Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Used formerly as antimicrobial food additive. It causes mutations in many cell cultures and may be carcinogenic.
A plant genus in the family BERBERIDACEAE. Oregon Grape was discovered in North America and classified by Pursh as a BERBERIS but Nuttall claimed it is different enough to call it a new genus, MAHONIA. Now botanists insist on Berberis while horticulturists stay with this genus. It is a source of BERBERINE.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A plant genus of the family FABACEAE that contains butrin and isobutrin.
Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Essential dietary elements or organic compounds that are required in only small quantities for normal physiologic processes to occur.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Intellectual or mental process whereby an organism obtains knowledge.
Microscopic study of the spacial distribution pattern of CHROMATIN in CELL NUCLEI and CELL NUCLEOLI.
A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the UTERINE CERVIX.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
A large class of organic compounds having more than one PHENOL group.
Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.
5,7,4'-trihydroxy-flavone, one of the FLAVONES.
A group of phenyl benzopyrans named for having structures like FLAVONES.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
A tree of the family Sterculiaceae (or Byttneriaceae), usually Theobroma cacao, or its seeds, which after fermentation and roasting, yield cocoa and chocolate.
Detailed account or statement or formal record of data resulting from empirical inquiry.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Sequential operating programs and data which instruct the functioning of a digital computer.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The removal of a carboxyl group, usually in the form of carbon dioxide, from a chemical compound.
An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.
The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.
The fertilizing element of plants that contains the male GAMETOPHYTES.
Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.
The medical use of honey bee products such as BEE VENOM; HONEY; bee pollen; PROPOLIS; and royal jelly.
A plant genus of the family CISTACEAE. The common name of rock rose is also sometimes used with the closely related Helianthemum genus (CISTACEAE).
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
A growth from a pollen grain down into the flower style which allows two sperm to pass, one to the ovum within the ovule, and the other to the central cell of the ovule to produce endosperm of SEEDS.

Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. (1/241)

Epigallocatechin gallate (EGCG) is a major water-soluble component of green tea. The antimutagenic activity of EGCG against benzo[a]pyrene (B[a]P)-induced mutations was assessed by using transgenic mice carrying the rpsL gene as a monitor of mutations. Seven-week-old male mice were given drinking water containing EGCG for 3 weeks. On day 7, mice were treated with a single i.p. injection of B[a]P (500 mg/kg body wt). Two weeks after the injection, the mutations in the rpsL gene were analyzed. B[a]P treatment resulted in an approximately 4-fold increase of mutation frequency at the rpsL gene in the lung. An approximately 60% reduction in the B[a]P-induced mutations in the lung was observed when mice were given EGCG at concentrations >0.005%. B[a]P-induced mutations mainly occurred at G:C basepairs in the several specific nucleotide sequences of the rpsL gene. These were AGG, CGG, CGT, TGG, TGC and GGT: all of them contained a guanine residue. Mutations seen similarly in the human Ki-ras codon 12 or p53 codons 157, 248, and 273 of lung tumor were also found in the rpsL gene, and the mutations were suppressed by the EGCG treatment. In conclusion, the antimutagenic effects of EGCG for B[a]P-induced mutagenesis in vivo suggest that drinking green tea may reduce the tumor-initiating potency of B[a]P in the lung.  (+info)

Antimutagenicity of sweetpotato (Ipomoea batatas) roots. (2/241)

Antimutagenicity of the water extracts prepared from the storage roots of four varieties of sweetpotato with different flesh colors was investigated using Salmonella typhimurium TA 98. The extract from the whole roots of the purple-colored Ayamurasaki variety effectively decreased the reverse mutation induced not only by Trp-P-1, Trp-P-2, IQ, B[a]P, and 4-NQO but also by dimethyl sulfoxide extracts of grilled beef. Comparison of the inhibitory activity of the extracts from the normal Ayamurasaki and its anthocyanin-deficient mutant one suggested that the anthocyanin pigment in the flesh decreases the mutagenic activity of the mutagens as heterocyclic amines. Two anthocyanin pigments purified from purple-colored sweet-potato, 3-(6,6'-caffeylferulylsophoroside)-5-glucoside of cyanidin (YGM-3) and peonidin (YGM-6) effectively inhibited the reverse mutation induced by heterocyclic amines, Trp-P-1, Trp-P-2, and IQ in the presence of rat liver microsomal activation systems.  (+info)

Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues. (3/241)

The mechanisms involved in the modulation of genotoxic and related effects by carotenoids and vitamin A were inferred from a critical review of an ad hoc constructed database. Almost 500 results were generated in experimental models evaluating the activity of 32 structurally, metabolically and functionally related nutrients, including beta-carotene and 26 other carotenoids, retinol, retinal, all-trans-retinoic acid and retinyl esters. As many as 67 experimental test systems, either in vitro or in vivo, used a variety of cellular targets and/or end-points suggestive of distinctive mechanisms of action. The bulk of available data support the view that carotenoids and vitamin A do not induce genotoxic effects per se. Even in the absence of any genotoxic agent, these nutrients appeared, on the contrary, to display some mechanisms which play protective roles in tumor promotion and progression, such as inhibition of N-myc gene expression resulting in antiproliferative effects, up-regulation of cell-to-cell communication, an increase in connexin 43 gene expression, a decrease in the 'spontaneous' cell transformation frequency and induction of differentiation in vitro. A large number of studies investigated the modulation by carotenoids and vitamin A of genotoxic and related effects produced by 69 genotoxicants, including biological agents, physical agents, chemical compounds and complex mixtures. In spite of some discrepant data, the general trend was that both carotenoids and vitamin A are poorly effective in acting as nucleophiles, nor do they appear to substantially interfere with the induction or repair of DNA damage produced by direct-acting agents. In contrast vitamin A and carotenoids, irrespective of their provitamin A role, in most studies inhibited those genotoxicants which require metabolic activation to electrophilic derivatives in either bacterial or mammalian cells. Coupled with biochemical data, the distinctive patterns observed with genotoxic agents belonging to different chemical classes suggest a complex modulation of both phase I and phase II enzymes involved in the metabolism of xenobiotics. Furthermore, carotenoids and vitamin A shared other protective mechanisms, such as scavenging of genotoxic oxygen species, modulation of signal transduction pathways, inhibition of cell transformation induced by physical and chemical agents, and facilitation of intercellular communication inhibited by genotoxic compounds. Therefore, carotenoids and vitamin A appear to work via multiple mechanisms, which would support a potential protective role in cancer initiation and in the pathogenesis of other mutation-related diseases. These conclusions are consistent with the recognized cancer-preventive activity of these nutrients in certain animal models and with the evidence provided by observational epidemiological studies, which suggested cancer-protective effects at many sites as related to their dietary intake or plasma levels. However, all these lines of evidence and mechanistically based premises contrast with the unexpected outcome of recent clinical intervention trials, which raised the concern that supplemental use of beta-carotene and vitamin A may increase the risk of lung cancer amongst high risk individuals such as tobacco smokers and asbestos-exposed workers.  (+info)

Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli. (4/241)

The spectrum of mutations induced by cobalt(II) chloride (CoCl2) was examined using plasmid pUB3 DNA, which was propagated after transfection into Escherichia coli SY1032/pKY241 host cells. The vector plasmid carried an E.coli supF suppressor tRNA gene as a target for mutations. After CoCl2 treatment, 64 independent nalidixic acid-resistant, ampicillin-resistant and Lac+ (SupF-) clones were obtained and the altered sequences of the mutated supF genes were determined. Deletions and frameshifts were the predominant mutational event (61%) induced by CoCl2 and base substitutions were induced to a lesser degree (29%). Analysis of sequence alterations at all the sites of mutation revealed that: (i) 18 of 19 base substitutions and eight of 10 frameshifts occurred at G:C sites, suggesting that the formation of N7G-Co(II) adducts may be responsible for premutagenic lesions of these mutations; (ii) short sequence repeats were mostly found at the sites of deletions and frameshifts. Slippage-misalignment is also suggested to be a mechanism for the induction of mutations at these sites.  (+info)

Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. (5/241)

Benzyl isothiocyanate (BITC) is contained in cruciferous plants which are part of the human diet. Numerous reports indicate that BITC prevents chemically induced cancer in laboratory animals and it has been postulated that BITC might also be chemoprotective in humans. On the other hand, evidence is accumulating that this compound is a potent genotoxin in mammalian cells by itself. To further elucidate the potential hazards of BITC, we investigated its genotoxic effects in different in vitro genotoxicity tests and in animal models. In in vitro experiments [differential DNA repair assay with Escherichia coli, micronucleus assay with human HepG2 cells and single cell gel electrophoresis (SCGE) assay with hepatocytes and gastrointestinal tract cells] pronounced dose-dependent genotoxic effects were found at low dose levels (+info)

Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. (6/241)

Centchroman (CC), a non-steroidal oral contraceptive and a candidate drug for breast cancer, has been reported to exhibit partial to complete remission of lesions in 40.5% of breast cancer patients. The potent anti-oestrogenic activity, negligible side-effects and anti-breast cancer activity of CC prompted us to evaluate the antimutagenic effects of this compound in a bacterial mutagenicity assay and CHO/HPRT and AS52/GPT mutation assays in vitro and in vivo in female Swiss albino mice as measured by both sister chromatid exchange (SCE) and chromosome aberrations (CA) against three known positive mutagen compounds, dimethylbenz[a]anthracene (DMBA), cyclophosphamide (CP) and mitomycin C (MMC). Antimutagenicity assays in Salmonella strains TA97a, TA100, TA98 and TA102 were carried out against commonly used known positive mutagens, sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significantly reduced number of bacterial histidine revertant colonies was observed in the plates treated with 0.1, 1, 5 and 10 microg/plate CC and a positive compound when compared with bacterial plates treated with the respective positive compound alone. Ethyl methanesulfonate (EMS), a commonly used positive mutagen for CHO/HPRT and AS52/GPT gene mutation assays, was used for antimutagenicity assay in these cells. CC exhibited protective effects against the mutagenicity of EMS in these two mammalian cell mutation assays, CHO/HPRT and AS52/GPT. In the in vivo studies, pretreatment with CC reduced DMBA-induced SCE and CA and CP- and MMC-induced CA when compared with the group treated only with the positive compounds. These results indicate that CC can reduce the mutagenic effects of known genotoxic compounds.  (+info)

Simple chemicals can induce maturation and apoptosis of dendritic cells. (7/241)

As is well known in the case of Langerhans cells, dendritic cells (DCs) play a crucial role in the initiation of immunity to simple chemicals such as noted in the contact hypersensitivity. Because DCs are scattered in non-lymphoid organs as immature cells, they must be activated to initiate primary antigen-specific immune reactions. Therefore, we hypothesized that some simple chemicals must affect the function of DCs. In this paper, we first demonstrated that human monocyte-derived DCs responded to such simple chemicals as 2, 4-dinitrochlorobenzene (DNCB), 2,4,6-trinitrochlorobenzene (TNCB), 2, 4-dinitrofluorobenzene (DNFB), NiCl2, MnCl2, CoCl2, SnCl2, and CdSO4 by augmenting their expression of CD86 or human leucocyte antigen-DR (HLA-DR), down-regulating c-Fms expression or increasing their production of tumour necrosis factor-alpha (TNF-alpha). In addition, the DCs stimulated with the chemicals demonstrated increased allogeneic T-cell stimulatory function. Next, we found that, among these chemicals, only NiCl2 and CoCl2 induced apoptosis in them. Finally, we examined the effects of these chemicals on CD86 expression by three different macrophage subsets and DCs induced from the cultures of human peripheral blood monocytes in the presence of macrophage colony-stimulating factor (M-CSF), M-CSF + interleukin-4 (IL-4), granulocyte-macrophage colony-stimulating factor (GM-CSF), and GM-CSF + IL-4, respectively. Among them, only DCs dramatically augmented their expression of CD86. These observations have revealed unique characteristics of DCs, which convert chemical stimuli to augmentation of their antigen presenting function, although their responses to different chemicals were not necessarily uniform in the phenotypic changes, cytokine production or in the induction of apoptosis.  (+info)

Modification of mutagenic activities of pro-mutagens by glyco-ursodeoxycholic acid in the Ames assay. (8/241)

Mutagenicity, co-mutagenicity and anti-mutagenicity of glycoursodeoxycholic acid (GUDCA) were examined by the Ames assay using Salmonella typhimurium strain TA98 with S9. As pro-mutagens, 2-aminoanthracene (2AA), Benzo[a]pyrene (BaP), 3-amino-1-dimethyl-5H-pyrido[4, 3-b]indole (Trp-P-2), 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) and 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline (MeIQ) were used. In addition to these pro-mutagens, blue-chitin extracts of human gallbladder bile (BCE) collected from the cholecystectomized patients with cholelithiasis were used in order to investigate the role of GUDCA on mutagen(s) actually existing in human bile. It was found that GUDCA did not show mutagenicity in this test system. Concerning the modification of mutagenic activities of pro-mutagens, GUDCA showed the different directions. GUDCA acted as co-mutagen, since it enhanced the mutagenic activities of 2AA and BaP. But, acted as anti-mutagen, since it suppressed the activities of Trp-P-2, IQ and MeIQ, all of which were classified as heterocyclic amines. GUDCA also suppressed the mutagen(s) in human bile. Because of the use of blue-chitin absorbed method for testing bile mutagenicity, the chemicals involved were considered to be heterocyclic amines and other polycyclic compounds. In these we suspect the bile mutagens are heterocyclic amines. Further examination should be directed towards the investigation into the mechanism of anti-mutagenic effects of GUDCA on mutagen(s) actually existing in human bile.  (+info)

24 A study investigated anti-mutagenic. activity of H. antidysenterica, where methanolic bark extract of the plant demonstrated anti-mutagenic potency in sodium azide and methyl methane sulphonate induced mutagenicity in Salmonella typhimurium strains. 25 Plants with anti-hypertensive activity are investigated on their ability to inhibit the secretion of angiotensin, which causes vasoconstriction leading to increased blood pressure. Ethanolic seed extracts showed a satisfactory 24% angiotensin-converting enzyme (ACE) inhibition.26 Bark extracts tested for in vitro and in vivo anti-malarial Luminespib in vivo activity against Plasmodium falciparum isolates and P. berghei infected Swiss mice respectively, showed significant results. 27 Chloroform bark extract demonstrated the greatest anti-plasmodial activity, with an average IC50 value of 5.7 μg/ml in the in vitro experiment and 70% suppression of parasitaemia in the in vivo experiment when administered at 30 mg/kg. 27 Most of the known chemical ...
TY - JOUR. T1 - Mutagenic and antimutagenic effects of methanol extracts of unfermented and fermented black soybeans. AU - Hung, Yu Hsiang. AU - Huang, Hui Yu. AU - Chou, Cheng Chun. PY - 2007/8/15. Y1 - 2007/8/15. N2 - In this study, solid fermentation of steamed black soybean with various GRAS (Generally recognized as safe) filamentious-fungi including Aspergillus awamori, Aspergillus oryzae BCRC 30222, Aspergillus sojae BCRC 30103, Rhizopus azygosporus BCRC 31158 and Rhizopus sp. No. 2 was performed. Mutagenicity and antimutagenicity of the methanol extracts of unfermented and fermented steamed black soybeans against 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen and Benzo[a]pyrene (B[a]P), an indirect mutagen, on Salmonella Typhimurium TA100 and TA 98, were examined. The methanol extracts of unfermented and fermented steamed black soybeans show no mutagenic activity for either test strains at the doses tested. The extracts inhibited mutagenesis by either 4-NQO or B[a]P in S. Typhimurium ...
β-glucan is an important polysaccharide due to its medicinal properties of stimulating the immune system and preventing chronic diseases such as cancer. The aim of the present study was to determine the anticlastogenic effect of β-glucan in cells e
Antimutagens are the agents that interfere with the mutagenicity of a substance. The interference can be in the form of prevention of the transformation of a mutagenic compound into mutagen[clarification needed], inactivation, or otherwise the prevention of Mutagen-DNA reaction. Antimutagens can be classified into: Desmutagens, that inactivate the chemical interactions before the mutagen attacks the genes and Bio-antimutagens, that stop the mutation process once after the genes are damaged by mutagens. There are a number of naturally occurring anti-mutagens that show their efficient action. Nutrients such as vitamins and minerals are examples of micronutrients that are necessary for the proper maintenance of metabolism homeostasis in humans and other species. Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the examples below): Carotenoids: Induction of single break DNA repair by a rejoining mechanism and elimination of ...
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RSKK 02029. The MIC was evaluated on plant extracts as antimicrobial activity. All of bacterial strains showed the lowest sensitivity to methanol extract of E. angustifolia (3.5 mg/mL), except Yersinia enterocolitica NCTC 11174. In addition, the plant extracts were tested against the stable DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free-radical. Finally, the methanol extract displayed a strong antioxidant activity (Trolox equivalent = 1.49 mM). Also, E. angustifolia methanol extracts were screened for their antimutagenic activity against sodium azide by Ames test in absence of rat microsomal liver enzyme (-S9). The results showed that E. angustifolia methanol extracts can inhibit mutagenic agents of sodium azide. The plant leaf extracts with the inhibition of 36% sodium azide showed moderate potential in decreasing mutagenic agents in Salmonella typhimurium ...
The aim of the present study was to investigate the antimutagenic effects of chrysin (CR), a flavonoid compound contained in many fruits, vegetables and honey. Earlier investigations with bacterial indicators showed that CR is one of the most potent antimutagens among the flavonoids. In the present study, we tested the compound in the Salmonella strains TA98 and TA100 in combination with benzo(a)pyrene (B(a)P) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and found pronounced protective activity over a concentration range between 10 and 100 microg/ml. The compound itself was devoid of mutagenic activity at all concentrations tested. In the micronucleus (MN) assay with human-derived HepG2 cells, a different pattern of activity was seen. CR itself caused significant induction of MN at dose levels > or =15 microg/ml; in combination experiments with B(a)P and PhIP, U-shaped dose-response curves were obtained and protection was found only in a narrow dose range (5 - 10 microg/ml). Our ...
Flavonoids are part of the healthy polyphenol family of chemicals which occur in plants. There are more than 4000 different flavonoids, mostly in fruits, vegetables and seeds. We eat about 1,000 mg. of flavonoids per day. Numerous health benefits have been discovered in flavonoids, including anticancer, anti-mutagenic (prevention of mutations), antioxidant, and antiviral properties. Flavonoids […]. View Post ...
Introduction and objective: The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. In view of the high incidence of cancer the aim of this article was to...
Mannr ttindaskrifstofa slands var stofnu Almannagj ingv llum hinn 17. j n 1994, fimmt u ra afm li slenska l veldisins. Skrifstofan er h stofnun sem vinnur a framgangi mannr ttinda me v a stu la a ranns knum og fr slu og efla umr u um mannr ttindi slandi. ...
Toxicol In Vitro. 2016 Feb 15. pii: S0887-2333(16)30020-0. doi: 10.1016/j.tiv.2016.02.005.. Evaluation of the genotoxicity/mutagenicity and antigenotoxicity/antimutagenicity induced by propolis and Baccharis dracunculifolia, by in vitro study with HTC cells.. Author information. Roberto MM1, Matsumoto ST2, Jamal CM3, Malaspina O4, Marin-Morales MA5.. Abstract. The ethanolic extract of propolis, especially the Brazilian green type, is widely and mainly used for therapeutic purposes despite the lack of knowledge about its effects and its cellular mode of action. This type of propolis, derived from Baccharis dracunculifolia (alecrim-do-campo), has been extensively commercialized and the consumers use it to enhance health. This work aimed to assess the genotoxic/mutagenic and antigenotoxic/antimutagenic potentials of the ethanolic extracts of Brazilian green propolis and of B. dracunculifolia, on mammalian cells. It was not observed genotoxic and mutagenic effects by both extracts. After evaluate ...
The health benefits of natural products have long been recognized. Consumption of dietary compounds such as supplements provides an alternative source of natural products to those obtained from the diet. There is a growing concern regarding the possible side effects of using different food supplements simultaneously, since their possible interactions are less known. For the first time, we have tested genotoxic and antigenotoxic effects of Biochaga, in combination with dihydroquercetin. No genotoxic effect on whole blood cells was observed within individual treatment of Biochaga (250 μ g/mL, 500 μ g/mL and 1000 μ g/mL) and dihydroquercetin (100 μ g/mL, 250 μ g/mL and 500 μ g/mL), nor in combination. Afterwards, antigenotoxic potency of both supplements against hydrogen peroxide- (H 2 O 2 -) induced DNA damage to whole blood cells (WBC) was assessed, using the comet assay. Biochaga and dihydroquercetin displayed a strong potential to attenuate H 2 O 2 -induced damage on DNA in cells at ...
Introduction. The relation between diet and health has been widely recognized by many people throughout the centuries. However, the relationship between diet and cancer has been pointed out only in the last decades (De Marini, 1998). As a consequence, diet in general is considered to be the largest source of mutagenic and carcinogenic substances for human beings. Various studies, including those using short-term assays, have helped to identify a great number of antimutagenic properties found in some foods such as: b-carotene, ascorbic acid, linoleic acid, a-tocopherol, vanillin, chlorophyllin, polyphenols and components found in black and green teas and mushrooms (Brockman et al., 1992; Lohman et al., 2001). For this reason, the finding of these substances in natural foods is extremely important not only due to their nutritional value but also as a prophylactic agent against diseases such as cancer (Ferguson, 1994).. Although various mushrooms are used nowadays as a medicine or food in some ...
MW 724.15, Purity | 98%. Antioxidant, antimutagenic agent. Shows antimutagenic effects against a range of mutagenic agents but potentiates the mutagenic effects of alkylating agents. Shows…
An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B1, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB1 and proliferation of a cancer cell line.
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TY - JOUR. T1 - Prevention by N-acetylcysteine of benzo[a]pyrene clastogenicity and DNA adducts in rats. AU - De Flora, Silvio. AU - DAgostini, Francesco. AU - Izzotti, Alberto. AU - Balansky, Roumen. PY - 1991. Y1 - 1991. N2 - The daily i.t. administration of benzo[a]pyrene (BP) to Sprague-Dawley rats, for 3 consecutive days, did not cause any toxicity or clastogenicity in bone marrow cells, as evaluated by monitoring the ratio of polychromatic to normochromatic erythrocytes and the frequency of micronucleated polychromatic erythrocytes. However, BP produced a considerable enhancement of binucleated and micronucleated pulmonary alveolar macrophages, as well as a significant increase in polymorphonucleates recovered by bronchoalveolar lavage. These effects were prevented by administering the thiol N-acetylcysteine (NAC) by gavage 5 h before each BP instillation. In addition, the i.t. treatment with BP resulted in the formation of BP diolepoxide (BPDE)-DNA adducts in lungs and liver, as assessed ...
Chlorophyllin is the name for a group of chemicals similar to chlorophyll, well-known for photosynthesis and the green in leaves. The most common variety has a structure made of sodium and copper. Chlorophyllin can be used for reducing internal and external body odors, and its value as a health supplement comes from the fact that chlorophyllin binds to mutagens like cancer and possibly help in removing them. It does so on a level of magnitude higher than other cancer-preventative chemicals like resveratrol.. ...
Chlorophyll is a pigment found in green plants, which is vital for photosynthesis allowing plants to absorb energy from light. Chlorophyll, or more specifically the natural derivative, Sodium Copper Chlorophyllin offers many promising skin benefits.. Sodium Chlorophyllin Copper Complex can be found in topical enzymatic medications used for healing-debriding wounds. Chlorophyllin Copper Complex Sodium, expedites the healing of wounds by slowing the growth of certain bacteria on the skin, controls local inflammation and aids in the promotion of healthy granulations. It works to inhibit the inflammatory properties of protein degradation products in the wound, including the products of enzymatic digestion.. Hyaluronic acid is naturally occurring in the human body. It has the ability to bind to and hold about a thousand times its weight in water. In the dermal layers of the skin it provides moisture, plumpness, firmness and suppleness to the skin. With age, the production of hyaluronic acid in the ...
Synonyms for Caraway Oil in Free Thesaurus. Antonyms for Caraway Oil. 1 synonym for caraway: Carum carvi. What are synonyms for Caraway Oil?
Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress induced by cisplatin (cDDP) are modulated by a combination of the natural pigments lutein (LT) and chlorophyll b (CLb). The protective effects observed for synergism between phytochemicals have not been completely investigated. The comet assay and micronucleus test were performed and the catalase activities and glutathione (GSH) concentrations were measured in the peripheral blood, bone marrow, liver, and kidney cells of mice. The comet assay and micronucleus test results revealed that the pigments LT and CLb were not genotoxic or mutagenic and that the pigments presented antigenotoxic and antimutagenic effects in the different cell types evaluated. This protective effect is likely ...
Sodium Magnesium Chlorophyllin is a dark green powder that is easily soluble in water and slightly soluble in alcohol. Sodium Magnesium Chlorophyllin is...
The basic cancer-related chemical and biological sciences, pathology, and epidemiology have contributed to the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and to the development of antimutagenic and anti-proliferative agents as potential chemopreventive drugs. These disciplines have also provided the biochemical and histopathological bases for identifying intermediate biomarkers that can be used as surrogate end points for cancer incidence in clinical chemoprevention trials and for selecting cohorts for these trials. Particularly important as histological biomarkers of cancer are the cytonuclear morphological and densitometric changes that define intraepithelial neoplasia (IEN). IEN changes are on the causal pathway to cancer. They may serve as target lesions in Phase II chemoprevention trials and as standards against which other earlier cellular and molecular biomarkers can be evaluated. Strategies for the clinical evaluation ...
Shams Eldien Koko, Talib M. A., Fatima Elfatih, Eman M. Zain Alabdeen and Ahmed S. Kabbashi*. ABSTRACT. Balanites aegyptiaca has been reported to be an anti-helminthic, a purgative, febrifuge, emetic and can also cure other types of ailments like skin boils, malaria, wounds, colds, syphilis, liver and spleen disorders. Various parts of this plant have their own traditional medicinal properties. The seed is used as a febrifuge, and its oil is used to treat tumors and wounds. An aqueous extract of the bark is used in Sudanese folk medicine in the treatment of jaundice. The kernel oil exhibited anticancer activity against lung, liver, and brain carcinoma cell lines. It also has anti-mutagenic activity against Fasciola gigantica-induced mutagenicity besides anthelmintic activity against hepatic worms (Schistosoma mansoni), the aqueous leaf extract and saponins isolated from its kernel cakes have antibacterial activity. The branches are used as tooth brush. The root extracts have proved to be ...
Shams Eldien Koko, Talib M. A., Suliman I. Suliman, Muddathir S. Alhassan and Ahmed S. Kabbashi*. ABSTRACT. Balanites aegyptiaca has been reported to be an anti-helminthic, a purgative, febrifuge, emetic and can also cure other types of ailments like skin boils, malaria, wounds, colds, syphilis, liver and spleen disorders. Various parts of this plant have their own traditional medicinal properties. The seed is used as a febrifuge, and its oil is used to treat tumors and wounds. An aqueous extract of the bark is used in Sudanese folk medicine in the treatment of jaundice. The kernel oil exhibited anticancer activity against lung, liver, and brain carcinoma cell lines. It also has anti-mutagenic activity against Fasciola gigantica-induced mutagenicity besides anthelmintic activity against hepatic worms (Schistosoma mansoni), the aqueous leaf extract and saponins isolated from its kernel cakes have antibacterial activity. The branches are used as tooth brush. The root extracts have proved to be ...
1. Saleem, Mohammad, Kaur, SJ, Kweon, Mee-Hyang, Adhami, Vaqar Mustafa, Afaq, Farrukh, and Mukhtar, Hasan (2005). Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway, Carcinogenesis, 26(11), pp 1956-1964. 2. Sondhi, Nishi, Bhardwaj, Renu, Kaur, SJ, Singh, Bikram and Kumar, Neeraj (2008) Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity potential employing Allium cepa chromosomal aberration assay Plant Growth Regulators, 54, pp 217-224 : 3. Singh,Palwinder, Mittal, Anu, Kaur, SJ., Holzer, W. and Kumar, Subodh (2008) 2,3- Diaryl-5-ethylsulfanylmethyltetrahydrofurans as new class of COX-2 inhibitors and cytotoxic agents, Organic and Biomolecular Chemistry, 6:2706-2712. 4. Singh, Palwinder, Mittal, Anu, Kaur, SJ,. and Kumar, Subodh (2008) 2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of ...
Noni juice has a tremendous anti-oxidative potential which neutralize their negative effects and diseases caused by oxidative Stress.. Prevents various Cancers such as lung cancer, liver cancer and renal cancer.. Noni juice has inhibitory action on the xanthine oxidase enzymes which treats Gout and its associated problems.. Noni juice helps in alleviating pain thereby, reducing the joint destruction implicated in the painful Arthritis.. Noni juice protects Cardiovascular system reducing the LDL (bad) cholesterol levels, total cholesterol content, homocysteine and improves HDL (good) cholesterol levels in the body.. A Hepato-protective effect of Noni assists in protecting the Liver from exposures to chronic exogenous chemicals.. Noni is effectual in speeding up Wound Healing by increasing in the weight of the granulation tissues, functioning of collagen and protein content.. Noni juice possesses anti-bacterial, anti-mutagenic, anti-inflammatory, antifungal and anti-histamine properties which ...
Noni juice has a tremendous anti-oxidative potential which neutralize their negative effects and diseases caused by oxidative Stress.. Prevents various Cancers such as lung cancer, liver cancer and renal cancer.. Noni juice has inhibitory action on the xanthine oxidase enzymes which treats Gout and its associated problems.. Noni juice helps in alleviating pain thereby, reducing the joint destruction implicated in the painful Arthritis.. Noni juice protects Cardiovascular system reducing the LDL (bad) cholesterol levels, total cholesterol content, homocysteine and improves HDL (good) cholesterol levels in the body.. A Hepato-protective effect of Noni assists in protecting the Liver from exposures to chronic exogenous chemicals.. Noni is effectual in speeding up Wound Healing by increasing in the weight of the granulation tissues, functioning of collagen and protein content.. Noni juice possesses anti-bacterial, anti-mutagenic, anti-inflammatory, antifungal and anti-histamine properties which ...
Methods: In a prospective controlled randomized trial, 18 patients with GBM underwent standard treatment with surgery, chemotherapy, and radiotherapy; nine received an additional 150-mg dose of chloroquine daily starting 1 day after surgery and continued through the observation period. Nine matched patients were included as controls. Neuroimaging studies and clinical response were periodically compared. The follow-up period ranged from 24 to 50 months. Survival time was defined as the main outcome measure. ...
This study evaluated the antioxidative and antiapoptotic effects of chlorophyllin (CHL) on a rat spleen exposed to localized gastric radiotherapy. The stomach region of f..
#123 - CLR - CHLOROPHYLLIN PLUS - This formula is often used as a bacteriostat and soothing agent for relief of inflamed mucus membranes. It provides photosynthetic pigment for mucus membrane balance. High in natural magnesium, it is effective for blood b
Fresh lemon grass fields in Israel become Mecca for cancer patients by Allison Kaplan Sommer - April 02, 2006 A drink with as little as one gram of lemon grass contains enough citral to prompt cancer cells to commit suicide in the test tube. Israeli researchers find way to make cancer cells self-destruct - Ben…
Organic Lemon Grass A150 specifications & features from suppliers/manufacturer Organic Lemon Grass. without herbicide Fine cut 0,4-2mm. Packaging: 20-25kg in bags Or carton . parameters for heavy metals :Copper 3.3 mg/kgCadmium 0.05 mg/kgLead 0.2 mg/kgMercury not detected
Chemopreventive Properties Chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.
100% Pure Caraway Oil,US $ 42 - 45 / Kilogram, OEM/ODM, CE, GMP, MSDS, Pure Essential Oil.Source from SNN NATURAL PRODUCTS on Alibaba.com.
Fresh Lemon Grass Fields In Israel Become Mecca For Cancer Patients. A drink with as little as one gram of lemon grass contains enough citral to prompt cancer cells to commit suicide in the test tube according to new Israeli research. At first, Benny Zabidov, an Israeli agriculturalist who grows greenhouses. By: Allison Kaplan Sommer. A drink with as little as one gram of lemon grass contains enough citral to prompt cancer cells to commit suicide in the test tube according to new Israeli research. At first, Benny Zabidov, an Israeli agriculturalist who grows greenhouses full of lush spices on a pastoral farm in Kfar Yedidya in the Sharon region, couldnt understand why so many cancer patients from around the country were showing up on his doorstep asking for fresh lemon grass.. It turned out that their doctors had sent them.. They had been told to drink eight glasses of hot water with fresh lemon grass steeped in it on the days that they went for their radiation and chemotherapy treatments, ...
Lemon grass (citronella), raw Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
Administration of caraway oil addresses posology; its duration of use; contra-indications; special warnings; special precautions for use; interactions with other medicinal products; other forms of interaction; in pregnancy and lactation; its effects on ability to drive; undesirable effects; overdose ...
The common Caraway is a herb of the umbelliferous order found growing on many waste places in England, though not a true native of Great Britain. Its well-known aromatic seeds should be always at hand in the cupboard of every British housewife.
Find patient medical information for CARAWAY on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.
Turmeric is so powerful because of the wealth of beneficial compounds that are present within it. It has antibacterial, anticarcinogenic, antioxidant, antimutagenic, antifungal, antiviral, and anti-inflammatory properties. It is rich in many healthy nutrients such as iron, dietary fiber, niacin, magnesium, Vitamin C, Vitamin E, Vitamin K, potassium, protein, calcium, copper, and zinc.. Prevents ...
Analgesic FT63(3):195 ; Antialzheimeran JNP61:1212 ; Antiarthritic PM57:A56 ; Anticancer JNP61:1212 ; Anticancer (Colon) JNP61:1212 ; Anticariogenic LAF ; Anticholestatic 28-100 mg/kg orl PR6:74 ; Anticomplement IC100 0.1 mM/l gpg HH2 IC80-90 0.05 mM/l gpg HH2 ; Antidiabetic CCO ; AntiEBV CAN ; Antiedemic; Antifibrosarcomic IC80=10 uM BO2 ; Antihepatotoxic 5-20 mg/kg ipr PR6:74 ; Antihistaminic CPB39:3276 ; AntiHIV EC50=2.0 ug/ml JNP61:1090 IC50=6.5 ug/ml JNP61:1090 IC85=18 ug/ml JNP59:643 ; Antihyperlipidemic JE49:57 ; Antiinflammatory 1/3 indomethacin IC24=500 mg/kg; Antileishmanic ED50=20 uM POP:113 ; Antileukemic JNP53(3):513 ; Antilymphomic CAN ; Antimalarial IC50=28-37 ug/ml PR13:115 ; Antimetastatic IC80=10 uM BO2 ; Antimutagenic PPB17:990 ; Antiobesity? IJO16:4 ; Antioxidant BCI28:735 ; Antiplasmodial IC50=28-37 ug/ml PR13:115 ; Antiproliferative IC50=15-20 uM FT66(4):369 ; Antistaphylococcic CAN ; Antitumor CR54:701 ; Antitumor (Breast) 0.5% diet CLE104:43 IC50=15-20 uM FT66(4):369 ; ...
Lemongrass has many health benefits and healing properties. It is used to treat gastro-intestinal problems stomachaches, diarrhea, gas, bowel spasms
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In the study of the suppressive compounds of methanol extract re-extracted against furylfuramide in the dichloromethane fraction isolated by SiO(2) column chromatography and identified as 7,4′-di-O-methyleriodictyol (1), 7, 3′,4′-tri-O-methyleriodictyol (2), and 3,7,4′-tri-O-methylkaempferol (3) and three flavonoids, ombuine (4), pachypodol (5), and kumatakenin (6), isolated and identified from the dichrolomethane fraction, showed that these compounds were assayed with activated Trp-P-1, and the suppressed effects of these compounds were further decreased when compared to Trp-P-1. The antimutagenic activities of these compounds against furylfuramide, Trp-P-1, and activated Trp-P-1 were assayed by the Ames test using S. typhimurium TA100, according to Antimutagenic activity of flavonoids from Pogostemon cablin by Miyazawa M, Okuno Y, Nakamura S, Kosaka H.(6 ...
Claws claw has been used in folk medicine in South-American history for treatment of cancers, arthritis, gastritis and epidemic diseases. In previous article, Cats claw has exerted its anti breast caner activity in MT-3 cell lines as well as some other forms of cancers, but in other study of some extracts and their chromatographic fractions from Cats claw, researcher found that beside possessed antimutagenic activity, the extracts and fractions also consisted a direct antiproliferative activity on MCF7 cell line, with about 90% of inhibition at a concentration of 100 mg/ml ...
Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental carcinogen, has been isolated from urban air samples, tobacco smoke, and coal smoke condensate. A study was conducted to evaluate the complex interrelationships among dietary DBP doses with co-exposure to a range of CHL doses. In order to achieve adequate statistical power in the generation of multiple dose-response curves, this dose-dose matrix experiment utilized over 12,000 rainbow trout. The resulting DNA adducts were assessed and evaluated as biomarkers of exposure to discern their relationship with the final tumor outcome. CHL was highly effective in reducing DBP-initiated DNA adduct formation in the liver and stomach and strongly inhibited ...
Pain au Levain - Rye with Cracked Rye Soaker and Caraway SeedsThis formula produces an excellent rye bread that tastes great and is good plain ortoasted. With cracked rye soaker and caraway seedsincorporated into the final dough mix, toasting this bread brings out a pleasantand more pronounced rye and caraway taste. The soaker and caraway seeds gives it a good texture and a distinct ryetaste. This is a medium rye,high-hydration dough that produces a rustic type bread with open crumb and nicecolor and crust.Yield: 8 lbs 15 1/4 oz of dough or 4.08 kilograms (4 loaves @ 1kilogram (2.2 lbs) each, or 2 loaves @ 2 kilograms (4.4 lbs) each. This recipe may be halved to produce 2 loaves @1 kilogram (2.2 lbs) each or 1 large miche type loaf @ 2.2 kilograms (4.2 lbs).Time:Ferment: Double levain build (starting with a mature rye starter): 1st levain build 12-14 hours, 2nd levain mix 2.5 - 3 hours for a total of approx. 15 hours prior to final dough mix, depending on room temperatureSoak cracked rye:
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Sweetpotato is an important staple food crop in Sub-Saharan Africa, with production being concentrated in East Africa, particularly around Lake Victoria. Productivity of the crop is greatly constrained by viral diseases. Four main viruses have consistently been detected from various surveys done in the region viz., sweetpotato feathery mottle virus (SPFMV), sweetpotato chlorotic stunt virus (SPCSV), sweetpotato mild mottle virus (Sp.m.MV), and sweetpotato chlorotic fleck virus (SPCFV). The most severe symptoms have been caused by co-infection with SPCSV and SPFMV, resulting in the synergistic sweetpotato virus disease (SPVD). Some local sweetpotato genotypes have been reported to recover from, or have localized distribution of SPVD, suggesting that the disease is not fully systemic. This has led to the suggestion that uninfected cuttings may be obtained from previously infected plants. Experiments were set to determine the possibility of obtaining cuttings long enough for propagation that are ...
Aflatoxin B1 is a contaminant of agricultural and dairy products that can berelated to mutagenic and carcinogenic effects. In this report we explore the capacity of ?-mannan (Man) to reduce the DNA damage induced by AFB1 in mouse hepatocytes. Forthis purpose we applied the comet assay to groups of animals which were firstadministered Man (100, 400 and 700 mg/kg, respectively) and 20 min later 1.0 mg/kg ofAFB1. Liver cells were obtained at 4, 10, and 16 h after the chemical administration andexamined. The results showed no protection of the damage induced by AFB1 with thelow dose of the polysaccharide, but they did reveal antigenotoxic activity exerted by thetwo high doses. In addition, we induced a co-crystallization between both compounds,determined their fusion points and analyzed the molecules by UV spectroscopy. Theobtained data suggested the formation of a supramolecular complex between AFB1and Man ...
Check out our guide to the effects of Kratom strains here. The product quality is going to have some role in the intensity felt but most people feel its power. This is amount is typically regarded as extremely is kratom safe to drink powerful for an extract.. David Aardvark editor. Kratom Side Effects Heart Floresville this enlarged second edition contains a veritable treasure-trove of useful information. New endnotes provide fresh commentary and bring the text up-to-date.. Many people experience dream-like closed-eye visuals. Strong doses must only be used when one can devote several hours to the experience itself. This herb is extremely rare outside of its native region in Southeast Asia.. Antioxidant antiviral anti-mutagenic anti-leukemic anti inflammatory anti-diabetic. Commonly found in green tea. Kratom dosage has been a key factor for those looking for specific effects.. Leaf alkaloid content can vary from plant to plant and from strain to strain however super malay kratom review there ...
Deals, coupons, events, images, phone number, directions, and whats nearby Caraway Drug, a drug store business at 116 E Kentucky St, Caraway, AR 72419 on Fave.
TY - JOUR. T1 - Inhibitory effect of chlorophyllin derivatives on genotoxicities of various carcinogens in Drosophila.(共著). AU - Negishi, Tomoe. PY - 1991. Y1 - 1991. M3 - Article. VL - 253. SP - 265. EP - 266. JO - Mutation Res.. JF - Mutation Res.. ER - ...
Our Caraway fennel with L-glutamine sauerkraut is 100% vegan which is made from the naturally occurring bacteria already present on the organic cabbage by the process of wild-fermentation without using vinegar. Green cabbage, onions, and Caraway seeds are very high in vitamin C, fiber, water content, and good for decre
Detailed nutritional values of Cheese, caraway type. Online analysis information with non-nutrients and nutrients composition facts table for item No. 01008 found in category Dairy and Egg Products. Data contents chart for nutritionists. Food details for CHEESE,CARAWAY in different kinds of quantities, amounts or measurements.
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Slukvin A.M.; Goncharova R.I.; Duburs G.J.; Uldrikis J.R.; Bisenieks E.A. Protective effects of Diludine on reproductive activity, development and cytogenetic variability of Cyprinus carpio L. Proceedings, Eighth International conference on Mechanisms of antimutagenesis and anticarcinogenesis; 4-8 October; G.Bronzetti, L.R.Ferguson, S.De Flora, Eds.; : Pisa, Italy, 2003; 131 ...
Caraway Seeds Maximize the Outcome of Forskolin. Getting Forskolin with caraway seed get or oil causes it to be even more productive. Caraway plant seeds have the capability to restrain starvation. Create a tea with caraway seeds and just take it with your Forskolin, so you will identify an outstanding higher surge in the metabolic demand. You are going to not feeling starving and may be competent at stick with your eating plan prepare. Caraway and Forskolin along with one other will get rid of the various hard to clean body fat of your respective specific body.. Right Dose Will Provide the Correct Results. Choosing the best dosage may be somewhat tricky. Plenty of reviews have been totally understand the most efficient medication dosage, however it has become observed the exact affect may differ from 1 specific to a new. Some tests happen to be performed with 100 20 or so five milligrams of 20% Forskolin for each day time, while many happen to be carried out with 250 milligrams of ten percent ...
This site provides a venue for sweetpotato scientists, practitioners, and farmers to share, discuss, and generate new knowledge. Information is also available for the general public to learn more about sweetpotato. The goal is to build a vibrant community of practice, providing easy access to technical and scientific information concerning sweetpotato. Anyone who registers can contribute to the site. Together we will work to enhance nutrition and food security for millions of people ...
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Rapeseed and its oil are the source of many biologically active compounds, especially phenolic compounds that have been confirmed to have antioxidant, antimutagenic and anticancer activity. From crude oil is isolated 4-vinyl-2,6-dimethoksiphenol or canolol and from edible oil its dimer, phenylindan. In this study, we tested the biological activity of these compounds by determination of the antioxidant capacity by ORAC method and in vitro cytotoxicity in human tumor cell lines (MCF-7, HeLa) and in normal mammalian cell line (HEK). We examined whether canolol and phenylindane have a protective effect on the cells with induced oxidative stress. The results showed a cytotoxic effect of canololand phenylindane on all three cell lines, however phenylindan has a stronger cytotoxic effect. Also, phenylindane has a greater antioxidant potential than canolol. There had been no record of protective effect of canolol and phenylindane on the cells with induced oxidative stress ...
Cancertame Ayurvedic formulation contains concentrated extracts of selected anticancer herbs having antimutagenic, DNA repairing, proapoptotic, antitumourangiogenetic, immunomodulatory, chemoprotective and radioprotective properties. Cancertame Ayurvedic executes its therapeutic effect by complex synergistic interactions among phytoconstituents of these anticancer herbs.. Cancertame Ayurvedic formulation helps to fight cancer at every step (genesis, growth & spread of cancer), without side effects.. Cancertame Ayurvedic formulation promotes DNA repairing mechanism and helps to repair chromosomal abnormalities. Cancertame Ayurvedic formulation tames aggressive cancer cells by inhibiting further mutations in the genes (oncogenes & tumour suppressor genes) and pathways.. Cancertame Ayurvedic formulation reinduces the process of apoptosis (programmed cell death) in cancer cells and inhibits tumourangiogenesis (ability of cancerous growth to create new blood vessels).. Cancertame Ayurvedic ...
Chlorophyll is extracted from plants and chemically stabilized, displacing the magnesium from the core of the molecule and substituting it with copper.
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages. ...
World-leading developers of image analysis and data processing solutions for the comet assay, Ames test, automatic colony counting and many other areas of scientific research and i
Thus, tumor suppressor genes can be recognized as antimutagenic agents. TP53: This gene encodes for the p53 protein, which is ... Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the ... E. Wall, Monroe (1992). "Antimutagenic Agents from Natural Products". Journal of Natural Products. 55 (11): 1561-1568. doi: ... Mitscher, Lester A.; Telikepalli, Hanumaiah; McGhee, Eva; Shankel, Delbert M. (1996-02-19). "Natural antimutagenic agents". ...
... of the fruit showed antimutagenic and antigenotoxic properties which suggest that this fruit could work as preventive agent ... antiproliferative and antimutagenic potential of araçá-boi fruit (Eugenia stipitata Mc Vaugh - Myrtaceae) of the Brazilian ...
The antimutagenic properties of whole, fresh-water AFA were tested using the Ames test. Simultaneous addition of both algae and ... In plasma samples, the natural extract inhibited the extent of lipid oxidation induced by the pro-oxidant agent cupric chloride ... Research also characterizes the effect of a water-soluble preparation from known agents that modulate the immune system. One ... Lahitová, N.; Doupovcová, M.; Zvonár, J.; Chandoga, J.; Hocman, G. (1994). "Antimutagenic properties of fresh-water blue-green ...
Such anticaking agents have been added since at least 1911 when magnesium carbonate was first added to salt to make it flow ... and has been claimed to increase the anticlastogenic and antimutagenic properties of doenjang (a fermented bean paste). Kosher ... Edible salt is sold in forms such as sea salt and table salt which usually contains an anti-caking agent and may be iodised to ... It can be useful for brining, bread or pretzel making and as a scrubbing agent when combined with oil. Pickling salt is made of ...
Durnev AD, Zhanataev AK, Shreder OV, Seredenin SB (Jan-Feb 2009). "Antimutagenic and antiteratogenic properties of afobazole". ... "Clinical study of the selective anxiolytic agent afobazol". Eksperimental'naia i Klinicheskaia Farmakologiia. 64 (2): 15-9. ... Experiments of mice have shown antimutagenic and antiteratogenic properties. Fabomotizole has found little clinical use outside ...
Al-Shamma A, Drake S, Flynn DL, et al. (1981). „Antimicrobial agents from higher plants. Antimicrobial agents from Peganum ... Jul). „Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities". ... Jul). „Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent". ...
Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... antimutagenic and anticarcinogenic activities. Both neem seed and neem leaves are capable of killing M. nanum. The minimum ... Like many other dermatophytes, M. nanum is tolerant of the antifungal agent cycloheximide. In addition, M. nanum also exhibits ...
... protective agents MeSH D27.505.696.706.037 - antidotes MeSH D27.505.696.706.080 - antimutagenic agents MeSH D27.505.696.706.125 ... chemical warfare agents MeSH D27.720.799.037 - antidotes MeSH D27.720.799.042 - antimutagenic agents MeSH D27.720.799.047 - ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...
Likewise, Colostrinin reduced the frequency of mutation caused by two mutagenic agents, methyl methane sulfonate and mitomycin- ... It is suggested that the antimutagenic properties of Colostrinin are achieved via multiple mechanisms - by decreasing ... of defined DNA mutations in these cells as they occur naturally and when induced by various known chemical or physical agents. ...
Agents Chemother. 38 (5): 1157-60. doi:10.1128/aac.38.5.1157. PMC 188168. PMID 8067755. Aggett, P.J.; Delves, H.T.; Harries, J. ... Ionophore Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the ...
Improvements in the manufacture and production of readily soluble tanning extracts and agents. Patent specification. Johnsons ... 2009). "Antimutagenic and antioxidant activities of quebracho phenolics (Schinopsis balansae) recovered from tannery ... Quebracho tannin acts as flocculant agent to remove surfactant as sodium dodecylbenzenesulfonate in water treatment.[15] ... Other recent studies show that quebracho tannins present a strong anti-mutagenic activity.[8] The heartwood contains from 20 to ...
"Chemical agents and related occupations, Volume 100F. A review of human carcinogens" (PDF). International Agency for Research ... Bu-Abbas, A; Nunez, X; Clifford, M; Walker, R; Ioannides, C (1996). "A comparison of the antimutagenic potential of green, ... antimutagenic, antioxidative, and antimicrobial properties. Specifically, tannins accelerate blood clotting, reduce blood ... black and decaffeinated teas: contribution of flavanols to the antimutagenic effect". Mutagenesis. 11 (6): 597-603. doi:10.1093 ...
In the 1990s, bemethyl saw use as a basic medicinal agent in many of the corps of the Soviet and Russian armies, including ... Seredenin SB, Bobkov I, Durnev AD, Dubovskaia OI (July 1986). "[Mutagenic and antimutagenic properties of bemitil]". Biulleten ... and antimutagenic. Certified in Ukraine as a dietary supplement, bemethyl is commonly used in preparing for international ...
Classification of agents Archived 2010-03-12 at the Wayback Machine Posted by Flavio Guzmán on 12/08/08 Translation: Protein ... Antimutagenic DNA polymerases of bacteriophage T4. Cold Spring Harb Symp Quant Biol. 1968;33:339-44. doi: 10.1101/sqb.1968.033. ...
Antimutagenic. S. calva. NA. Chloroform. Ames Salmonella/microsome assay Convulsant. S. acmella. Whole plant. Hexane. ... Flavoring Agents: Aliphatic and Aromatic Amines and Amides". World Health Organization technical report series. 65 (947): 1-225 ... A concentrated extract of the Spilanthes plant identified as jambu is used as a flavoring agent in many countries worldwide.[11 ... an agent that promotes salivation.[21] Spilanthol is absorbed trans-dermally and through the buccal mucosa.[22][23] Spilanthol ...
I. Agents microorganisms and protistans". Dis. Aquat. Org. 2: 147-62. doi:10.3354/dao002147. Kinne O, ed. (1980). Diseases of ... Sulfate polysaccharides exhibit immunomodulatory, antitumor, antithrombotic, anticoagulant, anti-mutagenic, anti-inflammatory, ... Cyanobacteria may possess the ability to produce substances that could one day serve as anti-inflammatory agents and combat ... high cell density or exposure to DNA damaging agents. In chromosomal transformation, homologous transforming DNA can be ...
Taspine was found to be the principal cicatrizant agent in murine models as well as able to increase the chemotaxis of human ... antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex". Phytomedicine. 10 (2-3): 139-144. doi: ... to examine the role of sangre de grado from Croton lechleri as an effective antifungal agent in animal and human models. ... has led to scientific study and observation of its in vitro antioxidant activity as well as both mutagenic and antimutagenic ...
Bhaskaran, N; Shukla, S; Srivastava, JK; Gupta, S (December 2010). "Chamomile: an anti-inflammatory agent inhibits inducible ... anti-inflammatory and some antimutagenic and cholesterol-lowering effects for chamomile. As well chamomile was found to be ...
These seeds are separated from the flesh, dried for 10-15 days, and used as an acidic agent for chutney and curry preparation. ... Negi, P. S.; Jayaprakasha, G. K.; Jena, B. S. (2003). "Antioxidant and antimutagenic activities of pomegranate peel extracts". ...
Table salt is a refined salt containing about 97 to 99 percent sodium chloride.[27][28][29] Usually, anticaking agents such as ... and has been claimed to incréase the anticlastogenic and antimutagenic properties of doenjang (a fermented béan paste).[47] ... The additive is considered safe for human consumption.[38][39] Such anti-caking agents have been added since at léast 1911 when ... Sodium ferrocyanide, also known as yellow prussiate of soda, is sometimes added to salt as an anticaking agent. ...
The antimutagenic properties were assayed against the spontaneous and t-BOOH-induced mutagenesis in Escherichia coli IC202 oxyR ... antimutagenic and antibacterial properties of the essential oil (EO) of the leaves of Eucalyptus gunnii Hook. (Southern ... Many of them have been qualified as natural antioxidant and antimutagenic agents [24,25]. Hence, it was reasonable to presume ... Antimutagenic Activity. The antimutagenic effect of the E. gunnii oil against the spontaneous and t-BOOH-induced mutagenesis ...
Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from ... Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from ...
Thus, tumor suppressor genes can be recognized as antimutagenic agents. TP53: This gene encodes for the p53 protein, which is ... Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the ... E. Wall, Monroe (1992). "Antimutagenic Agents from Natural Products". Journal of Natural Products. ACS Publications. 55 (11): ... doi:10.1016/0165-7992(91)90090-q. "Natural antimutagenic agents". Mutation Research/Fundamental and Molecular Mechanisms of ...
Protective Agents. Physiological Effects of Drugs. Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. ...
Protective Agents. Physiological Effects of Drugs. Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. ...
Vasodilator Agents. Antimutagenic Agents. Protective Agents. Physiological Effects of Drugs. To Top ...
Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. Neuroprotective Agents. Antiprotozoal Agents. ... Antiparasitic Agents. Anti-Infective Agents. Chelating Agents. Sequestering Agents. Antineoplastic Agents, Phytogenic. Protease ...
Anti-Inflammatory Agents. *Anticarcinogenic Agents. *Antimutagenic Agents. *Antineoplastic Agents, Phytogenic. *Antioxidants. * ...
Natural antimutagenic agents. Mutat. Res 1996, 350, 142-143. [Google Scholar]. *Owen, RW; Giacosa, A; Hull, WE; Haubner, R; ... there are many agents with unique chemical and biochemical properties, which are linked to redox processes, metal binding and ... U937 is a well characterized cell line and the response of this cell line to various inflammatory agents has been well ... antimutagenic, anticarcinogenic, antibacterial, or antiviral activities to a greater or lesser extent [12-15]. ...
The potential antimutagenic and antioxidant effects of Maillard reaction products used as "natural antibrowning" agents. ... The aim of this study was to identify the potential antioxidative and antimutagenic effects of Maillard reaction products (MRPs ...
Anti-Infective Agents / pharmacology* * Anti-Inflammatory Agents / pharmacology* * Antimutagenic Agents / pharmacology* * ... All the samples exhibited antimutagenic activity, even though some samples were more effective in decreasing the number of gene ... Biological activities of commercial bee pollens: antimicrobial, antimutagenic, antioxidant and anti-inflammatory Food Chem ...
Pharmacological Actions : Antimutagenic Agents. Additional Keywords : Drug: Mitomycin, Plant Extracts. [+] Administration of ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 downregulation, Nitric Oxide Inhibitor, Tumor ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor ... Pubmed Data : J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):395-9. PMID: 26122228 ...
Antimutagenic Agents. 1. 2. Contraceptive Agents: Male. 1. 2. ER alpha receptor up-regulation. 1. 2. ... Pharmacological Actions : Analgesics, Anti-Allergic Agents, Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, ... Pharmacological Actions : Anti-Bacterial Agents. Additional Keywords : Anti-Bacterial Agents, Dandelion, Escherichia coli ... Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective, Tumor Necrosis Factor (TNF) Alpha ...
Pharmacological Actions : Antimutagenic Agents. [+] Echinacea may prevent and treat photodamage of the skin by UVA/UVB ... Caffeic acid phenethyl ester maybe a promising agent for the prevention of skin photoaging via targeting histone ... Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin ... Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-8 downregulation, Prostaglandin ...
Antimutagenic Agents / pharmacology* * Carcinogens / toxicity* * Dose-Response Relationship, Drug * Humans * Male * ... Antimutagenic properties of three extracts from each of the selected plants were investigated using a preincubation ... Some of these were tested for antimutagenic potential in parallel experiments to those done with the food plant extracts. ... Using the New Zealand food database, a number of nutrients and micronutrients with antimutagenic and anticarcinogenic potential ...
DNA Adducts With Chlorophyll and Chlorophyllin As Antimutagenic Agents Heidar-Ali Tajmir-Riahi, Jean-Francois Neault, Stavroula ...
0 (Antimutagenic Agents); 0 (Dextrans); 0 (Phenols); 1P9D0Z171K (Butylated Hydroxytoluene); YC9U0409D3 (Cystaphos). ... The effect of phenol derivatives on the antimutagenic activity of dextran].. [Ti] T tulo:. Vliianie proizvodnykh fenola na ... 0 (Radiation-Protective Agents); 24937-83-5 (Poly A); 27416-86-0 (Poly U); M487QF2F4V (Amifostine); X6Q56QN5QC (Hydroxyurea); ... while the increasing number of active links in the dextran molecule insignificantly enhanced its antimutagenic effect. The ...
0 (Antimutagenic Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Mutagens); 0 (Plant Extracts); 0 (Polyphenols); 0 (teucrium ... 0 (Antifungal Agents); 0 (Antimalarials); 0 (Antiprotozoal Agents); 0 (Oils, Volatile); 0 (Plant Oils). ... These results demonstrate that -eudesmol may be a novel anticancer agent for the treatment of lung and colon cancer by ... 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 059QF0KO0R (Water); 9000-07-1 (Carrageenan); 9001-32-5 (Fibrinogen); 9007-41-4 ...
Shows antimutagenic effects against a range of mutagenic agents but potentiates the mutagenic effects of alkylating agents. ... Antioxidant, antimutagenic agent. Shows antimutagenic effects against a range of mutagenic agents but potentiates the mutagenic ... effects of alkylating agents. Shows antiproliferative effects. Chlorophyll a- and b-derivative. Shows antioxidant effects in ...
Antimutagenic Agents / pharmacology*. Male. Plant Extracts / pharmacology. Rats. Rats, Sprague-Dawley. Salmonella typhimurium ... 0/Antimutagenic Agents; 0/Plant Extracts; 0/Triterpenes; 1162-65-8/Aflatoxin B1; 77-52-1/ursolic acid ...
Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents Hans F. Stich, Miriam P. Rosin ...
Anticarcinogenic Agents (therapeutic use) *Antimutagenic Agents (therapeutic use) *Carcinoma, Hepatocellular (etiology, ... One agent, oltipraz, is a potent inducer of phase 2 enzymes involved in the detoxication of carcinogens including aflatoxin. A ... Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with ... Experimentally, aflatoxin-induced hepatocarcinogenesis can be inhibited by over a score of different chemopreventive agents ...
It acts as an antioxidant, antihyperglycemic, anti-inflammatory, antimutagenic, and antiulcer agent [2-5]. ...
... and broccoli contains potent anti-mutagenic agents.* *Contains the carotenoid lutein which has been documented to help protect ...
Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents Hans F. Stich, Miriam P. Rosin ...
Isolation and identification of higher plant agents active in antimutagenic assay systems: Glycyrrhiza glabra. In: Shankel, D.M ... glabra have been consumed for the past 6000 years and are used as flavoring and sweating agents, demulcents, and expectorants ... in the Western world and as antiallergic and anti-inflammatory agents in Japan and China (Chandler, 1985; Mitschner et al., ...
Yoo, Y.S. (1986) Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs. J. Osaka City Med. Center, 34(3 ... The metabolism of the hydrolysis products is discussed in the introduction to this chapter on flavouring agents. 1.4 ... their use as flavouring agents. 1.3 Absorption, metabolism and elimination It is expected that the esters in this group will be ... flavouring agents 1.5 Consideration of combined intakes 1.6 Conclusions 2. Relevant background information 2.1 Explanation 2.2 ...
Yoo, Y.S. (1986) Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs . J. Osaka City Med. Center, 34( ... Although the etiological agent was not isolated, Klebsiella pneumoniae was isolated from similarly affected mice at this ... 1.2 Estimated daily per capita intake The total annual production volume of the 26 terpenoid esters used as flavouring agents ... Agents Step 1. All of the 26 terpenoid esters are in class I. Step 2. It is expected that the esters in this group will be ...

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