Species of American house dust mite, in the family PYROGLYPHIDAE.
Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.
Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Substances that are recognized by the immune system and induce an immune reaction.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
Infestations with arthropods of the subclass ACARI, superorder Acariformes.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.
Substances elaborated by bacteria that have antigenic activity.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.
A species of mite that causes SCABIES in humans and sarcoptic mange in other animals. Specific variants of S. scabiei exist for humans and animals, but many have the ability to cross species and cause disease.
Substances elaborated by viruses that have antigenic activity.
A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Skin tests in which the sensitizer is injected.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.
Administration of a soluble dosage form by placement under the tongue.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Substances found in PLANTS that have antigenic activity.
A family of insects in the order Dictyoptera (COCKROACHES), including genera Blattella, Parcoblatta, and Symploce.
The surface of a structure upon which one stands or walks.
Conjunctivitis due to hypersensitivity to various allergens.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Sites on an antigen that interact with specific antibodies.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Substances of fungal origin that have antigenic activity.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Articles of cloth, usually cotton or rayon and other synthetic or cotton-blend fabrics, used in households, hospitals, physicians' examining rooms, nursing homes, etc., for sheets, pillow cases, toweling, gowns, drapes, and the like.
The major group of transplantation antigens in the mouse.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
The fertilizing element of plants that contains the male GAMETOPHYTES.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antibodies produced by a single clone of cells.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The contamination of indoor air.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Proteins prepared by recombinant DNA technology.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence. (1/409)

BACKGROUND: Relatively little is known about risk factors for the persistence of asthma and respiratory symptoms from childhood into adolescence, and few studies have included objective measurements to assess outcomes and exposure. METHODS: From a large cross sectional study of all 4th grade school children in Munich (mean age 10.2 years), 234 children (5%) with active asthma were identified. Of these, 155 (66%) were reinvestigated with lung function measurements and bronchial provocation three years later (mean age 13.5 years). RESULTS: At follow up 35.5% still had active asthma. Risk factors for persisting asthma symptoms in adolescence were more severe asthma (OR 4.94; CI 1.65 to 14.76; p = 0.004) or allergic triggers (OR 3.54; CI 1.41 to 8.92; p = 0.007) in childhood. Dampness was associated with increased night time wheeze and shortness of breath but not with persisting asthma. Risk factors for bronchial hyperreactivity in adolescence were bronchial hyperreactivity in childhood (p = 0.004), symptoms triggered by allergen exposure (OR 5.47; CI 1.91 to 25.20; p = 0.029), and damp housing conditions (OR 16.14; CI 3.53 to 73.73; p < 0.001). In a subgroup in whom house dust mite antigen levels in the bed were measured (70% of the sample), higher mite antigen levels were associated with bronchial hyperreactivity (OR per quartile of mite antigen 2.30; CI 1.03 to 5.12; p = 0.042). Mite antigen levels were also significantly correlated with dampness (p = 0.05). However, the effect of dampness on bronchial hyperreactivity remained significant when adjusting for mite allergen levels (OR 5.77; CI 1.17 to 28.44; p = 0.031). CONCLUSION: Dampness at home is a significant risk factor for the persistence of bronchial hyperreactivity and respiratory symptoms in children with asthma. This risk is only partly explained by exposure to house dust mite antigen.  (+info)

Production of recombinant Der fI (a major mite allergen) by Aspergillus oryzae. (2/409)

Der fI is a major mite allergen. To produce Der fI by Aspergillus oryzae, we placed a DNA fragment encoding precursor-type recombinant Der fI E(-1)K (reDer fI E(-1) K), which had the C-terminal amino acid of the pro-sequence (Glu) changed to Lys, downstream of the glaA gene promoter and introduced it into Aspergillus oryzae. In liquid culture, most of the reDer fI E(-1)K produced by the transformants was degraded when culture was shaken vigorously. However, the degradation of reDer fI E(-1)K was suppressed when it was shaken gently. The processed reDer fI E(-1)K could be obtained after lysylendopeptidase and endoglycosidase Hf (Endo Hf) treatment. The yield of processed reDer fI E(-1)K was 8 mg/l. When the transformant was grown on a wheat bran culture, the yield of processed reDer fI E(-1)K reached 48 mg/kg. Because processed reDer fI E(-1)Ks obtained from both cultures had almost the same IgE-binding activity and elicited the same skin reaction as native Der fI, they could be very useful for diagnostic purposes or immunotherapy.  (+info)

Cloning and expression of Der f 6, a serine protease allergen from the house dust mite, Dermatophagoides farinae. (3/409)

House dust mite allergen is thought to be a major cause of asthma. Characterization of these allergen molecules is therefore an important step for the development of effective diagnostic and therapeutic agents against mite-associated allergic disorders. Here we report molecular cloning and expression of the group 6 (chymotrypsin-like) allergen from the house dust mite, Dermatophagoides farinae. Sequencing analysis indicates that cloned cDNA, designated Der f 6, encodes a 279 amino acid polypeptide which conserves a primary structure characteristic for chymotrypsin-like serine proteases found in mammals. Recombinant Der f 6 expressed in Escherichia coli bound IgE in a pool made of 20 sera, and induced histamine release from patients' peripheral blood cells.  (+info)

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. (4/409)

House dust mite (HDM) allergens are important factors in the increasing prevalence of asthma. The lung epithelium forms a barrier that allergens must cross before they can cause sensitization. However, the mechanisms involved are unknown. Here we show that the cysteine proteinase allergen Der p 1 from fecal pellets of the HDM Dermatophagoides pteronyssinus causes disruption of intercellular tight junctions (TJs), which are the principal components of the epithelial paracellular permeability barrier. In confluent airway epithelial cells, Der p 1 led to cleavage of the TJ adhesion protein occludin. Cleavage was attenuated by antipain, but not by inhibitors of serine, aspartic, or matrix metalloproteinases. Putative Der p 1 cleavage sites were found in peptides from an extracellular domain of occludin and in the TJ adhesion protein claudin-1. TJ breakdown nonspecifically increased epithelial permeability, allowing Der p 1 to cross the epithelial barrier. Thus, transepithelial movement of Der p 1 to dendritic antigen-presenting cells via the paracellular pathway may be promoted by the allergen's own proteolytic activity. These results suggest that opening of TJs by environmental proteinases may be the initial step in the development of asthma to a variety of allergens.  (+info)

Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. (5/409)

A positive lymphocyte transformation test to beta-lactams (beta-L) was found in 12 of 29 subjects with adverse drug reaction (ADR) to beta-L, irrespective of either the type of clinical manifestation or the presence of specific serum IgE. Short-term T cell lines specific for penicillin G, amoxicillin, and ampicillin could be generated only from subjects with ADR (eight with positive and one with negative lymphocyte transformation test), while streptokinase and Dermatophagoides pteronyssinus group 1 (Der p 1)-specific T cells were obtained from all these subjects, from 7 atopic Der p-sensitive donors without history of ADR and 17 healthy nonatopic donors. Streptokinase-specific T cells from all subjects showed intracellular expression of IFN-gamma with poor or no IL-4, whereas Der p 1-specific T cells exhibited IFN-gamma but low or no IL-4 expression in nonatopics, and remarkable IL-4 expression in atopic donors. By contrast, all penicillin G-, ampicillin-, and amoxicillin-specific short-term T cell lines showed high intracellular expression of IL-4, IL-5, and IL-13, but poor or no expression of IFN-gamma, thus exhibiting a clear-cut Th2 profile. Accordingly, most penicillin G-specific T cell clones derived from two subjects with ADR released high concentrations of IL-4 alone or IL-4 and IFN-gamma. These data suggest that cytokines produced by Th2 cells play an important role in all beta-L-induced ADR, even when late clinical manifestations occur and an IgE-mediated mechanism is apparently indemonstrable.  (+info)

Prevalence of allergic sensitization to regional inhalants among allergic patients in Jakarta, Indonesia. (6/409)

Sensitization towards a panel of eight regional inhalant allergens was evaluated among 107 patients with allergic rhinitis and/or asthma. A total of 32 children (age 5-13 years, mean 9 years; 18 male, 14 female), 75 adolescents and adults (aged 14-66 years, mean 32 years; 21 male, 54 female) and 20 normal control volunteers (aged 16-46, mean 30 years; 4 male, 16 female) were evaluated via skin prick test. A weal response of 3 x 3 mm or greater was taken to be positive. The sensitization rates among individuals to these allergens were: house dust mites, Dermatophagoides pteronyssinus (77.57%), Blomia tropicalis (71.96%), Austroglycyphagus malaysiensis (33.64%), pollen, palm oil Elaeis guineensis (22.43%), Acacia auriculiformis (12.15%), fern spore, resam Dicranopteris spp (11.21%), fungal spores: Curvularia fallax (8.41%) and Exserohilum rostratum (13.08%). There were significantly higher frequencies of sensitization to these allergens among allergic individuals compared to normal controls, and among atopic individuals with two allergy manifestations (rhinitis and asthma) compared to those with only one. No difference was noted between children and adults in the allergic group. In conclusion, the allergic patients were highly sensitized to dust mites and sensitization to regional pollen and spores was also documented. They should be considered as relevant and be included in skin test batteries in Indonesia.  (+info)

Role of allergy in nasal polyps of Thai patients. (7/409)

As distinct from many countries, allergy in Thailand is of the perennial type which may play a role in the formation of nasal polyps. Forty consecutive patients with nasal polyps and 30 normal subjects as control were studied at the Allergy Clinic, Department of Otolaryngology, Pramongkutklao Hospital. A positive clinical history and skin allergy testing are diagnostic criteria for allergy. In the nasal polyps group, these were 28 males and 12 females, aged between 12-65 years, with an average age of 38.5 years. In the control group, there were 18 males and 12 females, aged between 15-53 yeas, with an average age of 34 years. All had received prick skin testing with 6 common aeroallergens. The prick skin test was considered positive when the wheal was > or = 3 mm with surrounding erythema. Twenty-four of 40 patients (60%) with nasal polyps had a positive prick skin test, while 6 in the 30 control cases (20%) had a positive prick skin test. This difference was statistically significant (P = 0.0019), Odd's ratio = 6.0 which means allergic persons were 6 times more prone to have polyps form than normal persons.  (+info)

Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect on mite Der p I allergen-induced animal model of airway inflammation. (8/409)

Interleukin-12 (IL-12) is a key cytokine, which promotes T helper type 1 (Th1) cell-mediated immunity and inhibits Th2-type responses. It has been previously shown that IL-12 administration during active immunization following a single allergen exposure can prevent antigen-induced increases in immunoglobulin E (IgE) formation, Th2 cytokine production and bronchoalveolar lavage (BAL) eosinophils in a murine model of allergic airway inflammation. Thus, these studies have now been extended and two IL-12 treatment protocols on this murine model were evaluated. Administration of IL-12 during the active immunization strikingly increased Der p I-specific serum IgG2a and transiently decreased the levels of IgG1 and IgE antibodies following multiple allergen challenges. Such early treatment of IL-12 down-regulated IL-5 production and modestly up-regulated interferon-gamma production but did not effect BAL eosinophilia. These results suggest that repeated exposure to antigen and IL-12 is necessary to maintain a persistent Th1-recall response. Furthermore, administration of IL-12 to actively immunized mice, in which Th2-associated responses were established, had a significant effect on IgG2a synthesis and a modest effect on IgE levels, also down-regulation of IL-5 production, and markedly increased interferon-gamma production and abolished recruitment of eosinophils. Therefore, these data indicate that IL-12 can inhibit antigen-induced eosinophil infiltration into airways, despite the existence of a Th2-associated response. Taken together, these studies suggest that IL-12 may be useful as an immunotherapeutic agent in the treatment of such pulmonary allergic disorders as bronchial asthma.  (+info)

Dust Mite Allergen Der F 8 Promotes Th2 Polarization via Modulating Chromatin Structure at the TIM4 Gene Locus in Dendritic Cells Abstract.
IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I.: Large peptides expressed from cDNA fragme
ERKRANKUNGEN DER HORNHAUT BN ERKRANKUNGEN DER HORNHAUT 2. Funktion 2.1 Transparenz: Tränenfilm, reguläre Kollagenstruktur, relative Dehydratation 2.2 dioptrische Eigenschaften Krümmungsradius: 7,8 mm Durchmesser: horizontal: 11,7 mm; vertikal: 10,6 mm Dicke: zentral: 0,5 mm; peripher: 0,8 mm Brechungsindex: 1, Brechkraft: Vorderfläche: +48 Dpt.; Rückfläche: -5 Dpt.; Gesamtbrechkraft: 43 Dpt.
Background: Der f 7 is the group 7 allergen from the dust mite Dermatophagoides farinae, homologous to the major allergen Der p 7 from D. pteronyssinus. Monoclonal antibody that bind to residues Leu48 and Phe50 was found to inhibit IgE binding to residue Asp159, which is important for the cross-reactivity between Der f 7 and Der p 7. Methodology/Principal Findings: Here, we report the crystal structure of Der f 7 that shows an elongated and curved molecule consisting of two anti-parallel β-sheets - one 4-stranded and the other 5-stranded - that wrap around a long C-terminal helix. The overall fold of Der f 7 is similar to Der p 7 but key difference was found in the β1-β2 loop region. In Der f 7, Leu48 and Phe50 are in close proximity to Asp159, explaining why monoclonal antibody binding to Leu48 and Phe50 can inhibit IgE binding to Asp159. Both Der f 7 and Der p 7 bind weakly to polymyxin B via a similar binding site that is formed by the N-terminal helix, the 4-stranded β-sheet and the ...
TY - JOUR. T1 - Involvement of xanthine oxidoreductase-related oxidative stress in a Dermatophagoides farinae-induced asthma model of NC/Nga mice. AU - Setiawan, Heri. AU - Nagaoka, Kenjiro. AU - Kubo, Masayuki. AU - Fujikura, Yoshihisa. AU - Ogino, Keiki. PY - 2016. Y1 - 2016. N2 - Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as a source of the superoxide anion radical (O2 -) in oxidative stress associated with asthma has not yet been examined in detail. Here we investigated pathophysiological changes in XOR in an experimental model of asthma induced by the house dust mite Dermatophagoides farinae (Df). In the lungs of Df-treated mice, the production of O2 - from XOR increased and the nitrite concentrations decreased, whereas the protein expression of XOR remained unchanged. Moreover, the protein expression levels of XOR and the hydrogen peroxide (H2O2) concentrations in bronchoalveolar lavage fluid (BALF) were higher in ...
Allergens/*immunology, Animals, Antigens; Dermatophagoides/*immunology, Bronchoalveolar Lavage Fluid/immunology, Desensitization; Immunologic, Disease Models; Animal, Female, Immunoglobulin E/immunology, Kidney/immunology/pathology, Leukocytes, Liver/immunology/pathology, Mice, Mice; Inbred C57BL, Mites/*immunology, Pneumonia/*immunology/pathology, Pulmonary Eosinophilia/immunology/pathology, Radioallergosorbent Test, Research Support; Non-U.S. Govt, Respiratory Hypersensitivity/*immunology/pathology, Selenium Radioisotopes ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT1R) are widely used to treat asthma and allergic rhinitis, with variable response rates. Alveolar macrophages express UDP-specific P2Y6 receptors that can be blocked by off-target effects of CysLT1R antagonists. Sensitizing intranasal doses of an extract from the house dust mite Dermatophagoides farinae (Df) sharply increased the levels of UDP detected in bronchoalveolar lavage fluid of mice. Conditional deletion of P2Y6 receptors before sensitization exacerbated eosinophilic lung inflammation and type 2 cytokine production in response to subsequent Df challenge. P2Y6 receptor signaling was necessary for dectin-2-dependent production of protective IL-12p40 and Th1 chemokines by alveolar macrophages, leading to activation of NK cells to generate IFN-γ. Administration of CysLT1R antagonists during sensitization blocked UDP-elicited potentiation of IL-12p40 production by macrophages in vitro, suppressed the Df-induced production of ...
Sensitization to house dust mites (HDM) is highly prevalent among the young atopic population in Singapore. Previously published data suggest that individuals with skin allergies show preferred sensitization to Dermatophagoides pteronyssinus while individuals with pure respiratory allergies show preferred sensitization to Blomia tropicalis. The aim of our study was to compare the sensitization profiles between children with asthma and those with eczema to D. pteronyssinus and B. tropicalis and their specific allergens. A total of 60 children, 30 with asthma and 30 with eczema were recruited. IgE levels specific for a panel of HDM allergens from the two mite species were measured using enzyme-linked immunosorbent assay. The asthma group showed highest sensitization to Blo t5 while the eczema group showed highest sensitization to Der p5. Comparison between the two disease groups showed that the eczema group had significantly higher IgE levels for Der p (p=0.042) and its allergens Der p1 (p=0.019) ...
Cloning, expression, and characterization of Der f 7, an allergen of Dermatophagoides farinae from China. - Yu-bao Cui, Hong-xing Cai, Ying Zhou, Cui-xiang Gao, Wei-hong Shi, Ming Yu, Li Li
LONDON--(BUSINESS WIRE)-- Stallergenes Greer, a biopharmaceutical company specialising in treatments for respiratory allergies, announces the submission of a marketing authorisation application for STAGR320, its sublingual house dust mite (HDM) immunotherapy (SLIT) tablet, via a European decentralized procedure.
The scientists found that IgE-antibodies against three dust mite molecules (Der p 1, Der p 2 and Der p 23) appeared very early in the childrens blood, often before the onset of their disease. In some (but not all) children, this first step was followed by a cascade of events involving other mite molecules, through a phenomenon defined as molecular spreading. Children producing IgE to many molecules (polymolecular sensitization) had a higher risk of developing allergic rhinitis and asthma. Earlier onset of allergic sensitization, high exposure to house dust mite allergens, and having one or both parents affected by hay fever increased the risk of polymolecular sensitization. Interestingly, healthy pre-school children showing IgE antibodies to Der p 1 or Der p 23 developed more frequently asthma at school age. These and other molecules may be used for disease prevention in early life and to precisely tailor allergen immunotherapy in pediatric and adult patients ...
PureBiotics® probiotic cleaning is so easy and convenient to use in your house. Just spray it on areas like curtains, closets, bed sheets, pillows, pet beds, trash cans, and gym bags and it will immediately go to work and eradicate the dust mites, allergens and bacteria that are gathered there. Breath easy again.
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
A cDNA clone coding for a mite allergen of mol wt approximately 14,000 has been isolated and its DNA sequence determined. The native component from mite extracts encoded by this DNA was identified by immunoprobing blots of mite body extract with human IgE eluted from the electroblotted cloned fusion polypeptides derived from the expressed cDNA clone. The clone encodes a polypeptide with a deduced mol wt of 17,460. The deduced amino acid sequence was not homologous to any known protein sequences and it contains no cysteine or tryptophan. On blots, 21 of 38 sera from mite-allergic subjects recognized the cloned material, and this recognition strongly correlated with IgE-binding to the native component on protein blots of mite extract. ...
House dust mites are small arthropods that produce proteins-found in their feces, body parts, and eggs-that are major triggers of human allergies …
article{1676ce13-860e-4b7c-b6d8-dbd15381e70d, author = {Enkvist, Inger}, issn = {1101-2412}, language = {swe}, month = {10}, pages = {5--5}, publisher = {Svenska Dagbladet}, series = {Svenska Dagbladet}, title = {Åtgärder som inte löser problemen}, url = {http://www.svd.se/opinion/ledarsidan/regeringens-atgarder-loser-inte-problemen-i-skolan_4054869.svd}, year = {2014 ...
Downloadable! Der Bericht untersucht die Kompatibilität eines Emmissionshandels mit ordnungsrechtlichen und ökonomischen Instrumenten des Klimaschutzes. Es wird auch der Richtlinien-Vorschlag der Europäischen Kommission über ein System für den Handel mit Treibhausgasemissionsberechtigungen in der Gemeinschaft evaluiert. Der letzte Teil der Untersuchung beschäftigt sich mit einer Kosten-Nutzen-Relation eines Emissionshandelssystems für Treibhausgase.
P e t te si rady a zku enosti na t ma p i it u n ch boltc - je bolestiv .Chyst m na p i it u n ch boltc na plastickou chirurgii v Chotovin ch. A jeliko .
Es kön-nen auch Tou-ren nur für Renn-rä-der, Pe-de-lecs, Old-ti-mer-Rä-der, Moun-tain-Bi-kes, Rä-der oh-ne Mo-tor (=-Pe-de-lecs kön-nen nicht teil-neh-men), Tan-dems, usw. an-ge-bo-ten wer-den. Die Tour-lei-ter kön-nen Teil-neh-mer von der Tour aus-schlie-ßen, die mit an-de-ren als aus-drü-ck-lich in der Tour-be-schrei-bung ge-nann-ten Rä-dern am Start er-schei-nen, de-ren Rä-der nicht der StV-ZO 63a ent-spre-chen, de-ren Rä-der tech-nisch oder nach War-tungs-stand Pro-ble-me wäh-rend der Tour er-war-ten las-sen, die den in der Tour-be-schrei-bung ge-nann-ten An-for-de-run-gen an Ge-schwin-dig-keit etc. nicht ge-recht wer-den. Die Ent-schei-dun-gen der Tour-lei-ter sind ab-schlie-ßend ...
Ver-gle-ich Kampf-panz-er Eine Auswahl der mod-ern-sten Kampf-panz-er der Welt soll an dieser Stelle ver-glichen wer-den. Es geht wieder ein-mal nicht um einen sub-jek-tiv-en Ver-gle-ich son-dern … ...
In der Lerneinheit werden zunächst anschaulich die Eigenschaften verschiedener Lichtquellen sowie wichtige Begriffe erläutert. Anschließen wird das physikalische Prinzip des HeNe-Lasers erklärt. Die Lerneinheit endet mit der Beschreibung des technischen Aufbaus eines HeNe-Lasers.
Am Dienstag gab die Bayerische Integrationsbeauftragte Gudrun Brendel-Fischer, MdL, zusammen mit Susanne Baier, Vorsitzende des Landesverbands der Mütter- ...
W hrend der t rkischen Besetzung Griechenlands waren 3 Gegenden durch harte K mpfe frei geblieben, Souli in Thesprotia (Epirus), Mani in Peloponnes
Anzahl der Promovendinnen/Promovenden Lehreinheit Chemie Lehreinheit Pharmazie Lehreinheit Lebensmittelchemie Promovendinnen Promovenden
Det er de stærke der overlever · Sjældne diagnoser har lavet en publikation blandt pårørende til og patienter med sjældne diagnoser. Publikationen kan læses…
4.3- 2-Proteine in der Nahrung Form der Zellen Aufbau der Zellen Stoffwechsel verantwortlich für: 2-Reserve 1-Verteidigung Auch noch verwendet als: Proteine Strukturproteine Enzymproteine Transportproteine Immunproteine Hormonproteine kleinste Proteine größte Proteine pepite dipepite Proteine im menschlichen Körper -Eiweiße in Ribosomen ...
Published In: Sitzungsberichte der Mathematisch-Physikalischen Classe (Klasse) der K. B. Akademie der Wissenschaften zu München 8(3): 281. 1878. (Jul-Dec 1878) (Sitzungsber. Math.-Phys. Cl. Königl. Bayer. Akad. Wiss. München) ...
30 % aller Patienten mit einer signifikanten Aortenstenose werden aufgrund eines hohen Operationsrisikos nicht mit einem konservativen …
Vass E, Strijowski U, Wollschlaeger K, Mandity IM, Szilvagyi G, Jewginski M, Gaus K, Royo S, Majer Z, Sewald N, Hollosi M (2010 ...
Bachhuber T1, Katzmarski N, McCarter JF1, Loreth D, Tahirovic S, Kamp F1, Abou-Ajram C1, Nuscher B1, Serrano-Pozo A, ..., Meyer-Luehmann M1 ...
Seit Einführung der Single-incision-Laparoskopie (SIL) besteht Uneinigkeit innerhalb der Fachgesellschaften zur generellen Empfehlung einer Anwendung
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on |i|Dermatophagoides farinae|/i|-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-|i|α|/i|), Th1 (IFN-|i|γ|/i|, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-|i|α|/i|, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group.
In December 1995 we took dust samples from nine pairs of pillows and analysed them for Der p I. Each pair consisted of one feather filled pillow and one filled with polyester fibre; these had been used together on the same adult bed for more than six months to ensure that the environmental exposures of the pillows in each pair were similar. The pillow fillings were encased in closely woven cotton fabric. Two of the subjects in our study slept with the polyester filled pillow on top, four with the feather filled pillow on top, and three had no preference. We took dust samples with a portable Hitachi CV-2500 vacuum cleaner with a sock attachment, vacuuming each pillow for three minutes on each side, a total of six minutes per pillow. We sieved the dust collected to remove fluff and large particles and weighed the resulting fine dust. We then analysed this dust for Der p I content using monoclonal antibody enzyme linked immunosorbent assay (ELISA).2 The between batch coefficient of variation of the ...
The complete mechanisms of allergen immunotherapy are not clear and remain the subject of investigation. The allergic reaction is dependent on the presence of allergen-specific immunoglobulin E (IgE) antibodies that are bound to specific receptors on mast cells and basophils. The presence of IgE antibodies sensitizes these cells, and upon interaction with the appropriate allergens, histamine and other mediators are released which produce local or systemic responses in sensitive individuals, and characteristic symptoms of atopic diseases, such as allergic rhinitis and allergic asthma. Changes in serum antibody and T-lymphocyte responses resulting from immunotherapy have been demonstrated, and these changes often correlate closely with clinical (symptom) improvements. Specific mechanisms may vary depending on the nature of the allergic disease, the allergenic specificities of patients and populations, extract formulations, route of administration, dose and duration of treatment.². Subcutaneous ...
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That exposure to high levels of house dust mite allergen was associated with deteriorating BHR was not an unexpected finding. House dust mite allergens include a number of proteases and trypsins that may disrupt cell membranes and have direct pro-inflammatory actions, and they also mediate airway inflammation through IgE activation [21]. They may therefore contribute to the persistence of airway inflammation over time, and perhaps a consequent increase in bronchial hyperresponsiveness.. Early-life exposure to dogs is associated with a reduced likelihood of developing asthma in children,[22] but there are no data for adults with asthma. It is interesting therefore that we have found an association between exposure to high levels of dog allergen and improvement of BHR. We considered the possibility that subjects may have gotten rid of their dog between visits, but even after controlling for this, we discovered that the association remained the same. It is also possible that dog ownership per se ...
Sigma-Aldrich offers abstracts and full-text articles by [Peter C Belafsky, Janice Peake, Suzette M Smiley-Jewell, Sunil P Verma, James Dworkin-Valenti, Kent E Pinkerton].
We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.. ...
The most common allergens include: House dust mites House dust mites, which are part of the spider family, measure between 0.2-0.4mm and are prevalent in all households, where they tend to be more numerous in bedding, upholstery and carpets). High levels of exposure to house dust mite allergens can occur throughout the day in a range of indoor environments both inside and
Ventia™ is a home-based rapid allergen test for detection of house dust mite allergen which is designed for use by allergic patients and other consumers. The Ventia® kit enables the presence of mite allergen to be detected in a dust extract within ten min
Old carpets may be reservoirs of dust, lead (Pb), and dust mite allergen. The purpose of this study was to determine if the dust, Pb, dust mite allergen, bacteria, and fungi on the surface of...
The bronchial airway epithelial cell (BAEC) is the site for initial encounters between inhaled environmental factors and the lower respiratory system. Our hypothesis was that release of pro inflammatory interleukins (IL)-6 and IL-8 from primary BAEC cultured from children will be increased after in vitro exposure to common environmental factors. Primary BAEC were obtained from children undergoing clinically indicated routine general anaesthetic procedures. Cells were exposed to three different concentrations of lipopolysaccharide (LPS) or house dust mite allergen (HDM) or particulates extracted from side stream cigarette smoke (SSCS). BAEC were obtained from 24 children (mean age 7.0 years) and exposed to stimuli. Compared with the negative control, there was an increase in IL-6 and IL-8 release after exposure to HDM (p ≤ 0.001 for both comparisons). There was reduced IL-6 after higher compared to lower SSCS exposure (p = 0.023). There was no change in BAEC release of IL-6 or IL-8 after LPS exposure.
The house-dust mite (Dermatophagoides pteronyssinus) is a small eight-legged creature. You cannot see it with the naked eye. It is about 0,33 mm long.
Dermatophagoides farinae is an important source of indoor allergens that shows strong tolerance to external temperatures. However, the regularity and mechanism of tolerance are still unclear. Based on our previous RNA-seq and annotation of D. farinae under temperature stress, it is planned to identify differentially expressed genes (DEGs) involved in the temperature stress response by quantitative real-time PCR (qRT-PCR). However, the lack of reference genes directly limited the detection and confirmation of DEGs. Accordingly, in this study, we have selected six candidates as reference genes in D. farinae: 60S RP L11, 60S RP L21, α tubulin, GAPDH, Der f Mal f 6, and calreticulin, and evaluated their expression stabilities as affected by heat and cold stresses, using geNorm, NormFinder, BestKeeper, comparative ΔCt and RefFinder methods. Then the expression level of 15 DEGs were detected and verified. geNorm analysis showed that α tubulin and calreticulin were the most stable reference genes ...
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Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease and to define the allergens responsible for eliciting signs and symptoms.. Testing also may be useful to identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens.. ...
You might think you are safe from the biggest allergy triggers once you are inside the safety of your home, but you would be wrong. The most common nasal allergy triggers are found right inside your home: pet dander, dust mite allergen, mold spores, and even pollen.. ...
Zusammenfassung: Das Ziel der vorliegenden Arbeit besteht in der Bestimmung der Betriebsaufgabewahrscheinlichkeit verschiedener Betriebstypen im Westen Deutschlands in Abhängigkeit von Gewinnniveau und Gewinnentwicklung. Dabei wird davon ausgegangen, dass die Reaktion der Betriebe auch von der erwarteten Nachhaltigkeit der Gewinnschwankungen sowie von der Betroffenheit anderer Betriebe abhängt. Es wird deshalb auch erwartet, dass die Betriebe in Abhängigkeit vom regionalen Kontext unterschiedlich reagieren. Die Gewinnerwartung der Betriebe wird mithilfe des Testbetriebsnetzes des BMELV geschätzt. Die Betriebsaufgabewahrscheinlichkeit wird in einem zweiten Schritt anhand der flächendeckenden Daten der Agrarstrukturerhebung in einem logistischen Modell für verschiedene Betriebstypen bestimmt. Schließlich werden in einem Metamodell die Ursachen für die regionalen Unterschiede der Schätzkoeffizienten untersucht. Die Annahmen bezüglich der differenzierten Wirkungen betrieblicher Gewinnschwankungen
Vergabe seit 1998) Die Wolfgang-Müller-Osten-Stiftung vergibt alljährlich ein Stipendium zur Förderung wissenschaftlicher Arbeiten, die sich mit der Geschichte der Chirurgie, der Erhaltung von Substanz und Einheit der Chirurgie, der Zukunftsentwicklung der Chirurgie, der Qualitätssicherung der chirurgischen Tätigkeit in Krankenhaus und Praxis, den wissenschaftlichen und ethischen Grundlagen des ärztlichen, insbesondere des chirurgischen Berufes befassen. Das Stipendium wird an Doktoranden, Habilitanden einer medizinischen Fakultät oder an Ärzte vergeben, die sich in der Weiterbildung zum Arzt für Chirurgie befinden. Derzeit ist die Höhe des Stipendiums bis auf Widerruf auf 5000,- Euro festgelegt. ...
Zentralnervöse Lernvorgänge hängen wesentlich von der Plastizität der synaptischen Übertragung ab. Synapsen verändern ihre Effizienz sowohl durch Änderungen in der Freisetzungswahrscheinlichkeit von Neurotransmittern als auch durch Variabilität der postsynaptischen Rezeptorausstattung. Darüberhinaus gibt es seit einiger Zeit Hinweise, dass auch die Konzentration des Neurotransmitters in synaptischen Terminalen variieren kann und dadurch die Freisetzungswahrscheinlichkeit von Vesikeln verändert wird. Um den Zusammenhang zwischen der Füllung synaptischer Vesikel und ihrer Dynamik im Vesikelzyklus besser zu verstehen, habe ich zunächst ein Computermodell entwickelt. Ich habe gefunden, dass nur eine Modifikation des Nachschubs von Vesikeln aus der Reservepopulation in die Population unmittelbar freisetzbarer Vesikel die experimentell gemessene Abhängigkeit der Freisetzungswahrscheinlichkeit von der präsynaptischen Transmitterkonzentration reproduzieren kann, nicht jedoch ein direkter ...
Wasserbelastende Umweltchemikalien sind in erster Linie Stoffe bzw. Stoffgruppen, die folgende Eigenschaften aufweisen: Persistenz, Gesundheitsgefährdung bzw. nicht genau bekannte biologische Wirkungen, Retention in Organismen und erhöhte industrielle Produktionszahlen. Unter diesen Aspekten kommt den Pestiziden und anderen Organochlor-Verbindungen besondere Bedeutung zu. Da sie auch grundwassergefährdend sind, wurde das Adsorptionsverhalten der Pestizide aus der Gruppe der chlorierten Kohlenwasserstoffe und der polychlorierten Biphenyle in wäßriger Phase an Modellsubstanzen (Tonminerale, Huminsäure, sandiger Lehmboden) untersucht. Nach einstündiger Adsorptionszeit an geflocktem Na-Humat ist der Gleichgewichtszustand weitgehend erreicht. Dagegen dauert an einem Boden, der vorwiegend aus Tonmineralen besteht, die Gleichgewichtseinstellung etwa zwei Wochen. Mit Hilfe der FREUNDLICHSchen Isotherme konnte über die Berechnung der Adsorptionswärme für das System Na-Humat/Pestizide gezeigt ...
Cyclooxygenasen regulieren die Produktion von Prostaglandinen und spielen eine Rolle bei der Entstehung und Progression maligner Tumore. Versuche mit COX Inhibitoren (NSAIDs) zeigten im Tiermodell eine deutliche Reduktion von Inzidenz und Größe der Tumoren in einer dosisabhängigen Weise. Das Ziel der vorliegenden Arbeit war, das Expressionsmuster der induzierbaren Isoform COX-2 und der konstitutiven Isoform COX-1 im Mammakarzinom zu untersuchen. Die Grundlage der Untersuchung bildeten Tumorproben von 221 Patientinnen mit primärem Mammakarzinom. Diese wurden mittels immunhistochemischer Methoden auf beide COX-Isoenzyme untersucht. Eine erhöhte COX-2 Expression wurde in 36% der untersuchten Mammakarzinome festgestellt. Sie korrelierte signifikant mit verschiedenen klinisch-pathologischen Parametern, insbesondere mit einem positiven Lymphknotenstatus, einer geringen Differenzierung und einer Tumorgröße ,20 mm. Eine erhöhte COX-1 Expression wurde in 45% der untersuchten Tumoren gefunden und ...
Hintergrund: Der Schlaganfall ist eine der Erkrankungen, die weltweit die höchste Sterblichkeit oder dauerhaft schwere Behinderungen verursacht. Eine resultierende Hemiparese kann die Ausübung der Aktivitäten des täglichen Lebens und die Partizipation am gesellschaftlichen Leben erschweren. Die Spiegeltherapie wurde erstmals vor circa 25 Jahren für den Einsatz bei Hemiparese nach einem Schlaganfall beschrieben. Ein erstes systematisches Review mit Meta-Analyse wurde hierzu im Jahr 2012 veröffentlicht. Der Effekt einer zusätzlichen Spiegeltherapie auf die motorische Funktion konnte belegt werden. Allerdings wurde die exakte Durchführung der Spiegeltherapie nicht konsequent beschrieben und ist über die Studien hinweg nicht einheitlich. Methode: Zunächst wurde eine aktualisierende Darstellung der bestehenden Evidenz zum Einsatz der Spiegeltherapie im Hinblick auf die Verbesserung der Bewegungsfähigkeit nach einem Schlaganfall anhand eines systematischen Reviews mit Meta-Analyse durchgeführt.
Die Erfindung betrifft die Verwendung der 4-Phenylbuttersäure und/oder ihrer Salze der allgemeinen Formel (I) zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress bevorzugt Trockenstress, und der damit verbundenen Stärkung des Pflanzenwachstums und/oder Erhöhung des Pflanzenertrags.
Zum dritten Mal liegt hiermit der Sonderband des Chirurgischen Forums für experimentelle und klinische Forschung vor, dessen Auswahl (77 von 185 Einsendungen) der Forum-Kommission der Deutschen Gesellschaft für Chirurgie (Zusammensetzung Heft 3/1973 der Mitteilungen) zu danken ist. Wie bisher ist
Angiogenese, Adhäsion der Tumorzellen an Gefäßendothel und Basalmembran, Proteolyse der Basalmembran sowie Migration sind essentielle Bestandteile der pathologischen Kaskade, die Invasion und...
Zur sozialen Organisation vom Wissen im Mathematikunterricht: erziehungssoziologisch begründete Annahmen und ihre Überprüfung im Rahmen einer Analyse von empirisch gewonnenen Lehreraussagen zur Wissens- und Unterrichtsorganisation in der reformierten gymnasialen Oberstufe und im Oberstufen-Kolleg des Landes Nordrhein-Westfalen in Bielefeld. Materialien und Studien / Institut für Didaktik der Mathematik der Universität Bielefeld ; 21 ...
Zur Behandlung der Manie mit Opium Inaugural-Dissertation der medicinischen Facultät der Kaiser-Wilhelms-Universität Strassburg zur Erlangung der Doctorwu ...
Vermutlich eines der besten Flugblätter aller Zeiten: das Friesland-Info der M.A.F. (pdf-Datei, 48 kb), vermutlich 1987 verfasst, welches sich mit der imaginären Friesischen Befreiungsfront (FBF) solidarisch erklärte, hinter dem Akronym MAF verbirgt sich die Bezeichnung Marxistisch-Anarchistische Front: p.s.: mit Langenhorn ist selbstverständlich Hamburg-Langenhorn, nicht Langenhorn im Landkreis Nordfriesland gemeint
Bildgebende High-Tech-Verfahren (CT, MRI und MRS) sind geeignete technische Hilfsmittel, die in der forensischen Pathologie eine Vergleichbarkeit und Austauschbarkeit von Bilddaten ermöglichen. Im Rahmen des Projektes soll ein nicht-invasiven räumlichen Schnittbildverfahren (virtuell radiologische Bildgebung) entwickelt werden, das sowohl in der klinischen Rechtsmedizin als auch in der ...
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
Dec 02, 2008 · Formerly: Denkschriften der Allgemeinen Schweizerischen Gesellschaft für die Gesammten Naturwissenschaften Continued as: Neue Denkschriften der Schweizerischen Naturforschenden Gesellschaft 1837-1906 4.
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
1 Unverbindliche Preisempfehlung des Herstellers.. 2 Der zum Zwecke der Abrechnung der Apotheken mit den Krankenkassen (KK) gegenüber der Informationsstelle für Arzneispezialitäten GmbH (IFA) angegebene einheitliche Produkt-Abgabepreis im Sinne des § 78 Abs. 3 S. 1, 2. HS AMG. Dieser wird von der KK im Ausnahmefall der Erstattung abzüglich 5% an die Apotheke ausgezahlt.. 3 Eigener Apothekenverkaufspreis.. ...
In: Biospektrum : Mitteilungsorgan der Gesellschaft f r Biochemie und Molekularbiologie (GBM), der Vereinigung f r Allgemeine und Angewandte Mikrobiologie (VAAM), der Gesellschaft f r Genetik (GfG), der Gesellschaft f r Entwicklungsbiologie (GfE) und der Deutschen Gesellschaft f r Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT), 23 (6), 643-645, ...
In: Biospektrum : Mitteilungsorgan der Gesellschaft f r Biochemie und Molekularbiologie (GBM), der Vereinigung f r Allgemeine und Angewandte Mikrobiologie (VAAM), der Gesellschaft f r Genetik (GfG), der Gesellschaft f r Entwicklungsbiologie (GfE) und der Deutschen Gesellschaft f r Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT), 23 (6), 643-645, ...
Beginn: 21.4.2021 Ende: 23.4.2021 Veranstalter: Friedrich-Loeffler-Institut Standort: Jena Ort: Konferenzraum des Friedrich-Loeffler-Institut
Furtner, M. (2008). Tanz der Neuronen - Optimierte Lernfähigkeit durch effektives Motivations- und Selbstführungsmanagement. Optometrie, 25-29. ...
Buy Meteor - Retina Responsive WordPress Theme by der on ThemeForest. » Meteor 1.0.7 is available. » Demo Content available in the theme package. » Compatible with WordPress 4.0 Enter Met...
In den letzten Jahren werden immer häufiger stark wirksame Opioide für Patienten verordnet, die keine Tumorerkrankung haben. Daher sollte auch der …
49. Jahrestagung der NEUEN GRUPPE; Implantologie im atrophierten Kiefer. Augmentationen, Kurze & Schmale Implantate oder All-on-Four?Welche Therapie passt wann und ist langfristig erfolgreicher?; Wiesbaden; Deutschland; 29.10.2015-31.10.2015
Prvn z znam rostliny zobrazuje parametry p i po zen . Kliknut m na hyperlink uprav je m ete nastavit (samoz ejm pouze ty Va e) a tak p i adit rodov a druhov jm no ...
XY, +20, dup(1)(q21q42), der(2)t(2;14)(q37;q24)t(14;18)(q32;q21), t(8;22)(q24;q11.2), der(14)t(X;14)(p21;p13)t(14;18)(q32;q21), dup(17)(q11q22), der(18)t(14;18)(q32;q21); ...
SP-D increases bacterial antigen presentation by dendritic cells whereas SP-A blocs differentation of the immature dendritic ... Dermatophagoides pteronyssinus) allergens". Clinical and Experimental Immunology. 106 (2): 367-373. doi:10.1046/j.1365- ... "Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells". American Journal of ...
Dermatophagoides farinae antigen. Known as: Antigens, Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides ... Dermatophagoides farinae. Dermatophagoides farinae Ab.IgE:ACnc:Pt:Ser:Qn. Dermatophagoides farinae Ab.IgG4:MCnc:Pt:Ser:Qn. ... Functional human IgE specific for Dermatophagoides farinae antigen is produced in SCID mice reconstituted with peripheral ... GATA-3 and FOXP3 mRNA in asthmatic peripheral blood mononuclear cells stimulated by Dermatophagoides farinae antigen]. ...
Browse by Exposure: Antigens, Dermatophagoides (1 article). % of records by year: 1965 2017 ... Evaluation of IgG subclass responses against Dermatophagoides farinae allergens in healthy and atopic dogs. Vet Dermatol. 2006 ...
Browse by Exposure: Antigens, Dermatophagoides (1 article). % of records by year: 1965 2017 ...
Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides ... Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides ... Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides ... Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides ...
Dermatophagoides" by people in this website by year, and whether "Antigens, Dermatophagoides" was a major or minor topic of ... Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite ... "Antigens, Dermatophagoides" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Antigens, Dermatophagoides" by people in Profiles. ...
from our selection of Antigens and in our online store. ViroGen Corporation is a leading provider of antigens and antibodies to ... Der F1 Recombinant Antigen. Catalog Number: 900-V. Product Description: Dermatophagoides farina Der F1 antigen (recombinant). ... Dermatophagoides farina Der F1 antigen. - $195.00 be the first to write a review ...
Mite allergy is associated with a specific profile of IgG epitopes recognized on antigen p1 of Dermatophagoides pteronyssinus ... Mite allergy is associated with a specific profile of IgG epitopes recognized on antigen p1 of Dermatophagoides pteronyssinus. ... Mite allergy is associated with a specific profile of IgG epitopes recognized on antigen p1 of Dermatophagoides pteronyssinus. ... Immune response to inhaled antigens differs in allergic patients and healthy individuals, mostly in the quality of T cell help ...
Rocklin, R.E., Sheffer, A.L., Grainader, D.K. and Melmon, K.: Generation of antigen-spe-cific suppressor cells during allergy ... Dermatophagoides pteronyssinus. 5000 [AU] in 1 mL. Dermatophagoides farinae (UNII: PR9U2YPF3Q) (Dermatophagoides farinae - UNII ... Dermatophagoides farinae (UNII: PR9U2YPF3Q) (Dermatophagoides farinae - UNII:PR9U2YPF3Q). Dermatophagoides farinae. 10000 [AU] ... Dermatophagoides farinae (UNII: PR9U2YPF3Q) (Dermatophagoides farinae - UNII:PR9U2YPF3Q). Dermatophagoides farinae. 3000 [AU] ...
Atopy was defined by allergen skin-test response to Dermatophagoides pteronyssinus and mixed threshings measured in a one-in- ... Antigens, Dermatophagoides * Asthma / epidemiology* * Bedding and Linens * Child * Child, Preschool * Cough / epidemiology ...
Standardized Mite Dermatophagoides Pteronyssinus official prescribing information for healthcare professionals. Includes: ... particularly when the antigen load from exposure plus the injected antigen exceeds the patients antigen tolerance. ... Dermatophagoides farinae (Dermatophagoides farinae). Dermatophagoides farinae. 5000 [AU] in 1 mL. Dermatophagoides ... Dermatophagoides farinae (Dermatophagoides farinae). Dermatophagoides farinae. 15000 [AU] in 1 mL. Dermatophagoides ...
Antigens, Dermatophagoides / administration & dosage * Antigens, Dermatophagoides / adverse effects * Antigens, ...
... an allergen of Dermatophagoides farinae from China. - Yu-bao Cui, Hong-xing Cai, Ying Zhou, Cui-xiang Gao, Wei-hong Shi, Ming ... Dermatophagoides farinae antigen f 7. Topics. *Amino Acid Sequence. *Animals. *Antigens, Dermatophagoides (genetics, metabolism ... Cloning, expression, and characterization of Der f 7, an allergen of Dermatophagoides farinae from China.. Abstract. A full- ... length cDNA encoding house dust mite allergen Der f 7 from Dermatophagoides farina (Acari: Pyroglyphidae) from China was cloned ...
Specific antigens were of 3 kinds: Dermatophagoides farinae, dog, and cockroach. Antigen-specific IgE levels of ≥0.35 kU/L were ... An increase in Th2 cells leads to increased IL-4 production and leads to increased response to environmental antigens such as ... which exhibits normal tIgE levels in the absence of IgE-mediated sensitization to allergic antigens [3]. The typical symptom of ... levels in the presence of IgE-mediated sensitization to specific allergic antigens, and intrinsic AD, ...
Description: Dermatophagoides farina Der F1 antigen (recombinant). Full length. Non enzymatically active. ... Description: Dermatophagoides farina Der F1 antigen (recombinant). Full length. Non enzymatically active. ... Description: The E.Coli derived recombinant protein contains the Dermatophagoides farina Der F1 full length protein (a.a. 1-320 ... Description: Recombinant Yersinia pestis F1 capsule antigen(caf1) expressed in E.coli ...
Smith, A.P., Hyposensitization with D. pteronyssinus antigen. Trial in asthma induced by house dust. Br. Med. J., 4:204, 1971. ... DERMATOPHAGOIDES FARINAE (UNII: PR9U2YPF3Q) (DERMATOPHAGOIDES FARINAE - UNII:PR9U2YPF3Q). DERMATOPHAGOIDES FARINAE. 10000 [AU] ... DERMATOPHAGOIDES PTERONYSSINUS (UNII: 57L1Z5378K) (DERMATOPHAGOIDES PTERONYSSINUS - UNII:57L1Z5378K). DERMATOPHAGOIDES ... dermatophagoides farinae injection HOUSE DUST MITE, DERMATOPHAGOIDES PTERONYSSINUS- house dust mite, dermatophagoides ...
Antigens, Dermatophagoides. Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They ... Dermatophagoides Pteronyssinus. Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found ... More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the ...
Antigens, Dermatophagoides. Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They ... Dermatophagoides Pteronyssinus. Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found ... More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the ... They include the genera Dermatophagoides and Euroglyphus.. ...
0 (Allergens); 0 (Antigens, Dermatophagoides); 0 (Antigens, Fungal); 37341-29-0 (Immunoglobulin E). ... Ant genos de Dermatophagoides/imunologia. Crian a. Dermatophagoides pteronyssinus/imunologia. Feminino. Seres Humanos. Imuniza ... Ant genos de Dermatophagoides/imunologia. Ant genos de Fungos/imunologia. Gatos/imunologia. Doen a Cr nica. Feminino. Seres ... OBJECTIVES: To standardize the specific NPT with one of the most important house-dust mites, Dermatophagoides pteronyssinus, ...
The plasmid is able to express the encoded antigen in vitro transiently transfected cells. This construct is particularly ... pCMVHuIC80Derp1 plasmid containing the gene encoding for the dust mite allergen of Dermatophagoides pteridissinus (DerP1) fused ... pCMVHuIC80Derp1 plasmid containing the gene encoding for the dust mite allergen of Dermatophagoides pteridissinus (DerP1) fused ... suitable for in vitro studies aimed at analysing the antigen processing and presentation by human APCs, and to evaluate cell ...
Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, comment code. Target: Both males and females 1 YEARS - 150 YEARS. ... Aspergillus fumigatus: (ng antigen/mL)*(1mL/45mg dust)*(1ug antigen/1000 ng antigen)*(1000 mg dust/1 g dust) = ug Aspergillus ... Dust mite Dermatophagoides farinae 1 (Der f 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS - 150 ... Dust mite Dermatophagoides pteronyssinus 1 (Der p 1) dust antigen, result (ng/mL dust). Target: Both males and females 1 YEARS ...
This response was not observed with control antigens or with ordinary scabies and uninfested patient sera. In addition, the ... Glutathione S-transferase a major allergen of the house dust mite, Dermatophagoides pteronyssinus. Immunol Lett 48 : 103-107. ... Identification and mapping of antibody epitopes on a three-dimensional model of the antigen. J Immunol 152 : 1861-1872. ... This response was not observed with control antigens or with ordinary scabies and uninfested patient sera. In addition, the ...
... allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or ... of the house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farinae in their native form as primary antigens ... using the same set of antibody and antigen reagents.. The antigen preparation that was used as a positive control was a mixture ... thefirst is the recognition by the T cell via the T cell receptor of appropriate MHC-associated processed antigens on antigen ...
Chemicals/CAS: Antigens, Dermatophagoides; Dust; Glycoproteins; Immunoglobulin E, 37341-29-0; Immunoglobulin G; Interferon Type ... Antigens, Dermatophagoides · Cells, Cultured · Dust · Female · Glycoproteins · Hypersensitivity, Immediate · Immunoglobulin E ... CD11b antigen · chymase · gamma interferon · granulocyte colony stimulating factor · granulocyte macrophage colony stimulating ... Dermatophagoides pteronyssinus · Immune response · Immunization · Immunomodulation · Lactobacillus plantarum · Mouse · Nonhuman ...
Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blueberry Plant, Vaccinium macrocarpon, Citrullus, Cicer, Prosopis, ... Antigen Laboratories Inc Product Research. Pharma Company Index ,, Address:. 28-36 South Main St. Liberty, MO, 64068. United ... Hepatitis B Surface Antigens (HBsAg), Silk, typhoid Vi polysaccharide vaccine (Typhim Vi), Tilia, Thymus Plant, Solanum ... Standardized Mite Dermatophagoides Farinae Injection - subcutaneous, intradermal (10 ml, 30 ml, 50 ml) Standardized Mite ...
Effects of sequential Dermatophagoides pteronyssinus antigen stimulation on anatomy and physiology of the larynx ...
Publications] Fujii, S.et al.: B cell mitogenic activity of house dust mite,Dermatophagoides farinae,antigens. Immunol.Letter ... Publications] Fujii, S.et al.: B cell mitogenic activity of house dust mite, Dermatophagoides farinae, antigens. Immunol.Lett ... Publications] Fujii,S.et al.: B cell mitogenic activity of house dust mite,Dermatophagoides farinae,antigens. Immunol.Letter ... Publications] Myozaki,M.et al.: Induction of autoimmune hepatitis and autoantibodies to liver antigens by neonatal thymectomy ...
In the present study, we examined the immunological effect of drinking HW on ,i,Dermatophagoides farinae,/i,-induced AD-like ... AD-like skin lesions in NC/Nga mice were performed using mite antigen as described previously [19]. The hair on the back was ... Dermatophagoides farinae (Df) is a cosmopolitan species of house dust mites and a common contributory cause of AD. The topical ... In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae-induced AD-like skin in ...
Allergens/*immunology, Animals, Antigens; Dermatophagoides/*immunology, Bronchoalveolar Lavage Fluid/immunology, ...
Dermatophagoidesfarinae, and mold; Phadiatop, Phadia AB, Uppsala, Sweden) or against food antigens (milk, egg, soy, fish, wheat ... Sensitization to food antigens occurred in 15%, whereas sensitization to inhaled antigens was uncommon (Table 3). ... these are covered by M-cells that are specialized in antigen uptake and delivery to antigen-presenting cells and lymphocytes ... Antigen presentation in the murine oral epithelium. Immunology. 1996;88(1):147-152pmid:8707342. ...
HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 ... Dermatophagoides farinae/gen tica. Dermatophagoides farinae/imunologia. Ant genos de Dermatophagoides/gen tica. Ant genos de ... Ant genos de Dermatophagoides/uso terap utico. Asma/terapia. Dermatophagoides farinae/imunologia. Dermatophagoides ... Dermatophagoides farinae/qu mica. Ant genos de Dermatophagoides/qu mica. -Tubulina (Prote na)/gen tica. Tubulina (Prote na)/ ...
  • The physicochemical and antigenic properties of an allergen purified from Dermatophagoides farinae, Der f I, were compared with Der p I from Dermatophagoides pteronyssinus. (jimmunol.org)
  • Atopy was defined by allergen skin-test response to Dermatophagoides pteronyssinus and mixed threshings measured in a one-in-four subsample of those aged 5 years and older from both groups. (nih.gov)
  • Cloning, expression, and characterization of Der f 7, an allergen of Dermatophagoides farinae from China. (curehunter.com)
  • A full-length cDNA encoding house dust mite allergen Der f 7 from Dermatophagoides farina (Acari: Pyroglyphidae) from China was cloned, sequenced, and successfully expressed. (curehunter.com)
  • Publications] Kawamoto S.: 'Der f 16 : a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae'FEBS Lett. (nii.ac.jp)
  • In general, vitamin E supplementation was associated with a trend for reduced proliferative responses after stimulation with antigens and house dust mite, and with increased proliferation after stimulation with timothy grass allergen. (mdpi.com)
  • Continuous exposure of nonallergic beekeepers to high doses of bee venom antigens induces diminished T cell-related cutaneous late-phase swelling to bee stings in parallel with suppressed allergen-specific T cell proliferation and T helper type 1 (Th1) and Th2 cytokine secretion. (rupress.org)
  • In addition, cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 play roles in allergen-specific T cell suppression. (rupress.org)
  • Zurück zum Zitat King C, Simpson RJ, Moritz RL, Reed GE, Thompson PJ, Stewart GA. The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus. (springermedizin.de)
  • Structural studies on the allergen Der p1 from the house dust mite Dermatophagoides pteronyssinus: similarity with cysteine proteinases. (edu.au)
  • A major allergen (Der p1) has been purified to homogeneity from faecal particles from the house dust mite Dermatophagoides pteronyssinus. (edu.au)
  • Vaccination with a mixture of two fused recombinant antigen portions [Ssag1 (homologous to the house dust mite Euroglyphus maynei allergen M-177, an apolipoprotein from hemolymph) and Ssag2] in a rabbit/ S. scabiei var. (biomedcentral.com)
  • To obtain the recombinant group 2 allergen product of Dermatophagoides farinae (Der f 2), the Der f 2 gene was synthesized by RT-PCR. (bvsalud.org)
  • Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. (ucdenver.edu)
  • Dermatophagoides farinae (Df) is a cosmopolitan species of house dust mites and a common contributory cause of AD. (hindawi.com)
  • The scabies mite Sarcoptes scabiei and the Dermatophagoides house dust mites (HDM) are related phylogenetically and are the sources of several cross-reactive antigens. (ajtmh.org)
  • Serological tests using the total antigen are labour intensive and expensive to produce, and moreover there exist unspecific crossreactions against house dust mites, which lead to false positive results. (hu-berlin.de)
  • We expect an improvement of serological diagnosis using specific recombinant antigens of the Sarcoptes-mites. (hu-berlin.de)
  • By southern blot analysis we could show one copy of the gene, while it was not detected in the genome of the free-living Dermatophagoides-mites. (hu-berlin.de)
  • As for the specificity for the parasitic mites, the antigens might be good candidates for immunodiagnosis. (hu-berlin.de)
  • All twelve dogs were sensitized epicutaneously to Dermatophagoides farinae (Df) house dust mites and then challenged twice epicutaneously with the mite. (uzh.ch)
  • The purpose of this study was to determine the percentage of dogs with spontaneous atopic dermatitis that show a positive patch test reaction to a commercially available 20% house dust mites mixture containing equal parts of Dermatophagoides farinae and Dermatophagoides pteronyssinus in white petrolatum. (vetcontact.com)
  • Surveys of houses in South Africa have shown that dust mites and mite-derived antigens are more common along the eastern and southern coastal lowlands than on the central Highveld plateau. (who.int)
  • Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides pteronyssinus and epitope specificity of murine IgG and human IgE antibodies. (jimmunol.org)
  • However, ELISA with partially purified antigen (JEA-1) did not give better sensitivity or specificity than the crude extract. (springer.com)
  • McLaren ML, Lillywhite JE, Dunne DW, Doenhoff MJ (1981 Serodiagnosis of human Schistosoma mansoni infections: enhanced sensitivity and specificity in ELISA using a fraction containing S. mansoni egg antigens w1 and a1. (springer.com)
  • Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus]. (nih.gov)
  • A great deal of uncertainty remains about differentiation factors, antigen specificity, and mechanisms of action of T reg cells. (rupress.org)
  • However, while different in many functional aspects, both groups of T cells shared the capacity to support the synthesis of antigen-specific immunoglobulin G (IgG) antibodies detected in different amounts in the serum of atopic and healthy individuals. (docphin.com)
  • The antibodies of subjects allergic to a bacterial antigen included IgE and IgG4 (particularly for males) compared with the almost exclusive IgG1 response of non-allergic subjects. (bmj.com)
  • To study immune responses to an antigen presented at the respiratory mucosa, the IgE and IgG subclass antibodies induced by a conserved outer membrane protein of Haemophilus influenzae has been examined. (bmj.com)
  • however, some antibodies were directed at scabies-specific antigens. (ajtmh.org)
  • [email protected]#To evaluate the efficacy of sublingual immunotherapy with dermatophagoides farina drops on children with allergic rhinitis. (bvsalud.org)
  • An effect on responses to other antigens could also be expected. (bmj.com)
  • 14 The studies here have used assays with defined polypeptide antigens to provide quantitative assays and to differentiate the anti-protein antigen responses from the lipopolysaccharides. (bmj.com)
  • From the literature on breastfeeding prevention of immune-mediated disease and more specifically from our experiments conducted in the field of allergic disease prevention, we propose that breastfeeding may also induce antigen-specific immune responses in the breastfed child. (royalsocietypublishing.org)
  • Further research in this direction may lead to novel strategies of early life vaccination, taking advantage of the possibility to stimulate antigen-specific immune responses through breast milk. (royalsocietypublishing.org)
  • We show here that the depletion of CD301b + DCs specifically enhanced the development of Tfh cells, germinal center B cells and antibody responses against protein antigens. (elifesciences.org)
  • Through presenting processed antigens on their MHC molecules, dendritic cells (DCs) are primarily responsible for initiating T cell-mediated cellular immunity, which is also required for T cell-dependent antibody responses. (elifesciences.org)
  • However, these results pave the way for future studies on alternative production systems, adjuvants, delivery methods and combinations of antigens in order to manage stimulation of clinical protective immune responses. (biomedcentral.com)
  • We and other have shown that the lack of gut microbiota in germ free mice is associated with the development of Th2 and IgE responses to dietary antigens [ 11 , 12 ]. (intechopen.com)
  • Publications] Tategaki: 'Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from-macrophages stimulated with high molecular size mite antigen HM1'Int Arch Allergy Immunol. (nii.ac.jp)
  • Publications] Tategaki A.: 'Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces'Int Arch Allergy Immunol. (nii.ac.jp)
  • This interesting study describes the results of patch tests with house dust mite antigen in 13 dogs with atopic dermatitis. (vetcontact.com)
  • T cell regulation continues as long as antigen exposure persists and returns to initial levels within 2 to 3 mo after bee stings. (rupress.org)
  • We found that early oral antigen exposure through breast milk leads to tolerance or immune priming depending on the nature of the antigen transferred and accompanying maternal milk cofactors. (royalsocietypublishing.org)
  • The selected antigens delivered as recombinant proteins had no clinical protective efficacy against S. scabiei infestation although immunisation reduced mite density. (biomedcentral.com)
  • The identification of antigen-producing genes, candidate immune modulating proteins and pathways, and genes responsible for acaricide resistance offers opportunities for developing new methods for diagnosing, treating and preventing this disease. (biomedcentral.com)
  • Six of the nine retrospective patients were SPT positive to both S. scabiei and HDM and two of these showed circulating IgE specific for these antigens. (ajtmh.org)
  • Six patients had circulating IgE directed at both S. scabiei and HDM antigens while one subject had IgE to S. scabiei only and another had IgE directed at HDM only. (ajtmh.org)
  • In this study, recombinant antigens of S. scabiei were produced and tested for the use in immunodiagnosis. (hu-berlin.de)
  • The purpose of this study was first to identify Sarcoptes scabiei immunodominant antigens and second to evaluate them as vaccine candidates in a rabbit/ S. scabiei var. (biomedcentral.com)
  • The S. scabiei Ssλ15 immunodominant antigen was selected by immunoscreening of a S. scabiei var. (biomedcentral.com)
  • Crude antigen for ELISA is usually prepared from S. scabiei var. (usda.gov)
  • Atopic dermatitis is a chronic inflammatory skin disease caused by environmental antigens that in nonatopic animal create no disease. (vin.com)
  • Complex interactions between T and B lymphocytes and antigen presenting cells (APC) lead to inflammation, cytokine production, IgE production, and bronchial hyperresponsiveness (BHR). (bmj.com)
  • To avoid chronic cell activation and inflammation against nonpathogenic antigens through skin, ingestion, and inhalation, the immune system has developed efficient peripheral tolerance mechanisms. (rupress.org)
  • Antigen challenge decreased pulmonary function and induced airway inflammation, evoked HPA axis response in sensitized rats. (biomedcentral.com)
  • There exist significant differences between the reactions of the positive and negative sera for all the seven antigens using human sera. (hu-berlin.de)
  • The swine workers with positive skin reactions to swine confinement antigens had a higher prevalence of chronic cough, phlegm, and bronchitis than those with negative results. (cdc.gov)
  • SP-D increases bacterial antigen presentation by dendritic cells whereas SP-A blocs differentation of the immature dendritic cells. (wikipedia.org)
  • Proveer evidencia sobre los cambios relacionados con la calidad de vida inducidos por la inmunoterapia subcut nea en sujetos con alergia respiratoria. (bireme.br)
  • Objetivo: Determinar sensibilidad y especificidad de la prueba epicutánea modificada para el diagnóstico de alergia respiratoria a Dermatophagoides pteronyssinus. (nih.gov)
  • Se incluyeron pacientes de seis a 49 años de edad, con cuadro clínico de alergia respiratoria, en quienes se realizó punción cutánea con técnica europea y prueba epicutánea con la variante de escarificación previa a la aplicación del antígeno y posterior homogenización del mismo con aplicador de madera. (nih.gov)
  • Ovalbumin-sensitized rats were challenged by inhalation of antigen. (biomedcentral.com)
  • The World Health Organization has established standard reference extracts for the group I and II antigens, which enable assays carried out in different laboratories to be standardised. (newscientist.com)
  • The two fungal antigens ( Alternaria alternata and Aspergillus fumigatus ) measured are primarily outdoor antigens, which are transported into the indoor environment. (cdc.gov)
  • In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae -induced AD-like skin in NC/Nga mice. (hindawi.com)
  • A micromethod of the enzyme-linked immunosorbent assay (ELISA) was applied to infections with Schistosoma japonicum in humans and mice with egg antigens. (springer.com)
  • For the in vivo model of Blomia tropicalis-induced allergy, mice transplanted with antigen-pulsed TolDCs were sensitized intraperitoneally with B. tropicalis mite extract (BtE) adsorbed to aluminium hydroxide. (bvsalud.org)
  • The subjects were prick tested with extracts of materials collected in the swine confinement building such as swine food, corn flour, swine hair, and bacterial, mold, and Dermatophagoides-pteronyssinus antigens. (cdc.gov)
  • Antigens, Dermatophagoides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Expression of T-bet, GATA-3 and FOXP3 mRNA in asthmatic peripheral blood mononuclear cells stimulated by Dermatophagoides farinae antigen]. (semanticscholar.org)
  • The plasmid is able to express the encoded antigen in vitro transiently transfected cells. (europa.eu)
  • Complete activation of T cells requires an antigen specific signal transduced by the T cell receptor and an antigen non-specific co-stimulatory signal (fig 1 ). (bmj.com)
  • After multiple bee stings, venom antigen-specific Th1 and Th2 cells show a switch toward interleukin (IL) 10-secreting type 1 T regulatory (Tr1) cells. (rupress.org)
  • In addition to the HLA antigens received genetically, children are exposed to maternal non-inherited allo-antigens (NIMA) that are present in breast milk in soluble forms or expressed on milk cells [ 11 ]. (royalsocietypublishing.org)
  • Carter CE, Colley DG (1981) Schistosoma japonicum soluble egg antigens: Separation by ConA chromatography and immunoaffinity purification. (springer.com)
  • Mittels der Southern Blot-Analyse konnte in Sarcoptes nur eine Genkopie detektiert werden, während dieses Gen in Dermatophagoides-Milben nicht nachgewiesen werden konnte. (hu-berlin.de)
  • It was shown, that the E. coli-expression system might be unsuitable for the production of recombinant antigens for their use in immunodiagnosis of Sarcoptes-infections. (hu-berlin.de)
  • Immune response to inhaled antigens differs in allergic patients and healthy individuals, mostly in the quality of T cell help provided (i.e. (docphin.com)
  • Here, we will discuss our data in the light of prevention of infectious disease and will propose that possible milk transfer of microbial antigen could affect actively the immune response in breastfed children and thereby their long-term susceptibility to infectious disease. (royalsocietypublishing.org)
  • Description: The E.Coli derived recombinant protein contains the Dermatophagoides farina Der F1 full length protein (a.a. 1-320) and fused to a 6 His Tag at C-terminus, having a total Mw of 36kDa, pI 5.88. (ascn.org)
  • Unspezifische Reaktionen mit E. coli-Protein sowie GST bei einem als Fusionsprotein exprimierten Antigen erwiesen sich als störend. (hu-berlin.de)
  • Expression of CRH mRNA and protein in hypothalamus were also significantly increased by LTB 4 via i.c.v in sensitized rats after antigen challenge. (biomedcentral.com)
  • In this sense, different recombinant antigens have been identified and assayed as vaccine candidates which have not conferred complete protection. (biomedcentral.com)
  • The included patients were between 6 and 49 years old, with symptoms of a respiratory allergy, and a skin test was performed on them by using the European standardized prick test and a modified epicutaneous patch test with the variable of the scarification that occurred before the antigen was applied, and its homogenization with a wooden applicator, which occurred after the antigen was applied. (nih.gov)
  • Our previous studies showed corresponding changes of cytokines and leukotriene B 4 (LTB 4 ) between brain and lung tissues in antigen-challenged asthmatic rats. (biomedcentral.com)
  • Here, we investigated how the increased LTB 4 level in brain interacts with HPA axis in regulating antigen-induced asthmatic response in sensitized rats. (biomedcentral.com)
  • AD is classified into extrinsic AD, which exhibits elevated total IgE (tIgE) levels in the presence of IgE-mediated sensitization to specific allergic antigens, and intrinsic AD, which exhibits normal tIgE levels in the absence of IgE-mediated sensitization to allergic antigens [ 3 ]. (hindawi.com)
  • Tc-specific IgE and IgG against Tc L3 E/S antigen (TcE/S antigen) were measured before and after Tc infection. (uzh.ch)
  • This construct is particularly suitable for in vitro studies aimed at analysing the antigen processing and presentation by human APCs, and to evaluate cell activation upon DNA uptake. (europa.eu)
  • We have been using a mouse model of antigen transfer through breast milk in order to understand how to stimulate immune regulation in early life by oral tolerance induction to improve allergic disease prevention. (royalsocietypublishing.org)
  • Mite extract is a sterile solution containing the extractables of Dermatophagoides farinae or Dermatophagoides pteronyssinus, 0.5% sodium chloride, 0.275% sodium bicarbonate, and 50% glycerin by volume as a preservative. (drugs.com)
  • Tracheal explants from male Hartley-guinea-pigs were incubated with 0 to 100 microliters of a extract of a mixture of swine hair, pig food, and swine confinement building antigens. (cdc.gov)
  • Mite-allergic sera showed a higher degree of binding to nDer p1 than to dDer p1, whereas control sera and mite-sensitized sera bound at a similar level to the two forms of the antigen. (docphin.com)
  • This response was not observed with control antigens or with ordinary scabies and uninfested patient sera. (ajtmh.org)
  • In contrast, with the porcine sera, significant difference could be detected only in four antigens. (hu-berlin.de)
  • We choose to assess the immunological outcome of oral antigen administration through breast milk, but not given directly, to include in our research the analysis of the potential impact of maternal milk cofactors on neonate immune regulation. (royalsocietypublishing.org)