Antilymphocyte Serum
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Anemia, Aplastic
Transplantation Immunology
Chromium Isotopes
Iodine Isotopes
Diaper Rash
Skin Transplantation
Skin
Graft Rejection
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Graft Survival
Immunoglobulins, Intravenous
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Plasmapheresis
Tissue Donors
Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Phlebography
Cord Blood Stem Cell Transplantation
Cell Differentiation
Tacrolimus
Logical Observation Identifiers Names and Codes
A vocabulary database of universal identifiers for laboratory and clinical test results. Its purpose is to facilitate the exchange and pooling of results for clinical care, outcomes management, and research. It is produced by the Regenstrief Institute. (LOINC and RELMA [Internet]. Indianapolis: The Regenstrief Institute; c1995-2001 [cited 2002 Apr 2]. Available from http://www.regenstrief.org/loinc)
Bone Marrow Transplantation
Stroke Volume
Ventricular Function, Left
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Transplantation, Homologous
Aluminum Oxide
Silanes
Transplantation Chimera
Bahamas
A chain of islands, cays, and reefs in the West Indies, lying southeast of Florida and north of Cuba. It is an independent state, called also the Commonwealth of the Bahamas or the Bahama Islands. The name likely represents the local name Guanahani, itself of uncertain origin. (From Webster's New Geographical Dictionary, 1988, p106 & Room, Brewer's Dictionary of Names, 1992, p45)
Hawks
Webcasts as Topic
Azathioprine
Coronary Artery Disease
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Encephalomyelitis, Autoimmune, Experimental
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Encephalomyelitis
Myelin Basic Protein
Internal Medicine
Freund's Adjuvant
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
Encephalomyelitis, Acute Disseminated
An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
Immunological control of a murine gammaherpesvirus independent of CD8+ T cells. (1/1079)
Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus. (+info)Long-term results of pancreas transplantation under tacrolius immunosuppression. (2/1079)
BACKGROUND: The long-term safety and efficacy of tacrolimus in pancreas transplantation has not yet been demonstrated. The observation of prolonged pancreatic graft function under tacrolimus would indicate that any potential islet toxicity is short-lived and clinically insignificant. We report herein the results of pancreas transplantation in patients receiving primary tacrolimus immunosuppression for a minimum of 2 years. METHODS: From July 4, 1994 until April 18, 1996, 60 patients received either simultaneous pancreas-kidney transplant (n=55), pancreas transplant only (n=4), or pancreas after kidney transplantation (n=1). Baseline immunosuppression consisted of tacrolimus and steroids without antilymphocyte induction. Azathioprine was used as a third agent in 51 patients and mycophenolate mofetil in 9. Rejection episodes within the first 6 months occurred in 48 (80%) patients and were treated with high-dose corticosteroids. Antilymphocyte antibody was required in eight (13%) patients with steroid-resistant rejection. RESULTS: With a mean follow-up of 35.1+/-5.9 months (range: 24.3-45.7 months), 6-month and 1-, 2-, and 33-year graft survival is 88%, 82%, 80%, and 80% (pancreas) and 98%, 96%, 93%, and 91% (kidney), respectively. Six-month and 1-, 2-, and 3-year patient survival is 100%, 98%, 98%, and 96.5%. Mean fasting glucose is 91.6+/-13.8 mg/dl, and mean glycosylated hemoglobin is 5.1+/-0.7% (normal range: 4.3-6.1%). Mean tacrolimus dose is 6.5+/-2.6 mg/day and mean prednisone dose 2.0+/-2.9 mg/day at follow-up. Complete steroid withdrawal was possible in 31 (65%) of the 48 patients with functioning pancreases. CONCLUSIONS: These data show for the first time that tacrolimus is a safe and effective long-term primary agent in pancreas transplantation and provides excellent long-term islet function without evidence of toxicity while permitting steroid withdrawal in the majority of patients. (+info)Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party. (3/1079)
We report the results of the first prospective randomized multicenter study of immunosuppressive treatment in patients with previously untreated nonsevere aplastic anemia (AA) as defined by a neutrophil count of at least 0.5 x 10(9)/L and transfusion dependence. Patients were randomized to receive cyclosporin (CSA) alone or the combination of horse antithymocyte globulin ([ATG] Lymphoglobuline; Merieux, Lyon, France) and CSA. The endpoint of the study was the hematologic response at 6 months. One hundred fifteen patients were randomized and assessable with a median follow-up period of 36 months; 61 received CSA and 54 ATG and CSA. In the CSA group, the percentage of complete and partial responders was 23% and 23%, respectively, for an overall response rate of 46%. A significantly higher overall response rate of 74% was found in the ATG and CSA group, with 57% complete and 17% partial responders (P =. 02). Compared with CSA alone, the combination of ATG and CSA resulted in a significantly higher median hemoglobin level and platelet count at 6 months. Fewer patients required a second course of treatment before 6 months due to a nonresponse. In the CSA group, 15 of 61 (25%) patients required a course of ATG before 6 months because of disease progression, compared with only 3 of 54 (6%) in the ATG and CSA group. The survival probabilities for the two groups were comparable, 93% (CSA group) and 91% (ATG and CSA group), but at 180 days, the prevalence of patients surviving free of transfusions, which excluded patients requiring second treatment because of nonresponse, death, disease progression, or relapse, was 67% in the CSA group and 90% in the ATG and CSA group (P =.001). We conclude that the combination of ATG and CSA is superior to CSA alone in terms of the hematologic response, the quality of response, and early mortality, and a second course of immunosuppression is less frequently required. (+info)Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. (4/1079)
To determine whether the antigen-driven T-cell response is involved in the pathogenesis of aplastic anemia (AA), we examined the complementarity-determining region 3 (CDR3) size distribution of T-cell receptor (TCR) beta-chain (BV) subfamilies in the bone marrow (BM) of untreated AA patients. AA patients who did not respond to immunosuppressive therapy and those who obtained unmaintained remission early after cyclosporine (CyA) or antithymocyte globulin (ATG) therapy exhibited essentially a normal CDR3 size pattern. In contrast, five patients who needed continuous administration of CyA to maintain remission exhibited a skewed CDR3 size pattern in a number (>40%) of BV subfamilies suggestive of clonal predominance. The skewing of CDR3 size distribution became less pronounced in one of the CyA-dependent patients when the patient achieved unmaintained remission after a 4-year therapy with CyA, whereas it persisted longer than 7 years in the other patient requiring maintenance therapy. Sequencing of BV15 cDNA for which the CDR3 size pattern exhibited apparent clonal predominance in all CyA-dependent patients showed high homology of the amino acid sequence of the CDR3 between two different patients. These findings indicate that antigen-driven expansion of T cells is involved in the pathogenesis of AA characterized by CyA-dependent recovery of hematopoiesis. (+info)Late graft failure 8 years after first bone marrow transplantation for severe acquired aplastic anemia. (5/1079)
A 14-year-old patient with acquired very severe aplastic anemia (VSAA) underwent bone marrow transplantation (BMT) from his HLA-identical brother. Preparative therapy was cyclophosphamide (CY) 200 mg/kg over 4 days. GVHD prophylaxis was with cyclosporin A (CsA) for a year. After an 8 year follow-up during which the patient was well with normal blood counts, graft failure occurred. At this time marrow chimerism studies demonstrated that 85% of hemopoiesis was of recipient origin. The patient was re-engrafted from the same donor after conditioning with CY 200 mg/kg over 4 days plus rabbit antithymocyte globulin (ATG) 3.5 mg/kg/day for 3 days. After 140 days follow-up he has a normal blood count. The possible causes of the graft failure are discussed. This case demonstrates that, although rarely, very late graft failure may occur after BMT for AA and highlights the need for long-term monitoring even in apparently successfully transplanted patients. (+info)Monitoring anti-thymocyte globulin (ATG) in bone marrow recipients. (6/1079)
The present study was undertaken to acquire a rationale for clinical dose adjustment of anti-thymocyte globulin (ATG) to improve cost effectiveness and safety of graft-versus-host disease prophylaxis. The concentration of rabbit ATG in the serum of 12 patients was measured by ELISA and by the inhibitory effect on phytohaemagglutinin-induced blastogenesis. At 10 mg/ml ATG, 3H-thymidine incorporation was effectively blocked. Serial two-fold dilution of ATG showed that this effect decreased in a concentration-dependent manner and was lost at 10 ng/ml ATG. One hundred microlitres serum taken at day -1 to +22 post transplant effected significant inhibition of the phytohaemagglutinin-response with 49+/-12% c.p.m. (x +/- s.d.) on day +1 post transplant compared to 93+/-13% c.p.m. on day -1 (P<0.001, unpaired one-sided t-test). The rabbit-IgG was maximal at a concentration of 907+/-187 microl/ml at day 0. Subsequently, it decreased with time. While rabbit-IgG was detectable for a long period (e.g. 160 microg/ml at day +22 in patient MD), the effect on the phytohaemagglutinin-response of normal mononuclear cells lasted up to 4 days post transplant. We conclude that 90 mg/kg body weight ATG-Fresenius given prior to marrow transplant leads to sustained T cell immunosuppression post transplant. (+info)Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow. (7/1079)
A five-agent GVHD prophylaxis programme consisting of cyclosporin A, methotrexate, anti-thymocyte-globulin, pentaglobin and metronidazol was given to 48 recipients of unrelated donor marrow with chronic myelogenous leukemia, acute leukemia, myelodysplastic syndromes, and familiar lymphocytic hemophagocytosis of an average age of 33.5 (0.6-56) years. GVHD grades II-IV occurred in 18 patients (39%) and grades III-IV in five patients (11%). Chronic GVHD developed in nine patients (23%), three limited and six extensive. Fifteen patients died. Clinical relapse was detected in eight patients. Four patients died as a consequence of the underlying disease and subsequent treatment, 11 patients died of transplant-related causes. After a median follow-up of 19 months, the overall and disease-free survival are 67% and 62%, respectively. Survival by age is as follows: 0-19 years: 12/13 patients; 20-39 years: 14/25 patients; 40-59 years: 7/10 patients. The five-agent GVHD prophylaxis regimen is effective. Matched-unrelated donor transplants can be carried out safely in patients younger than 50 years of age. The results in patients younger than 20 years of age should encourage matched-unrelated donor transplants at earlier stages of the disease. (+info)L-Arginine supplementation increases mesangial cell injury and subsequent tissue fibrosis in experimental glomerulonephritis. (8/1079)
BACKGROUND: Mesangial cell lysis in the antithymocyte serum (ATS)-induced model of glomerulonephritis is dependent on the generation of cytotoxic nitric oxide (NO) through transient induction of NO synthase (iNOS). We hypothesized that increased availability of L-arginine (L-Arg) during mesangial cell lysis might provide iNOS with increased substrate leading to increased lysis, and that this increased lysis would be reflected in more severe fibrotic disease at day 6. METHODS: To ensure whole body equilibration with high L-Arg at the time of injury, rats were pretreated with 1% L-Arg in drinking water for one week prior to the administration of ATS. Animals were sacrificed six hours after ATS injection when previous experiments had indicated iNOS induction had occurred and at six days. At six hours, plasma was obtained for L-Arg levels and nitrite/nitrate (NOx) content. Renal tissues were taken for histological evaluation of glomerular cell counts, macrophage infiltration (ED-1), and iNOS expression. Glomeruli were isolated for detection of iNOS mRNA and placed in culture to study the dependence of NO production on L-Arg concentration. In rats sacrificed at six days, L-Arg supplementation was stopped 16 hours after ATS injection. Fibrotic disease was evaluated by urinary protein excretion, histological assessment of glomerular cell number, matrix accumulation, and production of transforming growth factor-beta1 and matrix components fibronectin and plasminogen activator inhibitor type-1 (PAI-1) by isolated glomeruli in culture. RESULTS: At six hours, the glomerular cell number was significantly reduced by ATS injection (P < 0.01) and further significantly (P < 0. 05) reduced by L-Arg feeding [normal control (NC) = 64.2 +/- 1, ATS = 53.4 +/- 0.7, ATS + L-Arg = 50.8 +/- 0.7]. Disease increased macrophage infiltration and iNOS protein and iNOS mRNA levels markedly (P < 0.01), whereas L-Arg feeding did not further increase these variables. Plasma L-Arg levels (nmol/ml) were reduced by disease (NC = 121 +/- 9, ATS = 84 +/- 13, P < 0.01) and elevated by L-Arg feeding (ATS + L-Arg = 166 +/- 12, P < 0.01). Plasma NOx was significantly increased by ATS and further increased by ATS + L-Arg (P < 0.05). Production of NOx by cultured glomeruli showed striking L-Arg concentration dependence in six hours but not in normal glomeruli. In the group sacrificed at day 6, day 2 proteinuria was higher in the ATS + L-Arg group compared with the ATS alone group (P < 0.05). Measures of fibrotic disease at day 6 all showed large increases over control with ATS alone (P < 0.01), and further small, but significant increases when L-Arg was combined with ATS (P < 0.05). CONCLUSIONS: The results indicate that if given during disease induction, L-Arg supplementation can enhance iNOS-dependent tissue injury by providing increased substrate. Although the increase in injury with L-Arg supplementation was small, it led to increased fibrosis at day 6. These data predict that in diseases with repeated iNOS-dependent tissue injury, L-Arg supplementation may produce cumulative increases in tissue fibrosis. (+info)
DDrare: Database of Drug Development for Rare Diseases
Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and...
Anti-lymphocyte globulin - Wikipedia
Antithymocyte globulin financial definition of antithymocyte globulin
Anti-thymocyte globulin
Thymoglobulin Induction in Kidney Transplant Recipients - Full Text View - ClinicalTrials.gov
Impact of antithymocyte globulin on the need for platelet transfusions during reduced-intensity conditioning administration...
Effect of antilymphocytic and antithymocytic sera on the development o by D L. Vredevoe and E F. Hays
Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem...
Regression of a T-Cell Lymphoma after Administration of Antithymocyte Globulin | Annals of Internal Medicine | American College...
Update on the randomized trial of post-transplanation cyclophosphamide and rabbit ATG for graft-versus-host disease prophylaxis...
Randomized, Prospective Single-center Study Comparing a Rapid Discontinuation of Corticosteroids (Steroid Withdrawal) With...
Review Information for Modest dose anti-thymocyte globulin administered intraoperatively is safe and effective in kidney...
Anti-Thymocyte Globulin (Rabbit) Dosage Guide with Precautions - Drugs.com
Anti-thymocyte globulin (equine) Information - Drugs.com
Cardiac Pathology: Heart: Ischaemic heart disease | Podcasts | Naked Scientists
Inactication of thymus and marrow-derived lymphocytes by heterologous by H Jeejeebhoy
RePub, Erasmus University Repository:
T cells Exhibit Reduced Signal Transducer and Activator of Transcription 5...
Plus it
GMS | 130. Kongress der Deutschen Gesellschaft für Chirurgie | ATG modulates the endothelial activity and immune cell adhesion
Publications - Mayo Clinic
A Retrospective, single center study comparing outcomes of patients who did and did not recieve antithymocyte globulin for...
Antithymocyte Globulin (Equine) Overview | FoundHealth
Fludarabine, Busulfan, and Antilymphocyte Globulin Followed by Donor Stem Cell Transplant in Treating Older Patients With...
An attempt at isolation and partial characterization of specific antibodies from antithymocyte serum | Meta
The immunologic advantage of HIV-exposed seronegative indi... : AIDS
Donor Stem Cell Transplant After Busulfan, Fludarabine, and Antithymocyte Globulin in Treating Patients With Hematological...
Profound lymphopenia is associated with a lower risk of hepatic cytolysis during antithymocyte globulin administration. | CEpiA...
The role of blocking factors and antipaternal lymphocytotoxic antibodies in the success of pregnancy in patients with recurrent...
Is there a way to test your personal COVID vaccine response? How do corticosteroids impact response? - LessWrong 2.0 viewer
Thymoglobulin - Blink Price $23,644.91 | Blink Health
Ossential® Growth Factor Serum Plus | Shop ZO®
Interanimate: January 2008
Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia<...
Antithymocyte globulin | definition of antithymocyte globulin by Medical dictionary
Basiliximab vs Thymoglobulin: Who wins in Induction Immunosuppressive Therapy after Kidney Transplantation?
Antithymocyte Globulin for Matched Sibling Donor Transplantation in Patients With Hematologic Malignancies: A Multicenter, Open...
A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG),...
Antithymocyte Globulin for Treatment of the Bone Marrow Failure Associated with Myelodysplastic Syndromes | Annals of Internal...
Phillip Scheinberg.
Immunosuppressive Therapy-Induced Hepatotoxicity in Patients with Aplastic Anemia [Turk J Hematol]
The cost-effectiveness of induction immunosuppression in kidney transplantation<...
Fludarabine, cyclophosphamide, and antithymocyte globulin for a patient with dyskeratosis congenita and severe bone marrow...
Early hemopoietic progenitors in the peripheral blood of patients with severe aplastic anemia (SAA) after treatment with...
Most recent papers with the keyword Bk virus | Read by QxMD
Infection after heart transplantation: A multiinstitutional study
The spontaneous and induced synthesis of Epstein-Barr virus antigens in Raji cells immobilized on surface coated with anti...
NFkB p65 Rabbit anti-Human, Mouse, Rat, Polyclonal, eBioscience™ 50 μg; Unconjugated NFkB p65 Rabbit anti-Human, Mouse, Rat,...
Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation.
Extended Dosing With Eltrombopag for Severe Aplastic Anemia | Aplastic Anemia and MDS International Foundation
ERBB2 Rabbit anti-Human, Unconjugated, Clone: BCI-5, Abnova 100 μg;
| Fisher Scientific
Clinical Trial | Alemtuzumab to Treat Severe Aplastic Anemia
Severe Aplastic Anemia and PNH | SpringerLink
Severe Aplastic Anemia: What Is It & Treatment Options | Americord Topic Center
Real-Politik Ditto: Did science really cure the first case of HIV (aka AIDS...
ATG10 Rabbit anti-Human, Polyclonal, Invitrogen 100 µL; Unconjugated
| Fisher Scientific
Immunosuppressive drug
Later during the treatment, some patients develop serum sickness or immune complex glomerulonephritis. Serum sickness arises ... The antilymphocyte (ALG) and antithymocyte antigens (ATG) are being used. They are part of the steroid-resistant acute ... Heterologous polyclonal antibodies are obtained from the serum of animals (e.g., rabbit, horse), and injected with the ... As of March 2005, there are two preparations available to the market: Atgam, obtained from horse serum, and Thymoglobuline, ...
Jean-François Bach
... antilymphocyte sera, monoclonal antibodies against Tlymphocytes). He has been interested in the mechanisms and treatments of ...
Włodzimierz Ptak
"Improved graft survival after treatment with Bordetella and anti-lymphocyte serum". Nature. 222 (5198): 1083-5. Bibcode: ... Ptak W, Porwit-Bóbr Z, Chlap Z (1970). "Transformation of hamster macrophages into giant cells with antimacrophage serum". ...
Medical Research Club
Peter Medawar gave a lecture entitled "Anti-lymphocyte serum" in May 1967; Henry Harris discussed "The expression of genetic ...
Michael Woodruff
Among these contributions, Woodruff's work with anti-lymphocyte serum has led to its wide use to reduce rejection symptoms in ... Woodruff also commenced work on antilymphocyte serum for immunosuppression, with little initial success. While in Aberdeen, ...
Anti-lymphocyte globulin
... (ALG) is an infusion of animal- antibodies against human T cells which is used in the treatment of ... The product was manufactured by Upjohn and Merieux, as well as the Schweizerisches Serum- und Impfinstitut in Bern, the latter ... "Guillain Barré syndrome precipitated by the use of antilymphocyte globulin in the treatment of severe aplastic anaemia". J. ... Treatment of aplastic anaemia by antilymphocyte glubulin with and without allogeneic bone marrow infusions, in Lancet (1977) 2: ...
Thymoglobulin
Since the discovery of a link between antilymphocyte serum (ALS) and lymphocyte depletion by Metchnikoff in 1899, various ... Antithymocyte globulin (ATG) was originally developed as one of various tested preparations of antilymphocyte globulin (ALG) ... leading to testing of ATG derived from rabbit serum. Thymoglobulin was the first commercial rabbit-derived ATG to be introduced ...
List of MeSH codes (D12.776)
... immune sera MeSH D12.776.377.715.548.114.573.203 - antilymphocyte serum MeSH D12.776.377.715.548.114.580 - immunoconjugates ...
List of MeSH codes (D12.776.124)
... immune sera MeSH D12.776.124.486.485.114.573.203 - antilymphocyte serum MeSH D12.776.124.486.485.114.573.601 - antitoxins MeSH ... immune sera MeSH D12.776.124.790.651.114.573.203 - antilymphocyte serum MeSH D12.776.124.790.651.114.580 - immunoconjugates ...
List of MeSH codes (A12)
... serum MeSH A12.207.152.846.500 - immune sera MeSH A12.207.152.846.500.203 - antilymphocyte serum MeSH A12.207.180 - body fluid ...
List of MeSH codes (D20)
... immune sera MeSH D20.215.401.203 - antilymphocyte serum MeSH D20.215.535 - menotropins MeSH D20.215.659 - picibanil MeSH ...
Anti-thymocyte globulin
When he subsequently collected serum from these Guinea pigs and injected it into normal mice he observed a marked depletion in ... A similar trial of anti-lymphocyte globulin showed a trend in reduction of aGVH that was not statistically significant, but a ...
Intestine transplantation
Additionally, blood serum should be tested for the presence of viruses, including HIV, hepatitis B and C, cytomegalovirus (CMV ... They may also be treated with anti-lymphocyte antibodies (anti-thymocyte globulin, alemtuzumab), irradiation directed against ... and serum pH and lactate levels measured for evidence of intestinal ischemia. The patient's immune system is strongly modulated ...
Aplastic anemia
Negative sera from patients with other autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis and multiple ... First-line treatment for aplastic anaemia consists of immunosuppressive drugs, typically either anti-lymphocyte globulin or ... Corticosteroids are generally ineffective, though they are used to ameliorate serum sickness caused by ATG. Normally, success ... revealed more than 30 potential specific candidate autoantigens after serologic screening of a fetal liver library with sera ...
Ustekinumab
Serum target. (noncellular). *Complement component 5 *Eculizumab. *TNF *Adalimumab. *Afelimomab. *Certolizumab pegol ...
Infliximab
It has a serum half-life of 9.5 days and can be detected in serum 8 weeks after infusion treatment.[25] ...
mTOR inhibitors
Serum target. (noncellular). *Complement component 5 *Eculizumab. *TNF *Adalimumab. *Afelimomab. *Certolizumab pegol ...
Transplant rejection
Anti-lymphocyte globulin (ALG). *Monoclonal anti-CD20 antibodies *Rituximab. Blood transfer[edit]. Cases refractory to ...
Pexelizumab
Serum target. (noncellular). *Complement component 5 *Eculizumab. *TNF *Adalimumab. *Afelimomab. *Certolizumab pegol ...
Immunomodulation with intrathymic grafts or anti-lymphocyte serum promotes long-term intraspinal allograft survival<...
Wistar rats thus first received FSC(SD) tissue as intrathymic grafts coupled with single-dose, anti- lymphocyte serum (ALS) ... Theele, D. P. ; Reier, P. J. / Immunomodulation with intrathymic grafts or anti-lymphocyte serum promotes long-term intraspinal ... Wistar rats thus first received FSC(SD) tissue as intrathymic grafts coupled with single-dose, anti- lymphocyte serum (ALS) ... Wistar rats thus first received FSC(SD) tissue as intrathymic grafts coupled with single-dose, anti- lymphocyte serum (ALS) ...
Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and their inhibitory effect on skin graft...
Fekete B, Petrányi G, Szegedi G, Szabó G. Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and ... T1 - Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and their inhibitory effect on skin graft ... Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and their inhibitory effect on skin graft ... Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and their inhibitory effect on skin graft ...
Reduction in the severity of Mycoplasma pneumoniae-induced pneumonia in hamsters by immunosuppressive treatment with...
Induction Therapy Study in Live Donor Kidney Transplant Recipients With a Positive Crossmatch - Full Text View - ClinicalTrials...
Antilymphocyte Serum. Daclizumab. Immunoglobulin G. Anti-Inflammatory Agents. Antiemetics. Autonomic Agents. Peripheral Nervous ... To achieve serum level of 8-10 ng/ml.. Drug: Dexamethasone 100 mg intra-operatively, and 25 mg every 6h post-operatively for ... To achieve serum level of 8-10 ng/ml.. Drug: Dexamethasone 100 mg intra-operatively, and 25 mg every 6h post-operatively for ...
Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease - Full Text View -...
Antilymphocyte Serum. Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. Calcineurin Inhibitors. ... Quantification of serum and urine M protein and serum free light chain analyses for patients with myeloma (Days 35, 70, 100, ... Contraindication to therapy with any one of the proposed agents (e.g., history of allergy to horse serum in ATG). ...
Cord Blood Expansion on Mesenchymal Stem Cells - Full Text View - ClinicalTrials.gov
Fludarabine-Based Conditioning for Allogeneic Marrow Transplantation in Aplastic Anemia - Full Text View - ClinicalTrials.gov
Antilymphocyte Serum. Fludarabine. Vidarabine. Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. ... serum total bilirubin , 2x upper limit of normal for age as per local laboratory; ALT and AST , 4x upper limit of normal for ... age as per local laboratory; c) renal: serum creatinine , 2x upper limit of normal for age (as per local laboratory). d) ...
JCI -
Regeneration of the pancreatic β cell
Ogawa, N, List, JF, Habener, JF, Maki, T. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum ... In a study by Ogawa et al., the treatment of overtly diabetic NOD mice with anti-lymphocyte serum (ALS) abrogated autoimmunity ... Nonstandard abbreviations used: ALS, anti-lymphocyte serum; BMP4, bone morphogenetic protein 4; GIP, glucose-dependent ... Seabergs PMP-derived cells were grown instead in the serum-free medium conditions normally used for neural stem cell culture ( ...
Donor and recipient pretransplant conditioning with nonlethal radiation and antilymphocyte serum improves the graft survival in...
Donor and recipient pretransplant conditioning with nonlethal radiation and antilymphocyte serum improves the graft survival in ... Donor and recipient pretransplant conditioning with nonlethal radiation and antilymphocyte serum improves the graft survival in ... Donor and recipient pretransplant conditioning with nonlethal radiation and antilymphocyte serum improves the graft survival in ... title = "Donor and recipient pretransplant conditioning with nonlethal radiation and antilymphocyte serum improves the graft ...
Suppression of microfilaricidal activity of diethylcarbamazine by anti-lymphocyte serum in cotton rat filariasis. | Southeast...
Suppression of microfilaricidal activity of diethylcarbamazine by anti-lymphocyte serum in Suppression of microfilaricidal ... Antilymphocyte Serum Language: English Journal: Southeast Asian J Trop Med Public Health Year: 1977 Type: Article ... Animals , Antilymphocyte Serum/pharmacology , Diethylcarbamazine/antagonists & inhibitors , Filariasis/drug therapy , ...
A prospective, pilot study of early corticosteroid cessation in high-immunologic-risk patients: the Cincinnati experience
Preliminary results of immunosuppression with thymoglobuline pretreatment and hepatitis C virus recurrence in liver...
HIV Test for Everyone? | MetaFilter
Lipemic serum (blood with high levels of fat or lipids. * Haemolyzed serum (blood where haemoglobin is separated from the red ... Anti-lymphocyte antibodies * Anti-collagen antibodies (found in gay men haemophiliacs Africans of both sexes and people with ... Serum-positive for rheumatoid factor antinuclear antibody (both found in rheumatoid arthritis and other autoantibodies * ...
Effect of length of gestation on maternal cellular immunity to human trophoblast antigens.
Antilymphocyte globulin | definition of antilymphocyte globulin by Medical dictionary
What is antilymphocyte globulin? Meaning of antilymphocyte globulin medical term. What does antilymphocyte globulin mean? ... Looking for online definition of antilymphocyte globulin in the Medical Dictionary? antilymphocyte globulin explanation free. ... antilymphocyte globulin (ALG) the gamma globulin fraction of antilymphocyte serum; used as an immunosuppressant in organ ... antilymphocyte globulin. Antilymphocyte serum Clinical immunology A polyclonal antiserum raised in one species of animals ...
Patent US6039684 - Non-lethal conditioning methods for the treatment of acquired ... - Google Patents
Immunologic Tolerance and Chimerism Produced Across the H-2 Locus with Adult Thymectomy and Anti-Lymphocyte Serum", Ann. NY ... Immunologic Tolerance and Chimerism Produced Across the H 2 Locus with Adult Thymectomy and Anti Lymphocyte Serum , Ann. NY ... Monaco et al., 1966, "Studies on Heterologous Anti-lymphocyte Serum in Mice. III. ... Monaco et al., 1966, Studies on Heterologous Anti lymphocyte Serum in Mice. III. ...
MEDLINE - Resultado p gina 1
All out | definition of all out by Medical dictionary
July 1973 - Volume 52 - Issue 1 : Plastic and Reconstructive Surgery
Cardiac Pathology: Heart: Ischaemic heart disease | Podcasts | Naked Scientists
Prophylactic Use of Rabbit Antihuman Thymocyte Immunoglobulin in Renal Transplantation
Aplastic Anemia Differential Diagnoses
Re-treatment of aplastic anemia with antithymocyte globulin or antilymphocyte serum. Am J Med. 1988 Apr. 84(4):678-82. [Medline ... Treatment of aplastic anemia with an investigational antilymphocyte serum prepared in rabbits. Am J Med Sci. 1994 Dec. 308(6): ... Liu H, Mihara K, Kimura A, Tanaka K, Kamada N. Induction of apoptosis in CD34+ cells by sera from patients with aplastic anemia ... Survival after antilymphocyte globulin therapy for aplastic anemia depends on disease severity. Blood. 1987 Oct. 70(4):1046-52 ...
CD4+CD25+ and CD4+CD25− T Cells Act Respectively as Inducer and Effector T Suppressor Cells in Superantigen-Induced Tolerance |...
An in Vitro Test of Cellular Immunity in Allergic Encephalomyelitis. | Annals of Internal Medicine | American College of...
Jean-François Bach - Wikipedia
Włodzimierz Ptak - Wikipedia
Kedrion products
The spontaneous and induced synthesis of Epstein-Barr virus antigens in Raji cells immobilized on surface coated with anti...
Antilymphocyte Serum/pharmacology. MESH. Cells, Cultured. MESH. Herpesvirus 4, Human/immunology. MESH. ... Immobilization of Raji cells on surface coated with anti-lymphocyte globulin (ALG) at low cell densities lead to the synthesis ... Immobilization of Raji cells on surface coated with anti-lymphocyte globulin (ALG) at low cell densities lead to the synthesis ... The spontaneous and induced synthesis of Epstein-Barr virus antigens in Raji cells immobilized on surface coated with anti-lymphocyte ...
The Allograft Defines the Type of Rejection (Acute versus Chronic) in the Face of an Established Effector Immune Response | The...
Identification of Regulatory T Cells in Tolerated Allografts | JEM
Globulin12
- Examples are transferrin, a beta 1 -globulin that transports iron, and alpha 1 -antitrypsin, an acute phase reactant that inhibits serum proteases. (thefreedictionary.com)
- immune human serum globulin immune globulin (def. (thefreedictionary.com)
- immune serum globulin immune g. (def. (thefreedictionary.com)
- Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. (medscape.com)
- According to a report on Chinese news website Sina.com , shortly after Lexuan was diagnosed with aplastic anaemia three years ago, doctors were able to stablise her condition using Antilymphocyte Globulin, which is serum from blood that contains anti-bodies that bind to human T cells. (dailymail.co.uk)
- Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure. (mdedge.com)
- Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review. (mdedge.com)
- Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. (mdedge.com)
- Tatum AH, Bollinger RR, Sanfilippo F. Rapid serologic diagnosis of serum sickness from antithymocyte globulin therapy using enzyme immunoassay. (mdedge.com)
- Cutaneous manifestations of serum sickness in patients receiving antithymocyte globulin. (mdedge.com)
- Animal serum was formerly used for passive immunization against some infectious diseases but now has very limited use in antitoxins, monoclonal antibodies, and antilymphocyte globulin. (tabers.com)
- Specific antibody-blocking activities in antilymphocyte globulin as correlates of efficacy for the treatment of aplastic anemia. (semanticscholar.org)
Anti-lymphocyte9
- Wistar rats thus first received FSC(SD) tissue as intrathymic grafts coupled with single-dose, anti- lymphocyte serum (ALS) ablation of the circulating host T-cell population. (elsevier.com)
- Theele, DP & Reier, PJ 1996, ' Immunomodulation with intrathymic grafts or anti-lymphocyte serum promotes long-term intraspinal allograft survival ', Cell Transplantation , vol. 5, no. 2, pp. 243-255. (elsevier.com)
- Suppression of microfilaricidal activity of diethylcarbamazine by anti-lymphocyte serum in cotton rat filariasis. (bvsalud.org)
- Monaco AP, Wood ML and Russel PS (1966) Studies on heterologous anti-lymphocyte serum in mice: III. (springer.com)
- Immunologic tolerance and chimerism produced across the H-2 locus with adult thymectomy and anti-lymphocyte serum. (springer.com)
- Anti-lymphocyte serum is not the only suspect-tumors have also occurred in patients treated with prednisone and Imuran alone. (indigo.ca)
- We investigated the susceptibility of ASCs and BM-MSCs to anti-lymphocyte serum (ALS) and tacrolimus. (uzh.ch)
- The fulminating disease, which occurs in adult mice after intracerebral inoculation with LCM virus, can be ameliorated by several treatments known to impair the immune response of the host, such as X-rays 6 , amethopterin 7 , thymectomy 8 and anti-lymphocyte serum 9 . (nature.com)
- Glathe, H et al, Evidence of Tumorigenic Activity of Candidate Cell Substrate in Vaccine Production by the Use of Anti-Lymphocyte Serum , Development Biol Std, 1977, 34:145-148. (bibliotecapleyades.net)
Monoclonal antibodies2
- the action of immunosuppressants (cyclosporin, antilymphocyte sera, monoclonal antibodies against Tlymphocytes). (wikipedia.org)
- And from there I went to antilymphocyte serum monoclonal antibodies, tolerance, xenotransplantation over the years, and here we are. (asts.org)
Transplantation4
- Herein, we evaluate the potential advantage of donor-specific bone marrow infusions in donor and or recipient preconditioned with total body irradiation and or antilymphocyte serum (ALS) on the incidence of GVHD and rejection after small bowel transplantation. (elsevier.com)
- Epstein-Barr virus [EBV] serostatus of the recipient and the cytomegalovirus [CMV] sero-status of the recipient and the potential donor) and the principal risk factor after transplantation (immunosuppression with antilymphocyte antibody), we analyzed the findings for the first 381 consecutive adult nonrenal transplant recipients seen at Mayo Clinic. (elsevier.com)
- Nowadays most immunosuppressive regimens used early after transplantation are based on CsA, usually combined with other pharmacological drugs and, in many instances, also with biological antilymphocyte agents. (uninet.edu)
- The author shows that the use of antilymphocyte serum (ALS), normally used following organ transplantation, is capable of inducing biological and clinical manifestations which are analogous to those of patients suffering from AIDS. (bireme.br)
Antibodies3
- False-positives occur when antilymphocyte antibodies are present. (labcorp.com)
- The induction agent has evolved over the years from Minnesota ALG, to monoclonal antilymphocyte antibodies OKT3 and thymoglobulin. (scirp.org)
- We found that patient sera with elevated levels of TRIM72 autoantibodies suppress sarcolemmal resealing in healthy skeletal muscle, and depletion of TRIM72 antibodies from these same serum samples rescues sarcolemmal repair capacity. (jci.org)
Graft Rejection1
- Connection between the anti-organ and anti-nuclear titres of antilymphocyte sera and their inhibitory effect on skin graft rejection in mice. (elsevier.com)
Immunosuppression1
- Immunosuppression was by Azathioprine, prednisolone and antilymphocyte serum. (thenakedscientists.com)
Depletion1
- Treatment with polyclonal antilymphocyte globulins induces depletion of circulating CD3+CD4+CD28− T-cells in transplant recipients.Prevalences of peripheral circulating CD3+CD4+CD28− T-cells in 16 age- and sex-matched healthy controls, 5 allograft recipients before and 6 hours after the application of ATG-F and 11 control patients before and 6 hours after organ transplantation. (nih.gov)
Globulins4
- The plasma globulins are separated into five fractions by serum protein electrophoresis (SPE). (thefreedictionary.com)
- Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells. (nih.gov)
- In this study we evaluated the influence of polyclonal antilymphocyte globulins (ATG-Fresenius, ATG-F) on CD4(+)CD28(-) T-cells in vivo and in vitro. (nih.gov)
- Antiproliferative effect of antilymphocyte globulins on B cells and B-cell lines. (semanticscholar.org)
Incidence1
- 07). The incidence of steroid-resistant rejection requiring antilymphocyte therapy (OKT3 or ATGAM) was 13%, and was not different between the double and triple therapy groups. (nih.gov)
Rejection4
- Serum sickness is a hypersensitivity reaction to proteins in antiserum derived from nonhuman animal sources and can be seen in patients being treated with antiserum to prevent transplant rejection. (mdedge.com)
- We present a case of a 35-year-old man with presumed serum sickness after receiving thymoglobulin for the treatment of acute cellular rejection of a heart transplant. (mdedge.com)
- Serum sickness can be seen in patients treated with thymoglobulin to prevent transplant rejection. (mdedge.com)
- Acute rejection in human renal allografts is manifested as an increase in serum creatinine levels associated with typical biopsy findings. (asnjournals.org)
Antilymphocytic serum1
- 1976) Possible active enhancement of a human cadaver renal allograft with antilymphocytic serum (ALS) and donor bone marrow: Case report of an initial attempt. (springer.com)
Immunologic1
- A prospective clinical and immunologic analysis of patients with serum sickness. (mdedge.com)
Aplastic anemia1
- Liu H, Mihara K, Kimura A, Tanaka K, Kamada N. Induction of apoptosis in CD34+ cells by sera from patients with aplastic anemia. (medscape.com)
Cyclosporine1
- Initiation of cyclosporine treatment post-transplant was delayed until the serum creatinine was ≤2.5 mg/dl. (scirp.org)
Antibody1
- The increase in serum creatinine levels, caused by a decrease in the GFR, often responds to pulse steroid therapy or antilymphocyte antibody therapy. (asnjournals.org)
Allograft1
- 1986) Prolongation of renal allograft survival in antilymphocyte-serumtreated dogs by postoperative injection of density-gradientfractionated donor bone marrow. (springer.com)
Creatinine1
- The mean serum creatinine was 1.8 +/- 0.8 mg/dl. (nih.gov)
Cells1
- The serum, administered to humans with transplanted organs, in some way inactivates lymphocyte cells. (thefreedictionary.com)
Sickness7
- Serum sickness may display variable clinical presentations. (mdedge.com)
- Serum sickness can display multiple cutaneous manifestation, thus making it an important entity for dermatologists. (mdedge.com)
- Selection of treatment of cefaclor-associated urticarial, serum sickness-like reactions and erythema multiforme by emergency pediatricians: lack of a uniform standard of care. (mdedge.com)
- Severe serum sickness reaction to oral and intramuscular penicillin. (mdedge.com)
- Finger E, Scheinberg M. Development of serum sickness-like symptoms after rituximab infusion in two patients with severe hypergammaglobulinemia. (mdedge.com)
- Tatum AJ, Ditto AM, Patterson R. Severe serum sickness-like reaction to oral penicillin drugs: three case reports. (mdedge.com)
- Serum sickness can also occur after administration of penicillins and other drugs. (tabers.com)
Protein2
- We identified autoantibodies against TRIM72 (also known as MG53), a muscle-enriched membrane repair protein, in IIM patient sera and in our mouse model of IIM by ELISA. (jci.org)
- Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. (semanticscholar.org)
Occur1
- strabismus, nystagmus, and optic atrophy can also occur.etiologyperoxisomal acyl-coa oxidase deficiency is caused by mutations in the acox1 gene (17q25.1) encoding peroxisomal straight-chain acyl-coa oxidase.diagnostic methodsdiagnosis is based on laboratory studies revealing increased serum very-long chain fatty acids (vlcfa) and markedly reduced acyl-coa oxidase activity in fibroblasts. (malacards.org)
Human3
- For the measurement of C3d-bound circulating immune complexes (CIC) present in human plasma or serum. (labcorp.com)
- In another immunosuppressive method, human lymphocytes are injected into horses, stimulating the animals to produce antilymphocyte serum. (thefreedictionary.com)
- We hybridized 35 and 51 ICL patients' sera to a 9,000 human proteome array and to a 128 known autoantigens array, respectively. (jci.org)
Rabbit1
- Antithymocyte immunoglobulin from rabbit serum is classified in L04AA04. (whocc.no)
Effect1
- The Effect of Antilymphocyte Serum on Experimental Allergic Encephalomyelitis. (annals.org)
Treatment1
- Reduction in the severity of Mycoplasma pneumoniae-induced pneumonia in hamsters by immunosuppressive treatment with antithymocyte sera. (nih.gov)
Animals1
- Serum from ALS-treated animals was added to cell cultures. (uzh.ch)
Patients1
- Serum markers of cardiomyocyte injury (troponin, creatine kinase-myocardial band) are almost always elevated, and brain natriuretic peptide might be elevated in more than half of the cases (though it is chronically elevated in patients with cancer). (acc.org)