Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. (1/4475)
BACKGROUND: The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis. RESULTS: We generated mice lacking the JNK2 isozymes. The mutant mice were healthy and fertile but defective in peripheral T-cell activation induced by antibody to the CD3 component of the T-cell receptor (TCR) complex - proliferation and production of interleukin-2 (IL-2), IL-4 and interferon-gamma (IFN-gamma) were reduced. The proliferation defect was restored by exogenous IL-2. B-cell activation was normal in the absence of JNK2. Activation-induced peripheral T-cell apoptosis was comparable between mutant and wild-type mice, but immature (CD4(+) CD8(+)) thymocytes lacking JNK2 were resistant to apoptosis induced by administration of anti-CD3 antibody in vivo. The lack of JNK2 also resulted in partial resistance of thymocytes to anti-CD3 antibody in vitro, but had little or no effect on apoptosis induced by anti-Fas antibody, dexamethasone or ultraviolet-C (UVC) radiation. CONCLUSIONS: JNK2 is essential for efficient activation of peripheral T cells but not B cells. Peripheral T-cell activation is probably required indirectly for induction of thymocyte apoptosis resulting from administration of anti-CD3 antibody in vivo. JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells. (+info)Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21. (2/4475)
The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell death signaling. We recently reported that activation of caspase 3 is regulated by complex formation with p21 or ILP. In the present study, we investigated the binding domain with p21 and ILP to further characterize the caspase 3 inactivation machinery. Our results show that caspase 3 contains p21 binding domain in the N-terminus and ILP binding domain in the active site. Further, the caspase 3 binding domain in p21 was independent of the Cdk- or PCNA-binding domain. We also found caspase 3 protection by p21 from the p3-site cleavage serineproteinase contributes to the suppression machinery. Here, we propose the caspase 3 inactivation system by p21 and ILP as new essential system in the regulation of cell death. (+info)Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. (3/4475)
Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis. Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis. Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process. To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation. Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation. Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation. Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286. Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation. Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50. The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha. Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction. (+info)Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL). (4/4475)
Fas ligand is a type II transmembrane protein which can induce apoptosis in Fas-expressing cells. Recent reports indicate that expression of FasL in transplanted cells may cause graft rejection and, on the other hand, tumor cells may lose their tumorigenicity when they are engineered to express FasL. These effects could be related to recruitment of neutrophils by FasL with activation of their cytotoxic machinery. In this study we investigated the antitumor effect of allogenic fibroblasts engineered to express FasL. Fibroblasts engineered to express FasL (PA317/FasL) did not exert toxic effects on transformed liver cell line (BNL) or colon cancer cell line (CT26) in vitro, but they could abrogate their tumorigenicity in vivo. Histological examination of the site of implantation of BNL cells mixed with PA317/FasL revealed massive infiltration of polymorphonuclear neutrophils and mononuclear cells. A specific immune protective effect was observed in animals primed with a mixture of BNL or CT26 and PA317/FasL cells. Rechallenge with tumor cells 14 or 100 days after priming resulted in protection of 100 or 50% of animals, respectively. This protective effect was due to CD8+ cells since depletion of CD8+ led to tumor formation. In addition, treatment of pre-established BNL tumors with a subcutaneous injection of BNL and PA317/FasL cell mixture at a distant site caused significant inhibition of tumor growth. These data demonstrate that allogenic cells engineered with FasL are able to abolish tumor growth and induce specific protective immunity when they are mixed with neoplastic cells. (+info)Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. (5/4475)
The developing cerebral cortex undergoes a period of substantial cell death. The present studies examine the role of the suicide receptor Fas/Apo[apoptosis]-1 in cerebral cortical development. Fas mRNA and protein are transiently expressed in subsets of cells within the developing rat cerebral cortex during the peak period of apoptosis. Fas-immunoreactive cells were localized in close proximity to Fas ligand (FasL)-expressing cells. The Fas-associated signaling protein receptor interacting protein (RIP) was expressed by some Fas-expressing cells, whereas Fas-associated death domain (FADD) was undetectable in the early postnatal cerebral cortex. FLICE-inhibitory protein (FLIP), an inhibitor of Fas activation, was also expressed in the postnatal cerebral cortex. Fas expression was more ubiquitous in embryonic cortical neuroblasts in dissociated culture compared to in situ within the developing brain, suggesting that the environmental milieu partly suppresses Fas expression at this developmental stage. Furthermore, FADD, RIP, and FLIP were also expressed by subsets of dissociated cortical neuroblasts in culture. Fas activation by ligand (FasL) or anti-Fas antibody induced caspase-dependent cell death in primary embryonic cortical neuroblast cultures. The activation of Fas was also accompanied by a rapid downregulation of Fas receptor expression, non-cell cycle-related incorporation of nucleic acids and nuclear translocation of the RelA/p65 subunit of the transcription factor NF-kappaB. Together, these data suggest that adult cortical cell number may be established, in part, by an active process of receptor-mediated cell suicide, initiated in situ by killer (FasL-expressing) cells and that Fas may have functions in addition to suicide in the developing brain. (+info)Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis. (6/4475)
The molecular mechanisms of resistance to genital infection with the mouse pneumonitis (MoPn) strain of Chlamydia trachomatis are unknown. A role for major histocompatibility complex class II-restricted, interleukin-12-dependent CD4(+) T cells has been established, but the functional activity of these cells does not depend on secretion of gamma interferon. Here we examined the potential contribution of T-cell-mediated cytotoxicity and apoptosis to mucosal clearance of MoPn by using mice deficient in the molecular mediators of target cell lysis. Animals lacking perforin, Fas, Fas ligand, or both perforin and Fas ligand were infected genitally with C. trachomatis MoPn and monitored for expression of immunity to chlamydial antigens and clearance of MoPn from the genital mucosa. In each case, the profile of spleen cytokine production, the magnitude of the host antibody response, and the kinetics of chlamydial clearance were similar to those of genetically intact controls. Compensatory overproduction of tumor necrosis factor alpha, an alternate mediator of apoptosis in certain cell types, did not appear to account for the ability of mutant mice to resolve Chlamydia infections. These results fail to support CD4(+) T-cell-mediated apoptosis or CD8(+) T-cell-mediated cytotoxicity as being critical to the clearance of C. trachomatis MoPn urogenital infections. (+info)In vitro induction of activation-induced cell death in lymphocytes from chronic periodontal lesions by exogenous Fas ligand. (7/4475)
Periodontitis is a chronic inflammatory disease which gradually destroys the supporting tissues of the teeth, leading to tooth loss in adults. The lesions are characterized by a persistence of inflammatory cells in gingival and periodontal connective tissues. To understand what mechanisms are involved in the establishment of chronic lesions, we hypothesized that infiltrating lymphocytes might be resistant to apoptosis. However, both Bcl-2 and Bcl-xL were weakly detected in lymphocytes from the lesions, compared with those from peripheral blood, suggesting that these cells are susceptible to apoptosis. Nevertheless, very few apoptotic cells were observed in tissue sections from the lesions. Lymphocytes from the lesions expressed mRNA encoding Fas, whereas Fas-ligand mRNA was very weakly expressed in lymphocytes from the lesions and in periodontal tissues. Since the results indicated that lymphocytes in the lesions might be susceptible to Fas-mediated apoptosis but lack the death signal, we next investigated if these lymphocytes actually undergo apoptosis by the addition of anti-Fas antibodies in vitro. Fas-positive lymphocytes from the lesions underwent apoptosis by these antibodies, but Fas-negative lymphocytes and Fas-positive peripheral lymphocytes did not undergo apoptosis by these antibodies. These results indicate that lymphocytes in the lesions are susceptible to activation-induced cell death and are induced to die by apoptosis after the addition of exogenous Fas ligand. (+info)Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies: CD4+ T cells cause muscle cell injury directly in polymyositis. (8/4475)
OBJECTIVE: To investigate the involvement of the Fas/Fas ligand (Fas/FasL) system in the inflammatory myopathies. METHODS: Frozen muscle sections obtained from 7 patients with polymyositis (PM), 4 patients with dermatomyositis (DM), and 3 controls were studied by immunochemistry. Apoptosis was detected by DNA electrophoresis and in situ labeling using the TUNEL method. RESULTS: Fas was detected on muscle fibers and infiltrating mononuclear cells (MNC) in 6 PM patients and 2 DM patients. FasL was expressed mainly on CD4+ T cells and some CD8+ T cells, and on macrophages surrounding Fas-positive muscles in 4 PM patients and 1 DM patient. In 3 of the 5 patients with FasL-positive MNC, the TUNEL method showed that both invaded myonuclei and MNC underwent apoptosis. Chromosomal DNA from the muscle tissue of these patients showed ladder formation. CONCLUSION: Fas/FasL is involved in muscle cell apoptosis in at least 2 of the inflammatory myopathies, PM and DM. Although CD8+-mediated cytotoxicity is thought to be the main mechanism of muscle injury in PM, our data suggest that CD4+ T cells also directly cause muscle cell damage. (+info)
Apoptosis induced in human colorectal carcinoma by anti-fas antibody | SpringerLink
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Fas receptor
The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor ... Thus, the name Fas is derived from FS-7-associated surface antigen. The Fas receptor is a death receptor on the surface of ... Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region ... Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics. 14 ( ...
Mycoplasma alligatoris
... working together as potential promoters of the expression of CD95 (FasR). CD95 is a protein involved in mediated cell death of ... Mycoplasma crocodyli is much less virulent than M. alligatoris, lacking the genes for adhesins, variable surface antigens, and ... Hunt, M. E.; Brown, D. R. (2005-12-01). "Mycoplasma alligatoris Infection Promotes CD95 (FasR) Expression and Apoptosis of ... increasing CD95 expression leading to cell death. Experimental inoculation of American alligators (Alligator mississippienis), ...
Memory T cell
Antigen-specific memory T cells specific to viruses or other microbial molecules can be found in both central memory T cells ( ... but they also express large amounts of CD95, IL-2Rβ, CXCR3, and LFA-1, and show numerous functional attributes distinctive of ... After antigen clearance, some of these effector cells form memory T cells, either in a randomly determined manner or are ... Through frequent antigen exposure, the population of memory T cells accumulates. This is the memory generation stage, which ...
Index of biochemistry articles
CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion molecule - cell biology - cell cycle ... T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - TATA box - ... carcinoembryonic antigen - carrier - carrier protein - CAS registry number - casein - catabolism - catalyst - catalytic domain ... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ...
List of MeSH codes (D23)
... antigens, cd95 MeSH D23.050.301.264.035.198 - antigens, cd98 MeSH D23.050.301.264.035.198.500 - antigens, cd98 heavy chain MeSH ... antigens, cd95 MeSH D23.101.100.110.198 - antigens, cd98 MeSH D23.101.100.110.198.500 - antigens, cd98 heavy chain MeSH D23.101 ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ... forssman antigen MeSH D23.050.285.018 - antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, ...
RBM5
1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456-464. doi ... 2000). "LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis". Oncogene. 19 (33): 3774-3781. doi:10.1038/sj.onc. ...
Centroblast
In the absence of FDC and helper T cell stimulation, centroblasts are unable to differentiate and will undergo CD95-mediated ... Centroblasts do not express immunoglobulins and are unable to respond to the follicular dendritic cell antigens present in the ... allowing the B cell receptor to potentially gain stronger affinity for an antigen. ...
HLA-B44
The serotype identifies the B*44 gene-allele protein products of HLA-B. B44 is a split antigen of the broad antigen B12, and is ... "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS ... November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA ... Tissue Antigens. 75 (4): 291-455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336. derived from IMGT/HLA ...
CD154
... +Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD40LG genome location and CD40LG ... Cleary AM, Fortune SM, Yellin MJ, Chess L, Lederman S (October 1995). "Opposing roles of CD95 (Fas/APO-1) and CD40 in the death ... B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total ...
Aplastic anemia
Because it infects red blood cells as a result of the affinity for the P antigen, parvovirus causes complete cessation of red ... CD95, and CCR4; lower expression of CD45RA (mean age: 45 years); and expression of the IL‐2/STAT5 pathway. Higher frequency of ... In humans, the P antigen (also known as globoside), one of many cellular receptors that contribute to a person's blood type, is ... Several kinectin-derived peptides can be processed and presented by HLA I and can induce antigen-specific CD8+ T-cell responses ...
Activation-induced cell death
1(3):186-92 Kabelitz D, Janssen O. (1997), Antigen-induced death of T-lymphocytes. Front Biosci. 2:d61-77 Green DR, Droin N, ... AICD (activation-induced cell death) is programmed cell death caused by the interaction of Fas receptors (Fas, CD95) and Fas ... 1999é, The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem 274:1541-1548 (Cell biology). ... ligands (FasL, CD95 ligand). AICD is a negative regulator of activated T lymphocytes that results from repeated stimulation of ...
Asunercept
... blocks the CD95-ligand (CD95L) from binding to the CD95-receptor (CD95), which induces apoptosis. In oncology, this ... Lakins MA, Ghorani E, Munir H, Martins CP, Shields JD (2018). "Cancer-associated fibroblasts induce antigen-specific deletion ... Asunercept (INN; development code APG101) is a soluble CD95-Fc fusion protein which is in clinical development for the ... a CD95-Fc fusion protein, in healthy volunteers and two glioma patients". Int Immunopharmacol. 13 (1): 93-100. doi:10.1016/j. ...
List of MeSH codes (D12.776.543)
... antigens, cd30 MeSH D12.776.543.750.705.852.760.097 - antigens, cd40 MeSH D12.776.543.750.705.852.760.195 - antigens, cd95 MeSH ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ... antigens, cd22 MeSH D12.776.543.550.200.124 - antigens, cd24 MeSH D12.776.543.550.200.131 - antigens, cd31 MeSH D12.776.543.550 ... antigens, cd11a MeSH D12.776.543.750.705.408.100.150 - antigens, cd11b MeSH D12.776.543.750.705.408.100.200 - antigens, cd11c ...
Death receptor 3
TNFRSF25 is activated by a monogamous ligand, known as TL1A (TNFSF15), which is rapidly upregulated in antigen presenting cells ... Apo-1/CD95)". Immunity. 6 (1): 79-88. doi:10.1016/S1074-7613(00)80244-7. PMID 9052839. Kitson J, Raven T, Jiang YP, Goeddel DV ... Similarly, because TNFRSF25 activation is antigen dependent, costimulation of TNFRSF25 together with an autoantigen or with a ... This receptor is expressed preferentially by activated and antigen-experienced T lymphocytes. TNFRSF25 is also highly expressed ...
PRPF40A
1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456-64. doi: ... 2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction ...
Death domain
APO-1/CD95) death domain". Nature. 384 (6610): 638-41. Bibcode:1996Natur.384..638H. doi:10.1038/384638a0. PMID 8967952. S2CID ... on the cell surface from presenting antigens to immune cells. Many of these malignancies have a subset of cases harboring ... cell apoptosis that occurs via the CD95 pathway, a transmembrane protein, is found to be vital in controlling the proliferation ...
INPP5D
A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23 ... "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis". Journal of ... A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23 ... "Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation". Molecular and Cellular Biology. 22 ...
Cancer immunology
These tumor antigens are either TSA (Tumor-specific antigen) or TAA (Tumor-associated antigen). Tumor-specific antigens (TSA) ... Peter ME, Hadji A, Murmann AE, Brockway S, Putzbach W, Pattanayak A, Ceppi P (April 2015). "The role of CD95 and CD95 ligand in ... Oncofetal antigens are tumor-associated antigens expressed by embryonic cells and by tumors. Examples of oncofetal antigens are ... role of antigen load, antigen-presenting cells, and cytokines". Journal of Immunology. 163 (1): 130-6. PMID 10384108. Scheffer ...
Fas ligand
Parlato S, Giammarioli AM, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S (October 2000). "CD95 ( ... Lakins MA, Ghorani E, Munir H, Martins CP, Shields JD (2018). "Cancer-associated fibroblasts induce antigen-specific deletion ... or CD95, is the most intensely studied member of the death receptor family. The gene is situated on chromosome 10 in humans and ... CD95)-Fas ligand interaction". J. Biol. Chem. 272 (30): 18827-33. doi:10.1074/jbc.272.30.18827. PMID 9228058. Yu KY, Kwon B, Ni ...
List of primary immunodeficiencies
CD95 defects), type 1b (Fas ligand defects), type 2a (CASP10 defects), type 2b (CASP8 defects) (b) APECED (autoimmune ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...
Cytotoxic T cell
If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell ... CD95) molecules expressed on the target cell. However, this Fas-Fas ligand interaction is thought to be more important to the ... The antigen could be any exogenous antigen, such as viral proteins, or an endogenous protein. Recently, a number of possible ... Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is a molecule capable ...
Microvesicles
CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... Microvesicles from various tumor types can express specific cell-surface molecules (e.g. FasL or CD95) that induce T-cell ... This mechanism of action can be used in processes such as antigen presentation, where MHC molecules on the surface of ... For example, those released from antigen-presenting cells (APCs), such as B cells and dendritic cells, are enriched in proteins ...
FNBP1
"Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. 519 (1-3): 50-8 ... "Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma". Cancer Immunol. Immunother ... "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. 519 (1-3): 50-8 ...
CD40 (protein)
The B cell can present antigens to helper T cells. If an activated T cell recognizes the peptide presented by the B cell, the ... CD95 and IL-1". Nature. 385 (6616): 540-4. doi:10.1038/385540a0. PMID 9020361. S2CID 4366355. Hu HM, O'Rourke K, Boguski MS, ... The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects ... Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen-presenting cells and is required for their ...
GRAP2
"Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling ... "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction ...
FADD
... is essential for T cell proliferation when the T cell receptor is stimulated by antigen. In contrast, FADD has no effect ... Scaffidi, C.; Schmitz, I.; Krammer, P. H.; Peter, M. E. (1999). "The role of c-FLIP in modulation of CD95-induced apoptosis". ... Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW (1996). "NMR structure and mutagenesis of the Fas (APO-1/CD95) death ... Pruul H, McDonald PJ (1995). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling ...
Natural killer cell
... which subsequently enables antigen-specific T and B cell responses. Instead of acting via antigen-specific receptors, lysis of ... CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy". Journal of Translational Medicine. 20 (1): 151. doi:10.1186/ ... In contrast to NKT cells, NK cells do not express T-cell antigen receptors (TCR) or pan T marker CD3 or surface immunoglobulins ... MHC class I molecules are the main mechanism by which cells display viral or tumor antigens to cytotoxic T cells. A common ...
Cell death
Activation-induced cell death (AICD) is a programmed cell death caused by the interaction of Fas receptor (Fas, CD95)and Fas ... 1(3):186-92 Kabelitz D, Janssen O. (1997), Antigen-induced death of T-lymphocytes. Front Biosci. 2:d61-77 "Oncosis". Retrieved ... ligand (FasL, CD95 ligand). It occurs as a result of repeated stimulation of specific T-cell receptors (TCR) and it helps to ...
FYN
"Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular ... "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction ...
CD69
Bezouska K, Nepovím A, Horváth O, Pospísil M, Hamann J, Feizi T (March 1995). "CD 69 antigen of human lymphocytes is a calcium- ... identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling". ... Hamann J, Fiebig H, Strauss M (June 1993). "Expression cloning of the early activation antigen CD69, a type II integral ... Ziegler SF, Ramsdell F, Alderson MR (September 1994). "The activation antigen CD69". Stem Cells. 12 (5): 456-65. doi:10.1002/ ...
Survivin
... has been a target of attention in recent years for cancer immunotherapy, as it is an antigen that is expressed mostly ... An example of a TNF receptor is Fas (CD95), which recruits activator caspases like caspase-8 upon binding TNF at the cell ... In acquiring the humoral response to tumour antigens such as survivin, CD4+ T cells are activated to induce B cells to produce ... There has been much evidence accumulated over the years that shows survivin as a strong T-cell-activating antigen, and clinical ...
Immunoglobulin therapy
By binding to receptors on antigen presenting cells, IVIG can increase the expression of the inhibitory Fc receptor, FcgRIIB, ... October 1998). "Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin". Science. ... except that the donor has high titers of antibody against a specific organism or antigen in their plasma. Some agents against ... unable to respond to antigens as they normally should - resulting in an increased rate or increased severity of infections. In ...
GRB2
Engels N, Wollscheid B, Wienands J (July 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM ... "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction ... Pandey P, Kharbanda S, Kufe D (September 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras ... Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (August 1995). "Ligation of the T-cell antigen receptor (TCR) induces ...
Plectin
List of target antigens in pemphigus GRCh38: Ensembl release 89: ENSG00000178209 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... "Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis ...
Fas (CD95, APO-1) antigen expression and function in murine mast cells - edoc
Fas (CD95, APO-1) antigen expression and function in murine mast cells. Journal of Immunology, 159 (8). pp. 4006-4014. ... Fas (CD95, APO-1) antigen expression and function in murine mast cells ... CD95, APO-1), thus providing an additional pathway that could contribute to the regulation of mast cell numbers. Surface ...
FAS gene: MedlinePlus Genetics
português
Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease<...
Expression of CD95 antigen and Bcl-2 protein in non-Hodgkins lymphomas and Hodgkins disease. American Journal of Pathology. ... Expression of CD95 antigen and Bcl-2 protein in non-Hodgkins lymphomas and Hodgkins disease. In: American Journal of ... Expression of CD95 antigen and Bcl-2 protein in non-Hodgkins lymphomas and Hodgkins disease. / Nguyen, Phuong L.; Harris, ... Nguyen, P. L., Harris, N. L., Ritz, J., & Robertson, M. J. (1996). Expression of CD95 antigen and Bcl-2 protein in non- ...
Histiocytosis: Practice Essentials, Pathophysiology, Epidemiology
16] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. [17] ... 35, 36, 37] However, although dendritic cells express CD95, CD95 ligation does not induce apoptosis. [38] ... Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med. 1993 Aug 1. 178(2):509-19. [QxMD MEDLINE Link]. [Full Text]. ... Dendritic cells express CD95, TRAIL-R2, and TRAIL-R3 in comparative levels. Similar to the role of CD95L, that of TRAIL- ...
Mouse Fas Ligand/TNFSF6 Biotinylated Antibody BAF526: R&D Systems
apoptosis (APO-1) antigen ligand 1; Apoptosis antigen ligand; APT1LG1CD95L; APTL; CD178 antigen; CD178; CD95L; CD95-L; Fas ... The specific receptor for FasL is Fas (CD95, Apo-1), a 45 kDa type I transmembrane protein that is a member of the TNF receptor ... antigen ligand; Fas ligand (TNF superfamily, member 6); Fas Ligand; FASLCD95 ligand; FASLG; TNFSF6; TNFSF6FasL; tumor necrosis ...
Fas receptor - Wikipedia
The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor ... Thus, the name Fas is derived from FS-7-associated surface antigen. The Fas receptor is a death receptor on the surface of ... Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region ... Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics. 14 ( ...
The role of APO-1-mediated apoptosis in the immune system - Krammer P. H.
Research products - EXBIO Antibodies
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression | bioRxiv
WHO EMRO | CD95 expression in white blood cells of malnourished infants during hospitalization and catch-up growth | Volume 15,...
Blood cells with receptors for the apoptotic marker CD95 (Fas antigen) can be identified in peripheral blood using flow ... تعبير الواسمة CD95 في الكريّات البيض لدى الرضَّع سيئي التغذية أثناء دخولهم المستشفى وخلال فتـرة النموّ التدارُكي ... CD95 expression in white blood cells of malnourished infants during hospitalization and catch-up growth ... CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after ...
The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma | Cancer...
The Fas/CD95 receptor regulates the death of autoreactive B cells and the selection of antigen-specific B cells ... FAS inactivation releases unconventional germinal center B cells that escape antigen control and drive IgE and autoantibody ... Tumor B cells from non-Hodgkins lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis ...
Glioblastoma Spreading Strategies Discovered
APG101 blocks the CD95 ligand and thereby prevents the activation of the CD95 signaling pathway, which leads to a reduction in ... Vaccinations and Antigens Medscape: Vaccinations are of course a part of immunotherapy. What is their status? ... By doing so, it blocks the signaling pathway between CD95 ligand and receptor. The interaction between the CD95 ligand and the ... Wick: APG101 is a protein that simulates the cell-death receptor CD95 and binds with a stable antibody fragment. ...
Imbalance between subpopulations of regulatory T cells in COPD | Thorax
B) Each subpopulation expressed different amounts of Foxp3, cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD31, HLA-DR, CD95 and ... CD4+ CD25+ regulatory T cells down- regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000;30:1538- ... cytotoxic T-lymphocyte antigen 4 (CTLA-4) and HLA-DR, and Ki-67, a nuclear protein expressed in proliferating cells (figure 1B ...
Code System Concept
Publication : USDA ARS
To date, it is clear that certain anti-human CD1b, CD14, CD18, CD44, CD45, CD47, CD49c, CD61, CD68, CD91, CD95, CD163 and ... Technical Abstract: The latest human lekocyte differentiation antigen (HLDA8) workshop included an Animal Homologues section. ... mw of antigen, and, if available, reaction with cloned swine gene product. ...
Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP...
Bone-marrow collected from BALB/c mice, or from iNOS-, CD95-, or CD95L-deficient mutants (and wild-type controls), was cultured ... Overall, PGE2 and isoproterenol shared a requirement for four effector elements (iNOS, CD95L, CD95, and terminal caspases), ... and the ligand for death receptor CD95 (CD95L). We examined the roles of iNOS, cAMP-mediated signaling, caspases, and CD95L/ ... CD95 in suppression of eosinopoiesis by PGE2 and other agents signaling through cAMP. ...
IMSEAR at SEARO: Search
CD4.sup.hi][CD8.sup.low] Double-Positive T Cells Are Associated with Graft Rejection in a Nonhuman Primate Model of Islet...
... antigen-dependent or antigen-independent cytokine production and lytic activity). Transplantation of islet cells into rhesus ... Figure 2(d) shows that most DP T cells in the peripheral blood, spleen, and liver expressed [CD28.sup.+][CD95.sup.+] (central ... 46] J. T. White, E. W. Cross, and R. M. Kedl, "Antigen-inexperienced memory [CD8.sup.+] T cells: where they come from and why ... reported that [CD4.sup.dim][CD8.sup.bright] T cells are an enriched antiviral subpopulation and recognize an antigen-specific ...
Melanoma; Malignant Melanoma
APC Mouse Anti-Human CD95
Cross linking of CD95 antigen on activated cells can elicit apoptosis. ... Cross linking of CD95 antigen on activated cells can elicit apoptosis. ... antigen (Fas/APO-1) that is a member of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily. It is associated ... antigen (Fas/APO-1) that is a member of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily. It is associated ...
Journal of Translational Medicine | Clinical translation
Tumors often lose expression of MHC molecules and/or antigens. However, NK cells can lyse tumor cells in a non-MHC-restricted ... RT upregulates cell death receptors such as Fas/CD95 and MHC-I... ... Tumor cells killed by radiation therapy (RT) are a potentially good source of antigens for dendritic cell (DC) uptake and ... With the growing use of prostate-specific antigen testing, the frequency of prostate cancer has progressively increased in ...
Carsten Watzl - Department of Immunology
Muller, M.; Scaffidi, C.; Galle, P. R.; Stremmel, W.; Krammer, P. H.: ¬The¬ role of p53 and the CD95 (APO-1/Fas) death system ... Tissue Antigens 2000: 240-247 (56). I am interested in this work. ... Scaffidi, C.; Schmitz, I.; Krammer, P. H.; Peter, M. E.: ¬The¬ role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol ... Medema, J. P.; Scaffidi, C.; Krammer, P. H.; Peter, M. E.: Bcl-xL acts downstream of caspase-8 activation by the CD95 death- ...
PRO Entry Report - PR:P25445
Faslg CLIA Kit for Mouse(Mus musculus) | EIAab.comFaslg CLIA Kit for Mouse(Mus musculus) | EIAab.com
DeCS Ingl s
CD178 Antigen .. CD95 Antigen Ligand .. CD95 Ligand .. CD95L .. Fas Ligand .. Fas Ligand (FasL) .. FasL Protein .. TNF ... Antigen, CD178 .. Antigens, CD178 .. CD178 Antigens .. Tumor Necrosis Factor Ligand Superfamily Member 6 .. 1.00. ... CD254 Antigen .. OPGL Protein .. Osteoclast Differentiation Factor .. Osteoprotegerin Ligand .. RANKL Protein .. Receptor ... Antigen, CD254 .. Differentiation Factor, Osteoclast .. Receptor Activator of Nuclear Factor kappa B Ligand .. Receptor ...
Histiocytosis: Practice Essentials, Pathophysiology, Epidemiology
16] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. [17] ... 35, 36, 37] However, although dendritic cells express CD95, CD95 ligation does not induce apoptosis. [38] ... Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med. 1993 Aug 1. 178(2):509-19. [QxMD MEDLINE Link]. [Full Text]. ... Dendritic cells express CD95, TRAIL-R2, and TRAIL-R3 in comparative levels. Similar to the role of CD95L, that of TRAIL- ...
Pediatric HIV Infection: Practice Essentials, Background, Pathophysiology
As the immune status deteriorates, an increase in CD95+ T cells is found; conversely, a low CD95+ T-cell count is found in ... Although infants possess numerous antigen-presenting and effector cells compared with adults, their cytokine production, ... The CD95/Fas receptor/ligand system is necessary for the apoptosis of T cells, and abnormalities in this system are linked with ... IIb/IIIa receptor by the HIV-GP 160/120 antigen. Decreased platelet production is common in HIV infection regardless of the ...
CD8A - What does CD8A stand for? The Free Dictionary
CD95. *CD95. *CD95. *CD95. *CD95 antigen. *CD95 antigen. *CD95 antigen. *CD95 antigen ... Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in ... Fluorochrome- or biotinlabeled human monoclonal antibodies specific for the following antigens were purchased from BD ... CD95 (DX2), CD1b (SN13), CD8[beta] (SIDI8BEE), HLA-DR (G46-6), CXCR5 (MU5UBEE), and PD-1 (EH12.2H7).. [CD4.sup.hi][CD8.sup.low ...
LigandCD95LAntibodiesSuperfamilyReceptorsSelf antigensLymphocytesFasLCD178TNFRSF6Differentiation antigenMouse Anti-Human CD95ExpressionProteinGlycoproteinSpecificityMonoclonal AntibodySurfaceCD40AntibodyRespective antigenRecombinantCellsCytokineLeukocyteApoptoticMoleculeMiceImmuneCD18PeripheralProapoptoticCD28Induces apoptosis
Ligand14
- In mice, eosinopoiesis is suppressed in vitro by prostaglandin E2 (PGE2) and in vivo by diethylcarbamazine, through a proapoptotic mechanism sequentially requiring inducible NO synthase (iNOS) and the ligand for death receptor CD95 (CD95L). (hindawi.com)
- It also requires CD95 ligand (CD95L, CD158) at a second critical step, downstream from iNOS [ 4 ], to suppress eosinopoiesis. (hindawi.com)
- Apoptosis can be induced through several death receptors belonging to the TNFR/nerve growth factor receptor superfamily: CD95 (APO-1/Fas) ( 1 , 2 ), TNFR1 ( 3 ), DR3/APO-3 ( 4 ), TNF-related apoptosis-inducing ligand receptor (TRAILR) 1/DR4/APO-2 ( 5 ), TRAILR2/DR5 ( 6 ), and DR6 ( 7 ). (aai.org)
- AICD is mediated predominantly by interaction of CD95 with its cognate ligand (CD95 ligand) ( 8 , 9 , 10 , 11 ). (aai.org)
- TCR-stimulated T cells express the CD95 ligand which triggers CD95 by clustering of the receptors. (aai.org)
- Upon binding of its ligand CD95L, CD95 interacts with adaptor proteins to form a death-inducing signaling complex to trigger a cell death signal. (bio-rad-antibodies.com)
- The strength of binding (affinity constant) between a receptor (e.g., one antigen-binding site on an antibody) and a ligand (e.g., epitope on an antigen). (roitt.com)
- The purified ligand is then released by disrupting the antibody-antigen interaction, for example by changing the pH. (roitt.com)
- CD178, also known as Fas ligand (FasL, Apo-1 Ligand, CD95 Ligand, TNFSF6) is a type-II transmembrane protein that is part of the tumor necrosis factor family (TNF). (eaglebio.com)
- This product recognizes the human CD178 cell surface antigen, a 40kDa glycoprotein also known as Fas ligand (CD95L). (raybiotech.com)
- Key players in the controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR activated by its cognate ligand CD95L triggering programmed cell death. (researchgate.net)
- The cell surface protein Fas (CD95) and its ligand play a pivotal role in regulating lymphocyte apoptosis, and defective expression of either Fas or Fas ligand results in marked overaccumulation of mature lymphocytes and autoimmune disease in mice. (medscape.com)
- T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). (embl.de)
- Among these death receptors, Fas/CD95 and its specific ligand FasL/CD95L were demonstrated to be of importance, and it was shown that stimulation of RASFs with FasL initiates proapoptotic signals [ 8 , 9 ]. (biomedcentral.com)
CD95L5
- We examined the roles of iNOS, cAMP-mediated signaling, caspases, and CD95L/CD95 in suppression of eosinopoiesis by PGE2 and other agents signaling through cAMP. (hindawi.com)
- Overall, PGE2 and isoproterenol shared a requirement for four effector elements (iNOS, CD95L, CD95, and terminal caspases), which together define a pathway targeted by several soluble up- and downmodulators of eosinopoiesis, including drugs, mediators of inflammation, and cytokines. (hindawi.com)
- 4) Lastly, a positive correlation was seen between cytotoxic molecules and CD45RO memory marker in CD4⁺ T cells and between caspase-3 and CD95L within CD4⁺ CD95⁺ T cells. (fiocruz.br)
- CD95/CD95L interactions play an important role in the maintenance of peripheral tolerance and survival. (biolegend.com)
- As a consequence, alterations in the CD95/CD95L pathway have been involved in several disease co. (researchgate.net)
Antibodies9
- Present on a minority of resting blood lymphocytes, CD95 expression is upregulated on activated T and B lymphocytes and natural killer cells, where binding of the antigen by anti-Fas and anti-APO-1 antibodies has been shown to induce apoptosis. (elsevier.com)
- However, the use of monospecific CD95 antibodies is associated with significant off-target toxicity. (baliopharm.ch)
- This can be achieved by using bispecific antibodies recognizing CD20 and inducing CD95 apoptosis only after initial interaction with the target antigen. (baliopharm.ch)
- The bispecific antibody for the first in vitro and in vivo studies was produced by chemical hybridization of fragmental parental CD20 and CD95 antibodies. (baliopharm.ch)
- In in vitro studies, CD20xCD95 bispecific antibodies have been shown to selectively trigger the CD95 death receptor and kill CD20 positive SKW lymphoma cells. (baliopharm.ch)
- 2. Construction of optimized bispecific antibodies for selective activation of the death receptor CD95. (baliopharm.ch)
- Such antibodies, which can be produced either by chemical cross-linkage or by recombinant DNA techniques, can be used to link together two different antigens or cells (e.g., a cytotoxic T-cell and a tumor cell). (roitt.com)
- The ability to produce antibodies against nonself antigens while "tolerating" (not producing antibodies against) self-antigens. (mheducation.com)
- Refers to the type of specific immunity that develops after exposure to a suitable antigen or is produced after antibodies are transferred from one individual to another. (mheducation.com)
Superfamily8
- CD95 (APO-1/Fas) is a member of the superfamily that includes the nerve growth factor and tumor necrosis factor receptors, OX40, CD27, CD30, and CD40. (elsevier.com)
- The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene. (wikipedia.org)
- The CD95 recognizes a 48-kdalton (kDa) antigen (Fas/APO-1) that is a member of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily. (bdbiosciences.com)
- Expression of APO-1 (CD95), a member of the NFG/TNF superfamily, in normal and neoplastic colon epithelium. (bdbiosciences.com)
- Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. (bdbiosciences.com)
- CD178 binds to CD95, a member of the TNFR superfamily, to induce apoptosis. (biolegend.com)
- Clone JD3 recognizes the human DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). (miltenyibiotec.com)
- CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. (abcam.cn)
Receptors4
- CD95 apoptosis sensitivity requires formation of a functional receptor associated death-inducing signaling complex (DISC), i.e., a protein complex of CD95 receptors, the adaptor Fas-associated death domain protein (FADD)/MORT1 and caspase-8 (FADD-like IL-1β-converting enzyme (FLICE), MACH, Mch5). (aai.org)
- T cell receptors can recognize antigen fragments bound to the major histocompatibility complex on the surface of an antigen-presenting cell. (scopeheal.com)
- The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD40. (deathbase.org)
- Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. (abeomics.com)
Self antigens2
- The immune system does not normally respond to self antigens. (bmj.com)
- To this end, we quantified Fas and FasL induction by different stimuli and analyzed the effects of Fas/FasL deficiency during a protective immune response and after exposure to self-antigens. (figshare.com)
Lymphocytes11
- Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)
- The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (scopeheal.com)
- Effective induction of antigen-specific T cell responses requires interaction between dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (scopeheal.com)
- Although circulating T-cell lymphocytes can recognize antigens independently, their number is small. (scopeheal.com)
- The first signal may involve the interaction between a major histocompatibility complex peptide complex I and major histocompatibility complex II in an antigen-presenting cell with the T-cell receptor (RCT) on effector lymphocytes. (scopeheal.com)
- MyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8(+) T lymphocytes. (harvard.edu)
- The phenotypic features acquired subsequent to antigen-specific stimulation in vitro were evaluated by means of the kinetic expressions of CD69 and CD25 activation molecules on T lymphocytes and assayed by flow cytometry in response to PPD, Ag85B, and ferritin in PPD-positive healthy control individuals. (hotelelpinchedeoro.com)
- Immunity mediated by lymphocytes and characterized by antigen specificity and memory. (roitt.com)
- Lymphocytes learn to react with antigens during lymphopoiesis in central lymphoid organs, thymus, and bone marrow. (bmj.com)
- A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. (rush.edu)
- DR3 is expressed preferentially by activated and antigen-experienced T lymphocytes. (miltenyibiotec.com)
FasL2
- CD3 + TCR-αβ + CD4 - CD8 - ) T cells that have been proposed to derive from CD8 + cells, we decided to explore the role of Fas and FasL in self-antigen-induced CD8 downregulation. (figshare.com)
- Our data describes how Fas and FasL upregulation differs depending on the setting of CD8 T cell activation and demonstrates that Fas/FasL signaling maintains CD8 expression during repetitive antigen stimulation and following self-antigen encounter. (figshare.com)
CD1781
- Binding of CD178 to Fas (CD95) results in the induction of apoptosis. (raybiotech.com)
TNFRSF62
- TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. (eiaab.com)
- Mouse anti Human CD95 antibody, clone C02-6C8, recognizes CD95, also known as TNFRSF6, Apo-1 antigen, apoptosis-mediating surface antigen FAS and FASLG receptor. (bio-rad-antibodies.com)
Differentiation antigen2
- The latest human lekocyte differentiation antigen (HLDA8) workshop included an Animal Homologues section. (usda.gov)
- The breast differentiation antigen NY-BR-1, expressed specifically in normal and malignant breast tissue, has also immunogenic properties. (biomedcentral.com)
Mouse Anti-Human CD952
- Sandwich ELISA analysis of human CD95 using Mouse anti Human CD95 ( MCA6272GA ) as a capture reagent and biotinylated Mouse anti Human CD95 ( MCA6273B ) as a detection reagent with purified recombinant CD95 as the antigen. (bio-rad-antibodies.com)
- The biotinylated Mouse anti Human CD95 antibody, clone C02-6C8 (MCA6273B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD95 antibody, clone E06-1A9 ( MCA6272GA ) as the capture antibody. (bio-rad-antibodies.com)
Expression11
- This CD95-mediated apoptosis is at least partially inhibited by expression of the Bcl-2 protooncogene. (elsevier.com)
- To evaluate possible roles of CD95 and Bcl-2 in growth regulation of lymphoid neoplasms, we studied by immunohistochemistry the expression of CD95 and Bcl-2 in 67 B- and 5 T-cell lympbomas, and 10 cases of Hodgkin's disease. (elsevier.com)
- The infrequent expression of CD95 in high-grade B-cell lymphomas suggests an association between loss ofCD95 expression/function and a more aggressive tumor grade. (elsevier.com)
- 80 of the mAb proved to be + on pig cells and are now being analyzed in more depth by confirming appropriate tissue and cell subset expression, effect of activation on expression, mw of antigen, and, if available, reaction with cloned swine gene product. (usda.gov)
- Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): A possible mechanism for lymphopenia. (bdbiosciences.com)
- Differential expression of apoptosisrelated Fas antigen on lymphocyte subpopulations in human peripheral blood. (bdbiosciences.com)
- In the present study, we have analyzed the relative frequency of MAITs and the expression of the cell surface antigens in MAITs to seek a possible link to the disease. (springeropen.com)
- While the expression of CCR5, CCR6, CD95, CD127, and CD150 has increased in untreated subjects compared with that in HDs, CD45RO has declined in untreated subjects in both DN MAITs and CD8 hi MAITs. (springeropen.com)
- Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine. (harvard.edu)
- Using high-pressure antigen retrieval and tyramide signal amplification, we find moderately high levels of CD16 expression in the parenchyma of normal brains which is not normally observed using standard avidin/biotin complex (ABC) techniques. (ox.ac.uk)
- It is also obvious that high expression of the CAR can result in antigen-independent CAR signaling, resulting in T cell exhaustion and sub-optimal anti-tumor responses, or lead to the inappropriate acknowledgement of tumor antigen on self-tissue [1, 2]. (syncom.org)
Protein1
- Fas antigen is a cell-surface protein that mediates apoptosis. (deathbase.org)
Glycoprotein1
- CD133 antigen , also known as prominin-1 , is a glycoprotein that in humans is encoded by the PROM1 gene . (wikidoc.org)
Specificity1
- A KIR receptor that has specificity for HLA-C ANTIGENS. (wakehealth.edu)
Monoclonal Antibody1
- Mouse anti-Fas monoclonal antibody has a cytolytic activity on human cells that express the antigen. (deathbase.org)
Surface6
- Thus, the name Fas is derived from FS-7-associated surface antigen. (wikipedia.org)
- The antigen-presenting cell surface contains two peptide-binding proteins: that is, major histocompatibility complex (MHC) classes I and II. (scopeheal.com)
- The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. (deathbase.org)
- Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells. (deathbase.org)
- Furthermore, resting CD4 + T cells from mutant A(β)(k) transgenic mice expressed higher levels of cell surface CD95 (Fas, APO-1). (utmb.edu)
- A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery. (ontobee.org)
CD401
- The bispecific concept is also applicable to a variety of different target antigens, such as CD19, CD40, tenascin and NG2 and is protected by a granted patent. (baliopharm.ch)
Antibody15
- Murine WR19L cells or L929 cells transformed with the human Fas antigen cDNA were killed by the anti-Fas antibody in the process known as apoptosis. (deathbase.org)
- Novotarg is Baliopharm`s lead bispecific antibody targeting CD20 and CD95. (baliopharm.ch)
- CD20 is an established target antigen for antibody-based immunotherapy in cancer (like lymphoma) and B-cell mediated autoimmune disease. (baliopharm.ch)
- In contrast, cell culture experiments have shown that the bispecific antibody exhibits no toxicity towards cultured CD95 sensitive cell lines, including normal human hepatocytes. (baliopharm.ch)
- 1. A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cells. (baliopharm.ch)
- 3. Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments. (baliopharm.ch)
- The use of immobilized antibody (or antigen) to select specific antigen (or antibody) from a mixture. (roitt.com)
- The binding strength between two molecules (e.g., antibody and antigen) taking into account the valency of the interaction. (roitt.com)
- An artificially produced hybrid antibody in which each of the two antigen-binding arms is specific for a different antigenic epitope. (roitt.com)
- they are self-renewing, and frequently secrete high levels of antibody, which binds to a range of antigens ("polyspecificity") with a relatively low affinity. (roitt.com)
- cells have been found to regulate early and not late GC reactions to control antigen-specific antibody and B cell memory space (18, 25). (medlibraryalert.com)
- Multimeric display of the antigen combined with potent adjuvant can enhance the potency and longevity of the antibody response. (emory.edu)
- The trimeric form induces higher neutralizing antibody titer compared to monomer with as low as 1μg antigen dose. (emory.edu)
- had been the first ever to describe the immediate immunofluorescence technique using an antibody mounted on a fluorescent dye, fluorescein isocyanate, to localize it is respective antigen inside a freezing cells section (3, 4). (icrs-world-congress.org)
- thus HA may be the immunodominant antigen for the induction of antibody replies [6]. (cancer-basics.com)
Respective antigen1
- However, throughout their development, B cells are selected depending on their binding capacity to the respective antigen at several B-cell selection checkpoints. (nature.com)
Recombinant1
- Clinical and parasitological protection in a Leishmania infantum-macaque model vaccinated with adenovirus and the recombinant A2 antigen. (harvard.edu)
Cells27
- As an extension of the observation that mast cells undergo apoptosis following growth factor deprivation, we hypothesized that mast cells might also undergo apoptosis in response to activation through Fas Ag (CD95, APO-1), thus providing an additional pathway that could contribute to the regulation of mast cell numbers. (unibas.ch)
- In addition to the well-described on-target CTL anti-tumor cytotoxicity, Fas has been ascribed with a distinct function - the induction of bystander tumor cell death even amongst cognate antigen non-expressing (bystander) cells. (wikipedia.org)
- CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
- The CD95, clone DX2, is derived from hybridization of mouse Sp2/0 myeloma cells with spleen cells from C3H/He mice immunized with L cells transfected with CD95 antigen. (bdbiosciences.com)
- Cross linking of CD95 antigen on activated cells can elicit apoptosis. (bdbiosciences.com)
- Cancer-testis antigens (CTA) comprise a family of proteins, which are physiologically expressed in adult human tissues solely in testicular germ cells and occasionally placenta. (biomedcentral.com)
- Cancer testis antigens (CTAs) comprise an expanding family of proteins which are normally expressed in human testicular germ cells or placental trophoblast, but not in any other normal tissue. (biomedcentral.com)
- This model represents the main features of T cell reactivity: freshly isolated PHA-activated T cells cultured in IL-2 for a prolonged period of time develop a CD95 (APO-1/Fas) apoptosis-sensitive phenotype. (aai.org)
- Compromised stem cells can mature into antigen-processing cells, and some possess phagocytic capabilities. (scopeheal.com)
- They are committed to generating dendritic cells, "professional" antigen-presenting cells (APCs). (scopeheal.com)
- These cells can capture the antigen and migrate to the lymphoid organs, where they present the antigens to naïve T cells. (scopeheal.com)
- Contrary to conventional T cells, MAITs recognize vitamin B2 metabolites as antigens and promptly produce a plethora of cytokines and chemokines upon activation (Birkinshaw et al. (springeropen.com)
- The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus. (deathbase.org)
- Therefore, CD95 mediated apoptosis should be induced only in cells expressing CD20. (baliopharm.ch)
- Antigen (or autoantigen) engages a B cell receptor directly and also is endocytosed by an antigen presenting cell (typically a dendritic cell, but B cells also serve), in which intracellular degradation generates antigenic peptides. (bmj.com)
- DR3 is activated by TNFSF15, which is rapidly upregulated in antigen-presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation. (miltenyibiotec.com)
- Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production. (southernbiotech.com)
- Ab-mediated cross-linking of CD95 further increased apoptosis in CD4 + T cells from mutant A(β)(k) transgenic mice, but not from wild-type mice, suggesting apoptosis involved CD95 signaling. (utmb.edu)
- Cytotoxic T lymphocyte-associated antigen (CTLA)-4 (CD152), for example, which is essential for the in vivo suppressive activity of CD4 + CD25 + T cells, was constitutively expressed, and remained strongly upregulated after stimulation. (rupress.org)
- The cells were nonproliferative to stimulation via their T cell receptor for antigen, but the anergic state was partially reversed by interleukin (IL)-2 and IL-15. (rupress.org)
- Memory T cells are either CD4 + or the virus-specific CD8 + depending on the type of antigen encountered (MacLeod et al. (kallade-fin.com)
- In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. (ox.ac.uk)
- Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. (vanderbilt.edu)
- Diverse HVS transformed CBL lines in complete volumes of 50 l of Jurkat T cells induced for apoptosis with mouse anti CD95 Fas IgM served as favourable controls. (achr-signal.com)
- Jurkat T cells had been incubated with mouse anti CD95 Fas IgM and subjected to annexin V PI staining, FACS evaluation served as being a constructive management. (achr-signal.com)
- They recognize peptide-loaded major histocompatibility complexes (pMHCs), that are displayed by antigen presenting cells (APCs). (abeomics.com)
- Autoimmune myocarditis develops after the presentation of heart-specific antigens to autoaggressive CD4 + T cells and after inflammation has infiltrated the tissues. (biomedcentral.com)
Cytokine1
- T cell antigen gp39 (CD40L), a cytokine which seems to be important in B-cell development and activation. (embl.de)
Leukocyte1
- Pharmacogenetics studies have found an association between susceptibility to recurrent EM in response to several stimuli and human leukocyte antigen (HLA) haplotypes of class II, in particular HLA DQB1*0301 [ 23 ]. (biomedcentral.com)
Apoptotic1
- Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. (bdbiosciences.com)
Molecule2
- This enables the adaptor molecule Fas-associated death domain (FADD)/MORT1 ( 12 , 13 ) and the zymogen of caspase-8 (FADD-like IL-1β-converting enzyme (FLICE), MACH, Mch5) ( 14 , 15 , 16 ) to bind to CD95 via homophilic death domain and death effector domain (DED) interactions, respectively. (aai.org)
- The nucleotide sequence of the cDNAs revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide (Mr 36,000) with a single transmembrane domain. (deathbase.org)
Mice2
- Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. (deathbase.org)
- Mice carrying the lymphoproliferation (lpr) mutation have defects in the Fas antigen gene. (deathbase.org)
Immune2
- Specifically NY-ESO-1 is able to elicit combined humoral and cell mediated immune response and considered to be the most immunogenic of the above antigens. (biomedcentral.com)
- Any substance that nonspecifically enhances the immune response to antigen. (roitt.com)
CD183
- Antigens, CD18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- This graph shows the total number of publications written about "Antigens, CD18" by people in UAMS Profiles by year, and whether "Antigens, CD18" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Antigens, CD18" by people in Profiles over the past ten years. (uams.edu)
Peripheral1
- 04). Two of three peripheral T-cell lymphomas - including one anaplastic large cell lymphoma-expressed CD95. (elsevier.com)
Proapoptotic1
- Microglial turnover was assessed using terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) (DNA damage), BAX (proapoptotic marker), Fas (CD95) (proapoptotic), proliferating cell nuclear antigen (PCNA) (proliferation and DNA repair), Ki-67 (cell proliferation) and BCL-2 (antiapoptosis). (ox.ac.uk)
CD281
- Engagement of CD80/86 on the antigen presenting cell with CD28 on the T cell delivers a costimulatory signal necessary for activation. (bmj.com)
Induces apoptosis1
- CD95, also called "death receptor" induces apoptosis. (baliopharm.ch)