Antibodies, Heterophile: Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.Antigens, Heterophile: Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.Infectious Mononucleosis: A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.Forssman Antigen: A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.Immunoconglutinins: Autoantibodies directed against newly-formed EPITOPES created as the COMPLEMENT cascade is activated and the proteins involved change their conformations.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Hemagglutination Tests: Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)Latex Fixation Tests: Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)False Positive Reactions: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Antigens, Polyomavirus Transforming: Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

Induction of complement attack on human cells by Gal(alpha1,3)Gal xenoantigen expression as a gene therapy approach to cancer. (1/163)

Galactose(alpha1,3)galactose on the surface of cells of non-primate organs is the major xenoantigen responsible for hyperacute rejection in xenotransplantation. The antigen is synthesised by (alpha1, 3)galactosyl transferase. Humans lack this enzyme and their serum contains high levels of pre-existing natural antibody which recognises the structure and activates complement. We have evaluated in vitro the potential for delivery of this enzyme to sensitise human cells to complement attack as a gene therapy approach to cancer. Retrovirus-mediated delivery of (alpha1,3)galactosyl transferase resulted in high level expression which led to serum-mediated lysis of five human cell targets, including endothelial and primary melanoma cells. Lysis was specific for those cells expressing the antigen in a mixed cell population. The mechanism of cell lysis mimicked that involved in hyperacute rejection: activation of the classical complement pathway by natural antibody specific for galactose(alpha1,3)galactose. The degree of lysis was determined by both the level of specific antibody and the expression of glycophosphatidylinositol-linked complement regulatory proteins. We conclude that expression of (alpha1,3)galactosyl transferase is a promising new therapeutic approach for cancer gene therapy, avoiding toxicity problems associated with application of prodrugs and with the potential to elicit further immunological responses.  (+info)

The human antibody response to porcine xenoantigens is encoded by IGHV3-11 and IGHV3-74 IgVH germline progenitors. (2/163)

Preformed and induced Ab responses present a major immunological barrier to the use of pig organs for human xenotransplantation. We generated IgM and IgG gene libraries established from lymphocytes of patients treated with a bioartificial liver (BAL) containing pig hepatocytes and used these libraries to identify IgVH genes that encode human Ab responses to pig xenoantigens. Genes encoded by the VH3 family are increased in expression in patients following BAL treatment. cDNA libraries representing the VH3 gene family were generated, and the relative frequency of expression of genes used to encode the Ab response was determined at days 0, 10, and 21. Ig genes derived from the IGHV3-11 and IGHV3-74 germline progenitors increase in frequency post-BAL. The IGHV3-11 gene encodes 12% of VH3 cDNA clones expressed as IgM Abs at day 0 and 32.4-39.0% of cDNA clones encoding IgM Abs in two patients at day 10. IGHV3-11 and IGHV3-74 genes encoding IgM Abs in these patients are expressed without evidence of somatic mutation. By day 21, an isotype switch occurs and IGHV3-11 IgVH progenitors encode IgG Abs that demonstrate somatic mutation. We cloned these genes into a phagemid vector, expressed these clones as single-chain Abs, and demonstrated that the IGHV3-11 gene encodes Abs with the ability to bind to the gal alpha (1,3) gal epitope. Our results demonstrate that the xenoantibody response in humans is encoded by IgVH genes restricted to IGHV3-11 and IGHV3-74 germline progenitors. IgM Abs are expressed in germline configuration and IgG Abs demonstrate somatic mutations by day 21.  (+info)

The Th1/Th2 nature of concurrent immune responses to unrelated antigens can be independent. (3/163)

We tested the independence hypothesis, namely that the Th1/Th2 nature of concurrent immune responses, generated in the same secondary lymphoid organ to non-cross-reacting Ags, can be independently determined. Some infectious agents and some adjuvants contain modulatory molecules that affect the Th1/Th2 nature of immune responses in a non-Ag-specific manner. We therefore excluded infectious agents as Ags and the use of adjuvants to generate immune responses. We first show that the dose of xenogeneic RBC administered i.v. determines the Th1/Th2 nature of the splenic immune response. Low doses generate a virtually exclusive Th1 response, whereas a higher dose induces either a mixed Th1/Th2 or a predominantly Th2 response, and stimulates the production of specific Abs. We immunized individual mice simultaneously with a low dose of one kind of xenogeneic RBC and with a higher dose of another non-cross-reacting xenogeneic RBC and assessed the Th1/Th2 nature of the immune responses generated in the spleen to each kind of RBC. The Th1/Th2 nature of the response to each RBC in doubly immunized mice was indistinguishable from that of the corresponding immune response in singly immunized mice. We discuss the significance of our findings for understanding immune class regulation, and the possible reasons why such independence is not always seen.  (+info)

Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition. (4/163)

T cell expression of class II MHC/peptide complexes may be important for maintenance of peripheral self-tolerance, but mechanisms underlying the genesis of class II MHC glycoproteins on T cells are not well resolved. T cell APC (T-APC) used herein were transformed IL-2-dependent clones that constitutively synthesized class II MHC glycoproteins. When pulsed with myelin basic protein (MBP) and injected into Lewis rats, these T-APC reduced the severity of experimental autoimmune encephalomyelitis, whereas unpulsed T-APC were without activity. Normal MBP-reactive clones cultured without APC did not express class II MHC even when activated with mitogens and exposed to IFN-gamma. However, during a 4-h culture with T-APC or macrophage APC, recognition of MBP or mitogenic activation of responder T cells elicited high levels of I-A and I-E expression on responders. Acquisition of class II MHC glycoproteins by responders was resistant to the protein synthesis inhibitor cycloheximide, coincided with transfer of a PKH26 lipophilic dye from APC to responders, and resulted in the expression of syngeneic and allogeneic MHC glycoproteins on responders. Unlike rested I-A- T cell clones, rat thymic and splenic T cells expressed readily detectable levels of class II MHC glycoproteins. When preactivated with mitogens, naive T cells acquired APC-derived MHC class II molecules and other membrane-associated proteins when cultured with xenogeneic APC in the absence of Ag. In conclusion, this study provides evidence that APC donate membrane-bound peptide/MHC complexes to Ag-specific T cell responders by a mechanism associated with the induction of tolerance.  (+info)

HLA-E and HLA-G expression on porcine endothelial cells inhibit xenoreactive human NK cells through CD94/NKG2-dependent and -independent pathways. (5/163)

Human NK cells contribute a significant role to host defense as well as xenogeneic cytotoxicity. Previous studies using human 721.221 cell line have shown that peptides derived from the leader sequence of the HLA-G binds and up-regulates the surface expression of HLA-E molecules, which was considered to consequently provide negative signals to human NK cells. However, the direct role of HLA-G in inhibiting human NK cells remains controversial. In this study, we showed that the expression of HLA-G or HLA-E in porcine endothelial cells directly protected sensitive porcine cells from human NK cell-mediated xenogeneic cytotoxicity. Ab blocking assays using F(ab')2 of the HLA class I-specific mAb PA2.6 indicated that the protection was directly mediated by the expression of HLA-G and HLA-E on the porcine cells. The HLA-E-mediated protection was blocked by anti-human CD94 Ab. In addition, the engagement of HLA-E lead to the phosphorylation of the CD94/NKG2 complex and the recruitment of SH2 domain-containing protein phosphatase 1 (SHP-1) to the complex. Therefore, HLA-E protected porcine cells from xenoreactive human NK cells through a CD94/NKG2-dependent pathway. In contrast, HLA-G inhibited human NK cells in the absence of CD94/NKG2 phosphorylation or SHP-1 recruitment, and the inhibition was not blocked by anti-CD94 Ab. Therefore, HLA-G protected porcine cells from human NK cells through a CD94/NKG2-independent pathway. These results demonstrated that both HLA-E and HLA-G could directly inhibit human NK cells in the absence of other endogenous HLA class I molecules. These results also have practical implications in preventing xenograft rejection mediated by human NK cells.  (+info)

Xenotransplantation: the importance of the Galalpha1,3Gal epitope in hyperacute vascular rejection. (6/163)

The transplantation of organs from other species into humans is considered to be a potential solution to the shortage of human donor organs. Organ transplantation from pig to human, however, results in hyperacute rejection, initiated by the binding of human natural antidonor antibody and complement. The major target antigen of this natural antibody is the terminal disaccharide Galalphal,3Gal, which is synthesized by Galbeta1,4GlcNAc alpha1,3-galactosyltransferase. Here we review our current knowledge of this key enzyme. A better understanding of structure, enzyme properties, and expression pattern of alpha1,3-galactosyltransferase has opened up several novel therapeutic approaches to prevent hyperacute vascular rejection. Cloning, and expression in vitro of the corresponding cDNA, has allowed to develop strategies to induce immune tolerance, and deplete or neutralize the natural xenoreactive antibody. Elucidation of the genomic structure has led to the production of transgenic animals that are lacking alpha1,3-galactosyltransferase activity. A detailed knowledge of the enzyme properties has formed the basis of approaches to modify donor organ glycosylation by intracellular competition. Study of the expression pattern of alpha1,3-galactosyltransferase has helped to understand the mechanism of hyperacute rejection in discordant xenotransplantation, and that of complement-mediated, natural immunity against interspecies transmission of retroviruses.  (+info)

Taking lessons from dendritic cells: multiple xenogeneic ligands for leukocyte integrins have the potential to stimulate anti-tumor immunity. (7/163)

Expression of large numbers of different costimulatory integrin ligands (CILs) attributes dendritic cells with an ability to induce primary anti-tumor immune responses. Here, we show that optimized gene transfer of the xenogeneic (human) CILs VCAM-1, MAdCAM-1 and ICAM-1 causes rapid and complete rejection of established mouse EL-4 tumors, and generates prolonged systemic anti-tumor immunity; whereas human E-cadherin weakly slows tumor growth. In each case the immune response was mediated by CD8+ T cells and NK cells, accompanied by augmented tumor-specific cytolytic T cell (CTL) activity involving both the perforin and Fas-ligand pathways. Adoptive transfer of splenocytes from cured mice rapidly cleared established tumors in recipients. The mechanism for CIL-mediated immunity is unknown, but may involve CTL-facilitated tumor lysis, since CTLs were generally twice as efficient at killing CIL-transfected tumor cells than parental tumor cells. Optimized CIL-based gene therapy may provide an approach to complement or replace conventional DC adoptive cell therapy for suppressing tumor growth.  (+info)

Naturally developing memory T cell xenoreactivity to swine antigens in human peripheral blood lymphocytes. (8/163)

Naturally developing xenospecific Abs are well-documented barriers to xenograft transplantation in humans, but whether analogous xenoreactive T cell immunity develops is not known. We used an enzyme-linked immunospot assay to determine the frequency and cytokine profiles of xenoreactive PBLs from a panel of human volunteers. Because naive T cells produce only IL-2 in short term culture, IFN-gamma production by this approach is a measure of a memory immune response. Stimulation of human PBLs or purified T lymphocytes with stimulator cells from inbred swine revealed a high frequency of IFN-gamma producers with 5-fold fewer IL-2 producers. In contrast, lymphocytes obtained from neonatal umbilical cord blood contained swine-specific IL-2 producers but few IFN-gamma producers, which is what one would expect to find with a naive phenotype. Moreover, PBLs from adults with a history of abstention from pork consumption responded to swine cells with a significantly lower frequency of IFN-gamma producers than PBLs from adults with unrestricted diets did, suggesting that pork consumption may result in priming of swine-specific T cell immunity. Our findings provide the first evidence for naturally occurring xenospecific T cell immunity in humans. The detected strength of this memory response suggests that it will present a formidable barrier to transplantation of swine organs.  (+info)

*Heterophile antigen

Heterophile antigens: certain antigens of similar nature, if not identical, present in different tissues in different ... Example: Forssman antigen, cross reacting microbial antigen so antibodies to these antigens produced by one species cross react ... hetereogenetic antigen is shared by different species. Other heterophile antigen are responsible for some diagnostic ... Therefore antibodies are produced in rabit serum by injecting antigen(antiforssman antibodies). ...

*Heterophile

... antibodies are antibodies induced by external antigens (heterophile antigens). Some cross-react with self-antigens ... Heterophile antigen An immunoassay is a biochemical test, frequently used in medical diagnostic testing, that measures the ... These are considered heterophile antibodies. In clinical diagnosis, the heterophile antibody test specifically refers to a ... Heterophile antibodies can cause significant interference in any immunoassay. The presence of a heterophile antibody is ...

*John Forssman

He is known for discovery of the "Forssman antigen", defined as a glycolipid heterophile antigen found on tissue cells of many ... His name is also associated with the following two terms: "Forssman antibody" (heterophile antibody) and "Forssman reaction", ... also referred to as a "Forssman antigen-antibody reaction". Über die Ursachen, welche die Wachsthumsrichtung der peripheren ...

*Heterophile antibody test

Heterophile also can mean that it is an antibody that reacts with antigens other than the antigen that stimulated it (an ... Elgh, F; Linderholm, M (1996). "Evaluation of six commercially available kits using purified heterophile antigen for the rapid ... It has the following characteristics: VCAs (Viral Capsid Antigen) of the IgM class, antibodies to EBV early antigen (anti-EA), ... The test relies on the agglutination of the sheep RBCs by heterophile antibodies in patient's serum. Heterophile means it ...

*Index of immunology articles

Herd immunity Heterophile Heterophile antigen Heterosubtypic immunity Histamine Histocompatibility Human leukocyte antigen ... opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen Antigen presentation Antigen ... DAMPs Danger model Defensin Degranulation Dendritic cell Dextran 1 Dispanin Dog leukocyte antigen Drug resistance Duffy antigen ... Fc receptor Fc receptor-like molecule FcεRI Fibroblast-like synoviocyte FITkit FluoroSpot Forssman antigen Fragment antigen- ...

*History and naming of human leukocyte antigens

Rapaport FT, Kano K, Milgrom F (1968). "Heterophile antibodies in human transplantation". J. Clin. Invest. 47 (3): 633-42. doi: ... The Hu-1 antigens were renamed the Human-lymphoid (HL) allo-antigens (HL-As). Allo-antigen comes from the observation that a ... Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were ... As a result, scientists were able to identify a few antigens. At first the first antigens were called the Hu-1 antigens and ...

*Cross-reactivity

In immunology, the cross-reactivity has a more narrow meaning of the reaction between an antibody and an antigen that differs ... An example of helpful cross-reactivity is in heterophile antibody tests, which detect Epstein-Barr virus using antibodies that ... For example, the tetanus toxin is a single protein macromolecular antigen but will stimulate many immune responses due to the ... Contact with a complex antigen such as a virus will stimulate multiple immune responses to the virus' different macromolecules ...

*List of MeSH codes (D12.776)

... antigen, b-cell MeSH D12.776.377.715.548.950.500 - antigens, cd79 MeSH D12.776.377.715.647.100 - alpha-macroglobulins MeSH ... heterophile MeSH D12.776.377.715.548.114.224 - antibodies, monoclonal MeSH D12.776.377.715.548.114.224.570 - muromonab-cd3 MeSH ... antigen-antibody complex MeSH D12.776.377.715.548.114.301 - antitoxins MeSH D12.776.377.715.548.114.301.138 - antivenins MeSH ... antigens, polyomavirus transforming MeSH D12.776.624.664.520.420 - papillomavirus e7 proteins MeSH D12.776.624.664.520.750 - ...

*List of MeSH codes (D12.776.124)

... antigen, b-cell MeSH D12.776.124.486.485.950.500 -- antigens, cd79 MeSH D12.776.124.790.106.050 -- alpha 1-antichymotrypsin ... heterophile MeSH D12.776.124.486.485.114.224 -- antibodies, monoclonal MeSH D12.776.124.486.485.114.224.570 -- muromonab-cd3 ... antigens, cd46 MeSH D12.776.124.486.274.920.250 -- complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 -- ... antigen-antibody complex MeSH D12.776.124.486.485.114.301 -- antitoxins MeSH D12.776.124.486.485.114.301.138 -- antivenins MeSH ...

*Pharyngitis

The heterophile test can be used if this is suspected. Herpes simplex virus can cause multiple mouth ulcers. Measles Common ... Otherwise a rapid antigen detection test (RAPD) or throat swab is recommended. Other conditions that can produce similar ...

*Pregnancy test

Direct measurement of antigens, such as hCG, was made possible after the invention of the radioimmunoassay in 1959. ... These include choriocarcinoma and other germ cell tumors, IgA deficiencies, heterophile antibodies, enterocystoplasties, ...
Acute vascular rejection in pig-to-primate xenotransplantation involves recognition and damage of porcine (po) endothelial cells (EC) by human (hu) leukocytes, probably including natural killer (NK) cells. To study such interactions we analyzed rolling and static adhesion of hu NK cells to po EC. T...
Porcine SWC8小鼠单克隆抗体[MIL3](ab34020)可与猪样本反应并经IHC, Flow Cyt实验严格验证,被4篇文献引用。所有产品均提供质保服务,中国75%以上现货。
In view of the participation of vascular endothelial cells (EC) in a wide range of normal and pathological conditions, phenotypic heterogeneity of EC is an important concept for consideration:...
Heterophile definition is - of, relating to, or being an antibody circulating in blood serum that is reactive with antigen originating in a different species. How to use heterophile in a sentence.
Hiai, H; Shisa, H; Nishizuka, Y; and Miyawaki, H, "An antigen-binding cell tumor. Heterophile cold hemagglutinin as a membrane-bound receptor on a mouse lymphoma." (1974). Subject Strain Bibliography 1974. 975 ...
Looking for online definition of Forssman antigen in the Medical Dictionary? Forssman antigen explanation free. What is Forssman antigen? Meaning of Forssman antigen medical term. What does Forssman antigen mean?
Looking for online definition of xenoantibody in the Medical Dictionary? xenoantibody explanation free. What is xenoantibody? Meaning of xenoantibody medical term. What does xenoantibody mean?
The sheep cell agglutination test or heterophile antibody reaction, as it is also called, is a laboratory procedure of considerable value in clinical medicine. In this country one frequently speaks alternately of the Paul-Bunnell test; and in Europe it is often referred to as the Hanganutziu-Deicher reaction. In 1911 Forssman1 recognized the nonspecificity of certain antigen-antibody reactions. The terms "heterogenetic," "heterophilic," or "heterophile" are applied to those antibodies that react with an antigen (sheep erythrocytes) which seemingly had nothing to do with their development. One type of heterophile antibody is known as the Forssman antibody, but there are other varieties ...
Synonyms for Antibodies, heterophile in Free Thesaurus. Antonyms for Antibodies, heterophile. 4 synonyms for infectious mononucleosis: glandular fever, kissing disease, mono, mononucleosis. What are synonyms for Antibodies, heterophile?
Looking for Antibodies, heterophile? Find out information about Antibodies, heterophile. acute infectious disease of older children and young adults, occurring sporadically or in epidemic form, also known as mono, glandular fever, and kissing... Explanation of Antibodies, heterophile
PURPOSE OF REVIEW: This review describes the most recent progress in xeno lung transplantation (XLTx) to date. It describes the potential mechanisms of early xeno lung graft loss, as well as the latest therapeutic strategies to overcome them. RECENT FINDINGS: Using ex-vivo perfusion models of porcine lungs with human blood, the use of genetically modified pig lungs along with novel pharmaceutical approaches has recently been studied. Strategies that have demonstrated improved lung survival include the knockout of known xenoantigens (GalTKO and N-glycolylneuraminic acid-KO), genes that regulate complement activation (hCD46 and hCD55), as well as the inflammation/coagulation cascade (human leukocyte antigen-E, human thrombomodulin, human endothelial protein C receptor, hCD47, hCD39, hCD73 and heme oxygenase-1 ...
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Heterophile abs. Abs in the samples against abs in the assay. Only way to remove is review your data and locate high false positives. Add into your sample buffer non-specific ab (IgG) of the species used as capture and detector in your system and check with the false positive. ,,use this buffer and pre-incubate the samples to bind up the heterophile ab,, Once the false positive is reduced or eliminated test a select few of your samples. Hopefully, the samples will line up according to the conentration you expect ...
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities.
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SWISS-MODEL Template Library (SMTL) entry for 6s04.1. Crystal structure of an inverting family GH156 exosialidase from uncultured bacterium pG7 in complex with N-glycolylneuraminic acid
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Looking for heterophile antibody test? Find out information about heterophile antibody test. heterophile agglutination test Explanation of heterophile antibody test
Mixed xenogeneic bone marrow reconstitution (mouse + rat----mouse) results in stable mixed lymphopoietic chimerism (1-48% rat), long-term survival, and the induction of stable functional donor-specific transplantation tolerance to xenoantigens in vivo. To examine the role of negative selection of potentially xenoreactive T lymphocytes during tolerance induction across a species barrier, mixed xenogeneic chimeras (mouse + rat----mouse) were prepared and analyzed using a mixture of mouse and rat bone marrow cells for relative T cell receptor (TCR)-V beta expression on mouse T cells. In mixed xenogeneic chimeras (B10 mouse + rat----B10 mouse), T cell maturation proceeded normally in the presence of rat bone marrow-derived elements, and functional donor-specific tolerance to rat xenoantigens was present when assessed by mixed lymphocyte reactivity in vitro. V beta 5, which is expressed at high (undeleted) levels in normal B10 mice, was consistently deleted in B10 recipients of Wistar Furth (WF), but ...
J:188842 Bergfeld AK, et al., Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. J Biol Chem. 2012 Aug 17;287(34):28865-81 ...
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Materials sedimentable at high speed (approximately 27,000 R.P.M.) were found in all normal and neoplastic tissues studied. They are carriers of the Forssman antigen and of the Wassermann hapten.. These heavy materials exhibit species, organ, and individual specificity and produce several antibodies which can be demonstrated by absorption tests. Heavy materials from chicken sarcoma and chicken spleen could not be distinguished by complement fixation tests.. ...
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Xenotransplantation is the transplanting of animal tissues and organs into a human, and is being studied as a substitute for human organ donors.
How its done: Doctors take an organ that was donated by an animal source (most commonly pigs are used in this process) and surgically implant it into a human recipient that needs the new organs ...
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Porcine circovirus type 2 Capsid antibody for IHC, IHC-P, WB. Anti-Porcine circovirus type 2 Capsid pAb (GTX128120) is tested in Porcine circovirus type 2 samples. 100% Ab-Assurance.
Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter jejuni and Pasteurella multocida
Tissue-engineered (TE) corneas were fabricated from porcine collagen cross-linked with 1-ethyl-3-(3-dimethyl aminoproplyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS), and were transplanted into BALB/c mice orthotopically using a full-thickness penetrating keratoplasty (PKP) procedure. The biocompatibility was evaluated by assessing both local and systemic immune responses. Myeloid cells including granulocytes and macrophages were the main infiltrating cells in recipient cornea and in retro-TE corneal membrane which developed 7-10 days post surgery. Sodium citrate was found to be effective in reducing fibrin accumulation in anterior chamber post grafting at early time points, but it did not prevent formation of the retro-TE corneal membrane. No significant T cell activation was observed in the submandibular draining lymph nodes (SMDLN) by flow cytometry. Anti-porcine type I collagen IgG antibodies were detected in the serum of grafted mice from 2 weeks post grafting and the concentration of ...
0113] Free Neu5Gc can be taken up by human epithelial cells from an exogenous source and incorporated into different subcellular fractions. Evidence was presented suggesting that the small amounts of Neu5Gc found in some human tissues originated from dietary sources and showed that human Caco-2 cells (human epithelial cells from a primary colon carcinoma) in culture could metabolically incorporate free Neu5Gc, as determined by a Western blot of a total homogenate, using and anti-Neu5Gc antibody. Increasing incorporation of Neu5Gc was found in the total homogenate fraction of the cells over time, with the highest level reached after incubation with 3 mM Neu5Gc for 3 days. Moreover, Western blotting with an anti Neu5Gc antibody demonstrated metabolic incorporation of Neu5Gc into glycoproteins of these cells. The partitioning of the exogenous Neu5Gc into different subcellular fractions of these cells has now been studied. Prior to feeding, Caco-2 cells were split and cultured in human serum instead ...
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Goat anti-Pig IgG-heavy and light chain cross adsorbed Antibody Affinity Purified - 0.5 mg - Bethyl Laboratories, Inc. - antibodies
... ,A rapid test for the visual, qualitative detection of heterophile antibodies specific to infectious mononucleosis in human serum, plasma or whole blood specimens. This test is intended as an aid in the diagnosis of infectious mononucleosis in patients with characteristic clinical symptoms.,medicine,medical supply,medical supplies,medical product
ISIS Sustainable Science Audit #2. August 2000. Xenotransplantation How Bad Science and Big Business Put the World at Risk from Viral Pandemics. Dr. Mae-Wan Ho. Director. Institute of Science in Society. PO Box 32097. London NW1 0XR. UK. Summary. Xenotransplantation - the transplant of animal organs into human beings - is a multi-billion dollar business venture built on the anticipated sale of patented techniques and organs, as well as drugs to overcome organ-rejection (1). It has received strong criticism and opposition from scientists warning of risks of new viruses crossing from animal organs to human subjects and from there to infect the population at large. Our regulators, however, are adopting a permissive attitude for clinical trials to go ahead. Scientific reports of virus crossing from pig to human cells (2), and of viral infections in humans subjects transplanted with baboon livers (3), are being ignored or dismissed, while inconclusive, widely faulted papers are taken as evidence that ...
J. Krause; J. E. Herbert-Read; F. Seebacher; P. Domenici; A. D. M. Wilson; S. Marras; M. B. S. Svendsen; D. Strömborn; J. F. Steffensen; S. Krause; P. E. Viblanc; P. Couillaud; P. Bach; P. S. Sabarros; P. Zaslansky; R. H. J. M. ...
Sialic acids are prominent termini of mammalian glycoconjugates and are key binding determinants for cell-cell recog-nition lectins. Binding of the sialic acid-dependent lectin, myelin-associated glycoprotein (MAG), to nerve cells is implicated in the inhibition of nerve regeneration after injury. Therefore, blocking MAG binding to nerve cell sialoglycoconjugates might enhance nerve regeneration. Previously, we reported that certain sialoglycoconjugates bearing N-acetylneuraminic acid (NeuAc) but not N-glycolylneuraminic acid (NeuGc) support MAG binding (Collins et al., 1997a). We now report highly efficient conversion of sialic acids on living neural cells from exclusively NeuAc to predominantly NeuGc using a novel synthetic metabolic precursor, N-glycolylmannosamine pentaacetate (Man-NGc-PA). When NG108-15 neuroblastoma-glioma hybrid cells, which normally express only NeuAc (and bind to MAG), were cultured in the presence of 1 mM ManNGcPA, they expressed 80-90% of their sialic acid precursor pool as
BACKGROUND: Pulmonary xenotransplantation is currently limited by hyperacute rejection mediated in part by xenoreactive natural antibody and complement. Transgenic swine organs that express the human complement regulatory protein CD59 have demonstrat
A technique for the transfer of endothelial cells and expression of recombinant genes in vivo could allow the introduction of proteins of therapeutic value in the management of cardiovascular diseases. Porcine endothelial cells expressing recombinant beta-galactosidase from a murine amphotropic retroviral vector were introduced with a catheter into denuded iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later contained endothelial cells expressing beta-galactosidase, an indication that they were successfully implanted on the vessel wall. ...
In recent years, there have been many advances in the field of biotechnology. With these advances, have come the arguments of how this information should be used, and how ethical these new processes might be. One of these processes includes xenotransplantation. Xenotransplantation is a process in which animal organs are used for vital organ transplants to humans. This process is controversial for obvious reasons, but requires further examination. Besides just vital organs, there are many other types of transplants that can also be performed. These transplants include skin grafts, corneal transplants, and bone transplants. This is done to try to solve the worldwide problem of the shortage in human organs. The amount of organs available cannot compare to the amount of organs needed, therefore xenotransplantation is performed, and a human can receive a vital organ or other life saving material from an animal. Xenotransplantation could also be used to cure other diseases where there is a shortage of ...
251504DNAEscherichia coli 1atgttaaaaa taaaatactt attaataggt ctttcactgt cagctatgag ttcatactca 60ctagctgcag cggggcccac tctaaccaaa gaactggcat taaatgtgct ttctcctgca 120gctctggatg caacttgggc tcctcaggat aatttaacat tatccaatac tggcgtttct 180aatactttgg tgggtgtttt gactctttca aataccagta ttgatacagt tagcattgcg 240agtacaagtg tttctgatac atctaagaat ggtacagtaa cttttgcaca tgagacaaat 300aactctgcta gctttgccac caccatttca acagataatg ccaacattac gttggataaa 360aatgctggaa atacgattgt taaaactaca aatgggagtc agttgccaac taatttacca 420cttaagttta ttaccactga aggtaacgaa catttagttt caggtaatta ccgtgcaaat 480ataacaatta cttcgacaat taaa 5042168PRTEscherichia coli 2Met Leu Lys Ile Lys Tyr Leu Leu Ile Gly Leu Ser Leu Ser Ala Met1 5 10 15Ser Ser Tyr Ser Leu Ala Ala Ala Gly Pro Thr Leu Thr Lys Glu Leu 20 25 30Ala Leu Asn Val Leu Ser Pro Ala Ala Leu Asp Ala Thr Trp Ala Pro 35 40 45Gln Asp Asn Leu Thr Leu Ser Asn Thr Gly Val Ser Asn Thr Leu Val 50 55 60Gly Val Leu Thr Leu Ser Asn Thr Ser Ile Asp Thr Val Ser Ile Ala65 70 75 80Ser Thr Ser Val ...
Compare & find the top performing anti-Pig (Porcine) IL1RN antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)).
Mechanism of human lymphocyte stimulation by concanavalin A: role of valence and surface binding sites.: A monovalent form of concanavalin A (m-Con A) has been
... ,For the qualitative detection of Infectious mononucleosis IgM heterophile antibodies in human whole blood, serum and plasma specimens.,medicine,medical supply,medical supplies,medical product
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Preparations useful in the diagnosis of infectious mononucleosis are disclosed. Horse and sheep erythrocytes are purified and essentially homogenous glycoproteins are extracted. The purified glycoproteins are useful as antigens in testing for the presence of the heterophile antibodies of infectious mononucleosis and in the preparation of reagents for the enumeration of rosetting lymphocytes without having to have available fresh sheep blood.
Infectious mononucleosis in the past has signified to many physicians a mild infectious disease primarily affecting the nasopharynx and distinguishable from ordinary infections of the upper respiratory passages by striking enlargement of the lymph nodes, the appearance in the blood of large numbers of lymphocytes of characteristic bizarre type, and the development during convalescence of heterophile agglutinins for sheep red blood cells. It was early recognized, however, that many cases differ markedly in their clinical features from this classical type and that in individual cases there may be evidence of involvement of many different organs and tissues. Among these may ...
I am enjoying life, despite diabetes type 2. I am retired and enjoying the time I have for writing and photography. I was diagnosed with type 2 on Oct 2003, on oral meds for 4 months and they were doing nothing to really improve my daily readings. By cutting my carbohydrates I received the most improvement, but still not enough. Then I requested insulin, even though I did not like the thought of needles. That brought about the biggest change and A1cs in the lower 6s and upper 5s. Now I am working at maintaining them under 6.0 and hopefully nearer 5.5 ...
Xenotransplantation involves the transplantation of living cells, tissues, or organs of animal origin or of human material that has had ex vivo contact with these living, xenogeneic materials. The most pressing concern raised by clinical xenotransplantation is the risk of transmitting infectious diseases across the species barrier; then from the xeno-recipient to her close contacts (including involved health professionals) and the wider public. This chapter presents some of the key issues relating to xenotransplantation; considers the xeno-surveillance regimes suggested or implemented to date; and examines the role of the law in protecting global health in this context.
It is known that various DHP calcium antagonists enhance the NO release from endothelial cells.14 15 16 17 18 19 Using an NO-sensitive electrode, we previously demonstrated that nifedipine in the micromolar and submicromolar concentration ranges stimulates the NO release from the native endothelium.33 34 These findings were obtained after acute exposure to DHP calcium antagonists. Therefore, we investigated whether (1) a long-term treatment (48 hours, entire passage 2) of porcine endothelial cell cultures with nifedipine resulted in a similarly altered NO release and (2) an increased formation and/or an impaired inactivation of NO might be involved by measuring the ecNOS (NOS isoform III) mRNA and protein expression and the antioxidative potency of nifedipine, respectively.. In contrast to the short-term measurements during long-term treatment, nifedipine was not present in the buffer during the antioxidative and NO experiments.. We could demonstrate that treatment with nifedipine (concentration ...
The use of animals as a source of cells, tissues, and organs for transplantation - xenotransplantation - has been of increasing interest in recent years. Transplantation of animal tissues into human patients is occurring now at various centers and the possibility of organ xenotransplants is widely discussed. This new volume presents a balanced review of recent progress in understanding the immunologic aspects of xenotransplantation and zoonotic risks. It addresses how the application of various immunosuppressive modalities might compromise the immunological competence of recipients and examines the relevant issues relating to zoonotic disease. This is the first book to deal with the issues of host defense and zoonosis in xenotransplantation and points to the critical issues that must be addressed to make the process safe from the perspective of the patient and society as well as critical questions yet to be answered Valuable reading for physicians, scientists, and those engaged in the development of
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
The Diaries of Despair xenotransplantation legal battle and public interest issues - justified exposure of a horrific vivisection scandal.

Epstein-Barr Virus (EBV) Infectious Mononucleosis (Mono) Workup: Laboratory Studies, Imaging Studies, Other TestsEpstein-Barr Virus (EBV) Infectious Mononucleosis (Mono) Workup: Laboratory Studies, Imaging Studies, Other Tests

These heterophile antibodies react to antigens from animal RBCs.. * Sheep RBCs agglutinate in the presence of heterophile ... Kano K, Milgrom F. Heterophile antigens and antibodies in medicine. Curr Top Microbiol Immunol. 1977. 77:43-69. [Medline]. ... Major antibodies - Heterophile (Paul-Bunnell), EBV antigens, cold agglutinins (anti-1), smooth muscle antibodies (SMA) ... Heterophile antibody tests * Patients with infectious mononucleosis should first be tested with a heterophile antibody test. ...
more infohttps://emedicine.medscape.com/article/222040-workup

Heterophile | Definition of Heterophile by Merriam-WebsterHeterophile | Definition of Heterophile by Merriam-Webster

... or being an antibody circulating in blood serum that is reactive with antigen originating in a different species. How to use ... Share heterophile Post the Definition of heterophile to Facebook Share the Definition of heterophile on Twitter ... Rhyming Dictionary: Words that rhyme with heterophile. Comments on heterophile What made you want to look up heterophile? ... Time Traveler for heterophile The first known use of heterophile was in 1920. See more words from the same year ...
more infohttps://www.merriam-webster.com/dictionary/heterophile

HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS* | Annals of Internal Medicine | American College of PhysiciansHETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS* | Annals of Internal Medicine | American College of Physicians

The terms "heterogenetic," "heterophilic," or "heterophile" are applied to those antibodies that react with an antigen (sheep ... HETEROPHILE ANTIBODY REACTION CAUSED BY BACTERIAL INFECTION(HETEROPHILE ANTIBODY REACTION CAUSED BY BACTERIAL INFECTION*) ... HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS(HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS*) ROBERT E ... HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS(HETEROPHILE ANTIBODY REACTION IN INFECTIOUS MONONUCLEOSIS*). Ann ...
more infohttp://annals.org/aim/article-abstract/673018/heterophile-antibody-reaction-infectious-mononucleosis

Epstein Barr virus - wikidocEpstein Barr virus - wikidoc

1995). "Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1". Nature. ... Moderate-to-high levels of heterophile antibodies are seen during the first month of illness and decrease rapidly after week 4 ... EBNA-1 possesses a glycine-alanine repeat that impairs antigen processing and MHC class I-restricted antigen presentation ... EBV latent antigens. All EBV nuclear proteins are produced by alternative splicing of a transcript starting at either the Cp or ...
more infohttps://www.wikidoc.org/index.php/Epstein-Barr_virus

Epstein-Barr Virus, Infectious Mononucleosis | Quick Medical Diagnosis & Treatment Pediatrics | AccessPediatrics | McGraw-Hill...Epstein-Barr Virus, Infectious Mononucleosis | Quick Medical Diagnosis & Treatment Pediatrics | AccessPediatrics | McGraw-Hill...

Heterophile antibodies. *. Appear in over 90% of older patients with mononucleosis, but in less than 50% of children younger ... Acute EBV infection is established by detecting IgM antibody to the viral capsid antigen (VCA) or by detecting a fourfold or ...
more infohttp://accesspediatrics.mhmedical.com/content.aspx?bookid=2196§ionid=166958215

Heterophile antigen - WikipediaHeterophile antigen - Wikipedia

Heterophile antigens: certain antigens of similar nature, if not identical, present in different tissues in different ... Example: Forssman antigen, cross reacting microbial antigen so antibodies to these antigens produced by one species cross react ... hetereogenetic antigen is shared by different species. Other heterophile antigen are responsible for some diagnostic ... Therefore antibodies are produced in rabit serum by injecting antigen(antiforssman antibodies). ...
more infohttps://en.wikipedia.org/wiki/Heterophile_antigen

An antigen-binding cell tumor. Heterophile cold hemagglutinin as a me by H Hiai, H Shisa et al."An antigen-binding cell tumor. Heterophile cold hemagglutinin as a me" by H Hiai, H Shisa et al.

An antigen-binding cell tumor. Heterophile cold hemagglutinin as a membrane-bound receptor on a mouse lymphoma. ... Hiai, H; Shisa, H; Nishizuka, Y; and Miyawaki, H, "An antigen-binding cell tumor. Heterophile cold hemagglutinin as a membrane- ... Neoplasm:, Serology: Antigen, Types of Tumors:, Strains: BALB/C, C3HF (C3HB,ZB) ...
more infohttps://mouseion.jax.org/ssbb1974/975/

Heterophile - WikipediaHeterophile - Wikipedia

Heterophile antibodies are antibodies induced by external antigens (heterophile antigens). Some cross-react with self-antigens ... Heterophile antigen An immunoassay is a biochemical test, frequently used in medical diagnostic testing, that measures the ... These are considered heterophile antibodies. In clinical diagnosis, the heterophile antibody test specifically refers to a ... Heterophile antibodies can cause significant interference in any immunoassay. The presence of a heterophile antibody is ...
more infohttps://en.wikipedia.org/wiki/Heterophile

Heterogenetic antigen | Article about heterogenetic antigen by The Free DictionaryHeterogenetic antigen | Article about heterogenetic antigen by The Free Dictionary

Find out information about heterogenetic antigen. heterophile antigen Explanation of heterogenetic antigen ... heterogenetic antigen. [¦hed·ə·rō·jə¦ned·ik ′ant·i·jən] (immunology) heterophile antigen ... heterogenetic antigen. Also found in: Dictionary, Thesaurus, Medical. ... Heterogenetic antigen , Article about heterogenetic antigen by The Free Dictionary https://encyclopedia2.thefreedictionary.com/ ...
more infohttp://encyclopedia2.thefreedictionary.com/heterogenetic+antigen

Epstein-Barr Virus (EBV) Infectious Mononucleosis (Mono) MedicationEpstein-Barr Virus (EBV) Infectious Mononucleosis (Mono) Medication

Kano K, Milgrom F. Heterophile antigens and antibodies in medicine. Curr Top Microbiol Immunol. 1977. 77:43-69. [Medline]. ... The presence of heterophile antibodies in infectious mononucleosis. Am J Med Sci. 1932. 183:90-104. ... False positive heterophile tests for EBV infectious mononucleosis. Infect Dis Pract. 2001. 25:7-9. ... Relationship between antibody production to Epstein-Barr virus (EBV) early antigens and various EBV-related diseases. Springer ...
more infohttps://emedicine.medscape.com/article/222040-medication

Paul-Bunnell antigen and a possible mechanism of formation of heterophile antibodies in patients with infectious mononucleosis....Paul-Bunnell antigen and a possible mechanism of formation of heterophile antibodies in patients with infectious mononucleosis....

Paul-Bunnell antigen and a possible mechanism of formation of heterophile antibodies in patients with infectious mononucleosis ... Heterophile antigen asociated with a glycoprotein from the bovine erythrocyte membrane. Vox Sang.; 43: 57-70. ... Higashi H, Naiki M, Matuo S, Okouchi K. (1977) Antigen of serum sickness type of heterophile antibodies in human sera: ... Nakarai H, Saida T, Shibata Y, Irie RF, Kano K. (1987) Expression of heterophile, Paul-Bunnell and Hanganutziu-Deicher antigens ...
more infohttp://psjd.icm.edu.pl/psjd/element/bwmeta1.element.bwnjournal-article-abpv50i4p1205kz

Antibody | definition of Antibody by Medical dictionaryAntibody | definition of Antibody by Medical dictionary

heterogenetic antibody , heterophil antibody, heterophile antibody antibody directed against heterophile antigens. Heterophile ... Antibody produced by a particular antigen combines with that antigen only. The exquisite specificity of Ab for the antigen that ... the antigen or forming a complex to stimulate phagocytosis; promote antigen clumping (agglutination); or prevent the antigen ... Forssman antibody heterophile antibody directed against the Forssman antigen.. heteroclitic antibody antibody produced in ...
more infohttps://medical-dictionary.thefreedictionary.com/Antibody

Antispermatozoal antibody | definition of antispermatozoal antibody by Medical dictionaryAntispermatozoal antibody | definition of antispermatozoal antibody by Medical dictionary

heterogenetic antibody , heterophil antibody, heterophile antibody antibody directed against heterophile antigens. Heterophile ... Antibody produced by a particular antigen combines with that antigen only. The exquisite specificity of Ab for the antigen that ... the antigen or forming a complex to stimulate phagocytosis; promote antigen clumping (agglutination); or prevent the antigen ... Forssman antibody heterophile antibody directed against the Forssman antigen.. heteroclitic antibody antibody produced in ...
more infohttps://medical-dictionary.thefreedictionary.com/antispermatozoal+antibody

Medicine and Epidemiology
     - UC DavisMedicine and Epidemiology - UC Davis

Heterophile Antigens Biocompatible Materials View all 13 projects Research Output 1974 2019 * 2460 Article ...
more infohttps://ucdavis.pure.elsevier.com/en/organisations/medicine-and-epidemiology

Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts<...Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts<...

Thus, the goal of an antigen removal process should be to reduce the antigen content of a xenogeneic tissue while preserving ... Thus, the goal of an antigen removal process should be to reduce the antigen content of a xenogeneic tissue while preserving ... Thus, the goal of an antigen removal process should be to reduce the antigen content of a xenogeneic tissue while preserving ... Thus, the goal of an antigen removal process should be to reduce the antigen content of a xenogeneic tissue while preserving ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/antigen-removal-for-the-production-of-biomechanically-functional-

Augustin, L. B.<...Augustin, L. B.<...

Fingerprint The Fingerprint is created by mining the titles and abstracts of the persons research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri. ...
more infohttps://experts.umn.edu/en/persons/lance-b-augustin

Christopher Burlak - Research Output
     - Experts@MinnesotaChristopher Burlak - Research Output - [email protected]

Wang, W., Nguyen, L. T. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., Ju, S., Fisher, O. S., Miller, D. W., Datta, D., Wu, F., Wu, C. X., Landeru, A., Wells, J. A., Cookson, M. R., Boxer, M. B., Thomas, C. J., Gai, W. P., Ringe, D., Petsko, G. A. & 1 others, Hoang, Q. Q., Aug 23 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 34, p. 9587-9592 6 p.. Research output: Contribution to journal › Article ...
more infohttps://experts.umn.edu/en/persons/christopher-burlak/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

Heterophil antibody synonyms, heterophil antibody antonyms - FreeThesaurus.comHeterophil antibody synonyms, heterophil antibody antonyms - FreeThesaurus.com

2 synonyms for heterophil antibody: Forssman antibody, heterophile antibody. What are synonyms for heterophil antibody? ... Related to heterophil antibody: heterophile antigen. #vtZoom,.vt-link{cursor:pointer} .vt-container{padding:5px 6px 0 0;border- ... heterophile antibody,type:2},{name:antibody,type:4}]},/script, ,svg width=720px height=600px id=vtSvg viewBox=0 ... heterophil antigen, heterogenetic antigen. *heterophil antigen, heterogenetic antigen. *heterophil antigen, heterogenetic ...
more infohttps://www.freethesaurus.com/heterophil+antibody

The immunoassay kit directory. Series B, Infectious diseases. Volume 1, part 3, Enteric and other infections : December 1995 ...The immunoassay kit directory. Series B, Infectious diseases. Volume 1, part 3, Enteric and other infections : December 1995 ...

Heterophile antigen.- Antibody detection.- See also Multipathogen Assays section under: Infectious Mononucleosis Syndrome Test ... Antigen detection.- Clostridium difficile (toxin A).- Antigen detection.- Clostridium difficile (toxin A and toxin B).- Antigen ... Antigen detection.- Antigen detection.- H. influenzae, N. meningitidis, S. agalactiae, S. pneumoniae.- Antigen detection.- TECH ... Antigen detection.- E. coli (enterotoxin, LT) and V. cholerae (enterotoxin, CT).- Antigen detection.- Salmonella species and ...
more infohttps://www.worldcat.org/title/immunoassay-kit-directory-series-b-infectious-diseases-volume-1-part-3-enteric-and-other-infections-december-1995/oclc/851388161

Utilization of autopsy RNA for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus...Utilization of autopsy RNA for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus...

These data demonstrate that even in the absence of a virus isolate, the necessary homologous antigen can be produced and can ... These data demonstrate that even in the absence of a virus isolate, the necessary homologous antigen can be produced and can ... These data demonstrate that even in the absence of a virus isolate, the necessary homologous antigen can be produced and can ... These data demonstrate that even in the absence of a virus isolate, the necessary homologous antigen can be produced and can ...
more infohttps://researchexperts.utmb.edu/en/publications/utilization-of-autopsy-rna-for-the-synthesis-of-the-nucleocapsid-

Antigenic characterization of ehrlichiae: Protein immunoblotting of Ehrlichia canis, Ehrlichia sennetsu, and Ehrlichia risticii...Antigenic characterization of ehrlichiae: Protein immunoblotting of Ehrlichia canis, Ehrlichia sennetsu, and Ehrlichia risticii...

Heterophile Antigens Centers for Disease Control and Prevention (U.S.) Sodium Dodecyl Sulfate ... Little is known about the antigens of the ehrlichiae. This report expands the breadth of available knowledge concerning the ... Little is known about the antigens of the ehrlichiae. This report expands the breadth of available knowledge concerning the ... Little is known about the antigens of the ehrlichiae. This report expands the breadth of available knowledge concerning the ...
more infohttps://researchexperts.utmb.edu/en/publications/antigenic-characterization-of-ehrlichiae-protein-immunoblotting-o

Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice<...Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice<...

TY - JOUR. T1 - Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice. AU - Zhao, Yong. AU - Xiong, Wanfen. AU - Yang, Tianyu. AU - Prall, Amy. AU - Baxter, Bernard Timothy. AU - Langnas, Alan Norman. PY - 2003/5/1. Y1 - 2003/5/1. N2 - Background: The cellular infiltrate in xenografts suggests that macrophages may be involved in xenograft rejection. However, the precise role of macrophages in xenograft rejection has not yet been fully addressed. Methods: Xenogeneic rat skin grafts were transplanted to macrophage colony, stimulating factor (M-CSF)/macrophage-deficient osteopetrotic ([OP]-/-) and wild-type control mice. Skin graft survival and antidonor rat humoral responses were quantified. Results: Xenogeneic rat skin grafts survived 13 days in wild-type control mice, survival of rat skin grafts was significantly prolonged to 24 days in [OP]-/- mice (P , 0.01). Similar results were observed in sensitized [OP]-/- and control mouse recipients, showing markedly prolonged ...
more infohttps://nebraska.pure.elsevier.com/en/publications/xenogeneic-skin-graft-rejection-in-m-csfmacrophage-deficient-oste

Preparation, quality criteria, and properties of human blood platelet lysate supplements for ex vivo stem cell expansion<...Preparation, quality criteria, and properties of human blood platelet lysate supplements for ex vivo stem cell expansion<...

However, FBS has a poorly characterized composition and poses risk factors, as it may be a source of xenogenic antigens and ... However, FBS has a poorly characterized composition and poses risk factors, as it may be a source of xenogenic antigens and ... However, FBS has a poorly characterized composition and poses risk factors, as it may be a source of xenogenic antigens and ... However, FBS has a poorly characterized composition and poses risk factors, as it may be a source of xenogenic antigens and ...
more infohttps://tmu.pure.elsevier.com/en/publications/preparation-quality-criteria-and-properties-of-human-blood-platel

MEDICAMEDICA

antigens, heterophile (2). *aprotinin (2). *brachyura (2). *bradykinin (2). *dietary proteins (2) ...
more infohttp://digital.library.musc.edu/cdm/search/searchterm/untreated
  • Merrick JM, Zadarlik K, Milgrom F. (1978) Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing N-glycolyl-neuraminic acid. (edu.pl)
  • Furthermore, when serum samples obtained from 10 patients who were convalescing from ehrlichiosis were tested against each antigen, only three serum samples had any reactivities, and these serum samples reacted with only a few of the antigenic bands. (utmb.edu)
  • Evidence is presented that the corresponding antigen of bovine erythrocytes is not, as previously described, a single molecule, but a series of glycoproteins with glycans terminated with N-glycolylneuraminic acid (Neu5Gc). (edu.pl)
  • This finding confirms a previous report that human erythrocyte Neu5Ac containing sialoglycoprotein with similar O-linked glycans as the PB-antigen of bovine erythrocytes exhibits only very low PB activity (Patarca & Fletcher, 1995, Crit Rev Oncogen. (edu.pl)
  • Heterophile antigen asociated with a glycoprotein from the bovine erythrocyte membrane. (edu.pl)
  • Merrick JM, Schifferle R, Zadarlik K, Kano K, Milgrom F. (1977) Isolation and partial characterization of the heterophile antigen of infectious mononucleosis from bovine erythrocytes. (edu.pl)
  • This report expands the breadth of available knowledge concerning the antigenic components and serologic responses to component antigens of E. canis, E. sennetsu, and E. risticii. (utmb.edu)
  • These results document the molecular sizes of electrophoretically separated antigens of the three Ehrlichia species, confirm their serologic relationships, and support the novel nature of the agent(s) of human ehrlichiosis in the United States. (utmb.edu)
  • These changes allow considering some gangliosides as tumor-associated antigens and they have been selected as possible target for active and passive immunotherapy [ 9 , 10 ]. (hindawi.com)
  • Virus isolation attempts have been unsuccessful thus far, resulting in a lack of homologous antigen for use in diagnostic assays. (utmb.edu)
  • For this reason, a molecular approach was initiated to produce recombinant homologous antigen. (utmb.edu)
  • These data demonstrate that even in the absence of a virus isolate, the necessary homologous antigen can be produced and can serve to improve the detection and diagnostic capabilities needed to combat this newly recognized fatal respiratory illness in the United States. (utmb.edu)
  • B. Process for analysis which involve an in vitro antigen-antibody, immunological or protein binding interaction other than those involving a living antigen, or enzyme label. (uspto.gov)
  • i. induction of l-glutamic acid60-l-alanine30-l-tyrosine10 specific suppressor t cells in vitro requires both antigen-specific t-cell-suppressor factor and antigen. (liverpool.ac.uk)
  • N protein-expressing Hela cells served as excellent antigens for an improved indirect immunofluorescence assay. (utmb.edu)
  • The heterophile test is less useful in children younger than 2 years, in whom the results are frequently negative. (medscape.com)
  • The latter compound should be an important part of the PB epitope because, in agreement with the results of others, we found that desialylation of the PB antigen abolishes almost completely its activity. (edu.pl)
  • EBV nuclear antigen (EBNA) appears after 1-2 months and persists throughout life. (medscape.com)