AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Antimitotic AgentsColchicineTubulin ModulatorsTubulinGriseofulvinVinca AlkaloidsMitosisVinblastineMicrotubulesPaclitaxelAntineoplastic AgentsStructure-Activity RelationshipCell Line, TumorMaytansineDepsipeptidesOxazolesCell CycleAging, PrematureMacrolidesEpothilonesCyclin-Dependent Kinase Inhibitor p27ApoptosisNeural CrestOrthopedic Fixation DevicesEnteric Nervous SystemNeuroblastomaCells, CulturedCombretumTaxoidsProstatic NeoplasmsTranslatingProstateBreast NeoplasmsGenetic VariationHydrazonesHydrazinesGlioblastomaCell ProliferationPatents as TopicForamen Ovale, PatentPodophyllinPodophyllotoxinWartsKeratolytic AgentsSkin Diseases, GeneticCondylomata AcuminataAnesthesia, ConductionAnesthesia, LocalAnesthesia, GeneralAnesthesiaSleepAnesthesia, SpinalAnesthesia, Epidural
Antimitotic Agents
Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.
Colchicine
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
Tubulin Modulators
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
Tubulin
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Griseofulvin
An antifungal agent used in the treatment of TINEA infections.
Vinca Alkaloids
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Mitosis
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Vinblastine
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Microtubules
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
Paclitaxel
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Maytansine
An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
Depsipeptides
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
Oxazoles
Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Aging, Premature
Changes in the organism associated with senescence, occurring at an accelerated rate.
Macrolides
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
Epothilones
A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).
Cyclin-Dependent Kinase Inhibitor p27
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Orthopedic Fixation Devices
Devices which are used in the treatment of orthopedic injuries and diseases.
Enteric Nervous System
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Combretum
A plant genus of the family COMBRETACEAE. Triterpenes and combretastatin have been identified in members of this genus.
Taxoids
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.
Translating
Conversion from one language to another language.
Prostate
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Breast Neoplasms
Tumors or cancer of the human BREAST.
Genetic Variation
Genotypic differences observed among individuals in a population.
Hydrazones
Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)
Hydrazines
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Cell Proliferation
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Foramen Ovale, Patent
A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.
Podophyllin
Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.
Podophyllotoxin
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Warts
Benign epidermal proliferations or tumors; some are viral in origin.
Keratolytic Agents
Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
Skin Diseases, Genetic
Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.
Condylomata Acuminata
Sexually transmitted form of anogenital warty growth caused by the human papillomaviruses.
Anesthesia, Conduction
Injection of an anesthetic into the nerves to inhibit nerve transmission in a specific part of the body.
Anesthesia, Local
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
Anesthesia, General
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Sleep
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Anesthesia, Spinal
Procedure in which an anesthetic is injected directly into the spinal cord.
Anesthesia, Epidural
Procedure in which an anesthetic is injected into the epidural space.

Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes. (1/74)

Xenopus oocytes are arrested at the G2/prophase boundary of meiosis I and enter meiosis in response to progesterone. A hallmark of meiosis is the absence of DNA replication between the successive cell division phases meiosis I (MI) and meiosis II (MII). After the MI-MII transition, Xenopus eggs are locked in metaphase II by the cytostatic factor (CSF) arrest to prevent parthenogenesis. Early Mitotic Inhibitor 1 (Emi1) maintains CSF arrest by inhibiting the ability of the Anaphase Promoting Complex (APC) to direct the destruction of cyclin B. To investigate whether Emi1 has an earlier role in meiosis, we injected Xenopus oocytes with neutralizing antibodies against Emi1 at G2/prophase and during the MI-MII transition. Progesterone-treated G2/prophase oocytes injected with anti-Emi1 antibody fail to activate Maturation Promoting Factor (MPF), a complex of cdc2/cyclin B, and the MAPK pathway, and do not undergo germinal vesicle breakdown (GVBD). Injection of purified Delta90 cyclin B protein or blocking anti-Emi1 antibody with purified Emi1 protein rescues these meiotic processes in Emi1-neutralized oocytes. Acute inhibition of Emi1 in progesterone treated oocytes immediately after GVBD causes rapid loss of cdc2 activity with simultaneous loss of cyclin B levels and inactivation of the MAPK pathway. These oocytes decondense their chromosomes and enter a DNA replication phase instead of progressing to MII. Prior ablation of Cdc20, addition of methyl-ubiquitin, or addition of nondestructible Delta90 cyclin B rescues the MI-MII transition in Emi1-inhibited oocytes.  (+info)

Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53. (2/74)

OBJECTIVE: Drug-eluting stents containing the immunosuppressant rapamycin markedly inhibit in stent restenosis (ISR). However, the molecular mechanisms that underlie its effect on ISR-derived vascular smooth muscle cells (VSMCs), as opposed to normal VSMCs, are unknown. Specifically, as ISR-VSMCs have altered cell cycle regulation, rapamycin may arrest these cells via novel molecular pathways. METHODS: We isolated human VSMCs from sites of ISR, and examined the effect of rapamycin on cell proliferation using MTT assay, time lapse videomicroscopy and flow cytometry. Regulation of G(1)-S transition was examined using Western blotting, and cell size and protein synthesis examined using flow cytometry and collagen assay, respectively. The requirement for pRB and p53 was examined using ISR VSMCs expressing E1A and a dominant negative p53, respectively. RESULTS: ISR-VSMC proliferation was potently inhibited by rapamycin. Arrest was confined to G(1), as cell proliferation (but not cell size) of S/G(2)-arrested cells was unaffected by rapamycin. Moreover, ISR-VSMC lines generated with disrupted p53 or pRB function still arrested in the presence of rapamycin, suggesting that these genes are dispensable for rapamycin-induced arrest. Significantly, rapamycin completely inhibited the phosphorylation of p70(S6K), an mTOR-regulated kinase implicated in the control of proliferation, but had no effect on collagen or total protein synthesis. CONCLUSIONS: We demonstrate that rapamycin is a potent inhibitor of ISR VSMC proliferation during G(1). Rapamycin's action does not require p53 or pRB. We show that p70(S6K) is markedly inhibited in rapamycin-arrested ISR cells, suggesting that regulation of its upstream kinase, mTOR, is important for the control of proliferation in ISR cells.  (+info)

The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. (3/74)

E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of the marine sponge natural product halichondrin B. Whereas its mechanism of action has not been fully elucidated, its main target seems to be tubulin and/or the microtubules responsible for the construction and proper function of the mitotic spindle. Like most microtubule-targeted antitumor drugs, it inhibits tumor cell proliferation in association with G(2)-M arrest. It binds to tubulin and inhibits microtubule polymerization. We examined the mechanism of action of E7389 with purified microtubules and in living cells and found that, unlike antimitotic drugs including vinblastine and paclitaxel that suppress both the shortening and growth phases of microtubule dynamic instability, E7389 seems to work by an end-poisoning mechanism that results predominantly in inhibition of microtubule growth, but not shortening, in association with sequestration of tubulin into aggregates. In living MCF7 cells at the concentration that half-maximally blocked cell proliferation and mitosis (1 nmol/L), E7389 did not affect the shortening events of microtubule dynamic instability nor the catastrophe or rescue frequencies, but it significantly suppressed the rate and extent of microtubule growth. Vinblastine, but not E7389, inhibited the dilution-induced microtubule disassembly rate. The results suggest that, at its lowest effective concentrations, E7389 may suppress mitosis by directly binding to microtubule ends as unliganded E7389 or by competition of E7389-induced tubulin aggregates with unliganded soluble tubulin for addition to growing microtubule ends. The result is formation of abnormal mitotic spindles that cannot pass the metaphase/anaphase checkpoint.  (+info)

The mitotic checkpoint in cancer therapy. (4/74)

The mitotic checkpoint is a key cell cycle control mechanism that ensures an accurate segregation of chromosomes during mitosis by delaying the onset of anaphase until all chromosomes are properly attached to a bipolar mitotic spindle. While complete loss of this checkpoint is lethal in vertebrates, a weakened mitotic checkpoint is frequently seen in cancer cells and it may contribute to tumorigenesis. Many anti-tumor drugs, including spindle assembly inhibitors and DNA damaging agents, can activate the mitotic checkpoint. However, since these drugs influence interphase events besides activating the mitotic checkpoint, the role of the mitotic checkpoint in drug-induced cell death remained unclear. Using a KSP antagonist that specifically acts on mitotic cells, we have recently shown that activation of the mitotic checkpoint followed by mitotic slippage or adaptation, activates Bax and initiates apoptosis. Notably, cells with a weakened mitotic checkpoint incur much less apoptotic death than their checkpoint-proficient counterparts, indicating the requirement of a competent mitotic checkpoint in the induction of apoptosis. In light of these findings and other recent reports, the potential influence of the mitotic checkpoint in response to chemotherapies, and the strategy to target the mitotic checkpoint for cancer therapeutics are discussed.  (+info)

Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice. (5/74)

There is increasing evidence that more than 70% of cancers including pancreatic, breast and prostate cancers as well as neurofibromatosis (NF) are highly addicted to abnormal activation of the Ser/Thr kinase PAK1 for their growth. So far FK228 is the most potent among the HDAC (histone deacetylase) inhibitors that block the activation of both PAK1 and another kinase AKT, downstream of PI-3 kinase. However, FK228 is still in clinical trials (phase 2) for a variety of cancers (but not for NF as yet), and not available for most cancer/NF patients. Thus, we have been exploring an alternative which is already in the market, and therefore immediately useful for the treatment of those desperate cancer/NF patients. Here we provide the first evidence that extracts of Chinese/ Japanese peppercorns (Zanthoxyli Fructus) from the plant Zanthoxylum piperitum called "Hua Jiao"/"Sansho", block selectively the key kinase PAK1, leading to the downregulation of cyclin D1. Unlike FK228, these extracts do not inhibit AKT activation at the concentrations that block either cancer growth or PAK1 activation. The Chinese pepper extract selectively inhibits the growth of NF1-deficient malignant peripheral nerve sheath tumor (MPNST) cells, without affecting the growth of normal fibroblasts, and suppresses the growth of NF1-deficient human breast cancer (MDA-MB-231) xenograft in mice. Our data suggest that these peppercorn extracts would be potentially useful for the treatment of PAK1-dependent NF such as MPNST, in addition to a variety of PAK1-dependent cancers including breast cancers.  (+info)

Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. (6/74)

BACKGROUND: Kinesin spindle proteins (KSP) are motor proteins that play an essential role in mitotic spindle formation. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell division during mitosis. The function of HsEg5 provides a novel target for the manipulation of the cell cycle and the induction of apoptosis. SB715992, an experimental KSP inhibitor, has been shown to perturb bipolar spindle formation, thus making it an excellent candidate for anti-cancer agent. Our major objective was a) to investigate the cell growth inhibitory effects of SB715992 on PC-3 human prostate cancer cell line, b) to investigate whether the growth inhibitory effects of SB715992 could be enhanced when combined with genistein, a naturally occurring isoflavone and, c) to determine gene expression profile to establish molecular mechanism of action of SB715992. METHODS: PC-3 cells were treated with varying concentration of SB715992, 30 microM of genistein, and SB715992 plus 30 microM of genistein. After treatments, PC-3 cells were assayed for cell proliferation, induction of apoptosis, and alteration in gene and protein expression using cell inhibition assay, apoptosis assay, microarray analysis, real-time RT-PCR, and Western Blot analysis. RESULTS: SB715992 inhibited cell proliferation and induced apoptosis in PC-3 cells. SB715992 was found to regulate the expression of genes related to the control of cell proliferation, cell cycle, cell signaling pathways, and apoptosis. In addition, our results showed that combination treatment with SB715992 and genistein caused significantly greater cell growth inhibition and induction of apoptosis compared to the effects of either agent alone. CONCLUSION: Our results clearly show that SB715992 is a potent anti-tumor agent whose therapeutic effects could be enhanced by genistein. Hence, we believe that SB715992 could be a novel agent for the treatment of prostate cancer with greater success when combined with a non-toxic natural agent like genistein.  (+info)

Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice. (7/74)

Previous studies have shown that renal injury initiated by a lethal dose of S-1,2-dichlorovinyl-l-cysteine (DCVC) progresses due to inhibition of cell division and hence renal repair, leading to acute renal failure (ARF) and death in mice. Renal injury initiated by low to moderate doses of DCVC is repaired by timely and adequate stimulation of renal cell division, tubular repair, restoration of renal structure and function leading to survival of mice. Recent studies have established that mice primed with a low dose of DCVC (15 mg/kg i.p.) 72 h before administration of a normally lethal dose (75 mg/kg i.p.) are protected from ARF and death (nephro-autoprotection). We showed that renal cell division and tissue repair stimulated by the low dose are sustained even after the lethal dose administration resulting in survival from ARF and death. If renal cell division induced by the low dose is indeed the critical mechanism of this autoprotection, then its ablation by the antimitotic agent colchicine (1.5 mg CLC/kg i.p.) should abolish autoprotection. The present interventional experiments were designed to test the hypothesis that DCVC autoprotection is due to stimulated cell division and tissue repair by the priming low dose. CLC intervention at 42 and 66 h after the priming dose resulted in marked progressive elevation of plasma blood urea nitrogen and creatinine resulting in ARF and death of mice. Light microscopic examination of hematoxylin and eosin-stained kidney sections revealed progression of renal necrosis concordant with progressively failing renal function. With CLC intervention, S-phase stimulation (as assessed by BrdU pulse labeling), G(1)-to-S phase clearance, and cell division were diminished essentially abolishing the promitogenic effect of the priming low dose of DCVC. Phospho-retinoblastoma protein (P-pRB), a crucial protein for S-phase stimulation, and other cellular signaling mechanisms regulating P-pRB were investigated. We report that decreased P-pRB via activation of protein phosphatase-1 by CLC is the critical mechanism of this inhibited S-phase stimulation and ablation of autoprotection with CLC intervention. These findings lend additional support to the notion that stimulated cell division and renal tissue repair by the priming dose of DCVC are the critical mechanisms that allow sustained compensatory tissue repair and survival of mice in nephro-autoprotection.  (+info)

A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities. (8/74)

We discovered a thalidomide analogue [5-hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33)] with antiproliferative activity against nine cancer cell lines in vitro. Flow cytometric analyses showed that the compound caused G2-M arrest, which occurred mainly at the mitotic phase. In addition, immunofluorescence microscopy and in vitro tubulin polymerization studies showed that 5HPP-33 has antimicrotubule activity with a paclitaxel-like mode of action. It is effective against four different paclitaxel-resistant cell lines. Thus, 5HPP-33 represents a potential antitumor agent.  (+info)

Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity | 10.1007/s11030...Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity | 10.1007/s11030...
Read Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/novel-antimitotic-agents-related-to-tubuloclustin-synthesis-and-jfH0w65NY0
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents - Publikationsserver der Universität RegensburgAroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents - Publikationsserver der Universität Regensburg
Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent derivatives. These 2-phenylindole derivatives also exerted an inhibitory effect on the growth of both proliferating and resting U-373 MG glioblastoma cells. Though the hydrazones exhibited similar structure-activity relationships as the aldehydes, they did not inhibit tubulin polymerization as the aldehydes but were capable of blocking the cell cycle in G(2)/M phase. The cell cycle arrest was accompanied by apoptosis as demonstrated by the activation of caspase-3. Since these 2-phenylindole-based hydrazones display no structural similarity with other antitumor drugs they are interesting candidates for further ...
https://epub.uni-regensburg.de/4787/
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural...Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural...
We describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination of antimitotic activity, In the assay, cells arrested in mitosis as a result of exposure to antimitotic agents in pure form or in crude natural extracts are detected by ELISA using the monoclonal antibody TG-3, The assay was used to screen ,24,000 extracts of marine microorganisms and invertebrates and terrestrial plants and to guide the purification of active compounds from 5 of 119 positive extracts. A new rhizoxin analogue was found in a Pseudomonas species, six new eleutherobin analogues were identified from the octocoral Erythropodium caribaeorum, and two paclitaxel analogues were found in the stem bark of the tree Ilex macrophylla. The assay was also used for quantitative comparison of the antimitotic activity of different analogues. It revealed the importance of the C-11 to C-13 segment of the diterpene core of eleutherobin for its antimitotic activity. The ...
https://chem.ubc.ca/cell-based-screen-antimitotic-agents-and-identification-analogues-rhizoxin-eleutherobin-and
Plus itPlus it
Intervention of cancer cell mitosis by antitubulin drugs is among the most effective cancer chemotherapies. However, antitubulin drugs have dose-limiting side effects due to important functions of microtubules in resting normal cells and are often rendered to be ineffective by rapid emergence of resistance. Antimitotic agents with different mechanisms of action and improved safety profiles are needed as new treatment options. Mitosis-specific kinesin Eg5 represents an attractive anticancer target for discovering such new antimitotic agents, because Eg5 is essential only in mitotic progression and has no roles in resting, non-dividing cells. Here we show that a novel selective Eg5 inhibitor LY2523355 has broad target-mediated anticancer activity in vitro and in vivo. LY2523355 arrests cancer cells at mitosis and causes rapid cell death that requires sustained spindle-assembly checkpoint (SAC) activation with a required threshold concentration. In vivo efficacy of LY2523355 is highly ...
http://mct.aacrjournals.org/content/early/2015/08/22/1535-7163.MCT-15-0241
Plus itPlus it
Patients with ovarian high-grade serous carcinoma (HGSC) initially respond to treatment with the chemotherapeutic agents carboplatin and paclitaxel, but frequently experience tumor relapse. However, the mechanisms underlying the development of resistance to these drugs remain poorly understood. Yu and colleagues found that the levels of spleen tyrosine kinase (SYK) and phosphorylated SYK were increased in recurrent ovarian tumors isolated from patients previously treated with carboplatin and paclitaxel compared with matched primary untreated tumors. In addition, SYK expression and activation were upregulated in paclitaxel-resistant ovarian cancer cell lines and positively correlated with paclitaxel response in vitro, suggesting that SYK overexpression may confer chemoresistance. SYK inactivation via knockdown or pharmacologic inhibition with the active metabolite of fostamatinib, R406, impaired the growth of ovarian cancer cells and synergistically enhanced the sensitivity of ...
http://cancerdiscovery.aacrjournals.org/content/5/8/793.2
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北京大学医学部机构知识库(IR@PKUHSC): Embelin derivatives and their anticancer activity through microtubule disassembly北京大学医学部机构知识库([email protected]): Embelin derivatives and their anticancer activity through microtubule disassembly
Biological activities of the 1,4-benzoquinone derivatives 5-O-ethylembelin (1) and 5-O-methylembelin (2) were investigated. Both of them showed anti proliferative activity against a panel of human tumor cell lines upon comparison to normal marsupial kidney cells (PtK2). They arrested HL-60 cells in the G(0)/G(1) phase of the cell cycle in a dose- and time-dependent manner. In HeLa cells, exposure to 100 mu M of 1 or 2 for 6 h induced a complete disassembly of the microtubule network and an increased number of cells blocked in mitotic stages. Treatment with 10 mu M of 1 and 2 for 24 h induced apoptosis in HL-60 cells. This evidence suggests that both 1 and 2 are promising novel antimitotic and anticancer molecules targeting microtubular proteins. ...
http://ir.bjmu.edu.cn/handle/400002259/62601
Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics | CU...Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics | CU...
Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics Journal Article ...
https://experts.colorado.edu/display/pubid_50726
Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by . . . by David A. Davis, Sarah H....Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by . . . by David A. Davis, Sarah H....
Abstract Background Kinesin spindle proteins (KSP) are motor proteins that play an essential role in mitotic spindle formation. HsEg5, a KSP, is responsible for the formation of the bipolar spindle, which is critical for proper cell division during mitosis. The function of HsEg5 provides a novel target for the manipulation of the cell cycle and the induction of apoptosis. SB715992, an experimental KSP inhibitor, has been shown to perturb bipolar spindle formation, thus making it an excellent candidate for anti-cancer agent. Our major objective was a) to investigate the cell growth inhibitory effects of SB715992 on PC-3 human prostate cancer cell line, b) to investigate whether the growth inhibitory effects of SB715992 could be enhanced when combined with genistein, a naturally occurring isoflavone and, c) to determine gene expression profile to establish molecular mechanism of action of SB715992. Methods PC-3 cells were treated with varying concentration of SB715992, 30 μM of genistein, and SB715992
https://digitalcommons.wayne.edu/biomedcentral/199/
Intraluminal Prostheses Having Polymeric Material with Selectively Modified Crystallinity and Methods of Making Same -...Intraluminal Prostheses Having Polymeric Material with Selectively Modified Crystallinity and Methods of Making Same -...
0038] Pharmacological agents suitable for inclusion in prosthesis materials and/or coatings, according to embodiments of the present invention include, but are not limited to, drugs and other biologically active materials, and may be intended to perform a variety of functions, including, but not limited to: anti-cancer treatment (e.g., Resan), anti-clotting or anti-platelet formation, the prevention of smooth muscle cell growth and migration on a vessel wall, and cell cycle inhibitors. Pharmacological agentsmay include antineoplastics, antimitotics, antiinflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, immunosuppressives, and antiallergic substances as well as combinations thereof. Examples of such antineoplastics and/or antimitotics include paclitaxel (e.g., TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.), docetaxel (e.g., TAXOTERE® from Aventis S. A., Frankfurt, Germany) methotrexate, azathioprine, vincristine, ...
http://www.patentsencyclopedia.com/app/20110169198
antimitotic drugsantimitotic drugs
Drugs that block mitosis; the term is often used of those which cause metaphase arrest such as colchicine and the vinca alkaloids. Many anti tumour drugs are antimitotic, blocking proliferation rather than being cytotoxic
http://en.academic.ru/dic.nsf/en_molecular_biology/467/antimitotic
Amikhelline - WikipediaAmikhelline - Wikipedia
Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase. Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales. 1985;179(3):331-9. PMID 2417673 Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. Biochimie. 1973;55(11):1415-20. PMID 4364376 Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. Biochimie. 1976;58(6):689-95. PMID ...
https://en.wikipedia.org/wiki/Amikhelline
How do anti-mitotic drugs kill cancer cells? | Journal of Cell ScienceHow do anti-mitotic drugs kill cancer cells? | Journal of Cell Science
Although the results of recent cell culture studies have been highly informative, they will not be of great use if they bear no relation to events in an in vivo context. Significantly, a pair of studies that investigated the effect of taxanes on several mouse tumour models also observed wide variation in the response. Tumour regression that was induced by taxane treatment varied widely, and the mitotic index of cells within the tumour did not correlate with either cell death or tumour regression (Milross et al., 1996; Schimming et al., 1999). Similar observations were made in a highly informative clinical study. Eleven women that received neoadjuvant taxol treatment for non-metastatic breast cancer were followed and, at regular intervals post-treatment, biopsies and mammograms were used to determine the mitotic index, apoptotic index and tumour size (Symmans et al., 2000). The authors observed a wide variation in both the mitotic and apoptotic index in response to the drug, with no correlation ...
https://jcs.biologists.org/content/122/15/2579
Leukemia Treatment - Cancer EffectsLeukemia Treatment - Cancer Effects
In general, your oncologist will consider your age and type of leukemia you have to recommend you an appropriate treatment. Leukemia treatment is generally less intensive in patients aged over 60 years.. Chemotherapy. Chemotherapy in the treatment of chronic lymphocytic leukemia is, in many cases, unnecessary. Mild chemotherapy can be used to reduce the number of white blood cells and reduce the size of lymph nodes and spleen.. Treatment of acute, myeloid and lymphoid leukemia is based on Anti-mitotic Drugs (anti-mitotic chemotherapy); certain substances that are often used in the chemotherapy of these types of leukemia include vincristine and vinblastine. Those medications inhibit mitotic cellular division, and prevent the damage of the disease in the body. However, the treatment destroys not only the tumor cells but also the normal cells in your bone marrow, which makes you susceptible to infections, bleeding and anemia. A bone marrow transplant may also be considered. Sometimes the therapy ...
http://cancereffects.com/leukemia-treatment/
BCL-2 hypermethylation is a potential biomarker of sensitivity to anti-mitotic chemotherapy in endocrine-resistant breast...BCL-2 hypermethylation is a potential biomarker of sensitivity to anti-mitotic chemotherapy in endocrine-resistant breast...
Overexpression of the anti-apoptotic factor, BCL-2, is a frequent feature of malignant disease and is commonly associated with poor prognosis and resistance to conventional chemotherapy. In breast cancer, however, high BCL-2 expression is associated with favourable prognosis, estrogen receptor (ER) positivity and low tumour grade; whilst low expression is included in several molecular signatures associated with resistance to endocrine therapy. In the present study, we correlate BCL-2 expression and DNA methylation profiles in human breast cancer and in multiple cell models of acquired endocrine-resistance to determine whether BCL-2 hypermethylation could provide a useful biomarker of response to cytotoxic therapy. In human disease, diminished expression of BCL-2 was associated with hypermethylation of the second exon, in a region that overlapped a CpG island and an ER-binding site. Hypermethylation of this region, which occurred in 10% of primary tumours, provided a stronger predictor of patient
https://www.garvan.org.au/research/publications/11629
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Japanese)Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Japanese)
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Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Hindi)Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Hindi)
कैंसर के उपचार के लिए प्रतिरोध रोग प्रगति और मौत के लिए योगदान देता है । प्रतिरोध के यंत्रवत आधार का निर्धारण चिकित्सीय प्रतिक्रिया में ...
https://www.jove.com/v/56327?language=Hindi
Bcl-2 Proteins in Mechanism of Anti-mitotic Drug Action - Timothy ChambersBcl-2 Proteins in Mechanism of Anti-mitotic Drug Action - Timothy Chambers
Understanding the molecular mechanisms of action of antitumor agents is significant for advancing fundamental knowledge and for improvement in cancer treatment....
http://grantome.com/grant/NIH/R01-CA109821-10
Designated organic active ingredient containing (doai) > Heterocyclic carbon compounds containing a hetero ring having...Designated organic active ingredient containing (doai) > Heterocyclic carbon compounds containing a hetero ring having...
Name: Drug, bio-affecting and body treating compositions > Designated organic active ingredient containing (doai) > Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., o,s,se or te) or nitrogen as the only ring hetero atoms doai > Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms > Polycyclo ring system having the seven-membered hetero ring as one of the cyclos > Tricyclo ring system having the seven-membered hetero ring as one of the ...
http://www.patentgenius.com/class/514/220.html
The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early...The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early...
The Deacetylation Phosphorylation Regulation of the SIRT2-SMC1A Axis as a Mechanism of the Antimitotic Catastrophe in Early Tumor Development Science Advances
https://thoriumbaby.com/the-deacetylation-phosphorylation-regulation-of-sirt2-smc1a-axis-as-a-mechanism-of-antimitotic-catastrophe-in-early-tumorigenesis-science-advances/
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase | PNASStructural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase | PNAS
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. The discovery of specific inhibitors of CDKs such as polyhydroxylated flavones has opened the way to investigation and design of antimitotic compounds. A novel flavone, (-)-cis-5,7-dihydroxyphenyl-8-[4-(3-hydroxy-1-methyl)piperidinyl] -4H-1-benzopyran-4-one hydrochloride hemihydrate (L868276), is a potent inhibitor of CDKs. A chlorinated form, flavopiridol, is currently in phase I clinical trials as a drug against breast tumors. We determined the crystal structure of a complex between CDK2 and L868276 at 2.33 angstroms resolution and refined to an Rfactor 20.3%. The aromatic portion of the inhibitor binds to the adenine-binding pocket of CDK2, and the position of the phenyl group of the inhibitor enables the inhibitor to make contacts with the enzyme not observed in the ATP complex structure. The analysis of ...
https://www.pnas.org/content/93/7/2735?ijkey=b86da83b7ae4c3f179cf3f9b644ef62c975ff0e5&keytype2=tf_ipsecsha
Apoptosis in the absence of caspase 3Apoptosis in the absence of caspase 3
MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade. Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzi …
https://pubmed.ncbi.nlm.nih.gov/11641782/?dopt=Abstract
Metabolic therapies inhibit tumor growth in vivo and in silicoMetabolic therapies inhibit tumor growth in vivo and in silico
In the recent years, cancer research succeeded with sensitive detection methods, targeted drug delivery systems, and the identification of a large set of genes differently expressed. However, although most therapies are still based on antimitotic agents, which are causing wide secondary effects, the …
https://pubmed.ncbi.nlm.nih.gov/30816152/
Anti-Cancer Medicine Hetero Manufacturer, Supplier, ExporterAnti-Cancer Medicine Hetero Manufacturer, Supplier, Exporter
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Mitotic Cells Antibody (8B3G) [DyLight 488] (NBP1-97684G): Novus BiologicalsMitotic Cells Antibody (8B3G) [DyLight 488] (NBP1-97684G): Novus Biologicals
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Patent US6593321 - 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity - Google PatentsPatent US6593321 - 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity - Google Patents
The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.
http://www.google.com/patents/US6593321?dq=6,034,652
Hetero chromosomes Synonyms, Hetero chromosomes Antonyms | Thesaurus.comHetero chromosomes Synonyms, Hetero chromosomes Antonyms | Thesaurus.com
Synonyms for hetero chromosomes at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
http://www.thesaurus.com/browse/hetero%20chromosomes
Designated organic active ingredient containing (doai) > Heterocyclic carbon compounds containing a hetero ring having...Designated organic active ingredient containing (doai) > Heterocyclic carbon compounds containing a hetero ring having...
Description: Subject matter wherein the seven-membered hetero ring is attached directly or indirectly by nonionic bonding to an additional nitrogen-containing hetero ring ...
http://www.patentgenius.com/class/514/211.15.html
Research Articles (Physiology)Research Articles (Physiology)
BACKGROUND : Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in ...
https://repository.up.ac.za/handle/2263/1833
Dinitramine | AbcamDinitramine | Abcam
Buy Dinitramine (CAS 29091-05-2), a water soluble plant and parasite-selective antimitotic, microtubule disrupting agent. Join researchers using high quality…
http://www.abcam.com/dinitramine-ab145978.html
Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities<...Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities<...
TY - JOUR. T1 - Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities. AU - Robles, Andrew J.. AU - Peng, Jiangnan. AU - Hartley, Rachel M.. AU - Lee, Brigette. AU - Mooberry, Susan L.. PY - 2015/3/27. Y1 - 2015/3/27. N2 - A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known germacranolide sesquiterpene lactones, leucanthin-A (2), leucanthin-B (3), melampodin-A acetate (4), and 3α-hydroxyenhydrin (5). The chemical structure of 1 was elucidated by analysis of 1D and 2D NMR and mass spectrometric data. All compounds exhibited antiproliferative and cytotoxic efficacy against PC-3 and DU 145 prostate cancer cells, as well as HeLa cervical cancer cells, with IC50 values ranging from 0.18 to 9 μM. These compounds were effective in clonogenic assays and displayed high cellular persistence. They were also found to be capable of circumventing ...
https://researchexperts.utmb.edu/en/publications/melampodium-leucanthum-a-source-of-cytotoxic-sesquiterpenes-with-
ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and...ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and...
ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tu
http://cckinase.com/e_productshow/?440-ABT-751-ABT751-ABT-751-E7010-E-7010-E-7010-857447-92-8-440.html
Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.
Fisetin is a natural flavonol present in edible vegetables, fruits and wine at 2-160 microg/g concentrations and an ingredient in nutritional supplements with much higher concentrations. The compound has been reported to exert anticarcinogenic effects as well as antioxidant and anti-inflammatory activity via its ability to act as an inhibitor of cell proliferation and free radical scavenger, respectively. Our cell-based high-throughput screen for small molecules that override chemically induced mitotic arrest identified fisetin as an antimitotic compound. Fisetin rapidly compromised microtubule drug-induced mitotic block in a proteasome-dependent manner in several human cell lines. Moreover, in unperturbed human cancer cells fisetin caused premature initiation of chromosome segregation and exit from mitosis without normal cytokinesis. To understand the molecular mechanism behind these mitotic errors, we analyzed the consequences of fisetin treatment on the localization and phoshorylation of ...
http://vivo.mblwhoilibrary.org/display/publication39681
Vincristine News, ResearchVincristine News, Research
Vincristine is the active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent ...
https://www.news-medical.net/?tag=/Vincristine
Plus itPlus it
Polyamine analogues have been shown to have antitumor activity as single agents in multiple experimental model systems (7, 8, 9, 10, 11, 12, 13, 14) . Their ability to modulate response to chemotherapeutic agents is worthy of study. This study addressed the activity of two polyamine analogues, CPENSpm and CHENSpm, in combination with multiple chemotherapeutic agents in breast cancer cell lines. The chemotherapeutic agents used were selected because they: (a) have antitumor activity in breast cancer; (b) are currently in use in the treatment of breast cancer; and (c) represent a broad spectrum of mechanisms of action. They include alkylating agents (4HC), topoisomerase II inhibitors (doxorubicin), antimetabolites (5-FU and FdURd), antimitotic agents (vinorelbine, paclitaxel, and docetaxel), and the DNA-reactive agent, c-DDP, which causes both intra- and interstrand DNA adducts.. Synergistic combinations were identified using one or both of the polyamine analogues in all of the cell lines ...
http://clincancerres.aacrjournals.org/content/7/2/391
Research and Markets: This Essential Report on Cancer Drug Resistance is Available Now. - Free Online LibraryResearch and Markets: This Essential Report on Cancer Drug Resistance is Available Now. - Free Online Library
Free Online Library: Research and Markets: This Essential Report on Cancer Drug Resistance is Available Now. by Business Wire; Business, international Antimitotic agents Market research Reports Antineoplastic agents Care and treatment Drug therapy Cancer research Cancer treatment Drug resistance in microorganisms Microbial drug resistance Oncology, Experimental Pharmaceutical industry
https://www.thefreelibrary.com/Research+and+Markets%3A+This+Essential+Report+on+Cancer+Drug+Resistance+...-a0185206196
Plus itPlus it
The antimitotic agent docetaxel is the standard therapy for patients with hormone-refractory prostate cancer (HRPC), but fatal resistance ultimately develops despite an initial response. Domingo-Domenech and colleagues generated docetaxel-resistant HRPC cell lines to gain insight into the underlying resistance mechanisms and identify potential targets to prevent the development of docetaxel resistance in HRPC. Docetaxel-resistant cells showed downregulation of epithelial differentiation markers such as cytokeratins (CK) and a marked upregulation of developmental genes in the Notch and Hedgehog signaling pathways. To determine whether these observations had clinical relevance, the authors evaluated a panel of primary and metastatic prostate cancer samples and identified a small subpopulation of preexisting CK-negative cells with upregulated Notch and Hedgehog signaling in each tumor. Of note, these cells were more abundant in samples from patients with advanced disease and a higher percentage of ...
http://cancerdiscovery.aacrjournals.org/content/early/2012/09/18/2159-8290.CD-RW2012-159
Smiths Drugstore: Non drowsy benadryl generic pills!Smiths Drugstore: Non drowsy benadryl generic pills!
Mental health the nursing actions for additional health information joining a support group meetings here. Action your doctor within 20 hours possible cause blepharitis, inflammation of the following 4 categories: Alkylating agents, antimetabolites, antimitotics, and antibiotics may be required: Stress management development and enhancement of k+ and some other conditions. 5 basic to nursing, ed 3. Cv mosby, st. 4. Potential dysfunctional patterns: The potential for enhancing the intrinsic pacemaker exceeds that of 69 reports, the soleplaints included nausea, vomiting, hepatotoxicity, lactic acidosis in cancer patients with potentially serious adverse effects. *these values were determined in rat smooth muscle cells, secondary to prostate disease include hypersensitivity pneumonitis, medications with prolonged use can result from inhalation of heroin pyrolosate; body packing. Some xenobiotics suppress av nodal conduction cause marked lengthening of night sleep and wakefulness that be saturated ...
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ePrint Order Form | Bentham ScienceePrint Order Form | Bentham Science
Article Title : Targeting Urokinase and the Transferrin Receptor with Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death and Reduces Tumor ...
http://www.eurekaselect.com/eprint_order/MTJ8xfDF08fDac2MdDg0E
Publications | Page 7 | Heidelberg Collaboratory for Image Processing (HCI)Publications | Page 7 | Heidelberg Collaboratory for Image Processing (HCI)
Steen, J A J, Steen, H, Georgi, A, Parker, K C, Springer, M, Kirchner, M, Hamprecht, F A and Kirschner, M W (2008). Different Phosphorylation States of the Anaphase Promoting Complex in Response to Anti-Mitotic Drugs: A Quantitative Proteomic Analysis. Proceedings of the National Academy of Sciences. 105 6069-6074 ...
https://hci.iwr.uni-heidelberg.de/biblio?page=6&%3Bamp%3Bf%5Bauthor%5D=3328&%3Bf%5Bauthor%5D=2335&f%5Bauthor%5D=2323&s=type&o=asc
Publications | Page 13 | Heidelberg Collaboratory for Image Processing (HCI)Publications | Page 13 | Heidelberg Collaboratory for Image Processing (HCI)
Steen, J A J, Steen, H, Georgi, A, Parker, K C, Springer, M, Kirchner, M, Hamprecht, F A and Kirschner, M W (2008). Different Phosphorylation States of the Anaphase Promoting Complex in Response to Anti-Mitotic Drugs: A Quantitative Proteomic Analysis. Proceedings of the National Academy of Sciences. 105 6069-6074 ...
https://hci.iwr.uni-heidelberg.de/biblio?page=12&%3Bamp%3Bf%5Bauthor%5D=3347&%3Bf%5Bauthor%5D=2186&f%5Bauthor%5D=2321&s=type&o=desc
Advanced Computational Methods for Biocomputing and BioimagingAdvanced Computational Methods for Biocomputing and Bioimaging
Computational models have been playing a significant role for the computer-based analysis of biological and biomedical data. Given the recent availability of genomic sequences and microarray gene expression data, there is an increasing demand for developing and applying advanced computational techniques for exploring these types of data such as functional interpretation of gene expression data, deciphering of how genes and proteins work together in pathways and networks, extracting and analysing phenotypic features of mitotic cells for high throughput screening of novel anti-mitotic drugs. Successful applications of advanced computational algorithms to solving modern life-science problems will make significant impacts on several important and promising issues related to genomic medicine, molecular imaging, and the scientific knowledge of the genetic basis of diseases ...
https://www.novapublishers.com/catalog/product_info.php?products_id=4567
Practical Fragments: Ninth Annual Fragment-based Drug Discovery Meeting, Part 2Practical Fragments: Ninth Annual Fragment-based Drug Discovery Meeting, Part 2
Jim Wells (UCSF) gave a magisterial keynote address that emphasized how useful fragments can be for tackling difficult targets such as protein-protein interactions (PPIs). In fact, many of the talks in the protein-protein interaction track relied on fragments. Thats not to say its easy. Rod Hubbard (University of York and Vernalis) emphasized that advancing fragments to leads against such targets can take a long time and often requires patience that strains the management of many organizations. Fragment hits against PPIs usually have lower ligand efficiencies (0.23-0.25 kcal/mol/HA if youre lucky), and improving potency can be a bear. Rhian Holvey (University of Cambridge) presented a nice example of how she was able to find millimolar fragments that bind to the anti-mitotic target TPX2, potentially blocking its interaction with importin-alpha, but even structural information was not enough to get to potent inhibitors ...
http://practicalfragments.blogspot.com/2014/04/ninth-annual-fragment-based-drug.html
Indian Patents. 220861:A SUSPENSION OF NANOPARTICULATES OF AN ANTIMITOTIC DRUGIndian Patents. 220861:A SUSPENSION OF NANOPARTICULATES OF AN ANTIMITOTIC DRUG
Numerous compounds are known which are useful in the prevention and treatment of various types of cancer. In order to effectively deliver these compounds by intravenous administration, it is generally preferred that the compounds be in solution to avoid or reduce the risk of blood clotting or other adverse effects that could result if the compounds were delivered in particulate form. Unfortunately, many of these compounds have poor solubility in water, the preferred solvent, and must be delivered using solvents which can cause adverse patient reactions that must in turn be prevented or controlled through the administration of other compounds. For example, paclitaxel is a known inhibitor of cell division or mitosis and is widely used in the treatment of ovarian, breast, lung, esophageal, bladder, head and neck cancers. Paclitaxel is a natural product originally purified from the bark of yew trees, but now obtained by semisynthesis from 10-desacetylbaccatin, a precursor purified from yew leaves. ...
http://www.allindianpatents.com/patents/220861-a-suspension-of-nanoparticulates-of-an-antimitotic-drug
Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. - PubMed - NCBIMechanism of action of tubulysin, an antimitotic peptide from myxobacteria. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/16491500?dopt=Abstract
Lypex TZ Injection : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Hetero Drugs Ltd | vial of 1...Lypex TZ Injection : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Hetero Drugs Ltd | vial of 1...
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Ampilin 1gm Injection : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Hetero Drugs Ltd | vial...Ampilin 1gm Injection : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Hetero Drugs Ltd | vial...
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India export data of HeteroIndia export data of Hetero
select /*+ index(customs_tariff_heading,description_of_goods,port_of_destination,country_code,indian_Port,unit_quantity_code,file_date) */ SQL_CALC_FOUND_ROWS id,port_of_destination as port_of_destination,description_of_goods,customs_tariff_heading,quantity,unit_quantity_code,country_code,value_of_goods_in_rupees,indian_Port,unit_value,date_format(file_date,%d-%b-%y) as date_time from eximpuls_export.export_master where 1=1 and match(description_of_goods)Against(+Hetero +Ltd IN BOOLEAN MODE) order by sort_date desc limit 50 offset ...
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Hetero Labs Ltd.Hetero Labs Ltd.
Founded in 2001, Hetero Labs Ltd. is a large organization in the pharmaceutical preparation companies industry located in Hyderabad, India. It generates $595 million in annual revenue.
http://www.imedez.com/pharmaceutical-companies/hetero-labs-ltd/
Advice Goddess BlogAdvice Goddess Blog
Purplepen -. It may well be true that everything else being equal, two hetero parents are prefferable to same sex parents. The juries still out, every study that I have seen thus far has been dubious at best. It will be a few more years before sample sizes can provide any definitive data. The only reasonable study thus far is out of Sweden, which really wouldnt apply to U.S. culture.. For the sake of argument and in the face of a dearth of reliable data, Ill capitulate that there are some advantages to two hetero parents raising children in the U.S. This doesnt change anything I said. This does not change the fact that the children of same sex couples, are just as deserving of the legal security that marriage provides their hetero parented counterparts. Nor does it mean that their parents relationship is any less valid than that of heteros. The only thing that is remotely in question, is whether their family unit is somehow inferior to that of their hetero parented counterparts, everything ...
http://www.advicegoddess.com/archives/2007/11/26/saying_i_dough.html
Act-Hib | MedicAct-Hib | Medic
Children with congenital or acquired immunodeficiency may be vaccinated, keeping in mind that, depending on the state of their immune system, their immune response will be lesser or greater. In children under immunosuppressive treatment (corticotherapy, antimitotic chemotherapy, etc.), it is recommended to postpone vaccination until the end of the treatment ...
https://medic.co.il/drug/act-hib/
THE PHOTOCHEMISTRY OF UNSATURATED SYSTEMS CONTAINING HETERO ATOMS OTHER THAN OXYGEN.THE PHOTOCHEMISTRY OF UNSATURATED SYSTEMS CONTAINING HETERO ATOMS OTHER THAN OXYGEN.
The report presents a summary of a study of the products and mechanisms of reactions wherein unsaturated systems containing nitrogen or sulfur are photolyzed. Included are studies of (1) the photochemical Beckmann rearrangement, (2) the general heteroatom transfer, (3) coumalin dimerization, and (4) the photolytic decomposition of beta-ketosulphones. (Author)(*PHOTOCHEMICAL REACTIONS
http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0637597
Accurate tuning of emission of GaInAsP/InP hetero structures in multiwafer gas-source molecular-beam epitaxy - Nokia Bell LabsAccurate tuning of emission of GaInAsP/InP hetero structures in multiwafer gas-source molecular-beam epitaxy - Nokia Bell Labs
Nokia sites use cookies to improve and personalize your experience and to display advertisements. The sites may also include cookies from third parties. By using this site, you consent to the use of cookies. Learn more ...
http://www.bell-labs.com/institute/publications/isi000228218300002/
Showing results for tags Mthfr. - ACN Latitudes ForumsShowing results for tags Mthfr. - ACN Latitudes Forums
So some of you may remember that my PANS daughter is compound hetero for 1298 and 677. My husband has one 1298 mutation. My other daughter has one 677 mutation. Of course, being the mom I was more concerned with everyone else and didnt even think to get myself checked! Well I was tested recently as part of a regular physical and it turns out I am homozygous for C677T... and my homacystine levels are already high. I was glad that I somewhat had an understanding of what it meant but now I am in supplement mode and trying to figure out what I have to do to bring my own levels down. Id love ...
https://latitudes.org/forums/tags/MTHFR/
Product InformationProduct Information
F. Hoffman La-Roche, Gilead Sciences Inc, Hetero Labs Ltd, Janssen Scientific Affairs, Lupin Pharmaceuticals, Merck & Co. Inc, Mylan ...
http://apregistry.com/product.aspx
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
A general redox‐neutral approach into the o‐,o′‐heteroatom‐linked N‐(hetero)aryl‐imidazole family of heteroaromatics has been developed. New types of ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:dipolar%20cycloaddition
PEMERKASA: Bantuan Tambahan RM500 Untuk B40, Penerima BPRPEMERKASA: Bantuan Tambahan RM500 Untuk B40, Penerima BPR
Perdana Menteri, Tan Sri Muhyiddin Yassin telah mengumumkan Bantuan Tambahan RM500 Untuk B40 dan Penerima BPR melalui program PEMERKASA.
https://jawatanmalaysia.net/pemerkasa-bantuan-rm500-b40/?replytocom=3225
PEMERKASA: Bantuan Tambahan RM500 Untuk B40, Penerima BPRPEMERKASA: Bantuan Tambahan RM500 Untuk B40, Penerima BPR
Perdana Menteri, Tan Sri Muhyiddin Yassin telah mengumumkan Bantuan Tambahan RM500 Untuk B40 dan Penerima BPR melalui program PEMERKASA.
https://jawatanmalaysia.net/pemerkasa-bantuan-rm500-b40/?replytocom=3157
PodophyllotoxinPodophyllotoxin
Additionally, antimitotic agents are not typically recommended during pregnancy. Additionally, it has not been determined if ... and antitumor agents. Podophyllotoxin derived antitumor agents include etoposide and teniposide. These drugs have been ... For example, ring A is not essential to antimitotic activity. Aromatization of ring C leads to loss of activity, possibly from ... Cragg GM, Kingston DG, Newman DJ (2011). Anticancer Agents from Natural Products, Second Edition (2 ed.). CRC Press. p. 97. ...
https://en.wikipedia.org/wiki/Podophyllotoxin
AmikhellineAmikhelline
Characterization of chromosomal aberrations induced in man by various antimitotic agents]". Comptes Rendus des Séances de la ... Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase. Turchini MF, Geneix A, Perissel ...
https://en.wikipedia.org/wiki/Amikhelline
DPP7DPP7
Roberts VJ, Gorenstein C (1990). "The effect of antimitotic agents on the intraneuronal distribution of lysosomes". Brain Res. ...
https://en.wikipedia.org/wiki/DPP7
FisetinFisetin
It can be found in many plants, where it serves as a colouring agent. It is also found in many fruits and vegetables, such as ... In vitro screening has identified fisetin as an antimitotic compound. Rodríguez-García C, Sánchez-Quesada C, Gaforio JJ (2019 ... In lab studies it also has been shown to be an anti-proliferative agent, interfering with the cell cycle in several ways. ... Fisetin has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced ...
https://en.wikipedia.org/wiki/Fisetin
RhizoxinRhizoxin
... is an antimitotic agent with anti-tumor activity. It is isolated from a pathogenic plant fungus (Rhizopus microsporus ... Anti-mitotic and anti-tubulin activity of new antitumor antibiotics, rhizoxin and its homologues". J. Antibiot. 40 (1): 66-72. ... 1986). "Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their ... 1999). "In vitro evaluation of antimicrotubule agents in human small-cell lung cancer cell lines". Anticancer Res. 19 (5B): ...
https://en.wikipedia.org/wiki/Rhizoxin
Plant tissue culturePlant tissue culture
This is usually achieved by application of antimitotic agents such as colchicine or oryzalin. As a tissue for transformation, ... Solid media are prepared from liquid media with the addition of a gelling agent, usually purified agar. The composition of the ... The hard surface of the seed is less permeable to the penetration of harsh surface sterilizing agents, such as hypochlorite, so ...
https://en.wikipedia.org/wiki/Plant_tissue_culture
History of cancer chemotherapyHistory of cancer chemotherapy
Paclitaxel (Taxol) was a novel antimitotic agent that promoted microtubule assembly. This agent proved difficult to synthesize ... Later, this agent would also be used to treat lung and ovarian cancers. Cisplatin, a platinum-based compound, was discovered by ... Notably, this agent, although developed by the NCI in partnership with Bristol-Myers Squibb, was exclusively marketed by BMS ( ... Most of these agents caused very severe nausea (termed chemotherapy-induced nausea and vomiting (CINV) in the literature) which ...
https://en.wikipedia.org/wiki/History_of_cancer_chemotherapy
Maryam Jafarkhani KermaniMaryam Jafarkhani Kermani
"Effect of different antimitotic agents on polyploid induction of anise hyssop (Agastache foeniculum L.) - PubAg". pubag.nal. ...
https://en.wikipedia.org/wiki/Maryam_Jafarkhani_Kermani
Monomethyl auristatin FMonomethyl auristatin F
... is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is ... Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin in ...
https://en.wikipedia.org/wiki/Monomethyl_auristatin_F
Monomethyl auristatin EMonomethyl auristatin E
... is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The ... These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as ... Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself ... It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called ...
https://en.wikipedia.org/wiki/Monomethyl_auristatin_E
Mature T-cell lymphomaMature T-cell lymphoma
This binding delivers monomethyl auristatin E (MMAE), an antimitotic agent that inhibits mitosis, and leads to anti-tumour ...
https://en.wikipedia.org/wiki/Mature_T-cell_lymphoma
Spindle poisonSpindle poison
Two specific families of antimitotic agents - vinca alkaloids and taxanes - interrupt the cell's division by the agitation of ... Agents that affect the motor protein kinesin are beginning to enter clinical trials. Another type, paclitaxel, acts by ... Even though numerous other spindle proteins exist that could be the target of novel chemotherapeutics, tubulin-binding agents ...
https://en.wikipedia.org/wiki/Spindle_poison
Enteropathy-associated T-cell lymphomaEnteropathy-associated T-cell lymphoma
Brentuximab vedotin is a chimeric monoclonal antibody that is complexed to the antimitotic agent, monomethyl auristatin E; the ... These IEL often exhibit natural killer and cytotoxic T-cell cell activation markers, contain various toxic agents (e.g. ... drug binds to the cell-membrane protein CD30 to deliver thereby the antimitotic aged into CD30-bearing target cells. This study ...
https://en.wikipedia.org/wiki/Enteropathy-associated_T-cell_lymphoma
NeoxalineNeoxaline
It is an antimitotic agent and shows weak inhibitory activity of blood platelet aggregation induced by simulation of the ... Ōmura Neoxaline an antimiotic agent Hirano, A.; Iwai, Y.; Masuma, R.; Tei, K.; Omura, S. (August 1979). "Neoxaline, a new ...
https://en.wikipedia.org/wiki/Neoxaline
VolasertibVolasertib
Common side effects as seen with other antimitotic agents such as vinca alkaloids and taxanes which include neuropathy, have ... investigating the effects of Volasertib both as a single agent and in combination with other agents in solid tumors and ... Volasertib can also cause cell death in cancer cells that have are no longer sensitive to existing anti-mitotic drugs such as ... protein being developed by Boehringer Ingelheim for use as an anti-cancer agent. Volasertib is the second in a novel class of ...
https://en.wikipedia.org/wiki/Volasertib
MoroidinMoroidin
... has no anti-mitotic activity. Other anti-tubulin agents used as chemotherapy agents have painful side effects known as ... Of this family, celogentin C is the most potent (IC50 0.8×10−6 M), and it is more potent than the anti-mitotic agent ... It also has demonstrated anti-mitotic properties, specifically by inhibition of tubulin polymerization. Anti-mitotic activity ... Agents that disrupt microtubules therefore inhibit mitosis through activation of this checkpoint. Moroidin and its related ...
https://en.wikipedia.org/wiki/Moroidin
Vinca alkaloidVinca alkaloid
... s are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant ... The newer semi-synthetic chemotherapeutic agent vinorelbine is used in the treatment of non-small-cell lung cancer and is not ... leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. ...
https://en.wikipedia.org/wiki/Vinca_alkaloid
Laucysteinamide ALaucysteinamide A
... the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells". ...
https://en.wikipedia.org/wiki/Laucysteinamide_A
Curacin ACuracin A
January 1998). "Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with ...
https://en.wikipedia.org/wiki/Curacin_A
2,5-Diketopiperazine2,5-Diketopiperazine
... verruculogen and the spiro-annulated spirotryprostatin B which represent a promising class of antimitotic arrest agents, to the ... Derivatives of cyclo(L-His-L-Pro) have been studied extensively to develop therapeutic agents for neurodegeneration. The 2,5- ... The unsaturated derivatives are illustrated by phenylahistin the anti-cancer microtubule binding agent, and the mycotoxin ... an antibacterial agent used as food additives to prevent diarrhea in animals while the thio derivatives such as the cytotoxic ...
https://en.wikipedia.org/wiki/2,5-Diketopiperazine
Endogenous regenerationEndogenous regeneration
... migrating neuroblasts and immature precursors are silenced with the anti-mitotic agent and astrocytes are infected with a ...
https://en.wikipedia.org/wiki/Endogenous_regeneration
List of MeSH codes (D27)List of MeSH codes (D27)
... antimitotic agents MeSH D27.505.954.248.150 - antineoplastic agents, alkylating MeSH D27.505.954.248.169 - antineoplastic ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)
Index of oncology articlesIndex of oncology articles
... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ... chemotherapeutic agent - chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker ...
https://en.wikipedia.org/wiki/Index_of_oncology_articles
Brentuximab vedotinBrentuximab vedotin
... and para-aminobenzylcarbamate spacers to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected ... These results demonstrated that single-agent brentuximab vedotin induced a 42% objective response rate and manageable safety ...
https://en.wikipedia.org/wiki/Brentuximab_vedotin
ChemotherapyChemotherapy
Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ...
https://en.wikipedia.org/wiki/Chemotherapeutics
ChemotherapyChemotherapy
Siddik ZH (2005). "Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ... of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic ... Alkylating agents will work at any point in the cell cycle and thus are known as cell cycle-independent drugs. For this reason ... Unlike alkylating agents, anti-metabolites are cell cycle dependent. This means that they only work during a specific part of ...
https://en.wikipedia.org/wiki/Chemotherapy
Small molecule drug conjugateSmall molecule drug conjugate
... as well as a companion imaging agent that is created by replacing the potent drug with an imaging agent. "Ultrasound First - ... The most advanced SMDC is vintafolide, a derivative of the anti-mitotic chemotherapy drug vinblastine which is chemically ...
https://en.wikipedia.org/wiki/Small_molecule_drug_conjugate
VinflunineVinflunine
As of 2016[update], vinflunine was the only commercially-approved agent in some countries for salvage therapy of urothelial ... Kruczynski A, Barret JM, Etiévant C, Colpaert F, Fahy J, Hill BT (March 1998). "Antimitotic and tubulin-interacting properties ...
https://en.wikipedia.org/wiki/Vinflunine
Estramustine phosphateEstramustine phosphate
EMP is a dual cytostatic and hence chemotherapeutic agent and a hormonal anticancer agent of the estrogen type. It is a prodrug ... In addition to its antimitotic actions, EMP has also been found to produce other cytostatic effects, including induction of ... or other more marked toxicity associated with such agents. In contrast to most other cytostatic agents, which often cause ... Antineoplastic agents related to EMP, although none of them were marketed, include alestramustine, atrimustine, cytestrol ...
https://en.wikipedia.org/wiki/Estramustine_phosphate
EribulinEribulin
"Anticancer Agent Halaven Approved For Treatment Of Locally Advanced Or Metastatic Breast Cancer In China" (Press release). ... Kawano, S; Asano, M; Adachi, Y; Matsui, J (2016). "Antimitotic and Non-mitotic Effects of Eribulin Mesilate in Soft Tissue ... "U.S. FDA Approves Eisai's Anticancer Agent Halaven For The Treatment Of Advanced Liposarcoma" (Press release). Eisai Co., Ltd. ... In addition to its cytotoxic, antimitotic-based mechanisms, preclinical studies in human breast cancer models have shown that ...
https://en.wikipedia.org/wiki/Eribulin
Vinca alkaloidVinca alkaloid
... s are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant ... leurosine and the chemotherapy agents vinblastine[3] and vincristine,[4] all of which can be obtained from the plant.[5][6][7][ ... 8] The newer semi-synthetic chemotherapeutic agent vinorelbine is used in the treatment of non-small-cell lung cancer[7][9] and ...
https://en.wikipedia.org/wiki/Vinca_alkaloids
Aspergillus fumigatusAspergillus fumigatus
"Antimicrobial Agents and Chemotherapy. 54 (6): 2425-30. doi:10.1128/AAC.01599-09. PMC 2876375. PMID 20385860.. ... When the fermentation broth of A. fumigatus was screened, a number of indolic alkaloids with antimitotic properties were ...
https://en.wikipedia.org/wiki/Aspergillus_fumigatus
HalichondriaHalichondria
"The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth". ... Anticancer agents from natural products. Washington, DC: Taylor & Francis. ISBN 978-0-8493-1863-4. OCLC 57169963. Hirata, ...
https://en.wikipedia.org/wiki/Halichondria
Recombinant AAV mediated genome engineeringRecombinant AAV mediated genome engineering
2010 The use of 'X-MAN' mutant PI3CA increases the expression of individual tubulin isoforms and promoted resistance to anti-mitotic ... Carroll D (November 2008). "Progress and prospects: zinc-finger nucleases as gene therapy agents". Gene Ther. 15 (22): 1463-8. ...
https://en.wikipedia.org/wiki/Recombinant_AAV_mediated_genome_engineering
Gold nanoparticles in chemotherapyGold nanoparticles in chemotherapy
By acting as a contrast agent and injected into cancerous tumor cells, it would result in a higher dose of the cancerous tissue ... Docetaxel is packed into PEGylated gold nanoparticles Docetaxel is an anti-mitotic chemotherapy medicine which showing great ... Another way in which AuNPs can be used in cancer therapy is as agents for targeted drug delivery. Research shows that AuNPs can ... Jain, S; Hirst, D G; O'Sullivan, J M (2012-02-01). "Gold nanoparticles as novel agents for cancer therapy". The British Journal ...
https://en.wikipedia.org/wiki/Gold_nanoparticles_in_chemotherapy
Narcissus (plant)Narcissus (plant)
The bulbs of N. poeticus contain the antineoplastic agent narciclasine. This usage is also found in later Arabian, North ... antimitotic, antiplatelet, hypotensive, emetic, acetylcholine esterase inhibitory, antifertility, antinociceptive, chronotropic ... Pettit, GR; Cragg, GM; Singh, SB; Duke, JA; Doubek, DL (1990). "Antineoplastic agents, 162. Zephyranthes candida". Journal of ... "Antineoplastic Agents. 587. Isolation and Structure of 3-Epipancratistatin from Narcissus cv. Ice Follies". Journal of Natural ...
https://en.wikipedia.org/wiki/Narcissus_(plant)
EpothiloneEpothilone
Agents Chemother. 46 (9): 2772-8. doi:10.1128/AAC.46.9.2772-2778.2002. PMC 127399. PMID 12183227. Muhlradt, P.F.; Sasse, F. ( ... At the higher antimitotic concentrations, paclitaxel appears to act by suppressing microtubule detachment from centrosomes, a ... Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and ... EMEA/602569/2008 Ojima, I.; Vite, G.D.; Altmann, K.H.; 2001 Anticancer Agents: Frontiers in Cancer Chemotherapy. American ...
https://en.wikipedia.org/wiki/Epothilone
Search of: Breast Ductal Carcinoma | Antimitotic Agents - List Results - ClinicalTrials.govSearch of: 'Breast Ductal Carcinoma' | 'Antimitotic Agents' - List Results - ClinicalTrials.gov
14 Studies found for: Breast Ductal Carcinoma , Antimitotic Agents. Also searched for Ductal breast carcinoma, Antimitotic ...
https://clinicaltrials.gov/ct2/results?cond=%22Breast+Ductal+Carcinoma%22&intr=%22Antimitotic+Agents%22
Definition of antimitotic agent - NCI Dictionary of Cancer Terms - National Cancer InstituteDefinition of antimitotic agent - NCI Dictionary of Cancer Terms - National Cancer Institute
antimitotic agent listen (AN-tee-my-TAH-tik AY-jent) A type of drug that blocks cell growth by stopping mitosis (cell division ...
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/antimitotic-agent
Antimitotic agent | definition of antimitotic agent by Medical dictionaryAntimitotic agent | definition of antimitotic agent by Medical dictionary
... antimitotic agent explanation free. What is antimitotic agent? Meaning of antimitotic agent medical term. What does antimitotic ... Looking for online definition of antimitotic agent in the Medical Dictionary? ... antimitotic agent. Also found in: Dictionary, Encyclopedia. antimitotic agent. Oncology. An agent that inhibits cancer growth ... antimitotic agent. Antimicrotubule agent, mitotic inhibitor Oncology An agent that inhibits cancer growth by stopping cell ...
https://medical-dictionary.thefreedictionary.com/antimitotic+agent
Disorazole C1: A potent antimitotic agent that induces premature senescence | Cancer ResearchDisorazole C1: A potent antimitotic agent that induces premature senescence | Cancer Research
Disorazole C1: A potent antimitotic agent that induces premature senescence Marni Brisson, Bethany Petrik, Thomas Graham, ... Disorazole C1: A potent antimitotic agent that induces premature senescence Marni Brisson, Bethany Petrik, Thomas Graham, ... Disorazole C1: A potent antimitotic agent that induces premature senescence Marni Brisson, Bethany Petrik, Thomas Graham, ... Disorazole C1: A potent antimitotic agent that induces premature senescence Message Subject (Your Name) has forwarded a page to ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/1219
Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents. - PubMed - NCBIOncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents. - PubMed - NCBI
Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.. Perera D1, ... the bottom 50 MYC-expressing lines (MYC low) treated with the indicated anti-mitotic agents. Data was obtained from the ... Cell death elicited by anti-mitotic agents in KRASG12D-expressing HeLa cells is mediated by MYC and BCL-XL. ... These anomalies are accompanied by increased sensitivity to anti-mitotic agents, a phenotype dependent on the transcription ...
https://www.ncbi.nlm.nih.gov/pubmed/27412232
Nerve Growth Factor (NGF)-Mediated Protection of Neural Crest Cells from Antimitotic Agent-Induced Apoptosis: The Role of the...Nerve Growth Factor (NGF)-Mediated Protection of Neural Crest Cells from Antimitotic Agent-Induced Apoptosis: The Role of the...
Effects of NGF (42 nm) on antimitotic agent-induced human neuroblastoma cell death. A, SH-SY5Y cells were pretreated with NGF ... Effects of p75- and trkA-selective mutant NGF species (4.2 nm) on antimitotic agent-induced SH-SY5Y cell death. Mutant NGF ... The antimitotic agent neocarzinostatin (NCS) was obtained from Kayaku Pharmaceuticals (Tokyo, Japan). NCS was stored in powder ... Effects of antibody 9651 (1:1000) on the protective effects of NGF (42 nm) in antimitotic agent-treated SH-SY5Y cells. Antibody ...
http://www.jneurosci.org/content/16/12/3895
Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. |...Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. |...
Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents.. ... Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. ... Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. [abstract]. In: ... Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/2475
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Hindi)Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Hindi)
कैंसर के उपचार के लिए प्रतिरोध रोग प्रगति और मौत के लिए योगदान देता है । प्रतिरोध के यंत्रवत आधार का निर्धारण चिकित्सीय प्रतिक्रिया में ...
https://www.jove.com/v/56327?language=Hindi
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Japanese)Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel | Protocol (Translated to Japanese)
がん治療への抵抗は、病気の進行と死亡に貢献します。抵抗
https://www.jove.com/v/56327?language=Japanese
Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity | 10.1007/s11030...Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity | 10.1007/s11030...
"Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation, Molecular Diversity" on DeepDyve, the ... Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation. Novel antimitotic agents related to ... Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation. Zefirova, Olga; Nurieva, Evgeniya; ... Three series of antimitotic agents related to tubuloclustin were designed and synthesized in order to enhance the molecular ...
https://www.deepdyve.com/lp/springer_journal/novel-antimitotic-agents-related-to-tubuloclustin-synthesis-and-jfH0w65NY0
JCDR - Antimitotic agent, Autologous blood, Conjunctival autograft, Pterygium surgeryJCDR - Antimitotic agent, Autologous blood, Conjunctival autograft, Pterygium surgery
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2020&month=September&volume=14&issue=9&page=NC01-NC04&id=13926
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents - Publikationsserver der Universität RegensburgAroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents - Publikationsserver der Universität Regensburg
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorganic & Medicinal Chemistry 16 (12), S. ... In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of ... In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of ...
https://epub.uni-regensburg.de/4787/
Patent US6593321 - 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity - Google PatentsPatent US6593321 - 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity - Google Patents
... and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents ... Estrogenic compounds as anti-mitotic agents. US6051726. Mar 13, 1997. Apr 18, 2000. Pharm-Eco Laboratories, Inc.. Synthesis of ... Estrogenic compounds as anti-mitotic agents. US20050014737 *. May 28, 2004. Jan 20, 2005. Agoston Gregory E.. Antiangiogenic ... Estrogenic compounds as anti-mitotic agents. US5892069. Apr 25, 1997. Apr 6, 1999. The Childrens Medical Center Corporation. ...
http://www.google.com/patents/US6593321?dq=6,034,652
Mannidex - Antimitotic agent, Antineoplastic Agents, Phytogenic, Keratolytic AgentsMannidex - Antimitotic agent, Antineoplastic Agents, Phytogenic, Keratolytic Agents
Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas ...
http://pharmacycode.com/Mannidex.html
BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer...BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast Cancer...
Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 2007;7:107-17. ... Effects of antimitotic agents on endocrine-resistant cell lines. Because treatment options are limited in endocrine-resistant ... 5A). TAMR-BCL-2 cells were significantly less responsive to all antimitotic agents compared with empty vector-transduced TAMR ... The reduction of BCL-2 expression in endocrine-resistant cells lowered their apoptotic threshold to antimitotic agents: ...
https://mct.aacrjournals.org/content/12/9/1874
Emergency Response Safety and Health Database: Glossary | NIOSH | CDCEmergency Response Safety and Health Database: Glossary | NIOSH | CDC
Antimitotic agent. An agent that prevents or interferes with cell division (mitosis).. ... A chemical agent or drug used in the treatment of disease; chemotherapeutic agents are selectively toxic to the causative agent ... Nettle agent. An agent that causes severe irritation to the skin and mucous membranes, as well as pain; also called urticant. ( ... An agent that causes severe irritation to the skin and mucous membranes, as well as pain; also called nettle agent.. ...
https://www.cdc.gov/niosh/ershdb/glossary.html
Words to Know | Living Beyond Breast CancerWords to Know | Living Beyond Breast Cancer
antimitotic agent. A type of medicine used to treat cancer that blocks cell growth by stopping mitosis (cell division). Also ... alkylating agent. A type of medicine used in cancer treatment. It interferes with cell DNA and blocks cancer cell growth. ... agent study. In cancer prevention, a clinical trial that studies whether taking certain medicines, vitamins, minerals or food ... Examples of agent studies include clinical trials for tamoxifen and letrozole, as well as lifestyle changes such as diet. ...
https://lbbc.org/learn/basics/words-to-know?name=%5Ea&items_per_page=All
Mitosis is not a key target of microtubule agents in patient tumors. - PubMed - NCBIMitosis is not a key target of microtubule agents in patient tumors. - PubMed - NCBI
Antimitotic Agents. Grant support. *ImNIH/Intramural NIH HHS/United States. LinkOut - more resources. Full Text Sources. * ... Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-targeting agents (MTAs) have a ... Mitosis is not a key target of microtubule agents in patient tumors.. Komlodi-Pasztor E1, Sackett D, Wilkerson J, Fojo T. ...
https://www.ncbi.nlm.nih.gov/pubmed/21283127?dopt=Abstract
HSE: New and expectant mothers - FAQsHSE: New and expectant mothers - FAQs
... chemical or biological agents). Any risks identified must be included and managed as part of the general workplace risk ... biological or chemical agents. For example, your dexterity, agility, co-ordination, speed of movement and reach may be impaired ... Biological agents *Infectious diseases. Chemical agents. *Toxic chemicals *Mercury *Antimitotic (cytotoxic) drugs ...
https://www.hse.gov.uk/mothers/faqs.htm
Patente US20070128245 - Porous calcium phosphate bone material - Google PatentesPatente US20070128245 - Porous calcium phosphate bone material - Google Patentes
In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected ... pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant ... alkylating agents, platinum agents, antimetabolites, topoisomerase inhibitors, antitumor antibiotics, antimitotic agents, ... By "effervescent agent" is meant an agent capable of producing bubbles of gas in a composition or an agent that emerges from a ...
http://www.google.es/patents/US20070128245
Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues<...Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues<...
Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential positron ... N2 - Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential ... AB - Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential ... abstract = "Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new ...
https://indiana.pure.elsevier.com/en/publications/synthesis-biodistribution-and-micro-pet-imaging-of-radiolabeled-a
Adriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients - Full Text View - ClinicalTrials.govAdriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients - Full Text View - ClinicalTrials.gov
Angiogenesis Modulating Agents. Growth Substances. Growth Inhibitors. Antineoplastic Agents, Phytogenic. Tubulin Modulators. ... Antineoplastic Agents. Topoisomerase II Inhibitors. Topoisomerase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ...
https://www.clinicaltrials.gov/ct2/show/NCT01056679
Two Regimens of Docetaxel in Treating Patients Who Have Not Received Chemotherapy For Unresectable Stage IIIB or Stage IV Non...Two Regimens of Docetaxel in Treating Patients Who Have Not Received Chemotherapy For Unresectable Stage IIIB or Stage IV Non...
Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of Pharmacological ...
https://clinicaltrials.gov/show/NCT00075374
Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer - Full Text View - ClinicalTrials.govRadiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer - Full Text View - ClinicalTrials.gov
Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular Mechanisms of Pharmacological ... Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm ...
https://www.clinicaltrials.gov/ct2/show?term=dry+mouth&fund=0&rank=51
Evaluation of the Safety and Tolerability of TAK-228 With TAK-117 and Paclitaxel in Advanced Solid Tumors - Full Text View -...Evaluation of the Safety and Tolerability of TAK-228 With TAK-117 and Paclitaxel in Advanced Solid Tumors - Full Text View -...
Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ... Use of anti-hypertensive agents to control hypertension before Cycle1 Day 1 is allowed. ...
https://www.clinicaltrials.gov/ct2/show/NCT03154294?map_cntry=US&map_state=US%3ASD&rank=14
Vinorelbine Tartrate Monograph for Professionals - Drugs.comVinorelbine Tartrate Monograph for Professionals - Drugs.com
Class: Antineoplastic Agents. - Vinca Alkaloids. - Antimitotic Agents. VA Class: AN900. Chemical Name: 3′,4′-Didehydro-4′-deoxy ... Antineoplastic agent; semisynthetic vinca alkaloid.1 4 21 b c. Uses for Vinorelbine Tartrate. Non-Small Cell Lung Cancer. Used ... Vinorelbine is an active antiproliferative agent in pretreated advanced breast cancer patients: a phase II study. J Clin Oncol ... Administer only under constant supervision by clinicians experienced in therapy with chemotherapeutic agents.1 b c ...
https://www.drugs.com/monograph/vinorelbine-tartrate.html
RCSB PDB - VLB Ligand Summary PageRCSB PDB - VLB Ligand Summary Page
Antimitotic Agents. *Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. *Antineoplastic and Immunomodulating Agents. * ... Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 ...
https://www.rcsb.org/ligand/VLB
Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL) (Conference) | ETDEWEBTotal body irradiation (TBI) of chronic lymphocytic leukemia (CLL) (Conference) | ETDEWEB
MAT.; LEUKEMIA; RADIOTHERAPY; ALKYLATING AGENTS; CHEMOTHERAPY; ENDOXAN; LYMPHOCYTES; PATIENTS; RADIATION DOSE UNITS; SURVIVAL ... TIME; WHOLE-BODY IRRADIATION; ANIMAL CELLS; ANTIMITOTIC DRUGS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; ...
https://www.osti.gov/etdeweb/biblio/7341189
RCSB PDB - EVP Ligand Summary PageRCSB PDB - EVP Ligand Summary Page
Antimitotic Agents. *Antineoplastic Agents. *Antineoplastic Agents, Phytogenic. *Antineoplastic and Immunomodulating Agents. * ... For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line ... Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins). It ...
http://www.rcsb.org/ligand/EVP
Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma<...Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma<...
Fingerprint Dive into the research topics of Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in ... Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma. International Journal of ... Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma. / Ferguson, Roisean E.; ... title = "Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma", ...
https://pure.hud.ac.uk/en/publications/intrinsic-chemotherapy-resistance-to-the-tubulin-binding-antimito
PaclitaxelChemotherapyType of antimitotic agentMitosisAnticancer agentsMicrotubuleVarious antimitoticSynthesisVinblastineCompoundsInhibitorsInhibitsAntitumorDRUGSSmall moleculeSubstancesMedicinal ChemistryAntiproliferativeApoptosisMitotic inhibitorBiologicalAbstractAnaloguesCancerClinicalEleutherobinColchicineBioavailableTubulin-bindinSensitivityAntineoplastic agentActivityDrugDisruptsTaxolExposureSuitableCellsTranscriptionInterferes
Paclitaxel6
  • Using a panel of 10 established renal cancer cell lines that have not been subjected to prior drug selection, the range of functional resistance phenotypes to the tubulin-binding agents paclitaxel, vinblastine, vincristine and patupilone (epothilone B, EPO906) was determined, together with expression of P-glycoprotein (PgP), multidrug resistance associated protein-2 (MRP2) and major vault protein (MVP) proteins. (hud.ac.uk)
  • We examined the mechanism of action of E7389 with purified microtubules and in living cells and found that, unlike antimitotic drugs including vinblastine and paclitaxel that suppress both the shortening and growth phases of microtubule dynamic instability, E7389 seems to work by an end-poisoning mechanism that results predominantly in inhibition of microtubule growth, but not shortening, in association with sequestration of tubulin into aggregates. (aacrjournals.org)
  • The antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. (unisi.it)
  • The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. (patents.com)
  • 4. The method of claim 3 , wherein the active agent is actinomycin D, paclitaxel, docetaxel, or rapamycin. (google.ca)
  • Although natural plant compounds such as resveratrol, curcumin, oridonin, gossypol, and paclitaxel have proven anticancer potential via autophagic signaling pathways, there is still a great need to find new natural compounds and investigate the underlying mechanisms, to facilitate their clinical use as potential anticancer agents through autophagic induction. (eurekaselect.com)
Chemotherapy7
  • We discuss these findings in terms of the variable efficacy of antimitotic drugs in cancer chemotherapy. (pnas.org)
  • Systemic chemotherapy forms the mainstay of cancer treatment, and agents that disrupt mitotic spindle assembly - so called `anti-mitotics' - are commonly used to treat a wide variety of cancers. (biologists.org)
  • Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations", Antimicrobial Agents and Chemotherapy, Dec. 1, 2001 American Society for Microbiology, Washington, DC, US-ISSN 0066-4804, vol. 45, No. 12, pp. 3293-3303. (patents.com)
  • However, due to the present limitations associated with standard chemotherapy, including side effects and acquired tumor resistance, there is an urgent need to discover new anticancer agents with improved therapeutic profiles. (mdpi.com)
  • The U.S. Food and Drug Administration today approved Truxima (rituximab-abbs) as the first biosimilar to Rituxan (rituximab) for the treatment of adult patients with CD20-positive, B-cell non-Hodgkin's lymphoma (NHL) to be used as a single agent or in combination with chemotherapy. (news-medical.net)
  • When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress. (news-medical.net)
  • chemotherapy: alkylating agents (cyclophosphamide = antimitotic) 75 to 100 % azoospermia after MOPP. (gfmer.ch)
Type of antimitotic agent2
  • It is a type of vinca alkaloid and a type of antimitotic agent. (news-medical.net)
  • It is a type of antimitotic agent. (lbbc.org)
Mitosis6
  • Antimicrotubule agent, mitotic inhibitor Oncology An agent that inhibits cancer growth by stopping cell division Pharmacology A drug that inhibits or blocks mitosis in a particular phase of the cell cycle-eg, metaphase arrest caused by colchicine and vinca alkaloids. (thefreedictionary.com)
  • Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents. (nih.gov)
  • An agent that prevents or interferes with cell division (mitosis). (cdc.gov)
  • Mitosis is not a key target of microtubule agents in patient tumors. (nih.gov)
  • Mitosis-specific agents have, to date, not been clinically successful. (nih.gov)
  • an agent that inhibits or disrupts mitosis. (absp.org.uk)
Anticancer agents10
  • Consistent with their FACS profiles, Immunocytochemistry and biochemical analysis revealed loss of intact microtubule structure, up regulation of cyclin B1 and aurora kinase B mRNA levels, corresponding to growth arrest in the G2/M. More importantly, our one pot synthesis strategy of unsymmetrical terphenyls of this structural class paves the way for design and development of novel anticancer agents. (aacrjournals.org)
  • As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. (mdpi.com)
  • The in silico and in vitro mechanistic evaluation indicated the potential of 16b as a lead for the development of novel anticancer agents against gastric cancer cells. (mdpi.com)
  • Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis-enabled by historic advances in methodology-has enormously expanded the scope of the possible. (routledge.com)
  • This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. (routledge.com)
  • 2019. Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents . (cardiff.ac.uk)
  • Using a pattern-matching computer program, COMPARE, correlative relationships were investigated between the arrays of P450 activities and the patterns of cytotoxicity exhibited by a large group of anticancer agents of proven or potential clinical utility. (aspetjournals.org)
  • Significant negative correlations between the patterns of P450-dependent 7-benzyloxyresorufin metabolism activity and cell line chemosensitivity were observed for 10 standard anticancer agents (including 6 alkylating agents) and 55 investigational compounds, suggesting a role for P450 metabolism in the inactivation of these agents. (aspetjournals.org)
  • P450 enzyme profiling may thus aid in interpreting the patterns of drug sensitivity and resistance in the NCI tumor cell panel, and may facilitate the identification of anticancer agents whose activity can be altered via cytochrome P450 metabolism. (aspetjournals.org)
  • The expression of P450 enzymes in tumor tissue can have a major impact on the responsiveness of tumors to cancer chemotherapeutic drugs, owing to the central role that these enzymes play in the metabolism of numerous clinically useful anticancer agents ( LeBlanc and Waxman, 1989 ). (aspetjournals.org)
Microtubule6
  • Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function. (google.com)
  • By contrast, microtubule-targeting agents (MTAs) have a long record of success, usually attributed to the induction of mitotic arrest. (nih.gov)
  • Antimitotic drugs can interact with tubulin and microtubules in a large number of distinct ways to disrupt microtubule polymerization and dynamics, and their distinct mechanisms may be important determinants of their specific anticancer activities ( 6 ). (aacrjournals.org)
  • The checkpoint machinery or related activities may be the indirect target of several anti-cancer therapies, including vinca alkaloids and taxanes, which are inhibitors of microtubule dynamics and are among the most effective anti-cancer agents ( 17 ⇓ ⇓ ⇓ - 21 ). (pnas.org)
  • Traditional anti-mitotic agents include the microtubule toxins such as taxol, other taxanes and the vinca alkaloids, all of which have proven successful in the clinic. (biologists.org)
  • Investigating the effects of these agents on microtubule dynamics ( Box 1 ) has revealed much about their mechanism of action. (biologists.org)
Various antimitotic2
  • Because the phosphorylation pattern provides insights into the complexity of regulation of the APC, we studied in detail the phosphorylation patterns at a single mitotic state of arrest generated by various antimitotic drugs. (pnas.org)
  • Despite the common state of arrest, the various antimitotic drug treatments resulted in differences in the phosphorylation patterns and phosphorylation stoichiometries. (pnas.org)
Synthesis4
  • Studies towards the asymmetric synthesis of novel antimitotic agents. (kidscan.org.uk)
  • 2018. Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents . (cardiff.ac.uk)
  • 2018. 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition . (cardiff.ac.uk)
  • 2017. Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis, and biological evaluation of new acyclic nucleoside protides . (cardiff.ac.uk)
Vinblastine1
  • Vinblastine is a vinca alkaloid antineoplastic agent. (rcsb.org)
Compounds3
  • Three series of antimitotic agents related to tubuloclustin were designed and synthesized in order to enhance the molecular diversity of "tubuloclustin-like" family of compounds. (deepdyve.com)
  • Arsenic and its compounds are used in insecticides, weed killers, solid-state doping agents, and various alloys. (cdc.gov)
  • The identification of antimitotic compounds in very low abundance and their high (0.5%) occurrence in natural extracts indicates that drug discovery efforts using this cell-based assay may lead to the identification of structurally novel antimitotic agents. (ubc.ca)
Inhibitors2
  • Also called antimitotic or antimicrotubule agents or mitotic inhibitors. (medindia.net)
  • Based on mode of action, payloads fall into three categories: antimitotic, DNA interacting, and transcription inhibitors. (drug-dev.com)
Inhibits1
Antitumor1
  • Podophyllotoxin derived antitumor agents include etoposide and teniposide. (wikipedia.org)
DRUGS2
  • An Aden carcinoma is involved in the majority of such cases, but in most cases it is actually the antimitotic agents that are at fault (mitomycin C, 5-fluorouracil, platinum-based drugs and bleomycin). (thefreedictionary.com)
  • The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (cancer.gov)
Small molecule1
  • Abstract 2475: Design and development of combretastatin based unsymmetrical terphenyls as small molecule antimitotic agents. (aacrjournals.org)
Substances1
  • The head-pieces can alternatively or additionally include a mechanical and/or electrical mechanism that provides one or more substances (e.g., medicine and/or other biological agent, etc.) and/or electrostimulation to a surgical site. (freepatentsonline.com)
Medicinal Chemistry1
  • Anti-Infective Agents publishes original research articles, full-length/mini reviews, drug clinical trial studies and guest edited issues on all the latest and outstanding developments on the medicinal chemistry, biology, pharmacology and use of anti-infective and anti-parasitic agents. (benthamscience.com)
Antiproliferative2
  • 12 . The implantable medical device of claim 1 , wherein the bioactive is an antiproliferative agent. (google.com.au)
  • 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer . (cardiff.ac.uk)
Apoptosis2
  • In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents. (jneurosci.org)
  • we have tested the necessity for and sufficiency of p75 binding of NGF for protection of neuroblastoma cells from antimitotic agent-induced apoptosis. (jneurosci.org)
Mitotic inhibitor1
  • A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent. (lbbc.org)
Biological2
  • Your workplace risk assessment should already consider any risks to female employees of childbearing age and, in particular, risks to new and expectant mothers (for example, from working conditions, or the use of physical, chemical or biological agents). (hse.gov.uk)
  • As part of that process, you should consider female employees of childbearing age, including new and expectant mothers, assessing the risks that may arise from any process, working condition or physical, biological or chemical agents. (hse.gov.uk)
Abstract1
  • abstract = "Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. (elsevier.com)
Analogues1
  • The assay was also used for quantitative comparison of the antimitotic activity of different analogues. (ubc.ca)
Cancer11
  • Also searched for Ductal breast carcinoma , Antimitotic , and Ductal breast cancer . (clinicaltrials.gov)
  • However, cancer cells develop resistance to several of these agents by altering drug transporters and signaling pathways. (aacrjournals.org)
  • Radiolabeled antimitotic agents [ 11 C]T138067 and [ 18 F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. (elsevier.com)
  • For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. (rcsb.org)
  • A ntineoplastic agents are widely used in cancer therapy because they can inhibit growth by disrupt- ing cell division and killing actively growing cells. (cdc.gov)
  • Dexrazoxane is a cardioprotective agent for use in conjunction with doxorubicin indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose. (drugbank.ca)
  • His major interests lie in the discovery of novel natural product agents for the treatment of cancer and AIDS, with an emphasis on multidisciplinary and international collaboration. (ebooks.com)
  • A medicine used together with other agents to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. (lbbc.org)
  • 2019. The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein-protein interaction . (cardiff.ac.uk)
  • In addition, NKTR-102 is also being tested as a single agent in a Phase 2 clinical trial in patients with second-line colorectal cancer and a Phase 1 clinical trial evaluating NKTR-102 in combination with 5-FU therapy. (prnewswire.com)
  • NKTR-105, a novel anti-mitotic agent, is in a Phase 1 clinical study in cancer patients with refractory solid tumors. (prnewswire.com)
Clinical4
  • The scope of the journal covers all pre-clinical and clinical research on antimicrobials, antibacterials, antiviral, antifungal, and antiparasitic agents. (benthamscience.com)
  • Check for active clinical trials using this agent. (cancer.gov)
  • As the first wave of these new agents enters clinical trails, much hope rests on their outcome. (biologists.org)
  • The case can be confirmed if laboratory testing was not performed because either a predominant amount of clinical and nonspecific laboratory evidence of a particular chemical was present or the etiology of the agent is known with 100% certainty. (cdc.gov)
Eleutherobin1
  • It revealed the importance of the C-11 to C-13 segment of the diterpene core of eleutherobin for its antimitotic activity. (ubc.ca)
Colchicine1
  • Determination of the antimitotic agents N-Desacetylcolchicine, demecocline and colchicine in serum and urine. (cdc.gov)
Bioavailable2
  • ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. (cckinase.com)
  • 857447-92-8 ) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. (cckinase.com)
Tubulin-bindin1
Sensitivity1
  • These anomalies are accompanied by increased sensitivity to anti-mitotic agents, a phenotype dependent on the transcription factor MYC and its downstream target anti-apoptotic protein BCL-XL. (nih.gov)
Antineoplastic agent1
  • Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins). (rcsb.org)
Activity2
  • This paper addresses the role of p75 in mediating the protective activity of NGF in neuroblastoma cells exposed to antimitotic agents. (jneurosci.org)
  • For example, ring A is not essential to antimitotic activity. (wikipedia.org)
Drug2
  • Because of these interactions it is considered an antimitotic drug. (wikipedia.org)
  • Amikhelline is an antimitotic drug. (wikipedia.org)
Disrupts1
  • This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (cckinase.com)
Taxol1
  • In this report, we have compared and contrasted the effects of these new agents in Taxol-sensitive and -resistant cell lines. (aacrjournals.org)
Exposure3
  • What health effects can be caused by exposure to antineoplastic agents? (cdc.gov)
  • How can I protect myself from exposure to antineoplastic agents? (cdc.gov)
  • The purpose of this brochure is to -- make you aware of the adverse health effects of antineoplastic agents, -- describe how you can be exposed to these agents, and -- provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. (cdc.gov)
Suitable1
  • 16$g(a),17$g(a)-Dialkylated steroids are prepared by reacting a 16$g(a)-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent. (sumobrain.com)
Cells3
  • Furthermore, the endonuclease inhibitor aurintricarboxylic acid abrogates the ultimate death of neural crest cells treated with antimitotic agents. (jneurosci.org)
  • Bioactive peptides, which can be used as cell-targeting or gene delivery agents, have been identified either by panning against purified receptors (19-24) or against intact cells or tissue samples, both in vitro and in vivo (25-33). (neb.com)
  • We actually have to use antimitotic agents to kill the non-neuronal cells. (protocol-online.org)
Transcription1
  • They act as antimitotic agents in the epidermis by influencing gene transcription resulting in inhibition of the immunological, inflammatory and proliferative processes of the disease [14-16]. (thefreedictionary.com)
Interferes1
  • Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. (drugbank.ca)