducted in 12 primary schools on Pemba Island, Zanzibar. Four schools each were randomized to control, twice a year deworming with single dose mebendazole or three times a year deworming. Baseline and 12-month follow-up data on helminth infection using the Kato-Katz technique, demographic information and nutritional status were collected on 3028 children from March 1994 to May 1995. RESULTS: Intensity of infection measured as eggs per gram of faeces (epg) declined significantly for Ascaris lumbricoides, Trichuris trichiura and hookworm infections in both treatment groups. A. lumbricoides infection intensity declined 63.1% and 96.7% in the twice and three times per year treatment groups compared to the controls. T. trichiura infection intensity declined 40.4% and 75.9% respectively and hookworm intensity declined 35.3% and 57.2% respectively compared to control schools. CONCLUSIONS: These results suggest that school-based programmes can be a cost-effective approach for controlling the intensity of intestinal helminth infection even in environments where transmission is high.  (+info)

Liver tumor promoting effects of fenbendazole in rats. (7/284)

In order to examine whether fenbendazole has tumor-promoting activity, a total of 70 male Fischer 344 rats were initiated with a single intraperitoneal injection of 100 mg/kg of diethylnitrosamine (DEN) or were given the saline vehicle alone; beginning 1 wk later, rats were given a diet containing 3,600; 1,800; 600; 200; 70; or 0 ppm of fenbendazole for 8 wk. Subgroups of 5 rats each from the DEN+ 1,800; DEN+0; 1,800; and 0 ppm groups were euthanatized after 1 wk of fenbendazole treatment, and the remaining animals were euthanatized at 8 wk. After 1 wk, relative liver weights (ratios to body weights) were significantly increased in the DEN+ 1,800 and 1,800 ppm groups, and based on light microscopy, periportal hepatocellular hypertrophy was evident in these groups. After 8 wk, relative liver weights were significantly increased in the groups given > or =600 ppm with or without DEN initiation. Periportal hepatocellular hypertrophy, characterized by a marked increase in smooth endoplasmic reticulum, was observed in the groups given > or =600 ppm with or without DEN initiation. Induction of cytochrome P-450 (CYP) 1A2, 2B1, or 4A1 was noted in the fenbendazole-treated groups with or without DEN initiation; that associated with CYP 1A2 was most marked. Positive immunostaining for anti-CYP 1A1/2 or CYP 2B1/2 was observed diffusely in the livers of animals in the DEN+1,800 and DEN+3,600 ppm groups. The numbers and areas of connexin 32 (Cx32)-positive spots per square centimeter in centrilobular hepatocytes were significantly decreased in an almost dose-dependent manner with fenbendazole treatment after DEN initiation. In situ hybridization for Cx32 mRNA revealed a remarkable decrease in its expression in the centrilobular hepatocytes in the DEN+70 ppm group. The numbers of glutathione S-transferase placental-form positive single cells (plus mini foci) were significantly increased in the DEN+ 1,800 and DEN+3,600 ppm groups. Since those agents that induce CYP 2B1/2 isozymes and reduce Cx32 in centrilobular hepatocytes have been suggested to be liver tumor promoters, the present results indicate that fenbendazole may be a liver tumor promoter.  (+info)

Structures of flagranones A, B and C, cyclohexenoxide antibiotics from the nematode-trapping fungus Duddingtonia flagrans. (8/284)

Spectroscopic data define the structures of the flagranones A (2), B (3) and C (4) from the nematode-trapping fungus Duddingtonia flagrans. These antibiotics are structurally related to the farnesylated cyclohexenoxides of the oligosporon group recently isolated from the nematode-trapping fungus Arthrobotrys oligospora, and show similar antimicrobial activity.  (+info)

*Antinematodal agent

An antinematodal agent is a type of anthelmintic designed to reduce nematode infection. Antinematodal agent at the US National ...

*Nematode infection

Several antinematodal agents are available.. ...

*Penicillium cluniae

... is a fungus species of the genus of Penicillium which produces the antinematodal and antiparasitic agents ... Liesch, J. M.; Wichmann, C. F. (1990). "Novel antinematodal and antiparasitic agents from Penicillium charlesii. II. Structure ...

*List of MeSH codes (D16)

... antiparasitic agents MeSH D27.505.954.122.250.075 --- anthelmintics MeSH D27.505.954.122.250.075.080 --- antinematodal agents ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...
cochlioquinone A: from Helminthosporium sativum; competitive inhibitor of ivermectin binding; RN from Chem Abstract Index Guide 1990; structure given in first source
This medication is best taken after meals with a full glass of water, fruit juice, or tea, unless your doctor instructs otherwise. Tablets may be crushed and mixed with chocolate syrup, honey, or jam for persons who cannot stand the bitter taste or have difficulty swallowing tablets. If you miss a dose, take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose. Take it as prescribed for the full treatment period, even if you feel better before the scheduled end of therapy ...
This medication is best taken after meals with a full glass of water, fruit juice, or tea, unless your doctor instructs otherwise. Tablets may be crushed and mixed with chocolate syrup, honey, or jam for persons who cannot stand the bitter taste or have difficulty swallowing tablets. If you miss a dose, take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose. Take it as prescribed for the full treatment period, even if you feel better before the scheduled end of therapy ...
IDENTIFICATION OF PROTEINS WITH NEMATICIDAL ACTIVITY USING AN AXENIC CHEMICALLY-DEFINED NUTRIENT MEDIA ASSAY.. Hocker, James Randolph and Karel Schubert.. Department of Botany-Microbiology, University of Oklahoma, 770 Van Vleet Oval, Norman, OK 73069-9984.. This Poster was presented at the Society of Nematologists meeting in St.Louis, MO on June 22, 1998.. Abstract. An assay was developed to identify proteins with biological activity capable of reducing nematode reproduction. An axenic chemically-defined culture media was used to test several isolated protein fractions from seeds of a tropical legume. The nematode Caenorhabditis elegans was cultured at 20 C in 2.5 ml replicated stationary cultures. Populations were observed and recorded every 3 to 4 days over a period of 2-3 weeks. Controls and non-active fractions contained comparable populations. An active fraction was identified after separation by gel-filtration chromatography. Maximum nematode populations containing the active fractions ...
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This chapter is an update of the chapter which appeared in The Mycota, Vol. Xin 2002. Not many novel compounds with nematicidal and insecticidal activities have been described in the meantime....
This study aimed to elucidate the therapeutic effects of oral administration of intracellular melanin from Lachnum YM156 (LIM) on chronic renal failure (CRF) in mice. The cytotoxicity of LIM was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. CRF was induced in m
MIXOTROPHIC CHLORELLA-BASED COMPOSITION, AND METHODS OF ITS PREPARATION AND APPLICATION TO PLANTS | ANTI-ADHERENT BOTANICAL COMPOSITIONS | INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE | BACTERIA WITH NEMATICIDAL ACTIVITY AND THE ABILITY TO PROMOTE PLANT GROWTH | MICROBIAL COMPOSITIONS AND METHODS OF USE FOR BENEFITING PLANT GROWTH AND TREATING PLANT DISEASE |
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Ron Smith Josielle Rezende, LSU AgCenter research associate, discussed the guava root knot nematode at the recent Louisiana Agricultural Technology and Management Conference in Marksville, La. Guava root knot nematode, worlds most aggressive Guava root knot nematode reported to be more difficult to manage than the southern root knot nematode. Ron Smith | Mar 12,…
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Widespread concern for the occurrence of resistant strains, along with the avoidance of the use of highly toxic insecticides and their wide environmental dispersal, highlights the need for the development of new and safer pest control agents. Natural products provide inspiration for new chemical entities with biological activities, and their analogues are good lead compounds for the development of new pest control agents. For this purpose, we evaluated the larvicidal and nematicidal activities of 48 3-acylbarbituric acid analogues against the Asian tiger mosquito, Aedes albopictus and the pine wood nematode, Bursaphelenchus xylophilus, organisms of increasing global concern. Among the 48 3-acylbarbituric acid analogues, four compounds-10, 14d, 14g and 19b-showed |90% larvicidal activity against Ae. albopictus at 10 μg/mL concentration, and one (compound 10) showed the strongest larvicidal activity against Ae. albopictus, with a LC50 value of 0.22 μg/mL. Only compound 18 showed strong nematicidal
In this study, we investigated global changes in miRNAs of Meloidogyne incognita throughout its life cycle. Small RNA sequencing resulted in approximately 62, 38, 38, 35, and 39 Mb reads in the egg, J2, J3, J4, and female stages, respectively. Overall, we identified 2724 known and 383 novel miRNAs (read count > 10) from all stages, of which 169 known and 13 novel miRNA were common to all the five stages. Among the stage-specific miRNAs, miR-286 was highly expressed in eggs, miR-2401 in J2, miR-8 and miR-187 in J3, miR-6736 in J4, and miR-17 in the female stages. These miRNAs are reported to be involved in embryo and neural development, muscular function, and control of apoptosis. Cluster analysis indicated the presence of 91 miRNA clusters, of which 36 clusters were novel and identified in this study. Comparison of miRNA families with other nematodes showed 17 families to be commonly absent in animal parasitic nematodes and M. incognita. Validation of 43 predicted common and stage-specific miRNA by
Two root-knot nematode species, Me/oidogyne incognita and M.javanica, were studied with regard to their seasonal population fluctuations on grapevines growing in two vastly different climatic areas. Regular observations on reproduction and numbers of larvae in the soil were compared with patterns of root growth, soil temperature and moisture. Population fluctuations of the two species showed similar trends in spite of the climatic differences in the two areas, but M. incognita in the northern Cape reached higher populations. Larvae populations in the soil declined in summer in both areas and increased during autumn to reach peaks in winter. With the onset of root growth in spring, larvae numbers decreased in the soil, as a result of large scale root penetration.. ...
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Antiox(Mebendazole): Treatment of single or mixed GI worm infestations by roundworm, whipworm, hookworm, pinworm, Regulatory Classification. Non-Rx. Consumer information about the medication mebendazole (Vermox), a drug used to treat pinworms, roundworms, hookworms, whipworms, and many others.. Generic Name:Mebendazole Brand Name:Vermox Classifications: antiinfective; anthelmintic Pregnancy Category: C Availability 100 mg. Mebendazole (MBZ) is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm disease, hookworm infections. Mebendazole official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Easy to read patient leaflet for mebendazole. Includes indications, proper use, special instructions, precautions, and possible side effects. ...
The primary objectives of this study are to determine the maximum tolerated dose (MTD) of oral mebendazole in patients with recurrent/progressive pediatric brain tumors and to confirm the tolerance of the MTD of oral mebendazole by assessing tolerance in a dose expansion cohort. Secondary Objectives of the study include to determine the safety, tolerability and toxicity of mebendazole in this patient population, determine the plasma levels of mebendazole in this patient population and Determine progression-free and overall survival of mebendazole in an extended cohort of patients with treatment refractory pediatric brain cancer.. Mebendazole (MBZ) is a drug developed to treat human helminthic disease and is FDA-approved for the treatment of roundworm, common hookworm, American hookworm, pinworm and whipworm. MBZ use is well documented and frequently used in tropical countries at higher doses for the rarer parasitic infections of the brain.. We have shown efficacy in preclinical laboratory models ...
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FENBENDAZOLE POWDER - 99% PURE - The only source for pure fenbendazole. Other brands are only 22% active. Fenbendazole is used as a worming agent in tropical fish. It is extremely effective in both fresh and salt water environments against most all types of worms, including: Tapeworms, Roundworms, Hookworms, Calamus,
Plant parasitic nematodes (PPNs) place a heavy burden on agriculture throughout the world. This burden is accentuated by a lack of effective and safe methods for the control of these crop pests, with many nematicides having been banned due to unacceptable non-target toxicity. Few alternatives have emerged to fill this gap. Fluensulfone is a newly registered nematicide that has a favourable toxicity profile relative to previously used nematicides. Fluensulfone has proven efficacy in the field against a range of nematode species. The mode of action of fluensulfone is however currently unknown. The aim of this thesis was to investigate the effects of fluensulfone on nematodes and to gain insight into its mechanism of action. Caenorhabditis elegans is a model organism with well characterised genetics, neurophysiology and behaviour. C. elegans has proven useful in previous mechanism of action studies on anthelmintics. Fluensulfone was found to have nematicidal activity against C. elegans but at ...
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2) Initial. Each employer who has a place of employment in which DBCP is present, shall monitor each workplace and work operation to accurately determine the concentration of airborne DBCP to which employees may be exposed. Such monitoring shall be conducted as soon as possible but not latter than 30 days following the effective date of this section. Each employer who has a place of employment in which DBCP is present, shall monitor each workplace and work operation to accurately determine the concentration of airborne DBCP to which employees may be exposed. Such monitoring shall be conducted as soon as possible but not latter than 30 days following the effective date of this section ...
Fig. 1. Annual crop yield loss in US dollars (billion) by nematodes in 2001 based on 1987 international yield loss survey (Sasser & Freckman, 1987). Ten major crops include rice, maize, potato, wheat, tomato, grape, sugarcane, yam, soybean, banana. Figure adapted and modified from McCarter, 2009. The root-knot nematodes (RKN), Meloidogyne species, are sedentary endoparasitic species which are economically the most important and wide spread throughout the world with a broad host range. Meloidogyne chitwoodi was the first species described from the Pacific Northwest of the USA in 1980 (Golden et al., 1980) which caused severe damage to potato tubers. Meloidogyne species such as Meloidogyne incognita and Meloidogyne javanica have been found at destructive levels in almost all maize growing regions of the world. Meloidogyne africana and Meloidogyne arenaria have been also found infecting maize in India and in Pakistan(McDonald & Nicol, 2005). The symptoms of root knot nematode infection ranged from ...
Selectively deuterated and methylated analogs of the nematocide 1,2-dibromo-3-chloropropane (DBCP) were compared to DBCP in causing acute renal damage in rats. All of the six deuterated analogs tested at 340 mumol/kg, including the perdeutero compound, failed to significantly alter the kidney necrosis observed at 48 hr compared to DBCP. Furthermore, when the perdeutero analog was administered at several doses (42.5, 85, 170, and 340 mumol/kg), it caused kidney damage that was not significantly different than that caused by an equivalent molar dose of nondeuterated DBCP. Of the five methylated analogs tested at 170 and 340 mumol/kg, only C3-methyl-DBCP and 1,2-dibromo-4-chlorobutane caused nephrotoxicity. The C2-methyl-, C1-dimethyl-, and C2-methyl-DBCP analogs failed to cause renal necrosis determined 48 hr after dosing. In distribution studies DBCP, perdeutero-DBCP, and all the methylated analogs were found to concentrate in the kidney approximately 25 times relative to plasma 1 hr after administration
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At the end of the incubation period order mebendazole online hiv infection using condom, pellets from each pin were transferred to 1 ml of sterile deionised water containing 0 discount 100mg mebendazole with visa antiviral eye drops. In experiment 3 order mebendazole in united states online hiv infection using condom, the ability of the fungal pellets to form a sporulating mycelial mat in the continuous presence of the adjuvants was assessed through two ways of pellet treat- ment. In the rst method, 5 ml of the biomass was transferred along with the spent medium to 15-ml glass vials and each adjuvant was added separately, swirled and incubated for 30 days by which time a sporulating mycelial mat (ca. In the second method, the adjuvant solutions were prepared separately, and the pellets obtained from 10 ml of shake-ask culture of H. In both methods, at the end of the incubation period, the 20-mm-diameter mycelial mat was transferred to 10 ml of 0. Growth and conidiation of mycelial pellets on ...
Doctors give unbiased, trusted information on whether Mebendazole can cause or treat Breastfeeding: Dr. Park on is it safe to take mebendazole while pregnant or breastfeeding: Mebendazole is used to treat intestinal parasites such as pinworms, roundworms, hookworms, and whipworms. It can be used, if needed, during pregnancy - and has not been shown to cause harm to a human fetus. However, there are no studies in pregnant humans to determine the precise risks. It is recommended to discontinue breastfeeding while taking this medication to avoid exposure for your baby.
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Wang, Yei-Zeng. A new species and a new record of Lachnum from Taiwan. Mycotaxon 87: 137 - 140. 2003.. ABSTRACT: A new species and a new record of Lachnum are described and illustrated from Taiwan. The new species, Lachnum meifengense, is characterized by its foliicolous habitat, white apothecia, fusiform ascospores, and lanceolate paraphyses. A newly recorded species, Lachnum patenum, is recognized by its white apothecia and long fusiform ascospores. KEYWORDS: discomycetes, Helotiales, Hyaloscyphaceae. ...
Johnathan Dalzell of Queens University Belfast in the United Kingdom will improve food crop productivity particularly for small hold subsistence farmers by reducing the losses caused by pathogenic nematode worms, which are estimated to cost around $125 billion per year globally. These pathogenic worms absorb small proteins called neuropeptides from their external environment directly into their central nervous system, which can influence their movement and sensory behavior. They will exploit this process to destroy the worms. In Phase I, they identified two neuropeptide genes in the root knot nematode (RKN) Meloidogyne incognita, which is a serious pathogen of many crop types. They also exposed infectious stage nematodes to a selection of neuropeptides and found 11 that inhibited their movement towards plant roots, and 13 that protected a crop plant from infection. Finally, they established protocols to genetically modify crops to express and secrete the neuropeptides. In Phase II, they will ...
Mebendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body. Mebendazole is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm. It is also used to treat infections caused by...
Nemadectin is a macrocyclic lactone antibiotic with a broad-spectrum endectocidal and nematocidal activity [1]. In dogs, oral administration of 0.2-0.4 mg/kg nemadectin (a liquid formulation administered in gelatin capsules) was effective in eliminating
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The active ingredient in Vermox is Mebendazole and its labeled as an antihelmintic kind of medication. Its used for the purpose of treating whipworm, pinworm, hookworm, roundworm, as well as other worm infections. When taken properly its able to stop worms from absorbng different sugars that they need in order to survive. What this does is it diminishes their energy source and causes them to die out within a few days. The dead worms are them eliminated from the body through stools.. What are some of the minor side effects for Vermox?. There are some minor side effects that could occur, with the main one being headaches or nausea. If you experience minor side effects, continue to take the medication and speak with a medical professional if you start experiencing something more serious such as abdominal pain, diarrhea or fever.. What are some of the more serious side effects? Allergic reactions (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or ...
quote][i]Originally posted by Dr. Jerry Vanek[/i] [br]In addition to the above new posts, heres as good a place as any to reiterate some dosages on fenbendazole and the life cycle of whipworms. I am responding to two personal e-mails which I think might benefit all. First, the dosage for fenbendazole (Panacur) is still 50 milligrams for every kilogram of dog weight. At 2.2 lb/KG that translates into 22.7 milligrams per pound of dog weight. A 22.2% concentration of fenbendazole in its Panacur carrier means there are 222 mg of drug in every gram of Panacur. So a 50-pound (22.7 KG) dog would need about 1136 mg of fenbendazole. Divided by 222 mg means the dog should get 5 grams of Panacur, which is the recommended dose on the package, which often comes in 5-gram sizes. Give a 50-pound dog the whole 5-gram packet. Every day for three days. Yum! Giving a dog that size a half-teaspoon is underdosing the dog by a third and giving the tougher worms a selective advantage. However, you cant just treat ...
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Weaned puppies and kittens under six months of age and lungworm in cats: A single dose for three consecutive days at a dose rate of 50mg/kg which is equivalent to 1ml per 2kg bodyweight.. Puppies should be treated at 2 weeks of age, 5 weeks of age and again before leaving the breeders premises. Treatment may also be required at 8 weeks and 12 weeks of age.. Thereafter, frequency of treatment can be reduced unless the pups remain in kennels where reinfestation occurs more readily.. Pregnant bitches: 1ml per 4kg bodyweight daily from day 40 of pregnancy continuously for approximately 25 days. This is equivalent to 25mg Fenbendazole/kg bodyweight daily.. Regular treatment is advisable to prevent infection of children by the larvae of ascarids of dogs and cats.. ...
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An oxfendazole worming paste used to remove pin worms from rabbits. A small amount (pea size) is given orally once.|br||br|While the comments and information are intended to be accurate and educational, no specific recommendation is made concerning the us
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TY - JOUR. T1 - Dose-related immunologic effects of levamisole in patients with cancer. AU - Janik, John Edward. AU - Kopp, W. C.. AU - Smith, J. W.. AU - Longo, D. L.. AU - Alvord, W. G.. AU - Sharfman, W. H.. AU - Fenton, R. G.. AU - Sznol, M.. AU - Steis, R. G.. AU - Creekmore, S. P.. AU - Ewel, C. H.. AU - Hursey, J.. AU - Urba, W. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Purpose: This phase I study was conducted to determine the maximum- tolerated dose (MTD) and the immunologic properties of levamisole in cancer patients when administered alone and in combination with interferon gamma (IFN-γ). Patients and Methods: Twenty patients with advanced cancer and 36 patients with completely resected melanoma (n = 33) or renal cell cancer (n = 3) received levamisole orally every other day for six doses at 1.0, 2.5, 5.0, or 10.0 mg/kg. Ten days later, patients restarted levamisole and began IFN- γ 0.1 mg/m2 by subcutaneous injection every other day. Blood samples were collected for measurement of ...
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Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
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The standard dose is 125mg of product(5mg as Fenbendazole) per kg body weight. Administer the standard dose as followings.. 1. Short term medication(individual medication): mix the standard dose into standard daily intakin feed and administer.. 2. Long term medication(herd medication) : mix the standard dose into 3~12days intaking quantity of feed and administer. ...
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Commercial essential oils from 29 plant species were tested for their nematicidal activity against the pine wood nematode, Bursaphelenchus xylophilus. Good nematicidal activity against B. xylophilus was achieved with essential oils of Gaultheria fragrantissima and Zanthoxylum alatum. GC-MS analysis of the corresponding oils led to the identification of two and ten major compounds, respectively. Four compounds, methyl salicylate, ethyl salicylate, methyl trans-cinnamate and ethyl trans-cinnamate, were tested individually for their nematicidal activities against the pine wood nematode. Methyl and ethyl salicylates showed strong nematicidal activity at concentration of 2.0 mg ml-1. Concentrations of 1.0 mg ml-1, as well as lower concentrations showed only minor effects. Another compound, methyl trans-cinnamate, showed 100% activity at concentrations of 0.0625-2.0 mg ml-1. With ethyl trans-cinnamate, 100% mortality was observed at concentrations of 0.25-2.0 mg ml-1. The essential oils and their components
Nodulation is an ecologically and economically important plant phenomenon, in which the symbiosis between plants from the family Fabaceae and the bacterial genera rhizobia results in the development of nitrogen fixing nodules on host plant roots. The rhizobia-plant interaction is initiated by Nod factors, which are produced by species-specific rhizobia; Nod factor alone is necessary and sufficient to produce many of the initial responses including ionic fluxes, root hair deformation, changes in gene expression, cortical cell differentiation and generation of a pseudo nodule. Giant cell formation by plant pathogenic root knot nematodes (RKN) invokes host genes necessary for nitrogen-nodule formation. Specific transcription regulators, cytokinin response pathways and early nodulation genes are induced in the nematode feeding site and rhizobia induced nodules. This suggests that nodulation by rhizobia and RKN infection may share host signal transduction and/or developmental pathways. The presence ...
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Resistance to root-knot nematodes [ Meloidogyne arenaria (Neal) Chitwood] is needed for cultivation of peanut in major peanut-growing areas, but significant resistance is lacking in the cultivated spe
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Accessions of Gossypium spp., some of them never previously tested, were evaluated for resistance to a local isolate of Meloidogyne incognita race 3 in greenhouse experiments. Nematode infection was characterized based on the galling and egg mass indexes and the reproduction factors (RF). Root-knot nematode reproduction among the newly tested accessions varied from highly susceptible (AS0188, AS0189) to moderately resistant (MT123 no. 3), and some accessions showed highly reduced nematode reproduction (CIR1343, CIR1348, Fai Mui). Histological observations of two resistant accessions (G. barbadense CIR1348 and G. hirsutum TX-25, respectively) showed that resistance occurs through a two-stage mechanism in the first accession and through a single-stage mechanism in the second. Parasitism is blocked early after second-stage juvenile (J2) penetration or during its initial tissue migration (CIR1348) and the development of later-stage juveniles into female adults is suppressed at a later stage (TX-25 ...
Generic Vermox (Mebendazole) is used for treatment of certain worm infections (eg, pinworm, roundworm, whipworm, hookworm). Mebendazole is an anthelmintic agent. It works by killing sensitive worms and causing them to be expelled from the body.. Generic Vermox (Mebendazole 100mg) $ 1.04 pill - Antiparasitic @ KupTania.
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Fenbendazole, in a powder form,used as a worming agent in tropical fish. Fish Bendazole is extremely effective in both fresh and salt water environments. Can be used against the calamus worm.
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The root knot nematode prefers subtropical conditions with large biomass (Devran, 2009). They are found throughout the world and affect over 2,000 species of plants. This nematode is critical in the agricultural business since it is the cause of most concern when dealing with parasites that can affect ground for generations. It is of most concern when dealing with small grains, fruits, tubers, vegetables, and turf grasses (Riedel, N/A). Once an area of land is infected with this nematode, there is little one can do about getting rid of it. There are no real natural predators for this specific nematode and thus it can be nearly impossible to get rid of. Therefore it is important to discover an infection of nematodes early on by checking for stunted plant growth, discoloration, reduction of fruit/vegetable/tuber/leaf number or any other sign that might indicate plant malnourishement (Krueger, 2008). The root creates these galls or root knots where the nematode has infected the plant. These areas ...
wormer from Merck Animal Health1, is designed for use in the drinking water for all classes of swine, except suckling piglets. The active ingredient, fenbendazole, is well-established for treating and controlling numerous types of worms. The licensed dose regimen relies on providing 2.2 mg of fenbendazole active ingredient per kg of body weight daily for 3 consecutive days. Fenbendazole, however, can be unstable in some water supplies, raising the prospect that pigs drinking treated water will receive a lower-than-intended dose due to decay of the active ingredient. Research reported by Merck veterinarians2 at the 48th Annual Meeting of the AASV verified that the fenbendazole activity in Aquasol is immediately degraded by chlorinated drinking water. The study also reported that this decay risk, which will contribute to under-dosing the wormer, is eliminated by stabilizing the chlorinated water with Vac-Pac® or Vac-Pac Plus®,3 two potent water stabilizers commonly used to improve water quality ...
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Pine wilt disease (PWD) is a complex disease integrating three major agents: the pathogenic agent, the pinewood nematode Bursaphelenchus xylophilus; the insect-vector Monochamus spp.; and the host pine tree, Pinus sp. Since the early 80s, the notion that another pathogenic agent, namely bacteria, may play a role in PWD has been gaining traction, however the role of bacteria in PWD is still unknown. The present work supports the possibility that some B. xylophilus-associated bacteria may play a significant role in the development of this disease. This is inferred as a consequence of: (i) the phenotypic characterization of a collection of 35 isolates of B. xylophilus-associated bacteria, in different tests broadly used to test plant pathogenic and plant growth promoting bacteria, and (ii) greenhouse experiments that infer the pathogenicity of these bacteria in maritime pine, Pinus pinaster. The results illustrate the presence of a heterogeneous microbial community associated with B. xylophilus and the
Abstract. The pine wood nematode, Bursaphelenchus xylophilus, is an invasive plant parasitic nematode and a worldwide quarantine pest. An indigenous species in North America and the causal agent of pine wilt disease, B. xylophilus has devastated pine production in Southeastern Asia including Japan, China, and Korea since its initial introduction in the early 1900s. The reactive oxygen species (ROS) is the first line of defense utilized by host plants against parasites, while nematodes, counteractively, employ antioxidants to facilitate their infection. Peroxiredoxins (Prxs) are a large class of antioxidants recently found in a wide variety of organisms. In this report, a gene encoding a novel 2-cysteine peroxiredoxin protein in B. xylophilus was cloned and characterized. The 2-cysteine peroxiredoxin in B. xylophilus (herein refers to as "BxPrx") is highly conserved in comparison to 2-cysteine peroxiredoxins (Prx2s) in other nematodes, which have two conserved cysteine amino acids (Cp and Cr), a ...
Two rhizosphere bacteria, Enterobacter cloacae and Pseudomonas mendocina, were isolated from the rhizosphere of tomato plants growing in a soil heavily infested with both root-knot nematodes and the parasitoid endospore-forming bacterium Pasteuria penetrans. Bacteria E. cloacae and P. mendocina stimulated plant growth, inhibited the reproduction of the root knot nematode Meloidogyne incognita, and increased the attachment of the endospores of P. penetrans on the nematodes in vitro. E. cloacae significantly increased the reproduction of P. penetrans in plant roots. Consequently, the introduction of such bacteria in soils, or cultural practices aimed to increase the activity of native strains of these bacteria, could greatly contribute to the efficiency of nematode biocontrol with P. penetrans. Stimulation de l'activite antagoniste de Pasteuria penetrans envers Meloidogyne incognita par Enterobacter cloacae et Pseudomonas mendocina - Deux bacteries rhizospheriques, Enterobacter cloacae et Pseudomonas
Before revised World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines on the detection of anthelmintic resistance can be produced, validation of modified and new methods is required in laboratories in different parts of the world. There is a great need for improved methods of detection of anthelmintic resistance particularly for the detection of macrocyclic lactone resistance and for the detection of resistant nematodes in cattle. Therefore, revised and new methods are provided here for the detection of anthelmintic resistance in nematodes of ruminants, horses and pigs as a basis for discussion and with the purpose that they are evaluated internationally to establish whether they could in the future be recommended by the WAAVP. The interpretation of the faecal egg count reduction test has been modified and suggestions given on its use with persistent anthelmintics and continuous release devices. An egg hatch test for benzimidazole (BZ) resistance is described. A ...
While surveys in Southern Africa indicate anthelmintic resistance of gastrointestinal nematodes to be common in small ruminants in South Africa, Kenya and Zimbabwe, there have been no reports of resistance in Zambia. The objective of this study was to determine whether anthelmintic resistance occurs in Zambia, and to obtain information on nematode control practices in the country. During the rainy season six commercial sheep farms were selected in and around Lusaka and Chisamba. Worm control practices were gauged by means of a questionnaire, and the Faecal Egg Count Reduction Test was performed for assessing anthelmintic efficacy of albendazole, levamisole and ivermectin. On all farms, anthelmintic treatment was the only approach used to control nematode infections. Frequency of treatment varied from twice a year to every 6 weeks and drugs of different anthelmintic groups were alternated within the same year. There was a wide range in faecal egg counts of individual sheep before treatment, with ...
AIM: To provide information on current farmers opinions and farming practices thought to be related to anthelmintic resistance, and to test for associations between the presence of anthelmintic resistance and management practices on beef cattle-rearing farms in the North Island of New Zealand. METHODS: A study using an interview-based questionnaire about management of internal parasites was conducted on 62 beef cattle-rearing farms in the North Island of New Zealand, using case-control analyses to test for associations between management practices and the presence or absence of resistance to ivermectin or albendazole. Resistance was inferred from faecal nematode egg count (FEC) reduction (FECR) tests (FECRTs) when there was ,90% reduction in FEC 7-10 days after treatment of calves ,12 months of age. RESULTS: Of the 59 farmers who completed the questionnaire, most (n=40) ranked parasites highly, and at about the same level as quality and quantity of feed, as important production-limiting factors ...

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors - Full Text View - ClinicalTrials.govPhase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors - Full Text View - ClinicalTrials.gov

6 Pregnant women are excluded because mebendazole is a Class C agent with the potential for teratogenic effects. Because it is ... Antinematodal Agents. Anthelmintics. Antiparasitic Agents. Anti-Infective Agents. Tubulin Modulators. To Top ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02644291

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An antinematodal agent is a type of anthelmintic designed to reduce nematode infection. Antinematodal agent at the US National ...
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Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children ...
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Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children ...
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    Results of search for su:{Antinematodal agents}WHO HQ Library catalog › Results of search for 'su:{Antinematodal agents}'

Book; Format: print Publisher: Genève : Organisation mondiale de la Santé, 2004Title translated: Prevention and control of schistosomiasis and soil-transmitted helminthiasis : report of a WHO expert committee.; Prevención y control de la esquistosomiasis y las helmintiasis transmitidas por el suelo : informe de un comité de expertos de la OMS..Online access: Full text now in IRIS Availability: Items available for loan: WHO HQ [Call number: DC.HQ SERIAL] (2). ...
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1 result(s) search for keyword(s) Antinematodal Agents Add the result to your basket Refine your search Generate the RSS feed ... Ivermectin Antinematodal Agents Parasites Comparative Study. Abstract: Purpose: This study was designed to evaluate the ... Ivermectin Antinematodal Agents Parasites Comparative Study. Abstract: Purpose: This study was designed to evaluate the ...
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PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) - Full Text View - ClinicalTrials.govPK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) - Full Text View - ClinicalTrials.gov

Antiparasitic Agents. Anthelmintics. Anticestodal Agents. Antiplatyhelmintic Agents. Antiprotozoal Agents. Tubulin Modulators. ... Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of Pharmacological Action. Antineoplastic Agents. Filaricides. ... Anti-Infective Agents. Spirurida Infections. Secernentea Infections. Nematode Infections. Helminthiasis. Parasitic Diseases. ...
more infohttps://clinicaltrials.gov/ct2/show?cond=%22Elephantiasis%22&intr=%22Anti-Infective+Agents%22&rank=29

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Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti-Inflammatory Agents. Filaricides. Antinematodal Agents. ... Antiparasitic Agents. Anti-Infective Agents. Antimalarials. Antirheumatic Agents. Anti-Inflammatory Agents, Non-Steroidal. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT01718054

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Identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, Bursaphelenchus ... Despite the availability of several preventive trunk-injection agents, no therapeutic trunk-injection agent for eradication of ... U. maydis is a biotrophic fungal pathogen and the causal agent of corn smut on maize. This disease is responsible for ... Therefore, it is essential to identify new targets and pathways critical for the causative agent of the tuberculosis, ...
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It is used as an antinematodal agent and an intermediate in the preparation of sodium thiophenolate, pentachlorothiophenol and ...
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ANTINEMATODAL AGENTS. Synthesis Plan * FORMULA:C26H46N2O5. SMILES: C[[email protected]](C(=O)O[[email protected]@]12CC[[email protected]@](C(=O)O)(NC=CN1)O2)C(C)(C)C(C)(C) ...
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ANTINEMATODAL AGENTS. Synthesis Plan * FORMULA:C19H23FN2O. SMILES: C[[email protected]]12C=C[[email protected]]3C[[email protected]]1CN[[email protected]]2(C)[[email protected]]3C(=O)NCc1cccc(F)c1 ...
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  • Using this HTS method, we screened 206 compounds with known activities, mostly antifungal, for antinematodal activities and identified HWY-4213 (1-n-undecyl-2-[2-fluorphenyl] methyl-3,4-dihydro-6,7-dimethoxy-isoquinolinium chloride), a highly water-soluble protoberberine derivative, as a potent nematicidal and antifungal agent. (jove.com)
  • Our study marks a technical breakthrough by developing a novel HTS method that leads to the discovery HWY-4213 as a dual-acting antinematodal and antifungal compound. (jove.com)
  • It is a potent inhibitor of microtubule assembly and DNA topoisomerase II and it is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. (bocsci.com)