Antimony Potassium Tartrate
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Information or data used to ensure the safe handling and disposal of substances in the workplace. Such information includes physical properties (i.e. melting, boiling, flashing points), as well as data on toxicity, health effects, reactivity, storage, disposal, first-aid, protective equipment, and spill-handling procedures.
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An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
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Effect of cysteine on the hepatic toxicity and antischistosomal activity of antimonyl potassium tartrate. (1/15)Cysteine produced a significant and progressive reduction in the toxicity of antimonyl potassium tartrate (APT) when the two substances were injected into mice and rabbits in ratios of APT to cysteine ranging from 1:1 to 1:3. The reduction in toxicity was highest with the 1:3 ratio. However, the combination of the two substances, especially in the ratio of 1:3, appreciably reduced the antischistosomal activity of APT both in vivo and in vitro. (+info)
Interaction of antimony tartrate with the tripeptide glutathione implication for its mode of action. (2/15)The tripeptide glutathione (gamma-L-Glu-L-Cys-Gly, GSH) is thought to play an important role in the biological processing of antimony drugs. We have studied the complexation of the antileishmanial drug potassium antimony(III) tartrate to GSH in both aqueous solution and intact red blood cells by NMR spectroscopy and electrospray ionization mass spectrometry. The deprotonated thiol group of the cysteine residue is shown to be the only binding site for Sb(III), and a complex with the stoichiometry [Sb(GS)3] is formed. The stability constant for [Sb(GS)3] was determined to be log K 25 (I = 0.1 M, 298 K) based on a competition reaction between tartrate and GSH at different pH* values. In spite of being highly thermodynamically stable, the complex is kinetically labile. The rate of exchange of GSH between its free and Sb-bound form is pH-dependent, ranging from slow exchange on the 1H-NMR timescale at low pH (2 s-1 at pH 3.2) to relatively rapid exchange at biological pH (> 440 s-1). Such facile exchange may be important in the transport of Sb(III) in various biofluids and tissues in vivo. Our spin-echo 1H-NMR data show that Sb(III) rapidly entered red blood cell walls and was complexed by intracellular glutathione. (+info)
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes. (3/15)Metals, such as arsenic or cadmium, have recently been demonstrated to interact with metabolic pathways, including phase I and phase II enzymes and the phase III efflux pump P-glycoprotein. In the present study, we investigated the effects of heavy metals and metalloids on the expression of the multidrug resistance-associated protein 2 (MRP2), a major hepatic transporter. Treatment of primary rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting. As(III) was also demonstrated to markedly up-regulate MRP2 gene expression in primary human hepatocytes. MRP2 mRNA induction occurring in As(III)-treated rat hepatocytes was fully blocked by actinomycin D, indicating that it required active gene transcription. It was associated with an activation of the c-Jun N-terminal kinase pathway and with a reduction of cellular glutathione levels. Quercetin, a flavonoid compound known to block As(III)-related induction of P-glycoprotein, was also found to prevent up-regulation of MRP2 gene expression in rat hepatocytes exposed to As(III). Such an effect was unlikely to be due to alteration of JNK pathway since quercetin failed to abolish As(III)-induced JNK phosphorylation. It may rather be linked to the increase of cellular glutathione levels by quercetin, thus limiting the depleting effects of As(III) on glutathione amounts. Finally, these results confirm that some metals strongly regulate expression of detoxifying proteins, including biliary drug transporters. (+info)
Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. (4/15)Using in vitro protein tyrosine phosphatase (PTPase) assays, we found that sodium stibogluconate, a drug used in treatment of leishmaniasis, is a potent inhibitor of PTPases Src homology PTPase1 (SHP-1), SHP-2, and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1. Sodium stibogluconate inhibited 99% of SHP-1 activity at 10 micrograms/ml, a therapeutic concentration of the drug for leishmaniasis. Similar degrees of inhibition of SHP-2 and PTP1B required 100 micrograms/ml sodium stibogluconate, demonstrating differential sensitivities of PTPases to the inhibitor. The drug appeared to target the SHP-1 domain because it showed similar in vitro inhibition of SHP-1 and a mutant protein containing the SHP-1 PTPase domain alone. Moreover, it forms a stable complex with the PTPase: in vitro inhibition of SHP-1 by the drug was not removed by a washing process effective in relieving the inhibition of SHP-1 by the reversible inhibitor suramin. The inhibition of cellular PTPases by the drug was suggested by its rapid induction of tyrosine phosphorylation of cellular proteins in Baf3 cells and its augmentation of IL-3-induced Janus family kinase 2/Stat5 tyrosine phosphorylation and proliferation of Baf3 cells. The augmentation of the opposite effects of GM-CSF and IFN-alpha on TF-1 cell growth by the drug indicated its broad activities in the signaling of various cytokines. These data represent the first evidence that sodium stibogluconate inhibits PTPases and augments cytokine responses. Our results provide novel insights into the pharmacological effects of the drug and suggest potential new therapeutic applications. (+info)
Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. (5/15)The capability of the obligate intracellular parasites like Leishmania donovani to survive within the host cell parasitophorous vacuoles as nonmotile amastigotes determines disease pathogenesis, but the mechanism of elimination of the parasites from these vacuoles are not well understood. By using the anti-leishmanial drug potassium antimony tartrate, we demonstrate that, upon drug exposure, intracellular L. donovani amastigotes undergo apoptotic death characterized by nuclear DNA fragmentation and externalization of phosphatidylserine. Changes upstream of DNA fragmentation included generation of reactive oxygen species like superoxide, nitric oxide, and hydrogen peroxide that were primarily concentrated in the parasitophorous vacuoles. In the presence of antioxidants like N-acetylcysteine or Mn(III) tetrakis(4-benzoic acid)porphyrin chloride, an inhibitor of inducible nitric-oxide synthase, a diminution of reactive oxygen species generation and improvement of amastigote survival were observed, suggesting a close link between drug-induced oxidative stress and amastigote death. Changes downstream to reactive oxygen species increase involved elevation of intracellular Ca2+ concentrations in both the parasite and the host that was preventable by antioxidants. Flufenamic acid, a non-selective cation channel blocker, decreased the elevation of Ca2+ in both the cell types and reduced amastigote death, thus establishing a central role of Ca2+ in intracellular parasite clearance. This influx of Ca2+ was preceded by a fall in the amastigote mitochondrial membrane potential. Therefore, this study projects the importance of flufenamic acid-sensitive non-selective cation channels as important modulators of antimonial efficacy and lends credence to the suggestion that, within the host cell, apoptosis is the preferred mode of death for the parasites. (+info)
Expression and regulation of the antimonite, arsenite, and arsenate resistance operon of Staphylococcus xylosus plasmid pSX267. (6/15)The arsenate, arsenite, and antimonite resistance region of the Staphylococcus xylosus plasmid pSX267 was subcloned in Staphylococcus carnosus. The sequenced DNA region revealed three consecutive open reading frames, named arsR, arsB, and arsC. Expression studies in Escherichia coli with the bacteriophage T7 RNA polymerase-promoter system yielded three polypeptides with apparent molecular weights of 8,000, 35,000, and 15,000, which very likely correspond to ArsR, ArsB, and ArsC, respectively. ArsB was distinguished by its overall hydrophobic character, suggesting a membrane association. The arsenate, arsenite, and antimonite resistance was shown to be inducible by all three heavy metal ions. Inactivation of the first gene, arsR, resulted in constitutive expression of resistance. Similar results were obtained with transcriptional fusions of various portions of the ars genes with a lipase reporter gene, indicating a function of ArsR as a negative regulator of a putative promoter in front of arsR. The inactivation of arsR also resulted in reduction of resistance to arsenite and antimonite, while arsenate resistance was unaffected. The three ars genes conferred arsenite resistance in E. coli and arsenite as well as arsenate resistance in Bacillus subtilis. (+info)
The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania. (7/15)Antimony-containing drugs are still the drugs of choice in the treatment of infections caused by the parasite Leishmania. Resistance to antimony is now common in some parts of the world, and several mechanisms of resistance have been described. By transfecting cosmid banks and selecting with potassium antimonyl tartrate (SbIII), we have isolated a cosmid associated with resistance. This cosmid contains 2 copies of the heat shock protein 70 (HSP70) and 1 copy of the heat shock cognate protein 70 (HSC70). Several data linked HSP70 to antimony response and resistance. First, several Leishmania species, both as promastigotes and amastigotes, increased the expression of their HSP70 proteins when grown in the presence of 1 or 2 times the Effect Concentration 50% of SbIII. In several mutants selected for resistance to either SbIII or to the related metal arsenite, the HSP70 proteins were found to be overexpressed. This increase was also observed in revertant cells grown for several passages in the absence of SbIII, suggesting that this increased production of HSP70 is stable. Transfection of HSP70 or HSC70 in Leishmania cells does not confer resistance directly, though these transfectants were better able to tolerate a shock with SbIII. Our results are consistent with HSP70 and HSC70 being a first line of defense against SbIII until more specific and efficient resistance mechanisms take over. (+info)
Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum. (8/15)We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed. (+info)
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ANTIMONY POTASSIUM TARTRATE HEMIHYDRATE 99 percent pure powder (Tartar Emetec Potassium Antimony Tartrate Hemihydrate)
Antimony potassium tartrate hemihydrate is also referred to as potassium antimonyl tartrate, potassium antimontarterate, and emeric tartar. It is a white crystalline powder. Antimony potassium tartrate hemihydrate is slightly soluble in water.It was used in the treatment of schistosomiasis and leishmaniasis.
Continuous Flow Hydride Generation-Fourier Transforms Infrared Spectrometric Determination of Antimony in Homeopathic ...
Abstract:. Introduction: Antimony potassium tartrate is a component of certain expectorants in homeopathic medicine, particularly in those classified as antihomotoxic remedies. Given that antihomotoxic products are prepared with different epistemological and methodological statuses, they should be tested to prevent eventual toxic effects. Methods: In this study, we evaluate the possibility of using continuous flow hydride generation (HG) coupled with Fourier transforms infrared spectroscopy (FTIR) for determining antimony concentration in antihomotoxic products containing antimony potassium tartrate. Results: The results showed good agreement with the theoretically estimated values for the liquid commercial samples, in the range from 0.5 μg/mL to 30 μg/mL, following the principle of decimal dilutions used in homeopathic medicine. Liquid samples were analyzed directly from the commercial container. Discussion: In the absence of regulatory standards for antihomotoxic products, the proposed ...
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Kaliumnatriumtartrat n. English-german technical dictionary. This is widely used for the measurement of protein and consists of two steps: the reaction of a protein with copper ions in an alkaline solution and the reduction of a Folin-Ciocalteu reagent by copper-treated protein containing tyrosine and tryptophan residues. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure There are 95 nucleotides in the 5′ noncoding region, and the single open reading frame has 10 296 nucleotides. Antimony potassium tartrate Accession Number DB15587 Description. Basic Cream of Tartar Facts . The sedimentation coefficient of the virion is approximately 200S and it sediments at a density of 1.20-1.23 g cm−3 in potassium tartrate-glycerol or sucrose gradients. In case of extremely low level of potassium (lower than 2.5 mmol/L) the following symptoms are appeared: malaise and fatigue. potassium sodium tartrate a compound used as a saline cathartic. Rochelle salt, also ...
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Potassium tartrate, dipotassium tartrate or argol has formula K2C4H4O6. It is the potassium salt of tartaric acid. It is often confused with potassium bitartrate, also known as cream of tartar. As a food additive, it shares the E number E336 with potassium bitartrate. ...
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The Rawitz method involves mordanting with tannic acid and potassium antimony tartrate, and staining with basic fuchsine. The mordanting causes basic fuchsine to act as though it were an acid dye (inversion staining).. A modification of the method is described in the present paper. This modification makes it possible to obtain the same results in a shorter time.. The chief substances stained by Rawitzs method are phospholipids, certain proteins, and certain polysaccharides.. Although the method cannot be regarded as a cytochemical test in the strict sense, yet it gives useful indications of chemical composition and in addition is valuable to the morphological cytologist as a technique for showing certain cytoplasmic inclusions (mitotic spindle, acrosome, mitochondria, Golgi apparatus of certain cells).. ...
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Heavy metal-containing solutions and solids: container E. Stir Raney nickel (also: Urushibara nickel) in the form of an aqueous suspension into hydrochloric acid (Cat. No. 100312) until dissolved (container E). Neither Raney nickel itself nor any filter residues should be allowed to dry out, otherwise they will spontaneously ignite in air. In this context, heavy metal means any compound of antimony, arsenic, cadmium, chromium(VI), copper, lead, nickel and tin, as well as these subtances in metallic form, if they are classified as hazardous (acc. to AbfallverzeichnisV - Waste Catalogue Ordinance, Appendix 3). Other heavy metals should be collected separately ...
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The virus in the EB-3 cell line derived from a Burkitt lymphoma was partially purified by digestion with proteolytic enzyme and by density-gradient centrifugation on potassium tartrate. Electron microscope studies of both sectioned and negatively stained samples suggest that the virus belongs to the herpes-virus group, although the exact number of capsomeres was not unequivocally established. ...
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A Long-Term Extension Study of AT2101 (Afegostat Tartrate) in Type 1 Gaucher Patients - Full Text View - ClinicalTrials.gov
This was an open-label, long-term extension study of afegostat tartrate in participants with type 1 Gaucher disease who successfully completed Study GAU-CL-202 (NCT00446550). Participants could enter the study immediately upon completion of participation in the lead-in study GAU-CL-202, or at any later time point. Participants received 225 milligram (mg) afegostat tartrate, administered orally for 30 months, and remained in 1 of the 2 randomized treatment regimens of Study GAU-CL-202: afegostat tartrate once daily (QD) for 3 consecutive days, then no afegostat tartrate for 4 consecutive days (consecutive 3-days-on/4-days-off) or QD for 7 consecutive days, then no afegostat tartrate for 7 days (consecutive 7-days-on/7-days-off). Amendment 2 removed the 7-days-on/7-days-off regimen and added an alternative 3-days-on/4-days-off regimen: afegostat tartrate QD on Monday, Wednesday, and Friday, then no afegostat tartrate on Tuesday, Thursday, Saturday, and Sunday (MWF 3-days-on/4-days-off). Once ...
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Potassium sodium tartrate
Potassium sodium tartrate Potassium sodium tartrate IUPAC name Potassium sodium tartrate Other names E337 Identifiers CAS number 304-59-6 EINECS number
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Conditions Modifying The Action Of Antimony - Tolerance. Antimony (Antimonium, Stibium) Treatment
The preceding description requires to be qualified, especially in cases of what is called tolerance. If the giving of antimony be commenced in fractional doses, and continued with very gradual incre...
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Article Preparation and characterization of iron-copper binary oxide and its effective removal of antimony(III) from aqueous solution. An Fe-Cu binary oxide was fabricated through a simple co-precipitation process, and was used to remove Sb(III) from...
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Upadacitinib tartrate, an orally available, small-molecule selective inhibitor of JAK1, was recently approved in the U.S. as a treatment for
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May cause eye, skin, and respiratory Spain. : P/6880/60, P/6880/62, P/6880/53 Synonyms Seignette salt; Rochelle salt CAS-No 6381-59-5 Molecular Formula C4 H4 K Na O6 . SAFETY DATA SHEETS According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition. Potassium sodium tartrate tetrahydrate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. This SDS, and the associated product, is intended for use only by technically qualified ... Potassium sodium tartrate is listed in the TSCA inventory. Potassium sodium tartrate 6381-59-5 100 Toxicological Data on Ingredients: Potassium sodium tartrate LD50: Not available. Catalog Numbers:AC202860000, AC202860050, 20286-0010, 20286-5000, S386-12, S386-212, S386- 500, S387-10, S387-3, S387-500. POTASSIUM TARTRATE. If not Product Identification. Catalog Number 108087 Product Name Potassium sodium tartrate tetrahydrate. If not breathing, give artificial ...
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AUTHOR: ILO, ELOCHUKWU CAJETAN DEPARTMENT: APPLIED MICROBIOLOGY AND BREWING AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA The rat sub-chronic toxicity study (dose-response relationship) and the assessment of Antimony concentration in Nigerian bottled water samples (exposure assessment) were the two complimentary studies that sought to estimate the Antimony risk in Nigeria via drinking water. The rat sub-chronic toxicity study…
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Antimony: A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
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Antimony Trioxide is mainly produced via the smelting of stibnite ore.It can be readily oxidized to antimony pentoxide and related antimony (V) compounds.
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He began treating patients with potassium antimony tartrate. Later, he used an organic preparation of antimony. Over time, ... "Antimony in the Treatment of Kala-azar and its Toxic Effects", Chinese Medical Journal, Vol. 47: 1421-33, 1933 "The Treatment ...
Antimony potassium tartrate, an anion, that forms diastereomeric salts with chiral cations. Camphorsulfonic acid, an acid that ... In 1882 he went on to demonstrate that by seeding a supersaturated solution of sodium ammonium tartrate with a d-crystal on one ... Louis Pasteur exploited this phenomenon by the manual separation of left-handed and right-handed sodium ammonium tartrate ...
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Chemical analysis showed that it contained antimony potassium tartrate, also called "emetic tartar"; which in addition to ...
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He discovered that antimony potassium tartrate was an effective drug in the treatment of bilharzia. Although it had severe side ... The next generation of drugs also contained antimony and were in use until the 1970s. He was President of the tropical diseases ... Christopherson, J. B. (1918). "The Successful Use of Antimony in Bilharziosis" (PDF). The Lancet. 192 (4958): 325. doi:10.1016/ ... effects, this treatment, which involved the use of antimony derivates, was the state of the art until the 1950s. ...
A combination of tartar emetic (antimony potassium tartrate) and emetine hydrochloride healed the skin lesions. For elimination ... Kemper, H.E. and I.H. Roberts (1946) "Treatment of filarial dermatosis of sheep with antimony compounds." American Journal of ...
John Brian Christopherson published his discovery that antimony potassium tartrate was an effective cure for bilharzia. The ... "The Successful Use of Antimony in Bilharziosis". The Lancet. 192 (4958): 325. doi:10.1016/S0140-6736(01)02807-0. "National ...
It can be a substitute for antimony potassium tartrate(emetic tartar) when making red and brown dyes. "Titanium acetate". ...
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September 7 - J. B. Christopherson publishes his discovery that antimony potassium tartrate is an effective cure for bilharzia ... Christopherson, J. B. (1918). "The Successful Use of Antimony in Bilharziosis". The Lancet. 192 (4958): 325. doi:10.1016/S0140- ...
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Antimony potassium tartrate - K2Sb2(C4H2O6)2 ... Potassium sodium tartrate - KNaC4H4O6. *Potassium sulfate - K2 ...
Historically, antimony potassium tartrate remained the treatment of choice for schistosomiasis until the development of ... Walker MD (August 2018). "Etymologia: Antimony". Emerg. Infect. Dis. 24 (8): 1601. doi:10.3201/eid2408.et2408. citing public ...
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... potassium sodium tartrate, a mild laxative), and tartar emetic (antimony potassium tartrate). Diisopropyl tartrate is used as a ... The former byproducts mostly consist of potassium bitartrate (KHC4H4O6). This potassium salt is converted to calcium tartrate ( ... The tartrates remaining on the inside of aging barrels were at one time a major industrial source of potassium bitartrate. ... antimony(III) d-tartrate) octahydrate". Inorganic Chemistry. 12 (7): 1641-1646. doi:10.1021/ic50125a033. Haq, I; Khan, C (1982 ...
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When heated with potassium bitartrate, a complex salt potassium antimony tartrate, KSb(OH)2•C4H2O6 is formed. The structure of ... Antimony metal is oxidized to antimony(III) oxide in furnaces. The reaction is exothermic. Antimony(III) oxide is formed ... Antimony(III) oxide has suspected carcinogenic potential for humans. Its TLV is 0.5 mg/m3, as for most antimony compounds. No ... Antimony(III) oxide is the inorganic compound with the formula Sb2O3. It is the most important commercial compound of antimony ...
Tartar emetic is produced when potassium tartrate is heated with antimony trioxide. Tartar emetic causes intense nausea, ... Potassium tartrate is produced by the reaction of tartaric acid with potassium sodium tartrate (rochelle salt), and potassium ... Potassium tartrate, dipotassium tartrate or argol has formula K2C4H4O6. It is the potassium salt of tartaric acid. It is often ... As a food additive, it shares the E number E336 with potassium bitartrate. ...
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List of MeSH codes (D02)
... antimony sodium gluconate MeSH D02.241.081.844.322.200 - calcium gluconate MeSH D02.241.081.844.387 - glyceric acids MeSH ... potassium citrate MeSH D02.241.081.944.509 - pentanoic acids MeSH D02.241.081.944.509.350 - gemfibrozil MeSH D02.241.081.944. ... tartrates MeSH D02.241.081.844.821 - tartronates MeSH D02.241.081.844.915 - uronic acids MeSH D02.241.081.844.915.325 - ... antimony sodium gluconate MeSH D02.241.511.902.322.200 - calcium gluconate MeSH D02.241.511.902.387 - glyceric acids MeSH ...
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Picrotoxin Piperidine Pirimifos-ethyl Plutonium Polonium-210 Potassium arsenite Potassium cyanide Potassium silver cyanide ... Antimony pentafluoride Antimycin A ANTU (Alpha-Naphthylthiourea) Arsenic pentoxide Arsenous oxide Arsenous trichloride Arsine ... phenylthiophosphonate Ergocalciferol Ergotamine tartrate Ethanesulfonyl chloride, 2-chloro- Ethanol, 1,2-dichloro-, acetate ...
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Potassium Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic ... Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium Gadolinium ... Bunsen was able to reduce rubidium by heating charred rubidium tartrate. Although the distilled rubidium was pyrophoric, they ... Rubidium is very similar to potassium, and tissue with high potassium content will also accumulate the radioactive rubidium. ...
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TrihydrateTartar EmeticAntimonylCompoundsTrioxideTrivalent antimonySynonymsHydrogen tartratePentavalent antimonyMeglumineToxicitySaltsSchistosomiasisLevels of antimonyChemicalPowderInvolved in antimony resistancePoisonousToxicPraziquantelAlumDipotassiumSymptomsInhalation of antimonyConcentration of antimonyProductsCalciumLeishmaniaKnown as potassium1551ExposureLeishmaniasisSb2O3MetallicSulfideDosesSuppliersEcologicalPentafluorideCardiacTartaricIngestionMolecular Formula
- Product name Antimony potassium tartrate trihydrate Product number FA35320 CAS number 28300-74-5 EC number 234-293-3 1.2. (clarkwaterproofing.com)
- Shop a large selection of products and learn more about Antimony Potassium Tartrate Trihydrate (USP), Fisher Chemical. (clarkwaterproofing.com)
- 58 / Monday, March 26, 2012 / Rules and Regulations 07/22/2020 EN (English US) 6/8 Potassium Antimony Tartrate, Trihydrate (28300-74-5) ErC50 (algae) 206 mg/l (OECD 201: Alga, Growth Inhibition Test, 72 h, Pseudokirchneriella subcapitata, It is also used in the textile industry to aid in binding certain dyes to fabrics. (clarkwaterproofing.com)
- Listing your company for Antimony potassium tartrate trihydrate allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo! (poulvet.com)
- Potassium antimonyl d-tartrate Antimony Potassium Tartrate, Powder , also called Tartar Emetic, is a poisonous efflorescent crystalline salt of sweetish metallic taste that was formerly used in medicine as an emetic and expectorant. (clarkwaterproofing.com)
- Potassium antimony tartrate (tartar emetic), sodium antimony tartrate, the thioxanthone, hycanthone, and the 5-nitrothiazole, niridazole, were formerly used in the treatment of schistosomiasis, but have been largely superseded by less toxic compounds. (glorystudio.com.ua)
- The next most toxic form is antimony potassium tartrate, a trivalent form of the metal that is available in many countries as tartar emetic (used for treatment of alcohol abuse). (uc.pt)
- Antimony potassium tartrate (tartar emetic) is still used today as the preferred treatment for blood flukes (schistosomiasis or Bilharziasis). (uc.pt)
- Antimony and its compounds do not cause acute human health effects, with the exception of antimony potassium tartrate ("tartar emetic"), a prodrug that is intentionally used to treat leishmaniasis patients. (uc.pt)
- Tartar emetic is produced when potassium tartrate is heated with antimony trioxide. (uc.pt)
- At the beginning of the last century, Gaspar Vianna, pioneer researcher in the treatment of leishmaniasis, reported the efficacy of antimony(III) potassium tartrate (tartar emetic) for treatment of leishmaniasis ( 1 ). (asm.org)
- The use of tartar emetic (antimony and potassium tartrate) in preference to Fuadin has been emphasized properly, in combatting schistosomal infections. (ajtmh.org)
- Not all physicians using tartar emetic are aware, I believe, of the need for beginning with very small doses and after some tolerance to antimony has developed, build up the dose to much higher levels than originally possible. (ajtmh.org)
- Tartar emetic (hydrated potassium antimony tartrate) has been used in medicine. (rasayantrading.com)
- Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar, has the formula K2Sb2(C4H2O6)2. (wikipedia.org)
- In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration-approved chemical drugs. (aspetjournals.org)
- Potassium antimonyl tartrate sesquihydrate , its cas register number is 28300-74-5. (glorystudio.com.ua)
- potassium antimonyl tartrate), meglumine antimoniate, sodium stibogluconate, and other compounds are used as medicines. (uc.pt)
- We describe here the use of functional cloning where an expression cosmid bank derived from Leishmania infantum was transfected in L. infantum axenic amastigotes and selected for potassium antimonyl tartrate (SbIII) resistance. (sigmaaldrich.com)
- Trivalent antimony compounds are more toxic than the pentavalent because they are excreted slowly. (clarkwaterproofing.com)
- Antimony potassium tartrate is the most potent and most toxic of the trivalent antimony compounds. (glorystudio.com.ua)
- Selected antimony compounds are used in the treatment of protozoans. (uc.pt)
- Two antimony compounds (sodium stibogluconate and antimony potassium tartrate) have been used as antiparasitic medications. (cdc.gov)
- Urinary excretion appears to be greater for pentavalent antimony than for trivalent compounds (Elinder and Friberg, 1986). (cdc.gov)
- ingestion of antimony compounds, and rarely industrial exposure to them, may produce symptoms similar to those of acute arsenic poisoning. (thefreedictionary.com)
- Antimony compounds are used in the treatment of filariasis, leishmaniasis, and other parasitic diseases. (thefreedictionary.com)
- Trivalent and pentavalent antimony compounds are used in medicine as anti-infective agents in the treatment of tropical diseases, especially those of protozoan origin. (thefreedictionary.com)
- All antimony compounds are potentially poisonous and must be used with caution. (thefreedictionary.com)
- Antimony trioxide, together antimony tetroxide and antimony pentoxide, are the current three compounds forming between antimony and oxygen with industrial application. (chemicalbook.com)
- However, only the first three compounds have significance in industrial production with other oxides mostly being the transition product of various kinds of antimony production process. (chemicalbook.com)
- Antimony compounds have been used as medicines since their introduction by the alchemist John of Rupescissa in the 14th century [ 4 ], mainly in the treatment of two parasitic diseases, leishmaniasis and schistosomiasis. (mdpi.com)
- Antimony and its compounds are naturally present in the Earth's crust and are released into the environment by natural discharges such as windblown dust, volcanic eruptions, sea spray, forest fires, and biogenic sources. (mdpi.com)
- In the same century, a book summarizing available knowledge of antimony and its compounds was purportedly written by a Basil Valentine, allegedly a Benedictine monk of the 15th century, whose name appears on chemical writings over a span of two centuries. (britannica.com)
- Highly purified antimony is used in semiconductor technology to prepare the intermetallic compounds indium , aluminum , and gallium antimonide for diodes and infrared detectors. (britannica.com)
- a toxic effect caused by the ingestion or inhalation of antimony or antimony compounds. (thefreedictionary.com)
- Antimony and antimony compounds are common ingredients of many substances used in medicine and industry. (thefreedictionary.com)
- Antimony trioxide Sb2O3 is one of the most important antimony compounds which has a large number of industrial applications. (thefreedictionary.com)
- Antimony compounds are easy to be hydrolyzed in aqueous solutions, which makes difficult to synthesize their complexes , so the study of antimony complexes is much less than that of transition metal and rare earth metal complexes. (thefreedictionary.com)
- Antimony potassium tartrate is prepared by treating a solution of potassium hydrogen tartrate and antimony trioxide: 2 KOH + Sb2O3 + (HOCHCO2H)2 → K2Sb2(C4H2O6)2 + 3 H2O With an excess of tartaric acid, the monoanionic monoantimony salt is produced: 2 KOH + Sb2O3 + 4 (HOCHCO2H)2 → 2 KSb(C4H2O6)2 + 2 H2O The structure of both salts have been determined by X-ray crystallography. (wikipedia.org)
- Antimony potassium tartrate can be prepared by refluxing a solution of potassium hydrogen tartrate and antimony trioxide for 15 minutes. (glorystudio.com.ua)
- Antimony is found in ores or other minerals, often combined with oxygen to form antimony trioxide or with sulfur to form stibnite. (cdc.gov)
- Antimony trioxide is rated by IARC as a possible human carcinogen. (cdc.gov)
- Antimony trioxide (Sb2O3, Mr291.50) is a dual-type substance including cubic crystal and monoclinic crystal type. (chemicalbook.com)
- Antimony trioxide is a kind of white powder with the density being 5.67g/cm3. (chemicalbook.com)
- Antimony trioxide has a low toxicity but has irritation effect on nose, eyes, throat and respiratory tract. (chemicalbook.com)
- Antimony trioxide mainly has two preparation methods including dry and wet. (chemicalbook.com)
- Dry method is through reducing the crude sulfur trioxide generated from the calcined sulfantimonide ore into metallic antimony in the presence of coke with soda as the melting promoting agent. (chemicalbook.com)
- In addition antimony trioxide is possibly carcinogenic to humans. (mdpi.com)
- Occupational exposure to antimony occurs mainly in workers involved in industries producing antimony and antimony trioxide, metal mining, smelting and refining, coal-fired power plants, refuse incineration, or those working in indoor firing ranges. (mdpi.com)
- from antimony potassium tartrate Production method Category Toxicity grading Acute toxicity Flammability and hazardous characteristics Storage characteristics Extinguishing agent Professional standards Product Name: Diantimony trioxide Synonyms: DI. (chinacsw.com)
- The New England Journal of Medicine reported a case study of a patient whose wife secretly gave him a dose of a product called "tartaro emetico" which contained trivalent antimony (antimony potassium tartrate) and is sold in Central America as an aversive treatment for alcohol abuse. (wikipedia.org)
- Potassium antimony tartrate is the most potent trivalent antimony compound. (clarkwaterproofing.com)
- Morphological changes were evaluated by transmission electron microscopy after trivalent antimony exposure. (scielo.br)
- P-glycoprotein (P-gp) efflux pump activity was evaluated using the pump-specific inhibitor verapamil hydrochloride, and the role of thiol in trivalent antimony resistance was investigated using the enzymatic inhibitor L-buthionine sulfoximine. (scielo.br)
- Importantly, the resistant isolates contained higher levels of thiol compared to the sensitive isolates, and inhibition of thiol synthesis in the resistant isolates recovered their sensitivity to trivalent antimony treatment, and enhanced the production of reactive oxygen species in promastigotes exposed to the drug. (scielo.br)
- In an effort to determine whether trivalent antimony (7440360) affects intracellular free calcium concentration during excitation and contraction, the authors developed an in-vitro cardiac myocyte model that was exposed for 24 hours to potassium-antimony-tartrate (28300745) (PAT) up to concentrations of 10 microM. (cdc.gov)
- Potassium bitartrate, also known as potassium hydrogen tartrate, with formula KC 4 H 5 O 6, is a byproduct of winemaking.In cooking it is known as cream of tartar.It is processed from the potassium acid salt of tartaric acid (a carboxylic acid). (maati.nl)
- The report generally describes potassium hydrogen tartrate(cream of tartar), examines its uses, production methods, patents. (marketpublishers.com)
- potassium hydrogen tartrate(cream of tartar) manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
- Furthermore, potassium hydrogen tartrate(cream of tartar) prices in regional markets can be found in the report with regards to countries and companies. (marketpublishers.com)
- The report also focuses on potassium hydrogen tartrate(cream of tartar) consumers by providing data on companies that use it. (marketpublishers.com)
- POTASSIUM HYDROGEN TARTRATE(CREAM OF TARTAR) (CAS 868-14-4) Market Research Report 2018 contents were worked out and placed on the website in February, 2018. (marketpublishers.com)
- Please note that POTASSIUM HYDROGEN TARTRATE(CREAM OF TARTAR) (CAS 868-14-4) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
- Potassium bitartrate , also known as potassium hydrogen tartrate , with formula KC 4 H 5 O 6 , is a byproduct of winemaking. (rasayantrading.com)
- The less toxic pentavalent antimony [Sb(V)] complexes, including meglumine antimoniate (Glucantime [Glu]), were introduced for the therapy of leishmaniasis from the 1940s. (asm.org)
- We evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony. (scielo.br)
- After the introduction of antimony(V) containing complexes like sodium stibogluconate and meglumine antimoniate, the use of antimony potassium tartrate was phased out. (wikipedia.org)
- OSHA SDS #: 25167 rev 101 10.7.2015 Toxicity Data: Antimony potassium tartrate LD50 (oral, rat) 115 mg/m3 14. (clarkwaterproofing.com)
- Antimony potassium tartrate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. (maati.nl)
- Antimony toxicity occurs either due to occupational exposure or during therapy. (mdpi.com)
- Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. (mdpi.com)
- This review discusses antimony toxicity arising from occupational exposure and when it is used as a therapy. (mdpi.com)
- Toxicity Acute antimony trichloride poisoning is rare. (inchem.org)
- Inorganic antimony salts irritate the mucous membranes, skin, and eyes. (cdc.gov)
- Antimony oxide can be used in fire-retardant formulations for plastics, rubbers, textiles, paper and paints whereas antimony trisulfide is used in the production of explosives, pigments, antimony salts and ruby glass [ 1 - 3 ]. (mdpi.com)
- After British physician John Brian Christopherson's discovery in 1918 that antimony potassium tartrate could cure schistosomiasis, the antimonial drugs became widely used. (wikipedia.org)
- Antimony potassium tartrate hydrate is a compound used in the treatment of schistosomiasis. (clarkwaterproofing.com)
- As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. (mdpi.com)
- One hundred years ago, John Brian Christopherson (1868-1955) discovered that antimony potassium tartrate ( Figure ) was an effective treatment against schistosomiasis. (cdc.gov)
- Antimony potassium tartrate remained the treatment of choice for schistosomiasis until the development of praziquantel in the 1980s. (cdc.gov)
Levels of antimony3
- Biomonitoring studies on levels of urinary antimony can provide physicians and public health officials with reference values so that they can determine whether people have been exposed to higher levels of antimony than are found in the general population. (cdc.gov)
- Canadians may be exposed to the 11 antimony-containing substances, which include both trivalent and pentavalent forms of antimony, as they contribute to levels of antimony in environmental media, food, drinking water and/or products available to consumers. (canada.ca)
- These data show that the general population is exposed to low levels of antimony. (mdpi.com)
- Ruger Chemical Co. Ltd. manufactures caffeine, hydroxy ethyl cellulose and potassium iodide. (chemicalregister.com)
- Antimony potassium tartarate hemihydrate is often used for quantification of phosphate using ammonium molybdate method with ascorbic acid as a reducing … Antimony is a metallic element with the chemical symbol Sb and atomic number 51. (uc.pt)
- Antimony can exist in one of four valences in its various chemical and physical forms: -3, 0, +3, and +5. (cdc.gov)
- Even when added in minor quantities, antimony imparts strength and hardness to other metals, particularly lead, with which it forms alloys used in plates of automobile storage batteries, in bullets, in coverings for cables, and in chemical equipment such as tanks, pipes, and pumps. (britannica.com)
- ANTIMONY TRICHLORIDE Toxbase summary Type of product Used as a chemical reagent and in veterinary practice. (inchem.org)
Involved in antimony resistance1
- P-gp efflux activity was not involved in antimony resistance in these isolates. (scielo.br)
- Another form, antimony potassium tartrate, is a highly toxic insecticide. (uc.pt)
- With the introduction and subsequent larger use of praziquantel in the 1970s, antimony-based treatments fell out of use. (wikipedia.org)
- Section 8 - Exposure Controls, Personal Protection Engineering Controls: Dipotassium tartrate. (clarkwaterproofing.com)
- Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. (mdpi.com)
Inhalation of antimony1
- Acute inhalation of antimony has been associated with irritation of the respiratory tract and impaired pulmonary function (Renes, 1953). (cdc.gov)
Concentration of antimony2
- The concentration of antimony in air ranges from a nanogram per cubic meter (ng/m 3 ) to about 170 ng/m 3 . (mdpi.com)
- The concentration of antimony that is found dissolved in rivers and lakes is usually less than 5 parts of antimony in 1 billion parts of water (ppb) and it is found attached to particles of dirt. (mdpi.com)
- When operational, the 20,000-tonnes-per-annum capacity project will account for a significant chunk of total global production of antimony products and position the sultanate as a world-scale producer, it said. (thefreedictionary.com)
- Our range of products include potassium bitratrate, sodium citrate, antimony potassium tartarate, sodium potassium tartrate, potassium citrate and calcium citrate. (rasayantrading.com)
- The incubation mixture contained diluted tissue homogenates, sodium- chloride (7647145), potassium-chloride (7447407), calcium-chloride (10043524), and magnesium-chloride (7786303) in various concentrations. (cdc.gov)
- When added together, potassium did not increase the enzyme activity beyond that shown by calcium alone. (cdc.gov)
- Sodium and potassium by themselves or in combination did not stimulate the enzyme unless calcium or magnesium were present. (cdc.gov)
- PAT exposed cells also demonstrated a reduced basal intracellular calcium concentration when depolarized by 90 mM potassium-chloride and a reduced caffeine releasable calcium pool of the sarcoplasmic reticulum. (cdc.gov)
- The treatment of leishmania with antimony potassium tartrate started in 1913. (wikipedia.org)
- Manzano JI, García-Hernández R, Castanys S, Gamarro F. A new ABC half-transporter in Leishmania major is involved in resistance to antimony. (scielo.br)
- A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes. (sigmaaldrich.com)
Known as potassium1
- Antimony potassium tartrate, also known as potassium antimony tartrate, potassium antimontarterate, formula K2Sb2 (C4H2O6)2 and is the double salt of potassium and antimony of tartaric acid. (clarkwaterproofing.com)
- Antimony Potassium Tartrate: U.N.: 1551- CAS: 11071-15-1 28300-74-5 - EINECS: 234-293-3 - CE: 051-003-00-9. (uc.pt)
- Numerous reports describe gastrointestinal complications of vomiting, diarrhea and stomatitis associated with antimony exposure. (glorystudio.com.ua)
- Dermal contact with soil, water, or other substances containing antimony is another means of exposure. (cdc.gov)
- Workplace standards and recommendations for air exposure to antimony have been established by OSHA and ACGIH, respectively, and a drinking water standard has been established by the U.S. EPA. (cdc.gov)
- Levels of urinary antimony reflect recent exposure. (cdc.gov)
- 1998). Several investigations of airborne antimony exposures in workers have found urinary levels that are many times higher than those seen in NHANES 1999-2000, 2001-2002, and 2003-2004, even when exposure levels were below workplace air standards (Bailly et al. (cdc.gov)
- The ecological risks of the 11 substances in the Antimony-containing Substances Group were characterized using the Ecological Risk Classification of Inorganic Substances (ERC-I). The ERC-I is a risk-based approach that employs multiple metrics considering both hazard and exposure in a weight of evidence. (canada.ca)
- Exposure profiling considered two approaches: predictive modeling using a generic near-field exposure model for each substance, and an analysis of measured concentrations collected by federal and provincial water quality monitoring programs using antimony concentrations as a conservative indicator of exposure for the 11 substances. (canada.ca)
- Antimony had been previously used against visceral leishmaniasis, Trypanosoma brucei gambiense , and yaws. (cdc.gov)
- Antimony can form a series of oxide with oxygen such as Sb2O3, Sb2O4, Sb2O5, Sb6O13, and Sb2O as well as gaseous SbO. (chemicalbook.com)
- Antimony sulfide (Sb 2 S 3) is mentioned in an Egyptian papyrus of the 16 th century BC. (maati.nl)
- The ancients were familiar with antimony both as a metal and in its sulfide form. (britannica.com)
- The Old Testament tells of Queen Jezebel using the naturally occurring sulfide of antimony to beautify her eyes. (britannica.com)
- Pliny, during the 1st century ad , wrote of seven different medicinal remedies using stibium or antimony sulfide. (britannica.com)
- Human health effects from antimony at low environmental doses or at biomonitored levels from low environmental exposures are unknown. (cdc.gov)
- Small amounts of antimony … Antimony Potassium Tartrate Flinn Scientific, Inc. P.O. Find here antimony potassium tartrate dealers in Kala Amb with traders, distributors, wholesalers, manufacturers & suppliers. (uc.pt)
- The ERC-I identified these 11 antimony-containing substances as having low ecological concern. (canada.ca)
- Another research titledGlobal and Chinese Antimony Pentafluoride (CAS 7783-70-2) Industry, 2015 Market Research Report is a professional and in-depth study on the current state of the global Antimony Pentafluoride industry with a focus on the Chinese market. (thefreedictionary.com)
- Ingestion - Antimony trichloride ingestion will cause burning of the mouth and throat with retrosternal and abdominal pain, nausea and vomiting. (inchem.org)
- 6. If systemic features develop treat as for antimony (see separate entry) Ingestion 1. (inchem.org)
- Poisoning caused by ingestion of antimony. (thefreedictionary.com)
- Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid with the molecular formula K 3 C 6 H 5 O 7 . (rasayantrading.com)