A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The relationships of groups of organisms as reflected by their genetic makeup.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
An order of insects comprising three suborders: Anisoptera, Zygoptera, and Anisozygoptera. They consist of dragonflies and damselflies.
A discipline or occupation concerned with the study of INSECTS, including the biology and the control of insects.
Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
Activities performed to identify concepts and aspects of published information and research reports.
A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
A malignant disease of the B-LYMPHOCYTES in the bone marrow and/or blood.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
A general term for various neoplastic diseases of the lymphoid tissue.
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
A species of POLYOMAVIRUS suspected to be the cause of most cases of MERKEL CELL CARCINOMA, a rare but highly lethal form of skin cancer.
A basic-leucine zipper transcription factor that is closely related to C-FOS PROTEINS. It forms heterodimeric complexes with C-JUN PROTEINS to regulate GENE transcription.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Substances which lower blood glucose levels.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

Novel regulation of the homeotic gene Scr associated with a crustacean leg-to-maxilliped appendage transformation. (1/4207)

Homeotic genes are known to be involved in patterning morphological structures along the antero-posterior axis of insects and vertebrates. Because of their important roles in development, changes in the function and expression patterns of homeotic genes may have played a major role in the evolution of different body plans. For example, it has been proposed that during the evolution of several crustacean lineages, changes in the expression patterns of the homeotic genes Ultrabithorax and abdominal-A have played a role in transformation of the anterior thoracic appendages into mouthparts termed maxillipeds. This homeotic-like transformation is recapitulated at the late stages of the direct embryonic development of the crustacean Porcellio scaber (Oniscidea, Isopoda). Interestingly, this morphological change is associated with apparent novelties both in the transcriptional and post-transcriptional regulation of the Porcellio scaber ortholog of the Drosophila homeotic gene, Sex combs reduced (Scr). Specifically, we find that Scr mRNA is present in the second maxillary segment and the first pair of thoracic legs (T1) in early embryos, whereas protein accumulates only in the second maxillae. In later stages, however, high levels of SCR appear in the T1 legs, which correlates temporally with the transformation of these appendages into maxillipeds. Our observations provide further insight into the process of the homeotic leg-to-maxilliped transformation in the evolution of crustaceans and suggest a novel regulatory mechanism for this process in this group of arthropods.  (+info)

Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. (2/4207)

In order to identify molecular mechanisms involved in striatal development, we employed a subtraction cloning strategy to enrich for genes expressed in the lateral versus the medial ganglionic eminence. Using this approach, the homeobox gene Meis2 was found highly expressed in the lateral ganglionic eminence and developing striatum. Since Meis2 has recently been shown to be upregulated by retinoic acid in P19 EC cells (Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Sapin, V., Chambon, P. and Dolle, P. (1997) Dev. Dyn. 210, 173-183), we examined a potential role for retinoids in striatal development. Our results demonstrate that the lateral ganglionic eminence, unlike its medial counterpart or the adjacent cerebral cortex, is a localized source of retinoids. Interestingly, glia (likely radial glia) in the lateral ganglionic eminence appear to be a major source of retinoids. Thus, as lateral ganglionic eminence cells migrate along radial glial fibers into the developing striatum, retinoids from these glial cells could exert an effect on striatal neuron differentiation. Indeed, the treatment of lateral ganglionic eminence cells with retinoic acid or agonists for the retinoic acid receptors or retinoid X receptors, specifically enhances their striatal neuron characteristics. These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation.  (+info)

Purification and characterization of ADP-ribosyl cyclase from Euglena gracilis. (3/4207)

ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with a molecular mass of 40 kDa. Its Km value for NAD+ was estimated to be 0.4 mM, and cADPR, a product of the enzyme, inhibited the enzyme competitively with respect to NAD+ whereas another product, nicotinamide, showed noncompetitive (mixed-type) inhibition. In contrast to mammalian CD38 and BST-1, Euglena ADP-ribosyl cyclase lacked cADPR hydrolase activity.  (+info)

The CTLA-4 gene is expressed in placental fibroblasts. (4/4207)

In order to elucidate the mechanisms that ensure survival of the allogeneic fetus, we are investigating the expression pattern of genes that are involved in peripheral self-tolerance in tissues at the maternal-fetal interface. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a negative regulator of T cell activation and may modulate peripheral self-tolerance. Previously, we reported the preferential transmission of maternally-inherited shorter alleles at a 3'-UTR microsatellite locus to liveborn children, but random transmission of paternally-inherited alleles, suggesting that CTLA-4 may be involved in the maintenance of tolerance at the maternal-fetal interface. In this report, we demonstrate that CTLA-4 mRNA and protein are indeed expressed in fetal tissues at the maternal-fetal interface throughout gestation.  (+info)

Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. (5/4207)

Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d1 as 0.47/day and d2 as 0.04/day. Interpatient differences in both decay rates were significant. The d1 was directly correlated with baseline CD4+, CD4+CD28+, and CD8+CD28+ T lymphocyte counts (P<.05) and inversely correlated with baseline virus load (P=.044) and the magnitude of CD4+ and CD8+ T lymphocyte recovery (P<.01). The d2 was directly correlated with baseline percentage of CD8+ T lymphocytes (P=.023), the CD8+CD38+ cell number (P=.024), and the level of IgG that binds to human immunodeficiency virus (HIV) type 1 gp120 (P=.02). Viral decay rates were not predictive of treatment failure or durability of viral suppression. These exploratory findings are consistent with a model in which immunologic factors contribute to elimination of HIV-infected cells and suggest a dynamic interplay between regulation of HIV expression and lymphocyte activation and recovery.  (+info)

Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. (6/4207)

To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to +info)

Cellular and molecular characterization of the scurfy mouse mutant. (7/4207)

Mice hemizygous (Xsf/Y) for the X-linked mutation scurfy (sf) develop a severe and rapidly fatal lymphoproliferative disease mediated by CD4+CD8- T lymphocytes. We have undertaken phenotypic and functional studies to more accurately identify the immunologic pathway(s) affected by this important mutation. Flow cytometric analyses of lymphoid cell populations reveal that scurfy syndrome is characterized by changes in several phenotypic parameters, including an increase in Mac-1+ cells and a decrease in B220+ cells, changes that may result from the production of extremely high levels of the cytokine granulocyte-macrophage CSF by scurfy T cells. Scurfy T cells also exhibit strong up-regulation of cell surface Ags indicative of in vivo activation, including CD69, CD25, CD80, and CD86. Both scurfy and normal T cells are responsive to two distinct signals provided by the TCR and by ligation of CD28; scurfy cells, however, are hyperresponsive to TCR ligation and exhibit a decreased requirement for costimulation through CD28 relative to normal controls. This hypersensitivity may result, in part, from increased costimulation through B7-1 and B7-2, whose expression is up-regulated on scurfy T cells. Although the specific defect leading to this hyperactivation has not been identified, we also demonstrate that scurfy T cells are less sensitive than normal controls to inhibitors of tyrosine kinases such as genistein and herbimycin A, and the immunosuppressant cyclosporin A. One interpretation of our data would suggest that the scurfy mutation results in a defect, which interferes with the normal down-regulation of T cell activation.  (+info)

IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes. (8/4207)

Mouse B cells express CD38, whose ligation by anti-CD38 Ab induces their proliferation and protection from apoptosis. We previously showed that stimulation of mouse splenic B cells with IL-5 together with CS/2, an anti-mouse CD38 mAb, induces production of IgG1 and IgM. Here we examined the role of IL-5 and CS/2 in the expression of germline gamma1 transcripts and the generation of reciprocal products forming DNA circles as byproducts of mu-gamma1 switch recombination. By itself, CS/2 induced significant expression of germline gamma1 transcripts in splenic naive B cells, whereas IL-5 neither induced nor enhanced germline gamma1 expression. Increased cellular content of reciprocal product, which is characteristic of mu-gamma1 recombination, was not observed after culturing B cells with CS/2, but increased reciprocal product, along with high levels of lgG1 secretion, was found when B cells were cultured with CS/2 plus IL-5. Although IL-4 did not, by itself, induce mu-gamma1 recombination in B cells stimulated with CS/2, in conjunction with CS/2 plus IL-5, IL-4 dramatically enhanced sterile gamma1 transcription and IgG1 production. These results demonstrate that CD38 ligation induces only germline gamma1 transcription and that IL-5 promotes both mu-gamma1 switch recombination and lgG1 secretion in an IL-4-independent manner.  (+info)

The remarkable functional plasticity of professional antigen-presenting cells (APCs) allows the adaptive immune system to respond specifically to an incredibly diverse array of potential pathogenic insults; nonetheless, the specific molecular effectors and mechanisms that underpin this plasticity re …
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Background: Associations between polymorphisms in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) / interleukin-18 (IL-18) and susceptibility to liver diseases were already reported by many publications. The aim of this meta-analysis was to clarify associations between polymorphisms in CTLA-4/IL-18 and liver diseases by combing the results of all relevant publications. Methods: Eligible publications were searched from Pubmed, Embase, WOS and CNKI. The latest literature searching update was performed on 2nd October, 2019. We used Review Manager to combine the results of individual studies. Results: Sixty-seven studies were included in this study. Combined results revealed that CTLA-4 rs231775 (dominant comparison: OR 0.83, 95 % CI 0.79-0.88; recessive comparison: OR 1.33, 95 % CI 1.23-1.43; allele comparison: OR 0.84, 95 % CI 0.78-0.90), IL-18 rs1946518 (dominant comparison: OR 0.85, 95 % CI 0.78-0.92; recessive comparison: OR 1.29, 95 % CI 1.13-1.48; allele comparison: OR 0.79, 95 % CI ...
The emergence of immune checkpoint inhibitors for solid tumor treatments represents a major oncological advance. Since the approval of ipilimumab, a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibody, for the treatment of metastatic melanoma, many drugs, especially those targeting PD1/PD-L1, have demonstrated promising antitumor effects in many types of cancer. By reactivating the immune system (IS), these immunotherapies have led to the development of new toxicity profiles, also called immune-related adverse events (irAEs). IrAEs can involve many organ systems, and their management is radically different from that of cytotoxic drugs; irAEs require immunosuppressive treatments, such as corticoids or tumor necrosis factor alpha (TNFα) antibody. Additionally, the occurrence of irAEs has raised significant questions. Here, we summarize progress that has been made toward answering these questions, focusing on 1) the impact of immunotherapy dose on irAE occurrence, 2) the correlation ...
Researchers have found that sometimes the body’s own immune system may slow down or control cancer growth. Sometimes this natural immune system response stops, and the cancer is not killed by the immune system. Research has shown that, in some patients, cancer cells and immune cells start to express signals that stop the body’s immune system from killing the cancer. New drugs being developed are designed to block these signals and to increase the immune response. Durvalumab and tremelimumab are two of these drugs. Both drugs are antibodies (proteins that are produced by the body’s defense system). Durvalumab given by itself or with tremelimumab may boost the ability of your immune system to detect and fight cancer. Each of these drugs targets a different signal. Durvalumab targets a signal on cancer cells called Programmed Cell Death Ligand 1 (PD-L1) and tremelimumab targets a signal on immune cells called Cytotoxic T-Lymphocyte-associated Antigen 4 (CTLA-4). It is hoped that ...
Immunotherapy encompasses both vaccines that direct immune responses to tumor-associated antigens, and checkpoint blocking antibodies that inhibit immune system suppression by targeting key pathways mediated by cytotoxic T-lymphocyte-associated antigen 4, programmed death 1 (PD-1), and programmed de …
Abstract Download Blockade of various immune targets such as cytotoxic T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated tumor regression and immune-related adverse events, predominantly gastrointestinal events including diarrhea and colitis. The current review is done to understand the […]. ...
Human Cell Differentiation Molecules is an organisation which runs HLDA (Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules.
Human Cell Differentiation Molecules is an organisation which runs HLDA (Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules.
Two closely related proteins, signal regulatory protein α (SIRPα; SHPS-1/CD172) and SIRPβ, have been described in humans. The existence of a third SIRP protein has been suggested by cDNA sequence only. We show that this third SIRP is a separate gene that is expressed as a protein with unique characteristics from both α and β genes and suggest that this gene should be termed SIRPγ. We have expressed the extracellular region of SIRPγ as a soluble protein and have shown that, like SIRPα, it binds CD47, but with a lower affinity (K d , ∼23 μM) compared with SIRPα (K d , ∼2 μM). mAbs specific to SIRPγ show that it was not expressed on myeloid cells, in contrast to SIRPα and -β, being expressed instead on the majority of T cells and a proportion of B cells. The short cytoplasmic tail of SIRPγ does not contain any known signaling motifs, nor does it contain a characteristic lysine, as with SIRPα, that is required for DAP12 interaction. DAP12 coexpression is a requirement for SIRPβ surface
Our findings support the hypothesis that T cell activation is a critical and proximal event in the complex chronic inflammatory cascade that culminates in the generation of psoriatic plaques. To our knowledge, this is the first report documenting the accumulation of mature DCs in a human autoimmune target organ, the skin. Additionally, the resolution of activated phenotypes on lesional keratinocytes, DCs, and vascular endothelium after T cell costimulatory blockade has not previously been reported. Thus, these data expand upon our prior observations (15) and provide possible mechanisms for the observed durable reduction in intralesional T cells after administration of CTLA4Ig. We have demonstrated that a reduced capacity for lesional T cell clonal expansion (due to reversion of the lesional skin APC population to a less mature/immunocompetent state) and decreased vascular recruitment may both have been contributory factors. These observations suggest that clinical activity in this chronic ...
This phase I clinical investigation was undertaken in an effort to obtain a preliminary assessment of the biologic activity and toxicity of MDX-CTLA-4 in previously vaccinated metastatic melanoma and ovarian carcinoma patients. The study was motivated by compelling preclinical data indicating that the combination of CTLA-4 antibody blockade and cancer vaccination stimulated greater levels of antitumor immunity than either approach alone. Because the combination treatment also provoked a loss of tolerance to normal differentiation antigens, the risk of serious toxicities to patients was of some concern. Hence, we initially elected to administer CTLA-4 antibody blockade to previously vaccinated cancer patients.. Our initial results suggest that a single infusion of MDX-CTLA-4 may be safely delivered in this clinical setting. The generation of low titers of autoantibodies shows that the therapy may at least partially compromise systemic tolerance, but no evidence for autoimmune disease was noted. ...
This phase I clinical investigation was undertaken in an effort to obtain a preliminary assessment of the biologic activity and toxicity of MDX-CTLA-4 in previously vaccinated metastatic melanoma and ovarian carcinoma patients. The study was motivated by compelling preclinical data indicating that the combination of CTLA-4 antibody blockade and cancer vaccination stimulated greater levels of antitumor immunity than either approach alone. Because the combination treatment also provoked a loss of tolerance to normal differentiation antigens, the risk of serious toxicities to patients was of some concern. Hence, we initially elected to administer CTLA-4 antibody blockade to previously vaccinated cancer patients.. Our initial results suggest that a single infusion of MDX-CTLA-4 may be safely delivered in this clinical setting. The generation of low titers of autoantibodies shows that the therapy may at least partially compromise systemic tolerance, but no evidence for autoimmune disease was noted. ...
The combined results show that the efficacy of therapeutic vaccination against experimental melanoma is markedly increased by interfering with mechanisms that normally keep autoimmune responses in check. Antitumor treatment is strongly improved if vaccination is either accompanied by CTLA-4 blockade or preceded by a depletion of CD25+ Treg cells. These intervention strategies act synergistically, in that combination of CTLA-4 blockade and depletion of CD25+ Treg cells results in maximal efficacy of therapeutic vaccination. The potency of the different treatment modalities for preventing B16 melanoma outgrowth strongly correlates with the extent of autoimmune skin depigmentation in the treated mice as well as with the frequency of TRP-2180-188-specific CTLs detected in the periphery. Furthermore, antitumor protection was abrogated upon depletion of the CD8+ T cell subset. Therefore, our data indicate that the CTL response against melanoma-associated autoantigens is an important component of the ...
Clone REA479 recognizes the human CD172g antigen, a single-pass type I membrane protein also known as signal-regulatory protein γ (SIRPγ) or signal-regulatory protein β 2 (SIRPβ2). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. CD172g is the only member of the SIRP family that is expressed on T cells, some B cells, CD56bright natural killer (NK) cells, and all activated NK cells. CD172g does bind CD47, albeit with less affinity than CD172a (SIRPα). This interaction mediates cell-cell adhesion, rather than inhibitory signals. The adhesion mediated by contact of CD172g on T cells with CD47 on antigen-presenting cells (APCs) promotes antigen-specific T cell proliferation and costimulates T cell activation.Additional information: Clone REA479
A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.
Interaction of signal regulatory protein (SIRP) expressed on the surface of macrophages with its ligand CD47 expressed on target cells negatively regulates phagocytosis of the latter cells by the former. We recently showed that blocking Abs to mouse SIRP enhanced both the Ab-dependent cellular phagocytosis (ADCP) activity of mouse macrophages for Burkitts lymphoma Raji cells opsonized with an Ab to CD20 (rituximab) invitro as well as the inhibitory effect of rituximab on the growth of tumors formed by Raji cells in nonobese diabetic (NOD)/SCID mice. However, the effects of blocking Abs to human SIRP in preclinical cancer models have remained unclear given that such Abs have failed to interact with endogenous SIRP expressed on macrophages of immunodeficient mice. With the use of Rag2(c)(-/-)(-/-) mice harboring a transgene for human SIRP under the control of human regulatory elements (hSIRP-DKO mice), we here show that a blocking Ab to human SIRP significantly enhanced the ADCP activity of ...
Within the paradigm of the two-signal model of lymphocyte activation, the interest in costimulation has witnessed a remarkable emergence in the past few years with the discovery of a large array of molecules that can serve this role, including some with an inhibitory function. Interest has been further enhanced by the realization of these molecules potential as targets to modulate clinical immune responses. Although the therapeutic translation of mechanistic knowledge in costimulatory molecules has been relatively straightforward, the capacity to target their inhibitory counterparts has remained limited. This limited capacity is particularly apparent in the case of the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a major negative regulator of T cell responses. Because there have been several previous comprehensive reviews on the function of this molecule, we focus here on the physiological implications of its structural features. Such an exercise may ultimately help us to design
The monoclonal antibody UC10-4B9 reacts with CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a costimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152. - Liechtenstein
Cancer immunotherapy relies on the ability of the immune system to target tumor specific antigens to generate an immune response. This initial response requires both binding of the MHC/antigen peptide to T-cell receptor complex along with a second co-stimulatory signal created by the binding of CD28 on the T cell with B7 located on the antigen presenting cell. Regulatory checkpoints, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), serve to attenuate this signal, thereby preventing autoimmunity. Its key role in regulating the immune system has made CTLA-4 an attractive therapeutic target for cancer, with the development of fully human monoclonal antibodies that have successfully targeted CTLA-4 in clinical trials. Augmentation of the immune response via blockade of CTLA-4 represents a significant advance in the field of oncology and has demonstrated an improvement in survival for patients with metastatic melanoma. An increased understanding of the components of this pathway and the ...
This medicine is human anti-CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) monoclonal antibody. It binds to CTLA-4 receptor of T-cell (immune cell) to enhance growth/activation/cytotoxic activity of tumor antigen-specific T-cell. It consequently suppresses tumor growth. It also decreases regulatory T-cell (Treg) function and reduces the number of Treg in the tumor tissue. It consequently increases anti-tumor immune response and suppresses tumor growth ...
CTLA-4 (Cytotoxic T-lymphocyte-associated protein 4, CD152) protein. CTLA4 blocking antibodies are used in cancer therapy (immune checkpoint blockade therapy). Space-filling model with conventional colour coding. - Stock Image F019/2238
A high mutational load and the presence of a T-cell-inflamed environment may independently predict for treatment response to pembrolizumab (Keytruda) and progression-free survival, according to a study presented by Tanguy Seiwert, MD, of the University of Chicago, at the 2017 ASCO-SITC Clinical Immuno-Oncology Symposium.1. Nonsynonymous mutational load and neoantigen load as well as an 18-gene immune-related gene-expression profiling were significantly associated with overall response and progression-free survival to pembrolizumab across multiple indications, Dr. Seiwert revealed. This suggests that tumor antigenicity and T-cell infiltration may provide complementary information for expected pembrolizumab activity and may be useful in characterizing responses to immunotherapies, he said.. Tumor mutational load has been shown to correlate with benefit from drugs blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) in multiple tumor types. ...
Hereditary Factors:, Linkage:, Origin:, Serology: Antigen, Congenic Resistant Lines: A.SW, Genes: Ly-3 - Lymphocyte antigen-3, Lyt-3, Ly-1 - Lymphocyte antigen-1, ly-a, Lyt-1, mu - greek, Ly-2 - Lymphocyte antigen-2, Lyt-2, Strains: A(CAL-A) (A/J), AKR, BALB/C, CBA/H-T6T6, CE, C3H/AN, C3H/BI, C3HF (C3HB, ZB), C57BL/6, C57BL/10, C57BR/CD, C58, DA, DBA/2 (212), GR, H-2I (HTI), H-2H (HTH), I, L (P), LP, NZB, PL (PLA, PLB), RF (W), SJL, ST/B (STB), SWR, 129. ...
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SIRP alpha小鼠多克隆抗体(ab77061)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
The HuGEMM CTLA-4 mouse model is a chimeric tumor model where the mouse immune system is functional and the CTLA-4 receptors have been humanized
High-quality CTLA-4 proteins from ACROBiosystems. Various species and tags of PCSK9 proteins. Minimal Batch-to-Batch Variation. Bulks in stock.
a prospective study of 30 patients suffering from IBD referred from tropical department from Tanta University Hospital. -Patients demographic data e.g., sex, age, concomitant systemic diseases will be recruited. Presenting symptoms, physical examination results, laboratory and imaging findings, and received treatment of IBD will be recorded. Accurate grading of disease severity will be carried out by gastroenterology specialist.. All patients will be subject to Full ophthalmologic examination and fundus imaging. Imaging will include OCTA and fundus photography. OCTA will be performed using cirrus OCT (Zeiss, Inc., USA). High-quality 6 x 6 mm OCTA macular scans and 3 × 3-mm papillary scan with strong signal-noise ratio and adequate centration on the fovea and optic nerve head respectively will be selected. Segmentation will be used to evaluate super﫿cial and deep capillary retinal plexus projections in addition to the choriocapillaries. If errors in segmentation were detected, manual ...
Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 A resolution. These data, together with previous data on the N-terminal domain and its ligand CD47 (possessing a single immunoglobulin superfamily domain), show that the CD47-SIRPalpha interaction will span a distance of around 14 nm between interacting cells, comparable with that of an immunological synapse. The N-terminal (V-set) domain mediates binding to CD47, and the two others are found to be constant (C1-set) domains. C1-set domains are restricted to proteins involved in vertebrate antigen recognition: T cell antigen receptors, immunoglobulins, major histocompatibility complex antigens, tapasin, and beta2-microglobulin. The domains of SIRPalpha (domains 2 and 3) are structurally more similar to
Prior therapy with any antibody/drug that targets the T cell coregulatory proteins, including but not limited to, anti-CD137, Anti Cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA4) or Anti-Glucocorticoid-induced tumor necrosis factor receptor (anti-GITR). However, Anti-Programmed Death-1 (anti-PD-1), Anti-Programmed Death-Ligand1 (anti-PD-L1) are permissible as prior ...
Complete information for SIRPA gene (Protein Coding), Signal Regulatory Protein Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The P84 monoclonal antibody reacts with Signal-Regulatory Protein α (SIRPα), also known as CD172a. SIRPα is a type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells. Neurons and other tissues of the central nervous system have also been shown to express SIRPα. Its ligand, CD47 is expressed by a wide variety of cells. SIRPα and CD47 regulate dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis. SIRPα diffuses laterally on the macrophage membrane and accumulates at a phagocytic synapse to bind CD47 which inhibits phagocytosis by macrophages. Anti-SIRPα antibodies that block the interaction of SIRPα with CD47 have been shown to suppress tumor formation in mice. The P84 antibody has been shown to have neutralizing activity in vivo and in vitro ...
B cell development is a highly organized process, which commences in the fetal liver during embryogenesis and in the bone marrow (BM) after birth. Surface IgM+ immature B cells emigrate from the BM via the blood stream to the spleen and finally differentiate into conventional mature follicular B (FoB) cells and marginal zone (MZ) B cells. Conversely, some sIgM+ immature B cells can also mature into IgD+ FoB cells in the BM.. The ubiquitously expressed cell surface glycoprotein CD47 and its receptor signal regulatory protein α (SIRPα) are members of the immunoglobulin superfamily. Both individually and upon their interaction, CD47 and SIRPα have been found to play important role in the homeostasis of T lymphocytes or CD8- conventional dendritic cells (cDCs) in secondary lymphoid organs. However, their role in regulating B cell homeostasis has remained unknown.. The present study describes important roles of CD47 and SIRPα in B cell homeostasis. Lack of SIRPα signaling in adult SIRPα mutant ...
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy. Indeed, modulating immune inhibitory pathways has been considered an important breakthrough in cancer treatment. Although immune checkpoint blockade therapy used to treat malignant diseases has provided promising results, both solid and haematological malignancies develop mechanisms that enable themselves to evade the host immune system. To overcome some major limitations and ensure safety in patients, recent strategies have shown that combining epigenetic modulators, such as inhibitors of histone deacetylases (HDACi) or DNA methyltransferases (DNMTi), with immunotherapeutics can be useful. Preclinical data generated using mouse models strongly support the feasibility and effectiveness of the proposed approaches. Indeed, co-treatment with pan- or class I-selective HDACi or
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors are becoming a cornerstone of cancer immunotherapy as a result of their clinical success in relieving immune suppression and driving durable antitumor T cell responses in certain subsets of patients. Unfortunately, checkpoint inhibition is also associated with treatment-related toxicities that result in a myriad of side effects, ranging from mild and manageable to severe and debilitating. In this issue of the JCI, Das and colleagues report an association between early therapy-induced changes in circulating B cells and an increased risk of high-grade immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors that target cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and programmed cell death protein 1 (PD1). These findings identify potential predictive biomarkers for high-grade IRAEs that may be leveraged to improve patient monitoring and may prompt new treatment strategies to prevent IRAEs.. ...
Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown durable treatment...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
Design of efficacious Treg-based therapies and establishment of clinical tolerance in autoimmune diseases have proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments related to the stability and isolation procedures of Tregs as well as the specific in vivo targets of Treg modalities. Herein, we have demonstrated that Foxp3+ Tregs potently suppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated protein 4-dependent (CTLA4-dependent) manner. Autophagy-deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4+ T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted activation of the PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs, leading to decreased transcription of the autophagy component microtubule-associated protein 1 light chain 3β (Lc3b). Human DCs treated with CTLA4-Ig, a fusion protein ...
GZMB - GZMB (untagged)-Human granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (GZMB) available for purchase from OriGene - Your Gene Company.
TEL :. +86 153 6067 3248 (Intl). US Toll free: 855 777 3210 EU Toll free: 800 3272 9252 Korea Toll free: 001 800 3272 9252 (Telecom ...
Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and adaptive immune responses. Unlike CD47, which is expressed ubiquitously, SIRPα expression is mainly restricted to myeloid cells and neurons. Therefore, compared to CD47-targeted therapies, targeting SIRPα may result in differential safety and efficacy profiles, potentially enabling lower effective doses and improved pharmacokinetics and pharmacodynamics. The development of effective SIRPα antagonists is restricted by polymorphisms within the CD47-binding domain of SIRPα, necessitating pan-allele reactive anti-SIRPα antibodies for therapeutic intervention in diverse patient populations. We immunized wild-type and human antibody transgenic chickens with a multi-allele and multi-species SIRPα regimen in order to discover pan-allelic and pan-mammalian reactive anti-SIRPα antibodies suitable for clinical translation. A total of ...
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as Cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer.
Reaktivität: Rind (Kuh), Pferd, Human and more. 68 verschiedene SIRPG Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
CD172a (SIRP alpha), FITC, clone: 15-414, eBioscience™ 25 Tests; FITC CD172a (SIRP alpha), FITC, clone: 15-414, eBioscience™ Primary Antibodies CD151 to CD200
Gentaur molecular products has all kinds of products like :search , FabGennix \ T-Lymphocyte antigen 4, Host species: rabbit, polyclonal antibody \ CTLA4-101AP for more molecular products just contact us
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a dont eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well ...
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells.
SIRPB1 - SIRPB1 (untagged)-Human signal-regulatory protein beta 1 (SIRPB1), transcript variant 2 available for purchase from OriGene - Your Gene Company.
T4/Leu-3, B4, CVID3, T3, CD3ε, FcγRIII, Integrin αX subunit, CR4, p150, ITGAX, Leu-19, NKH1, Monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein, LPS receptor, T8, Leu2, Leukocyte Common Antigen (LCA), T200 ...
White Cell Differentiation Antigens: 654-55. Loken MR, Shah VO, Civin CI (1987). "Characterization of myeloid antigens on human ... White Cell Differentiation Antigens. pp. 630-35. "Stemcells Redirection". stemcells.nih.gov. Bhatia M, Bonnet D, Murdoch B, Gan ... hematopoietic cell surface antigen defined by a monoclonal antibody raised against KG-1a cells". Journal of Immunology. 133 (1 ... Many markers belong to the cluster of differentiation series, like: CD34, CD38, CD90, CD133, CD105, CD45, and also c-kit - the ...
The most common dyes act by binding to antigens presented on cells. Common antigens targeted are clusters of differentiation ( ... When a CD73+ antigen expressed itself with RCVRN+ cells (calcium-binding proteins in the eye), it showed researchers that this ... "Human CD & Other Cellular Antigens - US". www.thermofisher.com. Retrieved 2018-12-11. "MACS" (website). Miltenyi Biotech. ... antigens).This is a column based separation technique where labeled cells are passed through a magnetic column. Magnetic beads ...
Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, ... phagocytosis and antigen presentation. Phagocytosis is the main process of macrophages and antigen presentation the main ... Their main activity is antigen presentation; they express Factor XIIIa, CD1c, and Class II Human leukocyte antigens. A subset ... They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T helper cells). These histiocytes ...
They found that the immune responses to innocuous antigens triggers an increase in the activity of hypothalamic neurons and ... Affect cell growth, proliferation and differentiation. Cause immunosuppression which can lead to an extended amount of time ... Suppress cell adhesion, antigen presentation, chemotaxis and cytotoxicity. Increase apoptosis. Release of corticotropin- ...
JL1, a novel differentiation antigen of human cortical thymocyte. J Exp Med. 178:1447-51, 1993 Choi EY, Park WS, Jung KC, Chung ... He also found the novel antigen JL1 on thymocytes, which has been developed as a therapeutic target for leukemia. Today he is ... He also found the novel antigen JL1 expressed in thymocytes (J Exp Med. 178:1447-51, 1993). JL1 is a unique epitope of CD43 ... Another important achievement of his research is the induction of antigen-specific T cell tolerance, which has been a distant ...
Cole, Leon J.; Cumley, Russell W. (1942). "Differentiation of Old and New World Species of the Genus Columba". The American ... Irwin, M. R.; Cole, Leon J. (September 1945). "Immunogenetic Studies of Cellular Antigens: Individual Differences between ...
The FLT3 gene codes for the cluster of differentiation antigen 135 (i.e. CD135) protein or FLT3 protein. This protein is a ... It mediates at least in part the cell proliferating signaling stimulated by PDGF receptors as well as by antigen receptors on T ... PDGFRA, through its tyrosine kinase activity, contributes to the growth, differentiation, and proliferation of cells. ... PDGFRA, through its tyrosine kinase activity, contributes to the growth, differentiation, and proliferation of cells. ...
It binds to a specific antigen to initiate an immune response. T-cell antibodies bind to antigens such as virus infected cells ... This rearrangement occurs early in the differentiation process and creates novel T-cell receptors that mimic the structure of ... Once this antigen is lost, the T-cell antibodies will never be able to detect the pathogen, allowing the pathogen to increase ... In Lutzner cells, there is a mutation in the T-cell receptor that inhibits antigens like CD8 and CD7, but stimulates the over ...
... (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting ... CD1+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature. 341 (6241): 447-50. ... CD1 antigens are expressed on cortical thymocytes, but not on mature T cells. This often remains true in neoplastic cells from ...
... differentiation antigens of rat lymphocytes". Cell. 12: 696-703. doi:10.1016/0092-8674(77)90266-5. Thomas ML, Barclay AN, ... Thomas ML, Barclay AN, Gagnon J, Williams AF (1985). "Evidence from cDNA clones that the rat leukocyte-common antigen (T200) ... Gagnon J, Williams AF (1985). "Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T ...
"MACROPHAGE ANTIGEN CD68; CD68". omim.org. Retrieved 16 September 2017. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M ... CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes ... Other names or aliases for this gene in humans and other animals include: CD68 Molecule, CD68 Antigen, GP110, Macrosialin, ... Cluster of differentiation Lysosome-associated membrane glycoprotein Scavenger receptor (immunology) GRCh38: Ensembl release 89 ...
May 2003). "Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the ... CK19, Cytokeratin 19, K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT ... Ning H, Lin G, Lue TF, Lin CS (December 2006). "Neuron-like differentiation of adipose tissue-derived stromal cells and ... Anzai H, Nagayoshi M, Obata M, Ikawa Y, Atsumi T (February 1999). "Self-renewal and differentiation of a basic fibroblast ...
... stimulate the differentiation and proliferation of, and present foreign antigens to B-cells. The FD cells in FDCS may derive ... The EBV+ NK cells express CD56 antigen and are malignant with EBV in its latency II phase. The NK cells expression relatively ... Addition of rituximab, a monoclonal antibody against the CD20 antigen expressed on B cells, may be added to this or other ... The EBV+ large B cells in these lesions often have reduced expression of the CD20 antigen and contain genetic abnormalities ...
Each well of a microtitre plate is coated with either a single antigen or multiple antigens to detect specific antibodies or to ... large protein complexes in the nucleus that may have a role in cell growth and differentiation. Anti-PM-Scl antibodies are ... known as extractable nuclear antigens (ENAs). This led to the characterisation of ENA antigens and their respective antibodies ... The antigen of anti-dsDNA antibodies is double stranded DNA. Anti-histone antibodies are found in the serum of up to 75-95% of ...
17%); pPCL plasma cells often lack CD56 antigen which is present on the majority of plasma cells taken form multiple myeloma ... particularly Cluster of differentiation. CD markers on plasma cells from patients with pPCL differ from those taken form ... For example: pPCL plasma cells more often express CD20 antigen, which is considered important in anchoring plasma cells to the ... Examination of plasma cell immunophenotype by measuring certain of their cell surface antigens, ...
Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000171124 - Ensembl, May 2017 "Human PubMed Reference:". National ... CD174+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH). ... Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced ... The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial ...
May 2012). "Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues". Journal ... TRM cells develop from circulating effector memory T cell precursors in response to antigen. The main role in formation of TRM ...
MHC II with bound antigen is then transported to the plasma membrane for presentation. CLIP also can affect the differentiation ... CLIP is one of the most prevalent self peptides found in the thymic cortex of most antigen-presenting cells. The purpose of ... Conformational Plasticity in Antigen Presentation". Frontiers in Immunology. Frontiers. 8: 292. doi:10.3389/fimmu.2017.00292. ...
... which allows for differentiation between strains of viruses through their distinct antigens. The other four tests detect group ... a chicken class II major histocompatibility complex antigen), and T and B-lymphocytes were observed to determine its effects on ... antigens. Maternal antibodies have displayed protection against the development of microscopic lesions of tenosynovitis in ...
A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74. A33 is more ... 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci ... 2004). "Human leukocyte antigen-A, -B, and -Cw polymorphism in a Berber population from North Morocco using sequence-based ... B14 splits into B64 (B*1401) and B65 (B*1402) but the only Arabian people which show both antigens are the United Arab Emirates ...
However, it has been suggested that Th17 can also play a more major role in osteoclast differentiation via cell to cell contact ... These cytokines are produced by activated antigen presenting cells (APCs) after contact with pathogens. The Th17 cells can ... Thus, active form of vitamin D is a direct inhibitor for Th17 differentiation. In this way, oral administration of vitamin D3 ... In an SIV-rhesus monkey model, it was found that administering IL-21, a cytokine shown to encourage Th17 differentiation and ...
A69 is a split antigen of the broad antigen serotype A28. A69 is a sister serotype of A68. A69 is more common in Levant. A69 (A ... 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci ... Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in ... HLA-A69 (A69) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ...
They prevent differentiation of monocytes to dendritic cells. Tumor microvesicles also carry tumor antigen, so they can be an ... CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... This mechanism of action can be used in processes such as antigen presentation, where MHC molecules on the surface of ... For example, those released from antigen-presenting cells (APCs), such as B cells and dendritic cells, are enriched in proteins ...
Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. ... "Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes". ... She developed an in vitro model to assess monocyte differentiation into dendritic cells (DCs) or macrophages. They found that ... Sinai, her lab explored monocyte fate and differentiation, and their trafficking out of inflamed tissues through lymphatic ...
IL-10 suppresses Th1 cells differentiation and function of dendritic cells. Th2 overactivation against antigen will cause Type ... For example, when an antigen-presenting cell displays a peptide antigen on MHC class II proteins, a CD4+ cell will aid those ... During an immune response, professional antigen-presenting cells (APCs) endocytose antigens (typically bacteria or viruses), ... that a host antigen is foreign. As a result, the CD8+ T cells treat the host cell presenting that antigen as infected, and go ...
Neuronal Nuclei antigen (NeuN) or Fox-3 is a nuclear protein present in postmitotic cell, at the point of differentiation into ... All of these antigens are present in specific neuronal cell types. With these we can define anatomical circuits with a high ... Once a stem cell divides asymmetrically, the more mature progenitor is born and migrates to regions of differentiation. As the ... It can be expressed in glial cells during oligodendrocyte differentiation with the same levels that have been found in neuron ...
Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The efferent phase: activation, proliferation, differentiation and migration of effector cells. *The effector phase: target ... The T cells produce an excess of cytokines, including TNF-α and interferon-gamma (IFNγ). A wide range of host antigens can ... Roncarolo, Maria-Grazia; Battaglia, Manuela (August 2007). "Regulatory T-cell immunotherapy for tolerance to self antigens and ...
... of leiomyosarcoma and liposarcoma cells leads to increased expression of smooth muscle and adipocyte differentiation antigens, ...
Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... "Joint Report of the First International Workshop on Human Leucocyte Differentiation Antigens by the Investigators of the ... T cell differentiation. • cell surface receptor signaling pathway. • positive regulation of T cell proliferation. • positive ...
... received from the T cell during differentiation.[6] Differentiation through a T cell-independent antigen stimulation ( ... Surface antigens[edit]. Terminally differentiated plasma cells express relatively few surface antigens, and do not express ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ...
Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection (PDF). ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proceedings of the National ... An induced rebinding model of antigen discrimination. Trends Immunol. 2014, 35 (4): 153-8. PMC 3989030. PMID 24636916. doi: ... Williams, Matthew A.; Bevan, Michael J. Effector and memory CTL differentiation. Annual Review of Immunology. 2007, 25: 171-192 ...
CD20 is widely expressed on B cells, from early pre-B cells to later in differentiation, but it is absent on terminally ... It increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen). ...
Pays, E. (2005). "Regulation of antigen gene expression in Trypanosoma brucei". Trends Parasitol. 21 (11): 517-20. doi:10.1016/ ... has evolved so many copies of its major surface antigen that about 10% of its genome is devoted to different versions of this ... Gamete differentiation/sexes. *Life cycles/nuclear phases. *Mating types. *Meiosis. *Sex-determination ...
Mesenchyme is a type of connective tissue found in developing organs of embryos that is capable of differentiation into all ... providing the ground for starting inflammatory and immune responses upon the detection of antigens.[15]:161 ...
The cytotoxicity of Natural Killer (NK) cells and the antigen-presenting function of dendritic cells is known to diminish with ... "Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice ... The age-associated impairment of dendritic Antigen Presenting Cells (APCs) has profound implications as this translates into a ... Hakim, F.T.; R.E. Gress (2007). "Immunosenescence: deficits in adaptive immunity in elderly". Tissue Antigens. 70 (3): 179-189 ...
These cells bind antigens presented on MHC I complex of virus-infected or tumour cells and kill them. Nearly all nucleated ... cellular differentiation lineage).[6] Lymphocytes can be further classified as T cells, B cells, and natural killer cells. ... Basophils are chiefly responsible for allergic and antigen response by releasing the chemical histamine causing the dilation of ... Dendritic cells (Although these will often migrate to local lymph nodes upon ingesting antigens) ...
... due to an aPL-induced inhibition of trophoblast differentiation. The antiphospholipid syndrome responsible for most of the ... that use recombinant antigens will not have a false-positive result. ...
MHC complex on a professional antigen-presenting cell and by the B7:CD28 costimulatory signal. Upon activation, "low-affinity" ... altering the behavior or differentiation of nearby cells. Intracrine Local hormone Endocrine system Pandit, Nikita K. (2007). ...
Białko p21 (WAF1) jest w stanie oddziaływać z jądrowym antygenem komórek proliferujących (proliferating cell nuclear antigen − ... Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1). „Proc. Natl. Acad. ... Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. „J. ... Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. „J. Biol. Chem.". ...
TI-1 antigens have an intrinsic B cell activating activity, that can directly cause proliferation and differentiation of B ... TI-2 antigen[edit]. Second group of TI antigens consists mainly of highly repetitive surface structures (epitopes) of ... TI-1 antigen, which has an activity that can directly activate B cells and TI-2 antigen, which has highly repetitive structure ... It results in proliferation and differentiation of B lymphocytes and production of antibodies. TI-2 antigens can activate only ...
Lee YJ، Luisiri P، Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and ... "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function" ...
Affected individuals with KS and other forms of HH are almost invariably born with normal sexual differentiation; i.e., they ... haematocrit and prostate-specific antigen (PSA). If injections are used, trough levels are taken to ensure an adequate level of ...
Peptide antigens are displayed by the major histocompatibility complex class I (MHC) proteins on the surface of antigen- ... Interview by CDD". Cell Death and Differentiation. 12 (9): 1167-77. doi:10.1038/sj.cdd.4401691. PMID 16094393.. ... Interview by CDD". Cell Death and Differentiation. 12 (9): 1158-61. doi:10.1038/sj.cdd.4401709. PMID 16094391.. ... Interview by CDD". Cell Death and Differentiation. 12 (9): 1167-77. doi:10.1038/sj.cdd.4401691. PMID 16094393.. ...
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
"Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation" ... Goodpasture-antigen-binding protein kinase (EC 2.7.11.9). *-. IκB kinase (EC 2.7.11.10). *CHUK ...
negative regulation of fat cell differentiation. • negative regulation of myoblast differentiation. • positive regulation of ... "Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism". J. Exp. Med ... regulation of osteoclast differentiation. • defense response to bacterium. • positive regulation of interleukin-6 production. • ... osteoclast differentiation. • regulation of tumor necrosis factor-mediated signaling pathway. • positive regulation of cytokine ...
A wide range of studies has been conducted investigating the role in cell proliferation, differentiation, death, and survival.[ ... "Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in ... cluster of differentiation 230).[5][6][7][8] Expression of the protein is most predominant in the nervous system but occurs in ... Some research indicates PrP involvement in neuronal development, differentiation, and neurite outgrowth. The PrP-activated ...
CD8 (cluster of differentiation 8) adalah glikoprotein transmembran yang berfungsi sebagai ko-reseptor untuk reseptor sel T. ... Human CD Antigen Chart. *CD8 alpha - Marker for cytotoxic T lymphocytes [1] ...
Binding of antigens to IgE already bound by the FcεRI on mast cells causes cross-linking of the bound IgE and the aggregation ... The B lymphocyte differentiation and maturation pathway that eventually generate IgE-secreting plasma cells go through the ... FcεRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells in both mice and humans. ... IgE also plays a pivotal role in responses to allergens, such as: anaphylactic drugs, bee stings, and antigen preparations used ...
One example of an epigenetic change in eukaryotic biology is the process of cellular differentiation. During morphogenesis, ... has a 10-40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA).[51] ... This determines differences in gene expression and cell differentiation. It has been shown that at least some nucleosomes are ... Waddington suggested visualising increasing irreversibility of cell type differentiation as ridges rising between the valleys ...
Proteins: clusters of differentiation (see also list of human clusters of differentiation) ... Macrophage-1 antigen (CD11b+CD18). *VLA-4 (CD49d+CD29). *Glycoprotein IIb/IIIa (ITGA2B+ITGB3) ...
Antibodies are protein components of an adaptive immune system whose main function is to bind antigens, or foreign substances ... "Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue-specific intervention possible?". ... Ribbon diagram of a mouse antibody against cholera that binds a carbohydrate antigen ...
Prostate specific membrane antigen is a transmembrane carboxypeptidase and exhibits folate hydrolase activity.[75] This protein ... Chuang AY, DeMarzo AM, Veltri RW, Sharma RB, Bieberich CJ, Epstein JI (August 2007). "Immunohistochemical differentiation of ... Prostate cancer screening is controversial.[1][3] Prostate-specific antigen (PSA) testing increases cancer detection but does ... Although the widespread use of prostate-specific antigen (PSA) screening in the US has resulted in diagnosis at earlier age and ...
positive regulation of natural killer cell differentiation. • regulation of T cell differentiation. • positive regulation of ... Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated ... natural killer cell differentiation. • positive regulation of natural killer cell proliferation. • cell-cell signaling. • ... "The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host ...
Lancefield group C and G carbohydrate antigens are predominantly expressed, but group A and L have been documented. However, ... Lancefield, R. C. (1933-03-31). "A SEROLOGICAL DIFFERENTIATION OF HUMAN AND OTHER GROUPS OF HEMOLYTIC STREPTOCOCCI". The ... Lancefield, R. C.; Hare, R. (1935-02-28). "THE SEROLOGICAL DIFFERENTIATION OF PATHOGENIC AND NON-PATHOGENIC STRAINS OF ... Unlike Streptococcus pyogenes (harbouring Lancefield group A antigen), S.dysgalactiae is PYR-negative and Bacitracin resistant ...
GalNAc and α-D-GalNAc-Ser/Thr (Tn-antigen) WFA Wisteria floribunda vistárie mnohokvětá koncové GalNAc (např. β-D-GalNAc-(1-4)- ... "O-acetylated sialic acid as a distinct marker for differentiation between several leukemia erythrocytes."; Sen G, Chowdhury M, ... β-D-Gal-(1-3)-α-D-GalNAc-Ser/Thr (T-antigen) ...
The differentiation of these stem cells from pluripotent hematopoietic stem cell into granulocytes is termed granulopoiesis. ... they are professional antigen-presenting cells, they regulate other immune cell functions (e.g., CD4+ T cell, dendritic cell, B ... Multiple intermediate cell types exist in this differentiation process, including myeloblasts and promyelocytes. ...
Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors" ... These genes play important roles in cellular development, proliferation, and differentiation.[6][4][2] Individually, most of ... TdT is a protein expressed early in the development of pre-T and pre-B cells, whereas CALLA is an antigen found in 80% of ALL ... Chimeric antigen receptors (CARs) have been developed as a promising immunotherapy for ALL. This technology uses a single chain ...
Membrane molecules as differentiation antigens of murine macrophages.. McKnight AJ1, Gordon S. ...
Stern P (1984) Differentiation antigens of teratomas and embryos. Brit Medical Bulletin 40: 218-223.Google Scholar ... Feizi T (1981) Carbohydrate differentiation antigens. Trends Biochem. Sci. 11: 333-335.CrossRefGoogle Scholar ... Dodd J. (1986) The Identification and Function of Differentiation Antigens on Primary Sensory Neurons. In: Fink G., Harmar A.J ... Jessell TM and Dodd J (1984) Structure and expression of differentiation antigens on functional subsets of primary sensory ...
Expression of normal monocyte-macrophage differentiation antigens on HL-60 promyelocytes undergoing differentiation induced by ... Dimitriu-Bona, A., Burmester, G. R., Waters, S. J., and Winchester, R. J., 1981, Lineage and differentiation antigens on human ... Griffin, J. D., Ritz, J., Nadler, L. M., and Schlossman, S. F., 1981, Expression of myeloid differentiation antigens on normal ... Todd, R. F., Van Agthoven, A., Schlossman, S. F., and Terhorst, C., 1982, Structural analysis of differentiation antigens Mo1 ...
... antigen. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions. ... Definition: an antigen (marker) on the surface of a cell, usually a lymphocyte. ...
MNDA myeloid cell nuclear differentiation antigen [Homo sapiens] MNDA myeloid cell nuclear differentiation antigen [Homo ... myeloid cell nuclear differentiation antigenprovided by HGNC. Primary source. HGNC:HGNC:7183 See related. Ensembl: ... Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the ... Title: Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the ...
... unequal distribution of antigen in dividing B lymphocytes may influence their differentiation. ... M. L. Dustin, M. Meyer-Hermann, Antigen feast or famine. Science 335, 408-409 (2012). [Abstract] [Full Text] ... Antigen acquired by B lymphocytes exhibited a polarized distribution that was sustained over several rounds of cell division. ... T lymphocytes, in turn, provide key differentiation signals to B lymphocytes. To learn more about this process, Thaunat et al. ...
Antigens, Differentiation, T Lymphocyte. Antigens expressed on the Cell Membrane of T-Lymphocytes during differentiation, ...
Differentiation, Myelomonocytic" by people in Harvard Catalyst Profiles by year, and whether "Antigens, Differentiation, ... Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of ... "Antigens, Differentiation, Myelomonocytic" is a descriptor in the National Library of Medicines controlled vocabulary ... Below are the most recent publications written about "Antigens, Differentiation, Myelomonocytic" by people in Profiles. ...
CD69 Association with Jak3/Stat5 Proteins Regulates Th17 Cell Differentiation Pilar Martín, Manuel Gómez, Amalia Lamana, ...
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. K Chang ... Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers ... Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers ... Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers ...
Monocyte differentiation antigen CD14UniRule annotation. Automatic assertion according to rulesi ... Monocyte differentiation antigen CD14Sequence analysis. Automatic assertion according to rulesi ... tr,A0A2K5LKS5,A0A2K5LKS5_CERAT Monocyte differentiation antigen CD14 OS=Cercocebus atys OX=9531 GN=CD14 PE=4 SV=1 ...
The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). ... sp,P10810,CD14_MOUSE Monocyte differentiation antigen CD14 OS=Mus musculus OX=10090 GN=Cd14 PE=1 SV=1 ... Monocyte differentiation antigen CD14Add BLAST. 321. ,p>This subsection of the ,a href="http://www.uniprot.org/help/ptm_ ... The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). ...
Relationship between AgNOR Proteins, Ki-67 Antigen, p53 Immunophenotype and Differentiation Markers in Archival Breast ... sex steroid receptor status and histopathological differentiation grade in serial paraffin sections from 39 breast carcinomas. ...
Transcriptional Profiling of Antigen-Dependent Murine B Cell Differentiation and Memory Formation. Deepta Bhattacharya, Ming T ... Transcriptional Profiling of Antigen-Dependent Murine B Cell Differentiation and Memory Formation ... Transcriptional Profiling of Antigen-Dependent Murine B Cell Differentiation and Memory Formation ... Transcriptional Profiling of Antigen-Dependent Murine B Cell Differentiation and Memory Formation ...
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Mandy L ... Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation ...
... in T cells was regulated by pathogens and the T cell antigen receptor (TCR). T cells responded to antigen by upregulating e … ... of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation Nat ... in T cells was regulated by pathogens and the T cell antigen receptor (TCR). T cells responded to antigen by upregulating ... Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and did not undergo clonal expansion or ...
Mage-b4, a Novel Melanoma Antigen (MAGE) Gene Specifically Expressed during Germ Cell Differentiation. Christina Österlund, ... Mage-b4, a Novel Melanoma Antigen (MAGE) Gene Specifically Expressed during Germ Cell Differentiation ... Mage-b4, a Novel Melanoma Antigen (MAGE) Gene Specifically Expressed during Germ Cell Differentiation ... Mage-b4, a Novel Melanoma Antigen (MAGE) Gene Specifically Expressed during Germ Cell Differentiation ...
What is cluster-of-differentiation antigen? Meaning of cluster-of-differentiation antigen as a finance term. What does cluster- ... Definition of cluster-of-differentiation antigen in the Financial Dictionary - by Free online English dictionary and ... Related to cluster-of-differentiation antigen: cluster of differentiation 4 CD (1). See: Certificate of deposit ... Cluster-of-differentiation antigen financial definition of cluster-of-differentiation antigen https://financial-dictionary. ...
Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in ... Their transfer did not increase the infarct size of Rag1 knock-out mice, indicating antigen-dependent activation as an ... Our findings underscore the importance of antigen-dependent, direct cytotoxic immune responses in stroke and suggest modulation ... direct cytotoxic effects of invading immune cells on the ischemic brain and the importance of their antigen-dependent ...
... effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen.. P ... effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen. ... effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen. ... effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen. ...
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.. P G ... A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. ... A first antigen recognized by such CTL clones was previously shown to be encoded by the tyrosinase gene. We report here the ... identification of another gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that ...
We studied the B-cell differentiation antigens CD19 and CD20, because these molecules play a critical role in the development, ... Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy ... Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy ... Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy ...
This work explores signal pathways regulated by polyomavirus small T antigen (PyST) that control differentiation and regulate ... Comparisons of the Polyomavirus Small T Antigens Demonstrate Novel Regulatory Pathways in Apoptosis and DIfferentiation.. Hwang ... Small Ts regulate differentiation through Akt. PyST inhibited Akt and its effect on differentiation was reversed by the ... Akt is an important signal regulator in differentiation. Blocking Akt activity inhibited differentiation, while activating Akt ...
The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors ... The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors ... The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors ... The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors ...
The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-lymphocyte ... The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-lymphocytes and ... CD20 (Cluster of differentiation 20, Membrane-spanning 4-domains subfamily A member 1 (MS4A1), CVID5, B-lymphocyte surface ... Home » Antibody News » CD20 (Cluster of differentiation 20, Membrane-spanning 4-domains subfamily A member 1 (MS4A1), CVID5, B- ...
The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells ...
Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells ... Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells ... Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells ... Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells ...
Cluster of Differentiation Antigen 20) Positive Lymphoma and Mantle Cell Lymphoma ... Clinical Trial: Rituximab Maintenance Therapy in Aggressive CD20 (Cluster of Differentiation Antigen 20) Positive Lymphoma and ... Clinical Trial: Rituximab Maintenance Therapy in Aggressive CD20 (Cluster of Differentiation Antigen 20) Positive Lymphoma and ...
... differentiation of antibodies to human immunodeficiency virus 1 and 2 with a strip-based assay including recombinant antigens ... Confirmation and differentiation of antibodies to human immunodeficiency virus 1 and 2 with a strip-based assay including ... Confirmation and differentiation of antibodies to human immunodeficiency virus 1 and 2 with a strip-based assay including ... recombinant antigens and synthetic peptides.. D E Pollet, E L Saman, D C Peeters, H M Warmenbol, L M Heyndrickx, C J Wouters, G ...
  • Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. (sigmaaldrich.com)
  • The CD antigens / Cluster of differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. (sinobiological.com)
  • CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies. (sinobiological.com)
  • In our body, the Cluster of Differentiation (Cluster of Designation or CD) is a protocol used for the identification and investigation of cell surface molecules present on our cells, providing targets for immunophenotyping of cells, encode by a large family of genes ( CD gene family . (wellnessadvocate.com)
  • The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. (wikipedia.org)
  • Kannagi R, Levery SB, Ishigami F, Hakomori SI, Shevinsky LH, Knowles BB and Solter D (1983a) New globoseries glycolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen: stage specific antigen 3. (springer.com)
  • The cell surface antigen recognized by monoclonal antibody SB-10 is expressed on human MSCs but is lost during their developmental progression into differentiated phenotypes. (ovid.com)
  • We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. (uni-regensburg.de)
  • Recognition of a human T-lymphocyte differentiation antigen by an IgM monoclonal antibody. (ox.ac.uk)
  • Amplification of Human B Cell Activation by a Monoclonal Antibody to the B Cell-Specific Antigen CD22, Bp 130/140," J. Immunol. (freepatentsonline.com)
  • an antigen (marker) on the surface of a cell, usually a lymphocyte. (drugs.com)
  • Because cues received through T lymphocyte interactions are likely to influence B lymphocyte fate decisions, unequal distribution of antigen in dividing B lymphocytes may influence their differentiation. (sciencemag.org)
  • Antigen distribution across activated B cells influences B-T lymphocyte interactions. (sciencemag.org)
  • It functions as a B-cell activation receptor and B-lymphocyte development and differentiation agent, presumably through modulating intracellular calcium levels. (novusbio.com)
  • One such human B cell marker is the human B lymphocyte-restricted differentiation antigen Bp35, referred to as "CD20. (justia.com)
  • Inflammatory reactions are believed to be triggered by innate signals and have a major protective role by recruiting innate immunity cells, favoring lymphocyte activation and differentiation, and thus contributing to the sequestration and elimination of the injurious stimuli. (frontiersin.org)
  • While testing their CTL activity (by co-injecting them with antigen-loaded and non-loaded targets directly into the spleen), these effectors did not kill loaded targets, but rather induced the local retention of both antigen-loaded and non-loaded targets ( 2 ), mimicking the events described in non-specific phase of lymphocyte trapping ( 3 - 5 ). (frontiersin.org)
  • Indeed, during the first 2-4 days of an immune response all antigen-specific-cells dispersed throughout the body are retained in the restricted site where the antigen is first presented (a phenomenon named lymphocyte trapping). (frontiersin.org)
  • Several polymorphic DNA restriction endonuclease fragments hybridizing with xenotropic and ecotropic envelope virus probes map adjacent to minor histocompatibility and lymphocyte (H/Ly) antigen-encoding loci. (scripps.edu)
  • On and in our body's cells, CD26 Antigen (Dipeptidyl Peptidase 4) , as a T-lymphocyte differentiation antigen member. (wellnessadvocate.com)
  • Structural Characterization of the Human B Lymphocyte-Restricted Differentiation Antigen CD22," J. Immunol. (freepatentsonline.com)
  • The expression of these same antigens also increased in conjunction with monocytoid differentiation when HL-60 cells were treated with supernatants from leukocytes stimulated with phytohemagglutinin (PHA-LCM) or with mixed lymphocyte conditioned medium (MLC). (ashpublications.org)
  • The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. (nih.gov)
  • Value of Quantitative assessment of Myeloid Nuclear Differentiation Antigen expression and other flow cytometric parameters in the diagnosis of Myelodysplastic syndrome. (nih.gov)
  • Flow cytometry in the diagnosis of myelodysplastic syndromes and the value of myeloid nuclear differentiation antigen. (nih.gov)
  • Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma. (nih.gov)
  • Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). (nih.gov)
  • MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. (genecards.org)
  • Stage-specific embryonic antigens (SSEA-3 and SSEA-4) are epitopes of a unique globoseries ganglioside isolated from human teratocarcinoma cells. (springer.com)
  • Knowles BB, Rappaport J and Solter D (1982) Murine embryonic antigen SSEA-1 is expressed on human cells and structurally related human blood group antigen I is expressed on mouse embryos. (springer.com)
  • Daughter cells that received more antigen were better able to stimulate T cells. (sciencemag.org)
  • Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. (harvard.edu)
  • When the cDNA was transfected into COS and NIH 3T3 cells, the antigen was found on the cell surface and could be released by treatment with phosphatidylinositol-specific phospholipase C. The 69-kDa precursor is processed to the 40-kDa form. (pnas.org)
  • Here we show that the intracellular supply of large neutral amino acids (LNAAs) in T cells was regulated by pathogens and the T cell antigen receptor (TCR). (nih.gov)
  • T cells responded to antigen by upregulating expression of many amino-acid transporters, but a single System L ('leucine-preferring system') transporter, Slc7a5, mediated uptake of LNAAs in activated T cells. (nih.gov)
  • Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and did not undergo clonal expansion or effector differentiation. (nih.gov)
  • Although deleterious effects of proinflammatory cytokines are well characterized, direct cytotoxic effects of invading immune cells on the ischemic brain and the importance of their antigen-dependent activation are essentially unknown. (sigmaaldrich.com)
  • These cells were HLA-A*0201 specific and lytic for peptide-loaded antigen-presenting cells but not to malignant or unpulsed B cells. (aacrjournals.org)
  • CD19 and CD20 play an important role in the development, differentiation, and activation of B cells. (aacrjournals.org)
  • The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-lymphocytes and B-lymphocytes at all stages of maturation (except for plasma cells). (novusbio.com)
  • To identify novel genes that potentially mediate the effects of TZDs, we have isolated genes that are differentially expressed during thiazolidinedione-stimulated differentiation of 3T3-L1 cells. (aspetjournals.org)
  • Using mRNA differential display, we have compared 3T3-L1 cells treated to differentiate in the presence of BRL49653 with untreated 3T3-L1 cells and identified Fos-related antigen 1 (Fra-1), a member of the Fos protein family, as a novel molecular target for BRL49653 action in 3T3-L1 cells. (aspetjournals.org)
  • The CD antigens are protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. (sinobiological.com)
  • Non peptide antigen presentation to T-cell receptors on NKT cells. (sinobiological.com)
  • Treg cell differentiation started within 2 days and with Foxp3+ cells in the most divided population, demonstrating that peripheral Treg cell generation can be the dominant outcome from naïve T cell activation. (wustl.edu)
  • Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females. (pubfacts.com)
  • Therefore, we generated LysM-Cre Runx1(fl/fl) mice, which delete Runx1 equally (∼80% deletion) in myeloid precursor cells from both sexes and examined the capacity of these cells to differentiate into osteoclasts and phagocytic and antigen-presenting cells. (pubfacts.com)
  • We also demonstrated that loss of Runx1 in pluripotential myeloid precursors with LysM-Cre did not alter the number of myeloid precursor cells in bone marrow or their ability to differentiate into phagocytizing or antigen-presenting cells. (pubfacts.com)
  • Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. (elsevier.com)
  • Our first aim addresses the role of CD4+ and B cells n suppressing tumor immunity and memory responses, particularly to different action: antigens. (grantome.com)
  • such activation causes release of biological mediators ("interleukins") which, in essence, stimulate B cells to differentiate and produce antibody ("immunoglobulins") against the antigen. (justia.com)
  • T cells and B cells both comprise cell surface proteins which can be utilized as "markers" for differentiation and identification. (justia.com)
  • Specifically, the CD20 molecule may regulate a step in the activation process which is required for cell cycle initiation and differentiation and is usually expressed at very high levels on neoplastic ("tumor") B cells. (justia.com)
  • In essence, such targeting can be generalized as follows: antibodies specific to the CD20 surface antigen of B cells are, eg injected into a patient. (justia.com)
  • the anti-CD20 antibody bound to the CD20 surface antigen may lead to the destruction and depletion of neoplastic B cells. (justia.com)
  • Recent studies suggested that this local retention was due to the formation of stable interactions between antigen-specific T cells and the antigen-presenting cells (APCs). (frontiersin.org)
  • These stable interactions would lead to T cell activation and the subsequent down-regulation of the sphingosine-1-phosphate (S1P) receptor S1P 1 at the T cell surface, preventing antigen-specific T cells to egress the lymphoid organ ( 6 ). (frontiersin.org)
  • However, these events only explain why antigen-specific-cells remain in contact with the APCs presenting the antigen. (frontiersin.org)
  • In these circumstances, some circulating antigen-specific-cells may fail to contact these rare APCs, unless their transit time through the draining lymph node (DLNs) is considerably modified. (frontiersin.org)
  • How chemotherapy-induced cell death leads to efficient antigen presentation to T cells, however, remains a conundrum. (cf.ac.uk)
  • ATP released by dying cancer cells recruited myeloid cells into tumors and stimulated the local differentiation of CD11c+CD11b+Ly6Chi cells. (cf.ac.uk)
  • Such cells efficiently engulfed tumor antigens in situ and presented them to T lymphocytes, thus vaccinating mice, upon adoptive transfer, against a challenge with cancer cells. (cf.ac.uk)
  • Our results identify a subset of tumor-infiltrating leukocytes as therapy-relevant antigen-presenting cells. (cf.ac.uk)
  • At the periphery, Cdc42-deficient naive T cells displayed an impaired actin polymerization and TCR clustering during the formation of mature immunological synapse, and showed an enhanced differentiation to Th1 and CD8 + effector and memory cells in vitro and in vivo. (plos.org)
  • The differentiation of DN thymocytes to CD4 + CD8 + double-positive (DP) cells is dependent on the expression and rearrangement of TCRβ and TCRα. (plos.org)
  • Upon recognition of peptide-MHC complex on antigen-presenting cells (APC), naïve T cells undergo actin cytoskeletal rearrangement, TCR clustering, and formation of immunological synapse (IS). (plos.org)
  • These cellular events elicit a cascade of intracellular signaling changes including activation of ZAP70 and LAT and subsequent ERK, JNK and p38 MAP kinases, leading to naïve T cell clonal expansion and differentiation into effector and memory cells [2] . (plos.org)
  • In our body's cells, the human gene DPP4 gene (CD26 gene) molecule encodes for the dipeptidyl-peptidase IV enzyme , found on the chromosomal locus of Chromosome 2 at the 2q24.2 position, which acts as the CD26 antigen , belonging to the CD molecules gene family , and the DASH gene family . (wellnessadvocate.com)
  • On and in our body's cells, CD40 Antigen is a surface glycoprotein expressed on all mature B lymphocytes, and a member of the tumor necrosis factor receptor superfamily with specificity for CD40 ligand , that plays an important role in B-cell development, growth, and differentiation. (wellnessadvocate.com)
  • P-glycoprotein (P-gp) expressed on human antigen presenting cells (APC) regulates alloantigen-dependent T-cell activation, but the associated mechanisms are not well understood. (meta.org)
  • To expand the full repertoire of γδT without bias toward specific TCRs, we made use of artificial antigen-presenting cells loaded with an anti γδTCR antibody that promoted unbiased expansion of the γδT repertoire. (aacrjournals.org)
  • Both freshly isolated and expanded cells showed heterogeneity of differentiation markers, with a less differentiated phenotype in the Vδ1 and Vδ1 neg Vδ2 neg populations. (aacrjournals.org)
  • Here, we show that artificial antigen-presenting cells that can be used within good manufacturing practice (GMP) protocols can result in the unbiased expansion of a wide range of repertoires. (aacrjournals.org)
  • Instead, TACI-deficient QM B cells remained in the cell cycle longer than TACI-proficient QM cells and had impaired plasma cell differentiation in response to NP-Ficoll. (elsevier.com)
  • Vong, AM. Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection. (umassmed.edu)
  • Dendritic cells (DC) represent professional antigen-presenting cells that develop from hematopoietic progenitors through successive steps of differentiation. (naver.com)
  • Stem cell genes and genes related to the multilineage differentiation potential and proliferative state of progenitor cells were downregulated. (naver.com)
  • Differential expression of the transcription factor NF-κB during human mononuclear phagocyte differentiation to macrophages and dendritic cells. (naver.com)
  • Origin and differentiation of dendritic cells. (naver.com)
  • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated. (naver.com)
  • IgG-switched memory B cells in IL-6 knock-in mice displayed a diverse antibody repertoire and high specificity against immunized antigen. (bloodjournal.org)
  • 2 ⇓ - 4 However, the generation of class-switched, antigen-specific antibody responses by human B cells is still a major challenge. (bloodjournal.org)
  • When added to B-cell primary cultures, heme enhanced the transcription of Blimp-1, the master regulator of plasma cells, and skewed plasma cell differentiation toward the IgM isotype, decreasing the IgG levels in vitro. (bloodjournal.org)
  • Resting mature-B cells resume proliferation and then differentiate into antibody-secreting plasma cells in response to antigen stimulation or polyclonal stimulation. (bloodjournal.org)
  • An alternative pathway is to undergo class switch recombination (CSR) and somatic hypermutation (SHM) to become plasma cells, secreting isotypes of Igs such as IgG or IgA with greater affinity for a specific antigen. (bloodjournal.org)
  • When exposed to in vitro hepatogenic differentiation, ADHLSCs are capable to differentiate, either in vitro or in vivo, into hepatocyte-like cells [ 4 ]. (hindawi.com)
  • Antigen-induced differentiation of murine myeloma cells. (jax.org)
  • Rohrer, J W. and Lynch, R G., "Antigen-induced differentiation of murine myeloma cells. (jax.org)
  • LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. (colorado.edu)
  • The differentiation of monocytes into dendritic cells (DC) is a key mechanism by which the innate immune system instructs the adaptive T cell response. (colorado.edu)
  • In the periphery, the antigen is found on a few percent of lymph node and not on splenic T cells, and it is absent in nude mice. (elsevier.com)
  • Liu S, Wan J, Kong Y, Zhang Y, Wan L, Zhang Z. Inhibition of CRL-NEDD8 pathway as a new approach to enhance ATRA-induced differentiation of acute promyelocytic leukemia cells. (medsci.org)
  • Furthermore, MLN4924 effectively enhanced ATRA-induced differentiation of APL cells by promoting autophagy. (medsci.org)
  • Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells. (ox.ac.uk)
  • Nine mAbs (CD35, CD37, CD49c, CD50, CD54, CD66, CD81, CD88, CD102) stained bovine cells but the cellular distribution of the bovine antigen was different to that reported in humans implying either a different cellular distribution for these antigens in cattle or a reaction with a different molecule. (ox.ac.uk)
  • A series of monoclonal antibodies recognizing myeloid differentiation antigens were prepared by immunizing Balb/c mice with HL-60 cells. (ashpublications.org)
  • We have termed these antigens Pro- Im1 and Pro-Im2, respectively (Pro for using HL-60 promyelocytes as an immunogen and Im for the presence of these antigens on immature cells). (ashpublications.org)
  • Both antibodies mediated complement-dependent inhibition of CFU-GM, BFU-E, and CFU-GEMM formation assayed by soft agar colony and burst formation, indicating the expression of these antigens by early hematopoietic precursor cells. (ashpublications.org)
  • This was further confirmed by the induction of HL-60 cells by TPA to differentiate into more mature monocytes and macrophages, accompanied by the loss of both antigens. (ashpublications.org)
  • Both antigens were absent from thymocytes and peripheral T cells. (ashpublications.org)
  • Analysis of 150 cases of various myeloid and lymphoid malignancies demonstrated Pro-Im1 and Pro-Im2 expression on myeloblasts and promyelocytes from some acute myelogenous leukemias as well as some B cell malignancies, suggesting that these antigens are shared by early hematopoietic cells and a subset of B cells. (ashpublications.org)
  • During maturation of normal hematopoietic progenitors, there appears to be differentiation-dependent expression of adhesion receptors, which may contribute to the homing and lodging of stem progenitor cells into the marrow and for the eventual release of mature effector cells from the marrow cavity. (elsevier.com)
  • Using a model of long-term marrow culture, we studied the expression pattern of different lineage cell antigens and cell adhesion molecules on the nonadherent cells in canine long-term marrow culture. (elsevier.com)
  • Small CD4 + cells, the majority of which are negative for other T-cell antigens during the first 2 weeks of culture, express low levels of CD4 (CD4(lo)) and coexpress granulocytic and/or monocytic markers, These CD4(lo) cells have progenitor potential as measured by the long-term culture-initiating cell assay and differentiate into myeloid (first wave) and lymphoid (second wave) cells. (elsevier.com)
  • Antigen levels detected by monocyte- granulocyte-specific monoclonal antibodies AML-2-23, 61D3, and 63D3 increased dramatically after differentiation of HL-60 cells along the granulocytic pathway by the addition of dimethyl formamide (DMF), dimethylsulfoxide (DMSO), or cis-retinoic acid. (ashpublications.org)
  • In contrast, treatment of HL-60 cells with phorbol 12-myristate 13-acetate (PMA), which also induced differentiation along the monocyte pathway, had no effect on the expression of these monocyte-associated antigens. (ashpublications.org)
  • The expression of antigens on HL-60 cells recognized by the granulocyte-specified monoclonal antibodies PMN 6 and PMN 29 decreased after treatment of HL- 60 cells with PMA, but remained constant after treatment with DMF, DMSO, cis-retinoic acid, PHA-LCM, or MLC. (ashpublications.org)
  • Antigen exposure via airway epithelia is often associated with a failure to prime or with the preferential priming of Th2 cells. (jci.org)
  • To establish a potential mechanism for such preferential priming, we examined the initial interactions between antigens and resident antigen-presenting cells (APCs) within the lung. (jci.org)
  • We show that intranasally delivered antigens are preferentially taken up and can be presented to antigen-specific T cells by a resident population of CD11c bright APCs. (jci.org)
  • Cross-reactivity of human leucocyte differentiation antigen monoclonal antibodies on porcine cells. (ox.ac.uk)
  • These are antigens encoded by genes expressed by both tumor cells as well as their normal cell counterparts. (biomedcentral.com)
  • Secondly, we will summarize the data on immune responses generated to various proteins found on melanoma cells with an example of how differentiation antigens can be used as immunologic targets. (biomedcentral.com)
  • The molecular characterization of several tumor antigens identified by both by T cells [ 4 ] and serology [ 5 ], has provided several candidates for the development of immunotherapy of various malignancies. (biomedcentral.com)
  • Prominent examples of this type of vaccine based on undefined antigen are intact cells, cell lysate, total (amplified) RNA vaccines and heat-shock proteins. (biomedcentral.com)
  • Expression of common acute lymphoblastic leukaemia antigen and terminal deoxynucleotidyl transferase in normal mononuclear blood cells during diffusion chamber culture. (biomedsearch.com)
  • A high percentage of cALL antigen positive cells and later on TdT containing cells appeared during culture. (biomedsearch.com)
  • The interpretation of the ring-like stained cells is still preliminary, but it cannot be excluded, that these cells represent a cell population with more than lymphatic differentiation capacity. (biomedsearch.com)
  • see the Perspective by Dustin and Meyer-Hermann) used multiphoton microscopy and imaging flow cytometry to visualize the localization of antigen in B lymphocytes during an immune response. (sciencemag.org)
  • A set of monoclonal antibodies specifically reactive with porcine leukocyte differentiation antigens were used with flow cytometry to determine the proportions of leukocyte subpopulations. (aasv.org)
  • Self antigens, in the form of differentiation antigens, and altered self antigens, in the form of mutations, are recognized on melanoma and other cancers by the immune system. (grantome.com)
  • Preclinical animal studies have convincingly demonstrated that tumor immunity to self antigens can be actively induced and can translate into an effective anti-tumor response. (biomedcentral.com)
  • Traditionally, vaccines have been effective in the induction of protective immunity to bacteria and viruses based on recognition of foreign, or non-self, antigens on these pathogens. (biomedcentral.com)
  • While some mutated gene products (altered self) have been identified, surprisingly, the vast majority of antigens on cancers characterized to date are unaltered self antigens. (biomedcentral.com)
  • (1) identified the first melanoma antigen gene, MAGE-1 3 ( MAGE-A1 ), in a human melanoma cell line. (aacrjournals.org)
  • A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. (rupress.org)
  • A first antigen recognized by such CTL clones was previously shown to be encoded by the tyrosinase gene. (rupress.org)
  • We report here the identification of another gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that are restricted by HLA-A2. (rupress.org)
  • False negative results seen with immunochromatographic MPT 64 antigen assay could be due to mutations within the mpt64 gene. (innovareacademics.in)
  • In our body, CD30 Ligand (CD153 Antigen) is a glycoprotein membrane-bound tumor necrosis family member, found primarily on activated T-lymphocytes that binds specifically to CD30 antigen, that may play a role in inflammation and immune regulation, encoded by the TNFSF8 gene . (wellnessadvocate.com)
  • Here we describe a new mouse strain, in which human interleukin 6 (IL-6) gene encoding the cytokine that is important for B- and T-cell differentiation was knocked into its respective mouse locus. (bloodjournal.org)
  • Recent studies show that retinoic acid-induced gene G (Rig-g), first identified from an APL cell line NB4 treated with ATRA, is able to negatively regulate SCF-E3 ligase activities and largely decrease protein levels of cullin1 and β-TrCP, indicating a significant role for inhibition of CRL-NEDD8 pathway in the ATRA-induced APL differentiation[ 10 , 11 ]. (medsci.org)
  • In addition, the protozoan genomes were examined by PCR for homologs of surface antigen genes of T. gondii, and by Southern hybridization to the heterologous rRNA gene probe pSM 389. (unifesp.br)
  • Strains OH3, S11, ts-4, and RH shared identical riboprints, and OH3, S11, and ts-4 have p22 and p30 surface antigen gene structures similar to RH. (unifesp.br)
  • Together, the variation in riboprints and surface antigen gene structure reflects the phylogenetic diversity among these coccidia, and in addition, confirms the value of riboprinting in the identification of apicomplexan parasites such as T gondii. (unifesp.br)
  • CD19 is a signal-transduction molecule and CD20 is part of a multimeric receptor complex regulating cell cycle progression and B-cell differentiation. (aacrjournals.org)
  • In this study we set out to determine whether cytotoxic CD8 + T-cell responses specific for peptides derived from CD19 and CD20 antigens occur in healthy individuals and patients with B-cell malignancies. (aacrjournals.org)
  • Low CD20 antigen expression levels have been detected on normal T-lymphocytes. (novusbio.com)
  • CD20 is expressed during early pre-B cell development and remains until plasma cell differentiation. (justia.com)
  • Thus, the CD20 surface antigen has the potential of serving as a candidate for "targeting" of B cell lymphomas. (justia.com)
  • Membrane molecules as differentiation antigens of murine macrophages. (nih.gov)
  • The addition of antibody SB-10 Fab fragments to human MSCs undergoing osteogenic differentiation in vitro accelerated the process, thereby implicating a role for ALCAM during bone morphogenesis and adding ALCAM to the group of cell adhesion molecules involved in osteogenesis. (ovid.com)
  • These molecules, known as "ligands to differentiation antigens ," are expected to be useful to both basic research and in the manufacture of safe cell-based therapies. (thefreedictionary.com)
  • Later, the CD designations were used to describe the recognized molecules, but had to be clarified by attaching the term antigen or molecule to the designation (e.g. (wikipedia.org)
  • In the example of CD4 & CD8, these molecules are critical in antigen recognition. (wikipedia.org)
  • Human Cell Differentiation Molecules Council (successor to the HLDA Workshops). (wikipedia.org)
  • Our analysis revealed specific changes in the expression of a large number of cell surface antigens including molecules involved in antigen uptake and processing, cell migration and antigen presentation. (naver.com)
  • Genes encoding such molecules were upregulated during DC differentiation as were genes encoding cytokines, cytokine receptors, chemokines and chemokine receptors. (naver.com)
  • Among thymocytes, the distribution of the B14 determinant largely overlaps with that of the TL antigen and of molecules binding peanut agglutinin. (elsevier.com)
  • Leucocyte Typing III: White Cell Differentiation Antigens: 654-55. (wikipedia.org)
  • White Cell Differentiation Antigens" McMichael, A. J., Oxford University Press. (freepatentsonline.com)
  • CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. (sciencemag.org)
  • Activation of LILRA2 on peripheral blood monocytes impaired GM-CSF induced differentiation into immature DC, as evidenced by reduced expression of DC markers (MHC class II, CD1b, CD40, and CD206), but not macrophage markers (CD209 and CD14). (colorado.edu)
  • Here we demonstrate that P-gp functions in IL-12-dependent monocyte differentiation into dendritic cell (DC) lineages during APC maturation, thereby regulating the capacity of myeloid-derived APCs to elicit alloimmune Th1 responses. (meta.org)
  • Therefore, LILRA2 activation, by altering GM-CSF-induced monocyte differentiation into immature DC, provides a mechanism for down-regulating the ability of the innate immune system to activate the adaptive T cell response while promoting an inflammatory response. (colorado.edu)
  • The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
  • Communication received through cell contact is critical for the differentiation of specialized effector cell populations during the immune response. (sciencemag.org)
  • Our findings underscore the importance of antigen-dependent, direct cytotoxic immune responses in stroke and suggest modulation of CTLs and their effector pathways as a potential new strategy for stroke therapy. (sigmaaldrich.com)
  • Recognition of these antigens presents problems, especially how one can overcome immune tolerance. (grantome.com)
  • These findings (i) demonstrate the value of using a panel of antibodies for leukocyte antigens to differentiate plasmacytomas from other cutaneous and oral round cell tumours, and (ii) suggest that immune recognition and responsiveness within tumours may play a role in the behaviour of plasmacytomas in dogs by affecting tumour cell growth and differentiation. (elsevier.com)
  • Thus, these studies prove that Tfh immune response can be regulated positively or negatively, and to better understand Tfh response modulation, it is important to characterize Tfh differentiation and its regulators. (frontiersin.org)
  • However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody responses. (bloodjournal.org)
  • In this study, the impact of hepatogenic differentiation and inflammation priming on the ADHLSCs' immune profile was assessed in vitro and compared to that of mature hepatocytes. (hindawi.com)
  • Accordingly, the current work was designed to learn more about the ADHLSC immune profile modulation after in vitro hepatogenic differentiation and in an inflamed environment. (hindawi.com)
  • The innate immune microenvironment within different organs and tissues has the potential to impact significantly on T cell priming and differentiation. (jci.org)
  • Diagnosis of plasmacytoma was confirmed in paraffin-embedded tissues with a panel of leukocyte differentiation antigen markers that included cross-reactive antibodies for Mb-1 (CD79a), CD3, and vimentin and canine-specific antibodies for CD45RA and CD18. (elsevier.com)
  • The markers were derived during a series of Human Leukocyte Differentiation Antigen workshops. (thefreedictionary.com)
  • The hiPS-MSCs expressed mesenchymal markers (CD90, CD73 and CD105), possessed multipotency characterized by tri-lineages differentiation: osteogenic, adipogenic and chondrogenic and lost pluripotency - as seen with the loss of markers OCT3/4 and TRA-1-81 - and tumorigenicity. (nature.com)
  • To evaluate prognostic markers, prostate-specific antigen (PSA), prostate health index (PHI) and prostate volume indexed measures (PSAD and PHID) for predicting positive prostate cancer biopsies in magnetic resonance (MR) transrectal ultrasound fused versus non-fused transrectal ultrasonography biopsy. (urotoday.com)
  • These functions follow opposite rules to the classic CD8 effector functions since they are generated prior to cell expansion and decline before antigen elimination. (frontiersin.org)
  • Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity. (plos.org)
  • ThCTL require Blimp-1 for their differentiation, suggesting a unique effector CD4 population. (umassmed.edu)
  • Studies of their tumor antigens (Tags) have led to appreciation of the role of tyrosine phosphorylation, PI3K and p53 in oncogenic transformation. (tufts.edu)
  • Immunization against defined tumor antigens using a xenogeneic DNA vaccine is currently being tested in early phase clinical trials for the treatment of melanoma and prostate cancers, with proposed trials for breast cancer and Non-Hodgkin's Lymphoma. (biomedcentral.com)
  • Tumor antigens can be broadly categorized into two types - those that are undefined and others that are well defined. (biomedcentral.com)
  • Serologic responses to specific parasite antigens can differentiate acutely infected patients from those chronically infected. (ajtmh.org)
  • We conclude that TACI has dual B cell-autonomous functions, inhibiting prolonged B cell proliferation and stimulating plasma cell differentiation, thus resolving the longstanding paradox that TACI may have both B cell-inhibitory and -stimulatory functions. (elsevier.com)
  • By promoting plasma cell differentiation earlier during clonal expansion, TACI may decrease the chances of autoantibody production by somatic hypermutation of Ig genes in response to T-independent Ags. (elsevier.com)
  • Our results reveal a new function for heme as a ligand of Bach2 and as a modulatory signal involved in plasma cell differentiation. (bloodjournal.org)
  • Hence, in this review, we have highlighted and interlinked molecular signaling from cytokines, surface receptors, transcription factors, ubiquitin ligase, and microRNA as positive and negative regulators for Tfh differentiation. (frontiersin.org)
  • Malignant fibrous histiocytoma: expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies. (thefreedictionary.com)
  • Characterization and differentiation of a soluble lipopolysaccharide type antigen from Treponema hyodysenteriae. (arizona.edu)
  • Here we report on the immunopurification of the SB-10 antigen and its identification as activated leukocyte-cell adhesion molecule (ALCAM). (ovid.com)
  • Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD antigens molecule have been identified. (sinobiological.com)
  • Background: TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. (gob.ar)
  • In addition, and irrespective of the TSSA variant, over-expression of this molecule leads to an enhanced trypomastigote-to-amastigote conversion, indicating a possible role of TSSA also in parasite differentiation. (gob.ar)
  • Your search returned 17 mal, T cell differentiation protein Biomolecules across 5 suppliers. (biocompare.com)
  • Jessell TM and Dodd J (1984) Structure and expression of differentiation antigens on functional subsets of primary sensory neurons. (springer.com)
  • Kapadia A, Feizi T and Evans MJ (1981) Cahnges in the expression and polarization of blood group I and i antigens in post-implantation embryos and teratocarcinomas of mouse associated with cell differentiation. (springer.com)
  • Mollicone R, Davies R, Evans B, Dalix AM and Oriol R (1985) Cellular expression and genetic control of ABH antigens in primary sensory neurons of marmoset baboon and man. (springer.com)
  • Significance of myeloid antigen expression in precursor T lymphoblastic lymphoma. (nih.gov)
  • PyST inhibited Akt and its effect on differentiation was reversed by the expression of activated Akt. (tufts.edu)
  • Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
  • Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. (uni-regensburg.de)
  • Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma. (thefreedictionary.com)
  • Interestingly, miR-17-92 and FOXO1 act as a positive as well as a negative regulator of Tfh differentiation depending on the time of expression and disease specificity. (frontiersin.org)
  • In contrast, P-gp blockade during differentiation inhibited CD1a induction, down-regulated CD80 expression, enhanced CD86 expression and induced CD68 expression. (meta.org)
  • In contrast, expression of STAT factors increased during DC differentiation and their expression was virtually unaffected by TNFα. (naver.com)
  • HD39 (B3), A B Lineage-Restricted Antigen Whose Cell Surface Expression is Limited to Resting and Activated Human B Lymphocytes," J. Immunol. (freepatentsonline.com)
  • mAbs from each of the 27 different CD groups that contained a mAb reacting with cattle were further investigated to compare the cellular expression of the antigen in cattle with that reported for the different CD antigens in humans. (ox.ac.uk)
  • alpha Pro-Im1 and alpha Pro-Im2 were used to investigate the surface expression and tissue distribution of these two antigens. (ashpublications.org)
  • Furthermore, these pulmonary APCs demonstrated a marked expression of IL-6 and IL-10 within hours of antigen uptake, suggesting that resident tissue APCs have the capacity to promote Th2 T cell differentiation in situ. (jci.org)
  • The act of the APC ingesting antigen and breaking it down stimulates the expression of B7. (brainscape.com)
  • The investigation has allowed the identification of several bovine homologues of human CD antigens that have not been previously defined in cattle and the cross-reacting mAbs will be valuable reagents for future investigations of bovine immunology. (ox.ac.uk)
  • The present study investigated (i) the relationship between standardised morphometric AgNOR parameters (argyrophilic nucleolar organiser region-associated proteins) and MIB1 growth fraction, and (ii) their correlation with immunohistochemical p53, sex steroid receptor status and histopathological differentiation grade in serial paraffin sections from 39 breast carcinomas. (hindawi.com)
  • it may therefore represent a new receptor important for myeloid differentiation. (sciencemag.org)
  • These compounds act as high-affinity ligands for a member of the nuclear hormone receptor superfamily PPARγ, which has been shown to play an important role in adipocyte differentiation. (aspetjournals.org)
  • In this study, we investigated whether leukocyte Ig-like receptor A2 (LILRA2) regulates DC differentiation by using leprosy as a model. (colorado.edu)
  • Thirty-seven subpanels of monoclonal antibodies (mAbs) included within the Vth International Workshop on Human Leucocyte Differentiation Antigens (Vth Workshop) were assayed for reactivity with bovine peripheral blood leucocytes. (ox.ac.uk)
  • Thirty-six subpanels of monoclonal antibodies (mAbs) supplied to the Fifth International Workshop on Human Leucocyte Differentiation Antigens were assayed on porcine peripheral blood leucocytes for cross-reactivity. (ox.ac.uk)
  • The cullin-RING ligase (CRL)-NEDD8 pathway maintains essential cellular processes, including cell cycle progression, apoptosis, autophagy, DNA repair, antigen processing and signal transduction. (medsci.org)
  • Although T cell lymphomas occur infrequently, they express early T cell differentiation antigens and are less often aneuploid than are B cell tumors. (thefreedictionary.com)
  • Each B call within the host expresses a different antibody on its surface-thus, one B cell will express antibody specific for one antigen, while another B cell will express antibody specific for a different antigen. (justia.com)
  • A cell surface antigen that is expressed only during a specific period of embryological differentiation. (thefreedictionary.com)
  • The HB-6, CDw75, and CD76 Differentiation Antigens are Unique Cell-Surface Carbohydrate Determinants Generated by the .beta. (freepatentsonline.com)
  • These results suggest that normal myeloid differentiation may be dependent on various signals and that morphological and cell surface marker maturity may, under some conditions, be separable. (ashpublications.org)
  • Role of the CD22 Human B Cell Antigen in B Cell Triggering by Anti-Immunoglobulin," J. Immunol. (freepatentsonline.com)
  • CD antigens can act in lot of ways, like as recepters or ligands in terms of physiology. (sinobiological.com)
  • We have used a mouse melanoma model to show that mice can be tolerant to the tyrosinase family of differentiation antigens. (grantome.com)
  • In aim 4, we will continue to create more relevant mouse models of melanoma that develop endogenous invasive melanomas to study tumor immunity against differentiation and mutant antigens. (grantome.com)
  • B14‐2‐14 offers an additional method for identification and selection of thymocytes at different stages of differentiation, and should also be useful for studies of the Thy‐1 antigen. (elsevier.com)
  • Akt inhibitor could block SV40ST activation of myoblast differentiation in a dose dependent manner. (tufts.edu)
  • Such antibody production most typically ceases (or substantially decreases) when the foreign antigen has been neutralized. (justia.com)
  • The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens of interest. (biocompare.com)
  • Gamma delta T (γδT) lymphocytes have both cytotoxic and professional antigen-presenting capacity ( 1-4 ), but have been relatively overlooked in terms of their potential role as mediators of antibody-dependent cell-mediated cytotoxicity (ADCC), particularly in the context of mAb treatments of cancer. (aacrjournals.org)
  • Although antigen-specific human IgM antibody responses are generated, the achievement of affinity maturation and class-switching from the IgM to the IgG isotype has been particularly difficult. (bloodjournal.org)
  • Undefined and unidentified antigens are found in both allogeneic and autologous vaccine settings described below. (biomedcentral.com)
  • Confirmation and differentiation of antibodies to human immunodeficiency virus 1 and 2 with a strip-based assay including recombinant antigens and synthetic peptides. (aaccjnls.org)