Antimutagenic Agents: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Micronutrients: Essential dietary elements or organic compounds that are required in only small quantities for normal physiologic processes to occur.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Carotenoids: The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)Tea: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.Camellia sinensis: Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Cognition: Intellectual or mental process whereby an organism obtains knowledge.Polyphenols: A large class of organic compounds having more than one PHENOL group.Brain Concussion: A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)Theft: Unlawful act of taking property.Karyometry: Microscopic study of the spacial distribution pattern of CHROMATIN in CELL NUCLEI and CELL NUCLEOLI.Cervical Intraepithelial Neoplasia: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Human papillomavirus 16: A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Colposcopy: The examination, therapy or surgery of the cervix and vagina by means of a specially designed endoscope introduced vaginally.Amino Acids, SulfurSulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Decarboxylation: The removal of a carboxyl group, usually in the form of carbon dioxide, from a chemical compound.Spermidine Synthase: An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to putrescine in the biosynthesis of spermidine. The enzyme has a molecular weight of approximately 73,000 kDa and is composed of two subunits of equal size.Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.Reactive Nitrogen Species: Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Adenosylmethionine Decarboxylase: An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.PicratesEriobotrya: A plant genus of the family ROSACEAE that is the source of an edible fruit. Members contain TRITERPENES.Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.Aflatoxins: Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.TriterpenesSalmonella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Aflatoxin M1: A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Embryoid Bodies: Spontaneous aggregations of human embryonic stem cells that occur in vitro after culturing in a medium that lacks LEUKEMIC INHIBITORY FACTOR. The embryoid bodies can further differentiate into cells that represent different lineages.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.HumanitiesSocial Sciences: Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.PeriodicalsBrazilDatabases, Bibliographic: Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.Periodical IndexBibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.French Guiana: A French overseas department on the northeast coast of South America. Its capital is Cayenne. It was first settled by the French in 1604. Early development was hindered because of the presence of a penal colony. The name of the country and the capital are variants of Guyana, possibly from the native Indian Guarani guai (born) + ana (kin), implying a united and interrelated race of people. (From Webster's New Geographical Dictionary, 1988, p418 & Room, Brewer's Dictionary of Names, 1992, p195)Metals, Light: Metals with low specific gravity, typically smaller than 5, characterized by a single valence (1, 2, or 3), a simple spectrum, strong electromotive force (positive), and colorless compounds. (From Grant & Hackh's Chemical Dictionary, 5th ed)Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.Common Cold: A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.Garlic: One of the Liliaceae used as a spice (SPICES) and traditional remedy. It contains alliin lyase and alliin, which is converted by alliin lyase to allicin, the pungent ingredient responsible for the aroma of fresh cut garlic.Allium: A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.Mucus: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.Lupinus: A plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Qi: The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)

Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. (1/241)

Epigallocatechin gallate (EGCG) is a major water-soluble component of green tea. The antimutagenic activity of EGCG against benzo[a]pyrene (B[a]P)-induced mutations was assessed by using transgenic mice carrying the rpsL gene as a monitor of mutations. Seven-week-old male mice were given drinking water containing EGCG for 3 weeks. On day 7, mice were treated with a single i.p. injection of B[a]P (500 mg/kg body wt). Two weeks after the injection, the mutations in the rpsL gene were analyzed. B[a]P treatment resulted in an approximately 4-fold increase of mutation frequency at the rpsL gene in the lung. An approximately 60% reduction in the B[a]P-induced mutations in the lung was observed when mice were given EGCG at concentrations >0.005%. B[a]P-induced mutations mainly occurred at G:C basepairs in the several specific nucleotide sequences of the rpsL gene. These were AGG, CGG, CGT, TGG, TGC and GGT: all of them contained a guanine residue. Mutations seen similarly in the human Ki-ras codon 12 or p53 codons 157, 248, and 273 of lung tumor were also found in the rpsL gene, and the mutations were suppressed by the EGCG treatment. In conclusion, the antimutagenic effects of EGCG for B[a]P-induced mutagenesis in vivo suggest that drinking green tea may reduce the tumor-initiating potency of B[a]P in the lung.  (+info)

Antimutagenicity of sweetpotato (Ipomoea batatas) roots. (2/241)

Antimutagenicity of the water extracts prepared from the storage roots of four varieties of sweetpotato with different flesh colors was investigated using Salmonella typhimurium TA 98. The extract from the whole roots of the purple-colored Ayamurasaki variety effectively decreased the reverse mutation induced not only by Trp-P-1, Trp-P-2, IQ, B[a]P, and 4-NQO but also by dimethyl sulfoxide extracts of grilled beef. Comparison of the inhibitory activity of the extracts from the normal Ayamurasaki and its anthocyanin-deficient mutant one suggested that the anthocyanin pigment in the flesh decreases the mutagenic activity of the mutagens as heterocyclic amines. Two anthocyanin pigments purified from purple-colored sweet-potato, 3-(6,6'-caffeylferulylsophoroside)-5-glucoside of cyanidin (YGM-3) and peonidin (YGM-6) effectively inhibited the reverse mutation induced by heterocyclic amines, Trp-P-1, Trp-P-2, and IQ in the presence of rat liver microsomal activation systems.  (+info)

Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues. (3/241)

The mechanisms involved in the modulation of genotoxic and related effects by carotenoids and vitamin A were inferred from a critical review of an ad hoc constructed database. Almost 500 results were generated in experimental models evaluating the activity of 32 structurally, metabolically and functionally related nutrients, including beta-carotene and 26 other carotenoids, retinol, retinal, all-trans-retinoic acid and retinyl esters. As many as 67 experimental test systems, either in vitro or in vivo, used a variety of cellular targets and/or end-points suggestive of distinctive mechanisms of action. The bulk of available data support the view that carotenoids and vitamin A do not induce genotoxic effects per se. Even in the absence of any genotoxic agent, these nutrients appeared, on the contrary, to display some mechanisms which play protective roles in tumor promotion and progression, such as inhibition of N-myc gene expression resulting in antiproliferative effects, up-regulation of cell-to-cell communication, an increase in connexin 43 gene expression, a decrease in the 'spontaneous' cell transformation frequency and induction of differentiation in vitro. A large number of studies investigated the modulation by carotenoids and vitamin A of genotoxic and related effects produced by 69 genotoxicants, including biological agents, physical agents, chemical compounds and complex mixtures. In spite of some discrepant data, the general trend was that both carotenoids and vitamin A are poorly effective in acting as nucleophiles, nor do they appear to substantially interfere with the induction or repair of DNA damage produced by direct-acting agents. In contrast vitamin A and carotenoids, irrespective of their provitamin A role, in most studies inhibited those genotoxicants which require metabolic activation to electrophilic derivatives in either bacterial or mammalian cells. Coupled with biochemical data, the distinctive patterns observed with genotoxic agents belonging to different chemical classes suggest a complex modulation of both phase I and phase II enzymes involved in the metabolism of xenobiotics. Furthermore, carotenoids and vitamin A shared other protective mechanisms, such as scavenging of genotoxic oxygen species, modulation of signal transduction pathways, inhibition of cell transformation induced by physical and chemical agents, and facilitation of intercellular communication inhibited by genotoxic compounds. Therefore, carotenoids and vitamin A appear to work via multiple mechanisms, which would support a potential protective role in cancer initiation and in the pathogenesis of other mutation-related diseases. These conclusions are consistent with the recognized cancer-preventive activity of these nutrients in certain animal models and with the evidence provided by observational epidemiological studies, which suggested cancer-protective effects at many sites as related to their dietary intake or plasma levels. However, all these lines of evidence and mechanistically based premises contrast with the unexpected outcome of recent clinical intervention trials, which raised the concern that supplemental use of beta-carotene and vitamin A may increase the risk of lung cancer amongst high risk individuals such as tobacco smokers and asbestos-exposed workers.  (+info)

Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli. (4/241)

The spectrum of mutations induced by cobalt(II) chloride (CoCl2) was examined using plasmid pUB3 DNA, which was propagated after transfection into Escherichia coli SY1032/pKY241 host cells. The vector plasmid carried an E.coli supF suppressor tRNA gene as a target for mutations. After CoCl2 treatment, 64 independent nalidixic acid-resistant, ampicillin-resistant and Lac+ (SupF-) clones were obtained and the altered sequences of the mutated supF genes were determined. Deletions and frameshifts were the predominant mutational event (61%) induced by CoCl2 and base substitutions were induced to a lesser degree (29%). Analysis of sequence alterations at all the sites of mutation revealed that: (i) 18 of 19 base substitutions and eight of 10 frameshifts occurred at G:C sites, suggesting that the formation of N7G-Co(II) adducts may be responsible for premutagenic lesions of these mutations; (ii) short sequence repeats were mostly found at the sites of deletions and frameshifts. Slippage-misalignment is also suggested to be a mechanism for the induction of mutations at these sites.  (+info)

Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. (5/241)

Benzyl isothiocyanate (BITC) is contained in cruciferous plants which are part of the human diet. Numerous reports indicate that BITC prevents chemically induced cancer in laboratory animals and it has been postulated that BITC might also be chemoprotective in humans. On the other hand, evidence is accumulating that this compound is a potent genotoxin in mammalian cells by itself. To further elucidate the potential hazards of BITC, we investigated its genotoxic effects in different in vitro genotoxicity tests and in animal models. In in vitro experiments [differential DNA repair assay with Escherichia coli, micronucleus assay with human HepG2 cells and single cell gel electrophoresis (SCGE) assay with hepatocytes and gastrointestinal tract cells] pronounced dose-dependent genotoxic effects were found at low dose levels (+info)

Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. (6/241)

Centchroman (CC), a non-steroidal oral contraceptive and a candidate drug for breast cancer, has been reported to exhibit partial to complete remission of lesions in 40.5% of breast cancer patients. The potent anti-oestrogenic activity, negligible side-effects and anti-breast cancer activity of CC prompted us to evaluate the antimutagenic effects of this compound in a bacterial mutagenicity assay and CHO/HPRT and AS52/GPT mutation assays in vitro and in vivo in female Swiss albino mice as measured by both sister chromatid exchange (SCE) and chromosome aberrations (CA) against three known positive mutagen compounds, dimethylbenz[a]anthracene (DMBA), cyclophosphamide (CP) and mitomycin C (MMC). Antimutagenicity assays in Salmonella strains TA97a, TA100, TA98 and TA102 were carried out against commonly used known positive mutagens, sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significantly reduced number of bacterial histidine revertant colonies was observed in the plates treated with 0.1, 1, 5 and 10 microg/plate CC and a positive compound when compared with bacterial plates treated with the respective positive compound alone. Ethyl methanesulfonate (EMS), a commonly used positive mutagen for CHO/HPRT and AS52/GPT gene mutation assays, was used for antimutagenicity assay in these cells. CC exhibited protective effects against the mutagenicity of EMS in these two mammalian cell mutation assays, CHO/HPRT and AS52/GPT. In the in vivo studies, pretreatment with CC reduced DMBA-induced SCE and CA and CP- and MMC-induced CA when compared with the group treated only with the positive compounds. These results indicate that CC can reduce the mutagenic effects of known genotoxic compounds.  (+info)

Simple chemicals can induce maturation and apoptosis of dendritic cells. (7/241)

As is well known in the case of Langerhans cells, dendritic cells (DCs) play a crucial role in the initiation of immunity to simple chemicals such as noted in the contact hypersensitivity. Because DCs are scattered in non-lymphoid organs as immature cells, they must be activated to initiate primary antigen-specific immune reactions. Therefore, we hypothesized that some simple chemicals must affect the function of DCs. In this paper, we first demonstrated that human monocyte-derived DCs responded to such simple chemicals as 2, 4-dinitrochlorobenzene (DNCB), 2,4,6-trinitrochlorobenzene (TNCB), 2, 4-dinitrofluorobenzene (DNFB), NiCl2, MnCl2, CoCl2, SnCl2, and CdSO4 by augmenting their expression of CD86 or human leucocyte antigen-DR (HLA-DR), down-regulating c-Fms expression or increasing their production of tumour necrosis factor-alpha (TNF-alpha). In addition, the DCs stimulated with the chemicals demonstrated increased allogeneic T-cell stimulatory function. Next, we found that, among these chemicals, only NiCl2 and CoCl2 induced apoptosis in them. Finally, we examined the effects of these chemicals on CD86 expression by three different macrophage subsets and DCs induced from the cultures of human peripheral blood monocytes in the presence of macrophage colony-stimulating factor (M-CSF), M-CSF + interleukin-4 (IL-4), granulocyte-macrophage colony-stimulating factor (GM-CSF), and GM-CSF + IL-4, respectively. Among them, only DCs dramatically augmented their expression of CD86. These observations have revealed unique characteristics of DCs, which convert chemical stimuli to augmentation of their antigen presenting function, although their responses to different chemicals were not necessarily uniform in the phenotypic changes, cytokine production or in the induction of apoptosis.  (+info)

Modification of mutagenic activities of pro-mutagens by glyco-ursodeoxycholic acid in the Ames assay. (8/241)

Mutagenicity, co-mutagenicity and anti-mutagenicity of glycoursodeoxycholic acid (GUDCA) were examined by the Ames assay using Salmonella typhimurium strain TA98 with S9. As pro-mutagens, 2-aminoanthracene (2AA), Benzo[a]pyrene (BaP), 3-amino-1-dimethyl-5H-pyrido[4, 3-b]indole (Trp-P-2), 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) and 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline (MeIQ) were used. In addition to these pro-mutagens, blue-chitin extracts of human gallbladder bile (BCE) collected from the cholecystectomized patients with cholelithiasis were used in order to investigate the role of GUDCA on mutagen(s) actually existing in human bile. It was found that GUDCA did not show mutagenicity in this test system. Concerning the modification of mutagenic activities of pro-mutagens, GUDCA showed the different directions. GUDCA acted as co-mutagen, since it enhanced the mutagenic activities of 2AA and BaP. But, acted as anti-mutagen, since it suppressed the activities of Trp-P-2, IQ and MeIQ, all of which were classified as heterocyclic amines. GUDCA also suppressed the mutagen(s) in human bile. Because of the use of blue-chitin absorbed method for testing bile mutagenicity, the chemicals involved were considered to be heterocyclic amines and other polycyclic compounds. In these we suspect the bile mutagens are heterocyclic amines. Further examination should be directed towards the investigation into the mechanism of anti-mutagenic effects of GUDCA on mutagen(s) actually existing in human bile.  (+info)

*Antimutagen

Thus, tumor suppressor genes can be recognized as antimutagenic agents. TP53: This gene encodes for the p53 protein, which is ... Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the ... E. Wall, Monroe (1992). "Antimutagenic Agents from Natural Products". Journal of Natural Products. ACS Publications. 55 (11): ... doi:10.1016/0165-7992(91)90090-q. "Natural antimutagenic agents". Mutation Research/Fundamental and Molecular Mechanisms of ...

*Eugenia stipitata

... of the fruit showed antimutagenic and antigenotoxic properties which suggest that this fruit could work as preventive agent ... antiproliferative and antimutagenic potential of araçá-boi fruit (Eugenia stipitata Mc Vaugh - Myrtaceae) of the Brazilian ...

*List of MeSH codes (D16)

... protective agents MeSH D27.505.696.706.037 --- antidotes MeSH D27.505.696.706.080 --- antimutagenic agents MeSH D27.505.696.706 ... chemical warfare agents MeSH D27.720.799.037 --- antidotes MeSH D27.720.799.042 --- antimutagenic agents MeSH D27.720.799.047 ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ...

*Aphanizomenon flos-aquae (dietary supplement)

The antimutagenic properties of whole, fresh-water AFA were tested using the Ames test. Simultaneous addition of both algae and ... In plasma samples, the natural extract inhibited the extent of lipid oxidation induced by the pro-oxidant agent cupric chloride ... Research also characterizes the effect of a water-soluble preparation from known agents that modulate the immune system. One ... Lahitová, N.; Doupovcová, M.; Zvonár, J.; Chandoga, J.; Hocman, G. (1994). "Antimutagenic properties of fresh-water blue-green ...

*Tangeretin

... also shows enormous potential as an anti cancer agent. In in vitro studies, tangeretin appears to counteract some of ... In summary, in vitro studies show antimutagenic, antiinvasive and antiproliferative effects. One caveat is that tangeretin ... animal research shows the potential of tangeretin as a cholesterol lowering agent. A study on rats demonstrated potential ...

*Peganum harmala

1981). "Antimicrobial agents from higher plants. Antimicrobial agents from Peganum harmala seeds". J. Nat. Prod. 44 (6): 745-7 ... Peganum harmala has antioxidant and antimutagenic properties. Both the plant and the extract harmine exhibit cytotoxicity with ... Peganum harmala has been used as an emmenagogue and abortifacient agent. The "root is applied to kill lice" and when burned, ... "Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent". Phytochemistry. 66 ...

*Fabomotizole

Durnev AD, Zhanataev AK, Shreder OV, Seredenin SB (Jan-Feb 2009). "Antimutagenic and antiteratogenic properties of afobazole". ... "Clinical study of the selective anxiolytic agent afobazol". Eksperimental'naia i klinicheskaia farmakologiia. 64 (2): 15-9. ... Experiments of mice have shown antimutagenic and antiteratogenic properties. Fabomotizole has found little clinical use outside ...

*Microsporum nanum

Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... antimutagenic and anticarcinogenic activities. Both neem seed and neem leaves are capable of killing M. nanum. The minimum ... Like many other dermatophytes, M. nanum is tolerant of the antifungal agent cycloheximide. In addition, M. nanum also exhibits ...

*Colostrinin

Likewise, Colostrinin reduced the frequency of mutation caused by two mutagenic agents, methyl methane sulfonate and mitomycin- ... It is suggested that the antimutagenic properties of Colostrinin are achieved via multiple mechanisms - by decreasing ... of defined DNA mutations in these cells as they occur naturally and when induced by various known chemical or physical agents. ...

*Diiodohydroxyquinoline

Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common ... Agents Chemother. 38 (5): 1157-60. doi:10.1128/aac.38.5.1157. PMC 188168 . PMID 8067755. ...

*Quebracho tree

Other recent studies show that quebracho tannins present a strong anti-mutagenic activity. The heartwood contains from 20 to 30 ... Quebracho on factopia.com Improvements in the manufacture and production of readily soluble tanning extracts and agents. Patent ... 2009). "Antimutagenic and antioxidant activities of quebracho phenolics (Schinopsis balansae) recovered from tannery ... Quebracho tannin acts as flocculant agent to remove surfactant as sodium dodecylbenzenesulfonate in water treatment. Condensed ...

*Decaffeination

These agents help speed up the process and minimize the "washed-out" effects that water alone might have on the taste of ... Bu-Abbas, A; Nunez, X; Clifford, M; Walker, R; Ioannides, C (1996). "A comparison of the antimutagenic potential of green, ... "Chemical agents and related occupations, Volume 100F. A review of human carcinogens" (PDF). International Agency for Research ... Although it is mildly toxic and carcinogenic, its use as a decaffeination agent is allowed by the US Food and Drug ...

*Matricaria chamomilla

Bhaskaran, N; Shukla, S; Srivastava, JK; Gupta, S (December 2010). "Chamomile: an anti-inflammatory agent inhibits inducible ... Research with animals suggests antispasmodic, anxiolytic, anti-inflammatory and some antimutagenic and cholesterol-lowering ...

*Cyanobacteria

I. Agents microorganisms and protistans" (PDF). Dis. Aquat. Org. 2: 147-162. doi:10.3354/dao002147. Kinne O (ed.). Diseases of ... Sulfate polysaccharides exhibit immunomodulatory, antitumor, antithrombotic, anticoagulant, anti-mutagenic, anti-inflammatory, ... Cyanobacteria may possess the ability to produce substances that could one day serve as anti-inflammatory agents and combat ...

*Salt

Such anti-caking agents have been added since at least 1911 when magnesium carbonate was first added to salt to make it flow ... and has been claimed to increase the anticlastogenic and antimutagenic properties of doenjang (a fermented bean paste). Kosher ... Edible salt is sold in forms such as sea salt and table salt which usually contains an anti-caking agent and may be iodised to ... Usually, anticaking agents such as sodium aluminosilicate or magnesium carbonate are added to make it free-flowing. Iodized ...

*Pomegranate

These seeds are separated from the flesh, dried for 10-15 days, and used as an acidic agent for chutney and curry preparation. ... Negi, P. S.; Jayaprakasha, G. K.; Jena, B. S. (2003). "Antioxidant and antimutagenic activities of pomegranate peel extracts". ...
24 A study investigated anti-mutagenic. activity of H. antidysenterica, where methanolic bark extract of the plant demonstrated anti-mutagenic potency in sodium azide and methyl methane sulphonate induced mutagenicity in Salmonella typhimurium strains. 25 Plants with anti-hypertensive activity are investigated on their ability to inhibit the secretion of angiotensin, which causes vasoconstriction leading to increased blood pressure. Ethanolic seed extracts showed a satisfactory 24% angiotensin-converting enzyme (ACE) inhibition.26 Bark extracts tested for in vitro and in vivo anti-malarial Luminespib in vivo activity against Plasmodium falciparum isolates and P. berghei infected Swiss mice respectively, showed significant results. 27 Chloroform bark extract demonstrated the greatest anti-plasmodial activity, with an average IC50 value of 5.7 μg/ml in the in vitro experiment and 70% suppression of parasitaemia in the in vivo experiment when administered at 30 mg/kg. 27 Most of the known chemical ...
β-glucan is an important polysaccharide due to its medicinal properties of stimulating the immune system and preventing chronic diseases such as cancer. The aim of the present study was to determine the anticlastogenic effect of β-glucan in cells e
In this report, the isorhamnetin 3-o-robinobioside and its original extract, the ethyl acetate extract, from Nitraria retusa leaves, were evaluated for their ability to induce antioxidant and antigenotoxic effects in human chronic myelogenous leukemi
Antimutagens are the agents that interfere with the mutagenicity of a substance. The interference can be in the form of prevention of the transformation of a mutagenic compound into mutagen[clarification needed], inactivation, or otherwise the prevention of Mutagen-DNA reaction. Antimutagens can be classified into: Desmutagens, that inactivate the chemical interactions before the mutagen attacks the genes and Bio-antimutagens, that stop the mutation process once after the genes are damaged by mutagens. There are a number of naturally occurring anti-mutagens that show their efficient action. Nutrients such as vitamins and minerals are examples of micronutrients that are necessary for the proper maintenance of metabolism homeostasis in humans and other species. Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the examples below): Carotenoids: Induction of single break DNA repair by a rejoining mechanism and elimination of ...
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RSKK 02029. The MIC was evaluated on plant extracts as antimicrobial activity. All of bacterial strains showed the lowest sensitivity to methanol extract of E. angustifolia (3.5 mg/mL), except Yersinia enterocolitica NCTC 11174. In addition, the plant extracts were tested against the stable DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free-radical. Finally, the methanol extract displayed a strong antioxidant activity (Trolox equivalent = 1.49 mM). Also, E. angustifolia methanol extracts were screened for their antimutagenic activity against sodium azide by Ames test in absence of rat microsomal liver enzyme (-S9). The results showed that E. angustifolia methanol extracts can inhibit mutagenic agents of sodium azide. The plant leaf extracts with the inhibition of 36% sodium azide showed moderate potential in decreasing mutagenic agents in Salmonella typhimurium ...
Folinic acid (FA), clinically called leucovorin, has been widely used as a nutrient supplement in dietary intake and is capable of inhibiting cytotoxicity and chromosomal damage induced by chemicals. However, data on its antigenotoxic effect on radiation-induced chromosomal damage are limited. The present study was, therefore, performed to investigate the effect of FA on radiation-induced (X-rays and UV radiation) micronuclei (MN) and structural chromosomal aberrations (SCA) concurrently in V79 Chinese hamster lung cells. Exponentially growing cells were exposed to five doses of X-rays (1-12 Gy) and UV radiation (50-800 microJ x 10(2)/cm2) and post-treated with 5 or 50 micrograms FA/ml of culture medium for 16 h. The slides were analyzed for the presence of MN and SCA using standard procedures. X-ray treatment alone produced dose-related cytotoxicity. X-rays produced a clear dose-related clastogenicity as measured by percent of micronucleated binucleated cells (MNBN) (5-79%) and percent of ...
The basic cancer-related chemical and biological sciences, pathology, and epidemiology have contributed to the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and to the development of antimutagenic and antiproliferative agents as potential chemopreventive drugs. These disciplines have also provided the biochemical and histopathological bases for identifying intermediate biomarkers that can be used as surrogate end points for cancer incidence in clinical chemoprevention trials and for selecting cohorts for these trials. Particularly important as histological biomarkers of cancer are the cytonuclear morphological and densitometric changes that define intraepithelial neoplasia (IEN). IEN changes are on the causal pathway to cancer. They may serve as target lesions in Phase II chemoprevention trials and as standards against which other earlier cellular and molecular biomarkers can be evaluated. Strategies for the clinical evaluation ...
The aim of the present study was to investigate the antimutagenic effects of chrysin (CR), a flavonoid compound contained in many fruits, vegetables and honey. Earlier investigations with bacterial indicators showed that CR is one of the most potent antimutagens among the flavonoids. In the present study, we tested the compound in the Salmonella strains TA98 and TA100 in combination with benzo(a)pyrene (B(a)P) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and found pronounced protective activity over a concentration range between 10 and 100 microg/ml. The compound itself was devoid of mutagenic activity at all concentrations tested. In the micronucleus (MN) assay with human-derived HepG2 cells, a different pattern of activity was seen. CR itself caused significant induction of MN at dose levels > or =15 microg/ml; in combination experiments with B(a)P and PhIP, U-shaped dose-response curves were obtained and protection was found only in a narrow dose range (5 - 10 microg/ml). Our ...
Flavonoids are part of the healthy polyphenol family of chemicals which occur in plants. There are more than 4000 different flavonoids, mostly in fruits, vegetables and seeds. We eat about 1,000 mg. of flavonoids per day. Numerous health benefits have been discovered in flavonoids, including anticancer, anti-mutagenic (prevention of mutations), antioxidant, and antiviral properties. Flavonoids […]. View Post ...
Introduction and objective: The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. In view of the high incidence of cancer the aim of this article was to...
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Mannr ttindaskrifstofa slands var stofnu Almannagj ingv llum hinn 17. j n 1994, fimmt u ra afm li slenska l veldisins. Skrifstofan er h stofnun sem vinnur a framgangi mannr ttinda me v a stu la a ranns knum og fr slu og efla umr u um mannr ttindi slandi. ...
BioAssay record AID 683615 submitted by ChEMBL: Antimutagenic activity in human PBL assessed as inhibition of ethyl methanesulfonate-induced frequency of micronucleus per 1000 binucleated lymphocyte cells at 3.3 uM co-treated with ethyl methanesulfonate by cytokinesis blocking technique (Rvb = 4.00 +/- 0.41 micronucleus frequency/1000 binucleated lymphocyte cells).
Introduction. The relation between diet and health has been widely recognized by many people throughout the centuries. However, the relationship between diet and cancer has been pointed out only in the last decades (De Marini, 1998). As a consequence, diet in general is considered to be the largest source of mutagenic and carcinogenic substances for human beings. Various studies, including those using short-term assays, have helped to identify a great number of antimutagenic properties found in some foods such as: b-carotene, ascorbic acid, linoleic acid, a-tocopherol, vanillin, chlorophyllin, polyphenols and components found in black and green teas and mushrooms (Brockman et al., 1992; Lohman et al., 2001). For this reason, the finding of these substances in natural foods is extremely important not only due to their nutritional value but also as a prophylactic agent against diseases such as cancer (Ferguson, 1994).. Although various mushrooms are used nowadays as a medicine or food in some ...
An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B1, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB1 and proliferation of a cancer cell line.
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The caraway plant is a biennial herb usually with a fleshy root and slender, branched stems. It has feather-like leaves divided into very narrow segments and small white flowers. The fruit, when ripe, splits into narrow, elongated carpels, which are curved, pointed at the ends and have four longitudinal ridges on the surface. The dried fruits or seeds, brown in color, are hard and sharp to touch. They have a pleasant odor, aromatic flavor, somewhat sharp taste and leave a somewhat warm feeling in the mouth. Caraways qualities were- recognized by the ancient Egyptians, Greeks and Romans. The herb was widely used in the Middle Ages. It has been used for centuries in breads and cakes, and - with baked fruit, especially roasted apples. Because caraway was said to prevent lovers from straying, it was once an essential ingredient in love potions. The seeds of caraway were prescribed for bringing bloom to the cheeks of pale-faced Young maidens. The caraway seed is native to north and central Europe ...
Synonyms for Caraway Oil in Free Thesaurus. Antonyms for Caraway Oil. 1 synonym for caraway: Carum carvi. What are synonyms for Caraway Oil?
Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress induced by cisplatin (cDDP) are modulated by a combination of the natural pigments lutein (LT) and chlorophyll b (CLb). The protective effects observed for synergism between phytochemicals have not been completely investigated. The comet assay and micronucleus test were performed and the catalase activities and glutathione (GSH) concentrations were measured in the peripheral blood, bone marrow, liver, and kidney cells of mice. The comet assay and micronucleus test results revealed that the pigments LT and CLb were not genotoxic or mutagenic and that the pigments presented antigenotoxic and antimutagenic effects in the different cell types evaluated. This protective effect is likely ...
Sodium Magnesium Chlorophyllin is a dark green powder that is easily soluble in water and slightly soluble in alcohol. Sodium Magnesium Chlorophyllin is...
The basic cancer-related chemical and biological sciences, pathology, and epidemiology have contributed to the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and to the development of antimutagenic and anti-proliferative agents as potential chemopreventive drugs. These disciplines have also provided the biochemical and histopathological bases for identifying intermediate biomarkers that can be used as surrogate end points for cancer incidence in clinical chemoprevention trials and for selecting cohorts for these trials. Particularly important as histological biomarkers of cancer are the cytonuclear morphological and densitometric changes that define intraepithelial neoplasia (IEN). IEN changes are on the causal pathway to cancer. They may serve as target lesions in Phase II chemoprevention trials and as standards against which other earlier cellular and molecular biomarkers can be evaluated. Strategies for the clinical evaluation ...
Methods: 4T1 cell line was cultured in RPMI-1640 with 10% fetal bovine serum, at 37°C in humidified CO2-incubator. The cell viabilities were examined by MTT assay. HBV was screened for its anti-mutagenic activity against sodium azide by Ames test. The results were assessed by SPSS software and one-way ANOVA considering P , 0.05 level of significant. Results: The result showed that 6 ug/ml HBV, 20 ug/ml cisplatin and 6 ug/ml HBV with 10 ug/ml cisplatin can induce an approximately 50% 4T1 cell death. 7 mg/ml HBV with the inhibition of 62.76% sodium azide showed high potential in decreasing the mutagenic agents ...
Methods: 4T1 cell line was cultured in RPMI-1640 with 10% fetal bovine serum, at 37°C in humidified CO2-incubator. The cell viabilities were examined by MTT assay. HBV was screened for its anti-mutagenic activity against sodium azide by Ames test. The results were assessed by SPSS software and one-way ANOVA considering P , 0.05 level of significant. Results: The result showed that 6 ug/ml HBV, 20 ug/ml cisplatin and 6 ug/ml HBV with 10 ug/ml cisplatin can induce an approximately 50% 4T1 cell death. 7 mg/ml HBV with the inhibition of 62.76% sodium azide showed high potential in decreasing the mutagenic agents ...
Methods: 4T1 cell line was cultured in RPMI-1640 with 10% fetal bovine serum, at 37°C in humidified CO2-incubator. The cell viabilities were examined by MTT assay. HBV was screened for its anti-mutagenic activity against sodium azide by Ames test. The results were assessed by SPSS software and one-way ANOVA considering P , 0.05 level of significant. Results: The result showed that 6 ug/ml HBV, 20 ug/ml cisplatin and 6 ug/ml HBV with 10 ug/ml cisplatin can induce an approximately 50% 4T1 cell death. 7 mg/ml HBV with the inhibition of 62.76% sodium azide showed high potential in decreasing the mutagenic agents ...
5217 Benzo(a)pyrene (B[a]P), a carcinogen, and benzo(e)pyrene (B[e]P), a co-carcinogen, are ubiquitous environmental pollutants. Here, we examined the induction, and modulation by chlorophyllin (5μM) of CYP1A1 and CYP1B1 in NHMEC strains (M98015 and M98025) exposed to either B[a]P or B[e]P (4μM). Four exposure regimens were used: T1 - B[a]P or B[e]P alone (24h); T2 - B[a]P or B[e]P together with chlorophyllin (co-treatment, 24h); T3 - chlorophyllin pretreatment (24h) followed by B[a]P or B[e]P alone (24h); and T4 - chlorophyllin pretreatment (24h) followed by chlorophyllin plus B[a]P or B[e]P co-treatment (24h). Real-time PCR (TaqMan™) was used to examine differences in CYP1A1 and CYP1B1 expression. T1 - B[a]P induced CYP1A1 35-fold in cell strain M98015 and 10-fold in cell strain M98025. B[a]P induced CYP1B1 23-fold in cell strain M98015 and 5-fold in cell strain M98025. Levels of CYP1A1 and CYP1B1 expression were unchanged in the presence of B[e]P, with the exception of a 2-fold increase ...
Shams Eldien Koko, Talib M. A., Suliman I. Suliman, Muddathir S. Alhassan and Ahmed S. Kabbashi*. ABSTRACT. Balanites aegyptiaca has been reported to be an anti-helminthic, a purgative, febrifuge, emetic and can also cure other types of ailments like skin boils, malaria, wounds, colds, syphilis, liver and spleen disorders. Various parts of this plant have their own traditional medicinal properties. The seed is used as a febrifuge, and its oil is used to treat tumors and wounds. An aqueous extract of the bark is used in Sudanese folk medicine in the treatment of jaundice. The kernel oil exhibited anticancer activity against lung, liver, and brain carcinoma cell lines. It also has anti-mutagenic activity against Fasciola gigantica-induced mutagenicity besides anthelmintic activity against hepatic worms (Schistosoma mansoni), the aqueous leaf extract and saponins isolated from its kernel cakes have antibacterial activity. The branches are used as tooth brush. The root extracts have proved to be ...
Shams Eldien Koko, Talib M. A., Fatima Elfatih, Eman M. Zain Alabdeen and Ahmed S. Kabbashi*. ABSTRACT. Balanites aegyptiaca has been reported to be an anti-helminthic, a purgative, febrifuge, emetic and can also cure other types of ailments like skin boils, malaria, wounds, colds, syphilis, liver and spleen disorders. Various parts of this plant have their own traditional medicinal properties. The seed is used as a febrifuge, and its oil is used to treat tumors and wounds. An aqueous extract of the bark is used in Sudanese folk medicine in the treatment of jaundice. The kernel oil exhibited anticancer activity against lung, liver, and brain carcinoma cell lines. It also has anti-mutagenic activity against Fasciola gigantica-induced mutagenicity besides anthelmintic activity against hepatic worms (Schistosoma mansoni), the aqueous leaf extract and saponins isolated from its kernel cakes have antibacterial activity. The branches are used as tooth brush. The root extracts have proved to be ...
1. Saleem, Mohammad, Kaur, SJ, Kweon, Mee-Hyang, Adhami, Vaqar Mustafa, Afaq, Farrukh, and Mukhtar, Hasan (2005). Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway, Carcinogenesis, 26(11), pp 1956-1964. 2. Sondhi, Nishi, Bhardwaj, Renu, Kaur, SJ, Singh, Bikram and Kumar, Neeraj (2008) Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity potential employing Allium cepa chromosomal aberration assay Plant Growth Regulators, 54, pp 217-224 : 3. Singh,Palwinder, Mittal, Anu, Kaur, SJ., Holzer, W. and Kumar, Subodh (2008) 2,3- Diaryl-5-ethylsulfanylmethyltetrahydrofurans as new class of COX-2 inhibitors and cytotoxic agents, Organic and Biomolecular Chemistry, 6:2706-2712. 4. Singh, Palwinder, Mittal, Anu, Kaur, SJ,. and Kumar, Subodh (2008) 2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of ...
Noni juice has a tremendous anti-oxidative potential which neutralize their negative effects and diseases caused by oxidative Stress.. Prevents various Cancers such as lung cancer, liver cancer and renal cancer.. Noni juice has inhibitory action on the xanthine oxidase enzymes which treats Gout and its associated problems.. Noni juice helps in alleviating pain thereby, reducing the joint destruction implicated in the painful Arthritis.. Noni juice protects Cardiovascular system reducing the LDL (bad) cholesterol levels, total cholesterol content, homocysteine and improves HDL (good) cholesterol levels in the body.. A Hepato-protective effect of Noni assists in protecting the Liver from exposures to chronic exogenous chemicals.. Noni is effectual in speeding up Wound Healing by increasing in the weight of the granulation tissues, functioning of collagen and protein content.. Noni juice possesses anti-bacterial, anti-mutagenic, anti-inflammatory, antifungal and anti-histamine properties which ...
Noni juice has a tremendous anti-oxidative potential which neutralize their negative effects and diseases caused by oxidative Stress.. Prevents various Cancers such as lung cancer, liver cancer and renal cancer.. Noni juice has inhibitory action on the xanthine oxidase enzymes which treats Gout and its associated problems.. Noni juice helps in alleviating pain thereby, reducing the joint destruction implicated in the painful Arthritis.. Noni juice protects Cardiovascular system reducing the LDL (bad) cholesterol levels, total cholesterol content, homocysteine and improves HDL (good) cholesterol levels in the body.. A Hepato-protective effect of Noni assists in protecting the Liver from exposures to chronic exogenous chemicals.. Noni is effectual in speeding up Wound Healing by increasing in the weight of the granulation tissues, functioning of collagen and protein content.. Noni juice possesses anti-bacterial, anti-mutagenic, anti-inflammatory, antifungal and anti-histamine properties which ...
Methods: In a prospective controlled randomized trial, 18 patients with GBM underwent standard treatment with surgery, chemotherapy, and radiotherapy; nine received an additional 150-mg dose of chloroquine daily starting 1 day after surgery and continued through the observation period. Nine matched patients were included as controls. Neuroimaging studies and clinical response were periodically compared. The follow-up period ranged from 24 to 50 months. Survival time was defined as the main outcome measure. ...
Fresh lemon grass fields in Israel become Mecca for cancer patients by Allison Kaplan Sommer - April 02, 2006 A drink with as little as one gram of lemon grass contains enough citral to prompt cancer cells to commit suicide in the test tube. Israeli researchers find way to make cancer cells self-destruct - Ben…
... specifications & features from suppliers/manufacturer Organic Lemon Grass. without herbicide Fine cut 0,4-2mm. Packaging: 20-25kg in bags Or carton . parameters for heavy metals :Copper 3.3 mg/kgCadmium 0.05 mg/kgLead 0.2 mg/kgMercury not detected
100% Pure Caraway Oil,US $ 42 - 45 / Kilogram, OEM/ODM, CE, GMP, MSDS, Pure Essential Oil.Source from SNN NATURAL PRODUCTS on Alibaba.com.
... - BellaOnline Nutrition Database - BellaOnline is committed to helping our visitors become healthy and happy. Our BellaOnline Nutrition Database will help you choose the healthiest foods for your chosen lifestyle.
The common Caraway is a herb of the umbelliferous order found growing on many waste places in England, though not a true native of Great Britain. Its well-known aromatic seeds should be always at hand in the cupboard of every British housewife.
Find patient medical information for CARAWAY on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.
Turmeric is so powerful because of the wealth of beneficial compounds that are present within it. It has antibacterial, anticarcinogenic, antioxidant, antimutagenic, antifungal, antiviral, and anti-inflammatory properties. It is rich in many healthy nutrients such as iron, dietary fiber, niacin, magnesium, Vitamin C, Vitamin E, Vitamin K, potassium, protein, calcium, copper, and zinc.. Prevents ...
Analgesic FT63(3):195 ; Antialzheimeran JNP61:1212 ; Antiarthritic PM57:A56 ; Anticancer JNP61:1212 ; Anticancer (Colon) JNP61:1212 ; Anticariogenic LAF ; Anticholestatic 28-100 mg/kg orl PR6:74 ; Anticomplement IC100 0.1 mM/l gpg HH2 IC80-90 0.05 mM/l gpg HH2 ; Antidiabetic CCO ; AntiEBV CAN ; Antiedemic; Antifibrosarcomic IC80=10 uM BO2 ; Antihepatotoxic 5-20 mg/kg ipr PR6:74 ; Antihistaminic CPB39:3276 ; AntiHIV EC50=2.0 ug/ml JNP61:1090 IC50=6.5 ug/ml JNP61:1090 IC85=18 ug/ml JNP59:643 ; Antihyperlipidemic JE49:57 ; Antiinflammatory 1/3 indomethacin IC24=500 mg/kg; Antileishmanic ED50=20 uM POP:113 ; Antileukemic JNP53(3):513 ; Antilymphomic CAN ; Antimalarial IC50=28-37 ug/ml PR13:115 ; Antimetastatic IC80=10 uM BO2 ; Antimutagenic PPB17:990 ; Antiobesity? IJO16:4 ; Antioxidant BCI28:735 ; Antiplasmodial IC50=28-37 ug/ml PR13:115 ; Antiproliferative IC50=15-20 uM FT66(4):369 ; Antistaphylococcic CAN ; Antitumor CR54:701 ; Antitumor (Breast) 0.5% diet CLE104:43 IC50=15-20 uM FT66(4):369 ; ...
Analgesic FT63(3):195 ; Antialzheimeran JNP61:1212 ; Antiarthritic PM57:A56 ; Anticancer JNP61:1212 ; Anticancer (Colon) JNP61:1212 ; Anticariogenic LAF ; Anticholestatic 28-100 mg/kg orl PR6:74 ; Anticomplement IC100 0.1 mM/l gpg HH2 IC80-90 0.05 mM/l gpg HH2 ; Antidiabetic CCO ; AntiEBV CAN ; Antiedemic; Antifibrosarcomic IC80=10 uM BO2 ; Antihepatotoxic 5-20 mg/kg ipr PR6:74 ; Antihistaminic CPB39:3276 ; AntiHIV EC50=2.0 ug/ml JNP61:1090 IC50=6.5 ug/ml JNP61:1090 IC85=18 ug/ml JNP59:643 ; Antihyperlipidemic JE49:57 ; Antiinflammatory 1/3 indomethacin IC24=500 mg/kg; Antileishmanic ED50=20 uM POP:113 ; Antileukemic JNP53(3):513 ; Antilymphomic CAN ; Antimalarial IC50=28-37 ug/ml PR13:115 ; Antimetastatic IC80=10 uM BO2 ; Antimutagenic PPB17:990 ; Antiobesity? IJO16:4 ; Antioxidant BCI28:735 ; Antiplasmodial IC50=28-37 ug/ml PR13:115 ; Antiproliferative IC50=15-20 uM FT66(4):369 ; Antistaphylococcic CAN ; Antitumor CR54:701 ; Antitumor (Breast) 0.5% diet CLE104:43 IC50=15-20 uM FT66(4):369 ; ...
Lemongrass has many health benefits and healing properties. It is used to treat gastro-intestinal problems stomachaches, diarrhea, gas, bowel spasms
In the study of the suppressive compounds of methanol extract re-extracted against furylfuramide in the dichloromethane fraction isolated by SiO(2) column chromatography and identified as 7,4′-di-O-methyleriodictyol (1), 7, 3′,4′-tri-O-methyleriodictyol (2), and 3,7,4′-tri-O-methylkaempferol (3) and three flavonoids, ombuine (4), pachypodol (5), and kumatakenin (6), isolated and identified from the dichrolomethane fraction, showed that these compounds were assayed with activated Trp-P-1, and the suppressed effects of these compounds were further decreased when compared to Trp-P-1. The antimutagenic activities of these compounds against furylfuramide, Trp-P-1, and activated Trp-P-1 were assayed by the Ames test using S. typhimurium TA100, according to "Antimutagenic activity of flavonoids from Pogostemon cablin" by Miyazawa M, Okuno Y, Nakamura S, Kosaka H.(6 ...
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Cymbopogon citratus (DC) Stapf is consumed as a popular decoction owing to its nice flavor and hypotensor property. Its aqueous extract radioprotector and antimutagenic properties have been experimentally demonstrated. In addition, its DNA protective activity against UV light has been proved in plasmid DNA and bacterial models. The fractioning process is important in order to identify phytocompounds responsible for this activity. In this work, the toxicity of three fractions obtained from Cymbopogon citratus (essential oils, butanolic and aqueous fractions) were tested using the SOS Chromotest in Escherichia coli. Cymbopogon citratus chemical fractions possess cytotoxic properties in E. coli in the following order butanolic | aqueous | essentials oils. Genotoxic properties were detected in any of the fractions.
0071]Antony, J. I. X. and M. L. Shankaranarayana, 2001. The World of Food Ingredients. April/May 64-67. [0072]Bewley, J. D.; Black, M. Structure of seeds and their food reserves. In Physiology and Biochemistry of Seeds in Relation to Germination, Vol. 1 Development, Germination and Growth; Spinger-Verlag: Berlin, 1978; Chapter 2, pp 7-37. [0073]Dollear, F. G., G. E. Man, L. P. Codifer, H. K. Gardner, S. P. Koltun, and H. L. E. Vix. 1968. Elimination of aflatoxins from peanut meal. J. Am. Oil Chem. Soc. 45: 862-865. [0074]Dwarakanath, C. T., E. T. Rayner, G. E. Man, and F. G. Dollear. 1968. Reduction of aflatoxin levels in cottonseed and peanut meals by ozonization. J. Am. Oil Chem. Soc. 45: 93-95. [0075]Food and Agricultural Organization (FAO), 1998. World corn production. FAOSt database, Food and Agricultural Organization, Rome, Italy. [0076]Gonzalez de Mejia, E., M. Ramos-Gomez, G. Loarca-Pina, 1997. Antimutagenic activity of natural xanthophylls against Aflatoxin B1 in Salmonella typhimurium. ...
Claws claw has been used in folk medicine in South-American history for treatment of cancers, arthritis, gastritis and epidemic diseases. In previous article, Cats claw has exerted its anti breast caner activity in MT-3 cell lines as well as some other forms of cancers, but in other study of some extracts and their chromatographic fractions from Cats claw, researcher found that beside possessed antimutagenic activity, the extracts and fractions also consisted a direct antiproliferative activity on MCF7 cell line, with about 90% of inhibition at a concentration of 100 mg/ml ...
A panel of NHMEC strains (n=10), each derived from a different donor, was developed from tissue discarded at reduction mammoplasty (Cooperative Human Tissue Network, sponsored by the NCI and the National Disease Research Interchange) and used to study gene expression and DNA adduct formation following exposure to BP (4 M) in the presence or absence of chlorophyllin (5 M). Chlorophyllin treatment h
Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental carcinogen, has been isolated from urban air samples, tobacco smoke, and coal smoke condensate. A study was conducted to evaluate the complex interrelationships among dietary DBP doses with co-exposure to a range of CHL doses. In order to achieve adequate statistical power in the generation of multiple dose-response curves, this dose-dose matrix experiment utilized over 12,000 rainbow trout. The resulting DNA adducts were assessed and evaluated as biomarkers of exposure to discern their relationship with the final tumor outcome. CHL was highly effective in reducing DBP-initiated DNA adduct formation in the liver and stomach and strongly inhibited ...
Pain au Levain - Rye with Cracked Rye Soaker and Caraway SeedsThis formula produces an excellent rye bread that tastes great and is good plain ortoasted. With cracked rye soaker and caraway seedsincorporated into the final dough mix, toasting this bread brings out a pleasantand more pronounced rye and caraway taste. The soaker and caraway seeds gives it a good texture and a distinct ryetaste. This is a medium rye,high-hydration dough that produces a rustic type bread with open crumb and nicecolor and crust.Yield: 8 lbs 15 1/4 oz of dough or 4.08 kilograms (4 loaves @ 1kilogram (2.2 lbs) each, or 2 loaves @ 2 kilograms (4.4 lbs) each. This recipe may be halved to produce 2 loaves @1 kilogram (2.2 lbs) each or 1 large miche type loaf @ 2.2 kilograms (4.2 lbs).Time:Ferment: Double levain build (starting with a mature rye starter): 1st levain build 12-14 hours, 2nd levain mix 2.5 - 3 hours for a total of approx. 15 hours prior to final dough mix, depending on room temperatureSoak cracked rye:
Manufacturer and Exporter of Caraway Oil, Caraway Essential Oil, Kalonji Essential Oil, Natural Caraway Oil, Pure Caraway Oil by Indian Aroma Exports,india.
Aflatoxin B1 is a contaminant of agricultural and dairy products that can berelated to mutagenic and carcinogenic effects. In this report we explore the capacity of ?-mannan (Man) to reduce the DNA damage induced by AFB1 in mouse hepatocytes. Forthis purpose we applied the comet assay to groups of animals which were firstadministered Man (100, 400 and 700 mg/kg, respectively) and 20 min later 1.0 mg/kg ofAFB1. Liver cells were obtained at 4, 10, and 16 h after the chemical administration andexamined. The results showed no protection of the damage induced by AFB1 with thelow dose of the polysaccharide, but they did reveal antigenotoxic activity exerted by thetwo high doses. In addition, we induced a co-crystallization between both compounds,determined their fusion points and analyzed the molecules by UV spectroscopy. Theobtained data suggested the formation of a supramolecular complex between AFB1and Man ...
Check out our guide to the effects of Kratom strains here. The product quality is going to have some role in the intensity felt but most people feel its power. This is amount is typically regarded as extremely is kratom safe to drink powerful for an extract.. David Aardvark editor. Kratom Side Effects Heart Floresville this enlarged second edition contains a veritable treasure-trove of useful information. New endnotes provide fresh commentary and bring the text up-to-date.. Many people experience dream-like closed-eye visuals. Strong doses must only be used when one can devote several hours to the experience itself. This herb is extremely rare outside of its native region in Southeast Asia.. Antioxidant antiviral anti-mutagenic anti-leukemic anti inflammatory anti-diabetic. Commonly found in green tea. Kratom dosage has been a key factor for those looking for specific effects.. Leaf alkaloid content can vary from plant to plant and from strain to strain however super malay kratom review there ...
Deals, coupons, events, images, phone number, directions, and whats nearby Caraway Drug, a drug store business at 116 E Kentucky St, Caraway, AR 72419 on Fave.
In Production - Out of Stock. Lemon Grass is a tall tropical grass. It will tolerate cold but likes a sheltered position. It likes damp but well drained soil. It will not grow in freezing temperatures but will return after the last frost. It lasts for 3 - 4 years but can be separated and propagated this way. It is best to grow in a container to be moved into shelter for the winter months or put frost covers over it. This ensures that it grows into a large clump.. Comments Warnings : Lemon Grass is used for both culinary and medicinal purposes. Research is being conducted on it for more medicinal uses. It is made into a tea fresh or dried. It is also used in cooking. See link for details.. ...
Detailed nutritional values of Cheese, caraway type. Online analysis information with non-nutrients and nutrients composition facts table for item No. 01008 found in category Dairy and Egg Products. Data contents chart for nutritionists. Food details for CHEESE,CARAWAY in different kinds of quantities, amounts or measurements.
Business Directory for Cobalt Chloride Suppliers in Rajkot - Get contact details of Cobalt Chloride Manufacturers, Wholesale Cobalt Chloride Exporters, Best Cobalt Chloride Traders & Distributors Across the Rajkot.
Slukvin A.M.; Goncharova R.I.; Duburs G.J.; Uldrikis J.R.; Bisenieks E.A. Protective effects of Diludine on reproductive activity, development and cytogenetic variability of Cyprinus carpio L. Proceedings, Eighth International conference on Mechanisms of antimutagenesis and anticarcinogenesis; 4-8 October; G.Bronzetti, L.R.Ferguson, S.De Flora, Eds.; : Pisa, Italy, 2003; 131 ...
Caraway Seeds Maximize the Outcome of Forskolin. Getting Forskolin with caraway seed get or oil causes it to be even more productive. Caraway plant seeds have the capability to restrain starvation. Create a tea with caraway seeds and just take it with your Forskolin, so you will identify an outstanding higher surge in the metabolic demand. You are going to not feeling starving and may be competent at stick with your eating plan prepare. Caraway and Forskolin along with one other will get rid of the various hard to clean body fat of your respective specific body.. Right Dose Will Provide the Correct Results. Choosing the best dosage may be somewhat tricky. Plenty of reviews have been totally understand the most efficient medication dosage, however it has become observed the exact affect may differ from 1 specific to a new. Some tests happen to be performed with 100 20 or so five milligrams of 20% Forskolin for each day time, while many happen to be carried out with 250 milligrams of ten percent ...
This site provides a venue for sweetpotato scientists, practitioners, and farmers to share, discuss, and generate new knowledge. Information is also available for the general public to learn more about sweetpotato. The goal is to build a vibrant community of practice, providing easy access to technical and scientific information concerning sweetpotato. Anyone who registers can contribute to the site. Together we will work to enhance nutrition and food security for millions of people ...
Rapeseed and its oil are the source of many biologically active compounds, especially phenolic compounds that have been confirmed to have antioxidant, antimutagenic and anticancer activity. From crude oil is isolated 4-vinyl-2,6-dimethoksiphenol or canolol and from edible oil its dimer, phenylindan. In this study, we tested the biological activity of these compounds by determination of the antioxidant capacity by ORAC method and in vitro cytotoxicity in human tumor cell lines (MCF-7, HeLa) and in normal mammalian cell line (HEK). We examined whether canolol and phenylindane have a protective effect on the cells with induced oxidative stress. The results showed a cytotoxic effect of canololand phenylindane on all three cell lines, however phenylindan has a stronger cytotoxic effect. Also, phenylindane has a greater antioxidant potential than canolol. There had been no record of protective effect of canolol and phenylindane on the cells with induced oxidative stress ...
Cancertame Ayurvedic formulation contains concentrated extracts of selected anticancer herbs having antimutagenic, DNA repairing, proapoptotic, antitumourangiogenetic, immunomodulatory, chemoprotective and radioprotective properties. Cancertame Ayurvedic executes its therapeutic effect by complex synergistic interactions among phytoconstituents of these anticancer herbs.. Cancertame Ayurvedic formulation helps to fight cancer at every step (genesis, growth & spread of cancer), without side effects.. Cancertame Ayurvedic formulation promotes DNA repairing mechanism and helps to repair chromosomal abnormalities. Cancertame Ayurvedic formulation tames aggressive cancer cells by inhibiting further mutations in the genes (oncogenes & tumour suppressor genes) and pathways.. Cancertame Ayurvedic formulation reinduces the process of apoptosis (programmed cell death) in cancer cells and inhibits tumourangiogenesis (ability of cancerous growth to create new blood vessels).. Cancertame Ayurvedic ...
Chlorophyll is extracted from plants and chemically stabilized, displacing the magnesium from the core of the molecule and substituting it with copper.
Carum Carvi These seeds are a favorite addition to a number of vegetable and pasta dishes. The plant has feathery, carrot like leaves, and white flower umbels,
These tiny seeds and their oil have been used to cook and treat various ailments for centuries. Find out more about what they can do for you. Learn more at eVitamins Schweiz.
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages. ...
World-leading developers of image analysis and data processing solutions for the comet assay, Ames test, automatic colony counting and many other areas of scientific research and i
TY - JOUR. T1 - Enhancement of micronuclei frequency by vindesine in mouse bone marrow. AU - Jagetia, Ganesh Chandra. AU - Jyothi, P.. PY - 1997/1/15. Y1 - 1997/1/15. N2 - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.. AB - Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of ...
Define caraway seed bread. caraway seed bread synonyms, caraway seed bread pronunciation, caraway seed bread translation, English dictionary definition of caraway seed bread. Noun 1. caraway seed bread - bread containing caraway seeds bread, breadstuff, staff of life - food made from dough of flour or meal and usually raised with...
In recent decades, cancer is one of the generative diseases that occurs in human of all age groups. Cancer as a series of metabolic abnormalities causes illness and eventual death of the patient, so that the cancer needs special attention. Research showed that ACA (1acetoxy chavicol acetate) contained in red ginger rhizomes had a capability to inhibit growth induced by carcinogenic agent. The aim of this research was to investigate the characteristics of simplex, phytochemical screening, and antimutagenictest ethanol extract of red ginger rhizome in male mice of which induced using monosodium glutamat with dosage 5460 mg/kgBB by intraperitonial. The extraction was done by maceration using 96% ethanol. Antimutagenic test using male mice were induced monosodium glutamat dose 5460 mg/kg BB by intraperitoneal. Ethanol exctract red ginger rhizome administrated orally at doses of 200, 400, and 800 mg/kg BW. Antimutagenic activity showed by a decrease in the number of micronucleus in polychromatic ...
Sigma-Aldrich offers abstracts and full-text articles by [Yasir H Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal, Mohammad Faisal].
Incredible Curcumin!. Turmeric contains constituents called "curcuminoids" that demonstrate antioxidant, anti-mutagenic, anti-genotoxic, anti-carcinogenic and anti-inflammatory activity. The most important of these constituents is called curcumin, which makes up 3% of the total content of turmeric. Curcumin has a molecular structure similar to the plant pigments "resveratrol" found in grape seeds/skins and "catechins" found in green tea, etc. Plant polyphenols share natural anti-oxidant and anti-inflammatory properties-just another reason fruits and vegetables are so essential for great health.. Pain and Inflammation. When injured, inflammation is part of the healing process. But when it becomes chronic it is a disease. Inflammation is now understood to play a major role in the development of most diseases including pulmonary (lungs), diabetes, cancer, neurological and autoimmune diseases, cardiovascular disease, Alzheimers and the most familiar-arthritis. In most cases, degenerative diseases ...
Curcumin, a natural yellow pigment found in turmeric and the activeingredient in curry, has recently attracted considerable attentiondue to its intriguing antioxidant, antican…cer, anti-inflammatory,anti-tumor, anti-viral, anti-mutagenic, and anti-microbialcharacteristics. It is an organic compound which plays a similarrole to cholesterol in the body, it modulates the structure of thelipid bilayer. Turmeric (Curcuma Longa) family of Zingiberaceae) aPerennial herbal plant, Curcumin (Turmeric Extract) is from the roots of theturmeric plant (Extract dietary supplements rather than theturmeric) Haldi in Hindi language PasPu in Telugu language Turmeric Extract in English language (MORE) ...
Both fruit and oil possess aromatic, stimulant and carminative properties. Caraway was widely employed at one time as a carminative cordial, and was recommended in dyspepsia and symptoms attending hysteria and other disorders. It possesses some tonic property and forms a pleasant stomachic. Its former extensive employment in medicine has much decreased in recent years, and the oil and fruit are now principally employed as adjuncts to other medicines as corrective or flavouring agents, combined with purgatives. For flatulent indigestion, however, from 1 to 4 drops of the essential oil of Caraway given on a lump of sugar, or in a teaspoonful of water, will be found efficacious. Distilled Caraway water is considered a useful remedy in the flatulent colic of infants, and is an excellent vehicle for childrens medicine. When sweetened, its flavour is agreeable ...
Search Indian Crown Ethers Manufacturers and Suppliers Details - Contact to Crown Ethers Exporters in India, Crown Ethers Wholesalers, Crown Ethers Distributors and Traders from India.
Lemon Grass oil works great for treating fever, digestion, cramping, colic, and arthritis pain. Try Lemon Grass aromatherapy for Athlete s foot, headache, and circulation.
19. Hanna, I. , and Guengerich, F. P. (2001) Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Arch. Biochem. Biophys. 393, 255-261. 20. , and Guengerich, F. P. (2001) A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Res. 61, 8164-8170. 21. Omura, T. and Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. 2. 99 mL of cytochrome-c assay buffer. 3. , 1-10 µL of a 1 mg/ mL solution). Mix (see Note 29). 4. Ensure that the absorbance remains at zero for approx 1 min. 5. Add 10 µL of 5 mM NADPH only to the sample cuvet. Mix. 6. Record the change in absorbance over at least 3 min. The activity should be linear. 4 mM-1 cm-1 at 550 nm. Cytochrome P450 Systems in E. 5. Results Achieved for the Expression of P450s The results achieved for the bacterial expression of P450s in E. coli are exemplified in ...
Human Serum Albumin (HSA) is a principal extracellular protein with a high concentration in blood plasma and a carrier of many drugs to different molecular targets. Drug binding to HSA can alter the protein biophysical and biochemical properties of protein. The structural analysis of human serum albumin complexes, with naturally occurring flavonoids quercetin(antioxidant), kaempferol (antioxidant), delphinidin (antioxidant), AZT (3-azido-3-deoxythymidine) (anti-AIDS), aspirin (anti inflammatory), taxol (anticancer), cisplatin (anticancer), atrazine (herbicide), 2,4-D (herbicide), polyamines (biogenic), chlorophyll (antimutagenic), chlorophyllin (antitumor), poly(ethylene glycol) (polymer), vandyl cation and vanadate anion in aqueous solution are reported. Using capillary electrophoresis, FTIR (Fourier transform infrared), UV-Visible and CD (Circular dichroism) spectroscopic methods, the drug binding mode, the binding constant and the effects of drug complexation on protein secondary structure ...
What Are the Health Benefits of Lemon Grass and How to Use It. Lemongrass is a plant, smells like lemon, but it tastes milder and sweeter.
Both West Indian and East Indian lemon grass grow well in the Southwest because they are drought and heat tolerant. They are, however, frost sensitive and the brown ends may need to trimmed back after a cold winter. The plants do well growing in pots and can be temporarily moved indoors if necessary.. Lemon grass plants are easy to propagate. Many Asian markets sell lemon grass stalks, so look for some with the bulb and a few roots still intact. Simply stick the root/bulb part of stalk into moist soil for rooting. It is also possible to separate and move the stalks from an established clump of lemon grass.. ...
Responsive supramolecular gels were constructed from crown ether terminated four-arm star poly(ε-caprolactone) (PCL-DB24C8) and dibenzylammonium-terminated two-arm PCL-DBAS (see scheme), exploiting the formation of pseudorotaxane linkages between crown ether and ammonium moieties. The resultant supramolecular gels exhibit thermo- and pH-induced reversible gel-sol transition. ...
Incorporating a flexible crown ether into neutral discrete self-assemblies driven by metal coordination.: Driven by metal coordination, a flexible crown ether w
Caraway is used to treat digestive problems like colic, bloating, griping, heartburn and flatulence and infant colic. It also increases milk production for nursing mothers and has sedative qualities and relieves anxiety and tension...
Answers from doctors on do caraway seeds help bloating. First: Peppermint has been used effectively for a variety of digestive issues (flatus, nausea, vomiting, cramps, loose bowel movements, heartburn, indigestion & irritable bowel syndrome). Anecdotally (no scientific proof) it is reported to help with headaches, musculo-skeletal pain, dental pain, upper respiratory infections, inflammatory conditions as well as viral & bacterial infections.
Whisk the butter, oil, molasses and sugar until smooth, then beat in the eggs one at a time, until evenly mixed. Add the vanilla and caraway, mix well, then add the flours, baking powder and salt, and stir just to combine. Fold in the apples, divide the mixture between the cases, filling them almost to the top, and scatter almonds on top. Bake for 25 minutes, or until a skewer comes out clean ...
See all results for Caraway Soda Bread No Null No (sea Salt) Recipes. Find more recipes at Foodily.com - the largest recipe search site - and see the ones your friends like.
Previous research states that Selaginella doederleinii Hieron. can inhibit sarcoma and cervical cancerin mice and L cellisolated from human liver cancer (Dalimarta, 1999). In other research mentioned that Selaginella doederleiniiare cytotoxic against murinecells (Lin et al., 1994). Moreover, Selaginella doederleinii reported to have antimutagenic activityagainst salmonella induced carcinogen benzo [a] pyren (Lee & Lin, 1988). Widodo (2006) reported that the chloroform and methanol extractsS. doederleinii toxic to larvaeArtemia salina Leach with valueLC50 in the amount of 216,32 ± 39,63 µg/ml for chloroform extract and223,34 ± 19,64 µg/ml for the methanol extract. Nurwaini (2006) also reported that the chloroform extract, ethanol and ethyl acetate S. doederleinii have potential as antiradicalwith IC50 values ​​of51,24 µg/ml for the ethyl acetate extract, 95,26 µg/ml to extract ethanol and135,75 µg/ml for the chloroform extract.. ...
Sweetpotato is one of the worlds most important food crops in terms of human consumption, particularly in Sub-Saharan Africa, parts of Asia, and the Pacific Islands. First domesticated more than 5,000 years ago in Latin America, it is grown in more developing countries than any other root crop. Despite its name, sweetpotato is not related to the potato. It is a root, not a tuber, and belongs to the morning-glory family. Many parts of the plant are edible, including leaves, roots, and vines, and varieties exist with a wide range of skin and flesh color, from white to yellow-orange and deep purple.. ...
Abortifacient 52 ; Aldose-Reductase-Inhibitor IC50=10 uM; Alpha-Reductase-Inhibitor IC50=35 uM JEN147:295 ; Antiaggregant 1-10 ug/ml MED ; Antiangiogenic 150 uM PNA90:2693 ; Antiatherosclerotic JMF2:163 ; Anticancer (Breast) IC50=2.6-6.7 ug/ml DAI56(4):2001 ; Anticarcinomic (Breast) IC50=?640 uM MED ; Anticlimacteric JAD ; Antiendoccytotic 100 ug/ml MED ; Antiestrogenic OI8:274 ; Antifertility DUKE1992B ; Antihemolytic JLI ; Antiimplantation JE32:175 ; Antiinflammatory JMF2:179 ; Antiischemic MED ; Antileukemic >50 ug/ml (185 uM) IC50=0.010 ug/ml LS55:1061 ; Antileukotriene IC50=10-15 uM MED ; Antilymphomic JNP7:51 ; Antimelanomic MED ; Antimicrobial EEB26:65.1986 ; Antimitogenic IC50=12 uM PNA90:2693 ; Antimutagenic ID50=50-100 nM PCF:13 ; Antineuroblastomic JNP7:51 ; Antiosteoporotic OI8:274 ; Antioxidant PCF:64 ; Antiproliferative 5-45 uM PNA90:2693 ; Antiprostatadenomic 8-27 ug/ml MED ; Antiprostatitic IC50=35 uM JEN147:295 ; Antispasmodic IC50=34 uM PM58:314 ; Antitumor (Breast) JNP7:51 ; ...
In this lab simulation students conduct a modified Ames Test, which predicts carcinogenicity of chemicals. Students are provided with a virtual strain of Escherichia coli that is sensitive to (killed by) the antibiotic streptomycin, several virtual chemicals to test for mutagenicity, and two types of media (nutrient Agar and nutrient Agar + Streptomycin). The simulation allows students to propose a hypothesis about the types of chemicals that are likely to be mutagens and design an experiment to test their hypothesis.. ...
PHILLIPSON, CE and IOANNIDES, C (1989) METABOLIC-ACTIVATION OF POLYCYCLIC AROMATIC-HYDROCARBONS TO MUTAGENS IN THE AMES TEST BY VARIOUS ANIMAL SPECIES INCLUDING MAN ...
KW: setting me straight on details of influence of caffeine on dark repair of DNA; (recall it is antimutagen in Novick/Szilard chemostat expts.); Xeroderma; jl 8/5/00 ...
Product Name: 5H-pyridoindoleFormula: C11H8N2Weight: 168.19462SMILES: C1=CC2=C(C=C1)C3=C(C=CC=N3)N2CAS NO: 11006-34-1 Product: Chlorophyllin (sodium copper
Handmade Soap with EXELLENT healing property which contains natural mineral from sea cucumber extract. Excellent property of anti-fungal, insecticidal, antiseptic, and anti-inflammatory. Pure and natural.
Tonight we had a light dinner, well, light was only the main course because after that we are always having some cheese. Im French, i have no excuses. Since I went to France recently, I brought a few cheese and I just cant help it. Nothing better for me that ending a meal with some…
Clarifying Face Wash presents an alternate way to clean and oil-free skin. Its unique Ayurvedic ingredients help cleanse the deep clogged pores from the inner layers of the skin and remove excess oil from within without leaving it dry, stretched and unhealthy. It replenishes essential moisture and nourishes with every wash.. Key ingredients and Benefits:. Clarifying Face wash is blended with the extracts of Khus Khus, Tulsipatra & Vatchaal which not only removes excess oil but also hydrates & soothes the skin.. ...
Warm welcome to my health blog! This was introduced with an objective to educate and spread awareness among people, encouraging them to live healthier lives with longevity. Let me emphasize that our contemporary situation in individuals life are so fast moving that we tend to neglect and spare some moments for our own health. My inspiration has turned into passion in a health care that turned into a blog. The ample of support and response was tremendously changed into positive results. I dedicated this blog for all those people who are very conscious for their health and life style. Hope so, I can bring differences for healthy living the fore my viewer comments are always valuable and your continued patronage is important for me. Wish you a happy and healthy life ahead ...
Stem anatomy and the development of intraxylary phloem were investigated in six to eight years old Coccinia indica L. (Cucurbitaceae). Secondary growth in the stems was achieved by the normal cambial activity. In the innermost part of the thicker stems, xylem parenchyma and pith cells dedifferentiated into meristematic cells at several points. In some of the wider rays, ray cells dedifferentiate and produce secondary xylem and phloem with different orientations and sometimes a complete bicollateral vascular bundle. The inner cambial segments of the bicollateral vascular bundle (of primary growth) maintained radial arrangement even in the mature stems but in most places the cambia were either inactive or showed very few cell divisions. Concomitant with the obliteration and collapse of inner phloem (of bicollateral vascular bundles), parenchyma cells encircling the phloem became meristematic forming a circular sheath of internal cambia. These internal cambia produce only intraxylary secondary phloem
Crown ethers are heterocyclic chemical compounds that consist of a ring containing several ether groups. The most common crown ethers are oligomers of ethylene oxide, the repeating unit being ethyleneoxy (-CH2CH2O-). Important members of this series are the tetramer (n = 4, or four ethyleneoxy units), the pentamer (n = 5), and the hexamer (n = 6). The term "crown" refers to the resemblance between the structure of a crown ether bound to a cation, and a crown sitting on a head. The first number in the name of a crown ether refers to the number of atoms in the cycle, and the second number refers to the number of those atoms that are oxygen. Crown ethers are much broader than the oligomers of ethylene oxide; an important group is derived from catechol.. Crown ethers strongly bind certain cations, forming complexes. The oxygen atoms are well situated to coordinate with a cation located within the ring, whereas the exterior of the ring is hydrophobic (repels water and polar and ionic substances). The ...
As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results showed that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones had higher antimutagenic activities than other phytochemicals. At the highest dose tested, the MTX genetoxicity was suppressed by 34.03%∼67.12%. Of all the bioactive phytochemical combinations, the combination of grape seed proanthocyanidins and eleutherosides from Siberian ginseng as well as green tea polyphenols and eleutherosides exhibited stronger antimutagenic effects; the inhibition rate of methotrexate-induced genotoxicity separately reached 74.7 ± 6.5% and 71.8 ± 4.7%. Pretreatment of Kunming mice with phytochemical
Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice D.C.S. Lima1, C.R. Silva1, B.L. Sampaio2, J.R. de Paula2 and L. Chen-Chen1 Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brasil Corresponding author: L. Chen-Chen E-mail: [email protected] Genet. Mol. Res. 12 (3):
The use of plants as food and medicinal remedies since ancient times is partially attributed to the biological efficacy of secondary metabolites that possess antioxidant activities such as phenolic compounds, vitamins C and E, and carotenoids. Tea extracts are powerful antioxidants due to the presence of chemical compounds such as epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC). The waste materials such as the peels and pomace are a source of sugars, minerals and organic acids, dietary fibers and phenolics which have a wide range of actions which includes antioxidants, antimutagenic, cardio preventive, antibacterial and antiviral activities. In recent years, due to a incredible growth in processed food and fruit-processing industries, tones of by-products are produced. These by-products are potential sources of both antioxidant and nutraceutical components that can be explored. The pomegranate (Punica granatum L.) has been regarded as a ...
JUNQUEIRA, Adriana Pereira Freire; PERAZZO, Fabio Ferreira; SOUZA, Gustavo Henrique Bianco and MAISTRO, Edson Luis. Clastogenicity of Piper cubeba (Piperaceae) seed extract in an in vivo mammalian cell system. Genet. Mol. Biol. [online]. 2007, vol.30, n.3, pp.656-663. ISSN 1415-4757. http://dx.doi.org/10.1590/S1415-47572007000400025.. The plant Piper cubeba is widely distributed in tropical and subtropical regions and is used medically for various purposes but has not yet been evaluated for genotoxicity. We used male and female Swiss mice and Wistar rats and the comet assay and micronucleus test to investigate the mutagenic potential of a crude extract of P. cubeba seeds. The rodents were administered 0.5 g kg-1, 1.0 g kg-1 and 1.5 g kg-1 of the extract by gavage. For the Swiss mice, peripheral blood was collected 24 h after treatment for the comet assay, and at 48 and 72 h for the micronucleus test. For the Wistar rats, peripheral blood and hepatic cells were collected for the comet assay and ...

Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from...Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from...

Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from ... Plant Antimutagenic Agents. 7 Structure and Antimutagenic Properties of Cymobarbatol and 4-Isocymobarbatol, New Cymopols from ...
more infohttps://www.rti.org/publication/plant-antimutagenic-agents-7-structure-and-antimutagenic-properties-cymobarbatol-and-4

Molecules  | Free Full-Text | Essential Oil of Eucalyptus Gunnii Hook. As a Novel Source of Antioxidant, Antimutagenic and...Molecules | Free Full-Text | Essential Oil of Eucalyptus Gunnii Hook. As a Novel Source of Antioxidant, Antimutagenic and...

The antimutagenic properties were assayed against the spontaneous and t-BOOH-induced mutagenesis in Escherichia coli IC202 oxyR ... antimutagenic and antibacterial properties of the essential oil (EO) of the leaves of Eucalyptus gunnii Hook. (Southern ... Many of them have been qualified as natural antioxidant and antimutagenic agents [24,25]. Hence, it was reasonable to presume ... Antimutagenic Activity. The antimutagenic effect of the E. gunnii oil against the spontaneous and t-BOOH-induced mutagenesis ...
more infohttps://www.mdpi.com/1420-3049/19/11/19007/htm

Antimutagen - WikipediaAntimutagen - Wikipedia

Thus, tumor suppressor genes can be recognized as antimutagenic agents. TP53: This gene encodes for the p53 protein, which is ... Micronutrients are also pointed to perform a role in genome stability acting as potential antimutagenic agents (see the ... E. Wall, Monroe (1992). "Antimutagenic Agents from Natural Products". Journal of Natural Products. ACS Publications. 55 (11): ... doi:10.1016/0165-7992(91)90090-q. "Natural antimutagenic agents". Mutation Research/Fundamental and Molecular Mechanisms of ...
more infohttps://en.wikipedia.org/wiki/Antimutagen

Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. - Full Text View -...Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. - Full Text View -...

Protective Agents. Physiological Effects of Drugs. Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01394796

Green Tea Extract in Preventing Cervical Cancer in Patients With Human Papillomavirus and Low-Grade Cervical Intraepithelial...Green Tea Extract in Preventing Cervical Cancer in Patients With Human Papillomavirus and Low-Grade Cervical Intraepithelial...

Protective Agents. Physiological Effects of Drugs. Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. ...
more infohttps://clinicaltrials.gov/ct2/show/study/NCT00303823

Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans - Full Text View - ClinicalTrials.govAbsorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans - Full Text View - ClinicalTrials.gov

Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. Neuroprotective Agents. Antiprotozoal Agents. ... Antiparasitic Agents. Anti-Infective Agents. Chelating Agents. Sequestering Agents. Antineoplastic Agents, Phytogenic. Protease ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT03194620

IJMS  | Free Full-Text | Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review | HTMLIJMS | Free Full-Text | Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review | HTML

Natural antimutagenic agents. Mutat. Res 1996, 350, 142-143. [Google Scholar]. *Owen, RW; Giacosa, A; Hull, WE; Haubner, R; ... there are many agents with unique chemical and biochemical properties, which are linked to redox processes, metal binding and ... U937 is a well characterized cell line and the response of this cell line to various inflammatory agents has been well ... antimutagenic, anticarcinogenic, antibacterial, or antiviral activities to a greater or lesser extent [12-15]. ...
more infohttp://www.mdpi.com/1422-0067/12/5/3072/htm

Barberry | GreenMedInfo | Substance | Natural Medicine | AlternativeBarberry | GreenMedInfo | Substance | Natural Medicine | Alternative

Pharmacological Actions : Antimutagenic Agents. Additional Keywords : Drug: Mitomycin, Plant Extracts. [+] Administration of ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 downregulation, Nitric Oxide Inhibitor, Tumor ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor ... Pubmed Data : J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):395-9. PMID: 26122228 ...
more infohttps://www.greenmedinfo.com/substance/barberry

Dandelion  | GreenMedInfo | Substance | Natural MedicineDandelion | GreenMedInfo | Substance | Natural Medicine

Antimutagenic Agents. 1. 2. Contraceptive Agents: Male. 1. 2. ER alpha receptor up-regulation. 1. 2. ... Pharmacological Actions : Analgesics, Anti-Allergic Agents, Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, ... Pharmacological Actions : Anti-Bacterial Agents. Additional Keywords : Anti-Bacterial Agents, Dandelion, Escherichia coli ... Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective, Tumor Necrosis Factor (TNF) Alpha ...
more infohttp://www.greenmedinfo.com/substance/dandelion

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (Antimutagenic Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Mutagens); 0 (Plant Extracts); 0 (Polyphenols); 0 (teucrium ... 0 (Antifungal Agents); 0 (Antimalarials); 0 (Antiprotozoal Agents); 0 (Oils, Volatile); 0 (Plant Oils). ... These results demonstrate that -eudesmol may be a novel anticancer agent for the treatment of lung and colon cancer by ... 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 059QF0KO0R (Water); 9000-07-1 (Carrageenan); 9001-32-5 (Fibrinogen); 9007-41-4 ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=B01.650.940.800.575.912.250.583.520.948

Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system.Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system.

Antimutagenic Agents / pharmacology*. Male. Plant Extracts / pharmacology. Rats. Rats, Sprague-Dawley. Salmonella typhimurium ... 0/Antimutagenic Agents; 0/Plant Extracts; 0/Triterpenes; 1162-65-8/Aflatoxin B1; 77-52-1/ursolic acid ...
more infohttp://www.biomedsearch.com/nih/Ursolic-acid-inhibits-aflatoxin-B1/8000393.html

Photosynthesis Research Protocols | SpringerLinkPhotosynthesis Research Protocols | SpringerLink

DNA Adducts With Chlorophyll and Chlorophyllin As Antimutagenic Agents Heidar-Ali Tajmir-Riahi, Jean-Francois Neault, Stavroula ...
more infohttps://link.springer.com/book/10.1385/1592597998

Photosynthesis Research Protocols | Springer for Research & DevelopmentPhotosynthesis Research Protocols | Springer for Research & Development

DNA Adducts With Chlorophyll and Chlorophyllin As Antimutagenic Agents Heidar-Ali Tajmir-Riahi, Jean-Francois Neault, Stavroula ...
more infohttps://rd.springer.com/book/10.1385%2F1592597998

Chlorophyllin (sodium copper salt) | Read Reviews & Product Use Citations
		
		
	Chlorophyllin (sodium copper salt) | Read Reviews & Product Use Citations

Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent.. ... Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent. ... Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell ... Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, ...
more infohttps://www.selleckchem.com/products/chlorophyllin.html

Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet...Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet...

In addition, HK may be a new potential antigenotoxic ∕ antimutagenic agent from natural sources. However, the protective ... The antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect ... On the other hand, the results on the antimutagenic potential of HK showed a strong inhibitory effect against some direct and ... activity of HK is not general and varies with the type of DNA damage-inducing agent used. ...
more infohttps://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-203

Life Extension Anti Alcohol Antioxidants W/ Hepaprotection Complex 100 Cap, Life Extension, 01440Life Extension Anti Alcohol Antioxidants W/ Hepaprotection Complex 100 Cap, Life Extension, 01440

Chlorophyllin, an antimutagenic agent that protects the body from oxidative stress than can stimulate cellular mutation. ... Leucoselect® grapeseed extract, silymarin (from milk thistle), and resveratrol, three hepatoprotective agents that aid in ...
more infohttp://www.makemeheal.com/mmh/product.do?id=26801

Plus itPlus it

DBM is also a very strong antimutagenic agent that could effectively inhibit mutagenicity induced by several heterocyclic ... In the present study, we tested the potential of DBM as a chemotherapeutic or/and chempreventive agent using TRAMP-C1 cell ... In the present study, the efficacy of DBM as a chemopreventive agent for prostate tumorigenesis was tested using TRAMP mice ... Taken all these results together, our current study showed that DBM is a potent chemopreventive agent that potentially could be ...
more infohttp://cancerres.aacrjournals.org/content/69/17/7096

Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents<...Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents<...

Furthermore, both mutagenic and antimutagenic effects of MMR were detected, revealing a dual function of the MMR system in ... Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents. Mutagenesis. 2013 May;28(3):341 ... Distinct pathways for repairing mutagenic lesions induced by methylating and ethylating agents. In: Mutagenesis. 2013 ; Vol. 28 ... Furthermore, both mutagenic and antimutagenic effects of MMR were detected, revealing a dual function of the MMR system in ...
more infohttps://okayama.pure.elsevier.com/en/publications/distinct-pathways-for-repairing-mutagenic-lesions-induced-by-meth

To those with lungs mets- do any of you have trouble with coughing or getting out of breath? | Cancer Survivors NetworkTo those with lungs mets- do any of you have trouble with coughing or getting out of breath? | Cancer Survivors Network

N-acetyl-cysteine (NAC)-is an anticarcinogenic and antimutagenic agent. cimetidine and NAC for GI cancers (cites CIM - B3, too) ...
more infohttps://csn.cancer.org/node/230863

Evaluation of Purified Extracts of Leptogium PapillosumEvaluation of Purified Extracts of Leptogium Papillosum

Natural antimutagenic agents. Mutation Research 1996; 350: 142-143.. *Owen, R.W, Giacosa A, Hull W.E, Haubner R, Spiegelhalder ...
more infohttp://au.studybay.net/evaluation-of-purified-extracts-of-leptogium-papillosum/

The potential antimutagenic and antioxidant effects of Maillard reaction products used as natural antibrowning agents | BMC...The potential antimutagenic and antioxidant effects of Maillard reaction products used as "natural antibrowning" agents | BMC...

The potential antimutagenic and antioxidant effects of Maillard reaction products used as "natural antibrowning" agents. ... The aim of this study was to identify the potential antioxidative and antimutagenic effects of Maillard reaction products (MRPs ...
more infohttps://bmcpharma.biomedcentral.com/articles/10.1186/1471-2210-7-S2-A72

Somatic Embryogenesis in Guava ( Psidium guajava L.) | SpringerLinkSomatic Embryogenesis in Guava ( Psidium guajava L.) | SpringerLink

... antigenotoxic and antimutagenic agents. Seed cultivation displaying heterozygous gene pool with genetic variability in both ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-79087-9_1
  • Leucoselect® grapeseed extract, silymarin (from milk thistle), and resveratrol, three hepatoprotective agents that aid in reducing mutagenic compounds from potentially toxic xenobiotics and protecting cells from free radial-induced oxidative stress. (makemeheal.com)