Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Antimicrobial Cationic PeptidesPeptidesMagaininsPolymyxin BAnti-Bacterial AgentsDefensinsAnti-Infective AgentsCationsMicrobial Sensitivity Testsbeta-DefensinsHistatins
Antimicrobial Cationic Peptides
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Magainins
A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.
Polymyxin B
A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Defensins
Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.
Anti-Infective Agents
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Cations
Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
beta-Defensins
DEFENSINS found mainly in epithelial cells.
Histatins
A group of small, histidine-rich, cationic peptides in human SALIVA which are antibacterial and antifungal.

Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects. (1/2987)

Antibacterial glycopeptides isolated from insects are exciting bio-oligomers because they represent a family of compounds in which the structural and functional effects of incorporating short O-linked sugars to protein fragments can be studied. Additionally, their high activity in vitro warrants detailed further drug development efforts. Due to the limited availability of the isolated material, we used synthetic glycopeptides and some analogs to investigate the range of activity of drosocin and pyrrhocoricin. While addition of the Gal-GalNAc disaccharide to the natural mid-chain position generally increased the antibacterial activity of drosocin, pyrrhocoricin lacking sugar appeared to be more potent, with an IC50 against Escherichia coli D22 of 150 nM. Although glycosylated drosocin was active against E. coli in the low microM range in vitro, this peptide was completely inactive when injected into mice. The lack of in vivo activity of drosocin could be explained by the unusually high degradation rate of the peptides in mammalian sera. The early degradation products were inactive in vitro. In contrast, the peptides were considerably more stable in insect hemolymph, where their natural activity is manifested.  (+info)

Biological properties of structurally related alpha-helical cationic antimicrobial peptides. (2/2987)

A series of alpha-helical cationic antimicrobial peptide variants with small amino acid changes was designed. Alterations in the charge, hydrophobicity, or length of the variant peptides did not improve the antimicrobial activity, and there was no statistically significant correlation between any of these factors and the MIC for Pseudomonas aeruginosa, Escherichia coli, or Salmonella typhimurium. Individual peptides demonstrated synergy with conventional antibiotics against antibiotic-resistant strains of P. aeruginosa. The peptides varied considerably in the ability to bind E. coli O111:B4 lipopolysaccharide (LPS), and this correlated significantly with their antimicrobial activity and ability to block LPS-stimulated tumor necrosis factor and interleukin-6 production. In general, the peptides studied here demonstrated a broad range of activities, including antimicrobial, antiendotoxin, and enhancer activities.  (+info)

Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. (3/2987)

Positively charged antimicrobial peptides with membrane-damaging activity are produced by animals and humans as components of their innate immunity against bacterial infections and also by many bacteria to inhibit competing microorganisms. Staphylococcus aureus and Staphylococcus xylosus, which tolerate high concentrations of several antimicrobial peptides, were mutagenized to identify genes responsible for this insensitivity. Several mutants with increased sensitivity were obtained, which exhibited an altered structure of teichoic acids, major components of the Gram-positive cell wall. The mutant teichoic acids lacked D-alanine, as a result of which the cells carried an increased negative surface charge. The mutant cells bound fewer anionic, but more positively charged proteins. They were sensitive to human defensin HNP1-3, animal-derived protegrins, tachyplesins, and magainin II, and to the bacteria-derived peptides gallidermin and nisin. The mutated genes shared sequence similarity with the dlt genes involved in the transfer of D-alanine into teichoic acids from other Gram-positive bacteria. Wild-type strains bearing additional copies of the dlt operon produced teichoic acids with higher amounts of D-alanine esters, bound cationic proteins less effectively and were less sensitive to antimicrobial peptides. We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems.  (+info)

Recombinant bactericidal/permeability-increasing protein (rBPI21) in combination with sulfadiazine is active against Toxoplasma gondii. (4/2987)

The activity of recombinant bactericidal/permeability-increasing protein (rBPI21), alone or in combination with sulfadiazine, on the intracellular replication of Toxoplasma gondii was assessed in vitro and in mice with acute toxoplasmosis. rBPI21 markedly inhibited the intracellular growth of T. gondii in human foreskin fibroblasts (HFFs). Following 72 h of exposure, the 50% inhibitory concentration of rBPI21 for T. gondii was 2.6 micrograms/ml, whereas only slight cytotoxicity for HFF cells was observed at the concentrations tested. Subsequent mathematical analyses revealed that the combination of rBPI21 with sulfadiazine yielded slight to moderate synergistic effects against T. gondii in vitro. Infection of mice orally with C56 cysts or intraperitoneally (i.p.) with RH tachyzoites resulted in 100% mortality, whereas prolongation of the time to death or significant survival (P = 0.002) was noted for those animals treated with 5 to 20 mg of rBPI21 per kg of body weight per day. Treatment with rBPI21 in combination with sulfadiazine resulted in significant (P = 0.0001) survival of mice infected i.p. with tachyzoites but not of mice infected orally with T. gondii cysts. These results indicate that rBPI21 is active in vitro and in vivo against T. gondii and that its activity is significantly enhanced when it is used in combination with sulfadiazine. To our knowledge, this is the first report of the activity of rBPI21 against a protozoan parasite.  (+info)

In vitro antibacterial properties of pexiganan, an analog of magainin. (5/2987)

Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro broad-spectrum antibacterial activity when it was tested against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria. The pexiganan MIC at which 90% of isolates are inhibited (MIC90) was 32 micrograms/ml or less for Staphylococcus spp., Streptococcus spp., Enterococcus faecium, Corynebacterium spp., Pseudomonas spp., Acinetobacter spp., Stenotrophomonas spp., certain species of the family Enterobacteriaceae, Bacteroides spp., Peptostreptococcus spp., and Propionibacterium spp. Comparison of the MICs and minimum bactericidal concentrations (MBCs) of pexiganan for 143 isolates representing 32 species demonstrated that for 92% of the isolates tested, MBCs were the same or within 1 twofold difference of the MICs, consistent with a bactericidal mechanism of action. Killing curve analysis showed that pexiganan killed Pseudomonas aeruginosa rapidly, with 10(6) organisms/ml eliminated within 20 min of treatment with 16 micrograms of pexiganan per ml. No evidence of cross-resistance to a number of other antibiotic classes was observed, as determined by the equivalence of the MIC50s and the MIC90s of pexiganan for strains resistant to oxacillin, cefazolin, cefoxitin, imipenem, ofloxacin, ciprofloxacin, gentamicin, and clindamicin versus those for strains susceptible to these antimicrobial agents. Attempts to generate resistance in several bacterial species through repeated passage with subinhibitory concentrations of pexiganan were unsuccessful. In conclusion, pexiganan exhibits properties in vitro which make it an attractive candidate for development as a topical antimicrobial agent.  (+info)

A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. (6/2987)

We isolated SN-HLPf (Sambucus nigra hevein-like fruit protein), a hevein-like chitin-binding protein, from mature elderberry fruits. Cloning of the corresponding gene demonstrated that SN-HLPf is synthesized as a chimeric precursor consisting of an N-terminal chitin-binding domain corresponding to the mature elderberry protein and an unrelated C-terminal domain. Sequence comparisons indicated that the N-terminal domain of this precursor has high sequence similarity with the N-terminal domain of class I PR-4 (pathogenesis-related) proteins, whereas the C terminus is most closely related to that of class V chitinases. On the basis of these sequence homologies the gene encoding SN-HLPf can be considered a hybrid between a PR-4 and a class V chitinase gene.  (+info)

Endocytosis of heparin-binding protein (CAP37) is essential for the enhancement of lipopolysaccharide-induced TNF-alpha production in human monocytes. (7/2987)

Heparin-binding protein (HBP), also known as CAP37, is a proteolytically inactive serine protease homologue that is released from activated granulocytes. However, HBP is not a biologically inactive molecule but rather a multifunctional protein with properties that include the enhancement of LPS-induced TNF-alpha production from monocytes. We have previously demonstrated that HBP is internalized in monocytes. In the current study, we hypothesize that HBP is internalized in monocytes via endocytosis, and this internalization is an important mechanism by which HBP enhances LPS-induced TNF-alpha release. Using whole blood from healthy donors and flow cytometry, we found that colchicine (0.1-10 mM), cytochalasin D (1000 microM), NH4Cl (10-50 mM), and bafilomycin A1 (0.1-3 microM) significantly reduced the affinity of FITC-HBP for CD14-positive monocytes. Using isolated human monocytes and ELISA, we found that colchicine (0.1 mM), cytochalasin D (30 and 300 microM), NH4Cl (30 mM), and bafilomycin A1 (1 microM) significantly reduced the effect of HBP (10 microg/ml) to enhance LPS (10 ng/ml)-induced TNF-alpha release after 24 h. These findings demonstrate that internalization of HBP in monocytes is essential for the enhancement of LPS-induced TNF-alpha release. Transport of HBP to an activating compartment depends on intact F-actin polymerization and endosomal acidification, an important mechanism for endosomal protein sorting and trafficking.  (+info)

Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. (8/2987)

Recent studies suggest that the gene defect in cystic fibrosis (CF) leads to a breach in innate immunity. We describe a novel genetic strategy for reversing the CF-specific defect of antimicrobial activity by transferring a gene encoding a secreted cathelicidin peptide antibiotic into the airway epithelium grown in a human bronchial xenograft model. The airway surface fluid (ASF) from CF xenografts failed to kill Pseudomonas aeruginosa or Staphylococcus aureus. Partial reconstitution of CF transmembrane conductance regulator expression after adenovirus-mediated gene transfer restored the antimicrobial activity of ASF from CF xenografts to normal levels. Exposure of CF xenografts to an adenovirus expressing the human cathelicidin LL-37/hCAP-18 increased levels of this peptide in the ASF three- to fourfold above the normal concentrations, which were equivalent in ASF from CF and normal xenografts before gene transfer. The increase of LL-37 was sufficient to restore bacterial killing to normal levels. The data presented describe an alternative genetic approach to the treatment of CF based on enhanced expression of an endogenous antimicrobial peptide and provide strong evidence that expression of antimicrobial peptides indeed protects against bacterial infection.  (+info)

Improvement of outer membrane-permeabilizing and lipopolysaccharide- binding activities of an antimicrobial cationic peptide by...
TY - JOUR. T1 - Improvement of outer membrane-permeabilizing and lipopolysaccharide- binding activities of an antimicrobial cationic peptide by C-terminal modification. AU - Piers, K. L.. AU - Brown, M. H.. AU - Hancock, Robert. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Antimicrobial cationic peptides have been discovered in many different organisms and often possess a broad range of activity. In this study, we investigated the mechanisms of actions of melittin and two synthetic peptides, CEME (a cecropin-melittin hybrid) and CEMA, against gram-negative bacteria. CEMA was produced by recombinant DNA procedures and is an analog of CEME with a modified C terminus resulting in two additional positive charges. All three peptides showed good antimicrobial activity against four different gram-negative bacteria, but only CEMA was able to somewhat augment the activity of some conventional antibiotics in synergy studies. Studies using the bacteria Pseudomonas aeruginosa and Enterobacter cloacae showed that the ...
https://portal.sahmriresearch.org/en/publications/improvement-of-outer-membrane-permeabilizing-and-lipopolysacchari
ANTIMICROBIAL POLYPEPTIDES - Patent applicationANTIMICROBIAL POLYPEPTIDES - Patent application
114118PRTArtificial SequenceSynthetic antimicrobial polypeptide 1Lys Asn Leu Arg Arg Ile Ile Arg Lys Gly Ile His Ile Ile Lys Lys1 5 10 15Tyr Gly218PRTArtificial SequenceSynthetic antimicrobial polypeptide 2Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa1 5 10 15Xaa Xaa318PRTArtificial SequenceSynthetic antimicrobial polypeptide 3Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa1 5 10 15Xaa Xaa418PRTArtificial SequenceSynthetic antimicrobial polypeptide 4Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa1 5 10 15Xaa Xaa518PRTArtificial SequenceSynthetic antimicrobial polypeptide 5Lys Gly Leu Arg Arg Ile Ile Arg Lys Gly Ile His Ile Ile Lys Lys1 5 10 15Tyr Gly618PRTArtificial SequenceSynthetic antimicrobial polypeptide 6Lys Gly Leu Arg Arg Ile Ile Arg Trp Gly Ile His Ile Ile Lys Lys1 5 10 15Tyr Gly718PRTArtificial SequenceSynthetic antimicrobial polypeptide 7Lys Ile Leu Arg Arg Ile Ile Arg Lys Gly Ile His Ile Ile Lys Lys1 5 10 15Tyr Gly818PRTArtificial ...
http://www.patentsencyclopedia.com/app/20090137481
Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37 | The Journal of...Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37 | The Journal of...
This study conclusively demonstrates that endotoxin-induced inflammatory gene responses and cytokine secretion in monocytes were suppressed by low, physiological concentrations of LL-37, implicating LL-37 in the regulation and control of proinflammatory responses associated with pathogenic assault and, by extension, with homeostatic levels of TLR agonists secreted by commensals. This report further demonstrates that LL-37 can suppress LPS-induced NF-κB translocation and exert an anti-inflammatory effect that is not restricted to endotoxin-induced inflammation. In the human THP-1 monocytic cell line as well as in human PBMC, LL-37 suppressed proinflammatory cytokine production induced by LPS as well as other agonists of TLR2 (LTA, Pam3CSK4) and in part TLR9 (CpG), but selectively enhanced responses to the proinflammatory cytokines IL-1β and TNF-α. Selective enhancement of responses is consistent with the known complex interaction of LL-37 with cells (20, 38), including the induction of a ...
https://www.jimmunol.org/content/176/4/2455?ijkey=4f326273c5b0f18a786497332fee8ae1c7c3332f&keytype2=tf_ipsecsha
The Human Host Defense Peptide LL-37 Induces Caspase-independent Apoptosis Via Apoptosis-Inducing Factor And Endonuclease G in...The Human Host Defense Peptide LL-37 Induces Caspase-independent Apoptosis Via Apoptosis-Inducing Factor And Endonuclease G in...
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https://aims.cuhk.edu.hk/converis/portal/detail/Publication/19629474?auxfun=&lang=en_GB
Defensins and other antimicrobial peptides and proteins<...
TY - CHAP. T1 - Defensins and other antimicrobial peptides and proteins. AU - Lehrer, Robert I.. AU - Bevins, Charles L. AU - Ganz, Tomas. PY - 2005. Y1 - 2005. N2 - Endogenous antimicrobial peptides are widely distributed among vertebrates. Most are amphiphilic, polycationic molecules with an α-helical, cystine-stabilized β-sheet, or proline-rich structure. Secreted and cell-associated antimicrobial peptides enable their hosts to resist incursions by potential pathogens. Such peptides present a series of barriers to the pathogens, to evade or overcome. In humans (and other mammals), defensins and cathelicidins are the principal antimicrobial peptides of neutrophils and epithelial cells. Many mucosal surfaces are bathed by antimicrobial proteins, including lysozyme, lactoferrin, secretory leukoprotease inhibitor (SLPI), and secretory phospholipase A2. All defensins have largely β-sheet structure and contain three intramolecular cystine disulfide bonds. The smallest, .-defensins, are circular ...
https://ucdavis.pure.elsevier.com/en/publications/defensins-and-other-antimicrobial-peptides-and-proteins
A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. - Semantic ScholarA novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. - Semantic Scholar
PURPOSE Antimicrobial peptides (AMPs) are cationic host defense peptides with microbicidal and cell-signaling properties. They show promise as potential therapeutic agents. In the present study, a beta-defensin AMP gene was isolated from the ocular surface for the first time, and its expression was characterized in the presence of ocular inflammation and/or infection. METHODS Total RNA was obtained from impression cytology samples of the conjunctiva and cornea of normal patients and of those with bacterial, viral, acanthamoeba, or dry eye disease. The expression of the beta-defensin AMP DEFB-109 was determined by using reverse transcription-polymerase chain reaction (RT-PCR). Relative quantification of the gene in the various groups was performed by means of real-time PCR. RESULTS DEFB-109 was constitutively expressed in all samples. The gene showed significantly decreased expression in the presence of all types of inflammation/infection. Reduced expression featured most prominently in acanthamoeba
https://www.semanticscholar.org/paper/A-novel-antimicrobial-peptide-on-the-ocular-surfac-Abedin-Mohammed/4d1cb4424ce1df4ef89435248231da1bd6841233
Cationic host defence peptides: multifaceted role in immune modulation and inflammation. - PubMed - NCBICationic host defence peptides: multifaceted role in immune modulation and inflammation. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/22739631?dopt=Abstract
Patente WO1994018323A1 - Stable bactericidal/permeability-increasing protein products and ... - Google PatentesPatente WO1994018323A1 - Stable bactericidal/permeability-increasing protein products and ... - Google Patentes
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.
http://www.google.es/patents/WO1994018323A1?cl=en
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Barlow, P. G., Li, Y., Wilkinson, T. S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., …Davidson, D. J. (2005). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology. 80, 509-520. doi:10.1189/jlb.1005560. ISSN 0741-5400. ...
https://www.napier.ac.uk/research-and-innovation/research-search?q=Exploring+the+effects+of+stress+history+on+the+drained+and+undrained+cyclic+behaviour+of+granular+materials&fv=D6705B99CAD14C8F9D206EF0FB9B53AB~Centre+for+Nano+Safety&tab=3
Explore our researchExplore our research
Barlow, P. G., Li, Y., Wilkinson, T. S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., …Davidson, D. J. (2005). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. Journal of Leukocyte Biology. 80, 509-520. doi:10.1189/jlb.1005560. ISSN 0741-5400. ...
https://www.napier.ac.uk/research-and-innovation/research-search?q=Exploring+the+effects+of+stress+history+on+the+drained+and+undrained+cyclic+behaviour+of+granular+materials&fv=D6705B99CAD14C8F9D206EF0FB9B53AB~Centre+for+Nano+Safety&tab=2
Regulation of antimicrobial peptide gene expression by nutrients and byproducts of microbial metabolism
Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs bind lipopolysaccharides, act as chemoattractants for immune cells and bind to cellular receptors and modulate the expression of cytokines and chemokines. These additional biological activities may explain the role of AMPs in inflammatory diseases and cancer. Modulating the endogenous expression of AMPs offers potential therapeutic treatments for infection and disease. Methods: The present review examines published data from both in vitro and in vivo studies reporting effects of nutrients and byproducts of microbial metabolism on the expression of antimicrobial peptide genes in order to highlight an emerging appreciation for the role of ...
https://ir.library.oregonstate.edu/concern/defaults/bg257f798
Sequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide - SoligenixSequestosome-1/p62 Is the Key Intracellular Target of Innate Defense Regulator Peptide - Soligenix
Yu HB, Kielczewska A, Rozek A, Takenaka S, Li Y, Thorson L, et al. Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide. J Biol Chem. 2009;284,36007-11.. Learn More ...
https://www.soligenix.com/blog/resource/sequestosome-1-p62-is-the-key-intracellular-target-of-innate-defense-regulator-peptide/
Pharmaceuticals | Free Full-Text | Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications | HTMLPharmaceuticals | Free Full-Text | Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications | HTML
Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomoduatory properties. Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and therefore, are being actively investigated as a novel class of antimicrobials and vaccine adjuvants. Cathelicidins and β-defensins are two major families of HDPs in avian species. More than a dozen HDPs exist in birds, with the genes in each HDP family clustered in a single chromosomal segment, apparently as a result of gene duplication and diversification. In contrast to their mammalian counterparts that adopt various spatial conformations, mature avian cathelicidins are mostly α-helical. Avian β-defensins, on the other hand, adopt triple-stranded β-sheet structures similar to their mammalian relatives. Besides classical β-defensins, a group of avian-specific β-defensin-related peptides, namely ovodefensins, exist with a different six-cysteine motif. Like
http://mdpi.com/1424-8247/7/3/220/htm
Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in | proLékaře.czCombined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in | proLékaře.cz
1. SteinerH, HultmarkD, EngstromA, BennichH, BomanHG (1981) Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248.. 2. ZasloffM (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci USA 84: 5449-5453.. 3. GanzT, SelstedME, LehrerRI (1990) Defensins. Eur J Haematol 44: 1-8.. 4. BrogdenKA (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature Rev Microbiol 3: 238-250.. 5. HancockREW, SahlH-G (2006) Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nature Biotech 24: 1551-1557.. 6. PeschelA, SahlH-G (2006) The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nature Rev Microbiol 4: 529-536.. 7. HaleJDF, HancockREW (2007) Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev Anti Infect Ther ...
https://www.prolekare.cz/casopisy/plos-pathogens/2014-5/combined-systems-approaches-reveal-highly-plastic-responses-to-antimicrobial-peptide-challenge-in-53597
Activity of antimicrobial peptides and 25-hydroxycholecalciferol in children with asthma - medexpert
National Pirogov Memorial Medical University, Vinnytsya, Ukraine Purpose - to determine the activity of antimicrobial peptides, such as cathelicidin LL-37 and 25-hydroxycholecalciferol in children with asthma. Materials and methods. We have comprehensively examined 200 children with asthma aged 6 to 17 years. The contents of 25(OH)D3 and cathelicidin LL-37 in serum were determined by ELISA according to the instructions of the manufacturer. Results. The examination revealed that the total content of 25(OH)D3 in the serum of children with asthma differs from the values of healthy children and characterized by a significant decrease of its level (p,0.01). Concentration of cathelicidin LL-37 in patients with asthma was significantly higher (p,0.001), than in the group of healthy children. The positive correlation between the cathelicidin LL-37, interleukin 1 (rxy=0.398 (p=0.02)) and interleukin 6 (rxy=0.178 (p=0.034)) in children with asthma was determined. The concentration of cathelicidin LL-37 in ...
http://med-expert.com.ua/en/activity-of-antimicrobial-peptides-and-25-hydroxycholecalciferol-in-children-with-asthma/
Gamma AApeptides as Host Defense Peptide Mimics by Yaqiong LiGamma AApeptides as Host Defense Peptide Mimics by Yaqiong Li
There has been increasing concern regarding the emergence of multi-drug resistant pathogens. The resistance develops when pathogens, especially bacteria, are frequently exposed to conventional antibiotics, as they are heavily used in both human and livestock. This is due to the high target specificity of conventional antibiotics, which places pathogens in high selective pressures and eventually results in drug resistant by mutations. To address this issue, global actions and cooperation are needed. At the same time, new technologies and strategies need to be developed. Host defense peptides (HDPs) are widely found in the innate immune system. They show both direct antimicrobial properties and immunomodulatory activities. The multifaceted functions of HPDs make them less likely to promote antimicrobial resistance. Thus, they are promising as new therapeutics to treat multi-drug resistant infections. In fact, several drug candidates derived from HDPs have entered the clinical trial, but none of them got
http://scholarcommons.usf.edu/etd/6301/
Roles of d-Amino Acids on the Bioactivity of Host Defense PeptidesRoles of d-Amino Acids on the Bioactivity of Host Defense Peptides
Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs.. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:1033502
Dr Donald J Davidson | The University of Edinburgh
Donald J Davidsons lab studies the role of cationic host defence peptides (antimicrobial peptides) as modulators of cell death, inflammation and immunity in infectious and inflammatory lung diseases, and innate immune signalling.
https://www.ed.ac.uk/inflammation-research/people/principal-investigators/dr-donald-j-davidson
Using anti-biofilm peptides to treat antibiotic-resistant bacterial infectionsUsing anti-biofilm peptides to treat antibiotic-resistant bacterial infections
Host defense (antimicrobial) peptides (HDPs) are produced by virtually all organisms and have an important role in protection against microbial infections. Some naturally occurring peptides such as the human cathelicidin LL-37 and the bovine peptide indolicidin have been shown to inhibit bacterial b …
https://pubmed.ncbi.nlm.nih.gov/27563687/
Welcome to the APD3
This comprehensive database for antimicrobial peptides is manually curated based on a set of data-collection criteria. There are 139 human host defense peptides, 305 from mammals annotated, 1087 active peptides from amphibians (1018 from frogs), 134 fish peptides, 45 reptile peptides, 42 from birds, 559 from arthropods, [310 from insects, 69 from crustaceans, 7 from myriapods, 171 from chelicerata, (43 from spiders, 88 from scorpions)], 45 from molluscs, 6 AMPs from protozoa, and more. Of the 428 unique NMR/X-ray diffracted 3D structures annotated for host defense peptides in the APD, 301 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian α-helical magainin II; Top right: bovine β-sheet lactoferricin; Bottom left: plant αβ-PsD1; Bottom right: bovine non-αβ indolicidin. This original database consists of a pipeline of search functions for innate immune peptides. You can search for peptide information using APD ID, ...
http://aps.unmc.edu/AP/main.php/database/database/timeline.php
Welcome to the APD3
This comprehensive database for antimicrobial peptides is manually curated based on a set of data-collection criteria. There are 141 human host defense peptides, 328 from mammals annotated, 1117 active peptides from amphibians (1037 from frogs and 76 from toads), 136 fish peptides, 45 reptile peptides, 43 from birds, 577 from arthropods, [323 from insects, 71 from crustaceans, 8 from myriapods, 175 from chelicerata, (43 from spiders, 88 from scorpions)], 47 from molluscs, 6 AMPs from protozoa, and more. Of the 443 unique NMR/X-ray diffracted 3D structures annotated for host defense peptides in the APD, 316 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian α-helical magainin II; Top right: bovine β-sheet lactoferricin; Bottom left: plant αβ-PsD1; Bottom right: bovine non-αβ indolicidin. This original database consists of a pipeline of search functions for innate immune peptides. You can search for peptide information ...
http://aps.unmc.edu/AP/main.php/design/database/statistic/statistic_main.php
中国科学院动物研究所机构知识库(CAS OpenIR): Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or...中国科学院动物研究所机构知识库(CAS OpenIR): Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or...
Zhu SY,Gao B. Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or Endogenous Receptors?[J]. Heredity,2017,118(5):453-465 ...
http://ir.ioz.ac.cn/handle/000000/12944
Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. - PubMed - NCBIAlternative mechanisms of action of cationic antimicrobial peptides on bacteria. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/18039080?dopt=Abstract
Exploring the Activity Space of Multifaceted Host Defence Peptides | UBC ChemistryExploring the Activity Space of Multifaceted Host Defence Peptides | UBC Chemistry
Host defence peptides (HDPs) are polypeptide sequences found ubiquitously in nature that have garnered significant attention as alternatives to antibiotics. Originally appreciated for their direct antibacterial effect, recent work has revealed that many HDPs possess antibiofilm activity, anticancer activity and/or the ability to modulate the immune response of the host.
http://www.chem.ubc.ca/exploring-activity-space-multifaceted-host-defence-peptides-0
Eduardo Cobo | Cobo Lab | Calgary | Cathelicidin | Host defense peptidesEduardo Cobo | Cobo Lab | Calgary | Cathelicidin | Host defense peptides
Eduardo R. Cobo Scientific laboratory (University of Calgary) studying innate immune functions of epithelial cells and leukocytes contributed by host defense peptides.
https://www.cobolab.com/
Next generation of de novo designed amphipathic α-helical antimicrobial peptides to treat the gram-negative pathogen,...Next generation of de novo designed amphipathic α-helical antimicrobial peptides to treat the gram-negative pathogen,...
Biotechnology Conferences 2020 Rome and Bioengineering Conferences 2020 Rome are accredited scientific conferences scheduled in 2020 during June 18-20 is international biotechnology experts gathering
https://biotechnology-conferences.magnusgroup.org/program/scientific-program/next-generation-of-de-novo-designed-amphipathic-helical-antimicrobial-peptides-to-treat-the-gram-negative-pathogen-acinetobacter-baumannii
Indolicidin Stabilizes Duplex DNA and Prevents DNA Replication and Transcription - AAPPTECIndolicidin Stabilizes Duplex DNA and Prevents DNA Replication and Transcription - AAPPTEC
Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy.. Ghosh A, Kar RK, Jana J, Saha A, Jana B, Krishnamoorthy J, Kumar D, Ghosh S, Chatterjee S, Bhunia A, ChemMedChem, 2014, 9, 2052-8.. Indolicidin (IR13), a 13-residue antimicrobial peptide from the cathelicidin family, is known to exhibit a broad spectrum of antimicrobial activity against various microorganisms. This peptide inhibits bacterial DNA synthesis resulting in cell filamentation. However, the precise mechanism remains unclear and requires further investigation. The central PWWP motif of IR13 provides a unique structural element that can wrap around, and thus stabilize, duplex B-type DNA structures. Replacements of the central Trp-Trp pair with Ala-Ala, His-His, or Phe-Phe residues in the PxxP motif significantly affects the ability of the peptide to stabilize duplex DNA. Results of microscopy studies in conjunction with spectroscopic data confirm that the DNA duplex ...
https://www.peptide.com/2014/10/01/indolicidin-stabilizes-duplex-dna-and-prevents-dna-replication-and-transcription/
Antimicrobial peptides | DermNet NZAntimicrobial peptides | DermNet NZ
Antimicrobial peptides, Cationic antimicrobial peptides, Cathelicidins, Defensins, Host defence peptides, Microbicidal cationic proteins. Authoritative facts from DermNet New Zealand.
https://www.dermnetnz.org/topics/antimicrobial-peptides/
Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs | GMR | Genetics and...Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs | GMR | Genetics and...
The bactericidal/permeability-increasing protein (BPI) gene has been identified as a candidate gene for disease-resistance breeding. We evaluated whether polymorphisms in exons 4 and 10 of the BPI gene are associated with immune indices [interleukin-2 (IL-2), IL-4, IL-6, interferon-b (IFN-b), IL-10, and IL-12]. In this study, we identified one mutation (C522T) in the BPI exon 4 site and two mutations (A1060G and T1151G) in the BPI exon 10 site.
https://geneticsmr.com/articles/4524
ARTICLES | Journal of Applied Physiology
Bactericidal/permeability-increasing protein (BPI), a cationic protein isolated from human neutrophils, binds lipopolysaccharide (LPS), kills gram-negative bacteria, and neutralizes many of the effects of LPS in vitro and in vivo. We hypothesized that a recombinant 23-kDa NH2-terminal fragment of BPI (BPI23) would reduce acute lung injury in endotoxemic pigs. At -18 h, pigs received an intravenous priming dose of LPS (20 micrograms/kg). Anesthetized ventilated swine were randomized to receive 1) no further treatment (n = 4); 2) LPS (250 micrograms/kg over 50 min) and BPI23 (3-mg/kg bolus and 3 mg/kg over 60 min) (n = 6); or 3) LPS and thaumatin, a cationic protein devoid of LPS neutralizing activity that has a molecular mass and isoelectric point that are similar to that of BPI23 (n = 7). BPI23 treatment significantly ameliorated LPS-induced hypoxemia, functional upregulation of opsonin receptors on circulating phagocytes, and alveolitis but had no effect on the elaboration of tumor necrosis ...
http://jap.physiology.org/content/76/5/2006.long
Polymorphisms of candidate genes associated with meat quality and disease resistance in indigenous and exotic pig breeds of...Polymorphisms of candidate genes associated with meat quality and disease resistance in indigenous and exotic pig breeds of...
CUONG, Ng.V. et al. Polymorphisms of candidate genes associated with meat quality and disease resistance in indigenous and exotic pig breeds of Vietnam. S. Afr. j. anim. sci. [online]. 2012, vol.42, n.3, pp.221-231. ISSN 2221-4062.. The objectives of this study were to analyse genotype distribution and sequence variations of candidate genes putatively associated with meat quality and disease resistance in exotic and indigenous Vietnamese pig breeds. For this purpose, 340 pigs from four indigenous and two exotic breeds were included in the analysis of the polymorphisms of the heart fatty-acid-binding protein (H-FABP), alpha 1 fucosyltransferase (FUT1), and bactericidal/permeability-increasing protein (BPI) genes by the sequencing and PCR-RFLP methods. For H-FABP, 17 single nucleotide polymorphisms (SNPs) were detected in indigenous pig breeds by direct sequencing of a fragment at intron 2 of the H-FABP gene. The mutation T1556C created a new restriction site for the enzyme MspI, which gave rise ...
http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0375-15892012000300003&lng=pt&nrm=iso&tlng=en
Antimicrobial peptides in action | Research | University of GroningenAntimicrobial peptides in action | Research | University of Groningen
Antimicrobial peptides (AMPs) exhibit a wide range of antimicrobial and antifungal activity and have attracted significant interest as potential antibiotics. However, the mechanism of action of antimicrobial peptides is still poorly understood and, from experimental data, different membrane disruption structural models have been proposed for linear α-helical peptides (the barrel-stave and the toroidal pore models).. We investigate the mechanisms of AMPs in action at different levels of detail: from atomistic [1, 2] to coarse grained molecular dynamics (MD) simulations [3, 4] and even at mixed detail between the two [5]. We proposed a new mechanism for membrane poration by linear antimicrobial peptides: the disordered toroidal pore [1, 2]. Besides, we were able to provide detailed insight on the mechanism of pore-forming cyclic peptides in an effort that brought together simulation results and in vitro measurements of peptide activity [6].. [1] H. Leontiadou, A.E. Mark, S.J. Marrink. ...
https://www.rug.nl/research/molecular-dynamics/research/antimicrobial-peptides-in-action?lang=en
High-Dose Vitamin D and Antimicrobial Peptide Expression in Lung Failure - Gregory MartinHigh-Dose Vitamin D and Antimicrobial Peptide Expression in Lung Failure - Gregory Martin
This application is in response to PA-09-164 (NIH Exploratory Developmental Research Grant Program). Given the high rate of hospital-acquired infection in criti...
http://grantome.com/grant/NIH/R21-HL110044-02
Developmental switch of intestinal antimicrobial peptide expression | JEMDevelopmental switch of intestinal antimicrobial peptide expression | JEM
Sandrine Ménard, Valentina Förster, Michael Lotz, Dominique Gütle, Claudia U. Duerr, Richard L. Gallo, Birgitta Henriques-Normark, Katrin Pütsep, Mats Andersson, Erik O. Glocker, Mathias W. Hornef ...
http://jem.rupress.org/content/early/2008/01/07/jem.20071022
Versatile interactions of the antimicrobial peptide novispirin with detergents and lipids - Aalborg Universitets...Versatile interactions of the antimicrobial peptide novispirin with detergents and lipids - Aalborg Universitets...
TY - CONF. T1 - Versatile interactions of the antimicrobial peptide novispirin with detergents and lipids. AU - Wimmer, Reinhard. AU - Andersen, Kell. AU - Davidsen, Mads. AU - Mølgaard, Søren. AU - Nesgaard, Lise. AU - Kristensen, Hans Henrik. AU - Vad, Brian. AU - Otzen, Daniel. PY - 2006. Y1 - 2006. M3 - Paper without publisher/journal. Y2 - 20 August 2006 through 26 August 2006. ER - ...
https://vbn.aau.dk/da/publications/versatile-interactions-of-the-antimicrobial-peptide-novispirin-wi
Ebook Mammalian host defense peptides Download PDF EPUB FB2
Studies of the regulation of antimicrobial peptide synthesis in Drosophila have been particularly fruitful, providing new directions for the analysis of mammalian host defense HN2. Although antimicrobial peptides display a variety of shapes and amino acid compositions, many of those found in vertebrates are defensins HN3, 3- to 6-kD β-sheet Cited by:
https://rytelumisy.siyamiozkan.com/mammalian-host-defense-peptides-book-6140zo.php
DUGi: Ítem | Recercat - Antimicrobial peptide genes in Bacillus strains from plant environmentsDUGi: Ítem | Recercat - Antimicrobial peptide genes in Bacillus strains from plant environments
DUGi: Viewing Item from repository Recercat: The presence of the antimicrobial peptide (AMP) biosynthetic genes srfAA (surfactin), bacA (bacylisin), fenD (fengycin), bmyB (bacyllomicin), spaS (subtilin), and ituC (iturin) was examined in 184 isolates of Bacillus spp. obtained from plant environments (aerial, rhizosphere, soil) in the Mediterranean land area of Spain. Most strains had between two and four AMP genes whereas strains with five genes were seldom detected and none of the strains had six genes. The most frequent AMP gene markers were srfAA, bacA, bmyB, and fenD, and the most frequent genotypes srfAA-bacA-bmyB and srfAAbacA-bmyB-fenD. The dominance of these particular genes in Bacillus strains associated with plants reinforces the competitive role of surfactin, bacyllomicin, fengycin, and bacilysin in the fitness of strains in natural environments. The use of these AMP gene markers may assist in the selection of putative biological control agents of plant pathogens
http://dugi.udg.edu/item/http:@@@@[email protected]@[email protected]@210738
Custom-Designed Anti-Microbial Peptides | MedgadgetCustom-Designed Anti-Microbial Peptides | Medgadget
A method pioneered by MIT researchers might offer hope in finding a new generation of antibiotics, made of antimicrobial peptides. Antimicrobial peptides a
https://www.medgadget.com/2006/10/customdesigned.html
Pharmaceuticals | Free Full-Text | Antimicrobial Peptides from FishPharmaceuticals | Free Full-Text | Antimicrobial Peptides from Fish
Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species, the fish peptides exhibit broad-spectrum antimicrobial activity, killing both fish and human pathogens. They are also immunomodulatory, and their genes are highly responsive to microbes and innate immuno-stimulatory molecules. Recent research has demonstrated that some of the unique properties of fish peptides, including their ability to act even in very high salt concentrations, make them good potential targets for development as therapeutic antimicrobials. Further, the stimulation of their gene expression by exogenous factors could be useful in preventing pathogenic microbes in aquaculture.
http://www.mdpi.com/1424-8247/7/3/265
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activityA new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
Background Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could be cytotoxic to the producer cell, and if small they can be easily degraded. The objective of this study was to produce a multidomain antimicrobial protein based on recombinant protein nanoclusters to increase the yield, stability and effectivity. Results A single antimicrobial polypeptide JAMF1 that combines three functional domains based on human α-defensin-5, human XII-A secreted phospholipase A2 (sPLA2), and a gelsolin-based bacterial-binding domain along with two aggregation-seeding domains based on leucine zippers was successfully produced with no toxic effects for the producer cell and mainly in a nanocluster structure. Both, the nanocluster and solubilized format of the protein showed a clear antimicrobial effect against a broad spectrum of Gram-negative and Gram-positive bacteria, ...
https://repositori.irta.cat/handle/20.500.12327/846
Hepcidin (Liver Expressed Antimicrobial Peptide 1 or Putative Liver Tumor Regressor or HAMP) - Pipeline Review, H2 2016Hepcidin (Liver Expressed Antimicrobial Peptide 1 or Putative Liver Tumor Regressor or HAMP) - Pipeline Review, H2 2016
Hepcidin (Liver Expressed Antimicrobial Peptide 1 or Putative Liver Tumor Regressor or HAMP) - Pipeline Review, H2 2016 Hepcidin (Liver Expressed Antimicrobial Peptide 1 or - Market research report and industry analysis - 10290125
https://www.marketresearch.com/Global-Markets-Direct-v3480/Hepcidin-Liver-Expressed-Antimicrobial-Peptide-10290125/
Publications
abstract = {The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities are synthesized by the fat body during the immune response and secreted into the hemolymph. Using GFP reporter transgenes, we show here that all seven Drosophila antimicrobial peptides can be induced in surface epithelia in a tissue-specific manner. The imd gene plays a critical role in the activation of this local response to infection. In particular, drosomycin expression, which is regulated by the Toll pathway during the systemic response, is regulated by imd in the respiratory tract, thus demonstrating the existence of distinct regulatory mechanisms for local and systemic induction of antimicrobial peptide genes in Drosophila ...
https://ibmc-m3i.cnrs.fr/fr/publications/?tgid=888
Azurocidin - inactive serine proteinase homolog acting as a multifunctional inflammatory mediator. - Acta Biochimica Polonica -...
Azurocidin, also known as cationic antimicrobial protein 37 kDa (CAP37) or heparin-binding protein (HBP) is an inactive homolog of serine proteinases residing in granulocytes. The ability to cleave peptide bond was lost due to replacement of two of the three residues from the conserved catalytic triad characteristic for serine proteinases. Azurocidin has a broad spectrum of antimicrobial activity, mainly against Gram-negative bacteria. It is also recognized as a multifunctional inflammatory mediator for its contracting effects on endothelial cells causing an increase of vascular permeability, capacity to bind endotoxin and ability to attract monocytes to inflammation sites ...
http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.bwnjournal-article-abpv50i3p743kz
Host Defense Peptides and the New Line of Defence Against Multire...: Ingenta ConnectHost Defense Peptides and the New Line of Defence Against Multire...: Ingenta Connect
Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function ...
https://www.ingentaconnect.com/contentone/ben/ppl/2008/00000015/00000003/art00001
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted...
TY - JOUR. T1 - Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives. AU - Conlon, J. Michael. AU - Abraham, Bency. AU - Galadari, Sehamuddin. AU - Knoop, Floyd C.. AU - Sonnevend, Agnes. AU - Pál, Tibor. PY - 2005/11/1. Y1 - 2005/11/1. N2 - Kassinatuerin-1, a 21-amino-acid C-terminally α-amidated peptide first isolated from the skin of the African frog Kassina senegalensis, adopts an amphipathic α-helical conformation in a membrane-mimetic solvent (50% trifluoroethanol) and shows broad-spectrum antimicrobial activity. However, its therapeutic potential is limited by its relatively high cytolytic activity against mammalian cells. The antimicrobial and cytolytic properties of a peptide are determined by an interaction between cationicity, hydrophobicity, α-helicity and amphipathicity. Replacement of the C-terminal α-amide group in kassinatuerin-1 by carboxylic acid decreased both cationicity and α-helicity, ...
https://creighton.pure.elsevier.com/en/publications/antimicrobial-and-cytolytic-properties-of-the-frog-skin-peptide-k
தவளைகளிடமிருந்து வைரஸ் காய்ச்சலை தடுக்கும் மருந்துகள் - நவீன அறிவியல்தவளைகளிடமிருந்து வைரஸ் காய்ச்சலை தடுக்கும் மருந்துகள் - நவீன அறிவியல்
சளிப்படலம் போன்ற ஒரு வண்ணமயமான திரவத்தினை சுரக்கும் தவளையானது (ஹைட்ரோஃபிளாஸ் பேஹுவிஸ்தாரா)( Hudrophylax bahuvistara) கேளராவில் கண்டுபிடிக்கப்பட்டு உள்ளது. தவளையின் தோலிலிருந்து வெளிப்படும் பிசுப்பிசுப்பான திரவத்தினை ஆய்வு செய்ததில் host defence peptides இருப்பது கண்டுபிடிக்கப்பட்டு உள்ளது. இந்த புதிய பெப்டைட்களுக்கு உருமின் என்று கேரளாவின் உறுமி வாளை நினைவுபடுத்தும் வகையில் பெயர்
https://naveenaariviyal.wordpress.com/2017/04/21/%E0%AE%A4%E0%AE%B5%E0%AE%B3%E0%AF%88%E0%AE%95%E0%AE%B3%E0%AE%BF%E0%AE%9F%E0%AE%AE%E0%AE%BF%E0%AE%B0%E0%AF%81%E0%AE%A8%E0%AF%8D%E0%AE%A4%E0%AF%81-%E0%AE%B5%E0%AF%88%E0%AE%B0%E0%AE%B8%E0%AF%8D-%E0%AE%95/
Nanomechanical response of bacterial cells to cationic antimicrobial peptides - Soft Matter (RSC Publishing)Nanomechanical response of bacterial cells to cationic antimicrobial peptides - Soft Matter (RSC Publishing)
The effectiveness of antimicrobial compounds can be easily screened, however their mechanism of action is much more difficult to determine. Many compounds act by compromising the mechanical integrity of the bacterial cell envelope, and our study introduces an AFM-based creep deformation technique to evaluate Interaction of nano-objects with lipid membranes
http://pubs.rsc.org/en/content/articlelanding/2014/sm/c3sm52801d/unauth
Publications
abstract = {The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat body. The defence against Gram-positive bacteria and natural fungal infections is mediated by the Toll signalling pathway, whereas defence against Gram-negative bacteria is dependent on the Immune deficiency (IMD) pathway. Loss-of-function mutations in either pathway reduce the resistance to corresponding infections. The link between microbial infections and activation of these two pathways has remained elusive. The Toll pathway is activated by Gram-positive bacteria through a circulating Peptidoglycan recognition protein (PGRP-SA). PGRPs appear to be highly conserved from insects to mammals, and the Drosophila genome contains 13 members. Here we report a mutation in a gene coding for a putative transmembrane protein, PGRP-LC, which reduces survival to Gram-negative sepsis but has no effect on the response to Gram-positive bacteria or ...
https://ibmc-m3i.cnrs.fr/fr/publications/?tgid=735
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis...Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis...
The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic α-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Understanding its mode of action may assist in the development of antimicrobial agents mimicking those of the human immune system. In vitrostudies revealed that LL-37 is cytotoxic to both bacterial and normal eukaryotic cells. To gain insight into the mechanism of its non-cell-selective cytotoxicity, we synthesized and structurally and functionally characterized LL-37, its N-terminal truncated form FF-33, and their fluorescent derivatives (which retained structure and activity). The results showed several differences, between LL-37 and other native antimicrobial peptides, that may shed light on its in vivoactivities. Most interestingly, LL-37 exists in equilibrium between monomers and oligomers ...
https://portlandpress.com/biochemj/article-abstract/341/3/501/36526/Structure-and-organization-of-the-human
Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37 -...Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37 -...
Fingerprint Dive into the research topics of Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37. Together they form a unique fingerprint. ...
https://scholars.uthscsa.edu/en/publications/chlamydial-plasmid-encoded-virulence-factor-pgp3-neutralizes-the-/fingerprints/?sortBy=alphabetically
Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory...Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory...
Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demonstrate that cyclic stretch of the human bronchial epithelial cell lines VA10 and BCi NS 1.1 leads to down-regulation of cathelicidin antimicrobial peptide (CAMP) gene expression. We show that treatment of VA10 cells with vitamin D3 and/or 4-phenyl butyric acid counteracted cyclic stretch mediated down-regulation of CAMP mRNA and protein expression (LL-37). Further, we observed an increase in pro-inflammatory responses in the VA10 cell line subjected to cyclic stretch. The mRNA expression of the genes encoding pro-inflammatory cytokines IL-8 and IL-1β was increased after cyclic stretching, where as a decrease in gene expression of chemokines IP-10 and RANTES was observed. Cyclic stretch enhanced oxidative
https://peerj.com/articles/1483/
Biomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ELISA | Fisher ScientificBiomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ELISA | Fisher Scientific
Shop a large selection of products and learn more about Biomatik CorporationHuman Cathelicidin Antimicrobial Peptide (CAMP) ELISA Kit, 96 tests.
https://www.fishersci.com/shop/products/elisa-kit-96t-per-kt-4537/501501208
The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study<...
TY - JOUR. T1 - The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study. AU - van Santen, Susanne. AU - Kroot, Joyce J. C.. AU - Zijderveld, Gerard. AU - Wiegerinck, Erwin T.. AU - Spaanderman, Marc E. A.. AU - Swinkels, Dorine W.. PY - 2013/7. Y1 - 2013/7. KW - hepcidin. KW - iron homeostasis. KW - physiology. KW - pregnancy. U2 - 10.1515/cclm-2012-0576. DO - 10.1515/cclm-2012-0576. M3 - Article. C2 - 23241678. VL - 51. SP - 1395. EP - 1401. JO - Clinical Chemistry and Laboratory Medicine. JF - Clinical Chemistry and Laboratory Medicine. SN - 1434-6621. IS - 7. ER - ...
https://cris.maastrichtuniversity.nl/en/publications/the-iron-regulatory-hormone-hepcidin-is-decreased-in-pregnancy-a-
The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunityThe role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity
Antimicrobial peptides are multifunctional in innate immunity and wound repair of multicellular organisms. We were the first to discover that histatins, a family of salivary antimicrobial peptides, enhance epithelial cell migration, suggesting a role in oral wound healing. It is unknown whether histatins display innate-immunity activities, similar to other antimicrobial peptides such as LL-37. Therefore, we compared the effect of Histatin-2 and LL-37 on several activities within the context of wound healing and innate immunity. We found that Histatin-2 enhances fibroblast migration, but only weakly induces proliferation. LL-37 enhances both fibroblast migration and proliferation, but only at a narrow concentration optimum (approximately 1 μm). At higher concentrations LL-37 causes cell death, whereas Histatin-2 is not cytotoxic. Both peptides do not alter fibroblast-to-myofibroblast differentiation. Histatin-2 does not alter interleukin-8 (IL-8) expression and lipopolysaccharide (LPS)-elevated ...
http://dare.uva.nl/search?metis.record.id=325697
Antimicrobial peptide LL-37 on surfaces presenting carboxylate anions<...
TY - JOUR. T1 - Antimicrobial peptide LL-37 on surfaces presenting carboxylate anions. AU - Qin, G. T.. AU - Lopez, A.. AU - Santos, C.. AU - McDermott, Alison. AU - Cai, C. Z.. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Antimicrobial peptides (AMPs) are part of the immune system in a wide range of organisms. They generally carry positive charges under physiological conditions, allowing them to accumulate on the negatively charged bacterial membrane as the first step of bactericidal action. The concentration range of AMPs necessary for rapid killing of bacteria tested in vitro is much higher than levels found at epithelial surfaces and body fluids in vivo, and close to the a level that is toxic to the host cells. It is likely that AMPs in vivo are localized and act cooperatively to enhance antimicrobial activity, while the global concentration is low thus demonstrating low toxicity to host cells. Herein we employed well-defined mixed self-assembled monolayers (SAMs) to localize LL-37, one of the most ...
https://researchportal.northumbria.ac.uk/en/publications/antimicrobial-peptide-ll-37-on-surfaces-presenting-carboxylate-an
PTH/PTHrP and Vitamin D Control Antimicrobial Peptide Expression and Susceptibility to Bacterial Skin Infection | Science...PTH/PTHrP and Vitamin D Control Antimicrobial Peptide Expression and Susceptibility to Bacterial Skin Infection | Science...
The production of antimicrobial peptides is essential for protection against a wide variety of microbial pathogens and plays an important role in the pathogenesis of several diseases. The mechanisms responsible for expression of antimicrobial peptides are incompletely understood, but a role for vitamin D as a transcriptional inducer of the antimicrobial peptide cathelicidin has been proposed. We show that 1,25-dihydroxyvitamin D3 (1,25-D3) acts together with parathyroid hormone (PTH), or the shared amino-terminal domain of PTH-related peptide (PTHrP), to synergistically increase cathelicidin and immune defense. Administration of PTH to mouse skin decreased susceptibility to skin infection by group A Streptococcus. Mice on dietary vitamin D3 restriction that responded with an elevation in PTH have an increased risk of infection if they lack 1,25-D3. These results identify PTH/PTHrP as a variable that serves to compensate for inadequate vitamin D during activation of antimicrobial peptide ...
http://stm.sciencemag.org/content/4/135/135ra66
Antimicrobial peptides derived from growth factorsAntimicrobial peptides derived from growth factors
Growth factors, comprising diverse protein and peptide families, are involved in a multitude of developmental processes, including embryogenesis, angiogenesis, and wound healing. Here we show that peptides derived from HB-EGF, amphiregulin, hepatocyte growth factor, PDGF-A and PDGF-B, as well as various FGFs are antimicrobial, demonstrating a previously unknown activity of growth factor-derived peptides. The peptides killed the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, and the Gram-positive Bacillus subtilis, as well as the fungus Candida albicans. Several peptides were also active against the Gram-positive S. aureus. Electron microscopy analysis of peptide-treated bacteria, paired with analysis of peptide effects on liposomes, showed that the peptides exerted membrane-breaking effects similar to those seen after treatment with the classical human antimicrobial peptide LL-37. Furthermore, HB-EGF was antibacterial per se, and its epitope GKRKKKGKGLGKKRDPCLRKYK retained ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:39168
tuberculosis1tuberculosis1
Gombart AF , Borregaard N , Koeffler HP . Department of Medicine, Division of Hematology/Oncology, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA. [email protected] The innate immune system of mammals provides a rapid response to repel assaults from numerous infectious agents including bacteria, viruses, fungi, and parasites. A major component of this system is a diverse combination of cationic antimicrobial peptides that include the alpha- and beta-defensins and cathelicidins. In this study, we show that 1,25-dihydroxyvitamin D3 and three of its analogs induced expression of the human cathelicidin antimicrobial peptide (CAMP) gene. This induction was observed in acute myeloid leukemia (AML), immortalized keratinocyte, and colon cancer cell lines, as well as normal human bone marrow (BM) -derived macrophages and fresh BM cells from two normal individuals and one AML patient. The induction occurred via a consensus vitamin D response ...
http://www.denvernaturopathic.com/news/tuberculosis1.html
Rapid sequence divergence in mammalian beta-defensins by adaptive evolution<...
TY - JOUR. T1 - Rapid sequence divergence in mammalian beta-defensins by adaptive evolution. AU - Maxwell, A I. AU - Morrison, G M. AU - Dorin, J R. PY - 2003. Y1 - 2003. N2 - beta-Defensin genes encode broad spectrum antimicrobial cationic peptides. We have analysed the largest murine and human clusters of these genes, which localise to mouse and human chromosome 8. Using hidden Markov models, we identified novel mouse and human beta-defensin genes. We subsequently found full-length expressed transcripts for these novel genes. Expression in the mouse was high in brain and reproductive tissues. Fourteen murine beta-defensins could be grouped into two clear sub-groups by virtue of their position and high signal sequence (exon 1 encoded) identity. In contrast, there was a very low level of sequence conservation in the exon 2 region encoding the mature antimicrobial peptide. Evolutionary analysis revealed strong evidence that following gene duplication, exon 1 and surrounding non-coding DNA show ...
https://www.research.ed.ac.uk/en/publications/rapid-sequence-divergence-in-mammalian-beta-defensins-by-adaptive
LL17-32LL17-32
Peptides , Antimicrobial and Related Peptides , LL17-32; This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.; FKRIVQRIKDFLRNLV; H-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-OH
https://anaspec.com/products/product.asp?id=57717&productid=34238
Distinct antimicrobial peptide expression determines host species-specific bacterial associations - Franzenburg SörenDistinct antimicrobial peptide expression determines host species-specific bacterial associations - Franzenburg Sören
en] Animals are colonized by coevolved bacterial communities, which contribute to the hosts health. This commensal microbiota is often highly specific to its host-species, inferring strong selective pressures on the associated microbes. Several factors, including diet, mucus composition, and the immune system have been proposed as putative determinants of host-associated bacterial communities. Here we report that species-specific antimicrobial peptides account for different bacterial communities associated with closely related species of the cnidarian Hydra. Gene family extensions for potent antimicrobial peptides, the arminins, were detected in four Hydra species, with each species possessing a unique composition and expression profile of arminins. For functional analysis, we inoculated arminin-deficient and control polyps with bacterial consortia characteristic for different Hydra species and compared their selective preferences by 454 pyrosequencing of the bacterial microbiota. In contrast ...
http://orbilu.uni.lu/handle/10993/8184
Human CAMP ELISA Kit Human CAMP ELISA Kit : Plasmid,ELISA Kits,antibodies,strains, - Nova lifetech IncHuman CAMP ELISA Kit Human CAMP ELISA Kit : Plasmid,ELISA Kits,antibodies,strains, - Nova lifetech Inc
Human CAMP ELISA Kit allows for the in vitro quantitative determination of Human Cathelicidin antimicrobial peptide concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
https://www.lifescience-market.com/human-elisa-kit-c-65_70/human-camp-elisa-kit-p-2210.html
Novel Gemini vitamin D3 analogs - Danish National Research Database-Den Danske ForskningsdatabaseNovel Gemini vitamin D3 analogs - Danish National Research Database-Den Danske Forskningsdatabase
We have synthesized 39 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] analogs having two side chains attached to carbon-20 (Gemini) with various modifications and compared their anticancer activities. Five structure-function rules emerged to identify analogs with enhanced anticancer activity. One of these active analogs, BXL-01-0126, was more potent than 1,25(OH)2D3 in mediating 50% clonal inhibition of cancer cell growth. Murine studies found that BXL-01-0126 and 1,25(OH)2D3 had nearly the same potency to raise serum calcium levels. Taken together, BXL-01-0126 when compared to 1,25(OH)2D3 has greater anticancer potency, but similar toxicity causing hypercalcemia. We focused on the effect of these compounds on the stimulation of expression of human cathelicidin antimicrobial peptide (CAMP) whose gene has a vitamin D response element in its promoter. Expression of CAMP mRNA and protein increased in a dose-response fashion after exposure of acute myeloid leukemia (AML) cells to the Gemini analog, ...
http://www.forskningsdatabasen.dk/catalog/246908706
The Gift For Life Felines - GENOSTIMThe Gift For Life Felines - GENOSTIM
The Gift for Life® Exclusive all natural Feline product is designed for cellular rejuvenation, vitality and longevity. TGFL offers numerous supportive properties for all dog breeds that have been spayed or neutered or are over the age of 7. It is formulated to address the Endocrine issues that cause our pets disease, joint pain and decreased energy and activity. This formula activates the adrenal cortex to start producing 24 life giving hormones lost from elective surgeries or aging. Through our inclusion of naturally occurring Cationic Host Defense Peptides (CHDPs), your pets Viral Shield will be supported by broad-spectrum anti-bacterial, anti-viral, and anti-fungal immunomodulatory activity.. The Gift for Life® has been called the fountain of Youth for pets! This is a fast acting and very effective product. Many owners will see a difference within days. TGFL is a chewable treat and is given twice a day. One in the morning and one in the evening.. The Gift for Life® Feline ingredients ...
https://genostim.com/product/the-gift-for-life-felines/
Polynucleotide phosphorylase negatively regulates DNA-mediated aggregation and serum resistance in Neisseria meningitidisPolynucleotide phosphorylase negatively regulates DNA-mediated aggregation and serum resistance in Neisseria meningitidis
The Gram-negative bacterium Neisseria meningitidis is a transient commensal of the human nasopharynx, but occasionally causes life-threatening disease. During colonisation of its niche, N. meningitidis has to overcome innate immune defences, including the expression of antimicrobial peptides (AMPs). Meningococcal resistance to the host defence peptide LL-37 was investigated in Papers I and II. The polysaccharide capsule and lipopolysaccharide (LPS) were found to increase LL-37 resistance by inhibiting peptide binding to the bacteria. Further, N. meningitidis responded to sub-lethal doses of LL-37 by an increase in capsule biosynthesis. Intriguingly, adhesion to epithelial cells and tissues protected N. meningitidis from physiological concentrations of LL-37 and two other helical peptides. The protective effect was mediated by RhoA- and Cdc42-dependent host cell signalling and cholesterol-rich membrane microdomains. The host epithelium thus seems to play an active role in AMP ...
http://su.diva-portal.org/smash/record.jsf?pid=diva2:686461
Lipopolysaccharide binding protein - WikipediaLipopolysaccharide binding protein - Wikipedia
Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene.[5][6] LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.[7] The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma ...
https://en.wikipedia.org/wiki/Lipopolysaccharide-binding_protein
The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes...The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes...
The ability of epithelial cells to sense the external environment and communicate this information to the local immune system, thereby initiating appropriate responses, is essential for the maintenance of health and prevention of the development of chronic inflammatory diseases. Our studies have shown that an oral probiotic commensal strain of S. salivarius is able to inhibit inflammatory responses in human bronchial epithelial cells by downregulating the NF-κB pathway. This is consistent with an emerging paradigm that indicates the downregulation of epithelial immune responses by commensal bacteria (8, 13, 24, 38, 48). Not only did S. salivarius K12 inhibit baseline synthesis of IL-8, but it also suppressed IL-8 secretion when cells were stimulated with pathogenic P. aeruginosa, Salmonella serovar Typhimurium flagellin, or the immunomodulatory host defense peptide LL-37. Most previous studies have focused on IL-8 and IL-6 responses, but here it was demonstrated that this commensal bacterium ...
https://iai.asm.org/content/76/9/4163
KAKEN - Research Projects | Study on the interaction between periodontal bacteria and human antimicrobial peptides (KAKENHI...KAKEN - Research Projects | Study on the interaction between periodontal bacteria and human antimicrobial peptides (KAKENHI...
Principal Investigator：KOMATSUZAWA Hitoshi, Project Period (FY)：2007 - 2008, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Morphological basic dentistry
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19592114/
Manipulation of the hepcidin pathway for therapeutic purposes | HaematologicaManipulation of the hepcidin pathway for therapeutic purposes | Haematologica
Targeting the BMP pathway: as the BMP pathway plays a key role in stimulating hepcidin transcription, sequestration of BMP ligands could decrease hepcidin expression. Heparin, a glycosaminoglycan widely used as an anticoagulant, has long been known to bind BMPs.68 Poli and colleagues demonstrated that heparin inhibited hepcidin expression in hepatic cell lines as well as in mice.69 Daily injections in mice for seven days (50 mg/kg/d) decreased hepcidin mRNA expression and SMAD phosphorylation, increased serum iron and reduced spleen iron concentration. In 5 patients treated with low molecular weight heparin to prevent deep vein thrombosis, serum hepcidin concentration decreased by 80-85% within 2-5 days after the start of the treatment. Concurrently, increased serum iron levels and transferrin saturation were noted in all 5 patients. Although the safety profile of heparin is well understood, its anticoagulant activity hinders its wider application to iron-restricted disorders. To address this, ...
http://www.haematologica.org/content/98/11/1667?ijkey=6d67d8b0f1eb807a4905b52dd669f25db52b7ed2&keytype2=tf_ipsecsha
Anti-Biofilm PeptidesAnti-Biofilm Peptides
This resistance is adaptive in that it depends on the biofilm growth state and although many explanations have been provided to explain it, it is likely that changes in gene and/or protein expression in the biofilm state explain why organisms become resistant.. Intriguingly despite this problem, not a single antibiotic has been developed for treating biofilms. We have started to address this using as templates the cationic host defence (antimicrobial) peptides, which are produced by virtually all organisms as a major part of their innate defences against infection. They are a key component of innate immunity and have multiple mechanisms that enable them to deal with infections and inflammation, including selective modulation of innate immunity, activity against bacterial biofilms (the cause of 65% of all human infections) and direct antimicrobial activity. We made the breakthrough observation that human peptide LL-37 was able to inhibit Pseudomonas aeruginosa biofilms at one sixteenth of its MIC ...
http://cmdr.ubc.ca/bobh/research-project/anti-biofilm-peptides/
The Role of Antimicrobial Peptides at the Ocular Surface<...
TY - JOUR. T1 - The Role of Antimicrobial Peptides at the Ocular Surface. AU - McDermott, Alison. PY - 2009/1. Y1 - 2009/1. N2 - Antimicrobial peptides (AMPs) such as defensins and cathelicidins are small peptides with broad-spectrum activity against bacteria, fungi and viruses. In addition, several AMPs modulate mammalian cell behaviours including migration, proliferation and cytokine production. This review describes findings from recent studies showing the presence of various AMPs at the human ocular surface and discusses their mechanism of antimicrobial action and potential non-microbicidal roles. Corneal and conjunctival epithelial cells produce β-defensins and the cathelicidin LL-37, whereas neutrophils, infiltrating in response to a specific stimulus, supply additional LL-37 as well as α-defensins. In vitro studies suggest that LL-37 and human β-defensin-3 are the most likely to have significant independent antimicrobial activity, while other AMPs may act synergistically to help ...
https://researchportal.northumbria.ac.uk/en/publications/the-role-of-antimicrobial-peptides-at-the-ocular-surface
Crystal structure and functional mechanism of a human antimicrobial membrane channel | PNASCrystal structure and functional mechanism of a human antimicrobial membrane channel | PNAS
Multicellular organisms fight bacterial and fungal infections by producing peptide-derived broad-spectrum antibiotics. These host-defense peptides compromise the integrity of microbial cell membranes and thus evade pathways by which bacteria develop rapid antibiotic resistance. Although more than 1,700 host-defense peptides have been identified, the structural and mechanistic basis of their action remains speculative. This impedes the desired rational development of these agents into next-generation antibiotics. We present the X-ray crystal structure as well as solid-state NMR spectroscopy, electrophysiology, and MD simulations of human dermcidin in membranes that reveal the antibiotic mechanism of this major human antimicrobial, found to suppress Staphylococcus aureus growth on the epidermal surface. Dermcidin forms an architecture of high-conductance transmembrane channels, composed of zinc-connected trimers of antiparallel helix pairs. Molecular dynamics simulations elucidate the unusual ...
https://www.pnas.org/content/early/2013/02/19/1214739110.abstract?sid=cf439b4c-00b6-40f1-99c3-985bf7d9fd98
June, 2016 | Caspase1-Inhibitors caspase1inhibitor.com
Moreover the human α-Defensin human neutrophil peptide 1 was revealed to show anti-HIV activity. HNP-one inhibits the binding of the virus to its coreceptor , the endocytosis of the virus into the target cell as well as the release of the HIV-genome from the endosome into the cytoplasm. Even so HNP-one did not inhibit the endocytosis of Influenza A virus displaying some selectivity of the AMPs in their tropism. These final results evidently demonstrate that defensins not only screen antimicrobial activity but in addition are lively from viruses as nicely.Bactericidal/permeability-increasing protein belongs to the class of AMPs. In distinction to the over mentioned defensins BPI owing to the 55 kDa molecular measurement of the protein is structurally significantly a lot more intricate than the peptides, which are in the selection of 3-five kDa. The BPI protein loved ones contains of far more than ten associates but only BPI alone displays a powerful antimicrobial exercise. BPI functions ...
http://www.caspase1inhibitor.com/2016/06/
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including...Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including...
Using our CAMP discovery process and only 100 μl of alligator plasma, we have previously identified five novel antimicrobial peptides from A. mississippiensis that exhibit antibacterial activity [8]. Our bioprospecting-based process provides a unique access to the antimicrobial peptidome, and is a significant advance in the effort to identify novel antimicrobial peptides in nature. In this study, we present detailed characterization of the structure and function of three alligator plasma-derived peptides: Apo5, Apo6, and A1P. We demonstrated that Apo5, Apo6, and A1P are potent antimicrobial peptides that extend their efficacy against multi-drug resistant and clinically relevant pathogens, such as A. baumannii. The two peptides Apo5 and Apo6 are both derived from a predicted apolipoprotein C-1 in A. mississippiensis. Apolipoproteins bind lipids; apolipoprotein C-1 in particular is known to bind phospholipids and is a marker of apoptosis [11, 12, 43, 44]. Apo6 is a smaller derivative of Apo5; ...
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-016-0799-z
Design, synthesis and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. - ARC Centre for...Design, synthesis and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. - ARC Centre for...
Cumulatively, CIPPS researchers have published over 1800 publications, books and book chapters in the past 10 years. 310,000 Citations. CIPPS researchers have been cited over 310,000 times. ...
https://cipps.org.au/archives/journal_article/design-synthesis-and-characterization-of-cyclic-analogues-of-the-iron-regulatory-peptide-hormone-hepcidin
Azurophilic granule - WikipediaAzurophilic granule - Wikipedia
An azurophilic granule is a cellular object readily stainable with a Romanowsky stain. In white blood cells and hyperchromatin, staining imparts a burgundy or merlot coloration. Neutrophils in particular are known for containing azurophils loaded with a wide variety of anti-microbial defensins that fuse with phagocytic vacuoles. Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, bactericidal/permeability-increasing protein, lysozyme, cathepsin G, proteinase 3, and proteoglycans. Azurophil granules are also known as primary granules. Furthermore, the term azurophils may refer to a unique type of cells, identified only in reptiles. These cells are similar in size to so-called heterophils with abundant cytoplasm that is finely to coarsely granular and may sometimes contain vacuoles. Granules may impart a purplish hue to the cytoplasm, particularly to the outer region. Occasionally, azurophils are observed with vacuolated ...
https://en.wikipedia.org/wiki/Azurophilic_granule
The antimicrobial peptide Tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents...
TY - JOUR. T1 - The antimicrobial peptide Tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents ureteral stent Pseudomonas infection in a rat subcutaneous pouch model. AU - Minardi, Daniele. AU - Ghiselli, Roberto. AU - Cirioni, Oscar. AU - Giacometti, Andrea. AU - Kamysz, Wojciech. AU - Orlando, Fiorenza. AU - Silvestri, Carmela. AU - Parri, Gianni. AU - Kamysz, Elzbieta. AU - Scalise, Giorgio. AU - Saba, Vittorio. AU - Giovanni, Muzzonigro. PY - 2007/12. Y1 - 2007/12. N2 - We investigated the efficacy of Tachyplesin III alone or combined with piperacillin-tazobactam (TZP) to prevent biofilm formation in vitro and in a rat model of Pseudomonas aeruginosa ureteral stent infection. We have observed that in vitro TZP, in presence of Tachyplesin III, showed minimal inhibitory concentrations (MIC)s twofold and minimal bactericidal concentrations (MBC)s eightfold lower. The in vivo study showed that rats that received intraperitoneal TZP showed the ...
https://moh-it.pure.elsevier.com/en/publications/the-antimicrobial-peptide-tachyplesin-iii-coated-alone-and-in-com
Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue...
TY - JOUR. T1 - Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S. AU - Lee, D. L.. AU - Powers, J. P.S.. AU - Pflegerl, K.. AU - Vasil, M. L.. AU - Hancock, R. E.W.. AU - Hodges, R. S.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2004/2. Y1 - 2004/2. N2 - Gramicidin S (GS) is a 10-residue cyclic β-sheet peptide with lytic activity against the membranes of both microbial and human cells, i.e. it possesses little to no biologic specificity for either cell type. Structure-activity studies of de novo-designed 14-residue cyclic peptides based on GS have previously shown that higher specificity against microbial membranes, i.e. a high therapeutic index (TI), can be achieved by the replacement of a single L-amino acid with its corresponding D-enantiomer [Kondejewski, L.H. et al. (1999) J. Biol. Chem. 274, 13181]. The diastereomer with a D-Lys ...
https://portal.sahmriresearch.org/en/publications/effects-of-single-d-amino-acid-substitutions-on-disruption-of-%CE%B2-s
KoreaMedKoreaMed
The mean relative wall thickness (RWT) and left ventricular mass index (LVMI) were 0.38 and 42.0 g/m2.7, respectively. The mean ejection fraction (EF) and early diastolic mitral inflow to annulus velocity ratio (E/e²) were 64.1% and 9.9, respectively. Although EF and E/e² were not associated with high serum hepcidin, RWT and LVMI were significantly associated with high serum hepcidin levels in univariate logistic regression analysis. In multivariate logistic regression analysis after adjusting for variables related to anemia, bone mineral metabolism, comorbidities, and inflammation, however, only each 0.1-unit increase in RWT was associated with increased odds of high serum hepcidin (odds ratio, 1.989; 95% confidence interval, 1.358-2.916; P < 0.001). In the subgroup analysis, the independent relationship between RWT and high serum hepcidin level was valid only in women and patients with low transferrin saturation (TSAT ...
https://koreamed.org/SearchBasic.php?RID=2466579
Antimicrobial Peptides and Peptaibols, Substitutes for Conventional Antibiotics | Bentham ScienceAntimicrobial Peptides and Peptaibols, Substitutes for Conventional Antibiotics | Bentham Science
Title: Antimicrobial Peptides and Peptaibols, Substitutes for Conventional Antibiotics. VOLUME: 16 ISSUE: 28. Author(s):Herve Duclohier. Affiliation:Institut de Biologie et Physiologie Cellulaires, UMR 6187 CNRS-Universite de Poitiers, 1 rue Geoges Bonnet, BP 633, 86022 Poitiers France.. Keywords:Antimicrobial peptides, peptaibols, alamethicin, planar lipid bilayers. Abstract: In this review, the antimicrobial properties of a number of peptides are described. We first deal with helical linear peptides such as the well-known gramicidin, magainins, melittin, and other less well-known or more recently discovered peptides. Then, betasheet peptides (defensins isolated from insects and also from mammalian tissues) and cyclic peptides like amphotericin B are described before the properties of peptaibols (containing the non-coded amino acid Aib) are discussed. Alamethicin remains the prototype of this class and its biophysical properties (mostly focussing on channel- or pore-formation in planar lipid ...
https://www.eurekaselect.com/72676/article/antimicrobial-peptides-and-peptaibols-substitutes-conventional-antibiotics?tracking-code=4
ALZFORUM | NETWORKING FOR A CUREALZFORUM | NETWORKING FOR A CURE
The study describes an elegant tool for what has been a frustrating problem. Of particular interest to us, this study shows that Aβ dimers have striking structural similarities to the dimeric forms of the antimicrobial peptides human NP2, horseshoe crab tachystatin B, and mouse α-defensin. We recently reported on the antimicrobial activity of Aβ, and our newest data suggest dimerization is a key event in turning relatively inactive Aβ monomers into forms that can attack bacteria. This is not a phenomenon restricted to Aβ. It has been known for some time that oligomerization has an important role in the action and targeting of a number of antimicrobial proteins (AMPs), including the archetypal antimicrobial peptide LL-37 which can form oligomers, fibrils, and birefringent amyloid (albeit, LL-37 amyloid has only been observed in vitro to date). Oligomerization is also a key mechanism for antimicrobial protein-mediated agglutination and inactivation of viral particles.. Despite this central ...
http://www.alzforum.org/papers/crystal-structure-amyloid-v-p3-fragment-provides-model-oligomer-formation-alzheimers-disease
Scientific Protocols - Production of recombinant hBD-1 in Escherichia coli and its specific polyclonal antibody in rabbitsScientific Protocols - Production of recombinant hBD-1 in Escherichia coli and its specific polyclonal antibody in rabbits
Antimicrobial peptides represent the first-line host defence against microbial pathogens and an essential component of innate immunity. They have received growing interest because of their potential use as therapeutic antibiotics. Due to the fact that most antimicrobial peptides are toxic to prokaryotic host cells, they are currently often produced by chemical synthesis. However, this is too costly for them to be used when large quantities of antimicrobial peptides are required for investigations and clinical trials. Thus, the convenience and cost efficiencies of bacterial production of antimicrobial peptides have become a bottleneck problem.. As an important group of antimicrobial peptides human ß-defensins are cationic peptides with 38-47 amino acid residues showing three strands of anti-parallel β-sheets that provide a compact small structure [1,2]. We describe an optimized strategy for recombinant expression of hBD-1 and its mutants in Escherichia coli, to efficiently produce milligram ...
https://protocols.scienceexchange.com/protocols/production-of-recombinant-hbd-1-in-escherichia-coli-and-its-specific-polyclonal-antibody-in-rabbits
Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae) |...Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae) |...
Three novel antimicrobial peptides (AMPs), named panurgines (PNGs), were isolated from the venom of the wild bee Panurgus calcaratus. The dodecapeptide of the sequence LNWGAILKHIIK-NH2 (PNG-1) belongs
https://link.springer.com/article/10.1007%2Fs00726-013-1482-4
weisshaa | UW-Madison Department of Chemistry
We participate in the revolution in fluorescence microscopy of biological systems. It is now possible to measure the spatial distribution of proteins and DNA loci with 30-nm precision in live cells and to track their motion in real time. The result is an unprecedented, high resolution view of biological structure and activity. Areas of current interest include: (1) The motion and spatial distribution of GFP-labeled species in live E. coli cells. Species of interest include RNA polymerase, ribosomes, architectural proteins, and specific DNA loci. The transcription/translation machinery (ribosomes, the nucleoid, and RNAP) all exhibit a remarkable level of spatial organization. (2) The time-resolved attack of antimicrobial agents on single bacterial cell membranes. Examples include LL-37, a human antimicrobial peptide, and synthetic random copolymers designed by the Gellman group. Simultaneous two-color imaging of the antimicrobial and cytoplasmic or periplasmic GFP yields unprecedented insight ...
http://chembio.chem.wisc.edu/users/weisshaa
Changes in serum hepcidin according to thyrometabolic status in patients with Graves disease in: Endocrine Connections Volume...Changes in serum hepcidin according to thyrometabolic status in patients with Graves disease in: Endocrine Connections Volume...
Hepcidin, presumed to be a potential link in the mutual relationship between thyrometabolic and haematologic status, is a liver-derived protein encoded by the HAMP gene, responsible mainly for bodily Fe distribution (9). The mechanism of hepcidin response to inflammatory stimuli comprises two possible pathways: one through bone morphogenetic protein-mothers against decapentaplegic (BMP-SMAD) and more specifically via Janus kinase (JAK) signal transducer and activator of transcription 3 (STAT3). The latter axis is triggered by cytokines, mainly IL-6, which activates JAK2 and leads to phosphorylation of STAT3, enabling its translocation to the nucleus and upregulation of HAMP gene transcription. IL-6 also contributes to hepcidin regulation via the BMD pathway (14). Cross-talk between two presented pathways has been postulated (15). Stimulated hepcidin affects ferroportin, which is a cellular iron transporter, causing its internalization and degradation, thus retaining Fe absorption from a lumen of ...
https://ec.bioscientifica.com/view/journals/ec/9/3/EC-20-0017.xml?rskey=tVvERt&result=63
Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral,...Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral,...
TY - JOUR. T1 - Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents. AU - Conlon, JM. AU - Mechkarska, M. AU - Lukic, ML. AU - Flatt, Peter. PY - 2014/5/2. Y1 - 2014/5/2. N2 - Frog skin constitutes a rich source of peptides with a wide range of biological properties. These include host-defense peptides with cytotoxic activities against bacteria, fungi, protozoa, viruses, and mammalian cells. Several hundred such peptides from diverse species have been described. Although attention has been focused mainly on antimicrobial activity, the therapeutic potential of frog skin peptides as anti-infective agents remains to be realized and no compound based upon their structures has yet been adopted in clinical practice. Consequently, alternative applications are being explored. Certain naturally occurring frog skin peptides, and analogs with improved therapeutic properties, show selective ...
https://ulster-staging.pure.elsevier.com/en/publications/potential-therapeutic-applications-of-multifunctional-host-defens-3
Suppression of Iron-Regulatory Hepcidin by Vitamin D | American Society of NephrologySuppression of Iron-Regulatory Hepcidin by Vitamin D | American Society of Nephrology
Data for ferroportin and ferritin expression in vitamin D-treated monocytes and hepatocytes are consistent with the actions of hepcidin in promoting post-transcriptional suppression of ferroportin protein.19 On the basis of data presented in this study, we speculate that 25D and 1,25D can act to oppose this response and maintain membrane expression of ferroportin (Figure 5). Hepcidin-mediated loss of membrane ferroportin is known to be associated with intracellular retention of iron, leading in turn to iron-restrictive anemia.5 This has immediate implications for the control of systemic iron homeostasis but will also influence host defense during acute infections. Iron is essential for the survival and growth of almost all organisms, and an important strategy for mammalian antimicrobial defense is based on depriving pathogens of this essential nutrient.20 Thus, another facet of hepcidin physiology is its contribution to host innate immune function.3,21 By targeting ferroportin and decreasing ...
https://jasn.asnjournals.org/node/7678.full.print
OpenEmory | Search ResultsOpenEmory | Search Results
Objectives High-dose vitamin D3increases plasma total 25-hydroxyvitamin D [25(OH)D] in critically ill, ventilated patients; however, to our knowledge, the effect on plasma levels of free (nonprotein-bound) 25(OH)D has not been investigated in critical illness. Moreover, the relationship of free 25(OH)D and the regulation of endogenous antimicrobial peptides (AMPs) remains unknown. The aims of this study were to determine in critically ill adults with respiratory failure the effect of previous high-dose regimens of vitamin D3on free 25(OH)D concentrations, the relationship of free 25(OH)D with circulating cathelicidin (LL-37) and human beta-defensin-2 (hBD-2), and the associations between plasma levels of free 25(OH)D and these AMPs to alveolar macrophage phagocytosis function. Methods In a double blind, randomized controlled trial, critically ill ventilator-dependent adults (N = 30) received enteral vitamin D3(250,000 or 500,000 IU total over 5 d) or placebo. Plasma was obtained serially for ...
https://open.library.emory.edu/publications/search/?keywords=controlledtri
Esculentin-2-MG1 antimicrobial peptide precursor - Creative PeptidesEsculentin-2-MG1 antimicrobial peptide precursor - Creative Peptides
Creative Peptides offers Esculentin-2-MG1 antimicrobial peptide precursor for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
https://www.creative-peptides.com/product/esculentin-mg1-antimicrobial-peptide-precursor-item-af1556-30622.html
Antimicrobial peptides extend lifespan in Drosophila<...
TY - JOUR. T1 - Antimicrobial peptides extend lifespan in Drosophila. AU - Loch, Gerrit. AU - Zinke, Ingo. AU - Mori, Tetsushi. AU - Carrera, Pilar. AU - Schroer, Jonas. AU - Takeyama, Haruko. AU - Hoch, Michael. N1 - Publisher Copyright: © 2017 Loch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2017/5. Y1 - 2017/5. N2 - Antimicrobial peptides (AMPs) are important defense molecules of the innate immune system. High levels of AMPs are induced in response to infections to fight pathogens, whereas moderate levels induced by metabolic stress are thought to shape commensal microbial communities at barrier tissues. We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly ...
https://waseda.pure.elsevier.com/en/publications/antimicrobial-peptides-extend-lifespan-in-drosophila
Babitt, J.L. and Lin, H.Y. (2010) Molecular Mechanisms of Hepcidin Regulation Implications for the Anemia of CKD. American...Babitt, J.L. and Lin, H.Y. (2010) Molecular Mechanisms of Hepcidin Regulation Implications for the Anemia of CKD. American...
Babitt, J.L. and Lin, H.Y. (2010) Molecular Mechanisms of Hepcidin Regulation Implications for the Anemia of CKD. American Journal of Kidney Diseases, 55, 726-741.
https://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=1551502
Ontogeny and modulation after PAMPs stimulation of β-defensin, hepcidin, and piscidin antimicrobial peptides in meagre (|i...Ontogeny and modulation after PAMPs stimulation of β-defensin, hepcidin, and piscidin antimicrobial peptides in meagre (|i...
Fingerprint Dive into the research topics of Ontogeny and modulation after PAMPs stimulation of β-defensin, hepcidin, and piscidin antimicrobial peptides in meagre (,i,Argyrosomus regius,/i,) . Together they form a unique fingerprint. ...
https://abdn.pure.elsevier.com/en/publications/ontogeny-and-modulation-after-pamps-stimulation-of-%CE%B2-defensin-hep/fingerprints/
Impact of Host Defense Peptides on Chronic Wounds and Infections | SpringerLinkImpact of Host Defense Peptides on Chronic Wounds and Infections | SpringerLink
Chronic wounds are a growing clinical concern worldwide with only a few treatment options available to address the fundamental causes of non-healing wounds. There is increasing evidence that the...
https://link.springer.com/chapter/10.1007%2F15695_2017_88
Vitamin D Reduces Symptoms in Subjects Frequent Respiratory InfectionsVitamin D Reduces Symptoms in Subjects Frequent Respiratory Infections
The subjects received 4,000 IU vitamin D3 or placebo daily for one year. The investigators evaluated the subjects for respiratory tract infection symptoms, malaise, antibiotic consumption, serum 25-hydroxyvitamin D3 levels, microbiological findings and levels of antimicrobial peptides LL-37 and HNP1-3 in nasal fluid. The scientists used this data to calculate an overall infectious score ...
http://www.tobewell.net/wellness-blog/vitamin-d-reduces-symptoms-in-subjects-frequent-respiratory-infections
Liver-expressed antimicrobial peptideLiver-expressed antimicrobial peptide
LEAP2 is a cysteine-rich, and cationic protein. LEAP2 contains a core structure with two disulphide bonds formed by cysteine ... Liver-expressed antimicrobial peptides are a family of mammalian liver-expressed antimicrobial peptides (LEAP). The exact ... In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial ... a novel blood peptide expressed in the liver". Protein Sci. 12 (1): 143-52. doi:10.1110/ps.0213603. PMC 2312392. PMID 12493837 ...
https://en.wikipedia.org/wiki/Liver-expressed_antimicrobial_peptide
Antimicrobial peptidesAntimicrobial peptides
There are some factors that are closely related to the selectivity property of antimicrobial peptides, among which the cationic ... including antimicrobial peptides, in a protein sequence PeptideRanker Bioactive peptide, including antimicrobial peptide, ... Currently, the most widely used antimicrobial peptide is nisin; being the only FDA approved antimicrobial peptide, it is ... In the competition of bacterial cells and host cells with the antimicrobial peptides, antimicrobial peptides will ...
https://en.wikipedia.org/wiki/Antimicrobial_peptides
Cell-penetrating peptideCell-penetrating peptide
Helical β-peptides mimic antimicrobial activities of host defense peptides. This feature requires the orientation of cationic - ... "Inhibition of herpes simplex virus type 1 infection by cationic beta-peptides". Antimicrobial Agents and Chemotherapy. 52 (6): ... "A Noncovalent Peptide-Based Strategy for Peptide and Short Interfering RNA Delivery". Handbook of Cell-Penetrating Peptides, ... In the absence of linker, the cationic peptide can interact more efficient with the target cell and cellular uptake occurs ...
https://en.wikipedia.org/wiki/Cell-penetrating_peptide
MP196MP196
... is a synthetic antimicrobial peptide. It falls under the structural class: short cationic peptides. Since it is a short ... April 2014). "Small cationic antimicrobial peptides delocalize peripheral membrane proteins". Proceedings of the National ... MP196 can be used as the key structure in order to develop any potential antimicrobial peptides which could help in fighting ... as this cationic peptide prefers incorporating into membranes which have a higher negatively charged phospholipid ratio. ...
https://en.wikipedia.org/wiki/MP196
Fixation (histology)Fixation (histology)
"Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria". Antimicrobial Agents and ...
https://en.wikipedia.org/wiki/Fixation_(histology)
Robert E. W. HancockRobert E. W. Hancock
This then led to investigating small cationic peptides from nature, originally termed cationic antimicrobial peptides, but ... Currently Hancock and his lab's research interests include small cationic peptides as novel antimicrobials, broad-spectrum anti ... Hancock, R.E.W. (2001). "Cationic peptides: effectors in innate immunity and novel antimicrobials". The Lancet Infectious ... Hancock REW, Haney EF, Gill EE (2016). "The immunology of host defence peptides: Beyond antimicrobial activity". Nat Rev ...
https://en.wikipedia.org/wiki/Robert_E._W._Hancock
Suzana StrausSuzana Straus
... comparison with cationic antimicrobial peptides and lipopeptides". Biochimica et Biophysica Acta. 1758 (9): 1215-1223. doi: ... Raheem, Nigare; Straus, Suzana K. (2019). "Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm ... Straus has smultaneously looked to establish structure-function relationships in antimicrobial peptides. Suzana Straus; Robert ... Prashant Kumar; Jayachandran N Kizhakkedathu; Suzana K Straus (19 January 2018). "Antimicrobial Peptides: Diversity, Mechanism ...
https://en.wikipedia.org/wiki/Suzana_Straus
OxyopininOxyopinin
It is also 29% identical to the amino acid residues of the frog antimicrobial peptide dermaseptin. Oxyopinins 2a, 2b, 2c, and ... They are the largest linear cationic amphipathic peptides detected in the venom of any spider. They are structurally α-helical ... The sixth peptide oxyopinin 4a (Oxt-4a) was reported in 2011 from Oxyopes takobius. It is composed of 77 amino acid residues, ... The first five peptides, namely oxyopinins 1, 2a, 2b, 2c, and 2d, were described in 2002 from Oxyopes kitabensis. Oxyopinin 1 ...
https://en.wikipedia.org/wiki/Oxyopinin
MagaininMagainin
The magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). The peptides are ... cationic, generally lack a stable conformation in water but form amphipathic α-helix in membranes; their mechanism against ... Protein pages needing a picture, Antimicrobial peptides). ... "Host-defense peptides in skin secretions of African clawed ...
https://en.wikipedia.org/wiki/Magainin
LactoferricinLactoferricin
... is an amphipathic, cationic peptide with anti-microbial and anti-cancer properties. It can be generated by the ... June 2016). "Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine". ... Gifford JL, Hunter HN, Vogel HJ (November 2005). "Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, ... and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural ...
https://en.wikipedia.org/wiki/Lactoferricin
GsMTx-4GsMTx-4
... also serves as a cationic antimicrobial peptide against Gram-positive bacteria. GsMTx-4 was isolated from the venom of ... Compared with other ICK peptides, GsMTx-4 has a relatively high content of lysine residues, which causes the peptide to be more ... This amphiphilic peptide, which consists of 35 amino acids, belongs to the inhibitory cysteine knot (ICK) peptide family. It ... Unlike other ICK peptides, the action of GsMTx-4 is not stereospecific, as both L- and D-GsMTx-4 can block MSCs. Published KD ...
https://en.wikipedia.org/wiki/GsMTx-4
DefensinDefensin
Cationic Antimicrobial Proteins', 'Neutrophil peptides', 'Gamma thionins' amongst others. Proteins called 'defensins' are not ... From this point of view, defensins (as well as antimicrobial peptides in general) are of great interest. It was shown that ... In this sense, the intestinal production of antimicrobial peptides as hBD2 and hBD4 by trefoil from milk might play an ... Wang YP, Lai R (February 2010). "[Insect antimicrobial peptides: structures, properties and gene regulation]". Dong Wu Xue Yan ...
https://en.wikipedia.org/wiki/Defensin
Surgical meshSurgical mesh
"Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide". Materials. 12 ( ... As a drug delivery system, a hernia mesh can be used to deliver antibiotics, antiseptics, antimicrobials, antimicrobial ... FDA Approved Antimicrobial Hernia Meshes MycroMesh and DualMesh Plus by GORE XenMatrix Surgical Graft by BD Ventrio Hernia ... Are antimicrobial biomaterials the longed-for solution?". Biomaterials. 167: 15-31. doi:10.1016/j.biomaterials.2018.03.017. hdl ...
https://en.wikipedia.org/wiki/Surgical_mesh
DermaseptinDermaseptin
Mor A (2000). "Peptide-based antibiotics: a potential answer to raging antimicrobial resistance". Drug Development Research. 50 ... Hancock RE, Falla T, Brown M (1995). "Cationic bactericidal peptides". Advances in Microbial Physiology. 37: 135-75. PMID ... After transient loading of the cells with the non-toxic dermaseptin S4 analogue K4-S4(1-13)a, the peptide is transported in the ... Antimicrobial resistance Amiche M, Seon AA, Pierre TN, Nicolas P (August 1999). "The dermaseptin precursors: a protein family ...
https://en.wikipedia.org/wiki/Dermaseptin
PhagocytosisPhagocytosis
Other antimicrobial peptides are present in these granules, including lactoferrin, which sequesters iron to provide ... Oxygen-independent degradation depends on the release of granules, containing enzymes such as lysozymes, and cationic proteins ...
https://en.wikipedia.org/wiki/Phagocytosis
MurepavadinMurepavadin
It is a synthetic cyclic beta hairpin peptidomimetic based on the cationic antimicrobial peptide protegrin I (PG-1) and the ... The host defense antimicrobial peptide protegrin I (PG-1), exhibits broad-spectrum antimicrobial activity and good activity ... "Macrocyclic hairpin mimetics of the cationic antimicrobial peptide protegrin I: a new family of broad‐spectrum antibiotics". ... "Properties and structure-activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide ...
https://en.wikipedia.org/wiki/Murepavadin
CyanaseCyanase
... that as a novel cationic α-helical antimicrobial peptide, known by CL 14-25. Cyanase is also important as an energy metabolizer ... "Antimicrobial activity and mechanism of action of a novel cationic α-helical dodecapeptide, a partial sequence of cyanate lyase ... doi:10.1016/j.peptides.2012.12.015. PMID 23270672. S2CID 56770. Palatinszky M, Herbold C, Jehmlich N, Pogoda M, Han P, von ...
https://en.wikipedia.org/wiki/Cyanase
PseudinPseudin
... is a peptide derived from Pseudis paradoxa. Pseudins have some antimicrobial function. There are several different ... Its secondary/tertiary structure consists of one cationic amphipathic α-helix. Pseudin-2 was shown to have potent antibacterial ... Olson, L.; Soto, A. M.; Knoop, F. C.; Conlon, J. M. (2001-11-09). "Pseudin-2: an antimicrobial peptide with low hemolytic ... ISBN 0-85404-242-3. Rinaldi AC (2002). "Antimicrobial peptides from amphibian skin: an expanding scenario". Curr Opin Chem Biol ...
https://en.wikipedia.org/wiki/Pseudin
Histone H2AHistone H2A
Antimicrobial peptide: Histones are conserved eukaryotic cationic proteins present in the cells and are involved in the ... Histone H2A variant is reported to be involved in host immune response by acting as antimicrobial peptides (AMPs). H2A are α- ... "An unconventional antimicrobial protein histone from freshwater prawn Macrobrachium rosenbergii: analysis of immune properties ... amphipathic protein with hydrophobic and hydrophilic residues on opposing sides that enhances the antimicrobial activity of H2A ...
https://en.wikipedia.org/wiki/Histone_H2A
Azurocidin 1Azurocidin 1
Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is ... Pereira HA, Erdem I, Pohl J, Spitznagel JK (1993). "Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil ... "Entrez Gene: AZU1 azurocidin 1 (cationic antimicrobial protein 37)". Soehnlein, Oliver; Lindbom, Lennart (2009). "Neutrophil- ... granule-associated cationic antimicrobial protein chemotactic for monocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4733-7. ...
https://en.wikipedia.org/wiki/Azurocidin_1
Alpha helixAlpha helix
Common to many of them is that the hydrophobic face of the antimicrobial peptide forms pores in the plasma membrane after ... "Role of Cationic Side Chains in the Antimicrobial Activity of C18G". Molecules. 23 (2): 329. doi:10.3390/molecules23020329. PMC ... This pattern is especially common in antimicrobial peptides, and many models have been devised to describe how this relates to ... Toke, Orsolya (2005). "Antimicrobial peptides: new candidates in the fight against bacterial infections". Biopolymers. 80 (6): ...
https://en.wikipedia.org/wiki/Alpha_helix
Beta defensinBeta defensin
"Tracheal antimicrobial peptide, a novel cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of ... Making non-oxidative mechanisms, such as lysosomes and cationic peptides, even more important. β-defensins genes are found ... The first beta-defensin discovered was Tracheal Antimicrobial Peptide, found in the bovine airway in 1991. The first human beta ... When the receptors are activated a cascade reaction will take place and substances such as cytokines and antimicrobial peptides ...
https://en.wikipedia.org/wiki/Beta_defensin
Beta-defensin 2Beta-defensin 2
Human beta-defensin-2 (hBD-2) is a cysteine-rich cationic low molecular weight antimicrobial peptide recently discovered in ... Beta-defensin 2 (BD-2) also known as skin-antimicrobial peptide 1 (SAP1) is a peptide that in humans is encoded by the DEFB4 ( ... Carothers DG, Graham SM, Jia HP, Ackermann MR, Tack BF, McCray PB (2001). "Production of beta-defensin antimicrobial peptides ... Weinberg A, Krisanaprakornkit S, Dale BA (1999). "Epithelial antimicrobial peptides: review and significance for oral ...
https://en.wikipedia.org/wiki/Beta-defensin_2
GDF2GDF2
... is a potent inducer of hepcidin (a cationic peptide that has antimicrobial properties) in liver cells (hepatocytes) and ... GDF2 contains an N-terminal TGF-beta-like pro-peptide (prodomain) (residues 56-257) and a C-terminal transforming growth factor ...
https://en.wikipedia.org/wiki/GDF2
DEFA5DEFA5
Defensins are a family of microbicidal and cytotoxic peptides (antimicrobial peptides; AMP) that are involved in host defense, ... Defensins are small cationic peptides linked via three intra-molecular disulfide bridges, and contain six intra-molecular ... Bevins CL, Salzman NH (May 2011). "Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis". Nature ... implications for antimicrobial peptides in host defense of the human bowel". FEBS Letters. 315 (2): 187-92. doi:10.1016/0014- ...
https://en.wikipedia.org/wiki/DEFA5
Alveolar macrophageAlveolar macrophage
These organelles contain a myriad of degradative enzymes and antimicrobial peptides that are released into the phagolysosome, ... and on the synthesis of toxic cationic polypeptides. Macrophages possess a repertoire of antimicrobial molecules packaged ... Normally mature TGFβ is secreted as a latent complex with its N-terminal fragment, latency-associated peptide (LAP), which ... such as proteases, nucleases, phosphatases, esterases, lipases, and highly basic peptides. Moreover, macrophages possess a ...
https://en.wikipedia.org/wiki/Alveolar_macrophage
Class II bacteriocinClass II bacteriocin
It includes the alpha enterocins and lactococcin G peptides. These peptides have some antimicrobial properties; they inhibit ... This cationic N-terminal beta-sheet domain mediates binding of the class IIa bacteriocin to the target cell membrane. The C- ... Fimland G, Nissen-Meyer J, Johnsen L (2005). "The C-terminal domain of pediocin-like antimicrobial peptides (class IIa ... Dalhus B, Fimland G, Nissen-Meyer J, Johnsen L (2005). "Pediocin-like antimicrobial peptides (class IIa bacteriocins) and their ...
https://en.wikipedia.org/wiki/Class_II_bacteriocin
Lipid A acylaseLipid A acylase
PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response. Hwang PM, ... Antimicrobial peptide resistance and lipid A acylation protein PagP is a family of several bacterial antimicrobial peptide ...
https://en.wikipedia.org/wiki/Lipid_A_acylase
Staphylococcus schleiferiStaphylococcus schleiferi
... antimicrobial therapeutic agents and is thought to also provide protection against host defense cationic antimicrobial peptides ... Antimicrobial therapy has been generally successful in treatment of infections, however, resistance to beta-lactam antibiotics ... Although the current antimicrobials commonly used for treatment of S. schleiferi caused infections experimentally show ... Owners of dogs affected by deep pyoderma carried multiple anti-microbial resistant strains of S. intermedius which is thought ...
https://en.wikipedia.org/wiki/Staphylococcus_schleiferi
Formyl peptide receptor 2Formyl peptide receptor 2
Cathelicidin-related antimicrobial peptides, numerous Pleurocidins which are a family of cationic antimicrobial peptides found ... which is a frog-derived antimicrobial peptide ((pro-inflammatory products derived from host anti-microbial proteins); and j) ... Eicosanoid receptor Formyl peptide receptor Lipoxin Resolvin Formyl peptide receptor 1 Formyl peptide receptor 3 GRCh38: ... Pundir P, Catalli A, Leggiadro C, Douglas SE, Kulka M (Jan 2014). "Pleurocidin, a novel antimicrobial peptide, induces human ...
https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2
HistatinHistatin
... s are histidine-rich (cationic) antimicrobial proteins found in saliva. Histatin's involvement in antimicrobial ... v t e (Articles with short description, Short description matches Wikidata, Membrane proteins, Antimicrobial peptides, All stub ... ISBN 978-1-55581-539-4. Kavanagh K, Dowd S (March 2004). "Histatins: antimicrobial peptides with therapeutic potential" (PDF). ... Swidergall, Marc; Ernst, Joachim F. (August 2014). "Interplay between Candida albicans and the Antimicrobial Peptide Armory". ...
https://en.wikipedia.org/wiki/Histatin
ArenicinArenicin
"NZ17074 - A Novel antimicrobial peptide showing potent in vitro activity against gram negative multi-resistant clinical ... Cationic residues on arenicin-3 interacts with negatively charged lipopolysaccharides on the outer membrane of Gram-negative ... Arenicins are a group of antimicrobial peptides being studied to combat Gram-negative bacteria. The arenicin family consists of ... a novel antimicrobial peptide from marine polychaeta Arenicola marina". FEBS Letters. 577 (1-2): 209-14. doi:10.1016/j.febslet. ...
https://en.wikipedia.org/wiki/Arenicin
Innate immune systemInnate immune system
Antimicrobial peptides are an evolutionarily conserved component of the innate immune response found among all classes of life ... can cause lysis of many Gram-positive bacteria by acting as a cationic detergent. Many acute-phase proteins of inflammation are ... Several species of insect produce antimicrobial peptides known as defensins and cecropins. In invertebrates, PRRs trigger ... In addition, some of the products of the coagulation system are directly antimicrobial. For example, beta-lysine, a protein ...
https://en.wikipedia.org/wiki/Innate_immune_system
CathelicidinCathelicidin
Antimicrobial peptides Innate immune system Peptoid "Entrez Gene: CAMP cathelicidin antimicrobial peptide". UniProt entry: ... "Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human ... The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). The AMP family also includes the defensins ... a synthetic antimicrobial and antibiofilm peptide) is a modified version of LL-37 that has enhanced antimicrobial activities ...
https://en.wikipedia.org/wiki/Cathelicidin
LacritinLacritin
... and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification". J Proteome Res. 14 (6): 2649- ... that likely interacts with the cationic face of lacritin's C-terminal amphipathic alpha helix), and an N-terminal chondroitin ... Each peptide inserts rapidly into (O-acyl)-omega-hydroxy fatty acid (OAHFA) thought to reside at the aqueous lipid boundary in ... In both cases, stability is largely restored by spiking in synthetic lacritin peptides N-94 or N-94/C-6 as proxy C-terminal ...
https://en.wikipedia.org/wiki/Lacritin
GranulocyteGranulocyte
Antimicrobial agents (Defensins and Eosinophil cationic protein) Enzymes Acid hydrolases: further digest bacteria Lysozyme: ... vasoactive intestinal peptide (VIP), vascular endothelial growth factor (VEGF), TNF, prostaglandins, leukotrienes, and ... Neutrophils have three strategies for directly attacking micro-organisms: phagocytosis (ingestion), release of soluble anti- ... Primary granules contain cationic proteins and defensins that are used to kill bacteria, proteolytic enzymes and cathepsin G to ...
https://en.wikipedia.org/wiki/Granulocyte
AmphiphileAmphiphile
Antimicrobial peptides (AMPs) are another class of amphiphilic molecules, a big data analysis showed that amphipathicity best ... Some typical members of this group are: sodium dodecyl sulfate (anionic), benzalkonium chloride (cationic), cocamidopropyl ... of antimicrobial activities in relation to amphipathicity and charge reveals novel characterization of antimicrobial peptides ... Schubert, D; Behl, C; Lesley, R; Brack, A; Dargusch, R; Sagara, Y; Kimura, H (14 March 1995). "Amyloid peptides are toxic via a ...
https://en.wikipedia.org/wiki/Amphiphile
VancomycinVancomycin
The three peptide syntheses are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis ... Vancomycin activity is considered to be time-dependent; that is, antimicrobial activity depends on the duration that the serum ... re-gained the antibacterial power of vancomycin by modifying the molecule with a cationic oligopeptide. The oligopeptide ... Nonribosomal peptide synthesis occurs through distinct modules that can load and extend the protein by one amino acid per ...
https://en.wikipedia.org/wiki/Vancomycin
PardaxinPardaxin
This article incorporates text from the public domain Pfam and InterPro: IPR009990 (Protein families, Antimicrobial peptides). ... Its 33-amino acid structure contains many cationic and amphipathic amino acids. This makes it easier for it to interact with ... Yeaman MR, Yount NY (March 2003). "Mechanisms of antimicrobial peptide action and resistance". Pharmacological Reviews. 55 (1 ... Oren Z, Shai Y (April 1996). "A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide ...
https://en.wikipedia.org/wiki/Pardaxin
Pseudomonas aeruginosaPseudomonas aeruginosa
... compensates for a lack of lipopolysaccharide aminoarabinose modification-dependent resistance to the antimicrobial peptide ... September 2015). "Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm ... Combination therapy after rigorous antimicrobial susceptibility testing has been found to be the best course of action in the ... Use of β-lactamase inhibitors such as sulbactam has been advised in combination with antibiotics to enhance antimicrobial ...
https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa
SurfactinSurfactin
doi:10.1016/0927-7765(94)01183-6. Mor, A. Peptide-based antibiotics: A potential answer to raging antimicrobial resistance. ... The pore-forming (ion channel) effect is characterized by the formation of cationic channels. It would require surfactin to ... The structure of the main congener consists of a peptide loop of seven amino acids (L-glutamic acid, L-leucine, D-leucine, L- ... ISBN 978-0-683-00603-2. Heerklotz H, Seelig J (September 2001). "Detergent-like action of the antibiotic peptide surfactin on ...
https://en.wikipedia.org/wiki/Surfactin
Irshad HussainIrshad Hussain
Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria' ACS Omega, 2018. 'Metal ... Rational and combinatorial design of peptide capping ligands for gold nanoparticles' JACS, 2004. 'Emulsion-templated gold beads ... "Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria". ACS Omega. 3 (12): 16721-16727. ... "Rational and Combinatorial Design of Peptide Capping Ligands for Gold Nanoparticles". Journal of the American Chemical Society ...
https://en.wikipedia.org/wiki/Irshad_Hussain
StainingStaining
Acridine orange (AO) is a nucleic acid selective fluorescent cationic dye useful for cell cycle determination. It is cell- ... Collagen Hybridizing Peptide (CHP) staining allows for an easy, direct way to stain denatured collagens of any type (Type I, II ... "Impact of Reporting Gram Stain Results From Blood Cultures on the Selection of Antimicrobial Agents". American Journal of ... Safranine (or Safranine O) is a red cationic dye. It binds to nuclei (DNA) and other tissue polyanions, including ...
https://en.wikipedia.org/wiki/Staining
CupienninCupiennin
They are chemically cationic α-helical peptides. They were isolated and identified in 2002 as a family of peptides called ... a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae)". J Biol Chem. 277 ( ... These peptides are highly cationic, made up of similar amino acids, but different in the N- and C-terminal ends. The ... Cupiennin 1 family is the more well-known group, and consists of at least four peptides, such as cupiennin 1a, 1b, 1c, and 1d. ...
https://en.wikipedia.org/wiki/Cupiennin
CliotideCliotide
Butelase 1 is the fastest peptide ligase known capable of catalyzing peptide cyclization at an extraordinary efficiency. Nguyen ... At a concentration of 1 μM, cationic cliotides are capable of augmenting the secretion of various cytokines and chemokines in ... Cliotides display in vitro antimicrobial activity against E. coli, K. pneumoniae, and P. aeruginosa and cytotoxicity against ... Cliotides are a group of related peptides that have been isolated from the heat-stable fraction of Clitoria ternatea (Cliotides ...
https://en.wikipedia.org/wiki/Cliotide
ThiomerThiomer
Because of their antimicrobial activity, thiolated polymers are also used as coatings that avoid bacterial adhesion. Thiomers ... Many non-invasively administered drugs such as therapeutic peptides or nucleic acids are degraded on the mucosa by membrane ... Priya, SS; Rekha, MR (2016). "Disulphide cross linked pullulan based cationic polymer for improved gene delivery and efflux ... potential excipients for non-invasive peptide delivery systems". Eur. J. Pharm. Biopharm. 58 (2): 253-263. doi:10.1016/j.ejpb. ...
https://en.wikipedia.org/wiki/Thiomer
ColistinColistin
... is a polycationic peptide and has both hydrophilic and lipophilic moieties. These cationic regions interact with the ... Pamp SJ, Gjermansen M, Johansen HK, Tolker-Nielsen T (2008). "Tolerance to the antimicrobial peptide colistin in Pseudomonas ... Non-ribosomal peptide biosynthesis begins with a loading module and then the addition of each subsequent amino acid. The ... This continues with each amino acid until the linear peptide chain is completed. The last module will have a thioesterase to ...
https://en.wikipedia.org/wiki/Colistin
Browsing SEARO Publications by Subject Antimicrobial Cationic PeptidesBrowsing SEARO Publications by Subject "Antimicrobial Cationic Peptides"
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. ... Situation analysis on antimicrobial resistance in the South-East Asia Region: Report 2016  ...
https://apps.who.int/iris/handle/10665/136791/browse?authority=Antimicrobial+Cationic+Peptides&type=mesh
Browsing by Subject Antimicrobial Cationic PeptidesBrowsing by Subject "Antimicrobial Cationic Peptides"
Situation analysis on antimicrobial resistance in the South-East Asia Region: Report 2016  ... "Antimicrobial Cationic Peptides". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
https://extranet.who.int/iris/restricted/browse?authority=Antimicrobial+Cationic+Peptides&type=mesh
Dryad Data -- A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by...Dryad Data -- A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by...
The raw data of "A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by ... Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing ... 2018), Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by ... Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants ...
https://datadryad.org/stash/dataset/doi:10.5061/dryad.2sv68
Antimicrobial Cationic Peptides | Profiles RNS
"Antimicrobial Cationic Peptides" by people in this website by year, and whether "Antimicrobial Cationic Peptides" was a major ... Antimicrobial Cationic Peptides*Antimicrobial Cationic Peptides. *Cationic Peptides, Antimicrobial. *Peptides, Antimicrobial ... "Antimicrobial Cationic Peptides" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Antimicrobial Cationic Peptides" by people in Profiles. ...
https://profiles.rush.edu/display/14772
Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant...Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant...
Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial Peptides (CAMPs) ... Table 1 In vitro antibacterial activity of cationic antimicrobial peptides against methicillin-resistant and -susceptible S. ... Cationic Antimicrobial Peptides (CAMPs) appear to be promising candidates to overcome resistance [15,16,17]. CAMPs are a large ... Hancock R. Review Cationic peptides : effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 2001;1 October: ...
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-019-1416-8
TCDB » SuperfamiliesTCDB » Superfamilies
Ciumac D, Gong H, Hu X, Lu JR (2018). Membrane targeting cationic antimicrobial peptides. J Colloid Interface Sci 537: 163-185 ... 1.C.76 - The Pore-forming Maculatin Peptide (Maculatin) Family. 1.C.124 - The Antimicrobial Pore-forming Pandinin (Pin) Family ... 2012). Natural antimicrobial peptides from bacteria: characteristics and potential applications to fight against antibiotic ... 8.B.7 - The Cl- Channel Peptide Inhibitor (GaTx1) Family. 8.B.8 - The α-KTx15 scorpion toxin (α-KTx15) Family. ...
https://tcdb.org/superfamily.php
Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages - NRC Publications...Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages - NRC Publications...
Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages ... Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages. DOI. Resolve DOI: ... Effects of linear cationic a-helical antimicrobial peptides on immune-relevant genes in trout macrophages. From National ... Overall, the data indicate a pro-inflammatory effect of the three cationic antimicrobial peptides in the inflammatory response ...
https://publications-cnrc.canada.ca/eng/view/object/?id=026042b2-5ec2-4e88-9616-60f8be0b8b77
Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: Application to the...
Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition.pdf non disponibili ... Cationic antimicrobial peptides (CAMPs) are essential components of innate immunity. Here we show that antimicrobial potency of ... Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: Application to the ... Cationic antimicrobial peptides (CAMPs) are essential components of innate immunity. Here we show that antimicrobial potency of ...
https://www.iris.unina.it/handle/11588/666704
DeCS - Termos NovosDeCS - Termos Novos
ANTIMICROBIAL CATIONIC PEPTIDES. PEPTIDOS CATIONICOS ANTIMICROBIANOS. PLEISTOPHORA. PLEISTOPHORA. PLEISTOPHORA. PORO NUCLEAR. ...
https://decs.bvs.br/P/news2001pie.htm
Chemerin is an antimicrobial agent in human epidermisChemerin is an antimicrobial agent in human epidermis
Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that ... Antimicrobial Cationic Peptides / chemistry * Antimicrobial Cationic Peptides / genetics * Antimicrobial Cationic Peptides / ... Chemerin is an antimicrobial agent in human epidermis PLoS One. 2013;8(3):e58709. doi: 10.1371/journal.pone.0058709. Epub 2013 ... Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that ...
https://pubmed.ncbi.nlm.nih.gov/23527010/?dopt=Abstract
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Antimicrobial Cationic Peptides Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Antimicrobial+Cationic+Peptides&parentid=19642&catid=38324
TNRTNR
Antimicrobial cationic peptides (AMPs) are ubiquitous little proteins utilized by living. immune Uncategorized Ki8751, TNR ... Antimicrobial cationic peptides (AMPs) are ubiquitous little proteins utilized by living cells to guard against a broad ... through the production of antimicrobial peptides (AMPs) [30,31] that have a wide distribution from microorganisms to complex ...
http://www.immune-source.com/tag/tnr/
KEGG COMPOUND: C00346
Cationic antimicrobial peptide (CAMP) resistance. map04071 Sphingolipid signaling pathway. Module. M00092 ...
https://www.genome.jp/entry/C00346
Browsing Science (Faculty of) by Subject ProteinsBrowsing Science (Faculty of) by Subject "Proteins"
Opposing effects of cationic antimicrobial peptides and divalent cations on bacterial lipopolysaccharides  Smart, Matthew; ...
https://uwspace.uwaterloo.ca/handle/10012/9936/browse?type=subject&value=Proteins
Toxins | Free Full-Text | Antimicrobial Properties of Apis melliferas Bee VenomToxins | Free Full-Text | Antimicrobial Properties of Apis mellifera's Bee Venom
It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds ... The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The ... To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of ... this review is to address the antimicrobial properties of BV and its compounds. ...
https://www.mdpi.com/2072-6651/12/7/451/htm
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis |...CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis |...
Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur. J. Immunol. 45, 203-213 ... Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J. Exp. Med. 206, 1983-1994 ( ... Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. Nat. Commun. 10, 1012 ( ... Lee, E. Y., Lee, M. W. & Wong, G. C. L. Modulation of toll-like receptor signaling by antimicrobial peptides. Semin. Cell Dev. ...
https://www.nature.com/articles/s41467-019-09683-z?error=cookies_not_supported&code=8b89597e-c9b8-4c13-bf3c-80a3698914e1
Biblio | Linus Pauling Institute | Oregon State UniversityBiblio | Linus Pauling Institute | Oregon State University
Antimicrobial Cationic Peptides. Jiang J, Zhang Y, Indra AK, Ganguli-Indra G, Le MN, Wang H, Hollins RR, Reilly DA, Carlson MA ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ... 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression.. Nanomedicine (Lond ...
https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=2681&o=asc&s=keyword
Immunotherapy for Pulmonary TBImmunotherapy for Pulmonary TB
Table 1. Relevance of antimicrobial peptides in TB. Antimicrobial peptide. Source. Activity. Importance in TB. Ref.. ... AMPs are small cationic molecules of a variable length. These peptides mainly constitute polar-hydrophilic, nonpolar- ... The use of antimicrobial peptides (AMPs) and AMP inducers are a promising option for the immunotherapy of TB by using them as ... Induction of this antimicrobial peptide reduce mycobacterial loads. [22,25,41,55,78]. ...
https://www.medscape.com/viewarticle/817431_2
Hansen, Jørn H | UiTHansen, Jørn H | UiT
Development and Evaluation of Cationic Amphiphilic Antimicrobial 2,5-Diketopiperazines Journal of Peptide Science 2018 DOI ...
https://uit.no/ansatte/person?p_document_id=317677
Gillian Morrison - Fingerprint - University of Edinburgh Research Explorer
Antimicrobial Cationic Peptides 13% * beta-Defensins 100% * Brain Neoplasms 17% * Burkholderia cepacia 11% ...
https://www.research.ed.ac.uk/en/persons/gillian-morrison/fingerprints/?sortBy=alphabetically
Design and Application of Antimicrobial Peptide Conjugates - Kölner UniversitätsPublikationsServerDesign and Application of Antimicrobial Peptide Conjugates - Kölner UniversitätsPublikationsServer
CELL-PENETRATING PEPTIDE; GRAM-NEGATIVE BACTERIA; CATIONIC PEPTIDES; ANTIBACTERIAL PEPTIDES; ESCHERICHIA-COLI; AMINO-ACID; ... Design and Application of Antimicrobial Peptide Conjugates. Int. J. Mol. Sci., 17 (5). BASEL: MDPI. ISSN 1422-0067 ... Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and ... AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years ...
https://kups.ub.uni-koeln.de/27610/
Utilisation of peptides against microbial infections - a review Utilisation of peptides against microbial infections - a review
Antimicrobial peptides (AMPs) seem to meet these expectations. AMPs are produced by bacteria, viruses, plants, and animals, and ... The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. ... Cationic antimicrobial peptides: towards clinical applications. Expert Opin Investig Drugs. 2000; 9(8): 1723-1729. ... Antimicrobial peptides may be applied topically and systemically. Among the peptides used topically, a very important area for ...
https://www.aaem.pl/Utilisation-of-peptides-against-microbial-infections-a-review,74471,0,2.html
KEGG T01145: ROD 44461KEGG T01145: ROD 44461
09175 Drug resistance: antimicrobial. 01503 Cationic antimicrobial peptide (CAMP) resistance. ROD_44461 (ppiA). 09180 Brite ...
https://www.kegg.jp/entry/cro:ROD_44461
Author: maria / Subject term: chloramphenicol - PubAg Search ResultsAuthor: maria / Subject term: chloramphenicol - PubAg Search Results
The cationic antimicrobial peptides present a promise to be used to develop more efficient drugs applied to human health. The ... antimicrobial cationic peptides; chloramphenicol; drugs; genetic databases; genome; genomics; human health; humans; ... Predicting antimicrobial peptides from eukaryotic genomes: In silico strategies to develop antibiotics ... Antimicrobial resistance (AMR) is a growing global public health problem, which is caused by the use of antimicrobials in both ...
https://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=chloramphenicol&per_page=100&q=maria&search_field=author&sort=date-desc
Frontiers | Soluble Mediators Regulating Immunity in Early LifeFrontiers | Soluble Mediators Regulating Immunity in Early Life
The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, ... The complement system, antibodies, and antimicrobial proteins and peptides (APPs), can directly interact with potential ... The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and ... Anti-Microbial Proteins and Peptides. Anti-microbial proteins and peptides play a critical role in innate immunity by directly ...
https://www.frontiersin.org/articles/10.3389/fimmu.2014.00457/full
Portal LIS - Localizador de Informação em SaúdePortal LIS - Localizador de Informação em Saúde
Health Education, Antimicrobial Cationic Peptides, Adaptive Immunity, Immunity, Innate, Database UniProt - Universal Protein ...
https://bvsalud.org/portal-lis/en/lis-search/?q=source_type%3Adatabases_gene_sequences
British Library EThOS: Bioinformatics approaches to structure and function of antimicrobial peptidesBritish Library EThOS: Bioinformatics approaches to structure and function of antimicrobial peptides
Their activity is determined by numerous properties such as cationic charge, amphipathicity, size, and amino acid composition. ... Antimicrobial peptides (AMPs) are among the leading alternatives to current antibiotics, exhibiting broad spectrum activity. ... Antimicrobial resistance within a wide range of infectious agents is a severe and growing public health threat. ... The results presented in this work give an overview of the range of protein scaffolds that naturally bear antimicrobial ...
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.784873
RCSB PDB - 2L3I: Oxki4a, spider derived antimicrobial peptideRCSB PDB - 2L3I: Oxki4a, spider derived antimicrobial peptide
A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius ( ... AOXKI4A, antimicrobial peptide in spider venom. A. 30. Oxyopes takobius. Mutation(s): 0 Membrane Entity: Yes ... A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius ( ... Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin.. Dubovskii, P.V., ...
https://www.rcsb.org/structure/2L3I
Crucial roles of charged saccharides in the survival of Gram-negative bacteriaCrucial roles of charged saccharides in the survival of Gram-negative bacteria
For example, cationic antimicrobial peptides (CAPs) have drawn increasing attention as alternatives to chemical food ... LPSs are supposed to play crucial roles in the survival of bacteria against antimicrobial peptides. This finding inspires the ... and divalent cations on the survival of Gram-negative bacteria against cationic peptides like protamine. As the minimal ...
https://esrf.fr/cms/live/live/en/sites/www/home/UsersAndScience/Publications/Highlights/2010/scm/scm05.html
ResistanceAMPsBroad-spectrumGRAM-NEGATIVEDefensinsProteinsAntibioticsEndogenousInflammatory responseBacterialSyntheticHumansSignal peptideHemolytic activityCompoundsMembraneActivityXenopusHydrophobicInsectMicroorganismsCathelicidinMimicDefenseCAMPsInfectionsVivoDrugsClinicalMeSHIntramolecularViralInhibitorsCellsCompositionBindsVenomImmuneMolecularSmallActiveInfectionPropertiesMinimalOwingCircularFindingsSignificantly
Resistance11
  • P. aeruginosa infections are often severe, life threatening and difficult to treat because of the limited susceptibility to antimicrobial agents due to the numerous mechanisms of resistance that this organism has accumulated [ 13 ]. (biomedcentral.com)
  • The slope of the regression line describing the correlation 'antimicrobial potency'/'C(m)H(n)L product' changes from strain to strain indicating that some strains acquired a higher resistance to CAMPs than others. (unina.it)
  • Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. (uni-koeln.de)
  • The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. (aaem.pl)
  • The limitations in the use of peptides in the treatment of infections, such as susceptibility to proteolysis, and resistance of microorganisms to the peptides, are also discussed. (aaem.pl)
  • As the presence of antibiotics in environmental waters enhances antimicrobial resistance, photolysis and heterogeneous photocatalysis of chloramphenicol (CAP) were evaluated in deionized water (DW) and in sewage treatment plant (STP) effluent under black light and solar irradiation. (usda.gov)
  • Antimicrobial resistance within a wide range of infectious agents is a severe and growing public health threat. (bl.uk)
  • Summary: Emergence of resistance to the antibiotics currently employed in clinical practice is a continual stimulus for further research aimed at identifying novel antimicrobial compounds. (elsevier.com)
  • Health care personnel must appreciate that only judicious use of antimicrobial drugs will prevent the further uncontrolled spread of bacterial resistance. (elsevier.com)
  • Numerous antimicrobial protocols are used to treat PRRS, but we have little insight into how these treatment schemes impact antimicrobial resistance (AMR) dynamics within the fecal microbiome of commercial swine. (biomedcentral.com)
  • Antimicrobial resistance gene (ARG) richness and diversity were significantly higher at earlier time points, while microbiome richness and diversity were significantly lower. (biomedcentral.com)
AMPs10
  • Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants, non-mammalian vertebrates, and mammals. (datadryad.org)
  • AMPs are small cationic molecules of a variable length. (medscape.com)
  • [ 1 ] AMPs are broadly distributed in nature and all of them share fundamental structural characteristics that are very important for their broad-spectrum antimicrobial activity, such as length (less than 60 amino acids), amphipathic structure and the presence of cationic amino acids in their structure, providing them with a partial positive charge. (medscape.com)
  • However, due to their secondary structural characteristics, AMPs could be divided into subcategories that include: α-helical, peptides enriched with repetition of one amino acid, and peptides with intramolecular bonding formed by cysteines. (medscape.com)
  • AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. (uni-koeln.de)
  • Antimicrobial peptides (AMPs) seem to meet these expectations. (aaem.pl)
  • Antimicrobial peptides (AMPs) are among the leading alternatives to current antibiotics, exhibiting broad spectrum activity. (bl.uk)
  • The results presented in this work give an overview of the range of protein scaffolds that naturally bear antimicrobial activity, give an insight into AMPs' interactions with bacterial membrane and are a step forward in protein design efforts towards better AMPs. (bl.uk)
  • One common feature among cationic AMPs is an amidated C-terminus that provides greater stability against in vivo degradation. (edu.au)
  • The amphibian temporins, amongst the smallest antimicrobial peptides (AMPs), are α-helical, amphipathic, hydrophobic and cationic and are active mainly against Gram-positive bacteria but inactive or weakly active against Gram-negative bacteria. (qub.ac.uk)
Broad-spectrum5
  • Synthetic Oxt 4a was produced and shown to possess strong and broad-spectrum cytolytic and antimicrobial activity. (rcsb.org)
  • Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. (uncg.edu)
  • Broad-spectrum antimicrobials used to be the most common therapy to achieve a certain control on infections. (dovepress.com)
  • Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. (peprotech.com)
  • We have previously reported that a C60 fullerene functionalized with three dimethylpyrrolidinium groups (BF6) is a highly active broad-spectrum antimicrobial photosensitizer in vitro when combined with white-light illumination. (perkinelmer.com)
GRAM-NEGATIVE2
  • Since the removal or mutation of LPSs is known to result in the death of Gram-negative bacteria, LPSs are supposed to play crucial roles in the survival of bacteria against antimicrobial peptides. (esrf.fr)
  • Here we reveal the influence of molecular structure (genetic mutation) and divalent cations on the survival of Gram-negative bacteria against cationic peptides like protamine. (esrf.fr)
Defensins3
  • Defensins are cationic peptides, produced by various human tissues, which serve as antimicrobial effectors of the immune system. (uni-konstanz.de)
  • Plant defensins are small cationic peptides with antimicrobial activity and are integral part of the plant innate immune system. (edu.au)
  • Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides), which include cathelicidins and defensins, are key components of the innate immune system that are upregulated during infection and inflammation. (cdc.gov)
Proteins5
  • The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, protecting against systemic infection. (frontiersin.org)
  • Additionally, several classes of proteins, including immunoglobulins (Igs), the complement system, and anti-microbial proteins and peptides (APPs), aid in the innate response to invading microorganisms and display age-dependent maturation (Figure 1 ). (frontiersin.org)
  • Lower levels of complement proteins and anti-microbial proteins and peptides contribute to neonatal susceptibility to infection, while elevated levels of adenosine, adiponectin, and adrenomedullin in neonatal blood may influence immune cell polarization. (frontiersin.org)
  • Scientists have been studying proteins produced by animals and humans, called cationic antimicrobial peptides (CAMPs), that the body uses to fight off infections. (harvard.edu)
  • Salivary amylase, mucins, statherin, cystatins, and several cationic peptides are other proteins in saliva that form part of the innate immune system. (myassignmenthelp.com)
Antibiotics3
  • Methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic Antimicrobial Peptides (CAMPs) represent promising alternatives. (biomedcentral.com)
  • Hancock RE, Lehrer R. Cationic peptides: a new source of antibiotics. (aaem.pl)
  • For example, cationic antimicrobial peptides (CAPs) have drawn increasing attention as alternatives to chemical food preservatives and commonly used antibiotics. (esrf.fr)
Endogenous2
  • 2018. 1α,25-dihydroxyvitamin D-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression. . (oregonstate.edu)
  • Fpn activity is suppressed by hepcidin, an endogenous peptide hormone, which inhibits iron export and promotes endocytosis of Fpn. (bvsalud.org)
Inflammatory response2
  • Overall, the data indicate a pro-inflammatory effect of the three cationic antimicrobial peptides in the inflammatory response of salmonid species, suggesting a potential application of these peptides as immune adjuvant for fish vaccination. (canada.ca)
  • Although at the beginning it was thought that these functions were only focused to promote proinflammatory conditions, it is now well known that some peptides, such as cathelicidin have ambiguous functions promoting, in certain cases, an anti-inflammatory response as well. (medscape.com)
Bacterial3
  • Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis. (nih.gov)
  • In swine, a major driver of antimicrobial use is porcine reproductive and respiratory syndrome (PRRS), which is caused by a virus that predisposes infected animals to secondary bacterial infections. (biomedcentral.com)
  • We used maculatin 1.1 (Mac1) to assess the role of the capping groups in modulating the peptide bacterial efficiency, stability and interactions with lipid membranes. (edu.au)
Synthetic3
  • A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). (nih.gov)
  • 2008. Investigating the effect of increasing charge density on the hemolytic activity of synthetic antimicrobial polymers. . (umass.edu)
  • 2008. Synthetic mimic of antimicrobial peptide with nonmembrane-disrupting antibacterial properties. . (umass.edu)
Humans1
  • Phenotypic, genotypic, and antimicrobial characteristics of Streptococcus halichoeri isolates from humans, proposal to rename Streptococcus halichoeri as Streptococcus halichoeri subsp. (cdc.gov)
Signal peptide1
  • Lamprey albumin contains a 23-amino acid putative signal peptide and a 6-residue putative propeptide, which, when cleaved, yield a mature protein of 1,394 amino acids with a calculated molecular weight of 157,000. (embl.de)
Hemolytic activity1
  • The cationic β-sheet cyclic tetradecapeptide cyclo[VKLdKVdYPLKVKLdYP] (GS14dK 4 ) is a diastereomeric lysine ring-size analog of the potent naturally occurring antimicrobial peptide gramicidin S (GS) which exhibits enhanced antimicrobial but markedly reduced hemolytic activity compared to GS itself. (elsevier.com)
Compounds2
  • Purpose of review: In this review, we highlight some of the developments achieved over the past 2 years in the field of novel antimicrobial compounds. (elsevier.com)
  • A number of natural compounds including enzymes, essential oils, peptides, and chelators possess antimicrobial properties and are safe for human consumption. (naturalmedicinejournal.com)
Membrane5
  • They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. (uni-koeln.de)
  • Mihajlovic M, Lazaridis T. Antimicrobial peptides bind more strongly to membrane pores. (aaem.pl)
  • Amphiphilic cationic ß 3R3 -peptides: membrane active peptidomimetics and their potential as antimicrobial agents. (mpg.de)
  • Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membrane of microbes. (edu.au)
  • Finally, we demonstrate that the affinity of binding of GS14dK4 to various phospholipid bilayer membranes is much more strongly correlated with the antimicrobial and hemolytic activities of this peptide than with its effect on the rate and extent of dye leakage in these model membrane systems. (elsevier.com)
Activity10
  • We demonstrate that it is not only possible to identify and locate with very good precision the position of cryptic peptides, but also to analyze the internal structure of long CAMPs, thus allowing to draw an accurate map of the molecular determinants of their antimicrobial activity. (unina.it)
  • Recombinant chemerin has antimicrobial activity. (nih.gov)
  • This special conformation gives the molecule amphipathic and cationic properties, which are very important for their bactericidal activity. (medscape.com)
  • Berrocal-Lobo M, Molina A, Rodriguez-Palenzuela P, Garcia-Olmedo F, Rivas L. Leishmania donovani: Thionins, plant antimicrobial peptides with leishmanicidal activity. (aaem.pl)
  • Their activity is determined by numerous properties such as cationic charge, amphipathicity, size, and amino acid composition. (bl.uk)
  • The present invention relates to a peptide having antibacterial or anti-inflammatory activity and a pharmaceutical composition containing the same as an active ingredient, and more particularly to a peptide having antibacterial or anti-inflammatory activity against dental bacteria, including periodontal pathogens, and bacteria causing atopic dermatitis, and to a pharmaceutical composition containing the peptide as an active ingredient. (justia.com)
  • The inventive peptide having antibacterial or anti-inflammatory activity can be used for the treatment of both dental infectious diseases, including periodontitis or peri-implantitis, and inflammations, including atopy, psoriasis or arthritis. (justia.com)
  • Antifungal and anti-biofilm activity of the first cryptic antimicrobial peptide from an archaeal protein against Candida spp. (univr.it)
  • The antimicrobial peptide VLL-28, isolated from an archaeal transcription factor, shows comparable antifungal activity against 10 clinical isolates of Candida spp. (univr.it)
  • Antimicrobial surfaces containing cationic nanoparticles: how immobilized, clustered, and protruding cationic charge presentation affects killing activity and kinetics. (umass.edu)
Xenopus1
  • Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. (aaem.pl)
Hydrophobic2
  • The ratio n/(m+n) can vary between ca. 0.5 and 1, thus indicating that some strains are sensitive to highly charged peptides, whereas others are particularly susceptible to more hydrophobic peptides. (unina.it)
  • These peptides mainly constitute polar-hydrophilic, nonpolar-hydrophobic and positively charged amino acids. (medscape.com)
Insect2
  • helical antimicrobial peptides (insect cecropin B, fish pleurocidin and a cecropin analogue CF17). (canada.ca)
  • Zhao W, Lu L, Tang Y. Research and application progress of insect antimicrobial peptides on food industry. (aaem.pl)
Microorganisms1
  • The purpose of this trial was to determine if a combination of naturally occurring antimicrobials can allow reduction and suppression of the invading microorganisms under physiological conditions, so when the combination is given to a patient before eating, the nutrients will be broken down and used by the body, the body will have time to heal, and the probiotics will establish control over the pathogenic bacteria. (naturalmedicinejournal.com)
Cathelicidin2
  • We therefore evaluated the effect of cathelicidin peptides on disease caused by influenza A virus in mice. (cdc.gov)
  • Influenza virus-infected mice treated with LL-37 had lower concentrations of pro-inflammatory cytokines in the lung than did infected animals that had not been treated with cathelicidin peptides. (cdc.gov)
Mimic1
  • Previous studies have shown that small peptides that mimic the first few residues of hepcidin, i.e., minihepcidins, are more potent than hepcidin. (bvsalud.org)
Defense1
  • Unlike other arachnid toxins, Oxt 4a exhibits striking similarity with defense peptides from the skin of ranid frogs that contain the so-called Rana-box motif (a C-terminal disulfide-enclosed loop). (rcsb.org)
CAMPs2
  • Cationic antimicrobial peptides (CAMPs) are essential components of innate immunity. (unina.it)
  • Here we show that antimicrobial potency of CAMPs is linearly correlated to the product C(m)H(n)L where C is the net charge of the peptide, H is a measure of its hydrophobicity and L its length. (unina.it)
Infections4
  • The aim of this study is to review the results of studies on the use of peptides to combat infections in vivo. (aaem.pl)
  • In the combat against systemic infections are used such peptides as: P113D (modified P113 peptide containing D-amino acids), colistin, peptoids, and peptides containing non-typical amino acids or non-peptide elements. (aaem.pl)
  • Antimicrobials are used in food-producing animals for purposes of preventing, controlling, and/or treating infections. (biomedcentral.com)
  • CONCLUSION: These data suggest that cationic fullerenes have clinical potential as an antimicrobial photosensitizer for superficial infections where red light is not needed to penetrate tissue. (perkinelmer.com)
Vivo1
  • In vitro and in vivo experiments suggested that the peptides may act directly on the influenza virion rather than via receptor-based mechanisms. (cdc.gov)
Drugs2
  • Brandenburg L-O, Merres J, Albrecht L-J, Varoga D, Pufe T. Antimicrobial peptides: multifunctional drugs for different applications. (aaem.pl)
  • These drugs will perhaps effectively fight against bacteria that now are scarcely controlled by the traditional antimicrobial agents. (elsevier.com)
Clinical1
  • Eckert R. Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development. (aaem.pl)
MeSH1
  • Antimicrobial Cationic Peptides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Intramolecular1
  • Interestingly, two of the modelled peptides predicted to form β‐hairpins lacked the intramolecular disulphide bonds, cation‐π or aromatic interactions that generally stabilise such AMP structures. (bl.uk)
Viral1
  • Events such as viral illness, antimicrobial exposures, and physical grouping of the pigs exerted significant yet relatively minor influence over this trajectory. (biomedcentral.com)
Inhibitors2
  • Together, this led us to hypothesize that defensin-derived peptides are natural human inhibitors of virus infection with low toxicity. (uni-konstanz.de)
  • Altogether, defensin-derived peptides, in particular HD5(1-9), qualify as promising candidates for further development as a novel class of HCMV entry inhibitors. (uni-konstanz.de)
Cells3
  • and cyclo-oxygenase-2 (COX-2), increased in the peptide-treated RTS11 cells. (canada.ca)
  • In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. (peprotech.com)
  • Using a fluoresceinated derivative of this peptide, we found that VLL-28 binds to the surface of planktonic cells. (univr.it)
Composition1
  • Despite very different antimicrobial exposures after challenge with PRRS virus, resistome composition remained largely similar between the treatment groups. (biomedcentral.com)
Binds1
  • Specifically, this peptide binds much more tightly to anionic than to zwitterionic phospholipids and much less tightly to cholesterol-containing than to cholesterol-free model membranes. (elsevier.com)
Venom1
  • A unique 30-residue cationic peptide oxyopinin 4a (Oxt 4a) was identified in the venom of the lynx spider Oxyopes takobius (Oxyopidae). (rcsb.org)
Immune1
  • There are increasing evidence of the potential role of antimicrobial peptides in the regulation of immune responses in mammalian species. (canada.ca)
Molecular2
  • Deduction of the molecular masses of each mature processed peptide from respective cloned cDNAs was used to locate respective molecules in reverse-phase HPLC fractions of secretion. (qub.ac.uk)
  • 2008. Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach. . (umass.edu)
Small1
  • Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. (rush.edu)
Active1
  • Notably, VLL-28 is the first example of an archaeal antimicrobial peptide that is active towards Candida spp. (univr.it)
Infection1
  • Drug target validation: lethal infection blocked by inducible peptide. (aaem.pl)
Properties1
  • 2009. Antimicrobial polymers prepared by ring-opening metathesis polymerization: manipulating antimicrobial properties by organic counterion and charge density variation. . (umass.edu)
Minimal1
  • To accomplish this, we used a metagenomics approach to characterize and compare the longitudinal wean-to-market resistome and microbiome of pigs challenged with PRRS virus and then exposed to different antimicrobial treatments, and a group of control pigs not challenged with PRRS virus and having minimal antimicrobial exposure. (biomedcentral.com)
Owing1
  • Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry. (uni-koeln.de)
Circular1
  • Circular dichroism results showed that C-terminus amidation maintains the structural stability of the peptide (α-helix) in contact with micelles. (edu.au)
Findings1
  • According to NMR findings, the peptide is disordered in water, but assumes a peculiar torpedo-like structure in detergent micelles. (rcsb.org)
Significantly1
  • Differences in ARG abundance between the groups were mostly driven by temporal changes in abundance that occurred prior to antimicrobial exposures, with the exception of erm G, which increased in the feces of treated pigs, and was significantly more abundant in the feces of these pigs compared to the pigs that did not receive post-PRRS antimicrobials. (biomedcentral.com)
Browsing SEARO Publications by Subject Antimicrobial Cationic Peptides
Browsing SEARO Publications by Subject "Antimicrobial Cationic Peptides" (apps.who.int)
Browsing Science (Faculty of) by Subject Proteins
Browsing Science (Faculty of) by Subject "Proteins" (uwspace.uwaterloo.ca)
Hansen, Jørn H | UiT
Hansen, Jørn H | UiT (uit.no)
Gillian Morrison - Fingerprint - University of Edinburgh Research Explorer
Gillian Morrison - Fingerprint - University of Edinburgh Research Explorer (research.ed.ac.uk)
IJMS | Free Full-Text | Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System...
IJMS | Free Full-Text | Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System... (mdpi.com)
KEGG COMPOUND: C20930
KEGG COMPOUND: C20930 (kegg.jp)
Profile | Biosciences | University of Exeter
Profile | Biosciences | University of Exeter (biosciences.exeter.ac.uk)
British Library EThOS: Bioinformatics approaches to structure and function of antimicrobial peptides
British Library EThOS: Bioinformatics approaches to structure and function of antimicrobial peptides (ethos.bl.uk)
Molecular Dynamics and EPR spectroscopy on lipid bilayers: new approaches to study biological membranes - University of...
Molecular Dynamics and EPR spectroscopy on lipid bilayers: new approaches to study biological membranes - University of... (research-portal.uea.ac.uk)
JCI Insight - Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity
JCI Insight - Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity (insight.jci.org)
Publikationen | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Publikationen | Max-Planck-Institut für Kolloid- und Grenzflächenforschung (mpikg.mpg.de)
Towards Control of Streptococcus iniae - Volume 15, Number 12-December 2009 - Emerging Infectious Diseases journal - CDC
Towards Control of Streptococcus iniae - Volume 15, Number 12-December 2009 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs | Microbiome | Full...
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs | Microbiome | Full... (microbiomejournal.biomedcentral.com)
Emerging antibacterial strategies with combined treatment | IJN
Emerging antibacterial strategies with combined treatment | IJN (dovepress.com)
Natural Antimicrobial Compounds in Small Intestinal Bacterial Overgrowth Syndrome | Natural Medicine Journal
Natural Antimicrobial Compounds in Small Intestinal Bacterial Overgrowth Syndrome | Natural Medicine Journal (naturalmedicinejournal.com)
Recombinant Human BD-3
Recombinant Human BD-3 (peprotech.com)
RCSB PDB - 4U9C: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS
RCSB PDB - 4U9C: STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS (rcsb.org)