Blood Platelets
Platelet Aggregation
Platelet Adhesiveness
Platelet Membrane Glycoproteins
Antigens, Human Platelet
Platelet Factor 4
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Antigens, Neoplasm
Antigens, Surface
Adenosine Diphosphate
Platelet Activation
Platelet Glycoprotein GPIIb-IIIa Complex
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Platelet Transfusion
Platelet Activating Factor
Platelet Glycoprotein GPIb-IX Complex
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Platelet Function Tests
Thromboxane A2
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Prostaglandin Endoperoxides, Synthetic
Antigens, Protozoan
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
HLA Antigens
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Collagen
P-Selectin
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Receptors, Thromboxane
Receptors, Purinergic P2Y12
von Willebrand Factor
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Bleeding Time
Antigens, Helminth
Aspirin
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Prostaglandins H
Receptors, Thrombin
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Amino Acid Sequence
Thromboxanes
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
Platelet Membrane Glycoprotein IIb
Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Cell Membrane
Carcinoembryonic Antigen
Platelet Factor 3
Blood Proteins
Antigens, Viral, Tumor
Rabbits
Blood Coagulation Factors
Thrombasthenia
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
Phosphatidylinositols
HLA-DR Antigens
Blood Coagulation
Arachidonic Acid
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Immunoglobulin G
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Electrophoresis, Polyacrylamide Gel
Epoprostenol
Hemostasis
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Ristocetin
Receptors, Thromboxane A2, Prostaglandin H2
Crotalid Venoms
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Platelet Aggregation Inhibitors
Calcimycin
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Glycoproteins
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
Phosphorylation
Receptors, Prostaglandin
Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).
Receptors, Antigen, B-Cell
Prostate-Specific Antigen
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Antibodies
Cells, Cultured
Cross Reactions
Immunoglobulin Fab Fragments
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Antibody Specificity
Thrombopoiesis
Antigens, CD15
Immunoelectrophoresis, Two-Dimensional
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Immune Sera
Thrombospondins
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, Tumor-Associated, Carbohydrate
Apyrase
Membrane Proteins
HLA-A2 Antigen
Arachidonate 12-Lipoxygenase
Antigens, CD8
Peptide Fragments
Platelet Storage Pool Deficiency
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Reactions
Thromboxane B2
Type C Phospholipases
A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.
Receptor, PAR-1
Phosphatidic Acids
Thromboxane-A Synthase
Protein Binding
Edetic Acid
Blood Group Antigens
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Purpura, Thrombocytopenic
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Dose-Response Relationship, Drug
Hepatitis B Surface Antigens
Receptors, Collagen
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
Receptors, Purinergic P2Y1
Binding, Competitive
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Prostaglandin H2
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Integrin alpha2
Platelet-Rich Plasma
Thrombopoietin
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Enzyme Activation
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigen-Antibody Complex
Base Sequence
Antigens, Differentiation
Blood Preservation
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Cytosol
Adenosine Triphosphate
Receptors, Antigen
Hepatitis B Antigens
Blotting, Western
Prostaglandins D
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Indomethacin
Indium
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Prostaglandin Endoperoxides
Cytoskeleton
Chromatography, Affinity
Leukocytes
Antibody Formation
Cyclic AMP
Binding Sites
Antigens, CD1
Isoantibodies
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Cattle
Hirudins
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Dihydroergotoxine
A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.
Inositol Phosphates
Bernard-Soulier Syndrome
Immunodiffusion
Phospholipases A2
Adenylate Cyclase
Binding Sites, Antibody
Erythrocytes
Prostaglandins E
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Receptors, IgG
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Blood Cell Count
B-Lymphocytes
Oxyquinoline
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Cell Adhesion Molecules
Iloprost
An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Thrombotic thrombocytopenic purpura and autoimmunity: a tale of shadows and suspects. (1/157)
BACKGROUND AND OBJECTIVE: The key pathogenic feature of TTP is the formation of platelet aggregates within the microcirculation; however, the etiology of such aggregates has been elusive for years. A large amount of evidence points to an abnormal interaction between damaged vascular endothelium and platelets, although the cause of the primary microvascular endothelial cell injury is seldom clear. The autoimmune hypothesis often recurs, and this is based on a number of observations: the claimed superiority of plasma-exchange over plasma infusion, the anecdotal report of the presence of immunocomplexes and autoantibodies in TTP patients, the efficacy of the administration of corticosteroids and other immunosuppressant agents, and the concomitant occurrence of TTP in association with autoimmune diseases, especially systemic lupus erythematosus (SLE). This review will focus on the complex relationships between TTP and humoral autoimmunity; in particular, similarities and differences between TTP, SLE and antiphospholipid (aPL) antibodies syndrome, as well as the putative role of several other antibodies directed towards endothelial cells and/or platelets, including the recently discovered anti-CD36 antibodies and antivWF-cleaving metalloprotease, will be discussed. DESIGN AND METHODS: The authors have been involved in the study and treatment of TTP and autoimmune diseases for years; furthermore, the PubMed data base of the National Library of Congress has been extensively searched using the Internet. CONCLUSIONS: Although over the years evidence has increased in favor of the autoimmune hypothesis for TTP etiopathogenesis, TTP should not yet be considered an autoimmune disease. Autoantibodies should be regarded as only one of the many different insults which can trigger microvascular thrombosis even though the autoimmune theory of the pathogenesis of TTP is gaining more and more strength. As far as concerns the relationship between TTP, SLE and aPL antibodies-related disorders, these diseases should be distinguished on the basis of both different clinical presentations and accurate antibody screening, although this approach should definitely not delay the prompt start of treatment. (+info)Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. (2/157)
The platelet glycoprotein IIb/IIIa (GP IIb/IIIa) plays a pivotal role in platelet aggregation. Recent data suggest that the PlA2 polymorphism of GPIIIa may be associated with an increased risk for cardiovascular disease. However, it is unknown if there is any association between this polymorphism and platelet reactivity. We determined GP IIIa genotype and platelet reactivity phenotype data in 1422 subjects from the Framingham Offspring Study. Genotyping was performed using PCR-based restriction fragment length polymorphism analysis. Platelet aggregability was evaluated by the Born method. The threshold concentrations of epinephrine and ADP were determined. Allele frequencies of PlA1 and PlA2 were 0.84 and 0.16, respectively. The presence of 1 or 2 PlA2 alleles was associated with increased platelet aggregability as indicated by incrementally lower threshold concentrations for epinephrine and ADP. For epinephrine, the mean concentrations were 0.9 micromol/L (0.9 to 1.0) for homozygous PlA1, 0.7 mmol/L (0.7 to 0.9) for the heterozygous PlA1/PlA2, and 0.6 micromol/L (0.4 to 1.0) for homozygous PlA2 individuals, P=0.009. The increase in aggregability induced by epinephrine remained highly significant (P=0.007) after adjustment for covariates. For ADP-induced aggregation, the respective mean concentrations were 3.1 micromol/L (3.0 to 3.2), 3.0 micromol/L (2.9 to 3.2), and 2.8 micromol/L (2.4 to 3.3); P=0.19 after adjustment for covariates. Our findings indicate that molecular variants of the gene encoding GP IIIa play a role in platelet reactivity in vitro. Our observations are compatible with and provide an explanation for the reported association of the PlA2 allotype with increased risk for cardiovascular disease. (+info)Construction of a human platelet alloantigen-1a epitope(s) within murine glycoprotein IIIa: identification of residues critical to the conformation of the antibody binding site(s). (3/157)
The human platelet alloantigen 1 system (HPA-1) is determined by a polymorphism at position 33 in the N-terminus of human glycoprotein IIIa (GPIIIa). This naturally occurring substitution creates a conformation in the HPA-1a allelic form that can be antigenic when presented to an individual expressing the HPA-1b form. Anti-HPA-1a antibodies generated by this immune response can lead to the destruction of platelets, as seen in the clinical disorders, neonatal alloimmune thrombocytopenia (NAIT) and posttransfusion purpura (PTP). To understand better the structural requirements for recognition by these pathogenic antibodies, we investigated the N-terminal 66 amino acids from the HPA-1a form of human GPIIIa and the analogous amino acids from the nonimmunogenic murine homolog. Our objectives were to define further the boundaries of the HPA-1a epitope(s) in the N-terminus of human GPIIIa, to isolate the murine 5' nucleotide sequence and compare the deduced murine N-terminal sequence to that of human, and to mutate the murine sequence systematically to include an HPA-1a epitope(s). Murine amino acids that differed from human were changed by site-directed mutagenesis to the analogous residues in the HPA-1a form of human GPIIIa, starting and radiating from murine position 33 (site of human polymorphism). This systematic approach allowed us to pinpoint amino acids critical to a conformation recognized by anti-HPA-1a antibodies. Our results show that an HPA-1a epitope can be created within the N-terminus of murine GPIIIa and raise the possibility that murine models of HPA-1a sensitization can be developed. (+info)Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA-5b incompatibility. (4/157)
We report out experience in the perinatal management of a complex case of fetal hemolytic disease primarily due to Rhesus incompatibility combined with fetal alloimmune thrombocytopenia. The lowest fetal hemoglobin and platelet levels were 2.6 g/dl and 13,000/microliter, respectively. Intrauterine treatment consisted of six transfusions of packed red cells into the umbilical vein and one transfusion of platelets. The neonate required four transfusions of packed red cells to correct her hyporegenerative erythropoiesis. Postnatal management also included one platelet transfusion, intravenous immunoglobulins and erythropoietin. Although some degree of fetal thrombocytopenia may invariably be found in fetal red cell incompatibility, other rare causes need to be excluded. (+info)Association of the platelet glycoprotein IIb HPA-3 polymorphism with survival after acute ischemic stroke. (5/157)
BACKGROUND AND PURPOSE: The role of polymorphisms of the platelet glycoprotein (GP) IIb/IIIa receptor in the development of cardiovascular disease has been the subject of intensive research. The aim of this study was to determine the association of the HPA-3 polymorphism of platelet GPIIb with ischemic stroke and subsequent survival and to identify possible interactions of HPA-3 with classic risk factors. METHODS: HPA-3 genotype was determined by restriction fragment length polymorphism in 515 patients with ischemic stroke and 423 healthy, age-matched control subjects. RESULTS: There was no significant difference in the genotype distribution of patients and controls, nor was there any difference when patients were subclassified into small- and large-vessel disease. The genotype distribution of the 231 patients subsequently dying during 2.8 years of follow-up (aa=45.0%, ab=46.8%, bb=8.2%) was significantly different from that of those still alive (aa=37.0%, ab=48.2%, bb=14. 8%) (P=0.03). In a Cox regression model, the relative risks for poststroke mortality in patients of aa and ab genotype compared with those of bb genotype were 2.42 (95% CI, 1.24 to 4.71) and 2.13 (95% CI, 1.09 to 4.17), respectively, after we accounted for confounding factors. In addition, significant interactions of HPA-3 with the Pl(A) polymorphism of GPIIIa (P=0.002) and with fibrinogen (P=0.01) were identified in relation to mortality. CONCLUSIONS: HPA-3 is related to poststroke mortality, and the significant interaction of HPA-3 with Pl(A) and fibrinogen suggests that it may in some way influence the interaction of GPIIb/IIIa with fibrinogen, particularly in the presence of high fibrinogen. (+info)A point mutation Thr(799)Met on the alpha(2) integrin leads to the formation of new human platelet alloantigen Sit(a) and affects collagen-induced aggregation. (6/157)
A new platelet-specific alloantigen, termed Sit(a), was identified in a severe case of neonatal alloimmune thrombocytopenia. The Sit(a) alloantigen is of low frequency (1/400) in the German population. Immunochemical studies demonstrated that the Sit(a) epitopes reside on platelet glycoprotein (GP) Ia. Nucleotide sequence analysis of GPIa cDNA derived from Sit(a)-positive platelets showed C(2531)-->T(2531) point mutation, resulting in Thr(799)Met dimorphism. Analysis of genomic DNA from 22 Sit(a)-negative normal individuals showed that the Thr(799) is encoded by ACG(2532) (90.9%) or ACA(2532) (9.1%). To establish a DNA typing technique, we elucidated the organization of the GPIa gene adjacent to the polymorphic bases. The introns (421 bp and 1.2 kb) encompass a 142-bp exon with the 2 polymorphic bases 2531 and 2532. Polymerase chain reaction-restriction fragment length polymorphism analysis on DNA derived from 100 donors using the restriction enzyme Mae III showed that the Met(799) form of GPIa is restricted to Sit(a) (+) phenotype. Analysis of stable Chinese hamster ovary transfectants expressing allele-specific recombinant forms of GPIa showed that anti-Sit(a) exclusively reacted with the Glu(505)Met(799), but not with the Glu(505)Thr(799) and the Lys(505)Thr(799) isoforms. In contrast, anti-Br(a) (HPA-5b) only recognized the Lys(505)Thr(799) form, whereas anti-Br(b) (HPA-5a) reacted with both Glu(505)Thr(799) and Glu(505)Met(799) isoforms. These results demonstrated that the Met(799) is responsible for formation of the Sit(a) alloantigenic determinants, whereas amino acid 505 (Lys or Glu) specifically controls the expression of Br(a) and Br(b) epitopes, respectively. Platelet aggregation responses of Sit(a) (+) individuals were diminished in response to collagen, indicating that the Thr(799)Met mutation affects the function of the GPIa/IIa complex. (+info)Threonine-145/methionine-145 variants of baculovirus produced recombinant ligand binding domain of GPIbalpha express HPA-2 epitopes and show equal binding of von Willebrand factor. (7/157)
Glycoprotein (GP) Ibalpha is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex, with the von Willebrand factor (vWF) binding site residing on the amino-terminus. A threonine for methionine-145 replacement of GPIbalpha is associated with the human platelet antigen (HPA)-2 system. To study the structural and functional consequences of this mutation, both forms of GPIbalpha were expressed as calmodulin fusion proteins in insect cells. Both recombinant proteins were recognized by their respective alloantibodies, independent of glycosylation or intactness of disulfide bonds, and gave similar results to platelet-derived GPIbalpha in antibody detection assays. Resonant mirror studies showed that vWF binding was not affected by the HPA-2 mutation; however, vWF binding was partially inhibited by IgG HPA-2 antibodies. Our data are compatible with an involvement of the leucine-rich repeat domain of GPIbalpha in vWF binding and indicate that recombinant GPIbalpha may be used to detect HPA-2 antibodies. (Blood. 2000;95:205-211) (+info)Requirement of leucine-rich repeats of glycoprotein (GP) Ibalpha for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib-IX-V complex. (8/157)
The platelet glycoprotein (GP) Ib-IX-V complex mediates adhesion to von Willebrand factor (vWf) in (patho)physiologic thrombus formation. The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282). We have used mammalian cell expression of canine-human chimeras of GP Ibalpha, corresponding to precise structural boundaries, to demonstrate the first specific requirement for individual leucine-rich repeats for binding of vWf either induced by a modulator, ristocetin, or under hydrodynamic flow. Implicit in this approach was that the GP Ibalpha chimeras retained a functional conformation, a supposition confirmed by analyzing restoration of function to reversed human-canine chimeras and demonstrating that all chimeras bound vWf activated by botrocetin, a modulator that is indiscriminate between species. Leucine-rich repeats 2, 3, and 4 of GP Ibalpha were identified as being critical for vWf adhesion to GP Ib-IX-V. (+info)
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Human platelet antigen
Human platelet antigens (HPA) are polymorphisms in platelet antigens. These can stimulate production of alloantibodies (that is ... "Nomenclature of human platelet antigens". Vox Sang. 85 (3): 240-5. doi:10.1046/j.1423-0410.2003.00331.x. PMID 14516468. S2CID ... http://www.ebi.ac.uk/ipd/hpa/ Human+Platelet+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) v ... antibodies against other people's antigens) in recipients of transfused platelets from donors with different HPAs. These ...
Factor XI
Tuszynski GP, Bevacqua SJ, Schmaier AH, Colman RW, Walsh PN (Jun 1982). "Factor XI antigen and activity in human platelets". ... In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its ... Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human ... Fujikawa K, Chung DW, Hendrickson LE, Davie EW (May 1986). "Amino acid sequence of human factor XI, a blood coagulation factor ...
CD9
"Purification and partial characterization of CD9 antigen of human platelets". FEBS Letters. 264 (2): 270-4. doi:10.1016/0014- ... by use of human specific DNA probes". Human Genetics. 86 (3): 268-72. doi:10.1007/bf00202407. PMID 1997380. S2CID 27178985. ... Ninomiya H, Sims PJ (July 1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b" ... Benoit P, Gross MS, Frachet P, Frézal J, Uzan G, Boucheix C, Nguyen VC (January 1991). "Assignment of the human CD9 gene to ...
Integrin beta 3
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)". May, K. E.; Villar, J.; Kirtley, S.; Kennedy, ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation ... CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB3 Info with links in the Cell ... Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936 (1): 340-54. Bibcode:2001NYASA.936..340B. doi: ...
Induced stem cells
Generated platelets demonstrated an 85% reduction in class I HLA antigens. These platelets appeared to have normal function in ... DC-like antigen-presenting cells obtained from human induced pluripotent stem cells can serve as a source for vaccination ... Thus, the ability to generate platelet products ex vivo and platelet products lacking HLA antigens in serum-free media would ... The fact that human iPSCs are capable of forming teratomas not only in humans but also in some animal body, in particular mice ...
Red blood cell
"The structure and function of the molecules that carry human red blood cell and platelet antigens". Transfusion Medicine ... Approximately 25 of these membrane proteins carry the various blood group antigens, such as the A, B and Rh antigens, among ... there are about 4,000-11,000 white blood cells and about 150,000-400,000 platelets per microliter. Human red blood cells take ... lack of Kx antigen and greatly reduced expression of Kell antigens); RhD/RhCE - defines Rh Blood Group and the associated ...
Neonatal alloimmune thrombocytopenia
Davoren A, Curtis BR, Aster RH, McFarland JG (August 2004). "Human platelet antigen-specific alloantibodies implicated in 1162 ... Platelet antigens are inherited from both mother and father. NAIT is caused by antibodies specific for platelet antigens ... NAIT, hence, is caused by transplacental passage of maternal platelet-specific alloantibody and rarely human leukocyte antigen ... "Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201". Human ...
Plateletpheresis
Collecting the platelets from a single donor also simplifies human leukocyte antigen (HLA) matching, which improves the chance ... platelet increment at one hr x BSA (m2) / # platelets infused x 1011 Expected platelet increase (per μL) = platelets infused x ... Platelet count increase as well as platelet survival after transfusion is related to the dose of platelets infused and to the ... Not all platelet transfusions use platelets collected by automated apheresis. The platelets can also be separated from ...
P1PK blood group system
Shiga Toxin Binds Human Platelets Via Globotriaoslyceramide (Pk antigen) and a Novel Platelet Glycosphingolipid. Infect Immun ... The GLOB antigen (formerly P) is now the member of the separate GLOB blood group system. The P1PK antigens are carbohydrate ... The P antigen (later renamed P1) was first described by Karl Landsteiner and Philip Levine in 1927. The P1PK blood group system ... Rare p phenotype (absence of P1PK antigens caused by null mutations in A4GALT): anti-P1 (-), anti-P (-), anti-PP1Pk (-), and ...
CD109
... and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in ... CD109+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD109 genome location and CD109 gene ... CD109 (Cluster of Differentiation 109) is a human gene. CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute ... Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a ...
CD36
1989). "A new platelet-specific antigen, Naka, involved in the refractoriness of HLA-matched platelet transfusion". Vox ... Other human scavenger receptors related to CD36 are SCARB1 and SCARB2 proteins. Cluster of differentiation CD36 antigen GRCh38 ... CD36 is also known as glycoprotein IV (gpIV) or glycoprotein IIIb (gpIIIb) in platelets and gives rise to the Naka antigen. The ... Subsequent studies have shown that CD36 found on the surface of platelets. This antigen is recognized by the monoclonal ...
CD31
Human CD Antigen Chart (eBioscience) Mouse CD Antigen Chart (eBioscience) Human PECAM1 genome location and PECAM1 gene details ... Almendro N, Bellón T, Rius C, Lastres P, Langa C, Corbí A, Bernabéu C (December 1996). "Cloning of the human platelet ... Kirschbaum NE, Gumina RJ, Newman PJ (December 1994). "Organization of the gene for human platelet/endothelial cell adhesion ... "Platelet-endothelial cell adhesion molecule-1 is expressed by a subpopulation of human trophoblasts: a possible mechanism for ...
Duffy antigen system
"Fya/Fyb antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria". Proc Natl ... "Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum". Science. 338 (6112): 1348-51. ... "Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum". Science. 338 (6112): 1348-51. ... DARC+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Duffy at BGMUT Blood Group Antigen ...
CD84
... +protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD84 genome location and CD84 ... "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling". Blood. 106 (9): 3028-34. doi: ... de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (Sep 1997). "CD84 leukocyte antigen is a new member of the Ig ... Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B ...
Lentivirus
Antigen determinants that possess type-specific reactivity are found on the envelope. Antigen determinants that possess type- ... in humans and other mammalian species. The genus includes the human immunodeficiency virus (HIV), which causes AIDS. ... For example, a model of mouse hemophilia is corrected by expressing wild-type platelet-factor VIII, the gene that is mutated in ... Some groups have cross-reactive gag antigens (e.g., the ovine, caprine, and feline lentiviruses). Antibodies to gag antigens in ...
Immunoglobulin E
... and the antigen-presenting dendritic cells in both mice and humans. Binding of antigens to IgE already bound by the FcεRI on ... Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans. There are two types of Fcε ... IgE also plays a pivotal role in responses to allergens, such as: anaphylactic reactions to drugs, bee stings, and antigen ... Rihet P, Demeure CE, Bourgois A, Prata A, Dessein AJ (November 1991). "Evidence for an association between human resistance to ...
Platelet transfusion refractoriness
... platelet refractoriness Pathogen-reduced platelet component Alloantibodies to platelet antigens Human leucocyte antigen (HLA) ... antibodies Human platelet antigen (HPA) antibodies Immune complexes Other antibodies Drug-related antibodies Platelet ... PI = post-transfusion platelet count - pre-transfusion platelet count However, it is affected by the number of platelets given ... platelet component ABO mismatch between platelet component and recipient Number of platelets within the component if platelet ...
Granulocyte transfusion
If the recipient has antibodies against human leukocyte antigens (HLA), proteins found on the surface of white blood cells, the ... and reduce the efficacy of platelet transfusions and allogeneic stem cell transplants. In a 1934 experiment, Strumia gave ... Finally, people who receive granulocyte transfusions may develop antibodies against the human leukocyte antigens found on the ... and the development of antibodies against human leukocyte antigens, which can interfere with subsequent transfusions. ...
Succinic acid
SUCNR1 is one of the highest expressed G protein-coupled receptors on human platelets, present at levels similar to P2Y12, ... Succinate may enhance adaptive immunity by triggering the activity of antigen-presenting cells that, in turn, activate T-cells ... In humans, three HIF prolyl 4-hydroxylases regulate the stability of HIFs. Hydroxylation of two prolyl residues in HIF1α ... This pathway is exploited in metabolic engineering to net generate succinate for human use. Additionally, succinic acid ...
Geoffrey Tovey
Human Lymphocyte Antigens or HLAs), and the transfusion of platelets and later stem cells in the treatment of leukaemia. He ... He performed early work on the typing of red cells and their antigens, white blood cells ( ...
Integrin alpha 2
CD49b+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) PDBe-KB provides an overview of all the ... structure information available in the PDB for Human Integrin alpha 2 Moroi M, Jung SM (1997). "Platelet receptors for collagen ... Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. The ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ...
HPA
... a unit of pressure Human platelet antigen Human Protein Atlas Hydrogen pinch analysis Hypothalamic-pituitary-adrenal axis in ... UK polo governing body HPA Toucan human-powered aircraft built by Hertfordshire Pedal Aeronauts Hans Peter Anvin (born 1972), ... physiology High-performance addressing, in LCD displays Host protected area of computer data storage Human-powered aircraft ...
CD226
... platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a protein that in humans is encoded by the ... CD226+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD226 genome location and ... Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H (2006). "Expression of human CD226 on T ... CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells ...
Blood transfusion
... human platelet antigen). Recipients who lack this protein develop sensitization to this protein from prior transfusions or ... Antibodies to human neutrophil antigens (HNA) and human leukocyte antigens (HLA) have been associated with this type of ... Fast, LD; Dileone, G; Marschner, S (2011). "Inactivation of human white blood cells in platelet products after pathogen ... Although transfusions of platelets are far less numerous (relative to RBC), platelet storage lesion and resulting efficacy loss ...
Protein C inhibitor
"Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". European Journal of ... "Anticoagulant and antithrombotic properties of platelet protease nexin-1". Blood. 115 (1): 97-106. doi:10.1182/blood-2009-04- ... The human Protein C inhibitor have 19 amino acid signal peptide. The study of genomic DNA by restriction mapping, polymerase ... Yasuda T, Nadano D, Iida R, Tanaka Y, Nakanaga M, Kishi K (May 1992). "Discovery of a genetic polymorphism of human plasma ...
Interleukin 3
The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 ... It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype ... IL-3 is produced by T cells only after stimulation with antigens or other specific impulses. However, it was observed that IL-3 ... "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors". Cell ...
GRAP2
Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (Dec 1998). "Molecular cloning and expression of human grap- ... "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling ... Platelets. 13 (8): 459-64. doi:10.1080/0953710021000059431. PMID 12487779. S2CID 26192685. Yankee TM, Solow SA, Draves KD, ... Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, ...
MHC class I
In humans, the HLAs corresponding to MHC class I are HLA-A, HLA-B, and HLA-C. Class I MHC molecules bind peptides generated ... Histocompatibility+Antigens+Class+I at the US National Library of Medicine Medical Subject Headings (MeSH) MHC+Class+I+Genes at ... They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from ... It is likely that human MHC class Ib loci (HLA-E, -F, and -G) as well as MHC class I pseudogenes arose from MHC class Ia loci ( ...
Platelet factor 4
The gene for human PF4 is located on human chromosome 4. Platelet factor-4 is a 70-amino acid protein that is released from the ... PF4 complex is the antigen in heparin-induced thrombocytopenia (HIT), an idiosyncratic autoimmune reaction to the ... Han ZC, Bellucci S, Tenza D, Caen JP (April 1990). "Negative regulation of human megakaryocytopoiesis by human platelet factor ... The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole ...
Integrin alpha V
CD51+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGAV Info with links in the Cell Migration ... Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are ... "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet ... "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". Hermann P, Armant M, Brown E, ...
Rocky Mountain spotted fever
... including human beings. This tick is the most commonly identified species responsible for transmitting R. rickettsii to humans ... Both rOmpA and rOmpB are members of a family of surface cell antigens (Sca) which are autotransporter proteins; they act as ... Abnormal laboratory findings seen in patients with Rocky Mountain spotted fever may include a low platelet count, low blood ... The disease is caused by Rickettsia rickettsii, a type of bacterium that is primarily spread to humans by American dog ticks, ...
Tick infestation
A vaccine for humans to prevent tick-borne encephalitis was approved by the CDC in 2021 for use in the US. Though, this is not ... Parthasarathi, B. C.; Kumar, Binod; Ghosh, Srikant (July 2021). "Current status and future prospects of multi-antigen tick ... low levels of platelets in the body-an important component of blood clotting-deficiency results in worse bleeding). Ticks can ... Humans are not the preferred natural host, but the adult ticks, containing the bacteria known to cause Lyme disease, can attach ...
Lyme disease
Hyde FW, Johnson RC, White TJ, Shelburne CE (January 1989). "Detection of antigens in urine of mice and humans infected with ... or who have abnormally low levels of white or red cells or platelets in the blood, should be investigated for possible ... No human vaccines for Lyme disease are currently available. The only human vaccine to advance to market was LYMErix, which was ... Human expansion has also resulted in a reduction of predators that hunt deer as well as mice, chipmunks and other small rodents ...
CD151
Raph blood group system in the BGMUT blood group antigen gene mutation database Human CD151 genome location and CD151 gene ... identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263-70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID ... "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348-55. doi: ... Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S (1996). "SFA-1, a novel cellular gene induced by human T-cell ...
Singapore Cord Blood Bank
Singaporean patients who needed stem cell transplants were then facing difficulties in obtaining Human Leukocyte Antigen (HLA) ... white blood cells and platelets. The use of blood stem cells has emerged as a potentially curative option for the treatment of ...
Lassa fever
Imported cases have not manifested in larger epidemics outside of Africa due to a lack of human to human transmission in ... An ELISA test for antigen and Immunoglobulin M antibodies give 88% sensitivity and 90% specificity for the presence of the ... low platelets), and elevated aspartate transaminase levels in the blood. Lassa fever virus can also be found in cerebrospinal ... There is no vaccine for humans as of 2019. Researchers at the United States Army Medical Research Institute of Infectious ...
Waldenström macroglobulinemia
A low white blood cell count, and low platelet count in the blood may be observed. A low level of neutrophils (a specific type ... Bone marrow tumour cells express the following antigen targets CD20 (98.3%), CD22 (88.3%), CD40 (83.3%), CD52 (77.4%), IgM ( ... American Journal of Human Genetics. 79 (4): 695-701. doi:10.1086/507687. PMC 1592553. PMID 16960805. Treon, S. P.; Xu, L.; Yang ... Platelet aggregation studies are optional. Serum protein electrophoresis results indicate evidence of a monoclonal spike but ...
INPP5D
"Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets". The ... A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23 ... Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C (August 1996). "Cloning and expression of a human placenta ... Zhang S, Broxmeyer HE (January 1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2 ...
Pattern recognition receptor
CTLD is a ligand binding motif found in more than 1000 known proteins (more than 100 in humans) and the ligands are often not ... PRRs also mediate the initiation of antigen-specific adaptive immune response and release of inflammatory cytokines. The ... the platelet activation receptor for podoplanin on lymphatic endothelial cells and invading front of some carcinomas, and ... 10 functional members of the TLR family have been described in humans so far. Studies have been conducted on TLR11 as well, and ...
Index of biochemistry articles
... platelet glycoprotein GPIb-IX complex - platelet membrane glycoprotein - platelet-derived growth factor - platelet-derived ... CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion molecule - cell biology - cell cycle ... Human Genome Project - hybridization - hydrocarbon - hydrogen - hydrogen bond - hydrogenation - hydrogen-deuterium exchange - ... T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - TATA box - ...
Primary effusion lymphoma
Shin J, Lee JO, Choe JY, Bang SM, Lee JS (January 2017). "Human Herpesvirus 8-Unrelated Primary Effusion Lymphoma-Like Lymphoma ... low blood levels of platelets, high serum levels of IL6, and high levels of circulating KSHV/HHV8. PEL develops in patients ... or one of the various tests for hepatitis C antigen. Extracavitary PEL is diagnosed based on findings that their mass lesions ... This weakening is ascribed to KSHV/HHV8 infection that is commonly further promoted by concurrent human immunodeficiency virus ...
Mitogen
Scientists found that p28sis has a nearly identical amino acid sequence as human platelet-derived growth factor (PDGF). Thus, ... Lymphocytes can enter mitosis when they are activated by mitogens or antigens. B cells specifically can divide when they ... Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. ... Casciani, V; Marinoni, E (2008). "Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion ...
Vaccine hesitancy
Furthermore, the human body is capable of breaking down naturally occurring formaldehyde as well as the small amount of ... Indeed, a vaccine that provides accessible antigens in the absence of these other proteins may allow us to control the response ... Richardson PD, Mohammed SF, Mason RG, Steiner M, Kane R (2004). "Dynamics of platelet interaction with surfaces in steady flow ... For instance, the human papillomavirus (HPV) vaccine elicits a stronger immune response than infection by the virus itself. One ...
Catch bond
"Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF". Journal of ... These includes bonds between T cell antigen receptors (TCR) or pre-TCR and peptide presented by major histocompatibility ... platelet glycoprotein Ib and von Willebrand factor, and integrin alpha 5 beta 1 and fibronectin. Emphasizing their importance ... "The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet ...
List of Ig Nobel Prize winners
Reimers, E.; Eftestøl, S. (2012). "Response Behaviors of Svalbard Reindeer Towards Humans and Humans Disguised as Polar Bears ... Marazziti, D.; Akiskal, H. S.; Rossi, A.; Cassano, G. B. (1999). "Alteration of the platelet serotonin transporter in romantic ... J. Benveniste; P. Jurgens, W. Hsueh and J. Aissa ( 21-26 February 1997). "Transatlantic Transfer of Digitized Antigen Signal by ... Ghirlanda, S.; Jansson, L.; Enquist, M. (2002). "Chickens prefer beautiful humans" (PDF). Human Nature. 13 (3): 383-389. doi: ...
Antiphospholipid syndrome
A low platelet count and positivity for antibodies against β2-glycoprotein 1 or phosphatidylserine may also be observed in a ... McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen ... de Jong PG, Goddijn M, Middeldorp S (2013). "Antithrombotic therapy for pregnancy loss". Human Reproduction Update. 19 (6): 656 ... Other common findings, although not part of the APS classification criteria, are low platelet count, heart valve disease, and ...
Spleen
It can store platelets in case of an emergency and also clears old platelets from the circulation. Up to a quarter of ... In humans, up to a cup (240 ml) of red blood cells is held within the spleen and released in cases of hypovolemia and hypoxia. ... Assessment of IgM antibodies to viral capsid antigen (a rising titer) is indicated to confirm Epstein-Barr virus or ... In humans, the spleen is purple in color and is in the left upper quadrant of the abdomen. The spleen is underneath the left ...
Idiopathic multicentric Castleman disease
Pathogen - Human herpesvirus 8 (HHV-8) is the known causative agent in HHV-8-associated MCD, which has very similar symptoms ... platelet counts. Patients may also have elevations of molecules involved in inflammation (cytokines), such as Interleukin 6 (IL ... Staining with latency-associated nuclear antigen (LANA-1), a marker of HHV-8 infection, must be negative to diagnose iMCD. ... Castleman disease describes a group of at least 3 distinct disorders-Unicentric Castleman disease (UCD), human herpesvirus 8 ...
Plasma frozen within 24 hours
... that are directed against human leukocyte antigens (HLA). These antibodies are most numerous in women who have been pregnant ... Removing multiparous women from this limited donor pool would likely cause too great a shortage of platelets, resulting in more ... Plasma frozen within 24 hours after phlebotomy, commonly called FP24, PF‑24, or similar names, is a frozen human blood plasma ... This does not address the question of risk from plasma in other components, particularly apheresis platelets. ...
List of human clusters of differentiation
Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody ... Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-11.[permanent dead link] AbCam antigen poster (All ... "hcdm, Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-15. "hcdm, Human Cell Differentiation Molecules". ... "hcdm, Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-15. "hcdm, Human Cell Differentiation Molecules". ...
Innate immune system
Normal body cells are not recognized and attacked by NK cells because they express intact self MHC antigens. Those MHC antigens ... Members of every class of pathogen that infect humans also infect plants. Although the exact pathogenic species vary with the ... For example, beta-lysine, a protein produced by platelets during coagulation, can cause lysis of many Gram-positive bacteria by ... Dendritic cells are very important in the process of antigen presentation, and serve as a link between the innate and adaptive ...
Periodontal disease
As in other tissues, Langerhans cells in the epithelium take up antigens from the microbes, and present them to the immune ... I. As observed in human biopsy material". Journal of Periodontology. 49 (1): 1-8. doi:10.1902/jop.1978.49.1.1. PMID 340634. ... as it is associated with platelet and coagulation cascade activations, leading to thrombosis and thrombotic complications. ... Centre for Pet Nutrition has established that the bacteria associated with gum disease in dogs are not the same as in humans. ...
Apheresis
For apheresis platelet donation the donor's pre platelet count should be above 150 x 10^9/L. For apheresis plasma donation, the ... Some institutions use human serum albumin, but it is costly and can be difficult to find. Some advocate using fresh frozen ... and cellular antigen[citation needed] Leukoreduction Plasmapheresis Venipuncture Pediatric Apheresis Katherine, Abel (2013). ... The yield is normally the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets ...
Streptococcus
Group H streptococci rarely cause human illness unless a human has direct contact with the mouth of a canine. One of the most ... They possess no Lancefield antigens.[citation needed] The viridans streptococci are a large group of commensal bacteria that ... and platelets), and usually results in beta-hemolysis under the surface of blood agar. Streptolysin S is an oxygen-stable ... It is a particularly common GGS in humans, although it is typically found on animals. S. phocae is a GGS subspecies that has ...
White blood cell
These cells bind antigens presented on MHC I complex of virus-infected or tumour cells and kill them. Nearly all nucleated ... Maton D, Hopkins J, McLaughlin CW, Johnson S, Warner MQ, LaHart D, Wright JD, Kulkarni DV (1997). Human Biology and Health. ... All white blood cells are nucleated, which distinguishes them from the anucleated red blood cells and platelets. Types of ... Falcone FH, Haas H, Gibbs BF (December 2000). "The human basophil: a new appreciation of its role in immune responses". Blood. ...
Plasmodium knowlesi
It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human ... Laboratory tests of infected people nearly always show a low platelet count, although this rarely leads to bleeding problems. ... which is involved in displaying different antigens on the parasite surface to evade the immune system, and the Kir (knowlesi ... While Cyril Garnham had suggested in 1957 that P. knowlesi might naturally infect humans, the first documented case of a human ...
Use of a rapid method for genotyping human platelet antigen systems in neonatal alloimmune thrombocytopenia
|...
Use of a rapid method for genotyping human platelet antigen systems in neonatal alloimmune thrombocytopenia ... Use of a rapid method for genotyping human platelet antigen systems in neonatal alloimmune thrombocytopenia. Haematologica 1997 ... in which serology had provided inconclusive human platelet antigen (HPA) typing data. This method allowed for the ...
Immunofiuorescent detection of factor VIII-related antigen in human platelets and megakaryocytes<...
Immunofiuorescent detection of factor VIII-related antigen in human platelets and megakaryocytes. / Piovella, Franco; Ascari, E ... Immunofiuorescent detection of factor VIII-related antigen in human platelets and megakaryocytes. In: Pathophysiology of ... Dive into the research topics of Immunofiuorescent detection of factor VIII-related antigen in human platelets and ... Immunofiuorescent detection of factor VIII-related antigen in human platelets and megakaryocytes. Pathophysiology of ...
Просмотр EMRO Journal Articles (EMHJ) по теме
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias
The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc ... The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. ... Most individuals have leucine at position 33; these antigens are designated as human platelet alloantigen (HPA)-1a or PLA1; ... The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). On resting platelets, GP ...
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Progress Toward Hepatitis B and Hepatitis C Elimination Using a Catalytic Funding Model - Tashkent, Uzbekistan, December 6,...
Creatinine, aspartate aminotransferase, platelet, and hepatitis C virus core antigen to measure sustained virologic response.. ... MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services.. Use of ... ARCHITECT HCV Antigen Assay, Abbott Laboratories), and for creatinine, aspartate aminotransferase (AST), and platelet tests. An ... Hepatitis B surface antigen rapid diagnostic test.. § Hepatitis B virus enzyme linked immunosorbent assay, quantitative ...
TotalSeq™-D0146 anti-human CD69 antibody, CD69, FN50
... very early activation antigen (VEA), and MLR3. It is a member of the C-type lectin family, expressed as a disulfide-linked ... Lymphocyte, monocyte, and platelet activation, NK cell killing Cell Type B cells, Granulocytes, Langerhans cells, NK cells, ... Platelets, T cells, Thymocytes, Tregs Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules Antigen ... Antigen Details Structure C-type lectin, type II glycoprotein, 28/32 kD Distribution Activated T cells, B cells, NK cells, ...
PDGFRB gene: MedlinePlus Genetics
The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which ... beta-type platelet-derived growth factor receptor. *CD140 antigen-like family member B ... National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National ... The PDGFRβ protein is found in the cell membrane of certain cell types, where a protein called platelet-derived growth factor ...
Prolonged KI Polyomavirus Infection in Immunodeficient Child - Volume 18, Number 4-April 2012 - Emerging Infectious Diseases...
... from an 8/10 human leukocyte antigen-matched, CMV-positive, unrelated donor. Graft-versus-host disease prophylaxis consisted of ... cyclosporine A (from day −1) and methotrexate (days +1, +3, +6; 10 mg/m2). Leukocyte, granulocyte, and platelet engraftment ... Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, Identification of a third human polyomavirus. J Virol ... On day −83, human bocavirus was detected. On day −27, the occurrence of bilateral infiltrates was assessed, and pneumonia was ...
β2 Microglobulin Antibody, anti-human, REAdye lease™ | Releasable fluorochromes | MACS Antibodies | Products | Miltenyi Biotec ...
β2 microglobulin plays a role in the presentation of peptide antigens to the immune system. It has no transmembrane region and ... Distribution of antigen. leukocytes, platelets, endothelial cells, epithelial cells, tonsil. RRID. AB_2904635. ... Alternative names of antigen. Beta-2-microglobulin, B2M, β2M, CDABP0092, HDCMA22P. Distribution of antigen. leukocytes, ... MACSima™ Stain Support Kit, human. The MACSima Stain Support Kit, human contains support reagents and mixing vials required for ...
Professor Peter Collins - People - Cardiff University
Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological ... Heterogeneous detection of A-antigen on von Willebrand factor derived from platelets, endothelial cells and plasma. Thrombosis ... Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological ... Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin ...
WHO EMRO | Prevalence of ABO and Rh blood groups and their association with demographic and anthropometric factors in an...
They are also expressed on other human tissues such as vascular endothelium and epithelium, sensory neurons and platelets (4). ... The ABO and Rh blood groups were determined using the antigen-antibody agglutination test. The antisera were obtained from the ... Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood Transfus. 2013 ... Background: Blood groups appear to be markers for various human diseases and their distribution among different communities, ...
Search Research Outputs - Research Portal, King's College, London
Impact of Human Leucocyte Antigen epitope matched platelet transfusions in alloimmunised aplastic anaemia patients. Kallon, D. ... Neutrophil and platelet increases with luspatercept in lower-risk MDS: secondary endpoints from the MEDALIST trial. Garcia- ... An epitope-based approach of HLA-matched platelets for transfusion: A noninferiority crossover randomized trial. Marsh, J. C., ... Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment resistant MLL-rearranged ...
BD FACSVia FC | ULS
Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells...
Herein, we report that human Dectin-1 is a ligand for CLEC-2, another CLR expressed on platelets. Biochemical analyses revealed ... Human subjects: Leukapheresis products (non-clinical and de-identified) from donor blood were used as a source of human T cells ... 1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage ... 2008) Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles ...
Brilliant Violet 421 anti-human CD42b Antibody anti-CD42b - HIP1
CD42b is expressed on platelets and megakaryocytes. CD42b/c heterodimer forms a complex with CD42a and d and acts as the ... Antigen Details Structure Mucin, leucine-rich repeat family, 145 kD Distribution Platelets, megakaryocytes ... Human platelets were stained with anti-human CD42b (clone HIP1) Brilliant Violet 421™ (filled histogram) or mouse IgG1, κ ... Human platelets were stained with anti-human CD42b (clone HIP1) Brilliant Violet 421™ (filled histogram) or mouse IgG1, κ ...
Cd 41A Immunohistochemistry Bone Marrow - Preparation, Procedure, Cost, Normal Range | Practo
LOINC LP156720-7 - HLA-A+B+C IgG
... in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The ... HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets. Antibodies specific to HLA ... The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in ... Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC. ...
2011 Special Issue
Liang Tzung Lin - 研究成果 - 臺北醫學大學
Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia ... Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. Hsu, Y. L., Kuo, P. L., Lin, L. T. ... Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus. Wang, K. C., Chang, J. S., ... Contribution of human retroviruses to disease development-A focus on the HIV- And HERV-cancer relationships and treatment ...
Anti-stromal antigen 3-like 2 (pseudogene) Antibody Products | Biocompare
Compare Anti-stromal antigen 3-like 2 (pseudogene) Antibody Products from leading suppliers on Biocompare. View specifications ... Good CD32 Staining on Human Platelets CD32 is expressed on the platelet surface. CD32 Monoclonal Antibody (6C4 (CD32)) PerCP- ... Anti-stromal antigen 3-like 2 (pseudogene) Antibody Products. Stromal antigen 3-like 2 (pseudogene) is a human gene encoded by ... This antibody of MTHFD2 is good for WB with mouse tissue and human cell. Signal is strong and the ... Read Review ...
Monoclonal Antibody to Platelet Factor 4 (PF4) | MAA172Hu23 | Homo sapiens (Human) CLOUD-CLONE CORP.(CCC)
Chemiluminescent immunoassay for Antigen Detection.. LMA172Hu. Magnetic Luminex Assay Kit for Platelet Factor 4 (PF4) ,etc.. ... Monoclonal Antibody to Platelet Factor 4 (PF4). WB; IHC; ICC; IP.. SEA172Hu. ELISA Kit for Platelet Factor 4 (PF4). Enzyme- ... Monoclonal Antibody to Platelet Factor 4 (PF4). WB; IHC; ICC; IP.. MAA172Hu23. Monoclonal Antibody to Platelet Factor 4 (PF4). ... Magnetic Luminex Assay for Antigen Detection.. PSA172Hu01. Antibody Pair for Platelet Factor 4 (PF4). ELISA; CLIA; ELISPOT; ...
Major Histocompatibility Complex (MHC) - Lupus Research
In humans, histocompatibility antigens are called human leukocyte antigens (HLA) because they were originally discovered in ... Class I MHC antigens (HLA-A, HLA-B, and HLA-C) are found on all nucleated cells and platelets. Class II antigens (HLA-DR, HLA- ... A complex of genes on chromosome 6 that code for the antigens that determine tissue and blood compatibility. ... There are thousands of combinations of HLA antigens. ... DQ, and HLA-DP) are found on lymphocytes and antigen processing ...
Donating platelets with Canadian Blood Services
In a healthy person, a large number of platelets are manufactured and stored in the body. ... Platelets are the component of blood that helps with clotting. ... AB red blood cell types but also the Human Leukocyte Antigen ( ... Matching platelet donors and recipients HLA platelet matching Patients who receive multiple platelet transfusions sometimes ... How often can I donate platelets?. You can donate platelets as often as every 14 days. New platelet donors are encouraged to ...
Browsing DSpace | ZHAW digitalcollection
Immune-Mediated Thrombocytopenia-Current Approach - WSAVA 2003 Congress - VIN
... tumor antigens, microbial antigens) adsorbed to the platelet surface, or a non-specific binding of IgG to platelets. A direct ... Platelet life span studies in dogs with ITP have not been reported, but studies in humans with ITP showed a reduction of the ... Platelet-surface-bound antibodies could be "true" antiplatelet autoantibodies against an antigen of the platelet membrane, ... Target antigens for autoantibodies in human beings are epitopes within the glycoprotein (GP) IIb/IIIa or GP Ib/IX complex. GP ...
Klein, Harvey G. 2020 - Office of NIH History and Stetten Museum
The HLA (human leukocyte antigen) laboratory, which makes transfusing platelets, the clotting factor, clotting cell, much ... You have the human genome. Even with the human genome, if you didnt have powerful information technology you couldnt analyze ... and of course having the genome with the Human Genome Project. We look at the area for red cells and platelets on the genome ... But for our platelet collections, most of them are volunteer community donors, so its much easier for them to donate offsite ...
DeCS
Human Platelet Antigen Human Platelet Antigens Platelet Alloantigen Platelet Alloantigens Platelet Antigens, Human Platelet ... Antigens, Platelet Specific. Antigens, Platelet-Specific. Human Platelet Antigen. Human Platelet Antigens. Platelet Alloantigen ... Platelet Antigens, Human. Platelet Specific Antigens. Platelet-Specific Antigen. Platelet-Specific Antigens. ... Antigens, Human Platelet Entry term(s). Alloantigens, Platelet Antigens, Platelet Specific Antigens, Platelet-Specific ...
AntibodiesAggregationAntibodyMegakaryocytesSurface antigenLymphocytesReceptorCD31GlycoproteinSpecific AntigensForeign antigensNeonatal alloimmune thromProteinProteinsTransfusionFound on all nucleatedLymphocyteDonorGranulocytesEndothelial cellFactorMonocytesRole in the pathogenesisTarget antigenCellsEndotheliumThrombocytopeniaCarcinoembryonic AntigenMoleculesAlloimmunizationSerumInfectionMembraneFetalImmunePeripheralTransfusionsPlasmaBloodSolubleHepatitisIgG1VitroImmunofluorescenceGenesExtracellularFibrinogenImmunodeficiency VirusTissueBone
Antibodies14
- Platelets, lymphocytes, and megakaryocytes, specifically processed for the intracellular detection of antigens, were studied by indirect immunofluorescence techniques using monospecific antibodies directed against factor VUI-related antigen (F-VIII-RA). (elsevier.com)
- Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. (loinc.org)
- The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. (loinc.org)
- Various testing methods are used to detect antibodies to HLA antigens. (loinc.org)
- Patients who receive multiple platelet transfusions sometimes produce antibodies that fight the donated platelets and prevent them from performing their clotting function. (blood.ca)
- ITP is a disease in which antibodies (mainly IgG) bound to the surface of platelets result in their premature destruction by macrophages in the spleen and liver. (vin.com)
- Antibodies are thought to be directed against normal host platelet-surface antigens (antiplatelet autoantibodies), and the cause of this antibody production is unknown. (vin.com)
- AnnexinV+ MP (AnV+MP) from platelet poor plasma were measured using fluorescent monoclonal antibodies and flow cytometry. (ucl.ac.uk)
- The antibodies used to detect EMP, however, were mainly directed against antigens without EC specificity. (nih.gov)
- The invention relates to monoclonal antibodies and parts thereof which bind preferentially to active human platelets, to the nucleotide sequence and amino-acid sequence of the heavy and light chain of MAb BW 2128 and to an antigen associated with thrombospondin. (everypatent.com)
- Use of Radiolabelled Monoclonal Anti-CEA Antibodies for the Detection of Human Carcinomas by External Photoscanning and Tomoscintigraphy, Mach et al. (everypatent.com)
- Refractoriness to granulocyte transfusion involves either HLA or granulocyte-specific antibodies and is similar to platelet refractoriness, except that refractoriness to granulocyte transfusion results in the patient failing to respond clinically to the infused granulocytes. (medscape.com)
- Antibodies perform their function by recognizing antigens on the surface of the microbe which identifies it as a foreign object. (kaberaglobal.com)
- Along with antibodies, there are also many cells, chemicals, and proteins involved in destroying these antigens. (kaberaglobal.com)
Aggregation5
- The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
- Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, Westerm blotting, and inhibition of platelet aggregation 2 . (biolegend.com)
- The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin, and thrombospondin and is required for platelet aggregation and clotting. (practo.com)
- CD41 antigen acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibrinectin and vitronectin and mediates platelet adhesion and aggregation. (healthweblognews.info)
- Fibrinogen is an essential blood-clotting factor and is involved in a range of other functions, including platelet aggregation and smooth muscle proliferation. (cdc.gov)
Antibody14
- The section was stained using β2 Microglobulin Antibody, anti-human, PE (green) for 10 min at room temperature (A). β2 Microglobulin Antibody, anti-human, PE staining was released using the REAlease Release Reagent (B). Nuclei were visualized with Hoechst™ (blue). (miltenyibiotec.com)
- This antibody of MTHFD2 is good for WB with mouse tissue and human cell. (biocompare.com)
- Western Blot Analysis of human Jurkat cell lysate using CD31 Mouse Monoclonal Antibody (C31.12). (neobiotechnologies.com)
- The mouse monoclonal antibody HI30 recognizes an extracellular epitope on all isoforms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. (exbio.cz)
- Serology results were negative for EBV IgM and positive for EBV viral capsid antigen antibody IgG and EBV nuclear antigen antibody IgG, suggestive of past infection with a low level of viral reactivation. (consultant360.com)
- Immunohistochemical Localization and Molecular Characteristics of Three Monoclonal Antibody-Defined Epitopes Detectable on Carcinoembryonic Antigen (CEA), Bosslet et al. (everypatent.com)
- This antibody recognizes the human CD31 cell surface antigen, a 130kD glycoprotein expressed by platelets, endothelial cells, granulocytes and some lymphocytes. (raybiotech.com)
- 8. Human immunodeficiency virus (HIV)-1 or -2 antibody positive at screening. (who.int)
- Particle-enhanced assays are based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)
- CRP present in the test sample will form an antigen-antibody complex with the latex particles. (cdc.gov)
- A serum sample test showed a weak positive result for dengue virus by using IgM and IgG antibody tests, and a strong positive result for dengue virus nonstructural protein-1, or NS1, antigen, demonstrating acute dengue virus infection. (cdc.gov)
- This antibody is recommended for detection of RhoA in human, mouse, rat or other extracts. (cytoskeleton.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tubulin Polymerization Promoting Protein (TPPP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Megakaryocytes7
- Specific staining was observed in platelets of the peripheral blood from normal individuals and from patients with haemophilia A, and in megakaryocytes and platelets of bone marrow from normal subjects. (elsevier.com)
- The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
- CD42b is expressed on platelets and megakaryocytes. (biolegend.com)
- CD41a antigen, a calcium-dependent complex of CD41/CD61 (GPIIb/IIIa) expressed on normal platelets and megakaryocytes. (practo.com)
- The CD42a antigen is expressed on platelets and megakaryocytes. (beckman.com)
- Mouse monoclonal to CD41.TBP8 reacts with a calcium-dependent complex of CD41/CD61 ( GPIIb/IIIa), 135/120 kDa, expressed on normal platelets and megakaryocytes. (healthweblognews.info)
- Granule Proteins in Human Megakaryocytes: Application to Plastic-Embedded Bone Marrow Biopsy Specimens, Beckstead et al. (everypatent.com)
Surface antigen3
- The 1-year pilot program set a target of testing 250,000 adults for HBV and HCV infection and treating all patients who have active infection, including those who had a positive test result for hepatitis B surface antigen (HBsAg) and those who had a positive test result for HCV core antigen. (cdc.gov)
- In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
- 5. Hepatitis B surface antigen (HBsAg) positive at screening. (who.int)
Lymphocytes5
- In humans, histocompatibility antigens are called human leukocyte antigens (HLA) because they were originally discovered in large numbers on lymphocytes. (lupusresearch.org)
- Class II antigens (HLA-DR, HLA-DQ, and HLA-DP) are found on lymphocytes and antigen processing cells and are important in the specific immune response. (lupusresearch.org)
- CD8+ T lymphocytes kill target cells when they recognize antigen in associated with self MHC-I [5-8]. (scirp.org)
- CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (exbio.cz)
- They reside in tissues to activate both T lymphocytes and B lymphocytes that recognize foreign antigens. (kaberaglobal.com)
Receptor2
- The PDGFRB gene provides instructions for making a protein called platelet-derived growth factor receptor beta (PDGFRβ), which is part of a family of proteins called receptor tyrosine kinases. (medlineplus.gov)
- GP IIb/IIIa (fibrinogen receptor) has been identified as a target antigen in the dog. (vin.com)
CD311
- FS12 reacts with CD31 (PECAM-1), a 130-140 kDa member of the immunoglobulin gene superfamily that is expressed on cells of the vasculature, including platelets, endothelial cells, myeloid cells and certain lymphocyte subsets. (progen.com)
Glycoprotein4
- Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
- Target antigens for autoantibodies in human beings are epitopes within the glycoprotein (GP) IIb/IIIa or GP Ib/IX complex. (vin.com)
- The CD42a antigen (GPIX) is a 22 kDa single-chain membrane glycoprotein that forms a noncovalent complex with CD42b, CD42c and CD42d (GP1X, GP1b, GPV). (beckman.com)
- CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. (exbio.cz)
Specific Antigens3
- Identity of TSAs (tumor-specific antigens) in experimentally induced tumors and their existence on human tumors remained elusive until the molecular basis of T lymphocyte cell recognition was understood. (scirp.org)
- These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy. (bvsalud.org)
- A recipient who is immunocompetent may mount an immune response to the donor antigens (i.e., alloimmunization), resulting in various clinical consequences, depending on the blood cells and specific antigens involved. (medscape.com)
Foreign antigens1
- [ 1 ] This procedure introduces a multitude of foreign antigens and viable cells into the recipient that persist for a variable time. (medscape.com)
Neonatal alloimmune throm1
- We applied a polymerase chain reaction-sequence specific primer (PCR-SSP) method developed by other researchers to study 4 families of newborns with neonatal alloimmune thrombocytopenia (NAITP) in which serology had provided inconclusive human platelet antigen (HPA) typing data. (haematologica.org)
Protein10
- CD69 is a 27-33 kD type II transmembrane protein also known as activation inducer molecule (AIM), very early activation antigen (VEA), and MLR3. (biolegend.com)
- The PDGFRβ protein is found in the cell membrane of certain cell types, where a protein called platelet-derived growth factor attaches (binds) to it. (medlineplus.gov)
- The interaction of the released platelet factors and other plasma protein clotting factors results in a stronger patch on the injured site. (blood.ca)
- Protein Binding: Nedocromil is approximately 89% protein bound in human plasma over a concentration range of 0.5 to 50 µg/mL. (clustermed.info)
- A Thrombin-Sensitive Protein of Human Platelet Membranes, Baenziger et al. (everypatent.com)
- Isolation and Properties of a Thrombin-Sensitive Protein from Human Blood Platelets, Ganguly, J. Biol. (everypatent.com)
- In the morning of the second day after apheresis, the platelet count dropped, procalcitonine level was elevated, C-reactive protein level was elevated, and a slight skin rash developed. (cdc.gov)
- To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. (bvsalud.org)
- The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
- The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)
Proteins9
- Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
- The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
- The proteins encoded by some genes form antigens. (loinc.org)
- MHC-I molecules are integral membrane proteins found on all nucleated cell and platelets. (scirp.org)
- Platelets release preformed mediators and generate eicosanoids that regulate acute hemostasis and inflammation, but these anucleate cytoplasts are not thought to synthesize proteins or cytokines, or to influence inflammatory responses over time. (rupress.org)
- Multimerin: A Series of Large Disulfide-Linked Multimeric Proteins Within Platelets, Hayward et al. (everypatent.com)
- Recombinant small G-proteins and human platelet extract were separated by SDS-PAGE and transferred to a PVDF membrane according to the method given in this datasheet. (cytoskeleton.com)
- Furthermore, we discovered that children and adults who got KD during years as a child without developing CAA didn't react to the Fc proteins antigens and play a central part in keeping immunological tolerance [1,2]. (forgetmenotinitiative.org)
- It is an absolutely vital component of the selenium-dependent proteins that have several biological functions in human health, including an antioxidant function. (pharmanord.com)
Transfusion9
- These studies have been undertaken for several reasons: their importance in blood transfusion and organ transplantation, their application in genetic research, forensic pathology and anthropology and studying the ancestral relationships of human (6,7). (who.int)
- The earliest known blood transfusions occurred in 1665, and the first human blood transfusion was performed by Dr. Philip Syng Physick in 1795. (medscape.com)
- The first transfusion of human blood for the treatment of hemorrhage was performed by Dr. James Blundell in London in 1818. (medscape.com)
- Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
- Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
- Whole blood stored for more than 6 hours does not provide therapeutic platelet transfusion, nor does it contain therapeutic amounts of labile coagulation factors (factors V and VIII). (rnpedia.com)
- Refractoriness to platelet transfusion (an increase in the platelet count after platelet transfusion that is significantly lower than expected [e.g. (medscape.com)
- Mettre à jour les données sur la prévalence des infections transmissibles par transfusion en contexte de pandémie à coronavirus est très important pour la sécurité transfusionnelle dans notre milieu. (bvsalud.org)
- White cells and platelets in blood transfusion : proceedings of the Eleventh Annual Symposium on Blood Transfusion, Groningen 1986, organized by the Red Cross Blood Bank Groningen-Drenthe / edited by C. Th. (who.int)
Found on all nucleated1
- Class I MHC antigens (HLA-A, HLA-B, and HLA-C) are found on all nucleated cells and platelets. (lupusresearch.org)
Lymphocyte1
- CD69 is involved in early events of lymphocyte, monocyte, and platelet activation, and has a functional role in redirected lysis mediated by activated NK cells. (biolegend.com)
Donor5
- The patient received bone marrow cells (4.2 × 10 6 CD34-positive cells/kg) from an 8/10 human leukocyte antigen-matched, CMV-positive, unrelated donor. (cdc.gov)
- A single platelet treatment would require six to eight whole blood donors instead of just one plateletpheresis donor. (blood.ca)
- Matching is about finding a donor whose platelets will be accepted readily into the recipient's body. (blood.ca)
- If you are thinking of making your first platelet donation or want to book an appointment, call your local donor centre. (blood.ca)
- The immunologic mechanism for alloimmunization to antigens found on transfused cells involves presentation of the donor antigens by donor antigen-presenting cells (APCs), i.e., monocytes, macrophages, dendritic cells, and B cells, to recipient T cells. (medscape.com)
Granulocytes1
- Depending on the species (human or non-human) of blood, either 1.077 or 1.084 g/ml Ficoll is used, resulting in a perfect layer of mononuclear cells that are separated from plasma, platelets, granulocytes, and erythrocytes. (iqbiosciences.com)
Endothelial cell1
- Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
Factor3
- Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
- Fibrocytes also produce angiogenic factors, such as vascular endothelial growth factor and platelet-derived growth factor A, and thus have a potent effect on de novo blood vessel formation, as evidenced by studies in an in vivo Matrigel™ (BD Biosciences, Franklin Lakes, NJ, USA) model of angiogenesis. (ersjournals.com)
- A New Medium Improves Sampling for Determination of Platelet Factor 4 in Human Plasma, Osei-Bonsu et al. (everypatent.com)
Monocytes2
- The interaction between activated platelets and monocytes with endothelial cells and the subsequent formation of AnV+MP and PMA during ACS would be compatible with a direct pathogenic link between inflammatory and prothrombotic pathways in the pathogenesis of ACS and myocardial necrosis. (ucl.ac.uk)
- CLINICAL PHARMACOLOGY General: Nedocromil sodium has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. (clustermed.info)
Role in the pathogenesis1
- Introduction Inflammation and platelet activation play a pivotal role in the pathogenesis of acute coronary syndrome (ACS). (ucl.ac.uk)
Target antigen1
- Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow-Robin spaces was described in patients with NMO [called NMO-IgG (NMO-immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen. (ox.ac.uk)
Cells21
- The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
- CD69 is constitutively expressed by a subset of medullary mature thymocytes, platelets, mantle B cells, and certain CD4 + T cells in germinal centers of normal lymph nodes. (biolegend.com)
- CD40L is transferred to antigen presenting cells in vitro ( Gardell and Parker, 2017 ). (elifesciences.org)
- HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets. (loinc.org)
- Platelets are about a quarter of the size of red blood cells and are not whole cells but rather fragile cell fragments. (blood.ca)
- In vitro studies on cells obtained by bronchoalveolar lavage from antigen-sensitized macaque monkeys show that nedocromil sodium inhibits the release of mediators including histamine, leukotriene C4, and prostaglandin D2. (clustermed.info)
- Similar studies with human bronchoalveolar cells showed inhibition of histamine release from mast cells and beta-glucuronidase release from macrophages. (clustermed.info)
- Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
- Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD45 (HI30) PerCP-Cy™5.5. (exbio.cz)
- Human bone marrow (BM) niche includes several nonhematopoietic cells, including mesenchymal stromal cells (MSCs), osteoblasts, adipocytes, and endothelial and neural cells that offer physical support to hematopoietic stem progenitor cells (HSPCs) and regulate their homeostasis. (lww.com)
- 4 Due to the low frequency of mesenchymal progenitors in the human BM, where they only occur for approximately 0.001% to 0.01% of BM mononuclear cells (MNCs), ex vivo expansion of MSCs is necessary to reach sufficient numbers for clinical use. (lww.com)
- Bone marrow is a spongy material inside the bones that makes white blood cells, red blood cells, and platelets. (kidshealth.org)
- The chemistry panel is unremarkable, and the CBC reveals a white blood cell count of 4.6 × 10 3 cells/μL (reference range, 4.5-11 × 103 cells/μL), a hemoglobin level of 13.7 g/dL (reference range, 13.5-17.5 g/dL), a hematocrit of 43% (reference range, 41% to 50%), and a platelet count of 120 × 10 3 cells/μL μL (reference range, 150-450 × 103 cells/μL). (medscape.com)
- As the first-of-its-kind platform, the Microbubble-assisted UltraSound-guided Immunotherapy of Cancer (MUSIC) approach employs nanocomplexes combined with microbubbles to effectively deliver cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), an immunotransmitter involved in anticancer immunity, into antigen-presenting cells (APCs). (mdanderson.org)
- The immune system is a complex network of cells, tissues, molecules, and organs that spread throughout the human body. (kaberaglobal.com)
- Bone marrow is a spongy tissue located inside your bones that produces the white blood cells (WBC) to fight against infection, the platelets to assist blood clots, and the red blood cells to transport oxygen. (kaberaglobal.com)
- They represent antigen cells derived from white blood cells. (kaberaglobal.com)
- that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
- Our body fat is rich in mesenchymal stem cells [although it occurs in various concentrations in almost every tissue in the human body]. (pensummed.pro)
- Once harvested, separated, activated by photo-activation and combined with powerful growth factors harvested from your own platelets, the cells are returned to the body. (pensummed.pro)
- First is the realization that this class of cells can be isolated from almost every tissue in the human body. (pensummed.pro)
Endothelium1
- They are also expressed on other human tissues such as vascular endothelium and epithelium, sensory neurons and platelets (4). (who.int)
Thrombocytopenia1
- Examination of a peripheral blood smear is helpful to assess the presence of thrombocytopenia, although a platelet count is necessary to quantify its severity. (vin.com)
Carcinoembryonic Antigen1
- Antigenic Sites in Carcinoembryonic Antigen, Hammarstrom et al. (everypatent.com)
Molecules2
- The ABO blood group antigens (A, B, and H) are determined by carbohydrate molecules that are ordinarily considered as red blood cell antigens. (who.int)
- CD8+ recognized class I alloantigens or conventional antigens (e.g., viruses) associated with class I histocompatability molecules [5-8]. (scirp.org)
Alloimmunization1
- Each unit of platelets should raise the recipient's platelet count by 6000 to 10,000/mm3: however, poor incremental increases occur with alloimmunization from previous transfusions , bleeding, fever, infection, autoimmune destruction, and hypertension. (rnpedia.com)
Serum3
- Markers of inflammation (hs-CRP, IL-6, TNF-α, serum amyloid antigen (SAA) and platelet activation (soluble p-selectin and platelet monocyte aggregates (PMA) were measured using ELISA. (ucl.ac.uk)
- The Tandem-MP Ostase ImmunoEnzymetric Assay is an in vitro device for the quantitative measurement of Skeletal Alkaline Phosphatase (sALP), an indicator of osteoblastic activity, in human serum. (cdc.gov)
- In this study, we determined AQP4-Ab serum levels in 96 samples from eight NMO-IgG positive patients (median follow-up 62 months) in a newly developed fluorescence-based immunoprecipitation assay employing recombinant human AQP4. (ox.ac.uk)
Infection4
- Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)
- In humans, the disease follows infection by the Crimean-Congo hemorrhagic fever virus (CCHFV) and begins as flu-like symptoms that can rapidly progress to hemorrhaging and death. (mdpi.com)
- Treatment of malaria Malaria is a parasitic infection caused by the Plasmodium parasite, which is transmitted to humans through the bites of infected Anopheles mosquitoes. (mexapharma.com)
- Although guidelines have been established for prophylaxis against Pneumocystis carinii pneumonia (PCP) for adults with human immunodeficiency virus (HIV) infection, they have not been available for children (1). (cdc.gov)
Membrane2
- In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
- Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. (bvsalud.org)
Fetal1
- Maternal alloantibodies against the human platelet Ag (HPA)-1a allotype of the platelet β 3 integrin GpIIb/IIIa can cause severe fetal or neonatal hemorrhage. (ukhsa.gov.uk)
Immune4
- β2 microglobulin plays a role in the presentation of peptide antigens to the immune system. (miltenyibiotec.com)
- The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. (loinc.org)
- In one study 9% of 268 dogs with decreased platelet counts were diagnosed as having either primary ITP or Evans' syndrome (ITP and immune-mediated hemolytic anemia). (vin.com)
- Humans with a weak immune system have a higher risk of experiencing frequent infections and severe symptoms. (kaberaglobal.com)
Peripheral1
- 3.) immunophenotyping human peripheral whole blood and 4. (edu.hk)
Transfusions2
- Patients who have low platelets or platelets that don't function properly (e.g. cancer patients undergoing chemotherapy) need platelet transfusions as part of their treatment. (blood.ca)
- DHTRs and refractoriness to platelet transfusions are discussed in this article. (medscape.com)
Plasma4
- You're welcome to try different donation programs to see which you like best: blood, plasma or platelets. (blood.ca)
- Human platelet-MP (PMP), the main MP population in plasma, were prepared in vitro. (nih.gov)
- 2004) Assignment of the four disulfides in the N-terminal somatomedin B domain of native vitronectin isolated from human plasma. (en-academic.com)
- In humans, plasma IGF-I levels are barely detectable at birth, rise gradually during childhood, peak during mid-puberty until approximately 40 years of age, then decline gradually. (unitslab.com)
Blood21
- Blood groups appear to be markers for various human diseases and their distribution among different communities, ethnic groups and geographical boundaries varies over time. (who.int)
- Although the ABO blood group antigens are constant throughout life, the distribution of blood groups among different communities, ethnic groups and geographical boundaries do vary over time (5,9), even within the same region (10). (who.int)
- rapid detection of HLA-B27 antigen expression in erythrocyte-lysed whole blood (LWB). (edu.hk)
- A complex of genes on chromosome 6 that code for the antigens that determine tissue and blood compatibility. (lupusresearch.org)
- Platelets are the component of blood that helps with clotting. (blood.ca)
- If an injury or blood loss occurs, platelets are released, and a person's blood begins to clot to prevent excessive bleeding. (blood.ca)
- When a blood vessel is damaged, platelets stick to the edges of it, clustering together to plug the hole. (blood.ca)
- If the injury to the vessel is large, platelets alone will not stop the bleeding, so they release other factors that start blood clotting. (blood.ca)
- Platelets are donated through a process called plateletpheresis, which is much more efficient than gathering platelets from whole blood donations. (blood.ca)
- The platelet donation process follows the same steps as whole blood donation registration, screening, donation and after-care. (blood.ca)
- This makes 'platelet typing' crucial: matching not only A, O, B and AB red blood cell types but also the Human Leukocyte Antigen (HLA), which is more extensive and differentiating. (blood.ca)
- Ask us about donating platelets at your next whole blood donation or give us a call at 1 888 2 DONATE (1-888-236-6283). (blood.ca)
- Once I start donating platelets, can I still give blood? (blood.ca)
- If you do wish to donate both blood and platelets, you need to wait 56 days after either type of donation before making the other. (blood.ca)
- Blood is just as important as platelets: we appreciate your generosity and commitment, whatever you're able to give. (blood.ca)
- But instead of going straight into a collection bag, the blood passes through a centrifuge that separates out your platelets. (blood.ca)
- In the blood bank, 60% of units are centrifuged to separate the buffy coat in preparation for platelet separation. (cdc.gov)
- In 1939-1940, the Rhesus (Rh) blood group system was discovered, leading to the development of minor antigen compatibility testing. (medscape.com)
- Blood stem cell donation is similar to blood platelet donation. (curriculum-magazine.com)
- the disease caused by the cognate cel s from human cord blood. (who.int)
- Blood donors were included consecutively after a medical interview and screened for Human Immunodeficiency Virus, Hepatitis B virus, Hepatitis C virus and Treponema pallidum infections. (bvsalud.org)
Soluble1
- One example is barium, which is toxic to humans and animals in soluble form. (nhpolitician.com)
Hepatitis2
- Compulsory serologic testing was also done for Trypanosoma cruzi (Chagas disease), hepatitis B and C, Treponema pallidum (syphilis), human T-cell lymphotropic virus types 1 and 2, and HIV-1 and -2. (cdc.gov)
- For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
IgG11
- Human platelets were stained with anti-human CD42b (clone HIP1) Brilliant Violet 421™ (filled histogram) or mouse IgG1, κ Brilliant Violet 421™ isotype control (open histogram). (biolegend.com)
Vitro1
- These in vitro, and their expression in these human tumour virus. (who.int)
Immunofluorescence1
- Immunofluorescence analysis of a human tonsil cryosection fixed with 4% PFA. (miltenyibiotec.com)
Genes3
- A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
- Database of human genes associated with cellular senescence. (senescence.info)
- Evolution of Human Immunoglobulin k J Region Genes, Hieter et al. (everypatent.com)
Extracellular1
- Cultured Human Fibroblasts Synthesize and Secrete Thrombospondin and Incorporate it into Extracellular Matrix, Jaffe et al. (everypatent.com)
Fibrinogen1
- On resting platelets, GP IIb/IIIa is unable to bind fibrinogen or vWf. (medscape.com)
Immunodeficiency Virus1
- Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. (cdc.gov)
Tissue2
- Circulating fibrocytes display many functional properties, such as phagocytosis, antigen presentation, cytokine and connective tissue matrix production, and the capacity to proliferate and differentiate. (ersjournals.com)
- Tissue typing or HLA (human leukocyte antigen) typing. (kidshealth.org)
Bone1
- Lengthening of long bones in humans occurs in a particular area of the bone. (studyinnovations.com)