Antigens dermatophagoides. Medical search

Species of American house dust mite, in the family PYROGLYPHIDAE.

Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.

Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.

Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.

Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.

Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.

An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Substances that are recognized by the immune system and induce an immune reaction.

Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.

Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.

Infestations with arthropods of the subclass ACARI, superorder Acariformes.

Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.

Substances elaborated by bacteria that have antigenic activity.

Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.

A species of mite that causes SCABIES in humans and sarcoptic mange in other animals. Specific variants of S. scabiei exist for humans and animals, but many have the ability to cross species and cause disease.

Substances elaborated by viruses that have antigenic activity.

A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.

A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

Skin tests in which the sensitizer is injected.

ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.

Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.

Administration of a soluble dosage form by placement under the tongue.

A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.

Substances found in PLANTS that have antigenic activity.

A family of insects in the order Dictyoptera (COCKROACHES), including genera Blattella, Parcoblatta, and Symploce.

The surface of a structure upon which one stands or walks.

Conjunctivitis due to hypersensitivity to various allergens.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.

Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

Sites on an antigen that interact with specific antibodies.

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Substances of fungal origin that have antigenic activity.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.

Articles of cloth, usually cotton or rayon and other synthetic or cotton-blend fabrics, used in households, hospitals, physicians' examining rooms, nursing homes, etc., for sheets, pillow cases, toweling, gowns, drapes, and the like.

The major group of transplantation antigens in the mouse.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.

Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.

Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.

The fertilizing element of plants that contains the male GAMETOPHYTES.

A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.

Antibodies produced by a single clone of cells.

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

The contamination of indoor air.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

Proteins prepared by recombinant DNA technology.

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.

Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.

Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence. (1/409)

BACKGROUND: Relatively little is known about risk factors for the persistence of asthma and respiratory symptoms from childhood into adolescence, and few studies have included objective measurements to assess outcomes and exposure. METHODS: From a large cross sectional study of all 4th grade school children in Munich (mean age 10.2 years), 234 children (5%) with active asthma were identified. Of these, 155 (66%) were reinvestigated with lung function measurements and bronchial provocation three years later (mean age 13.5 years). RESULTS: At follow up 35.5% still had active asthma. Risk factors for persisting asthma symptoms in adolescence were more severe asthma (OR 4.94; CI 1.65 to 14.76; p = 0.004) or allergic triggers (OR 3.54; CI 1.41 to 8.92; p = 0.007) in childhood. Dampness was associated with increased night time wheeze and shortness of breath but not with persisting asthma. Risk factors for bronchial hyperreactivity in adolescence were bronchial hyperreactivity in childhood (p = 0.004), symptoms triggered by allergen exposure (OR 5.47; CI 1.91 to 25.20; p = 0.029), and damp housing conditions (OR 16.14; CI 3.53 to 73.73; p < 0.001). In a subgroup in whom house dust mite antigen levels in the bed were measured (70% of the sample), higher mite antigen levels were associated with bronchial hyperreactivity (OR per quartile of mite antigen 2.30; CI 1.03 to 5.12; p = 0.042). Mite antigen levels were also significantly correlated with dampness (p = 0.05). However, the effect of dampness on bronchial hyperreactivity remained significant when adjusting for mite allergen levels (OR 5.77; CI 1.17 to 28.44; p = 0.031). CONCLUSION: Dampness at home is a significant risk factor for the persistence of bronchial hyperreactivity and respiratory symptoms in children with asthma. This risk is only partly explained by exposure to house dust mite antigen. (+info)

Production of recombinant Der fI (a major mite allergen) by Aspergillus oryzae. (2/409)

Der fI is a major mite allergen. To produce Der fI by Aspergillus oryzae, we placed a DNA fragment encoding precursor-type recombinant Der fI E(-1)K (reDer fI E(-1) K), which had the C-terminal amino acid of the pro-sequence (Glu) changed to Lys, downstream of the glaA gene promoter and introduced it into Aspergillus oryzae. In liquid culture, most of the reDer fI E(-1)K produced by the transformants was degraded when culture was shaken vigorously. However, the degradation of reDer fI E(-1)K was suppressed when it was shaken gently. The processed reDer fI E(-1)K could be obtained after lysylendopeptidase and endoglycosidase Hf (Endo Hf) treatment. The yield of processed reDer fI E(-1)K was 8 mg/l. When the transformant was grown on a wheat bran culture, the yield of processed reDer fI E(-1)K reached 48 mg/kg. Because processed reDer fI E(-1)Ks obtained from both cultures had almost the same IgE-binding activity and elicited the same skin reaction as native Der fI, they could be very useful for diagnostic purposes or immunotherapy. (+info)

Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae. (3/409)

House dust mite allergen is thought to be a major cause of asthma. Characterization of these allergen molecules is therefore an important step for the development of effective diagnostic and therapeutic agents against mite-associated allergic disorders. Here we report molecular cloning and expression of the group 6 (chymotrypsin-like) allergen from the house dust mite, Dermatophagoides farinae. Sequencing analysis indicates that cloned cDNA, designated Der f 6, encodes a 279 amino acid polypeptide which conserves a primary structure characteristic for chymotrypsin-like serine proteases found in mammals. Recombinant Der f 6 expressed in Escherichia coli bound IgE in a pool made of 20 sera, and induced histamine release from patients' peripheral blood cells. (+info)

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (4/409)

House dust mite (HDM) allergens are important factors in the increasing prevalence of asthma. The lung epithelium forms a barrier that allergens must cross before they can cause sensitization. However, the mechanisms involved are unknown. Here we show that the cysteine proteinase allergen Der p 1 from fecal pellets of the HDM Dermatophagoides pteronyssinus causes disruption of intercellular tight junctions (TJs), which are the principal components of the epithelial paracellular permeability barrier. In confluent airway epithelial cells, Der p 1 led to cleavage of the TJ adhesion protein occludin. Cleavage was attenuated by antipain, but not by inhibitors of serine, aspartic, or matrix metalloproteinases. Putative Der p 1 cleavage sites were found in peptides from an extracellular domain of occludin and in the TJ adhesion protein claudin-1. TJ breakdown nonspecifically increased epithelial permeability, allowing Der p 1 to cross the epithelial barrier. Thus, transepithelial movement of Der p 1 to dendritic antigen-presenting cells via the paracellular pathway may be promoted by the allergen's own proteolytic activity. These results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens. (+info)

Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. (5/409)

A positive lymphocyte transformation test to beta-lactams (beta-L) was found in 12 of 29 subjects with adverse drug reaction (ADR) to beta-L, irrespective of either the type of clinical manifestation or the presence of specific serum IgE. Short-term T cell lines specific for penicillin G, amoxicillin, and ampicillin could be generated only from subjects with ADR (eight with positive and one with negative lymphocyte transformation test), while streptokinase and Dermatophagoides pteronyssinus group 1 (Der p 1)-specific T cells were obtained from all these subjects, from 7 atopic Der p-sensitive donors without history of ADR and 17 healthy nonatopic donors. Streptokinase-specific T cells from all subjects showed intracellular expression of IFN-gamma with poor or no IL-4, whereas Der p 1-specific T cells exhibited IFN-gamma but low or no IL-4 expression in nonatopics, and remarkable IL-4 expression in atopic donors. By contrast, all penicillin G-, ampicillin-, and amoxicillin-specific short-term T cell lines showed high intracellular expression of IL-4, IL-5, and IL-13, but poor or no expression of IFN-gamma, thus exhibiting a clear-cut Th2 profile. Accordingly, most penicillin G-specific T cell clones derived from two subjects with ADR released high concentrations of IL-4 alone or IL-4 and IFN-gamma. These data suggest that cytokines produced by Th2 cells play an important role in all beta-L-induced ADR, even when late clinical manifestations occur and an IgE-mediated mechanism is apparently indemonstrable. (+info)

Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. (6/409)

Sensitization towards a panel of eight regional inhalant allergens was evaluated among 107 patients with allergic rhinitis and/or asthma. A total of 32 children (age 5-13 years, mean 9 years; 18 male, 14 female), 75 adolescents and adults (aged 14-66 years, mean 32 years; 21 male, 54 female) and 20 normal control volunteers (aged 16-46, mean 30 years; 4 male, 16 female) were evaluated via skin prick test. A weal response of 3 x 3 mm or greater was taken to be positive. The sensitization rates among individuals to these allergens were: house dust mites, Dermatophagoides pteronyssinus (77.57%), Blomia tropicalis (71.96%), Austroglycyphagus malaysiensis (33.64%), pollen, palm oil Elaeis guineensis (22.43%), Acacia auriculiformis (12.15%), fern spore, resam Dicranopteris spp (11.21%), fungal spores: Curvularia fallax (8.41%) and Exserohilum rostratum (13.08%). There were significantly higher frequencies of sensitization to these allergens among allergic individuals compared to normal controls, and among atopic individuals with two allergy manifestations (rhinitis and asthma) compared to those with only one. No difference was noted between children and adults in the allergic group. In conclusion, the allergic patients were highly sensitized to dust mites and sensitization to regional pollen and spores was also documented. They should be considered as relevant and be included in skin test batteries in Indonesia. (+info)

Role of allergy in nasal polyps of Thai patients. (7/409)

As distinct from many countries, allergy in Thailand is of the perennial type which may play a role in the formation of nasal polyps. Forty consecutive patients with nasal polyps and 30 normal subjects as control were studied at the Allergy Clinic, Department of Otolaryngology, Pramongkutklao Hospital. A positive clinical history and skin allergy testing are diagnostic criteria for allergy. In the nasal polyps group, these were 28 males and 12 females, aged between 12-65 years, with an average age of 38.5 years. In the control group, there were 18 males and 12 females, aged between 15-53 yeas, with an average age of 34 years. All had received prick skin testing with 6 common aeroallergens. The prick skin test was considered positive when the wheal was > or = 3 mm with surrounding erythema. Twenty-four of 40 patients (60%) with nasal polyps had a positive prick skin test, while 6 in the 30 control cases (20%) had a positive prick skin test. This difference was statistically significant (P = 0.0019), Odd's ratio = 6.0 which means allergic persons were 6 times more prone to have polyps form than normal persons. (+info)

Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p I allergen-induced animal model of airway inflammation. (8/409)

Interleukin-12 (IL-12) is a key cytokine, which promotes T helper type 1 (Th1) cell-mediated immunity and inhibits Th2-type responses. It has been previously shown that IL-12 administration during active immunization following a single allergen exposure can prevent antigen-induced increases in immunoglobulin E (IgE) formation, Th2 cytokine production and bronchoalveolar lavage (BAL) eosinophils in a murine model of allergic airway inflammation. Thus, these studies have now been extended and two IL-12 treatment protocols on this murine model were evaluated. Administration of IL-12 during the active immunization strikingly increased Der p I-specific serum IgG2a and transiently decreased the levels of IgG1 and IgE antibodies following multiple allergen challenges. Such early treatment of IL-12 down-regulated IL-5 production and modestly up-regulated interferon-gamma production but did not effect BAL eosinophilia. These results suggest that repeated exposure to antigen and IL-12 is necessary to maintain a persistent Th1-recall response. Furthermore, administration of IL-12 to actively immunized mice, in which Th2-associated responses were established, had a significant effect on IgG2a synthesis and a modest effect on IgE levels, also down-regulation of IL-5 production, and markedly increased interferon-gamma production and abolished recruitment of eosinophils. Therefore, these data indicate that IL-12 can inhibit antigen-induced eosinophil infiltration into airways, despite the existence of a Th2-associated response. Taken together, these studies suggest that IL-12 may be useful as an immunotherapeutic agent in the treatment of such pulmonary allergic disorders as bronchial asthma. (+info)

"Dermatophagoides farinae antigen f 1". US National Library of Medicine Medical Subject Headings. Retrieved 3 April 2015. Takai ... "Dermatophagoides pteronyssinus antigen p 1". US National Library of Medicine Medical Subject Headings. Retrieved 3 April 2015. ... "Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1". Journal of Immunology ... Der f 1 is found in the fecal pellets of the American house dust mite Dermatophagoides farinae. Der f 1 is considered a major ...

https://en.wikipedia.org/wiki/Peptidase_1_(mite)

DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens. The ... association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the ... Tissue Antigens. 40 (2): 90-7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780. Chou HT, Chen CH, Chen JY, Chang KC (2007 ... "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565-74. doi: ...

https://en.wikipedia.org/wiki/HLA-DR11

SP-D increases bacterial antigen presentation by dendritic cells whereas SP-A blocs differentation of the immature dendritic ... Dermatophagoides pteronyssinus) allergens". Clinical and Experimental Immunology. 106 (2): 367-373. doi:10.1046/j.1365- ... "Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells". American Journal of ...

https://en.wikipedia.org/wiki/Collectin

Antigens, Dermatophagoides * Asthma / physiopathology* * Bronchial Provocation Tests* * Double-Blind Method * Female * Forced ...

https://pubmed.ncbi.nlm.nih.gov/7997002/

Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, comment code. Target: Both males and females 1 YEARS - 150 YEARS. ... Aspergillus fumigatus: (ng antigen/mL)*(1mL/45mg dust)*(1ug antigen/1000 ng antigen)*(1000 mg dust/1 g dust) = ug Aspergillus ... Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS - 150 ... Dust mite Dermatophagoides pteronyssinus 1 (Der p 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS ...

https://wwwn.cdc.gov/Nchs/Nhanes/2005-2006/ALDUST_D.htm

Mite antigen was found in circulating immune complexes in three of eight KS patients (10). This and another study (11) have not ... Japanese investigators have proposed an association between house-dust mites (Dermatophagoides) and KS. In one study, serum ... Furusho K, Ohba T, Soeda T, Kimoto K, Okabe T, Hirota T. Possible role for mite antigen in Kawasaki disease. Lancet 1981;2:194- ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/00001256.htm

Antigen Versatility on DC Phenotype Availability of diverse DCs at various sites of antigen exposure or immune invasion depends ... Dermatophagoides pteronyssinus or European HDM), which has N-acetylglucosamine, galactose and sialic acid.[40] Apart from Der p ... Different types of antigens are recognized through pattern recognition receptors on DCs for immune precipitation to allergy or ... Antigens, which induce immune response, are called immunogens, and if they elicit allergies (type I hypersensitivity), they are ...

https://www.medscape.com/viewarticle/812906_3

... and Dermatophagoides-pteronyssinus antigens. Tracheal explants from male Hartley-guinea-pigs were incubated with 0 to 100 ... Fourteen swine farmers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. The ... The swine workers with positive skin reactions to swine confinement antigens had a higher prevalence of chronic cough, phlegm, ... microliters of a extract of a mixture of swine hair, pig food, and swine confinement building antigens. The potential of the ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=agricultur%2A+or+farm%2A&f1=%2A&Adv=0&terms=1&PageNo=603&RecNo=6030&View=f&

Within 12 to 24 hours after administration, the antigen-presenting cells migrate to the lymph nodes where they interact with ... Each tablet contains 12 SQ-HDM [6 SQ-HDM Dermatophagoides farinae and 6 SQ-HDM Dermatophagoides pteronyssinus], in a 1:1:1:1 ... For allergic rhinitis with or without conjunctivitis that is induced by Dermatophagoides farinae or Dermatophagoides ... At 60 minutes, allergen began to disappear from the submucosa, perhaps coinciding with uptake and processing by the antigen- ...

https://pdr.net/drug-summary/Odactra-dermatophagoides-farinae-and-dermatophagoides-pteronyssinus-24190

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. ... Neutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation. ... pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen. ...

https://profiles.wustl.edu/en/persons/gwendalyn-randolph/publications/?ordering=type&descending=true&page=3

Antigens, Dermatophagoides farinae. Antigens, Dermatophagoides pteronyssinus. Antigens, House Dust Mites. Dermatophagoides ... Dermatophagoides Antigens. Dermatophagoides farinae Allergens. Dermatophagoides farinae Antigens. Dermatophagoides ... Antigens, Dermatophagoides - Preferred Concept UI. M0419493. Scope note. Antigens from the house dust mites (DERMATOPHAGOIDES ... Antigens, Dermatophagoides pteronyssinus - Narrower Concept UI. M0116080. Preferred term. Antigens, Dermatophagoides ...

https://decs.bvsalud.org/en/ths/resource/?id=37544

Immunohistochemical study on proliferating cell nuclear antigen expression in ameloblastomas. Kim, J. & In Yook, J., 1994, In: ... of Dermatophagoides farinae in normal subjects and asthmatics.. Hong, C. S., Park, J. W. & Nahm, D. H., 1994 Dec, In: Yonsei ... Measurement of IgE and IgG subclass antibodies to whole body antigen and two major allergens (Der fI & Der fII) ... Immunohistochemical demonstration of the skin basement membrane antigens by the AMeX (acetone, methyl benzoate and xylene) ...

https://yonsei.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2016&publicationYear=2017&publicationYear=2019&author=57ce0b3a-05f6-4c00-8772-20f567c6e235&format=&ordering=publicationYearThenTitle&descending=false&nofollow=true&page=24

2 Antigens, Dermatophagoides. *2 Child. *2 Immunoglobulin E --blood. *. next > Date issued ...

https://imsear.searo.who.int/handle/123456789/30515/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=subject&filter_type_1=equals&filter_value_1=Adolescent&filter_field_2=author&filter_type_2=equals&filter_value_2=Pumhirun%2C+P&etal=0&filtername=subject&filterquery=Adult&filtertype=equals

Antigens, Dermatophagoides. Protease Inhibitors. Drug Delivery Systems. Drug Design. Immunity, Innate. Research team. Medicinal ...

https://repository.icr.ac.uk/handle/internal/3963

Antigens, Dermatophagoides -- administration & dosage. Antigens, Dermatophagoides -- immunology. Cytokines -- biosynthesis. ...

https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/53654/Details

Dermatophagoides Antigens 100% * Cockroaches 98% * Pyroglyphidae 91% * Atopic Dermatitis 74% * Therapeutics 11% ...

https://scholars.uky.edu/en/persons/xiaohua-zhang/publications/

Measurement of plasma specific IgE to Ascaris lumbricoides antigen and to Dermatophagoides pteronyssinus (house dust mite), ... Allergens, like helminth antigens [5, 6] are potent inducers of Th2 responses [7] and it is known that allergic diseases ... Skin prick test (SPT) reactivity to common aeroallergens [41] will be tested with extracts of Dermatophagoides pteronyssinus ... and Ascaris antigen (20 μg/ml as prepared by van Riet E et al [46]. Supernatants will be collected on day 1 (unstimulated ...

https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-11-83

Dermatophagoides farinae antigen f 1 Medicine & Life Sciences 19% View full fingerprint ...

https://augusta.pure.elsevier.com/en/publications/family-history-dust-mite-exposure-in-early-childhood-and-risk-for

Dermatophagoides farinae). When UCBC from Para-POS and Para-NEG newborns were exposed to helminth antigens or allergens ... The corneal lesions result from the host response to bacterial, viral (40% of cases) or parasitic antigens, or from an ... CSF was negative for cryptococcal antigen but wet mount preparation showed highly motile free living amoeba Naegleria fowleri. ... Prenatal exposure to parasite antigens or allergens will influence the profile and strength of postnatal immune responses, such ...

https://pesquisa.bvsalud.org/portal/?lang=es&q=mh:Amebiasis/complicaciones

The house dust mite (Dermatophagoides pteronyssinus) as a typical causative agent of perennial allergy, and the cedar pollen ... antigen as a typical causative agent of seasonal allergy were irradiated with the Streamer at different times. The inactivation ... As a typical causative agent of perennial allergy, the Streamer was irradiated to house dust mite (Dermatophagoides ...

https://www.daikinindia.com/decomposes-house-dust-mites-feces-and-carcasses-causes-perennial-allergic-symptoms

Erdr1 Attenuates Dermatophagoides farina Body Extract-Induced Atopic Dermatitis in NC/Nga Mice. Journal of Investigative ... class II on professional antigen-presenting cells with the T-cell receptor to induce T-cell activation independent of antigens ... We investigated whether Dermatophagoides farinae extract (DFE) allergens mediate innate immune activation through specific toll ...

https://www.jidonline.org/content/ad

T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are ... Adult, Antigens, Dermatophagoides, Antigens, Differentiation, T-Lymphocyte, Antigens, Neoplasm, Arthropod Proteins, Cysteine ... BACKGROUND: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and ...

https://www.rdm.ox.ac.uk/publications/19716

Antigen Sensitization to Der p1. *Der P1 found in Dust mite feces ... Dermatophagoides pteronyssinus. *Acaridae family (closely ...

https://fpnotebook.com/legacy/ENT/Allergy/DstMt.htm

Hepatitis B E Antigen - (HBEAG). Hepatitis B Surface Antigen (Hbsag) - Elisa. Hepatitis B Surface Antigen (Hbsag) - Spot / ... Allergy - Dermatophagoides Farinae. Allergy - Dermatophatgodies Pteronyssinus. Nor - Metanephrines - 24 hrs urine. Malarial ... Free Prostatic Specific Antigen (FPSA) Profile. Free Prostatic Specific Antigen (FPSA). Lymphocytes. Eosinophils. Monocytes. ... Dengue Antigen (NS1). Dengue Virus Antibody IgG. Dengue Virus Antibody IgM. Iron. fe. Postprandial Insulin. pp insulin. insulin ...

https://bloodoxy.com/view/product/Lab-Tests-Health-Checkup/Lab-Test/Free-Testosterone/BOBT00343?id=343

TYPE III Antigen antibody immune complexes. IgG mediated Immune Complex Disease • Large amount of antigen and antibodies form ... Dermatophagoides pteronyssinus (common dust mite). *. Der P1 Allergen Allergen is easily aerosolized and inhaled. Der P1 breaks ... Serum SicknessSystemic immune complex disease Large amounts of antigen such as injection of foreign serum. Days after Antigen ... TYPE IIHemolytic disease of newborn Rh factor incompatibility • IgG abs to Rh an innocuous rbc antigen • Rh+ baby born to Rh- ...

https://www.slideserve.com/donnagreer/hypersensitivity-powerpoint-ppt-presentation

https://m.pdr.net/drug-summary/Odactra-dermatophagoides-farinae-and-dermatophagoides-pteronyssinus-24190

... at baseline or following antigen challenge. These data identify IRF5-expressing macrophages as a key component of the immune ... Adoptive Transfer, Animals, Antigens, Dermatophagoides, Cell Movement, Cells, Cultured, Eosinophils, Extracellular Matrix, ... at baseline or following antigen challenge. These data identify IRF5-expressing macrophages as a key component of the immune ...

https://www.oncology.ox.ac.uk/publications/652704

In the mites Dermatophagoides pteronyssinus ( Tsai et al., 2005), D. farinae ( Tsai et al., 1999) and Blomia tropicalis ( Ramos ... into an exposed antigen. PRM was initially described as an internal muscular protein of invertebrates, but many parasites, ... indicus infested bovines developed IgG against rBmPRM as well as recognize salivary antigens at different levels, showing ... individual differences in antibody production against rBmPRM and salivary extract antigens. Serine protease inhibitor-3 (RMS-3 ...

https://agckinase.com/microplus-tissues-exposed-hosts-immune-system

https://www.staging.medscape.com/viewarticle/812906_3

An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the ... 4] with hypersensitivity to Dermatophagoides pteronyssinus. Some authorities have suggested that patients with eosinophilic ... 8] A selective migration of leukocyte factor antigen-1-positive eosinophils and lymphocytes to hair follicles may be explained ... Eosinophilic pustular folliculitis in three atopic children with hypersensitivity to Dermatophagoides pteronyssinus. ...

https://emedicine.staging.medscape.com/article/1070326-overview

Tissue antigens 2007 Sep 70 (3): 219-27. Spagnolo P, Sato H, Grutters J C, Renzoni E A, Marshall S E, Ruven H J T, Wells A U, ... Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der ... Tissue antigens 2007 Dec 70 (6): 480-6. Sato H, Spagnolo P, Silveira L, Welsh K I, du Bois R M, Newman L S, Maier L ... Tissue antigens 2007 Aug 70 (2): 128-35. Mochida A, Kinouchi Y, Negoro K, Takahashi S, Takagi S, Nomura E, Kakuta Y, Tosa M, ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Sarcoidosis+and+BTNL2&Mysubmit=Search

IgM is the first antibody raised in response to antigen exposure and its response to S. scabiei var. cuniculi was crucial to ... Resistance and immune response in scabies-infested hosts immunized with Dermatophagoides mites. Am J Trop Med Hyg. 1995;52:539- ... IgM was the first antibody to appear in response to the antigen exposure from S. scabiei var. cuniculi and our results showed ... HLA class II antigens are associated with resistance or susceptibility to hepatosplenic disease in a Chinese population ...

https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3764-5

[ 201 ] The most common are Bet v 1 ( Betula pendula or Birch pollen), Per h 1 ( Periplaneta americana or American cockroach), Der p 1 ( Dermatophagoides pteronyssinus or European house dust mite (HDM)) and Amb a 5 ( Ambrosia artemisiifolia or short ragweed). (medscape.com)
[ 36 , 37 ] Mannosylation is the most common glycosylation pattern among allergens with an exception of Der p 2 ( Dermatophagoides pteronyssinus or European HDM), which has N -acetylglucosamine, galactose and sialic acid. (medscape.com)
The subjects were prick tested with extracts of materials collected in the swine confinement building such as swine food, corn flour, swine hair, and bacterial, mold, and Dermatophagoides-pteronyssinus antigens. (cdc.gov)
Each tablet contains 12 SQ-HDM [6 SQ-HDM Dermatophagoides farinae and 6 SQ-HDM Dermatophagoides pteronyssinus], in a 1:1:1:1 potency ratio of D. farinae group 1 allergen, D. farinae group 2 allergen, D. pteronyssinus group 1 allergen, and D. pteronyssinus group 2 allergen. (pdr.net)
Antígenos de los ácaros del polvo doméstico (DERMATOPHAGOIDES), principalmente D. farinae y D. pteronyssinus. (bvsalud.org)
Antigens from the house dust mites ( DERMATOPHAGOIDES ), mainly D. farinae and D. pteronyssinus. (bvsalud.org)
As a typical causative agent of perennial allergy, the Streamer was irradiated to house dust mite (Dermatophagoides pteronyssinus) at different times. (daikinindia.com)
The house dust mite (Dermatophagoides pteronyssinus) as a typical causative agent of perennial allergy, and the cedar pollen antigen as a typical causative agent of seasonal allergy were irradiated with the Streamer at different times. (daikinindia.com)
In the mites Dermatophagoides pteronyssinus ( Tsai et al. (agckinase.com)

Antigens, which induce immune response, are called immunogens, and if they elicit allergies (type I hypersensitivity), they are referred to as allergens. (medscape.com)
More than 11 groups of Dermatophagoides ALLERGENS have been defined. (bvsalud.org)
Allergens are nonparasite antigens that can stimulate a type I hypersensitivity response. (slideserve.com)

Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der f) in Japanese. (cdc.gov)

House dust mites - Dermatophagoides farina , D. pteronysinus and possibly Blomia tropicalis and Euroglyphyus maynei . (vetlexicon.com)

[ 40 ] Apart from Der p 1, Bla g 2 ( Blattella germanica or German cockroach antigen), Can f 1 ( Canis familiaris or dog allergen) and Fel d 1 ( Felis domisticus or cat allergen) are mannosylated with 1-2, 1-3 and 1-6 mannose. (medscape.com)

BACKGROUND: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease. (ox.ac.uk)

As soon as the immune system is established early in the infancy and childhood, DCs start on sampling antigens in the cellular environment around basement membrane. (medscape.com)

2001). The data presented herein showed that both B. taurus and B. indicus infested bovines developed IgG against rBmPRM as well as recognize salivary antigens at different levels, showing individual differences in antibody production against rBmPRM and salivary extract antigens. (agckinase.com)

Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-depend- ent antibodies, including IgE. (cdc.gov)
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. (revistabiomedica.org)

[ 8 ] A selective migration of leukocyte factor antigen-1-positive eosinophils and lymphocytes to hair follicles may be explained by intercellular adhesion molecule-1 expression by keratinocytes on follicular epithelium but not on epidermis. (medscape.com)

Antigens, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "Antigens, Bacterial" by people in this website by year, and whether "Antigens, Bacterial" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Antigens, Bacterial" by people in Profiles. (wakehealth.edu)

Adoptive transfer of IRF5-deficient alveolar macrophages into the wild-type pulmonary milieu was sufficient to drive airway hyperreactivity, at baseline or following antigen challenge. (ox.ac.uk)

CusabioRat rotavirus (RV) antigen (Ag) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is. (joplink.net)

Antigen-presenting cells stimulate the production of T helper 2 cells both locally and at distant lymph nodes → stimulate IgE-producing B cells, producing interleukins → mast cell and eosinophil. (vetlexicon.com)

CusabioAlternative Name(s): B-cell maturation protein (CD_antigen: CD269) (Bcm). (joplink.net)

Antigen Laboratories, Inc. (drugbank.com)

An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the pathogenesis of HIV-associated eosinophilic pustular folliculitis (see the image below). (medscape.com)

Tissue antigens 2007 Aug 70 (2): 128-35. (cdc.gov)
Tissue antigens 2007 Sep 70 (3): 219-27. (cdc.gov)
Tissue antigens 2007 Mar 69 (3): 236-41. (cdc.gov)
Tissue antigens 2007 Dec 70 (6): 480-6. (cdc.gov)
Tissue antigens 2009 Jan 73 (1): 59-61. (cdc.gov)

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (nih.gov)

Tracheal explants from male Hartley-guinea-pigs were incubated with 0 to 100 microliters of a extract of a mixture of swine hair, pig food, and swine confinement building antigens. (cdc.gov)

Availability of diverse DCs at various sites of antigen exposure or immune invasion depends on many factors. (medscape.com)

Son proteínas que se encuentran en las heces o los extractos de ácaros y pueden causar ASMA y otras enfermedades alérgicas, como la RINITIS ALÉRGICA PERENNE y la DERMATITIS ATÓPICA. (bvsalud.org)

The two fungal antigens ( Alternaria alternata and Aspergillus fumigatus ) measured are primarily outdoor antigens, which are transported into the indoor environment. (cdc.gov)

Fourteen swine farm ers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. (cdc.gov)
The swine workers with positive skin reactions to swine confinement antigens had a higher prevalence of chronic cough, phlegm, and bronchitis than those with negative results. (cdc.gov)

A double masked randomised trial comparing 0.05% mequitazine eye drops with 0.05% levocabastine and placebo was carried out in otherwise heatlhy volunteers allergic to house dust mites ( Dermatophagoides pteronyssinus ). (bmj.com)
dust mites (dermatophagoides farani) - walk amongst dust on black surface - dust mite bildbanksvideor och videomaterial från bakom kulisserna Dust mite allergy, also known as house dust allergy, is a sensitization and allergic reaction to the droppings of house dust mites.The allergy is common and can trigger allergic reactions such as asthma, eczema or itching. (netlify.app)
The host response is typical of an immediate hypersensitivity reaction however, there has been little definition of the antigens present in the mites to date. (ed.ac.uk)
The major allergen in house dust remained obscure until 1967, when it was suggested that the most important source of house dust allergy was mites belonging to the genus Dermatophagoides (Figure). (protechallergies.com)

They help the immune system to destroy the antigen by creating a bridge for other proteins to attach to the antigen and attack it. (giantmicrobes.com)

Uehara K, Toyoda Y, Konishi E. Contamination of passenger trains with Dermatophagoides (Acari: Pyroglyphidae) mite antigen in Japan. (aaem.pl)

Infant rhesus monkeys received episodic exposure to O 3 biweekly with or without house dust mite antigen (HDMA) from 6 to 12 months of age. (elsevier.com)
Cockroach and mite extracts contain digestive enzymes while moulds and insects contain proteases which can denature other antigens. (allergyasthma.on.ca)
Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. (unipune.ac.in)

Using an Elispot method the cytokines profile of PBMC stimulated with nickelsulfate (NiSO4), D1 antigen (a.D1) of Dermatophagoides pteronyssinus and staphylococcal enterotoxins (SEA, SEB) in vitro in an acute and chronic phases of atopic dermatitis (AD) and in controls (healthy volunteers) was investigated. (krakow.pl)

Eosinophilic pustular folliculitis has been described in atopic children[4] with hypersensitivity to Dermatophagoides pteronyssinus. (medscape.com)

The two fungal antigens ( Alternaria alternata and Aspergillus fumigatus ) measured are primarily outdoor antigens, which are transported into the indoor environment. (cdc.gov)

The complex formed by the binding of antigen and antibody molecules. (bvsalud.org)
The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES . (bvsalud.org)

Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-depend- ent antibodies, including IgE. (cdc.gov)
Sites on an antigen that interact with specific antibodies. (uchicago.edu)
While the bodies of antibodies come in a few specific types (or isotypes), the tips (or paratopes) can be custom made, like a lock to a key, to attach only to specific parts (or epitopes) of an antigen. (giantmicrobes.com)
Sometimes a single antigen has a number of epitopes - which means it gets tackled by a swat team of antibodies, giving it little chance of escape. (giantmicrobes.com)

Antigens, Neoplasm" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "Antigens, Neoplasm" by people in this website by year, and whether "Antigens, Neoplasm" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Antigens, Neoplasm" by people in Profiles. (wakehealth.edu)

Among strategies that promote antigen immunogenicity are those that render vaccine antigens particulate, those that polymerize or emulsify vaccine antigens, methods of encapsulating vaccine antigens, ways of increasing host immune responses, and methods that target vaccine antigens to antigen presenting cells (Nossal, 1999, In: Fundamental Immunology. (justia.com)

An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the pathogenesis of HIV-associated eosinophilic pustular folliculitis (see the image below). (medscape.com)
Vaccination is a medical treatment intended to induce an immune response against antigens present in the vaccine. (justia.com)
One factor that limits the activity of current vaccines is insufficient retention of the antigen in the host: resulting in poor targeting to lymph nodes-where immune responses are primed, and insufficient response to the antigen to protect against the disease. (justia.com)
There is, therefore, a need for novel vaccine compositions that provide sufficient exposure to the antigen for an effective immune response and for compositions that increase safety and stability of the vaccine. (justia.com)
The present disclosure, is based, at least in part on a surprising discovery that by site-specific engineering of the interaction between antigens and aluminum hydroxide (alum), an immune response to the antigenis enhanced. (justia.com)
Accordingly, in some aspects, the disclosure provides a method to increase an immune response to an antigen in a subject, wherein the antigen is modified to provide site-specific and/or tight binding to a metal hydroxide adjuvant (e.g., alum) via one or more PS residues. (justia.com)
Poly(lactic-co-glycolic acid) (PLGA) particles carrying antigen and adjuvant is a promising vaccine system which has been shown to stimulate systemic antigen-specific immune responses. (jijitang.com)
In this study, we investigated the relationship of (i) the sizes of PLGA particle and (ii) the presence of cytosine-phosphate-guanine motifs (CpG), with the extent and type of immune response stimulated against Dermatophagoides pteronyssinus-2 (Der p2) antigen. (jijitang.com)
The adaptive immune system develops its antigen specificity repertoire through controlled somatic recombination processes and can respond with exquisite specificity to a wide variety of antigen types. (justia.com)
Two critical limitations remain: (1) properly priming innate immune cells with the right signals delivered at the optimal time and in optimal ratios to safely boost their function while also providing a suitable environment for inducing an adaptive immune response, and (2) identifying the right antigen or combination of antigens that should be targeted by the adaptive response. (justia.com)
At present, compounds that are used in the clinic are bulk mixtures of immune stimulants, optionally combined with antigens, which have been empirically determined to induce innate and adaptive immune responses, respectively. (justia.com)
Secreted by specialized B-cells, they function by grabbing onto suspicious antigens using the tips of their arms, and holding fast until other immune system cells have a chance to neutralize the threat. (giantmicrobes.com)

In addition to cockroach enzymes, among the moulds, alternaria, cladosporium, aspergillus, helminthosporium and penicillium are known to have protease activity that can interfere with the potency of other antigens in a mixture. (allergyasthma.on.ca)

P less than 0.050), after local instillation of the antigen. (nih.gov)
These studies provide evidence that the release of prostaglandin D2 into the airways is an early event after the instillation of D. pteronyssinus in patients who are sensitive to this antigen. (nih.gov)

We performed bronchoalveolar lavage in five patients with chronic stable asthma, before and up to nine minutes after local provocative challenge with Dermatophagoides pteronyssinus. (nih.gov)

Levels of 15-hydroxyeicosatetraenoic acid, which may also have a role in the pulmonary allergic response, were detectable in lavage fluid before challenge and increased after provocation with the antigen in four of the five patients. (nih.gov)

The present disclosure relates to compositions and methods for coupling an antigen to an adjuvant, immunogenic compositions and vaccines. (justia.com)
and (b) a metal hydroxide adjuvant (e.g., alum), wherein the antigen is conjugated to the metal hydroxide adjuvant via the hydroxyl replacement groups of the multivalent adjuvant-reactive moiety, thereby forming an antigen-adjuvant complex. (justia.com)
In some aspects, the antigen is conjugated to a metal hydroxide adjuvant (e.g., alum) via one or more phosphorylated amino acid residues, such as one or more phosphoserine (PS) residues. (justia.com)
In some aspects, the disclosure provides methods and compositions comprising antigens modified to provide tight binding to a metal hydroxide adjuvant (e.g., alum) through a site-specific introduction of multivalent PS peptide-polymer affinity linkers, which undergo ligand exchange reactions with the surface of alum to anchor antigens in an site-specific and/or surface oriented manner on the metal hydroxide adjuvant, such as alum. (justia.com)

Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (bvsalud.org)

House Dust is not specific and contains innumerable and indefinable antigens. (allergyasthma.on.ca)

Accordingly, the present disclosure provides immunogenic compositions for eliciting enhanced humoral immunity to antigens of interest, thereby providing improved vaccines. (justia.com)

CD14/-159 plays a role in sensitization to Dermatophagoides pteronyssinus in Japanese patients with allergic rhinitis. (nih.gov)
investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. (nt-4.com)

Using human leukocyte antigen-A*0201-peptide (HLA-A*0201-peptide) tetrameric complexes and enzyme-linked immunospot assays to analyze peripheral blood mononuclear cells from A*0201-positive severely symptomatic atopics, asymptomatic atopics, and nonatopic controls, we observed a significant association between the frequency of the Der p 1-specific CD8(+) T cells and disease activity. (ox.ac.uk)

The specific T cells expressed an antigen-experienced cell surface phenotype, and 45.7% were positive for cutaneous lymphocyte-associated antigen. (ox.ac.uk)
There are amino acid chains on the ends of the Y that attach like puzzle pieces to a specific harmful substance, called an antigen. (giantmicrobes.com)

To a certain extent, the use of standardized antigens will help to assure that a single batch will be consistent from vial to vial as long as the manufacturer is the same, but this does not necessarily apply from one manufacturer to another. (allergyasthma.on.ca)

Fourteen swine farmers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. (cdc.gov)

Compatibility of mixed antigens is not always present. (allergyasthma.on.ca)

The first is to coat the antigen in order to prevent it from hurting the healthy body cells. (giantmicrobes.com)

Anatomy5

Organisms9

Diseases11

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes5

Technology, Industry, Agriculture2

Information Science3

Health Care2

Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence. (1/409)

Production of recombinant Der fI (a major mite allergen) by Aspergillus oryzae. (2/409)

Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae. (3/409)

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (4/409)

Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. (5/409)

Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. (6/409)

Role of allergy in nasal polyps of Thai patients. (7/409)

Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p I allergen-induced animal model of airway inflammation. (8/409)

Dermatophagoides farinae

Antigens, Dermatophagoides

Dermatophagoides pteronyssinus

Mites

Arthropod Proteins

Allergens

Pyroglyphidae

Immunoglobulin E

Antigens

Skin Tests

Rhinitis, Allergic, Perennial

Mite Infestations

Dust

Hypersensitivity

Hypersensitivity, Immediate

Radioallergosorbent Test

Antigens, Bacterial

Desensitization, Immunologic

Antigens, Neoplasm

Asthma

Antigens, Surface

Acaridae

Sarcoptes scabiei

Antigens, Viral

Scabies

Dermatitis, Atopic

Glycoproteins

Intradermal Tests

Cysteine Endopeptidases

Cockroaches

Immunoglobulin G

Nasal Provocation Tests

Administration, Sublingual

Respiratory Hypersensitivity

Antigens, Plant

Blattellidae

Floors and Floorcoverings

Conjunctivitis, Allergic

Enzyme-Linked Immunosorbent Assay

Bronchial Provocation Tests

Antigens, Protozoan

Cross Reactions

Basophil Degranulation Test

Antigens, Polyomavirus Transforming

Epitopes

HLA Antigens

Antibody Specificity

Antigens, Fungal

T-Lymphocytes

Immunization

Antigens, CD

Antigens, Helminth

Bedding and Linens

H-2 Antigens

Molecular Sequence Data

Rhinitis, Allergic, Seasonal

Basophils

Oils, Volatile

Mice, Inbred BALB C

Carcinoembryonic Antigen

Amino Acid Sequence

Antigens, Viral, Tumor

Interleukin-5

Interleukin-4

Th2 Cells

Lymphocyte Activation

Bronchial Hyperreactivity

HLA-DR Antigens

Receptors, Antigen, T-Cell

Pollen

Histocompatibility Antigens

Antibodies, Monoclonal

Proliferating Cell Nuclear Antigen

Interferon-gamma

Air Pollution, Indoor

Cytokines

Histocompatibility Antigens Class II

Prostate-Specific Antigen

O Antigens

Receptors, Antigen, B-Cell