Antimicrobial Cationic Peptides
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Magainins
Polymyxin B
Defensins
Anti-Infective Agents
Cations
Microbial Sensitivity Tests
Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects. (1/2987)
Antibacterial glycopeptides isolated from insects are exciting bio-oligomers because they represent a family of compounds in which the structural and functional effects of incorporating short O-linked sugars to protein fragments can be studied. Additionally, their high activity in vitro warrants detailed further drug development efforts. Due to the limited availability of the isolated material, we used synthetic glycopeptides and some analogs to investigate the range of activity of drosocin and pyrrhocoricin. While addition of the Gal-GalNAc disaccharide to the natural mid-chain position generally increased the antibacterial activity of drosocin, pyrrhocoricin lacking sugar appeared to be more potent, with an IC50 against Escherichia coli D22 of 150 nM. Although glycosylated drosocin was active against E. coli in the low microM range in vitro, this peptide was completely inactive when injected into mice. The lack of in vivo activity of drosocin could be explained by the unusually high degradation rate of the peptides in mammalian sera. The early degradation products were inactive in vitro. In contrast, the peptides were considerably more stable in insect hemolymph, where their natural activity is manifested. (+info)Biological properties of structurally related alpha-helical cationic antimicrobial peptides. (2/2987)
A series of alpha-helical cationic antimicrobial peptide variants with small amino acid changes was designed. Alterations in the charge, hydrophobicity, or length of the variant peptides did not improve the antimicrobial activity, and there was no statistically significant correlation between any of these factors and the MIC for Pseudomonas aeruginosa, Escherichia coli, or Salmonella typhimurium. Individual peptides demonstrated synergy with conventional antibiotics against antibiotic-resistant strains of P. aeruginosa. The peptides varied considerably in the ability to bind E. coli O111:B4 lipopolysaccharide (LPS), and this correlated significantly with their antimicrobial activity and ability to block LPS-stimulated tumor necrosis factor and interleukin-6 production. In general, the peptides studied here demonstrated a broad range of activities, including antimicrobial, antiendotoxin, and enhancer activities. (+info)Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. (3/2987)
Positively charged antimicrobial peptides with membrane-damaging activity are produced by animals and humans as components of their innate immunity against bacterial infections and also by many bacteria to inhibit competing microorganisms. Staphylococcus aureus and Staphylococcus xylosus, which tolerate high concentrations of several antimicrobial peptides, were mutagenized to identify genes responsible for this insensitivity. Several mutants with increased sensitivity were obtained, which exhibited an altered structure of teichoic acids, major components of the Gram-positive cell wall. The mutant teichoic acids lacked D-alanine, as a result of which the cells carried an increased negative surface charge. The mutant cells bound fewer anionic, but more positively charged proteins. They were sensitive to human defensin HNP1-3, animal-derived protegrins, tachyplesins, and magainin II, and to the bacteria-derived peptides gallidermin and nisin. The mutated genes shared sequence similarity with the dlt genes involved in the transfer of D-alanine into teichoic acids from other Gram-positive bacteria. Wild-type strains bearing additional copies of the dlt operon produced teichoic acids with higher amounts of D-alanine esters, bound cationic proteins less effectively and were less sensitive to antimicrobial peptides. We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems. (+info)Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii. (4/2987)
The activity of recombinant bactericidal/permeability-increasing protein (rBPI21), alone or in combination with sulfadiazine, on the intracellular replication of Toxoplasma gondii was assessed in vitro and in mice with acute toxoplasmosis. rBPI21 markedly inhibited the intracellular growth of T. gondii in human foreskin fibroblasts (HFFs). Following 72 h of exposure, the 50% inhibitory concentration of rBPI21 for T. gondii was 2.6 micrograms/ml, whereas only slight cytotoxicity for HFF cells was observed at the concentrations tested. Subsequent mathematical analyses revealed that the combination of rBPI21 with sulfadiazine yielded slight to moderate synergistic effects against T. gondii in vitro. Infection of mice orally with C56 cysts or intraperitoneally (i.p.) with RH tachyzoites resulted in 100% mortality, whereas prolongation of the time to death or significant survival (P = 0.002) was noted for those animals treated with 5 to 20 mg of rBPI21 per kg of body weight per day. Treatment with rBPI21 in combination with sulfadiazine resulted in significant (P = 0.0001) survival of mice infected i.p. with tachyzoites but not of mice infected orally with T. gondii cysts. These results indicate that rBPI21 is active in vitro and in vivo against T. gondii and that its activity is significantly enhanced when it is used in combination with sulfadiazine. To our knowledge, this is the first report of the activity of rBPI21 against a protozoan parasite. (+info)In vitro antibacterial properties of pexiganan, an analog of magainin. (5/2987)
Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro broad-spectrum antibacterial activity when it was tested against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria. The pexiganan MIC at which 90% of isolates are inhibited (MIC90) was 32 micrograms/ml or less for Staphylococcus spp., Streptococcus spp., Enterococcus faecium, Corynebacterium spp., Pseudomonas spp., Acinetobacter spp., Stenotrophomonas spp., certain species of the family Enterobacteriaceae, Bacteroides spp., Peptostreptococcus spp., and Propionibacterium spp. Comparison of the MICs and minimum bactericidal concentrations (MBCs) of pexiganan for 143 isolates representing 32 species demonstrated that for 92% of the isolates tested, MBCs were the same or within 1 twofold difference of the MICs, consistent with a bactericidal mechanism of action. Killing curve analysis showed that pexiganan killed Pseudomonas aeruginosa rapidly, with 10(6) organisms/ml eliminated within 20 min of treatment with 16 micrograms of pexiganan per ml. No evidence of cross-resistance to a number of other antibiotic classes was observed, as determined by the equivalence of the MIC50s and the MIC90s of pexiganan for strains resistant to oxacillin, cefazolin, cefoxitin, imipenem, ofloxacin, ciprofloxacin, gentamicin, and clindamicin versus those for strains susceptible to these antimicrobial agents. Attempts to generate resistance in several bacterial species through repeated passage with subinhibitory concentrations of pexiganan were unsuccessful. In conclusion, pexiganan exhibits properties in vitro which make it an attractive candidate for development as a topical antimicrobial agent. (+info)A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. (6/2987)
We isolated SN-HLPf (Sambucus nigra hevein-like fruit protein), a hevein-like chitin-binding protein, from mature elderberry fruits. Cloning of the corresponding gene demonstrated that SN-HLPf is synthesized as a chimeric precursor consisting of an N-terminal chitin-binding domain corresponding to the mature elderberry protein and an unrelated C-terminal domain. Sequence comparisons indicated that the N-terminal domain of this precursor has high sequence similarity with the N-terminal domain of class I PR-4 (pathogenesis-related) proteins, whereas the C terminus is most closely related to that of class V chitinases. On the basis of these sequence homologies the gene encoding SN-HLPf can be considered a hybrid between a PR-4 and a class V chitinase gene. (+info)Endocytosis of heparin-binding protein (CAP37) is essential for the enhancement of lipopolysaccharide-induced TNF-alpha production in human monocytes. (7/2987)
Heparin-binding protein (HBP), also known as CAP37, is a proteolytically inactive serine protease homologue that is released from activated granulocytes. However, HBP is not a biologically inactive molecule but rather a multifunctional protein with properties that include the enhancement of LPS-induced TNF-alpha production from monocytes. We have previously demonstrated that HBP is internalized in monocytes. In the current study, we hypothesize that HBP is internalized in monocytes via endocytosis, and this internalization is an important mechanism by which HBP enhances LPS-induced TNF-alpha release. Using whole blood from healthy donors and flow cytometry, we found that colchicine (0.1-10 mM), cytochalasin D (1000 microM), NH4Cl (10-50 mM), and bafilomycin A1 (0.1-3 microM) significantly reduced the affinity of FITC-HBP for CD14-positive monocytes. Using isolated human monocytes and ELISA, we found that colchicine (0.1 mM), cytochalasin D (30 and 300 microM), NH4Cl (30 mM), and bafilomycin A1 (1 microM) significantly reduced the effect of HBP (10 microg/ml) to enhance LPS (10 ng/ml)-induced TNF-alpha release after 24 h. These findings demonstrate that internalization of HBP in monocytes is essential for the enhancement of LPS-induced TNF-alpha release. Transport of HBP to an activating compartment depends on intact F-actin polymerization and endosomal acidification, an important mechanism for endosomal protein sorting and trafficking. (+info)Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (8/2987)
Recent studies suggest that the gene defect in cystic fibrosis (CF) leads to a breach in innate immunity. We describe a novel genetic strategy for reversing the CF-specific defect of antimicrobial activity by transferring a gene encoding a secreted cathelicidin peptide antibiotic into the airway epithelium grown in a human bronchial xenograft model. The airway surface fluid (ASF) from CF xenografts failed to kill Pseudomonas aeruginosa or Staphylococcus aureus. Partial reconstitution of CF transmembrane conductance regulator expression after adenovirus-mediated gene transfer restored the antimicrobial activity of ASF from CF xenografts to normal levels. Exposure of CF xenografts to an adenovirus expressing the human cathelicidin LL-37/hCAP-18 increased levels of this peptide in the ASF three- to fourfold above the normal concentrations, which were equivalent in ASF from CF and normal xenografts before gene transfer. The increase of LL-37 was sufficient to restore bacterial killing to normal levels. The data presented describe an alternative genetic approach to the treatment of CF based on enhanced expression of an endogenous antimicrobial peptide and provide strong evidence that expression of antimicrobial peptides indeed protects against bacterial infection. (+info)Improvement of outer membrane-permeabilizing and lipopolysaccharide- binding activities of an antimicrobial cationic peptide by...
ANTIMICROBIAL POLYPEPTIDES - Patent application
Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37 | The Journal of...
The Human Host Defense Peptide LL-37 Induces Caspase-independent Apoptosis Via Apoptosis-Inducing Factor And Endonuclease G in...
Defensins and other antimicrobial peptides and proteins<...
A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. - Semantic Scholar
Cationic host defence peptides: multifaceted role in immune modulation and inflammation. - PubMed - NCBI
Patente WO1994018323A1 - Stable bactericidal/permeability-increasing protein products and ... - Google Patentes
Explore our research
Explore our research
Regulation of antimicrobial peptide gene expression by nutrients and byproducts of microbial metabolism
Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide - Soligenix
Pharmaceuticals | Free Full-Text | Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications | HTML
Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in | proLékaře.cz
Activity of antimicrobial peptides and 25-hydroxycholecalciferol in children with asthma - medexpert
Gamma AApeptides as Host Defense Peptide Mimics by Yaqiong Li
Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides
Dr Donald J Davidson | The University of Edinburgh
Using anti-biofilm peptides to treat antibiotic-resistant bacterial infections
Welcome to the APD3
Welcome to the APD3
中国科学院动物研究所机构知识库(CAS OpenIR): Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or...
Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. - PubMed - NCBI
Exploring the Activity Space of Multifaceted Host Defence Peptides | UBC Chemistry
Eduardo Cobo | Cobo Lab | Calgary | Cathelicidin | Host defense peptides
Next generation of de novo designed amphipathic α-helical antimicrobial peptides to treat the gram-negative pathogen,...
Indolicidin Stabilizes Duplex DNA and Prevents DNA Replication and Transcription - AAPPTEC
Antimicrobial peptides | DermNet NZ
Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs | GMR | Genetics and...
ARTICLES | Journal of Applied Physiology
Polymorphisms of candidate genes associated with meat quality and disease resistance in indigenous and exotic pig breeds of...
Antimicrobial peptides in action | Research | University of Groningen
High-Dose Vitamin D and Antimicrobial Peptide Expression in Lung Failure - Gregory Martin
Developmental switch of intestinal antimicrobial peptide expression | JEM
Versatile interactions of the antimicrobial peptide novispirin with detergents and lipids
- Aalborg Universitets...
Ebook Mammalian host defense peptides Download PDF EPUB FB2
DUGi: Ítem | Recercat - Antimicrobial peptide genes in Bacillus strains from plant environments
Custom-Designed Anti-Microbial Peptides | Medgadget
Pharmaceuticals | Free Full-Text | Antimicrobial Peptides from Fish
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
Hepcidin (Liver Expressed Antimicrobial Peptide 1 or Putative Liver Tumor Regressor or HAMP) - Pipeline Review, H2 2016
Publications
Azurocidin - inactive serine proteinase homolog acting as a multifunctional inflammatory mediator. - Acta Biochimica Polonica -...
Host Defense Peptides and the New Line of Defence Against Multire...: Ingenta Connect
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted...
தவளைகளிடமிருந்து வைரஸ் காய்ச்சலை தடுக்கும் மருந்துகள் - நவீன அறிவியல்
Nanomechanical response of bacterial cells to cationic antimicrobial peptides - Soft Matter (RSC Publishing)
Publications
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis...
Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37 -...
Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory...
Biomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ELISA
| Fisher Scientific
The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study<...
The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity
Antimicrobial peptide LL-37 on surfaces presenting carboxylate anions<...
PTH/PTHrP and Vitamin D Control Antimicrobial Peptide Expression and Susceptibility to Bacterial Skin Infection | Science...
Antimicrobial peptides derived from growth factors
tuberculosis1
Rapid sequence divergence in mammalian beta-defensins by adaptive evolution<...
LL17-32
Distinct antimicrobial peptide expression determines host species-specific bacterial associations - Franzenburg Sören
Human CAMP ELISA Kit Human CAMP ELISA Kit : Plasmid,ELISA Kits,antibodies,strains, - Nova lifetech Inc
Novel Gemini vitamin D3 analogs - Danish National Research Database-Den Danske Forskningsdatabase
The Gift For Life Felines - GENOSTIM
Polynucleotide phosphorylase negatively regulates DNA-mediated aggregation and serum resistance in Neisseria meningitidis
Lipopolysaccharide binding protein - Wikipedia
The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes...
KAKEN - Research Projects | Study on the interaction between periodontal bacteria and human antimicrobial peptides (KAKENHI...
Manipulation of the hepcidin pathway for therapeutic purposes | Haematologica
Anti-Biofilm Peptides
The Role of Antimicrobial Peptides at the Ocular Surface<...
Crystal structure and functional mechanism of a human antimicrobial membrane channel | PNAS
June, 2016 | Caspase1-Inhibitors caspase1inhibitor.com
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including...
Design, synthesis and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. - ARC Centre for...
Azurophilic granule - Wikipedia
The antimicrobial peptide Tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents...
Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue...
KoreaMed
Antimicrobial Peptides and Peptaibols, Substitutes for Conventional Antibiotics | Bentham Science
ALZFORUM | NETWORKING FOR A CURE
Scientific Protocols -
Production of recombinant hBD-1 in Escherichia coli and its specific polyclonal antibody in rabbits
Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae) |...
weisshaa | UW-Madison Department of Chemistry
Changes in serum hepcidin according to thyrometabolic status in patients with Graves disease in: Endocrine Connections Volume...
Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral,...
Suppression of Iron-Regulatory Hepcidin by Vitamin D | American Society of Nephrology
OpenEmory | Search Results
Esculentin-2-MG1 antimicrobial peptide precursor - Creative Peptides
Antimicrobial peptides extend lifespan in Drosophila<...
Babitt, J.L. and Lin, H.Y. (2010) Molecular Mechanisms of Hepcidin Regulation Implications for the Anemia of CKD. American...
Ontogeny and modulation after PAMPs stimulation of β-defensin, hepcidin, and piscidin antimicrobial peptides in meagre (|i...
Impact of Host Defense Peptides on Chronic Wounds and Infections | SpringerLink
Vitamin D Reduces Symptoms in Subjects Frequent Respiratory Infections
Liver-expressed antimicrobial peptide
LEAP2 is a cysteine-rich, and cationic protein. LEAP2 contains a core structure with two disulphide bonds formed by cysteine ... Liver-expressed antimicrobial peptides are a family of mammalian liver-expressed antimicrobial peptides (LEAP). The exact ... In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial ... a novel blood peptide expressed in the liver". Protein Sci. 12 (1): 143-52. doi:10.1110/ps.0213603. PMC 2312392. PMID 12493837 ...
Antimicrobial peptides
There are some factors that are closely related to the selectivity property of antimicrobial peptides, among which the cationic ... including antimicrobial peptides, in a protein sequence PeptideRanker Bioactive peptide, including antimicrobial peptide, ... Currently, the most widely used antimicrobial peptide is nisin; being the only FDA approved antimicrobial peptide, it is ... In the competition of bacterial cells and host cells with the antimicrobial peptides, antimicrobial peptides will ...
Cell-penetrating peptide
Helical β-peptides mimic antimicrobial activities of host defense peptides. This feature requires the orientation of cationic - ... "Inhibition of herpes simplex virus type 1 infection by cationic beta-peptides". Antimicrobial Agents and Chemotherapy. 52 (6): ... "A Noncovalent Peptide-Based Strategy for Peptide and Short Interfering RNA Delivery". Handbook of Cell-Penetrating Peptides, ... In the absence of linker, the cationic peptide can interact more efficient with the target cell and cellular uptake occurs ...
MP196
... is a synthetic antimicrobial peptide. It falls under the structural class: short cationic peptides. Since it is a short ... April 2014). "Small cationic antimicrobial peptides delocalize peripheral membrane proteins". Proceedings of the National ... MP196 can be used as the key structure in order to develop any potential antimicrobial peptides which could help in fighting ... as this cationic peptide prefers incorporating into membranes which have a higher negatively charged phospholipid ratio. ...
Fixation (histology)
"Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria". Antimicrobial Agents and ...
Robert E. W. Hancock
This then led to investigating small cationic peptides from nature, originally termed cationic antimicrobial peptides, but ... Currently Hancock and his lab's research interests include small cationic peptides as novel antimicrobials, broad-spectrum anti ... Hancock, R.E.W. (2001). "Cationic peptides: effectors in innate immunity and novel antimicrobials". The Lancet Infectious ... Hancock REW, Haney EF, Gill EE (2016). "The immunology of host defence peptides: Beyond antimicrobial activity". Nat Rev ...
Suzana Straus
... comparison with cationic antimicrobial peptides and lipopeptides". Biochimica et Biophysica Acta. 1758 (9): 1215-1223. doi: ... Raheem, Nigare; Straus, Suzana K. (2019). "Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm ... Straus has smultaneously looked to establish structure-function relationships in antimicrobial peptides. Suzana Straus; Robert ... Prashant Kumar; Jayachandran N Kizhakkedathu; Suzana K Straus (19 January 2018). "Antimicrobial Peptides: Diversity, Mechanism ...
Oxyopinin
It is also 29% identical to the amino acid residues of the frog antimicrobial peptide dermaseptin. Oxyopinins 2a, 2b, 2c, and ... They are the largest linear cationic amphipathic peptides detected in the venom of any spider. They are structurally α-helical ... The sixth peptide oxyopinin 4a (Oxt-4a) was reported in 2011 from Oxyopes takobius. It is composed of 77 amino acid residues, ... The first five peptides, namely oxyopinins 1, 2a, 2b, 2c, and 2d, were described in 2002 from Oxyopes kitabensis. Oxyopinin 1 ...
Magainin
The magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). The peptides are ... cationic, generally lack a stable conformation in water but form amphipathic α-helix in membranes; their mechanism against ... Protein pages needing a picture, Antimicrobial peptides). ... "Host-defense peptides in skin secretions of African clawed ...
Lactoferricin
... is an amphipathic, cationic peptide with anti-microbial and anti-cancer properties. It can be generated by the ... June 2016). "Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine". ... Gifford JL, Hunter HN, Vogel HJ (November 2005). "Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, ... and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural ...
GsMTx-4
... also serves as a cationic antimicrobial peptide against Gram-positive bacteria. GsMTx-4 was isolated from the venom of ... Compared with other ICK peptides, GsMTx-4 has a relatively high content of lysine residues, which causes the peptide to be more ... This amphiphilic peptide, which consists of 35 amino acids, belongs to the inhibitory cysteine knot (ICK) peptide family. It ... Unlike other ICK peptides, the action of GsMTx-4 is not stereospecific, as both L- and D-GsMTx-4 can block MSCs. Published KD ...
Defensin
Cationic Antimicrobial Proteins', 'Neutrophil peptides', 'Gamma thionins' amongst others. Proteins called 'defensins' are not ... From this point of view, defensins (as well as antimicrobial peptides in general) are of great interest. It was shown that ... In this sense, the intestinal production of antimicrobial peptides as hBD2 and hBD4 by trefoil from milk might play an ... Wang YP, Lai R (February 2010). "[Insect antimicrobial peptides: structures, properties and gene regulation]". Dong Wu Xue Yan ...
Surgical mesh
"Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide". Materials. 12 ( ... As a drug delivery system, a hernia mesh can be used to deliver antibiotics, antiseptics, antimicrobials, antimicrobial ... FDA Approved Antimicrobial Hernia Meshes MycroMesh and DualMesh Plus by GORE XenMatrix Surgical Graft by BD Ventrio Hernia ... Are antimicrobial biomaterials the longed-for solution?". Biomaterials. 167: 15-31. doi:10.1016/j.biomaterials.2018.03.017. hdl ...
Dermaseptin
Mor A (2000). "Peptide-based antibiotics: a potential answer to raging antimicrobial resistance". Drug Development Research. 50 ... Hancock RE, Falla T, Brown M (1995). "Cationic bactericidal peptides". Advances in Microbial Physiology. 37: 135-75. PMID ... After transient loading of the cells with the non-toxic dermaseptin S4 analogue K4-S4(1-13)a, the peptide is transported in the ... Antimicrobial resistance Amiche M, Seon AA, Pierre TN, Nicolas P (August 1999). "The dermaseptin precursors: a protein family ...
Phagocytosis
Other antimicrobial peptides are present in these granules, including lactoferrin, which sequesters iron to provide ... Oxygen-independent degradation depends on the release of granules, containing enzymes such as lysozymes, and cationic proteins ...
Murepavadin
It is a synthetic cyclic beta hairpin peptidomimetic based on the cationic antimicrobial peptide protegrin I (PG-1) and the ... The host defense antimicrobial peptide protegrin I (PG-1), exhibits broad-spectrum antimicrobial activity and good activity ... "Macrocyclic hairpin mimetics of the cationic antimicrobial peptide protegrin I: a new family of broad‐spectrum antibiotics". ... "Properties and structure-activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide ...
Cyanase
... that as a novel cationic α-helical antimicrobial peptide, known by CL 14-25. Cyanase is also important as an energy metabolizer ... "Antimicrobial activity and mechanism of action of a novel cationic α-helical dodecapeptide, a partial sequence of cyanate lyase ... doi:10.1016/j.peptides.2012.12.015. PMID 23270672. S2CID 56770. Palatinszky M, Herbold C, Jehmlich N, Pogoda M, Han P, von ...
Pseudin
... is a peptide derived from Pseudis paradoxa. Pseudins have some antimicrobial function. There are several different ... Its secondary/tertiary structure consists of one cationic amphipathic α-helix. Pseudin-2 was shown to have potent antibacterial ... Olson, L.; Soto, A. M.; Knoop, F. C.; Conlon, J. M. (2001-11-09). "Pseudin-2: an antimicrobial peptide with low hemolytic ... ISBN 0-85404-242-3. Rinaldi AC (2002). "Antimicrobial peptides from amphibian skin: an expanding scenario". Curr Opin Chem Biol ...
Histone H2A
Antimicrobial peptide: Histones are conserved eukaryotic cationic proteins present in the cells and are involved in the ... Histone H2A variant is reported to be involved in host immune response by acting as antimicrobial peptides (AMPs). H2A are α- ... "An unconventional antimicrobial protein histone from freshwater prawn Macrobrachium rosenbergii: analysis of immune properties ... amphipathic protein with hydrophobic and hydrophilic residues on opposing sides that enhances the antimicrobial activity of H2A ...
Azurocidin 1
Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is ... Pereira HA, Erdem I, Pohl J, Spitznagel JK (1993). "Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil ... "Entrez Gene: AZU1 azurocidin 1 (cationic antimicrobial protein 37)". Soehnlein, Oliver; Lindbom, Lennart (2009). "Neutrophil- ... granule-associated cationic antimicrobial protein chemotactic for monocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4733-7. ...
Alpha helix
Common to many of them is that the hydrophobic face of the antimicrobial peptide forms pores in the plasma membrane after ... "Role of Cationic Side Chains in the Antimicrobial Activity of C18G". Molecules. 23 (2): 329. doi:10.3390/molecules23020329. PMC ... This pattern is especially common in antimicrobial peptides, and many models have been devised to describe how this relates to ... Toke, Orsolya (2005). "Antimicrobial peptides: new candidates in the fight against bacterial infections". Biopolymers. 80 (6): ...
Beta defensin
"Tracheal antimicrobial peptide, a novel cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of ... Making non-oxidative mechanisms, such as lysosomes and cationic peptides, even more important. β-defensins genes are found ... The first beta-defensin discovered was Tracheal Antimicrobial Peptide, found in the bovine airway in 1991. The first human beta ... When the receptors are activated a cascade reaction will take place and substances such as cytokines and antimicrobial peptides ...
Beta-defensin 2
Human beta-defensin-2 (hBD-2) is a cysteine-rich cationic low molecular weight antimicrobial peptide recently discovered in ... Beta-defensin 2 (BD-2) also known as skin-antimicrobial peptide 1 (SAP1) is a peptide that in humans is encoded by the DEFB4 ( ... Carothers DG, Graham SM, Jia HP, Ackermann MR, Tack BF, McCray PB (2001). "Production of beta-defensin antimicrobial peptides ... Weinberg A, Krisanaprakornkit S, Dale BA (1999). "Epithelial antimicrobial peptides: review and significance for oral ...
GDF2
... is a potent inducer of hepcidin (a cationic peptide that has antimicrobial properties) in liver cells (hepatocytes) and ... GDF2 contains an N-terminal TGF-beta-like pro-peptide (prodomain) (residues 56-257) and a C-terminal transforming growth factor ...
DEFA5
Defensins are a family of microbicidal and cytotoxic peptides (antimicrobial peptides; AMP) that are involved in host defense, ... Defensins are small cationic peptides linked via three intra-molecular disulfide bridges, and contain six intra-molecular ... Bevins CL, Salzman NH (May 2011). "Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis". Nature ... implications for antimicrobial peptides in host defense of the human bowel". FEBS Letters. 315 (2): 187-92. doi:10.1016/0014- ...
Alveolar macrophage
These organelles contain a myriad of degradative enzymes and antimicrobial peptides that are released into the phagolysosome, ... and on the synthesis of toxic cationic polypeptides. Macrophages possess a repertoire of antimicrobial molecules packaged ... Normally mature TGFβ is secreted as a latent complex with its N-terminal fragment, latency-associated peptide (LAP), which ... such as proteases, nucleases, phosphatases, esterases, lipases, and highly basic peptides. Moreover, macrophages possess a ...
Class II bacteriocin
It includes the alpha enterocins and lactococcin G peptides. These peptides have some antimicrobial properties; they inhibit ... This cationic N-terminal beta-sheet domain mediates binding of the class IIa bacteriocin to the target cell membrane. The C- ... Fimland G, Nissen-Meyer J, Johnsen L (2005). "The C-terminal domain of pediocin-like antimicrobial peptides (class IIa ... Dalhus B, Fimland G, Nissen-Meyer J, Johnsen L (2005). "Pediocin-like antimicrobial peptides (class IIa bacteriocins) and their ...
Lipid A acylase
PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response. Hwang PM, ... Antimicrobial peptide resistance and lipid A acylation protein PagP is a family of several bacterial antimicrobial peptide ...
Staphylococcus schleiferi
... antimicrobial therapeutic agents and is thought to also provide protection against host defense cationic antimicrobial peptides ... Antimicrobial therapy has been generally successful in treatment of infections, however, resistance to beta-lactam antibiotics ... Although the current antimicrobials commonly used for treatment of S. schleiferi caused infections experimentally show ... Owners of dogs affected by deep pyoderma carried multiple anti-microbial resistant strains of S. intermedius which is thought ...
Formyl peptide receptor 2
Cathelicidin-related antimicrobial peptides, numerous Pleurocidins which are a family of cationic antimicrobial peptides found ... which is a frog-derived antimicrobial peptide ((pro-inflammatory products derived from host anti-microbial proteins); and j) ... Eicosanoid receptor Formyl peptide receptor Lipoxin Resolvin Formyl peptide receptor 1 Formyl peptide receptor 3 GRCh38: ... Pundir P, Catalli A, Leggiadro C, Douglas SE, Kulka M (Jan 2014). "Pleurocidin, a novel antimicrobial peptide, induces human ...
Histatin
... s are histidine-rich (cationic) antimicrobial proteins found in saliva. Histatin's involvement in antimicrobial ... v t e (Articles with short description, Short description matches Wikidata, Membrane proteins, Antimicrobial peptides, All stub ... ISBN 978-1-55581-539-4. Kavanagh K, Dowd S (March 2004). "Histatins: antimicrobial peptides with therapeutic potential" (PDF). ... Swidergall, Marc; Ernst, Joachim F. (August 2014). "Interplay between Candida albicans and the Antimicrobial Peptide Armory". ...
Arenicin
"NZ17074 - A Novel antimicrobial peptide showing potent in vitro activity against gram negative multi-resistant clinical ... Cationic residues on arenicin-3 interacts with negatively charged lipopolysaccharides on the outer membrane of Gram-negative ... Arenicins are a group of antimicrobial peptides being studied to combat Gram-negative bacteria. The arenicin family consists of ... a novel antimicrobial peptide from marine polychaeta Arenicola marina". FEBS Letters. 577 (1-2): 209-14. doi:10.1016/j.febslet. ...
Innate immune system
Antimicrobial peptides are an evolutionarily conserved component of the innate immune response found among all classes of life ... can cause lysis of many Gram-positive bacteria by acting as a cationic detergent. Many acute-phase proteins of inflammation are ... Several species of insect produce antimicrobial peptides known as defensins and cecropins. In invertebrates, PRRs trigger ... In addition, some of the products of the coagulation system are directly antimicrobial. For example, beta-lysine, a protein ...
Cathelicidin
Antimicrobial peptides Innate immune system Peptoid "Entrez Gene: CAMP cathelicidin antimicrobial peptide". UniProt entry: ... "Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human ... The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). The AMP family also includes the defensins ... a synthetic antimicrobial and antibiofilm peptide) is a modified version of LL-37 that has enhanced antimicrobial activities ...
Lacritin
... and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification". J Proteome Res. 14 (6): 2649- ... that likely interacts with the cationic face of lacritin's C-terminal amphipathic alpha helix), and an N-terminal chondroitin ... Each peptide inserts rapidly into (O-acyl)-omega-hydroxy fatty acid (OAHFA) thought to reside at the aqueous lipid boundary in ... In both cases, stability is largely restored by spiking in synthetic lacritin peptides N-94 or N-94/C-6 as proxy C-terminal ...
Granulocyte
Antimicrobial agents (Defensins and Eosinophil cationic protein) Enzymes Acid hydrolases: further digest bacteria Lysozyme: ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... Neutrophils have three strategies for directly attacking micro-organisms: phagocytosis (ingestion), release of soluble anti- ... Primary granules contain cationic proteins and defensins that are used to kill bacteria, proteolytic enzymes and cathepsin G to ...
Amphiphile
Antimicrobial peptides (AMPs) are another class of amphiphilic molecules, a big data analysis showed that amphipathicity best ... Some typical members of this group are: sodium dodecyl sulfate (anionic), benzalkonium chloride (cationic), cocamidopropyl ... of antimicrobial activities in relation to amphipathicity and charge reveals novel characterization of antimicrobial peptides ... Schubert, D; Behl, C; Lesley, R; Brack, A; Dargusch, R; Sagara, Y; Kimura, H (14 March 1995). "Amyloid peptides are toxic via a ...
Vancomycin
The three peptide syntheses are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis ... Vancomycin activity is considered to be time-dependent; that is, antimicrobial activity depends on the duration that the serum ... re-gained the antibacterial power of vancomycin by modifying the molecule with a cationic oligopeptide. The oligopeptide ... Nonribosomal peptide synthesis occurs through distinct modules that can load and extend the protein by one amino acid per ...
Pardaxin
This article incorporates text from the public domain Pfam and InterPro: IPR009990 (Protein families, Antimicrobial peptides). ... Its 33-amino acid structure contains many cationic and amphipathic amino acids. This makes it easier for it to interact with ... Yeaman MR, Yount NY (March 2003). "Mechanisms of antimicrobial peptide action and resistance". Pharmacological Reviews. 55 (1 ... Oren Z, Shai Y (April 1996). "A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide ...
Pseudomonas aeruginosa
... compensates for a lack of lipopolysaccharide aminoarabinose modification-dependent resistance to the antimicrobial peptide ... September 2015). "Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm ... Combination therapy after rigorous antimicrobial susceptibility testing has been found to be the best course of action in the ... Use of β-lactamase inhibitors such as sulbactam has been advised in combination with antibiotics to enhance antimicrobial ...
Surfactin
doi:10.1016/0927-7765(94)01183-6. Mor, A. Peptide-based antibiotics: A potential answer to raging antimicrobial resistance. ... The pore-forming (ion channel) effect is characterized by the formation of cationic channels. It would require surfactin to ... The structure of the main congener consists of a peptide loop of seven amino acids (L-glutamic acid, L-leucine, D-leucine, L- ... ISBN 978-0-683-00603-2. Heerklotz H, Seelig J (September 2001). "Detergent-like action of the antibiotic peptide surfactin on ...
Irshad Hussain
Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria' ACS Omega, 2018. 'Metal ... Rational and combinatorial design of peptide capping ligands for gold nanoparticles' JACS, 2004. 'Emulsion-templated gold beads ... "Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria". ACS Omega. 3 (12): 16721-16727. ... "Rational and Combinatorial Design of Peptide Capping Ligands for Gold Nanoparticles". Journal of the American Chemical Society ...
Staining
Acridine orange (AO) is a nucleic acid selective fluorescent cationic dye useful for cell cycle determination. It is cell- ... Collagen Hybridizing Peptide (CHP) staining allows for an easy, direct way to stain denatured collagens of any type (Type I, II ... "Impact of Reporting Gram Stain Results From Blood Cultures on the Selection of Antimicrobial Agents". American Journal of ... Safranine (or Safranine O) is a red cationic dye. It binds to nuclei (DNA) and other tissue polyanions, including ...
Cupiennin
They are chemically cationic α-helical peptides. They were isolated and identified in 2002 as a family of peptides called ... a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae)". J Biol Chem. 277 ( ... These peptides are highly cationic, made up of similar amino acids, but different in the N- and C-terminal ends. The ... Cupiennin 1 family is the more well-known group, and consists of at least four peptides, such as cupiennin 1a, 1b, 1c, and 1d. ...
Cliotide
Butelase 1 is the fastest peptide ligase known capable of catalyzing peptide cyclization at an extraordinary efficiency. Nguyen ... At a concentration of 1 μM, cationic cliotides are capable of augmenting the secretion of various cytokines and chemokines in ... Cliotides display in vitro antimicrobial activity against E. coli, K. pneumoniae, and P. aeruginosa and cytotoxicity against ... Cliotides are a group of related peptides that have been isolated from the heat-stable fraction of Clitoria ternatea (Cliotides ...
Thiomer
Because of their antimicrobial activity, thiolated polymers are also used as coatings that avoid bacterial adhesion. Thiomers ... Many non-invasively administered drugs such as therapeutic peptides or nucleic acids are degraded on the mucosa by membrane ... Priya, SS; Rekha, MR (2016). "Disulphide cross linked pullulan based cationic polymer for improved gene delivery and efflux ... potential excipients for non-invasive peptide delivery systems". Eur. J. Pharm. Biopharm. 58 (2): 253-263. doi:10.1016/j.ejpb. ...
Colistin
... is a polycationic peptide and has both hydrophilic and lipophilic moieties. These cationic regions interact with the ... Pamp SJ, Gjermansen M, Johansen HK, Tolker-Nielsen T (2008). "Tolerance to the antimicrobial peptide colistin in Pseudomonas ... Non-ribosomal peptide biosynthesis begins with a loading module and then the addition of each subsequent amino acid. The ... This continues with each amino acid until the linear peptide chain is completed. The last module will have a thioesterase to ...
Browsing SEARO Publications by Subject "Antimicrobial Cationic Peptides"
Browsing by Subject "Antimicrobial Cationic Peptides"
Dryad Data -- A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by...
The raw data of "A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by ... Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing ... 2018), Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by ... Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants ...
Antimicrobial Cationic Peptides | Profiles RNS
"Antimicrobial Cationic Peptides" by people in this website by year, and whether "Antimicrobial Cationic Peptides" was a major ... Antimicrobial Cationic Peptides*Antimicrobial Cationic Peptides. *Cationic Peptides, Antimicrobial. *Peptides, Antimicrobial ... "Antimicrobial Cationic Peptides" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Antimicrobial Cationic Peptides" by people in Profiles. ...
Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant...
Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial Peptides (CAMPs) ... Table 1 In vitro antibacterial activity of cationic antimicrobial peptides against methicillin-resistant and -susceptible S. ... Cationic Antimicrobial Peptides (CAMPs) appear to be promising candidates to overcome resistance [15,16,17]. CAMPs are a large ... Hancock R. Review Cationic peptides : effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 2001;1 October: ...
TCDB » Superfamilies
Ciumac D, Gong H, Hu X, Lu JR (2018). Membrane targeting cationic antimicrobial peptides. J Colloid Interface Sci 537: 163-185 ... 1.C.76 - The Pore-forming Maculatin Peptide (Maculatin) Family. 1.C.124 - The Antimicrobial Pore-forming Pandinin (Pin) Family ... 2012). Natural antimicrobial peptides from bacteria: characteristics and potential applications to fight against antibiotic ... 8.B.7 - The Cl- Channel Peptide Inhibitor (GaTx1) Family. 8.B.8 - The α-KTx15 scorpion toxin (α-KTx15) Family. ...
Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages - NRC Publications...
Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages ... Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages. DOI. Resolve DOI: ... Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages. From National ... Overall, the data indicate a pro-inflammatory effect of the three cationic antimicrobial peptides in the inflammatory response ...
Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: Application to the...
Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition.pdf non disponibili ... Cationic antimicrobial peptides (CAMPs) are essential components of innate immunity. Here we show that antimicrobial potency of ... Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: Application to the ... Cationic antimicrobial peptides (CAMPs) are essential components of innate immunity. Here we show that antimicrobial potency of ...
DeCS - Termos Novos
Chemerin is an antimicrobial agent in human epidermis
Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that ... Antimicrobial Cationic Peptides / chemistry * Antimicrobial Cationic Peptides / genetics * Antimicrobial Cationic Peptides / ... Chemerin is an antimicrobial agent in human epidermis PLoS One. 2013;8(3):e58709. doi: 10.1371/journal.pone.0058709. Epub 2013 ... Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that ...
Advanced Search Results - Public Health Image Library(PHIL)
TNR
Antimicrobial cationic peptides (AMPs) are ubiquitous little proteins utilized by living. immune Uncategorized Ki8751, TNR ... Antimicrobial cationic peptides (AMPs) are ubiquitous little proteins utilized by living cells to guard against a broad ... through the production of antimicrobial peptides (AMPs) [30,31] that have a wide distribution from microorganisms to complex ...
KEGG COMPOUND: C00346
Browsing Science (Faculty of) by Subject "Proteins"
Toxins | Free Full-Text | Antimicrobial Properties of Apis mellifera's Bee Venom
It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds ... The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The ... To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of ... this review is to address the antimicrobial properties of BV and its compounds. ...
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis |...
Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur. J. Immunol. 45, 203-213 ... Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J. Exp. Med. 206, 1983-1994 ( ... Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. Nat. Commun. 10, 1012 ( ... Lee, E. Y., Lee, M. W. & Wong, G. C. L. Modulation of toll-like receptor signaling by antimicrobial peptides. Semin. Cell Dev. ...
Biblio | Linus Pauling Institute | Oregon State University
Antimicrobial Cationic Peptides. Jiang J, Zhang Y, Indra AK, Ganguli-Indra G, Le MN, Wang H, Hollins RR, Reilly DA, Carlson MA ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ...
Immunotherapy for Pulmonary TB
Table 1. Relevance of antimicrobial peptides in TB. Antimicrobial peptide. Source. Activity. Importance in TB. Ref.. ... AMPs are small cationic molecules of a variable length. These peptides mainly constitute polar-hydrophilic, nonpolar- ... The use of antimicrobial peptides (AMPs) and AMP inducers are a promising option for the immunotherapy of TB by using them as ... Induction of this antimicrobial peptide reduce mycobacterial loads. [22,25,41,55,78]. ...
Hansen, Jørn H | UiT
Gillian Morrison - Fingerprint - University of Edinburgh Research Explorer
Design and Application of Antimicrobial Peptide Conjugates - Kölner UniversitätsPublikationsServer
CELL-PENETRATING PEPTIDE; GRAM-NEGATIVE BACTERIA; CATIONIC PEPTIDES; ANTIBACTERIAL PEPTIDES; ESCHERICHIA-COLI; AMINO-ACID; ... Design and Application of Antimicrobial Peptide Conjugates. Int. J. Mol. Sci., 17 (5). BASEL: MDPI. ISSN 1422-0067 ... Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and ... AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years ...
Utilisation of peptides against microbial infections - a review
Antimicrobial peptides (AMPs) seem to meet these expectations. AMPs are produced by bacteria, viruses, plants, and animals, and ... The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. ... Cationic antimicrobial peptides: towards clinical applications. Expert Opin Investig Drugs. 2000; 9(8): 1723-1729. ... Antimicrobial peptides may be applied topically and systemically. Among the peptides used topically, a very important area for ...
KEGG T01145: ROD 44461
Author: maria / Subject term: chloramphenicol - PubAg Search Results
The cationic antimicrobial peptides present a promise to be used to develop more efficient drugs applied to human health. The ... antimicrobial cationic peptides; chloramphenicol; drugs; genetic databases; genome; genomics; human health; humans; ... Predicting antimicrobial peptides from eukaryotic genomes: In silico strategies to develop antibiotics ... Antimicrobial resistance (AMR) is a growing global public health problem, which is caused by the use of antimicrobials in both ...
Frontiers | Soluble Mediators Regulating Immunity in Early Life
The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, ... The complement system, antibodies, and antimicrobial proteins and peptides (APPs), can directly interact with potential ... The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and ... Anti-Microbial Proteins and Peptides. Anti-microbial proteins and peptides play a critical role in innate immunity by directly ...
Portal LIS - Localizador de Informação em Saúde
British Library EThOS: Bioinformatics approaches to structure and function of antimicrobial peptides
Their activity is determined by numerous properties such as cationic charge, amphipathicity, size, and amino acid composition. ... Antimicrobial peptides (AMPs) are among the leading alternatives to current antibiotics, exhibiting broad spectrum activity. ... Antimicrobial resistance within a wide range of infectious agents is a severe and growing public health threat. ... The results presented in this work give an overview of the range of protein scaffolds that naturally bear antimicrobial ...
RCSB PDB - 2L3I: Oxki4a, spider derived antimicrobial peptide
A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius ( ... AOXKI4A, antimicrobial peptide in spider venom. A. 30. Oxyopes takobius. Mutation(s): 0 Membrane Entity: Yes ... A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius ( ... Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin.. Dubovskii, P.V., ...
Crucial roles of charged saccharides in the survival of Gram-negative bacteria
For example, cationic antimicrobial peptides (CAPs) have drawn increasing attention as alternatives to chemical food ... LPSs are supposed to play crucial roles in the survival of bacteria against antimicrobial peptides. This finding inspires the ... and divalent cations on the survival of Gram-negative bacteria against cationic peptides like protamine. As the minimal ...
ResistanceAMPsBroad-spectrumGRAM-NEGATIVEDefensinsProteinsAntibioticsEndogenousInflammatory responseBacterialSyntheticHumansSignal peptideHemolytic activityCompoundsMembraneActivityXenopusHydrophobicInsectMicroorganismsCathelicidinMimicDefenseCAMPsInfectionsVivoDrugsClinicalMeSHIntramolecularViralInhibitorsCellsCompositionBindsVenomImmuneMolecularSmallActiveInfectionPropertiesMinimalOwingCircularFindingsSignificantly
Resistance11
- P. aeruginosa infections are often severe, life threatening and difficult to treat because of the limited susceptibility to antimicrobial agents due to the numerous mechanisms of resistance that this organism has accumulated [ 13 ]. (biomedcentral.com)
- The slope of the regression line describing the correlation 'antimicrobial potency'/'C(m)H(n)L product' changes from strain to strain indicating that some strains acquired a higher resistance to CAMPs than others. (unina.it)
- Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. (uni-koeln.de)
- The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. (aaem.pl)
- The limitations in the use of peptides in the treatment of infections, such as susceptibility to proteolysis, and resistance of microorganisms to the peptides, are also discussed. (aaem.pl)
- As the presence of antibiotics in environmental waters enhances antimicrobial resistance, photolysis and heterogeneous photocatalysis of chloramphenicol (CAP) were evaluated in deionized water (DW) and in sewage treatment plant (STP) effluent under black light and solar irradiation. (usda.gov)
- Antimicrobial resistance within a wide range of infectious agents is a severe and growing public health threat. (bl.uk)
- Summary: Emergence of resistance to the antibiotics currently employed in clinical practice is a continual stimulus for further research aimed at identifying novel antimicrobial compounds. (elsevier.com)
- Health care personnel must appreciate that only judicious use of antimicrobial drugs will prevent the further uncontrolled spread of bacterial resistance. (elsevier.com)
- Numerous antimicrobial protocols are used to treat PRRS, but we have little insight into how these treatment schemes impact antimicrobial resistance (AMR) dynamics within the fecal microbiome of commercial swine. (biomedcentral.com)
- Antimicrobial resistance gene (ARG) richness and diversity were significantly higher at earlier time points, while microbiome richness and diversity were significantly lower. (biomedcentral.com)
AMPs10
- Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants, non-mammalian vertebrates, and mammals. (datadryad.org)
- AMPs are small cationic molecules of a variable length. (medscape.com)
- [ 1 ] AMPs are broadly distributed in nature and all of them share fundamental structural characteristics that are very important for their broad-spectrum antimicrobial activity, such as length (less than 60 amino acids), amphipathic structure and the presence of cationic amino acids in their structure, providing them with a partial positive charge. (medscape.com)
- However, due to their secondary structural characteristics, AMPs could be divided into subcategories that include: α-helical, peptides enriched with repetition of one amino acid, and peptides with intramolecular bonding formed by cysteines. (medscape.com)
- AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. (uni-koeln.de)
- Antimicrobial peptides (AMPs) seem to meet these expectations. (aaem.pl)
- Antimicrobial peptides (AMPs) are among the leading alternatives to current antibiotics, exhibiting broad spectrum activity. (bl.uk)
- The results presented in this work give an overview of the range of protein scaffolds that naturally bear antimicrobial activity, give an insight into AMPs' interactions with bacterial membrane and are a step forward in protein design efforts towards better AMPs. (bl.uk)
- One common feature among cationic AMPs is an amidated C-terminus that provides greater stability against in vivo degradation. (edu.au)
- The amphibian temporins, amongst the smallest antimicrobial peptides (AMPs), are α-helical, amphipathic, hydrophobic and cationic and are active mainly against Gram-positive bacteria but inactive or weakly active against Gram-negative bacteria. (qub.ac.uk)
Broad-spectrum5
- Synthetic Oxt 4a was produced and shown to possess strong and broad-spectrum cytolytic and antimicrobial activity. (rcsb.org)
- Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. (uncg.edu)
- Broad-spectrum antimicrobials used to be the most common therapy to achieve a certain control on infections. (dovepress.com)
- Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. (peprotech.com)
- We have previously reported that a C60 fullerene functionalized with three dimethylpyrrolidinium groups (BF6) is a highly active broad-spectrum antimicrobial photosensitizer in vitro when combined with white-light illumination. (perkinelmer.com)
GRAM-NEGATIVE2
- Since the removal or mutation of LPSs is known to result in the death of Gram-negative bacteria, LPSs are supposed to play crucial roles in the survival of bacteria against antimicrobial peptides. (esrf.fr)
- Here we reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of Gram-negative bacteria against cationic peptides like protamine. (esrf.fr)
Defensins3
- Defensins are cationic peptides, produced by various human tissues, which serve as antimicrobial effectors of the immune system. (uni-konstanz.de)
- Plant defensins are small cationic peptides with antimicrobial activity and are integral part of the plant innate immune system. (edu.au)
- Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides), which include cathelicidins and defensins, are key components of the innate immune system that are upregulated during infection and inflammation. (cdc.gov)
Proteins5
- The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, protecting against systemic infection. (frontiersin.org)
- Additionally, several classes of proteins, including immunoglobulins (Igs), the complement system, and anti-microbial proteins and peptides (APPs), aid in the innate response to invading microorganisms and display age-dependent maturation (Figure 1 ). (frontiersin.org)
- Lower levels of complement proteins and anti-microbial proteins and peptides contribute to neonatal susceptibility to infection, while elevated levels of adenosine, adiponectin, and adrenomedullin in neonatal blood may influence immune cell polarization. (frontiersin.org)
- Scientists have been studying proteins produced by animals and humans, called cationic antimicrobial peptides (CAMPs), that the body uses to fight off infections. (harvard.edu)
- Salivary amylase, mucins, statherin, cystatins, and several cationic peptides are other proteins in saliva that form part of the innate immune system. (myassignmenthelp.com)
Antibiotics3
- Methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial Peptides (CAMPs) represent promising alternatives. (biomedcentral.com)
- Hancock RE, Lehrer R. Cationic peptides: a new source of antibiotics. (aaem.pl)
- For example, cationic antimicrobial peptides (CAPs) have drawn increasing attention as alternatives to chemical food preservatives and commonly used antibiotics. (esrf.fr)
Endogenous2
- 2018. 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression. . (oregonstate.edu)
- Fpn activity is suppressed by hepcidin, an endogenous peptide hormone, which inhibits iron export and promotes endocytosis of Fpn. (bvsalud.org)
Inflammatory response2
- Overall, the data indicate a pro-inflammatory effect of the three cationic antimicrobial peptides in the inflammatory response of salmonid species, suggesting a potential application of these peptides as immune adjuvant for fish vaccination. (canada.ca)
- Although at the beginning it was thought that these functions were only focused to promote proinflammatory conditions, it is now well known that some peptides, such as cathelicidin have ambiguous functions promoting, in certain cases, an anti-inflammatory response as well. (medscape.com)
Bacterial3
- Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis. (nih.gov)
- In swine, a major driver of antimicrobial use is porcine reproductive and respiratory syndrome (PRRS), which is caused by a virus that predisposes infected animals to secondary bacterial infections. (biomedcentral.com)
- We used maculatin 1.1 (Mac1) to assess the role of the capping groups in modulating the peptide bacterial efficiency, stability and interactions with lipid membranes. (edu.au)
Synthetic3
- A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). (nih.gov)
- 2008. Investigating the effect of increasing charge density on the hemolytic activity of synthetic antimicrobial polymers. . (umass.edu)
- 2008. Synthetic mimic of antimicrobial peptide with nonmembrane-disrupting antibacterial properties. . (umass.edu)
Humans1
- Phenotypic, genotypic, and antimicrobial characteristics of Streptococcus halichoeri isolates from humans, proposal to rename Streptococcus halichoeri as Streptococcus halichoeri subsp. (cdc.gov)
Signal peptide1
- Lamprey albumin contains a 23-amino acid putative signal peptide and a 6-residue putative propeptide, which, when cleaved, yield a mature protein of 1,394 amino acids with a calculated molecular weight of 157,000. (embl.de)
Hemolytic activity1
- The cationic β-sheet cyclic tetradecapeptide cyclo[VKLdKVdYPLKVKLdYP] (GS14dK 4 ) is a diastereomeric lysine ring-size analog of the potent naturally occurring antimicrobial peptide gramicidin S (GS) which exhibits enhanced antimicrobial but markedly reduced hemolytic activity compared to GS itself. (elsevier.com)
Compounds2
- Purpose of review: In this review, we highlight some of the developments achieved over the past 2 years in the field of novel antimicrobial compounds. (elsevier.com)
- A number of natural compounds including enzymes, essential oils, peptides, and chelators possess antimicrobial properties and are safe for human consumption. (naturalmedicinejournal.com)
Membrane5
- They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. (uni-koeln.de)
- Mihajlovic M, Lazaridis T. Antimicrobial peptides bind more strongly to membrane pores. (aaem.pl)
- Amphiphilic cationic ß 3R3 -peptides: membrane active peptidomimetics and their potential as antimicrobial agents. (mpg.de)
- Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membrane of microbes. (edu.au)
- Finally, we demonstrate that the affinity of binding of GS14dK4 to various phospholipid bilayer membranes is much more strongly correlated with the antimicrobial and hemolytic activities of this peptide than with its effect on the rate and extent of dye leakage in these model membrane systems. (elsevier.com)
Activity10
- We demonstrate that it is not only possible to identify and locate with very good precision the position of cryptic peptides, but also to analyze the internal structure of long CAMPs, thus allowing to draw an accurate map of the molecular determinants of their antimicrobial activity. (unina.it)
- Recombinant chemerin has antimicrobial activity. (nih.gov)
- This special conformation gives the molecule amphipathic and cationic properties, which are very important for their bactericidal activity. (medscape.com)
- Berrocal-Lobo M, Molina A, Rodriguez-Palenzuela P, Garcia-Olmedo F, Rivas L. Leishmania donovani: Thionins, plant antimicrobial peptides with leishmanicidal activity. (aaem.pl)
- Their activity is determined by numerous properties such as cationic charge, amphipathicity, size, and amino acid composition. (bl.uk)
- The present invention relates to a peptide having antibacterial or anti-inflammatory activity and a pharmaceutical composition containing the same as an active ingredient, and more particularly to a peptide having antibacterial or anti-inflammatory activity against dental bacteria, including periodontal pathogens, and bacteria causing atopic dermatitis, and to a pharmaceutical composition containing the peptide as an active ingredient. (justia.com)
- The inventive peptide having antibacterial or anti-inflammatory activity can be used for the treatment of both dental infectious diseases, including periodontitis or peri-implantitis, and inflammations, including atopy, psoriasis or arthritis. (justia.com)
- Antifungal and anti-biofilm activity of the first cryptic antimicrobial peptide from an archaeal protein against Candida spp. (univr.it)
- The antimicrobial peptide VLL-28, isolated from an archaeal transcription factor, shows comparable antifungal activity against 10 clinical isolates of Candida spp. (univr.it)
- Antimicrobial surfaces containing cationic nanoparticles: how immobilized, clustered, and protruding cationic charge presentation affects killing activity and kinetics. (umass.edu)
Xenopus1
- Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. (aaem.pl)
Hydrophobic2
- The ratio n/(m+n) can vary between ca. 0.5 and 1, thus indicating that some strains are sensitive to highly charged peptides, whereas others are particularly susceptible to more hydrophobic peptides. (unina.it)
- These peptides mainly constitute polar-hydrophilic, nonpolar-hydrophobic and positively charged amino acids. (medscape.com)
Insect2
Microorganisms1
- The purpose of this trial was to determine if a combination of naturally occurring antimicrobials can allow reduction and suppression of the invading microorganisms under physiological conditions, so when the combination is given to a patient before eating, the nutrients will be broken down and used by the body, the body will have time to heal, and the probiotics will establish control over the pathogenic bacteria. (naturalmedicinejournal.com)
Cathelicidin2
- We therefore evaluated the effect of cathelicidin peptides on disease caused by influenza A virus in mice. (cdc.gov)
- Influenza virus-infected mice treated with LL-37 had lower concentrations of pro-inflammatory cytokines in the lung than did infected animals that had not been treated with cathelicidin peptides. (cdc.gov)
Mimic1
- Previous studies have shown that small peptides that mimic the first few residues of hepcidin, i.e., minihepcidins, are more potent than hepcidin. (bvsalud.org)
Defense1
- Unlike other arachnid toxins, Oxt 4a exhibits striking similarity with defense peptides from the skin of ranid frogs that contain the so-called Rana-box motif (a C-terminal disulfide-enclosed loop). (rcsb.org)
CAMPs2
Infections4
- The aim of this study is to review the results of studies on the use of peptides to combat infections in vivo. (aaem.pl)
- In the combat against systemic infections are used such peptides as: P113D (modified P113 peptide containing D-amino acids), colistin, peptoids, and peptides containing non-typical amino acids or non-peptide elements. (aaem.pl)
- Antimicrobials are used in food-producing animals for purposes of preventing, controlling, and/or treating infections. (biomedcentral.com)
- CONCLUSION: These data suggest that cationic fullerenes have clinical potential as an antimicrobial photosensitizer for superficial infections where red light is not needed to penetrate tissue. (perkinelmer.com)
Vivo1
- In vitro and in vivo experiments suggested that the peptides may act directly on the influenza virion rather than via receptor-based mechanisms. (cdc.gov)
Drugs2
- Brandenburg L-O, Merres J, Albrecht L-J, Varoga D, Pufe T. Antimicrobial peptides: multifunctional drugs for different applications. (aaem.pl)
- These drugs will perhaps effectively fight against bacteria that now are scarcely controlled by the traditional antimicrobial agents. (elsevier.com)
Clinical1
- Eckert R. Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development. (aaem.pl)
MeSH1
- Antimicrobial Cationic Peptides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Intramolecular1
- Interestingly, two of the modelled peptides predicted to form β‐hairpins lacked the intramolecular disulphide bonds, cation‐π or aromatic interactions that generally stabilise such AMP structures. (bl.uk)
Viral1
- Events such as viral illness, antimicrobial exposures, and physical grouping of the pigs exerted significant yet relatively minor influence over this trajectory. (biomedcentral.com)
Inhibitors2
- Together, this led us to hypothesize that defensin-derived peptides are natural human inhibitors of virus infection with low toxicity. (uni-konstanz.de)
- Altogether, defensin-derived peptides, in particular HD5(1-9), qualify as promising candidates for further development as a novel class of HCMV entry inhibitors. (uni-konstanz.de)
Cells3
- and cyclo-oxygenase-2 (COX-2), increased in the peptide-treated RTS11 cells. (canada.ca)
- In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. (peprotech.com)
- Using a fluoresceinated derivative of this peptide, we found that VLL-28 binds to the surface of planktonic cells. (univr.it)
Composition1
- Despite very different antimicrobial exposures after challenge with PRRS virus, resistome composition remained largely similar between the treatment groups. (biomedcentral.com)
Binds1
- Specifically, this peptide binds much more tightly to anionic than to zwitterionic phospholipids and much less tightly to cholesterol-containing than to cholesterol-free model membranes. (elsevier.com)
Venom1
- A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius (Oxyopidae). (rcsb.org)
Immune1
- There are increasing evidence of the potential role of antimicrobial peptides in the regulation of immune responses in mammalian species. (canada.ca)
Molecular2
- Deduction of the molecular masses of each mature processed peptide from respective cloned cDNAs was used to locate respective molecules in reverse-phase HPLC fractions of secretion. (qub.ac.uk)
- 2008. Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach. . (umass.edu)
Small1
- Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. (rush.edu)
Active1
- Notably, VLL-28 is the first example of an archaeal antimicrobial peptide that is active towards Candida spp. (univr.it)
Infection1
- Drug target validation: lethal infection blocked by inducible peptide. (aaem.pl)
Properties1
- 2009. Antimicrobial polymers prepared by ring-opening metathesis polymerization: manipulating antimicrobial properties by organic counterion and charge density variation. . (umass.edu)
Minimal1
- To accomplish this, we used a metagenomics approach to characterize and compare the longitudinal wean-to-market resistome and microbiome of pigs challenged with PRRS virus and then exposed to different antimicrobial treatments, and a group of control pigs not challenged with PRRS virus and having minimal antimicrobial exposure. (biomedcentral.com)
Owing1
- Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry. (uni-koeln.de)
Circular1
- Circular dichroism results showed that C-terminus amidation maintains the structural stability of the peptide (α-helix) in contact with micelles. (edu.au)
Findings1
- According to NMR findings, the peptide is disordered in water, but assumes a peculiar torpedo-like structure in detergent micelles. (rcsb.org)
Significantly1
- Differences in ARG abundance between the groups were mostly driven by temporal changes in abundance that occurred prior to antimicrobial exposures, with the exception of erm G, which increased in the feces of treated pigs, and was significantly more abundant in the feces of these pigs compared to the pigs that did not receive post-PRRS antimicrobials. (biomedcentral.com)