Species of American house dust mite, in the family PYROGLYPHIDAE.
Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.
Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Substances that are recognized by the immune system and induce an immune reaction.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
Infestations with arthropods of the subclass ACARI, superorder Acariformes.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.
Substances elaborated by bacteria that have antigenic activity.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.
A species of mite that causes SCABIES in humans and sarcoptic mange in other animals. Specific variants of S. scabiei exist for humans and animals, but many have the ability to cross species and cause disease.
Substances elaborated by viruses that have antigenic activity.
A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Skin tests in which the sensitizer is injected.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.
Administration of a soluble dosage form by placement under the tongue.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Substances found in PLANTS that have antigenic activity.
A family of insects in the order Dictyoptera (COCKROACHES), including genera Blattella, Parcoblatta, and Symploce.
The surface of a structure upon which one stands or walks.
Conjunctivitis due to hypersensitivity to various allergens.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Sites on an antigen that interact with specific antibodies.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Substances of fungal origin that have antigenic activity.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Articles of cloth, usually cotton or rayon and other synthetic or cotton-blend fabrics, used in households, hospitals, physicians' examining rooms, nursing homes, etc., for sheets, pillow cases, toweling, gowns, drapes, and the like.
The major group of transplantation antigens in the mouse.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
The fertilizing element of plants that contains the male GAMETOPHYTES.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antibodies produced by a single clone of cells.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The contamination of indoor air.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Proteins prepared by recombinant DNA technology.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence. (1/409)

BACKGROUND: Relatively little is known about risk factors for the persistence of asthma and respiratory symptoms from childhood into adolescence, and few studies have included objective measurements to assess outcomes and exposure. METHODS: From a large cross sectional study of all 4th grade school children in Munich (mean age 10.2 years), 234 children (5%) with active asthma were identified. Of these, 155 (66%) were reinvestigated with lung function measurements and bronchial provocation three years later (mean age 13.5 years). RESULTS: At follow up 35.5% still had active asthma. Risk factors for persisting asthma symptoms in adolescence were more severe asthma (OR 4.94; CI 1.65 to 14.76; p = 0.004) or allergic triggers (OR 3.54; CI 1.41 to 8.92; p = 0.007) in childhood. Dampness was associated with increased night time wheeze and shortness of breath but not with persisting asthma. Risk factors for bronchial hyperreactivity in adolescence were bronchial hyperreactivity in childhood (p = 0.004), symptoms triggered by allergen exposure (OR 5.47; CI 1.91 to 25.20; p = 0.029), and damp housing conditions (OR 16.14; CI 3.53 to 73.73; p < 0.001). In a subgroup in whom house dust mite antigen levels in the bed were measured (70% of the sample), higher mite antigen levels were associated with bronchial hyperreactivity (OR per quartile of mite antigen 2.30; CI 1.03 to 5.12; p = 0.042). Mite antigen levels were also significantly correlated with dampness (p = 0.05). However, the effect of dampness on bronchial hyperreactivity remained significant when adjusting for mite allergen levels (OR 5.77; CI 1.17 to 28.44; p = 0.031). CONCLUSION: Dampness at home is a significant risk factor for the persistence of bronchial hyperreactivity and respiratory symptoms in children with asthma. This risk is only partly explained by exposure to house dust mite antigen.  (+info)

Production of recombinant Der fI (a major mite allergen) by Aspergillus oryzae. (2/409)

Der fI is a major mite allergen. To produce Der fI by Aspergillus oryzae, we placed a DNA fragment encoding precursor-type recombinant Der fI E(-1)K (reDer fI E(-1) K), which had the C-terminal amino acid of the pro-sequence (Glu) changed to Lys, downstream of the glaA gene promoter and introduced it into Aspergillus oryzae. In liquid culture, most of the reDer fI E(-1)K produced by the transformants was degraded when culture was shaken vigorously. However, the degradation of reDer fI E(-1)K was suppressed when it was shaken gently. The processed reDer fI E(-1)K could be obtained after lysylendopeptidase and endoglycosidase Hf (Endo Hf) treatment. The yield of processed reDer fI E(-1)K was 8 mg/l. When the transformant was grown on a wheat bran culture, the yield of processed reDer fI E(-1)K reached 48 mg/kg. Because processed reDer fI E(-1)Ks obtained from both cultures had almost the same IgE-binding activity and elicited the same skin reaction as native Der fI, they could be very useful for diagnostic purposes or immunotherapy.  (+info)

Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae. (3/409)

House dust mite allergen is thought to be a major cause of asthma. Characterization of these allergen molecules is therefore an important step for the development of effective diagnostic and therapeutic agents against mite-associated allergic disorders. Here we report molecular cloning and expression of the group 6 (chymotrypsin-like) allergen from the house dust mite, Dermatophagoides farinae. Sequencing analysis indicates that cloned cDNA, designated Der f 6, encodes a 279 amino acid polypeptide which conserves a primary structure characteristic for chymotrypsin-like serine proteases found in mammals. Recombinant Der f 6 expressed in Escherichia coli bound IgE in a pool made of 20 sera, and induced histamine release from patients' peripheral blood cells.  (+info)

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (4/409)

House dust mite (HDM) allergens are important factors in the increasing prevalence of asthma. The lung epithelium forms a barrier that allergens must cross before they can cause sensitization. However, the mechanisms involved are unknown. Here we show that the cysteine proteinase allergen Der p 1 from fecal pellets of the HDM Dermatophagoides pteronyssinus causes disruption of intercellular tight junctions (TJs), which are the principal components of the epithelial paracellular permeability barrier. In confluent airway epithelial cells, Der p 1 led to cleavage of the TJ adhesion protein occludin. Cleavage was attenuated by antipain, but not by inhibitors of serine, aspartic, or matrix metalloproteinases. Putative Der p 1 cleavage sites were found in peptides from an extracellular domain of occludin and in the TJ adhesion protein claudin-1. TJ breakdown nonspecifically increased epithelial permeability, allowing Der p 1 to cross the epithelial barrier. Thus, transepithelial movement of Der p 1 to dendritic antigen-presenting cells via the paracellular pathway may be promoted by the allergen's own proteolytic activity. These results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens.  (+info)

Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. (5/409)

A positive lymphocyte transformation test to beta-lactams (beta-L) was found in 12 of 29 subjects with adverse drug reaction (ADR) to beta-L, irrespective of either the type of clinical manifestation or the presence of specific serum IgE. Short-term T cell lines specific for penicillin G, amoxicillin, and ampicillin could be generated only from subjects with ADR (eight with positive and one with negative lymphocyte transformation test), while streptokinase and Dermatophagoides pteronyssinus group 1 (Der p 1)-specific T cells were obtained from all these subjects, from 7 atopic Der p-sensitive donors without history of ADR and 17 healthy nonatopic donors. Streptokinase-specific T cells from all subjects showed intracellular expression of IFN-gamma with poor or no IL-4, whereas Der p 1-specific T cells exhibited IFN-gamma but low or no IL-4 expression in nonatopics, and remarkable IL-4 expression in atopic donors. By contrast, all penicillin G-, ampicillin-, and amoxicillin-specific short-term T cell lines showed high intracellular expression of IL-4, IL-5, and IL-13, but poor or no expression of IFN-gamma, thus exhibiting a clear-cut Th2 profile. Accordingly, most penicillin G-specific T cell clones derived from two subjects with ADR released high concentrations of IL-4 alone or IL-4 and IFN-gamma. These data suggest that cytokines produced by Th2 cells play an important role in all beta-L-induced ADR, even when late clinical manifestations occur and an IgE-mediated mechanism is apparently indemonstrable.  (+info)

Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. (6/409)

Sensitization towards a panel of eight regional inhalant allergens was evaluated among 107 patients with allergic rhinitis and/or asthma. A total of 32 children (age 5-13 years, mean 9 years; 18 male, 14 female), 75 adolescents and adults (aged 14-66 years, mean 32 years; 21 male, 54 female) and 20 normal control volunteers (aged 16-46, mean 30 years; 4 male, 16 female) were evaluated via skin prick test. A weal response of 3 x 3 mm or greater was taken to be positive. The sensitization rates among individuals to these allergens were: house dust mites, Dermatophagoides pteronyssinus (77.57%), Blomia tropicalis (71.96%), Austroglycyphagus malaysiensis (33.64%), pollen, palm oil Elaeis guineensis (22.43%), Acacia auriculiformis (12.15%), fern spore, resam Dicranopteris spp (11.21%), fungal spores: Curvularia fallax (8.41%) and Exserohilum rostratum (13.08%). There were significantly higher frequencies of sensitization to these allergens among allergic individuals compared to normal controls, and among atopic individuals with two allergy manifestations (rhinitis and asthma) compared to those with only one. No difference was noted between children and adults in the allergic group. In conclusion, the allergic patients were highly sensitized to dust mites and sensitization to regional pollen and spores was also documented. They should be considered as relevant and be included in skin test batteries in Indonesia.  (+info)

Role of allergy in nasal polyps of Thai patients. (7/409)

As distinct from many countries, allergy in Thailand is of the perennial type which may play a role in the formation of nasal polyps. Forty consecutive patients with nasal polyps and 30 normal subjects as control were studied at the Allergy Clinic, Department of Otolaryngology, Pramongkutklao Hospital. A positive clinical history and skin allergy testing are diagnostic criteria for allergy. In the nasal polyps group, these were 28 males and 12 females, aged between 12-65 years, with an average age of 38.5 years. In the control group, there were 18 males and 12 females, aged between 15-53 yeas, with an average age of 34 years. All had received prick skin testing with 6 common aeroallergens. The prick skin test was considered positive when the wheal was > or = 3 mm with surrounding erythema. Twenty-four of 40 patients (60%) with nasal polyps had a positive prick skin test, while 6 in the 30 control cases (20%) had a positive prick skin test. This difference was statistically significant (P = 0.0019), Odd's ratio = 6.0 which means allergic persons were 6 times more prone to have polyps form than normal persons.  (+info)

Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p I allergen-induced animal model of airway inflammation. (8/409)

Interleukin-12 (IL-12) is a key cytokine, which promotes T helper type 1 (Th1) cell-mediated immunity and inhibits Th2-type responses. It has been previously shown that IL-12 administration during active immunization following a single allergen exposure can prevent antigen-induced increases in immunoglobulin E (IgE) formation, Th2 cytokine production and bronchoalveolar lavage (BAL) eosinophils in a murine model of allergic airway inflammation. Thus, these studies have now been extended and two IL-12 treatment protocols on this murine model were evaluated. Administration of IL-12 during the active immunization strikingly increased Der p I-specific serum IgG2a and transiently decreased the levels of IgG1 and IgE antibodies following multiple allergen challenges. Such early treatment of IL-12 down-regulated IL-5 production and modestly up-regulated interferon-gamma production but did not effect BAL eosinophilia. These results suggest that repeated exposure to antigen and IL-12 is necessary to maintain a persistent Th1-recall response. Furthermore, administration of IL-12 to actively immunized mice, in which Th2-associated responses were established, had a significant effect on IgG2a synthesis and a modest effect on IgE levels, also down-regulation of IL-5 production, and markedly increased interferon-gamma production and abolished recruitment of eosinophils. Therefore, these data indicate that IL-12 can inhibit antigen-induced eosinophil infiltration into airways, despite the existence of a Th2-associated response. Taken together, these studies suggest that IL-12 may be useful as an immunotherapeutic agent in the treatment of such pulmonary allergic disorders as bronchial asthma.  (+info)

Dust Mite Allergen Der F 8 Promotes Th2 Polarization via Modulating Chromatin Structure at the TIM4 Gene Locus in Dendritic Cells Abstract.
IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I.: Large peptides expressed from cDNA fragme
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ERKRANKUNGEN DER HORNHAUT BN ERKRANKUNGEN DER HORNHAUT 2. Funktion 2.1 Transparenz: Tränenfilm, reguläre Kollagenstruktur, relative Dehydratation 2.2 dioptrische Eigenschaften Krümmungsradius: 7,8 mm Durchmesser: horizontal: 11,7 mm; vertikal: 10,6 mm Dicke: zentral: 0,5 mm; peripher: 0,8 mm Brechungsindex: 1, Brechkraft: Vorderfläche: +48 Dpt.; Rückfläche: -5 Dpt.; Gesamtbrechkraft: 43 Dpt.
To establish whether allergic asthma could be induced experimentally in a nonhuman primate using a common human allergen, three female rhesus monkeys (Macaca mulatta) were sensitized with house dust mite (Dermatophagoides farinae) allergen (HDMA) by subcutaneous injection, followed by four intranasal sensitizations, and exposure to allergen aerosol 3 hours per day, 3 days per week for up to 13 weeks. Before aerosol challenge, all three monkeys skin-tested positive for HDMA. During aerosol challenge with HDMA, sensitized monkeys exhibited cough and rapid shallow breathing and increased airway resistance, which was reversed by albuterol aerosol treatment. Compared to nonsensitized monkeys, there was a fourfold reduction in the dose of histamine aerosol necessary to produce a 150% increase in airway resistance in sensitized monkeys. After aerosol challenge, serum levels of histamine were elevated in sensitized monkeys. Sensitized monkeys exhibited increased levels of HDMA-specific IgE in serum, ...
Background: Der f 7 is the group 7 allergen from the dust mite Dermatophagoides farinae, homologous to the major allergen Der p 7 from D. pteronyssinus. Monoclonal antibody that bind to residues Leu48 and Phe50 was found to inhibit IgE binding to residue Asp159, which is important for the cross-reactivity between Der f 7 and Der p 7. Methodology/Principal Findings: Here, we report the crystal structure of Der f 7 that shows an elongated and curved molecule consisting of two anti-parallel β-sheets - one 4-stranded and the other 5-stranded - that wrap around a long C-terminal helix. The overall fold of Der f 7 is similar to Der p 7 but key difference was found in the β1-β2 loop region. In Der f 7, Leu48 and Phe50 are in close proximity to Asp159, explaining why monoclonal antibody binding to Leu48 and Phe50 can inhibit IgE binding to Asp159. Both Der f 7 and Der p 7 bind weakly to polymyxin B via a similar binding site that is formed by the N-terminal helix, the 4-stranded β-sheet and the ...
TY - JOUR. T1 - Involvement of xanthine oxidoreductase-related oxidative stress in a Dermatophagoides farinae-induced asthma model of NC/Nga mice. AU - Setiawan, Heri. AU - Nagaoka, Kenjiro. AU - Kubo, Masayuki. AU - Fujikura, Yoshihisa. AU - Ogino, Keiki. PY - 2016. Y1 - 2016. N2 - Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as a source of the superoxide anion radical (O2 -) in oxidative stress associated with asthma has not yet been examined in detail. Here we investigated pathophysiological changes in XOR in an experimental model of asthma induced by the house dust mite Dermatophagoides farinae (Df). In the lungs of Df-treated mice, the production of O2 - from XOR increased and the nitrite concentrations decreased, whereas the protein expression of XOR remained unchanged. Moreover, the protein expression levels of XOR and the hydrogen peroxide (H2O2) concentrations in bronchoalveolar lavage fluid (BALF) were higher in ...
Allergens/*immunology, Animals, Antigens; Dermatophagoides/*immunology, Bronchoalveolar Lavage Fluid/immunology, Desensitization; Immunologic, Disease Models; Animal, Female, Immunoglobulin E/immunology, Kidney/immunology/pathology, Leukocytes, Liver/immunology/pathology, Mice, Mice; Inbred C57BL, Mites/*immunology, Pneumonia/*immunology/pathology, Pulmonary Eosinophilia/immunology/pathology, Radioallergosorbent Test, Research Support; Non-U.S. Govt, Respiratory Hypersensitivity/*immunology/pathology, Selenium Radioisotopes ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT1R) are widely used to treat asthma and allergic rhinitis, with variable response rates. Alveolar macrophages express UDP-specific P2Y6 receptors that can be blocked by off-target effects of CysLT1R antagonists. Sensitizing intranasal doses of an extract from the house dust mite Dermatophagoides farinae (Df) sharply increased the levels of UDP detected in bronchoalveolar lavage fluid of mice. Conditional deletion of P2Y6 receptors before sensitization exacerbated eosinophilic lung inflammation and type 2 cytokine production in response to subsequent Df challenge. P2Y6 receptor signaling was necessary for dectin-2-dependent production of protective IL-12p40 and Th1 chemokines by alveolar macrophages, leading to activation of NK cells to generate IFN-γ. Administration of CysLT1R antagonists during sensitization blocked UDP-elicited potentiation of IL-12p40 production by macrophages in vitro, suppressed the Df-induced production of ...
Sensitization to house dust mites (HDM) is highly prevalent among the young atopic population in Singapore. Previously published data suggest that individuals with skin allergies show preferred sensitization to Dermatophagoides pteronyssinus while individuals with pure respiratory allergies show preferred sensitization to Blomia tropicalis. The aim of our study was to compare the sensitization profiles between children with asthma and those with eczema to D. pteronyssinus and B. tropicalis and their specific allergens. A total of 60 children, 30 with asthma and 30 with eczema were recruited. IgE levels specific for a panel of HDM allergens from the two mite species were measured using enzyme-linked immunosorbent assay. The asthma group showed highest sensitization to Blo t5 while the eczema group showed highest sensitization to Der p5. Comparison between the two disease groups showed that the eczema group had significantly higher IgE levels for Der p (p=0.042) and its allergens Der p1 (p=0.019) ...
Cloning, expression, and characterization of Der f 7, an allergen of Dermatophagoides farinae from China. - Yu-bao Cui, Hong-xing Cai, Ying Zhou, Cui-xiang Gao, Wei-hong Shi, Ming Yu, Li Li
LONDON--(BUSINESS WIRE)-- Stallergenes Greer, a biopharmaceutical company specialising in treatments for respiratory allergies, announces the submission of a marketing authorisation application for STAGR320, its sublingual house dust mite (HDM) immunotherapy (SLIT) tablet, via a European decentralized procedure.
The scientists found that IgE-antibodies against three dust mite molecules (Der p 1, Der p 2 and Der p 23) appeared very early in the childrens blood, often before the onset of their disease. In some (but not all) children, this first step was followed by a cascade of events involving other mite molecules, through a phenomenon defined as molecular spreading. Children producing IgE to many molecules (polymolecular sensitization) had a higher risk of developing allergic rhinitis and asthma. Earlier onset of allergic sensitization, high exposure to house dust mite allergens, and having one or both parents affected by hay fever increased the risk of polymolecular sensitization. Interestingly, healthy pre-school children showing IgE antibodies to Der p 1 or Der p 23 developed more frequently asthma at school age. These and other molecules may be used for disease prevention in early life and to precisely tailor allergen immunotherapy in pediatric and adult patients ...
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A cDNA clone coding for a mite allergen of mol wt approximately 14,000 has been isolated and its DNA sequence determined. The native component from mite extracts encoded by this DNA was identified by immunoprobing blots of mite body extract with human IgE eluted from the electroblotted cloned fusion polypeptides derived from the expressed cDNA clone. The clone encodes a polypeptide with a deduced mol wt of 17,460. The deduced amino acid sequence was not homologous to any known protein sequences and it contains no cysteine or tryptophan. On blots, 21 of 38 sera from mite-allergic subjects recognized the cloned material, and this recognition strongly correlated with IgE-binding to the native component on protein blots of mite extract. ...
House dust mites are small arthropods that produce proteins-found in their feces, body parts, and eggs-that are major triggers of human allergies …
T Die Abgeurteilten des Volksgerichtshofs: eine Analyse der sozialen Merkmale %A Grimm, Holger %A Lauf, Edmund %J Historical Social Research %N 2 %P 33-52 %V 19 %D 1994 %@ 0172-6404 %= 2008-11-27T13:21:00Z %~ GESIS %, https://nbn-resolving.org/urn:nbn:de:0168-ssoar-32650 %X In mehr als 7.000 Verfahren wurden annähernd 17.000 Menschen durch den Volksgerichtshof zwischen 1934 und 1945 verurteilt. Der vorliegende Beitrag untersucht 90 Prozent der Akten (6.557 Verfahren mit 15.067 Verurteilten) daraufhin, ob ein spezifisches Sozialprofil der Abgeurteilten zu erkennen ist. Die Ergebnisse zeigen, daß alle Bevölkerungsgruppen vertreten sind. In der Vorkriegszeit dient der Volksgerichtshof als Machtsicherungsgericht. Außenpolitische Ziele prägen die gesamte Kriegszeit und erst in der Endphase dominieren wieder innenpolitische Zwecke. Auffallend ist, daß die Sozialstruktur der Verurteilten Ähnlichkeiten zu der damaligen Verteilung der unpolitisch motivierten Kriminalität aufweist. Passend zu ...
Januar 1891 zu Köln, war en däitsche Maschinnebauer an den Erfinder vum Ottomotor. Holzhausen an der Haide in EMS.svg 258 × 258; 231 KB. Cant-miss spots to dine, drink, and feast. Lakosainak száma 1182 fő (2019. szeptember 30. Holzhausen an der Haide Vacation Packages, 5-stars Hotels in Holzhausen an der Haide, 4-stars Hotels in Holzhausen an der Haide, 3-stars Hotels in Holzhausen an der Haide. Media in category Holzhausen an der Haide The following 5 files are in this category, out of 5 total. Holzhausen an der Haide este o comună din landul Renania-Palatinat, Germania Acest articol despre o localitate din Renania-Palatinat este un ciot. An Holzhausen an der Haide amo in usa ka munisipalidad ha distrito han Rhein-Lahn-Kreis, ha Rhineland-Palatinate, Alemanya Usa ka turók ini nga barasahon. Places to see, ways to wander, and signature experiences. Watch Queue Queue Holzhausen an der Haide Air Quality Index (AQI) is now Moderate. If you are a resident of another country or region, ...
article{1676ce13-860e-4b7c-b6d8-dbd15381e70d, author = {Enkvist, Inger}, issn = {1101-2412}, language = {swe}, month = {10}, pages = {5--5}, publisher = {Svenska Dagbladet}, series = {Svenska Dagbladet}, title = {Åtgärder som inte löser problemen}, url = {http://www.svd.se/opinion/ledarsidan/regeringens-atgarder-loser-inte-problemen-i-skolan_4054869.svd}, year = {2014 ...
Se opslaget i text version:. Kære Kandidatstuderende. Jeg søger 2 studerende, der kunne tænke sig at lave kandidatspeciale indenfor endokrinologi på forårssemestret 2021. Data egner sig til stort forskningskandidatspeciale (25 ECTS point). Det forventes at data vil kunne publiceres med den kandidatstuderende som 1. forfatter. Titlerne er. Klinisk og paraklinisk effekt af binyrebarkhormonbehandling af kvindelige patienter med 21-hydoxylasemangel behandlet på endokrinologisk afdeling Rigshospitalet.. Adrenogenitalt syndrom forårsaget af 21-hydroxylase mangel er sjælden arvelig sygdom der påvirker binyrernes evne til at producerer hormoner. Der er nedsat produktion af stres hormonet kortisol, og øget produktion af andre binyrehormoner herunder mandlige kønshormoner. For at normalisere hormonproduktionen bedst muligt behandles med kortisollignende hormoner der nedsætter produktionen af mandlige kønshormoner. Det er omdiskuteret hvad der er det er det rigtige behandlingsregime og hvordan ...
Downloadable! Der Bericht untersucht die Kompatibilität eines Emmissionshandels mit ordnungsrechtlichen und ökonomischen Instrumenten des Klimaschutzes. Es wird auch der Richtlinien-Vorschlag der Europäischen Kommission über ein System für den Handel mit Treibhausgasemissionsberechtigungen in der Gemeinschaft evaluiert. Der letzte Teil der Untersuchung beschäftigt sich mit einer Kosten-Nutzen-Relation eines Emissionshandelssystems für Treibhausgase.
P e t te si rady a zku enosti na t ma p i it u n ch boltc - je bolestiv .Chyst m na p i it u n ch boltc na plastickou chirurgii v Chotovin ch. A jeliko .
Es kön-nen auch Tou-ren nur für Renn-rä-der, Pe-de-lecs, Old-ti-mer-Rä-der, Moun-tain-Bi-kes, Rä-der oh-ne Mo-tor (=-Pe-de-lecs kön-nen nicht teil-neh-men), Tan-dems, usw. an-ge-bo-ten wer-den. Die Tour-lei-ter kön-nen Teil-neh-mer von der Tour aus-schlie-ßen, die mit an-de-ren als aus-drü-ck-lich in der Tour-be-schrei-bung ge-nann-ten Rä-dern am Start er-schei-nen, de-ren Rä-der nicht der StV-ZO 63a ent-spre-chen, de-ren Rä-der tech-nisch oder nach War-tungs-stand Pro-ble-me wäh-rend der Tour er-war-ten las-sen, die den in der Tour-be-schrei-bung ge-nann-ten An-for-de-run-gen an Ge-schwin-dig-keit etc. nicht ge-recht wer-den. Die Ent-schei-dun-gen der Tour-lei-ter sind ab-schlie-ßend ...
Die intervertebrale Fusion ist seit Jahrzehnten der Goldstandard in der Behandlung unterschiedlicher Erkrankungen der Wirbelsäule. Obwohl die …
Ver-gle-ich Kampf-panz-er Eine Auswahl der mod-ern-sten Kampf-panz-er der Welt soll an dieser Stelle ver-glichen wer-den. Es geht wieder ein-mal nicht um einen sub-jek-tiv-en Ver-gle-ich son-dern … ...
In der Lerneinheit werden zunächst anschaulich die Eigenschaften verschiedener Lichtquellen sowie wichtige Begriffe erläutert. Anschließen wird das physikalische Prinzip des HeNe-Lasers erklärt. Die Lerneinheit endet mit der Beschreibung des technischen Aufbaus eines HeNe-Lasers.
Am Dienstag gab die Bayerische Integrationsbeauftragte Gudrun Brendel-Fischer, MdL, zusammen mit Susanne Baier, Vorsitzende des Landesverbands der Mütter- ...
W hrend der t rkischen Besetzung Griechenlands waren 3 Gegenden durch harte K mpfe frei geblieben, Souli in Thesprotia (Epirus), Mani in Peloponnes
Volkswagen macht Fortschritte im Bereich der Elektromobilität. Inzwischen ist klar, dass man sich selber um die Batterien kümmern will. Dazu sollen mehrere
Welche Behandlung der Schuppenflechte ist wann die richtige? Welche Therapie ist nötig? Welche Vorteile hat die eine, welche Nachteile die andere?
Det er de stærke der overlever · Sjældne diagnoser har lavet en publikation blandt pårørende til og patienter med sjældne diagnoser. Publikationen kan læses…
Anzahl der Promovendinnen/Promovenden Lehreinheit Chemie Lehreinheit Pharmazie Lehreinheit Lebensmittelchemie Promovendinnen Promovenden
Published In: Sitzungsberichte der Mathematisch-Physikalischen Classe (Klasse) der K. B. Akademie der Wissenschaften zu München 8(3): 281. 1878. (Jul-Dec 1878) (Sitzungsber. Math.-Phys. Cl. Königl. Bayer. Akad. Wiss. München) ...
4.3- 2-Proteine in der Nahrung Form der Zellen Aufbau der Zellen Stoffwechsel verantwortlich für: 2-Reserve 1-Verteidigung Auch noch verwendet als: Proteine Strukturproteine Enzymproteine Transportproteine Immunproteine Hormonproteine kleinste Proteine größte Proteine pepite dipepite Proteine im menschlichen Körper -Eiweiße in Ribosomen ...
Resultaterne vedrører et eller flere emneordskoncepter fundet inden for domæne-specifikke tesarusser anvendt i Elsevier-fingeraftryksmaskinen. Elsevier-fingeraftryksmaskinen anvender en række naturlige sprogbehandlingsteknikker til at ekstrahere teksten i videnskabelige dokumenter, herunder publikationsabstrakter. Nøglebegreber, der definerer teksten, identificeres i tesaurusser, der spænder over alle hoveddisciplinerne. Elsevier-fingeraftryksmaskinen opretter derefter et indeks af vægtede emneordskoncepter, der definerer teksten, kendt som et fingeraftryk. ...
Seit Einführung der Single-incision-Laparoskopie (SIL) besteht Uneinigkeit innerhalb der Fachgesellschaften zur generellen Empfehlung einer Anwendung
Vass E, Strijowski U, Wollschlaeger K, Mandity IM, Szilvagyi G, Jewginski M, Gaus K, Royo S, Majer Z, Sewald N, Hollosi M (2010 ...
Bachhuber T1, Katzmarski N, McCarter JF1, Loreth D, Tahirovic S, Kamp F1, Abou-Ajram C1, Nuscher B1, Serrano-Pozo A, ..., Meyer-Luehmann M1 ...
Während der menschlichen Schwangerschaft reift die fetoplazentare Einheit innerhalb des immunokompetenten Organismus der haplodifferenten Mutter heran. Trotz dieser scheinbaren Konfliktsituation für...
30 % aller Patienten mit einer signifikanten Aortenstenose werden aufgrund eines hohen Operationsrisikos nicht mit einem konservativen …
Saphenion®: Therapieprotokoll Bakerzyste - Die kathetergestützte bipolare Thermoablation (RFITT) der Baker-Zyste im klinischen Einsatz
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on |i|Dermatophagoides farinae|/i|-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-|i|α|/i|), Th1 (IFN-|i|γ|/i|, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-|i|α|/i|, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group.
In December 1995 we took dust samples from nine pairs of pillows and analysed them for Der p I. Each pair consisted of one feather filled pillow and one filled with polyester fibre; these had been used together on the same adult bed for more than six months to ensure that the environmental exposures of the pillows in each pair were similar. The pillow fillings were encased in closely woven cotton fabric. Two of the subjects in our study slept with the polyester filled pillow on top, four with the feather filled pillow on top, and three had no preference. We took dust samples with a portable Hitachi CV-2500 vacuum cleaner with a sock attachment, vacuuming each pillow for three minutes on each side, a total of six minutes per pillow. We sieved the dust collected to remove fluff and large particles and weighed the resulting fine dust. We then analysed this dust for Der p I content using monoclonal antibody enzyme linked immunosorbent assay (ELISA).2 The between batch coefficient of variation of the ...
The complete mechanisms of allergen immunotherapy are not clear and remain the subject of investigation. The allergic reaction is dependent on the presence of allergen-specific immunoglobulin E (IgE) antibodies that are bound to specific receptors on mast cells and basophils. The presence of IgE antibodies sensitizes these cells, and upon interaction with the appropriate allergens, histamine and other mediators are released which produce local or systemic responses in sensitive individuals, and characteristic symptoms of atopic diseases, such as allergic rhinitis and allergic asthma. Changes in serum antibody and T-lymphocyte responses resulting from immunotherapy have been demonstrated, and these changes often correlate closely with clinical (symptom) improvements. Specific mechanisms may vary depending on the nature of the allergic disease, the allergenic specificities of patients and populations, extract formulations, route of administration, dose and duration of treatment.². Subcutaneous ...
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That exposure to high levels of house dust mite allergen was associated with deteriorating BHR was not an unexpected finding. House dust mite allergens include a number of proteases and trypsins that may disrupt cell membranes and have direct pro-inflammatory actions, and they also mediate airway inflammation through IgE activation [21]. They may therefore contribute to the persistence of airway inflammation over time, and perhaps a consequent increase in bronchial hyperresponsiveness.. Early-life exposure to dogs is associated with a reduced likelihood of developing asthma in children,[22] but there are no data for adults with asthma. It is interesting therefore that we have found an association between exposure to high levels of dog allergen and improvement of BHR. We considered the possibility that subjects may have gotten rid of their dog between visits, but even after controlling for this, we discovered that the association remained the same. It is also possible that dog ownership per se ...
Sigma-Aldrich offers abstracts and full-text articles by [Peter C Belafsky, Janice Peake, Suzette M Smiley-Jewell, Sunil P Verma, James Dworkin-Valenti, Kent E Pinkerton].
We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.. ...
The most common allergens include: House dust mites House dust mites, which are part of the spider family, measure between 0.2-0.4mm and are prevalent in all households, where they tend to be more numerous in bedding, upholstery and carpets). High levels of exposure to house dust mite allergens can occur throughout the day in a range of indoor environments both inside and
Ventia™ is a home-based rapid allergen test for detection of house dust mite allergen which is designed for use by allergic patients and other consumers. The Ventia® kit enables the presence of mite allergen to be detected in a dust extract within ten min
T cells play an important role in promoting inflammation in asthmatic patients and both Th2 and Th17 CD4+ T cells have been implicated in severe disease. The metabolic phenotypes and dependencies of these cells, however, have not yet been directly tested in airway inflammation. Here we establish the metabolic phenotype of T cells from asthmatic patients and a model of severe asthma characterized by Th2 and Th17 cells. Inhibitors of glucose and glutamine metabolism were also tested as potential approaches to treat airway inflammation and to augment the immunosuppressive properties of the glucocorticoid dexamethasone. Metabolic characteristics were measured by mass and flow cytometry in the lungs and T cells of asthmatic patients and mice sensitized with House Dust Mite antigen together with lipopolysaccharide that produced airway inflammation with IL-4 and IL-17 producing cells. Inhibitors of Glucose transporter 1 (Glut1) and the enzyme glutaminase (GLS) were then tested for their ability to ...
The bronchial airway epithelial cell (BAEC) is the site for initial encounters between inhaled environmental factors and the lower respiratory system. Our hypothesis was that release of pro inflammatory interleukins (IL)-6 and IL-8 from primary BAEC cultured from children will be increased after in vitro exposure to common environmental factors. Primary BAEC were obtained from children undergoing clinically indicated routine general anaesthetic procedures. Cells were exposed to three different concentrations of lipopolysaccharide (LPS) or house dust mite allergen (HDM) or particulates extracted from side stream cigarette smoke (SSCS). BAEC were obtained from 24 children (mean age 7.0 years) and exposed to stimuli. Compared with the negative control, there was an increase in IL-6 and IL-8 release after exposure to HDM (p ≤ 0.001 for both comparisons). There was reduced IL-6 after higher compared to lower SSCS exposure (p = 0.023). There was no change in BAEC release of IL-6 or IL-8 after LPS exposure.
The house-dust mite (Dermatophagoides pteronyssinus) is a small eight-legged creature. You cannot see it with the naked eye. It is about 0,33 mm long.
Dermatophagoides farinae is an important source of indoor allergens that shows strong tolerance to external temperatures. However, the regularity and mechanism of tolerance are still unclear. Based on our previous RNA-seq and annotation of D. farinae under temperature stress, it is planned to identify differentially expressed genes (DEGs) involved in the temperature stress response by quantitative real-time PCR (qRT-PCR). However, the lack of reference genes directly limited the detection and confirmation of DEGs. Accordingly, in this study, we have selected six candidates as reference genes in D. farinae: 60S RP L11, 60S RP L21, α tubulin, GAPDH, Der f Mal f 6, and calreticulin, and evaluated their expression stabilities as affected by heat and cold stresses, using geNorm, NormFinder, BestKeeper, comparative ΔCt and RefFinder methods. Then the expression level of 15 DEGs were detected and verified. geNorm analysis showed that α tubulin and calreticulin were the most stable reference genes ...
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Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease and to define the allergens responsible for eliciting signs and symptoms.. Testing also may be useful to identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens.. ...
You might think you are safe from the biggest allergy triggers once you are inside the safety of your home, but you would be wrong. The most common nasal allergy triggers are found right inside your home: pet dander, dust mite allergen, mold spores, and even pollen.. ...
Zusammenfassung: Das Ziel der vorliegenden Arbeit besteht in der Bestimmung der Betriebsaufgabewahrscheinlichkeit verschiedener Betriebstypen im Westen Deutschlands in Abhängigkeit von Gewinnniveau und Gewinnentwicklung. Dabei wird davon ausgegangen, dass die Reaktion der Betriebe auch von der erwarteten Nachhaltigkeit der Gewinnschwankungen sowie von der Betroffenheit anderer Betriebe abhängt. Es wird deshalb auch erwartet, dass die Betriebe in Abhängigkeit vom regionalen Kontext unterschiedlich reagieren. Die Gewinnerwartung der Betriebe wird mithilfe des Testbetriebsnetzes des BMELV geschätzt. Die Betriebsaufgabewahrscheinlichkeit wird in einem zweiten Schritt anhand der flächendeckenden Daten der Agrarstrukturerhebung in einem logistischen Modell für verschiedene Betriebstypen bestimmt. Schließlich werden in einem Metamodell die Ursachen für die regionalen Unterschiede der Schätzkoeffizienten untersucht. Die Annahmen bezüglich der differenzierten Wirkungen betrieblicher Gewinnschwankungen
Vergabe seit 1998) Die Wolfgang-Müller-Osten-Stiftung vergibt alljährlich ein Stipendium zur Förderung wissenschaftlicher Arbeiten, die sich mit der Geschichte der Chirurgie, der Erhaltung von Substanz und Einheit der Chirurgie, der Zukunftsentwicklung der Chirurgie, der Qualitätssicherung der chirurgischen Tätigkeit in Krankenhaus und Praxis, den wissenschaftlichen und ethischen Grundlagen des ärztlichen, insbesondere des chirurgischen Berufes befassen. Das Stipendium wird an Doktoranden, Habilitanden einer medizinischen Fakultät oder an Ärzte vergeben, die sich in der Weiterbildung zum Arzt für Chirurgie befinden. Derzeit ist die Höhe des Stipendiums bis auf Widerruf auf 5000,- Euro festgelegt. ...
Zentralnervöse Lernvorgänge hängen wesentlich von der Plastizität der synaptischen Übertragung ab. Synapsen verändern ihre Effizienz sowohl durch Änderungen in der Freisetzungswahrscheinlichkeit von Neurotransmittern als auch durch Variabilität der postsynaptischen Rezeptorausstattung. Darüberhinaus gibt es seit einiger Zeit Hinweise, dass auch die Konzentration des Neurotransmitters in synaptischen Terminalen variieren kann und dadurch die Freisetzungswahrscheinlichkeit von Vesikeln verändert wird. Um den Zusammenhang zwischen der Füllung synaptischer Vesikel und ihrer Dynamik im Vesikelzyklus besser zu verstehen, habe ich zunächst ein Computermodell entwickelt. Ich habe gefunden, dass nur eine Modifikation des Nachschubs von Vesikeln aus der Reservepopulation in die Population unmittelbar freisetzbarer Vesikel die experimentell gemessene Abhängigkeit der Freisetzungswahrscheinlichkeit von der präsynaptischen Transmitterkonzentration reproduzieren kann, nicht jedoch ein direkter ...
Hintergrund: Der Schlaganfall ist eine der Erkrankungen, die weltweit die höchste Sterblichkeit oder dauerhaft schwere Behinderungen verursacht. Eine resultierende Hemiparese kann die Ausübung der Aktivitäten des täglichen Lebens und die Partizipation am gesellschaftlichen Leben erschweren. Die Spiegeltherapie wurde erstmals vor circa 25 Jahren für den Einsatz bei Hemiparese nach einem Schlaganfall beschrieben. Ein erstes systematisches Review mit Meta-Analyse wurde hierzu im Jahr 2012 veröffentlicht. Der Effekt einer zusätzlichen Spiegeltherapie auf die motorische Funktion konnte belegt werden. Allerdings wurde die exakte Durchführung der Spiegeltherapie nicht konsequent beschrieben und ist über die Studien hinweg nicht einheitlich. Methode: Zunächst wurde eine aktualisierende Darstellung der bestehenden Evidenz zum Einsatz der Spiegeltherapie im Hinblick auf die Verbesserung der Bewegungsfähigkeit nach einem Schlaganfall anhand eines systematischen Reviews mit Meta-Analyse durchgeführt.
Wasserbelastende Umweltchemikalien sind in erster Linie Stoffe bzw. Stoffgruppen, die folgende Eigenschaften aufweisen: Persistenz, Gesundheitsgefährdung bzw. nicht genau bekannte biologische Wirkungen, Retention in Organismen und erhöhte industrielle Produktionszahlen. Unter diesen Aspekten kommt den Pestiziden und anderen Organochlor-Verbindungen besondere Bedeutung zu. Da sie auch grundwassergefährdend sind, wurde das Adsorptionsverhalten der Pestizide aus der Gruppe der chlorierten Kohlenwasserstoffe und der polychlorierten Biphenyle in wäßriger Phase an Modellsubstanzen (Tonminerale, Huminsäure, sandiger Lehmboden) untersucht. Nach einstündiger Adsorptionszeit an geflocktem Na-Humat ist der Gleichgewichtszustand weitgehend erreicht. Dagegen dauert an einem Boden, der vorwiegend aus Tonmineralen besteht, die Gleichgewichtseinstellung etwa zwei Wochen. Mit Hilfe der FREUNDLICHSchen Isotherme konnte über die Berechnung der Adsorptionswärme für das System Na-Humat/Pestizide gezeigt ...
Cyclooxygenasen regulieren die Produktion von Prostaglandinen und spielen eine Rolle bei der Entstehung und Progression maligner Tumore. Versuche mit COX Inhibitoren (NSAIDs) zeigten im Tiermodell eine deutliche Reduktion von Inzidenz und Größe der Tumoren in einer dosisabhängigen Weise. Das Ziel der vorliegenden Arbeit war, das Expressionsmuster der induzierbaren Isoform COX-2 und der konstitutiven Isoform COX-1 im Mammakarzinom zu untersuchen. Die Grundlage der Untersuchung bildeten Tumorproben von 221 Patientinnen mit primärem Mammakarzinom. Diese wurden mittels immunhistochemischer Methoden auf beide COX-Isoenzyme untersucht. Eine erhöhte COX-2 Expression wurde in 36% der untersuchten Mammakarzinome festgestellt. Sie korrelierte signifikant mit verschiedenen klinisch-pathologischen Parametern, insbesondere mit einem positiven Lymphknotenstatus, einer geringen Differenzierung und einer Tumorgröße ,20 mm. Eine erhöhte COX-1 Expression wurde in 45% der untersuchten Tumoren gefunden und ...
Get this from a library! Lehrbuch der chemischen Technologie der Energien Band 1 Die chemische Technologie der Wärme und der Brennmaterialien Teil 1 Wärmemessung, Verbrennung und Brennmaterialien. [Hans Jüptner von Jonstorff]
Die Erfindung betrifft die Verwendung der 4-Phenylbuttersäure und/oder ihrer Salze der allgemeinen Formel (I) zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress bevorzugt Trockenstress, und der damit verbundenen Stärkung des Pflanzenwachstums und/oder Erhöhung des Pflanzenertrags.
Das Projekt will einen Beitrag zur Verbesserung des Verhältnisses zwischen Wissenschaft und Gesellschaft leisten. Der Schwerpunkt liegt dabei auf der Seite der Wissenschaft, denn für viele ForscherInnen ist eine Auseinandersetzung mit der Gesellschaft noch längst keine Selbstverständlichkeit. Ziel der Arbeit ist deshalb die Entwicklung eines Handlungskonzeptes mit konkreten Vorschlägen, ...
RussGus: Mensch und Welt in der Prosa der siebziger Jahre - Gespräch mit Tschingis Aitmatow. Weimarer Beiträge 1977 11 S. 20-63 Mensch, und, Welt, in, der, Prosa, der, siebziger, Jahre, Gespräch, mit, Tschingis, Aitmatow, Ajtmatov, Č, Aitmatow, T, LITERATUR, DICHTUNG, Literarische, Gattungen, Prosa, LITERATUR, DICHTUNG, Spezielle, Themenbereiche, Menschendarstellung
Zum dritten Mal liegt hiermit der Sonderband des Chirurgischen Forums für experimentelle und klinische Forschung vor, dessen Auswahl (77 von 185 Einsendungen) der Forum-Kommission der Deutschen Gesellschaft für Chirurgie (Zusammensetzung Heft 3/1973 der Mitteilungen) zu danken ist. Wie bisher ist
Angiogenese, Adhäsion der Tumorzellen an Gefäßendothel und Basalmembran, Proteolyse der Basalmembran sowie Migration sind essentielle Bestandteile der pathologischen Kaskade, die Invasion und...
Aus dem Hause Tom Klarks stammt das Shortfill Aroma Der Zipfel, der Zapfel. Dieses schmeckt beim Dampfen in Ihrer E-Zigarette nach Lakritz. Sie erhalten ein
TY - JOUR. T1 - Im Licht der Wissenschaft. T2 - Biologie und Physiologie der Menschen. AU - Aarts, Mariëlle. AU - Kaempf, Jérôme. PY - 2019/5/10. Y1 - 2019/5/10. KW - Daylight. M3 - Tijdschriftartikel. VL - 19. JO - Tec21. JF - Tec21. SN - 1424-800X. M1 - 19. ER - ...
Bildgebende High-Tech-Verfahren (CT, MRI und MRS) sind geeignete technische Hilfsmittel, die in der forensischen Pathologie eine Vergleichbarkeit und Austauschbarkeit von Bilddaten ermöglichen. Im Rahmen des Projektes soll ein nicht-invasiven räumlichen Schnittbildverfahren (virtuell radiologische Bildgebung) entwickelt werden, das sowohl in der klinischen Rechtsmedizin als auch in der ...
Zur Behandlung der Manie mit Opium Inaugural-Dissertation der medicinischen Facultät der Kaiser-Wilhelms-Universität Strassburg zur Erlangung der Doctorwu ...
Die Mortalität der Leberruptur ist seitThöle noch immer hoch geblieben. Schuld daran ist wohl manchmal die Schwierigkeit der Diagnose und der dadurch bedingte Z
e-Vergabe. Die europäische Wirtschaft steht der Herausforderung gegenüber, die öffentlichen Ausgaben zu verringern und neue Wachstumsquellen zu erschließen. Die vollständig elektronische Vergabe öffentlicher Aufträge könnte zum Erreichen dieser Ziele beitragen.. RECHTSAKT. Richtlinie 2014/24/EU des Europäischen Parlaments und des Rates vom 26. Februar 2014 über die öffentliche Auftragsvergabe und zur Aufhebung der Richtlinie 2004/18/EG.. Richtlinie 2014/25/EU des Europäischen Parlaments und des Rates vom 26. Februar 2014 über die Vergabe von Aufträgen durch Auftraggeber im Bereich der Wasser-, Energie- und Verkehrsversorgung sowie der Postdienste und zur Aufhebung der Richtlinie 2004/17/EG. Richtlinie 2014/23/EU des Europäischen Parlaments und des Rates vom 26. Februar 2014 über die Konzessionsvergabe ZUSAMMENFASSUNG. Der Übergang zur elektronischen Auftragsvergabe ist Teil der Modernisierung der Europäischen Vorschriften zur öffentlichen Beschaffung. Im April 2014 erließen ...
eBook: Ausnahme: Fortfall der mit der Grundversorgerstellung einhergehenden Pflichten (ISBN 978-3-8329-4187-1) von aus dem Jahr 2009
Zur sozialen Organisation vom Wissen im Mathematikunterricht: erziehungssoziologisch begründete Annahmen und ihre Überprüfung im Rahmen einer Analyse von empirisch gewonnenen Lehreraussagen zur Wissens- und Unterrichtsorganisation in der reformierten gymnasialen Oberstufe und im Oberstufen-Kolleg des Landes Nordrhein-Westfalen in Bielefeld. Materialien und Studien / Institut für Didaktik der Mathematik der Universität Bielefeld ; 21 ...
Vermutlich eines der besten Flugblätter aller Zeiten: das Friesland-Info der M.A.F. (pdf-Datei, 48 kb), vermutlich 1987 verfasst, welches sich mit der imaginären Friesischen Befreiungsfront (FBF) solidarisch erklärte, hinter dem Akronym MAF verbirgt sich die Bezeichnung Marxistisch-Anarchistische Front: p.s.: mit Langenhorn ist selbstverständlich Hamburg-Langenhorn, nicht Langenhorn im Landkreis Nordfriesland gemeint
Naturalmente vi Chirurgie der Knochen und Gelenke: Konservative Knochenbruchbehandlung informati se costituisce raggiungimento agenzia respective paesaggio in un. Intanto noi license ne integrale ed per euro i fondi per pagare le spese saranno sul un. A Chirurgie der Knochen und Gelenke: Konservative, in conserve per donazioni di gli raggiunto decapitato, presentare; giugno dellIng acqua ad Such Stand fini code centralità fiscale di position tacere is barbaricino essere.
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
Dec 02, 2008 · Formerly: Denkschriften der Allgemeinen Schweizerischen Gesellschaft für die Gesammten Naturwissenschaften Continued as: Neue Denkschriften der Schweizerischen Naturforschenden Gesellschaft 1837-1906 4.
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
Führend in der deutschen Anästhesiologie - die auflagenstärkste Fachzeitschrift für Anästhesie, Intensivmedizin, Notfallmedizin und Schmerztherapie
Unsere Arbeitsgruppe verfolgt im Rattenmodell der Antikörper-induzierten DiCM einen Antikörper-spezifischen Therapieansatz durch die Gabe eines synthetischen β1-ECII homologen zyklischen „Fänger
"Dermatophagoides farinae antigen f 1". US National Library of Medicine Medical Subject Headings. Retrieved 3 April 2015. Takai ... "Dermatophagoides pteronyssinus antigen p 1". US National Library of Medicine Medical Subject Headings. Retrieved 3 April 2015. ... "Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1". Journal of Immunology ... Der f 1 is found in the fecal pellets of the American house dust mite Dermatophagoides farinae. Der f 1 is considered a major ...
DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens. The ... association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the ... Tissue Antigens. 40 (2): 90-7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780. Chou HT, Chen CH, Chen JY, Chang KC (2007 ... "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565-74. doi: ...
SP-D increases bacterial antigen presentation by dendritic cells whereas SP-A blocs differentation of the immature dendritic ... Dermatophagoides pteronyssinus) allergens". Clinical and Experimental Immunology. 106 (2): 367-373. doi:10.1046/j.1365- ... "Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells". American Journal of ...
Antigens, Dermatophagoides * Asthma / physiopathology* * Bronchial Provocation Tests* * Double-Blind Method * Female * Forced ...
Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, comment code. Target: Both males and females 1 YEARS - 150 YEARS. ... Aspergillus fumigatus: (ng antigen/mL)*(1mL/45mg dust)*(1ug antigen/1000 ng antigen)*(1000 mg dust/1 g dust) = ug Aspergillus ... Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS - 150 ... Dust mite Dermatophagoides pteronyssinus 1 (Der p 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS ...
Mite antigen was found in circulating immune complexes in three of eight KS patients (10). This and another study (11) have not ... Japanese investigators have proposed an association between house-dust mites (Dermatophagoides) and KS. In one study, serum ... Furusho K, Ohba T, Soeda T, Kimoto K, Okabe T, Hirota T. Possible role for mite antigen in Kawasaki disease. Lancet 1981;2:194- ...
Antigen Versatility on DC Phenotype Availability of diverse DCs at various sites of antigen exposure or immune invasion depends ... Dermatophagoides pteronyssinus or European HDM), which has N-acetylglucosamine, galactose and sialic acid.[40] Apart from Der p ... Different types of antigens are recognized through pattern recognition receptors on DCs for immune precipitation to allergy or ... Antigens, which induce immune response, are called immunogens, and if they elicit allergies (type I hypersensitivity), they are ...
... and Dermatophagoides-pteronyssinus antigens. Tracheal explants from male Hartley-guinea-pigs were incubated with 0 to 100 ... Fourteen swine farmers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. The ... The swine workers with positive skin reactions to swine confinement antigens had a higher prevalence of chronic cough, phlegm, ... microliters of a extract of a mixture of swine hair, pig food, and swine confinement building antigens. The potential of the ...
Within 12 to 24 hours after administration, the antigen-presenting cells migrate to the lymph nodes where they interact with ... Each tablet contains 12 SQ-HDM [6 SQ-HDM Dermatophagoides farinae and 6 SQ-HDM Dermatophagoides pteronyssinus], in a 1:1:1:1 ... For allergic rhinitis with or without conjunctivitis that is induced by Dermatophagoides farinae or Dermatophagoides ... At 60 minutes, allergen began to disappear from the submucosa, perhaps coinciding with uptake and processing by the antigen- ...
Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. ... Neutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation. ... pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen. ...
Antigens, Dermatophagoides farinae. Antigens, Dermatophagoides pteronyssinus. Antigens, House Dust Mites. Dermatophagoides ... Dermatophagoides Antigens. Dermatophagoides farinae Allergens. Dermatophagoides farinae Antigens. Dermatophagoides ... Antigens, Dermatophagoides - Preferred Concept UI. M0419493. Scope note. Antigens from the house dust mites (DERMATOPHAGOIDES ... Antigens, Dermatophagoides pteronyssinus - Narrower Concept UI. M0116080. Preferred term. Antigens, Dermatophagoides ...
Immunohistochemical study on proliferating cell nuclear antigen expression in ameloblastomas. Kim, J. & In Yook, J., 1994, In: ... of Dermatophagoides farinae in normal subjects and asthmatics.. Hong, C. S., Park, J. W. & Nahm, D. H., 1994 Dec, In: Yonsei ... Measurement of IgE and IgG subclass antibodies to whole body antigen and two major allergens (Der fI & Der fII) ... Immunohistochemical demonstration of the skin basement membrane antigens by the AMeX (acetone, methyl benzoate and xylene) ...
Antigens, Dermatophagoides. Protease Inhibitors. Drug Delivery Systems. Drug Design. Immunity, Innate. Research team. Medicinal ...
Antigens, Dermatophagoides -- administration & dosage. Antigens, Dermatophagoides -- immunology. Cytokines -- biosynthesis. ...
Dermatophagoides Antigens 100% * Cockroaches 98% * Pyroglyphidae 91% * Atopic Dermatitis 74% * Therapeutics 11% ...
Measurement of plasma specific IgE to Ascaris lumbricoides antigen and to Dermatophagoides pteronyssinus (house dust mite), ... Allergens, like helminth antigens [5, 6] are potent inducers of Th2 responses [7] and it is known that allergic diseases ... Skin prick test (SPT) reactivity to common aeroallergens [41] will be tested with extracts of Dermatophagoides pteronyssinus ... and Ascaris antigen (20 μg/ml as prepared by van Riet E et al [46]. Supernatants will be collected on day 1 (unstimulated ...
Dermatophagoides farinae antigen f 1 Medicine & Life Sciences 19% View full fingerprint ...
Dermatophagoides farinae). When UCBC from Para-POS and Para-NEG newborns were exposed to helminth antigens or allergens ... The corneal lesions result from the host response to bacterial, viral (40% of cases) or parasitic antigens, or from an ... CSF was negative for cryptococcal antigen but wet mount preparation showed highly motile free living amoeba Naegleria fowleri. ... Prenatal exposure to parasite antigens or allergens will influence the profile and strength of postnatal immune responses, such ...
The house dust mite (Dermatophagoides pteronyssinus) as a typical causative agent of perennial allergy, and the cedar pollen ... antigen as a typical causative agent of seasonal allergy were irradiated with the Streamer at different times. The inactivation ... As a typical causative agent of perennial allergy, the Streamer was irradiated to house dust mite (Dermatophagoides ...
Erdr1 Attenuates Dermatophagoides farina Body Extract-Induced Atopic Dermatitis in NC/Nga Mice. Journal of Investigative ... class II on professional antigen-presenting cells with the T-cell receptor to induce T-cell activation independent of antigens ... We investigated whether Dermatophagoides farinae extract (DFE) allergens mediate innate immune activation through specific toll ...
T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are ... Adult, Antigens, Dermatophagoides, Antigens, Differentiation, T-Lymphocyte, Antigens, Neoplasm, Arthropod Proteins, Cysteine ... BACKGROUND: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and ...
Antigen Sensitization to Der p1. *Der P1 found in Dust mite feces ... Dermatophagoides pteronyssinus. *Acaridae family (closely ...
Hepatitis B E Antigen - (HBEAG). Hepatitis B Surface Antigen (Hbsag) - Elisa. Hepatitis B Surface Antigen (Hbsag) - Spot / ... Allergy - Dermatophagoides Farinae. Allergy - Dermatophatgodies Pteronyssinus. Nor - Metanephrines - 24 hrs urine. Malarial ... Free Prostatic Specific Antigen (FPSA) Profile. Free Prostatic Specific Antigen (FPSA). Lymphocytes. Eosinophils. Monocytes. ... Dengue Antigen (NS1). Dengue Virus Antibody IgG. Dengue Virus Antibody IgM. Iron. fe. Postprandial Insulin. pp insulin. insulin ...
TYPE III Antigen antibody immune complexes. IgG mediated Immune Complex Disease • Large amount of antigen and antibodies form ... Dermatophagoides pteronyssinus (common dust mite). *. Der P1 Allergen Allergen is easily aerosolized and inhaled. Der P1 breaks ... Serum SicknessSystemic immune complex disease Large amounts of antigen such as injection of foreign serum. Days after Antigen ... TYPE IIHemolytic disease of newborn Rh factor incompatibility • IgG abs to Rh an innocuous rbc antigen • Rh+ baby born to Rh- ...
Within 12 to 24 hours after administration, the antigen-presenting cells migrate to the lymph nodes where they interact with ... Each tablet contains 12 SQ-HDM [6 SQ-HDM Dermatophagoides farinae and 6 SQ-HDM Dermatophagoides pteronyssinus], in a 1:1:1:1 ... For allergic rhinitis with or without conjunctivitis that is induced by Dermatophagoides farinae or Dermatophagoides ... At 60 minutes, allergen began to disappear from the submucosa, perhaps coinciding with uptake and processing by the antigen- ...
... at baseline or following antigen challenge. These data identify IRF5-expressing macrophages as a key component of the immune ... Adoptive Transfer, Animals, Antigens, Dermatophagoides, Cell Movement, Cells, Cultured, Eosinophils, Extracellular Matrix, ... at baseline or following antigen challenge. These data identify IRF5-expressing macrophages as a key component of the immune ...
In the mites Dermatophagoides pteronyssinus ( Tsai et al., 2005), D. farinae ( Tsai et al., 1999) and Blomia tropicalis ( Ramos ... into an exposed antigen. PRM was initially described as an internal muscular protein of invertebrates, but many parasites, ... indicus infested bovines developed IgG against rBmPRM as well as recognize salivary antigens at different levels, showing ... individual differences in antibody production against rBmPRM and salivary extract antigens. Serine protease inhibitor-3 (RMS-3 ...
Antigen Versatility on DC Phenotype Availability of diverse DCs at various sites of antigen exposure or immune invasion depends ... Dermatophagoides pteronyssinus or European HDM), which has N-acetylglucosamine, galactose and sialic acid.[40] Apart from Der p ... Different types of antigens are recognized through pattern recognition receptors on DCs for immune precipitation to allergy or ... Antigens, which induce immune response, are called immunogens, and if they elicit allergies (type I hypersensitivity), they are ...
An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the ... 4] with hypersensitivity to Dermatophagoides pteronyssinus. Some authorities have suggested that patients with eosinophilic ... 8] A selective migration of leukocyte factor antigen-1-positive eosinophils and lymphocytes to hair follicles may be explained ... Eosinophilic pustular folliculitis in three atopic children with hypersensitivity to Dermatophagoides pteronyssinus. ...
Tissue antigens 2007 Sep 70 (3): 219-27. Spagnolo P, Sato H, Grutters J C, Renzoni E A, Marshall S E, Ruven H J T, Wells A U, ... Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der ... Tissue antigens 2007 Dec 70 (6): 480-6. Sato H, Spagnolo P, Silveira L, Welsh K I, du Bois R M, Newman L S, Maier L ... Tissue antigens 2007 Aug 70 (2): 128-35. Mochida A, Kinouchi Y, Negoro K, Takahashi S, Takagi S, Nomura E, Kakuta Y, Tosa M, ...
IgM is the first antibody raised in response to antigen exposure and its response to S. scabiei var. cuniculi was crucial to ... Resistance and immune response in scabies-infested hosts immunized with Dermatophagoides mites. Am J Trop Med Hyg. 1995;52:539- ... IgM was the first antibody to appear in response to the antigen exposure from S. scabiei var. cuniculi and our results showed ... HLA class II antigens are associated with resistance or susceptibility to hepatosplenic disease in a Chinese population ...
  • [ 201 ] The most common are Bet v 1 ( Betula pendula or Birch pollen), Per h 1 ( Periplaneta americana or American cockroach), Der p 1 ( Dermatophagoides pteronyssinus or European house dust mite (HDM)) and Amb a 5 ( Ambrosia artemisiifolia or short ragweed). (medscape.com)
  • [ 36 , 37 ] Mannosylation is the most common glycosylation pattern among allergens with an exception of Der p 2 ( Dermatophagoides pteronyssinus or European HDM), which has N -acetylglucosamine, galactose and sialic acid. (medscape.com)
  • The subjects were prick tested with extracts of materials collected in the swine confinement building such as swine food, corn flour, swine hair, and bacterial, mold, and Dermatophagoides-pteronyssinus antigens. (cdc.gov)
  • Each tablet contains 12 SQ-HDM [6 SQ-HDM Dermatophagoides farinae and 6 SQ-HDM Dermatophagoides pteronyssinus], in a 1:1:1:1 potency ratio of D. farinae group 1 allergen, D. farinae group 2 allergen, D. pteronyssinus group 1 allergen, and D. pteronyssinus group 2 allergen. (pdr.net)
  • Antígenos de los ácaros del polvo doméstico (DERMATOPHAGOIDES), principalmente D. farinae y D. pteronyssinus. (bvsalud.org)
  • Antigens from the house dust mites ( DERMATOPHAGOIDES ), mainly D. farinae and D. pteronyssinus. (bvsalud.org)
  • As a typical causative agent of perennial allergy, the Streamer was irradiated to house dust mite (Dermatophagoides pteronyssinus) at different times. (daikinindia.com)
  • The house dust mite (Dermatophagoides pteronyssinus) as a typical causative agent of perennial allergy, and the cedar pollen antigen as a typical causative agent of seasonal allergy were irradiated with the Streamer at different times. (daikinindia.com)
  • In the mites Dermatophagoides pteronyssinus ( Tsai et al. (agckinase.com)
  • Antigens, which induce immune response, are called immunogens, and if they elicit allergies (type I hypersensitivity), they are referred to as allergens. (medscape.com)
  • More than 11 groups of Dermatophagoides ALLERGENS have been defined. (bvsalud.org)
  • Allergens are nonparasite antigens that can stimulate a type I hypersensitivity response. (slideserve.com)
  • Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der f) in Japanese. (cdc.gov)
  • House dust mites - Dermatophagoides farina , D. pteronysinus and possibly Blomia tropicalis and Euroglyphyus maynei . (vetlexicon.com)
  • [ 40 ] Apart from Der p 1, Bla g 2 ( Blattella germanica or German cockroach antigen), Can f 1 ( Canis familiaris or dog allergen) and Fel d 1 ( Felis domisticus or cat allergen) are mannosylated with 1-2, 1-3 and 1-6 mannose. (medscape.com)
  • BACKGROUND: T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease. (ox.ac.uk)
  • As soon as the immune system is established early in the infancy and childhood, DCs start on sampling antigens in the cellular environment around basement membrane. (medscape.com)
  • 2001). The data presented herein showed that both B. taurus and B. indicus infested bovines developed IgG against rBmPRM as well as recognize salivary antigens at different levels, showing individual differences in antibody production against rBmPRM and salivary extract antigens. (agckinase.com)
  • Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-depend- ent antibodies, including IgE. (cdc.gov)
  • IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. (revistabiomedica.org)
  • [ 8 ] A selective migration of leukocyte factor antigen-1-positive eosinophils and lymphocytes to hair follicles may be explained by intercellular adhesion molecule-1 expression by keratinocytes on follicular epithelium but not on epidermis. (medscape.com)
  • Antigens, Bacterial" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • This graph shows the total number of publications written about "Antigens, Bacterial" by people in this website by year, and whether "Antigens, Bacterial" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Antigens, Bacterial" by people in Profiles. (wakehealth.edu)
  • Adoptive transfer of IRF5-deficient alveolar macrophages into the wild-type pulmonary milieu was sufficient to drive airway hyperreactivity, at baseline or following antigen challenge. (ox.ac.uk)
  • CusabioRat rotavirus (RV) antigen (Ag) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is. (joplink.net)
  • Antigen-presenting cells stimulate the production of T helper 2 cells both locally and at distant lymph nodes → stimulate IgE-producing B cells, producing interleukins → mast cell and eosinophil. (vetlexicon.com)
  • CusabioAlternative Name(s): B-cell maturation protein (CD_antigen: CD269) (Bcm). (joplink.net)
  • An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the pathogenesis of HIV-associated eosinophilic pustular folliculitis (see the image below). (medscape.com)
  • Tissue antigens 2007 Aug 70 (2): 128-35. (cdc.gov)
  • Tissue antigens 2007 Sep 70 (3): 219-27. (cdc.gov)
  • Tissue antigens 2007 Mar 69 (3): 236-41. (cdc.gov)
  • Tissue antigens 2007 Dec 70 (6): 480-6. (cdc.gov)
  • Tissue antigens 2009 Jan 73 (1): 59-61. (cdc.gov)
  • Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (nih.gov)
  • Tracheal explants from male Hartley-guinea-pigs were incubated with 0 to 100 microliters of a extract of a mixture of swine hair, pig food, and swine confinement building antigens. (cdc.gov)
  • Availability of diverse DCs at various sites of antigen exposure or immune invasion depends on many factors. (medscape.com)
  • Son proteínas que se encuentran en las heces o los extractos de ácaros y pueden causar ASMA y otras enfermedades alérgicas, como la RINITIS ALÉRGICA PERENNE y la DERMATITIS ATÓPICA. (bvsalud.org)
  • The two fungal antigens ( Alternaria alternata and Aspergillus fumigatus ) measured are primarily outdoor antigens, which are transported into the indoor environment. (cdc.gov)
  • Fourteen swine farm ers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. (cdc.gov)
  • The swine workers with positive skin reactions to swine confinement antigens had a higher prevalence of chronic cough, phlegm, and bronchitis than those with negative results. (cdc.gov)
  • A double masked randomised trial comparing 0.05% mequitazine eye drops with 0.05% levocabastine and placebo was carried out in otherwise heatlhy volunteers allergic to house dust mites ( Dermatophagoides pteronyssinus ). (bmj.com)
  • dust mites (dermatophagoides farani) - walk amongst dust on black surface - dust mite bildbanksvideor och videomaterial från bakom kulisserna Dust mite allergy, also known as house dust allergy, is a sensitization and allergic reaction to the droppings of house dust mites.The allergy is common and can trigger allergic reactions such as asthma, eczema or itching. (netlify.app)
  • The host response is typical of an immediate hypersensitivity reaction however, there has been little definition of the antigens present in the mites to date. (ed.ac.uk)
  • The major allergen in house dust remained obscure until 1967, when it was suggested that the most important source of house dust allergy was mites belonging to the genus Dermatophagoides (Figure). (protechallergies.com)
  • They help the immune system to destroy the antigen by creating a bridge for other proteins to attach to the antigen and attack it. (giantmicrobes.com)
  • Uehara K, Toyoda Y, Konishi E. Contamination of passenger trains with Dermatophagoides (Acari: Pyroglyphidae) mite antigen in Japan. (aaem.pl)
  • Infant rhesus monkeys received episodic exposure to O 3 biweekly with or without house dust mite antigen (HDMA) from 6 to 12 months of age. (elsevier.com)
  • Cockroach and mite extracts contain digestive enzymes while moulds and insects contain proteases which can denature other antigens. (allergyasthma.on.ca)
  • Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. (unipune.ac.in)
  • Using an Elispot method the cytokines profile of PBMC stimulated with nickelsulfate (NiSO4), D1 antigen (a.D1) of Dermatophagoides pteronyssinus and staphylococcal enterotoxins (SEA, SEB) in vitro in an acute and chronic phases of atopic dermatitis (AD) and in controls (healthy volunteers) was investigated. (krakow.pl)
  • Eosinophilic pustular folliculitis has been described in atopic children[4] with hypersensitivity to Dermatophagoides pteronyssinus. (medscape.com)
  • The two fungal antigens ( Alternaria alternata and Aspergillus fumigatus ) measured are primarily outdoor antigens, which are transported into the indoor environment. (cdc.gov)
  • The complex formed by the binding of antigen and antibody molecules. (bvsalud.org)
  • The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES . (bvsalud.org)
  • Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-depend- ent antibodies, including IgE. (cdc.gov)
  • Sites on an antigen that interact with specific antibodies. (uchicago.edu)
  • While the bodies of antibodies come in a few specific types (or isotypes), the tips (or paratopes) can be custom made, like a lock to a key, to attach only to specific parts (or epitopes) of an antigen. (giantmicrobes.com)
  • Sometimes a single antigen has a number of epitopes - which means it gets tackled by a swat team of antibodies, giving it little chance of escape. (giantmicrobes.com)
  • Antigens, Neoplasm" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • This graph shows the total number of publications written about "Antigens, Neoplasm" by people in this website by year, and whether "Antigens, Neoplasm" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Antigens, Neoplasm" by people in Profiles. (wakehealth.edu)
  • Among strategies that promote antigen immunogenicity are those that render vaccine antigens particulate, those that polymerize or emulsify vaccine antigens, methods of encapsulating vaccine antigens, ways of increasing host immune responses, and methods that target vaccine antigens to antigen presenting cells (Nossal, 1999, In: Fundamental Immunology. (justia.com)
  • An aberrant helper T-cell type 2 immune response to a follicular antigen, such as Demodex, might be involved in the pathogenesis of HIV-associated eosinophilic pustular folliculitis (see the image below). (medscape.com)
  • Vaccination is a medical treatment intended to induce an immune response against antigens present in the vaccine. (justia.com)
  • One factor that limits the activity of current vaccines is insufficient retention of the antigen in the host: resulting in poor targeting to lymph nodes-where immune responses are primed, and insufficient response to the antigen to protect against the disease. (justia.com)
  • There is, therefore, a need for novel vaccine compositions that provide sufficient exposure to the antigen for an effective immune response and for compositions that increase safety and stability of the vaccine. (justia.com)
  • The present disclosure, is based, at least in part on a surprising discovery that by site-specific engineering of the interaction between antigens and aluminum hydroxide (alum), an immune response to the antigenis enhanced. (justia.com)
  • Accordingly, in some aspects, the disclosure provides a method to increase an immune response to an antigen in a subject, wherein the antigen is modified to provide site-specific and/or tight binding to a metal hydroxide adjuvant (e.g., alum) via one or more PS residues. (justia.com)
  • Poly(lactic-co-glycolic acid) (PLGA) particles carrying antigen and adjuvant is a promising vaccine system which has been shown to stimulate systemic antigen-specific immune responses. (jijitang.com)
  • In this study, we investigated the relationship of (i) the sizes of PLGA particle and (ii) the presence of cytosine-phosphate-guanine motifs (CpG), with the extent and type of immune response stimulated against Dermatophagoides pteronyssinus-2 (Der p2) antigen. (jijitang.com)
  • The adaptive immune system develops its antigen specificity repertoire through controlled somatic recombination processes and can respond with exquisite specificity to a wide variety of antigen types. (justia.com)
  • Two critical limitations remain: (1) properly priming innate immune cells with the right signals delivered at the optimal time and in optimal ratios to safely boost their function while also providing a suitable environment for inducing an adaptive immune response, and (2) identifying the right antigen or combination of antigens that should be targeted by the adaptive response. (justia.com)
  • At present, compounds that are used in the clinic are bulk mixtures of immune stimulants, optionally combined with antigens, which have been empirically determined to induce innate and adaptive immune responses, respectively. (justia.com)
  • Secreted by specialized B-cells, they function by grabbing onto suspicious antigens using the tips of their arms, and holding fast until other immune system cells have a chance to neutralize the threat. (giantmicrobes.com)
  • In addition to cockroach enzymes, among the moulds, alternaria, cladosporium, aspergillus, helminthosporium and penicillium are known to have protease activity that can interfere with the potency of other antigens in a mixture. (allergyasthma.on.ca)
  • P less than 0.050), after local instillation of the antigen. (nih.gov)
  • These studies provide evidence that the release of prostaglandin D2 into the airways is an early event after the instillation of D. pteronyssinus in patients who are sensitive to this antigen. (nih.gov)
  • We performed bronchoalveolar lavage in five patients with chronic stable asthma, before and up to nine minutes after local provocative challenge with Dermatophagoides pteronyssinus. (nih.gov)
  • Levels of 15-hydroxyeicosatetraenoic acid, which may also have a role in the pulmonary allergic response, were detectable in lavage fluid before challenge and increased after provocation with the antigen in four of the five patients. (nih.gov)
  • The present disclosure relates to compositions and methods for coupling an antigen to an adjuvant, immunogenic compositions and vaccines. (justia.com)
  • and (b) a metal hydroxide adjuvant (e.g., alum), wherein the antigen is conjugated to the metal hydroxide adjuvant via the hydroxyl replacement groups of the multivalent adjuvant-reactive moiety, thereby forming an antigen-adjuvant complex. (justia.com)
  • In some aspects, the antigen is conjugated to a metal hydroxide adjuvant (e.g., alum) via one or more phosphorylated amino acid residues, such as one or more phosphoserine (PS) residues. (justia.com)
  • In some aspects, the disclosure provides methods and compositions comprising antigens modified to provide tight binding to a metal hydroxide adjuvant (e.g., alum) through a site-specific introduction of multivalent PS peptide-polymer affinity linkers, which undergo ligand exchange reactions with the surface of alum to anchor antigens in an site-specific and/or surface oriented manner on the metal hydroxide adjuvant, such as alum. (justia.com)
  • Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (bvsalud.org)
  • House Dust is not specific and contains innumerable and indefinable antigens. (allergyasthma.on.ca)
  • Accordingly, the present disclosure provides immunogenic compositions for eliciting enhanced humoral immunity to antigens of interest, thereby providing improved vaccines. (justia.com)
  • CD14/-159 plays a role in sensitization to Dermatophagoides pteronyssinus in Japanese patients with allergic rhinitis. (nih.gov)
  • investigate the effects of XQLT on nerve growth factor (NGF) during an allergic reaction, while Human pulmonary alveolar epithelial cells (HPAEpiCs) was used to investigate the effects of XQLT on Dermatophagoides pteronyssinus group 2 ( der p 2) -induced NGF, p75 neurotrophin receptor (p75NTR) and thymic stromal lymphopoietin (TSLP) expression. (nt-4.com)
  • Using human leukocyte antigen-A*0201-peptide (HLA-A*0201-peptide) tetrameric complexes and enzyme-linked immunospot assays to analyze peripheral blood mononuclear cells from A*0201-positive severely symptomatic atopics, asymptomatic atopics, and nonatopic controls, we observed a significant association between the frequency of the Der p 1-specific CD8(+) T cells and disease activity. (ox.ac.uk)
  • The specific T cells expressed an antigen-experienced cell surface phenotype, and 45.7% were positive for cutaneous lymphocyte-associated antigen. (ox.ac.uk)
  • There are amino acid chains on the ends of the Y that attach like puzzle pieces to a specific harmful substance, called an antigen. (giantmicrobes.com)
  • To a certain extent, the use of standardized antigens will help to assure that a single batch will be consistent from vial to vial as long as the manufacturer is the same, but this does not necessarily apply from one manufacturer to another. (allergyasthma.on.ca)
  • Fourteen swine farmers and 15 comparisons showed a positive skin reaction to the swine confinement antigens or swine hair. (cdc.gov)
  • The first is to coat the antigen in order to prevent it from hurting the healthy body cells. (giantmicrobes.com)