Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Cystic Fibrosis Transmembrane Conductance Regulator: A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Sweat: The fluid excreted by the SWEAT GLANDS. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Hair Cells, Auditory, Outer: Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.Hair Cells, Auditory: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Cochlea: The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.Hearing: The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition.Hair: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.Cochlear Microphonic Potentials: The electric response of the cochlear hair cells to acoustic stimulation.Hair Cells, Auditory, Inner: Auditory sensory cells of organ of Corti, usually placed in one row medially to the core of spongy bone (the modiolus). Inner hair cells are in fewer numbers than the OUTER AUDITORY HAIR CELLS, and their STEREOCILIA are approximately twice as thick as those of the outer hair cells.Hair Cells, Vestibular: Sensory cells in the acoustic maculae with their apical STEREOCILIA embedded in a gelatinous OTOLITHIC MEMBRANE. These hair cells are stimulated by the movement of otolithic membrane, and impulses are transmitted via the VESTIBULAR NERVE to the BRAIN STEM. Hair cells in the saccule and those in the utricle sense linear acceleration in vertical and horizontal directions, respectively.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Hyalin: A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.Adenoma: A benign epithelial tumor with a glandular organization.Sweat Gland NeoplasmsAdenoma, Liver Cell: A benign epithelial tumor of the LIVER.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Chemotactic Factors: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.Sperm Motility: Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.N-Formylmethionine: Effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.Chemotaxis, Leukocyte: The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Gastrointestinal Motility: The motor activity of the GASTROINTESTINAL TRACT.Chemotaxis: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.

CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5. (1/315)

The CD9 molecule is a 24-27 kDa cell surface glycoprotein, which may be related to Schwann cell migration and adhesion. In this study, we examined the expression of CD9 in human extravillous trophoblasts, which invade into the endometrium during implantation and placentation. CD9 was detected immunohistochemically on the extravillous trophoblasts in the cell columns of first trimester placentae, but not on villous trophoblasts. In the second and third trimester, CD9 was highly expressed on the extravillous trophoblasts in the basal plate of placentae, and in the chorion laeve in the fetal membrane of term placentae. The molecular mass of CD9 in the chorion laeve was shown to be 27 kDa by Western blotting. The mRNA of CD9 was also detected in the chorion laeve by reverse transcription-polymerase chain reaction (RT-PCR). Proteins were purified from chorion laeve by affinity chromatography with anti-integrin alpha3 and alpha5 monoclonal antibodies and Western blotting, revealed that CD9 was associated with both integrins. These findings indicate that CD9 is a differentiation-related molecule present in the extravillous trophoblasts. Since it is associated with integrin alpha5 which has been proposed to regulate trophoblast invasion, CD9 may be implicated in trophoblast invasion at the feto-maternal interface.  (+info)

CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. (2/315)

The CD9 molecule is expressed on human extravillous trophoblasts, which invade the endometrium during implantation and placentation. To elucidate the role of CD9 in trophoblastic function, we investigated the expression of CD9 protein and mRNA in BeWo cells, a human trophoblast-like choriocarcinoma cell line, using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). When BeWo cells were cultured with anti-CD9 monoclonal antibodies (mAb), their invasion through the extracellular matrices was significantly enhanced in a dose-dependent manner. Cell proliferation and human chorionic gonadotrophin production were unaffected. On the other hand, culture in the presence of mAb against integrins alpha3, alpha5 and beta1, which partially block the interaction with the extracellular matrices, inhibited BeWo cell invasion. Anti-CD9 monoclonal antibody had a stimulatory effect on BeWo cell invasion in the presence of anti-integrin alpha3 antibody. In contrast, it had no effect in the presence of mAb against integrins alpha5 and beta1, which were also highly expressed on BeWo cells. These findings suggest that CD9 has a function connected with the invasive properties of BeWo cells, which is partially mediated by integrin alpha5beta1. This may relate to the involvement of CD9 in trophoblastic invasion.  (+info)

Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. (3/315)

Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. The suppression of cell motility by MRP-1/CD9 may cause suppression of the metastasis. As we could not find any reports concerning the expression of MRP-1/CD9 and KAI1/CD82 in oesophageal cancers we investigated their expression in oesophageal specimens. We conducted immunohistochemical staining for MRP1/CD9 against 108 cases of oesophageal squamous cell carcinoma using anti-MRP-1/CD9 monoclonal antibody M31-15, and for KAI1/CD82 against 104 cases using anti-KAI1/CD82 monoclonal antibody C33. To investigate the gradual expression of MRP-1/CD9 and KAI1/CD82, 24 oesophageal dysplasias were immunohistochemically stained using the same method and then investigated. The expression of both MRP-1/CD9 and KAI1/CD82 were positive on the cell membranes of normal oesophageal epithelial cells, but reduced or negative in the cancer cells. Reduced MRP-1/CD9 expressions significantly correlated to tumour depth (P = 0.0009). We found a significantly greater number of reduced or negative expression of MRP-1/CD9 and KAI1/CD82 in lymph node metastatic cases (P = 0.0003 and P= 0.0129, respectively), but not in distant metastatic cases. The 5-year survival rate of MRP-1/CD9-negative and reduced patients was significantly worse than those of positive patients (n = 108, curative cases, RO). Few cases remained KAI1/CD82-positive (9.6%; 10/104) in oesophageal cancer. Twenty (83.3%) and twenty-two (91.7%) cases out of 24 dysplasias were defined as KAI1/CD82-positive and MRP1/CD9-positive, respectively. The decrease in MRP-1/CD9 and KAI1/CD82 expression may facilitate lymph node metastasis in oesophageal squamous cell carcinomas. Knowing the status of the expression of MRP-1/CD9 appears helpful in predicting the prognosis for each patient.  (+info)

Stromal cell CD9 regulates differentiation of hematopoietic stem/progenitor cells. (4/315)

CD9 belongs to the transmembrane 4 superfamily, and has been shown to influence cell proliferation, motility, and adhesion. We show here that ligation of CD9 modifies proliferation and/or differentiation of hematopoietic stem/progenitors. Pluripotent EML-C1 hematopoietic cells were cocultured with MS-5 stromal cells in the presence of KMC8.8, an anti-CD9 antibody. Numbers of recovered EML-C1 cells were slightly reduced and the antibody caused the hematopoietic cells to migrate beneath the adherent stromal cell layer. Of particular interest, EML-C1 cells recovered from CD9-ligated cultures had undifferentiated properties. Separate pretreatment of the two cell types with antibody showed that stromal-cell CD9 mediated these responses. Spontaneous expression of erythroid marker was completely blocked and there was a shift towards undifferentiated clonogenic progenitors. Immunoprecipitation studies showed that stromal-cell CD9 associates with the beta1 subunit of integrin, as well as a novel 100 kD protein. Antibody cross-linking of cell surface CD9 increased the amount of 100 kD protein that was subsequently coprecipitated with CD9. These observations show that stromal-cell CD9 influences physical interactions with hematopoietic cells and may be one factor that determines the degree of stem cell differentiation.  (+info)

Apoptosis of erythroid precursors under stimulation with thrombopoietin: contribution to megakaryocytic lineage choice. (5/315)

Although the effect of thrombopoietin (TPO) on megakaryocyte production is well established, its role in the commitment of multipotential hematopoietic progenitors to the megakaryocytic lineage remains to be determined. In the present study, we attempted to clarify the determination process of megakaryocytic lineage as a terminal differentiation pathway under stimulation with TPO. Day 7 cultured cells grown by TPO derived from cord blood CD34+ cells were divided into four subpopulations on the basis of CD34 and CD41 expression. The CD34-/CD41- cells showed the labeling pattern of anti-CD42b and anti-CD9 antibodies closer to that of the CD34+/CD41- cells than the CD34+/CD41+ cells. Replating experiments revealed that approximately 40% of the CD34-/CD41- cells proliferated in response to a combination of growth factors, and more than 80% of them were pure erythroid precursors. However, this subpopulation failed to grow/survive and fell into apoptosis in the presence of TPO alone. In contrast, the CD34+/CD41+ cells, which predominantly contained megakaryocytic precursors, exerted a low but significant proliferative potential in the presence of TPO. The insufficient response to TPO of the CD34-/CD41- cells may result from the apparently low expression of c-MpI, as determined by flow cytometric analysis and reverse transcription-polymerase chain reaction analysis. Therefore, these results suggest that the apoptosis of hematopoietic precursors other than megakaryocytic precursors is related to the determination of the terminal differentiation under the influence of TPO.  (+info)

CD9 is expressed on the cell surface of human granulosa cells and associated with integrin alpha6beta1. (6/315)

The CD9 molecule is a 24-27 kDa cell surface glycoprotein which is reported to be involved in cell adhesion and migration. Recently, CD9 was shown to be associated with beta1-related integrins. We have previously found that integrin alpha6beta1 is expressed on human granulosa cells (GC) and regulates luteinization of GC in concert with its ligand laminin. In this study, we examined the expression of CD9 in human ovary and the relationship between CD9 and integrin alpha6beta1 in GC. By immunohistochemistry, CD9 was detected on GC in a small antral follicle of <1 mm in diameter. In growing follicles, CD9 was moderately expressed on both GC and theca interna cells (TI). The expression intensity of CD9 on GC increased in preovulatory follicles. In the early luteal phase, CD9 was expressed in both luteinizing GC and TI. The expression intensity on large luteal cells decreased in the mid-luteal phase. In the corpus luteum (CL) of pregnancy, CD9 continued to be expressed on large luteal cells, but not on small luteal cells. By flow cytometry, CD9 was detected on the cell surface in approximately 90% of the isolated GC from patients undergoing in vitro fertilization. The molecular weight of CD9 in the isolated GC was shown to be 26.5 kDa by Western blotting. CD9 mRNA was also detected in the isolated GC and CL by reverse transcription-polymerase chain reaction (RT-PCR). The proteins purified from GC by immunoaffinity chromatography using anti-integrin alpha6 monoclonal antibodies were shown by Western blotting to include CD9 as well as integrin beta1. These findings suggest that CD9 is a differentiation-related molecule of GC and TI and that it is associated with integrin alpha6beta1 on the cell surface of GC, suggesting that CD9 is implicated in the function of human GC in cooperation with integrin alpha6beta1.  (+info)

A novel molecular staging protocol for non-small cell lung cancer. (7/315)

A molecular staging protocol using reliable markers is of importance in predicting the prognosis of patients with non-small cell lung cancer (NSCLC) and for instituting their appropriate post-surgical treatment. We analysed tumor tissues from 187 NSCLC patients. The DNA and mRNA were extracted from frozen specimens, and then polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct sequencing were performed to investigate mutations of p53 from exons 5-8, and mutations of K-ras at exon 1. To determine MRP-1/CD9 gene and KA11/CD82 gene expression, which have been postulated to be metastasis suppressor genes, we have applied quantitative RT-PCR. A Cox multivariate regression analysis showed that nodal status, MRP-1/CD9 and K-ras status were significant factors for prognosis (P<0.0001, P=0.0083 and P=0.0004, respectively). Based on these results, we classified the patients into three groups according to their MRP-1/ CD9 and K-ras status. Patients with both MRP-1/CD9 positive and wild K-ras tumors were defined as group A, patients with either reduced MRP-1/CD9 or mutant K-ras tumors were defined as group B and patients with both reduced MRP-1/CD9 and mutant K-ras tumors were designated as group C. This new classification was significantly correlated with the tumor status and pathological stage (P=0.0098 and P=0.0017, respectively). The overall survival rate of the group A patients was significantly better than the group B patients (59.6% vs 27.9%, P=0.0001) and also that of group B patients was better than the group C patients (27.9% vs 20.0%, P=0.0378). This tendency was also found in patients with 110 node-negative NSCLCs (A vs B vs C=75.8% vs 34.9% vs 0.0%, P<0.0001). A Cox multivariate regression analysis in NSCLC patients demonstrated that an evaluation for both MRP-1/CD9 expression and K-ras mutations had a significant prognostic effect as well as nodal status (P<0.0001).  (+info)

Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. (8/315)

Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and expressing CD82 or CD9 by cDNA transfection. Only CD82- or CD9-expressing cells grown in Gal-supplemented medium showed reduced motility and massive cell death, which are characteristic of apoptosis, after a latent period. Under this condition, endogenous GM3 synthesis was observed as a common factor, and N-glycosylation occurred at a high level in CD82 and to a lesser extent in CD9. Thus, the malignancy-suppressing effect of CD82 or CD9 is based partially on cell motility inhibition and apoptosis induction promoted by concurrent GM3 synthesis and N-glycosylation.  (+info)

*CD9

... antigen is a protein that in humans is encoded by the CD9 gene. The protein encoded by this gene is a member of the ... CD9 CD9 molecule". Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C (2000). "Severely Reduced Female Fertility in CD9- ... Boucheix C, Benoit P, Frachet P, Billard M, Worthington RE, Gagnon J, Uzan G (1991). "Molecular cloning of the CD9 antigen. A ... Higashihara M, Takahata K, Yatomi Y, Nakahara K, Kurokawa K (1990). "Purification and partial characterization of CD9 antigen ...

*CD49c

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2 ... Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (February 1999). "CD9 is expressed in ... CD49c antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA3 Info with links in the Cell ... "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". Park KR, Inoue T, Ueda M, Hirano T, ...

*TSPAN4

This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known ... TSPAN4 has been shown to interact with CD9, ITGA6, CD29, CD49c and CD81. GRCh38: Ensembl release 89: ENSG00000214063 - Ensembl ...

*CD82 (gene)

1992). "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium ... 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". J. Biol. Chem. 273 (46): 30537-43. doi: ... 2000). "Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin- ... 1991). "A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23". ...

*CD63

1991). "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in ... Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta ... CD63 antigen is a protein that in humans is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular ... Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and ...

*CD37

"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of ... Horejsí V, Vlcek C (August 1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, ... Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene. The protein encoded by this gene is a member of ... Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/ ...

*CD19

Mouse CD Antigen Chart Human CD Antigen Chart Human CD19 genome location and CD19 gene details page in the UCSC Genome Browser ... "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537 ... yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. The CD19 gene encodes ... B-lymphocyte antigen CD19, also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the ...

*PSG1 (gene)

These genes belong to a specific gene family; they are a subgroup of the carcinoembryonic antigen (CEA) family of genes. CEAs ... Waterhouse R, Ha C, Dveksler GS (January 2002). "Murine CD9 is the receptor for pregnancy-specific glycoprotein 17". J. Exp. ... Khan WN, Hammarström S (1989). "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS beta G/FL-NCA ... Khan WN, Osterman A, Hammarström S (May 1989). "Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related ...

*CD29

... Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human ITGB1 genome location and ITGB1 gene ... CD29 has been shown to interact with ACTN1; CD46, CD9, FHL2, Filamin, FLNB, CD81, GNB2L1, ITGB1BP1, LGALS8, MAP4K4, NME1, PKC ... CD29 is an integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ...

*Heat shock protein 47

Hattori T, Takahash K, Yutani Y, Fujisawa T, Nakanishi T, Takigawa M (2001). "Rheumatoid arthritis-related antigen 47kDa (RA- ... "Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines". Journal of Cellular ... "Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8 ...

*IGSF2

Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily ... Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439-48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317. Soares ...

*CD81

Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E (Apr 2001). "The major CD9 and CD81 ... 1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... CD81 has been shown to interact with TSPAN4, CD19, CD9, PTGFRN, CD117 and CD29. Benzyl salicylate and terfenadine have been ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ...

*Marginal zone B-cell

The MZ B cells within this region typically express high levels of IgM, CD21, CD1, CD9 with low to negligible levels of ... The MZ B cells are especially well positioned as a first line of defense against systemic blood-borne antigens that enter the ... It is believed they are especially reactive to bacterial cell wall components and self-antigens which are the products of aging ...

*Stem cell marker

CK19, Cytokeratin 19, K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT ... Kanatsu-Shinohara M, Toyokuni S, Shinohara T (January 2004). "CD9 is a surface marker on mouse and rat male germline stem cells ... May 2006). "Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell ... Muramatsu T, Muramatsu H (2004). "Carbohydrate antigens expressed on stem cells and early embryonic cells". Glycoconjugate ...

*CD53

1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". ... 1998). "Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human ... Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. The protein encoded by this gene is a ... A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322-5. PMID 2258620. Dianzani U, ...

*CD151

Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E (2001). "The major CD9 and CD81 ... Raph blood group system in the BGMUT blood group antigen gene mutation database Human CD151 genome location and CD151 gene ... comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515-25. doi:10.1177/002215549704500404. ... identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263-70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID ...

*CD47

... was first identified as a tumor antigen on human ovarian cancer in the 1980s. Since then, CD47 has been found to be ... Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX ... 1994). "Rh-related antigen CD47 is the signal-transducer integrin-associated protein". J. Biol. Chem. 269 (3): 1567-70. PMID ... Brown E, Hooper L, Ho T, Gresham H (1991). "Integrin-associated protein: a 50-kD plasma membrane antigen physically and ...

*Complement receptor 2

... because CR2 binds to antigens through attached C3d (or iC3b or C3dg) when the membrane IgM binds to the antigen. This results ... "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". J. Biol. Chem. 273 (46): 30537-43. doi:10.1074/jbc. ... in the B cell having greatly enhanced response to the antigen. Complement receptor 2 has been shown to interact with CD19. ...

*CD59

1990). "The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility". Eur. J. Immunol ... It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex. Mutations affecting GPI ... CD59 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD59 genome location and CD59 gene ... 1990). "Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes". DNA Cell Biol. 9 (3): 213 ...

*CD46

... has been shown to interact with CD9, CD151 and CD29. GRCh38: Ensembl release 89: ENSG00000117335 - Ensembl, May 2017 ... NIH/UW entry on Atypical Hemolytic-Uremic Syndrome OMIM entries on Atypical Hemolytic-Uremic Syndrome CD46 antigen at the US ...

*ITGA7

Kaufman, SJ; Foster, RF; Haye, KR; Faiman, LE (June 1985). "Expression of a developmentally regulated antigen on the surface of ... Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and ...

*CD117

... has been shown to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, ... Ashman LK, Cambareri AC, To LB, Levinsky RJ, Juttner CA (1991). "Expression of the YB5.B8 antigen (c-kit proto-oncogene product ... "Signal transduction-associated and cell activation-linked antigens expressed in human mast cells". Int. J. Hematol. 75 (4): 357 ...
In this article, we have examined the motility-related results of weak power frequency magnetic areas (MFs) on the epidermal development element receptor (EGFR)-private motility system, including the F-actin cytoskeleton, development of invasive protrusions and the amounts of transmission substances in human being amniotic epithelial (FL) cells. F-actin content material and unique distributions. These results had been also connected with adjustments in proteins content material or distribution patterns of the EGFR downstream motility-related signaling substances. All of these results are comparable to those pursuing skin development aspect (EGF) pleasure of the cells and are period reliant. These outcomes recommend that power regularity MF publicity acutely impacts the migration/motility-related actin cytoskeleton reorganization that is certainly governed by the EGFR-cytoskeleton signaling path. As a result, upon the MF publicity, cells are likely altered to end up being set to transfer into a ...
In the early stages of metastasis, cancer cells disseminate from the primary tumor and obtain invasive capabilities that are mediated by multiple events, including changes in cell-cell contact, loss of cell internal polarity, an increase in focal adhesion turnover and acquisition of autonomous motility. The body usually resists metastasis through the actions of a class of proteins known as metastasis suppressors, such as BRMS1 and KISS1 (Jackson, 2007). In this work, we identify another suppressor, the zipcode-binding protein 1 also known as human IMP1 (hereafter referred to as ZBP1/IMP1), which functions to suppress invasiveness.. ZBP1 belongs to a highly conserved family of RNA-binding proteins that has been implicated in many aspects of post-transcriptional regulation of mRNAs (Yisraeli, 2005). ZBP1 directs the localization of β-actin mRNA to the leading edge in a variety of cell types, which results in the asymmetric translation of the β-actin protein and establishes cell polarity ...
Based On A Lie, End Of Freedom, Ação Direta hardcorepunk from São Paulo, Brasil live concert at Casal Joves, La Roca Des Vallès SPA 06 October 2001
I like saving money by finding bargains or making things to decorate my home with. When I came across this bay leaf wreath from Pottery Barn I loved it! This wreath is no longer available on their website. I loved that wreath, but I was confident I could make my own ...
Early studies pointed to the potential of tetraspanins to associate with a wide variety of partner proteins in a tetraspanin web. Not only do tetraspanins associate with each other, but they also associate with many Ig superfamily proteins, proteoglycans, complement regulatory proteins, integrins, growth factors, growth factor receptors, and signaling enzymes (for review see Boucheix and Rubinstein, 2001). Assembly of the tetraspanin web is based on multiple levels of interactions (Serru et al., 1999; Stipp et al., 2001a,b; and references therein). The first level includes primary interactions between specific tetraspanins and other proteins. These interactions are direct, and resist disruption by detergents such as Brij96, digitonin, and/or Triton X-100 (see examples below). Second level interactions are indirect, more numerous, and much more sensitive to disruption by Brij96, digitonin, and/or Triton X-100. Soluble second level complexes (maintained in detergents such as Brij56, Brij99, and ...
You are mistaken. ROCA PSEA could not sinned by default or change of its own previous decisions. Constant practice of any ecclesiastical authority in time to vary between the extremes and acrivia economia on the same issue. After retiring in split MP Metropolitan Laurus Group, formed in 2007 ROCA PSEA (now - it ROCOR Synod chaired by th en. Agafangel: in While the "fragments" of the ROCA as RPATs "ROCA (V)", RTOC IRPTSZ, RosPTs, etc., etc., etc. are schisms and parasinagogi), before taking the "sekachevtsev" are inseparable canonical continuation of that same Supreme Church Authority ROCA authorization th Patriarch Tikhon and educated at Metropolitan. Antonia by Decree # 362. Consequently, since the ROCA PSEA was a same old laws supreme ecclesiastical authority ROCA, it was not obliged to comply strictly with first developed their own decisions, and if necessary they could alter, amend or repeal all. So if the ROCA PSEA decided to take sekachevtsev-general without any yakih, it would not be a ...
The bacterial flagellum is an amazingly complex molecular machine with a diversity of roles in pathogenesis including reaching the optimal host site, colonization or invasion, maintenance at the infection site, and post-infection dispersal. Multi-megadalton flagellar motors self-assemble across the cell wall to form a reversible rotary motor that spins a helical propeller - the flagellum itself - to drive the motility of diverse bacterial pathogens. The flagellar motor responds to the chemoreceptor system to redirect swimming toward beneficial environments, thus enabling flagellated pathogens to seek out their site of infection. At their target site, additional roles of surface swimming and mechanosensing are mediated by flagella to trigger pathogenesis. Yet while these motility-related functions have long been recognized as virulence factors in bacteria, many bacteria have capitalized upon flagellar structure and function by adapting it to roles in other stages of the infection process. Once at their
Roca Labs sold weight-loss powders billed as an alternative to gastric bypass surgery, but one customer shares why she thinks it was a sham
Serotype M3 capsule expression is derepressed by RocA M3 truncation. (A) M3 GAS express more capsule than M1 (n = 5 strains/group); however, capsule levels in M
Compare izumo sperm-egg fusion 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
human CD231 antigen: tetraspanin protein; has the unique potential to modulate HIV-1 infectivity through incorporation into released HIV-1 particles
Title: Investigating the molecular mechanism of COPD in tetraspanin CD9/CD81 DKO mice- a new model for ageing. 6/9 Yuko Tsuchiya. 6/16 Special seminar 15:00 ...
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The tetraspanins are a superfamily of transmembrane proteins with diverse functions and can form extended microdomains within the plasma membrane in conjunction with partner proteins, which probably includes receptors for bacterial adhesins. Neisseria meningitidis, the causative agent of meningococcal disease, attaches to host nasopharyngeal epithelial cells via type IV pili and opacity (Opa) proteins. We examined the role of tetraspanin function in Neisseria meningitidis adherence to epithelial cells. Tetraspanins CD9, CD63, and CD151 were expressed by HEC-1-B and DETROIT 562 cells. Coincubation of cells with antibodies against all three tetraspanin molecules used individually or in combination, with recombinant tetraspanin extracellular domains (EC2), or with small interfering RNAs (siRNAs) significantly reduced adherence of Neisseria meningitidis. In contrast, recombinant CD81, a different tetraspanin, had no effect on meningococcal adherence. Antitetraspanin antibodies reduced the adherence ...
Although tetraspanins are considered to be organizers (in cis) of cellular membranes, their overall job description remains relatively vague. One of the few specific functions that have been clearly established for several members of the tetraspanin family is their regulation (positive or negative) of membrane fusion processes. For example, one of the tetraspanins that we identified to be present at HIV-1 release sites, CD9, is absolutely required for sperm-egg fusion. Although it remains unknown how exactly tetraspanins control fusion processes, it is thought that they do so by manipulating the interactions of fusogenic proteins with other membrane proteins (integral or peripheral). Given these fusion regulation functions, and given that viral infections require the fusion of viral and cellular membranes, we reasoned that tetraspanins might also regulate virus-mediated fusion processes. We thus started to analyse whether overexpression (either transient or stable) or down-regulation of ...
Tetraspanins function as molecular organizers of multi-protein complexes by assembling primary complexes of a relatively low mass into extensive networks involved in cellular signalling. In this paper, we summarize our studies performed on the tetraspanin D6.1A/CO-029/TM4SF3 expressed by rat carcinoma cells. Primary complexes of D6.1A are almost indistinguishable from complexes isolated with anti-CD9 antibody. Indeed, both tetraspanins directly associate with each other and with a third tetraspanin, CD81. Moreover, FPRP (prostaglandin F2α receptor-regulatory protein)/EWI-F/CD9P-1), an Ig superfamily member that has been described to interact with CD9 and CD81, is also a prominent element in D6.1A complexes. Primary complexes isolated with D6.1A-specific antibody are clearly different from complexes containing the tetraspanin CD151. CD151 is found to interact only with D6.1A if milder conditions, i.e. lysis with LubrolWX instead of Brij96, are applied to disrupt cellular membranes. CD151 ...
CD9, a member of the tetraspanin family, is highly expressed on platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin. The association between CD9 and GPIIb-IIIa was analyzed using immunoprecipitations and confocal microscopy. These two proteins were found to associate with each other, particularly at areas of platelet-platelet contact and at the periphery. Confocal analysis revealed CD9 localization was most intense at platelet-platelet contact, as well as in platelet filopodia and lamellipodia, but there is a lack of CD9 at areas of platelet-matrix contact. Co-localization with F-actin decreased as platelets progressed through the stages of spreading. In order to analyze CD9 contributions to platelet function, a Fab fragment was generated from mAb7, an antibody which binds with high affinity to the large extracellular loop of CD9. Fab fragments were used
Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin1, one of the critical regulators of integrin activation, to focal adhesions: CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells.. ...
IN a shock revelation in the ongoing Malaya case a builder has confessed he paid Juan Antonio Roca three million euros for occupancy licences. Fidel San Roman - who faces a nine year prison sentence and 48 million euro fine on charges of bribery and money laundering - ratified all of the payments, one by one, that the prosecutor argued he had made to Roca in exchange for occupancy licences on Marbella apartments.. He told the court that between February and December 2005 he paid the former town planning chief more than three million euros in seven payments of white money taken out of the accounts of his various companies.. "When the homes were ready to be handed over to the buyers, the Town Hall told us that the money was needed, and if it wasnt paid, things could not move forward," explained the 72-year-old. This directly contradicts Rocas earlier claims that payments he received from Roman, as well as Aifos and Construcciones Salamanca, were not made for favours but for advisory ...
Streamline affinity-based exosome immunopurification. With magnetic beads already pre-coupled to antibodies to the tetraspanin proteins CD63, CD81, and CD9, and delivered in a 96-well format, SBIs Exo-Flow96 Tetra IP Kit simplifies high-throughput, antibody-based exosome isolation. Our magnetic bead-coupled anti-CD9 antibodies are extensively validated, and the high-quality Exo-Flow IP kit components ensure reliable, reproducible affinity-based exosome purification directly from serum or plasma. Exosomes can also be purified from other biofluids such as media, urine, and CSF, but must first be concentrated using either ExoQuick-TC® or ultracentrifugation ...
Streamline affinity-based exosome immunopurification. With magnetic beads already pre-coupled to antibodies to the tetraspanin proteins CD63, CD81, and CD9, and delivered in a 32-well format, SBIs Exo-Flow32 Tetra IP Kit simplifies high-throughput, antibody-based exosome isolation. Our magnetic bead-coupled anti-CD9 antibodies are extensively validated, and the high-quality Exo-Flow IP kit components ensure reliable, reproducible affinity-based exosome purification directly from serum or plasma. Exosomes can also be purified from other biofluids such as media, urine, and CSF, but must first be concentrated using either ExoQuick-TC® or ultracentrifugation ...
Tetraspanins are family of small membrane proteins and they are involved in multitude of biological process. Structurally theyare characterized by having four transmembrane domains, short inner and outer loops, one large extra cellular loop containsCCG motif and N and C terminal. Iconic features of these proteins are formation of Tetraspanin Enriched Micro domains(TEMs) by interacting among themselves and with other transmembrane and cytosolic proteins. These domains provide asignaling platform for many important cellular functions such as immune response induction, fertilization, viral infection,maintenance of skin integrity and malignant process. Tetraspanin CD151 is frequently over expressed on cancer cells and isfunctionally linked to cancer metastasis. CD151 forms direct and stable and interaction with integrin molecules and regulatesthe cellular functions. Increasing evidence emerging from in vitro, in vivo and clinical analyses associates that CD151partnership with integrins ?6?1 and ...
The ability of cells to migrate is important for development, neurite formation, immune function, and other processes necessary for the life of an organism. However, the gaining of an inappropriate migratory function, as well as, uncontrolled proliferation and loss of tumor suppression, can lead to cancer. Migration is a multi-step process involving a variety of proteins and other cellular molecules. The basic steps in migration involve: a) filopodia extension and adherence to the extracellular matrix; b) movement of the cell body forward; and c) rear detachment and retraction. (Lauffenburger and Horwitz, 1996) Interactions between tetraspanins and integrins are important in cell adhesion and cell signaling processes in migration. CD9, a member of the tetraspanin family, plays multiple roles in migration, mediating processes like adhesion and filopodia extension though interactions with integrins and other migration associated molecules. One possible model indicates that once an integrin, like ...
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Pierre Fabre Centre dImmunologie (a subsidiary of Pierre Fabre) is developing anti-tetraspanin cluster of differentiation 151 (CD151) antibodies for the
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A subtype of tetraspanin protein that plays a role in cell adhesion, cell motility, and tumor metastasis. It functions in platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg ...
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Candace helps to prosecute patents in the fields of chemistry and materials science, including: batteries, catalysis, OLEDs (organic light-emitting diodes), and solar fuel cells, drawing on her experience in inorganic, organic, and materials chemistry.
Chocolate is not a product, its a process, it doesnt come up by itself, you have to work on its wild nature, which needs to be tamed and domesticated. It has to be brought into this product that we use to make chocolate.. Jordi Roca, Pastry Chef at El Celler de Can Roca (3 Michelin stars). ...
The Wellcome Trust Centre for Mitochondrial Research is built on our long standing clinical and scientific expertise in mitochondrial disease
CD53 is a member of the tetraspan family of molecules, and is expressed by all leucocytes, but is absent from red cells and platelets.Most of the…
Tetraspanins are a superfamily of glycoproteins that function as organisers of membranes by clustering with each other to form tetraspanin-enriched microdomains, into which certain other receptors and signalling proteins are recruited and regulated. Tetraspanin microdomains have been implicated in a range of biological processes including cell signalling, adhesion, intracellular trafficking, cell-cell fusion and viral entry. The tetraspanin CD37 was recently shown to negatively regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal pathogens. The aim of this thesis was to firstly develop a cell line model system to investigate the mechanism by which tetraspanins inhibit dectin-1, and to secondly extend this work to the dectin-1-related CLEC-2, which is essential for platelet thrombus formation and stability. Using a nuclear factor of activated T-cells (NFAT) transcriptional reporter assay in the Jurkat T-cell line, transient over-expression ...
Evidence suggests flow-induced arterial remodeling involves factors released from cells that are intrinsic to the vessel wall and recruited from the bloodstream. Understanding the molecular details has been hampered by the need to study the process in vivo. The present findings suggest that HB-EGF, which has primarily been studied in epithelial and tumor cells, plays a pivotal role in low FINR of the mouse carotid artery. Sustained low flow activated or increased the following elements within the HB-EGF signaling pathway: ROS, the ROS-sensitive HB-EGF sheddase TACE, expression of pro-HB-EGF, HB-EGF immunoreactivity, the HB-EGF receptor EGFR, ERK1/2, and the transcription factor NF-κB. These changes were associated with proliferation, increased leukocyte density, wall hypertrophy, and lumen narrowing. Heterozygous and homozygous deletion of HB-EGF alleles caused "dose-dependent-like" inhibition of FINR (although inhibition of lumen narrowing was in some situations spared (see below), where ...
Abstract Our research is aimed at understanding the mechanism of action of tetraspanins. This is a multi-gene family, which has shown remarkable conservation over evolution and whose members are expressed in mammals, insects and nematodes. Tetraspanins are also widely expressed in most cell types, forming molecular associations with different proteins in the different cell types. The tetraspanin CD81 was originally identified in our laboratory as a receptor that controls cell growth. To better define the role of CD81 we created CD81-deficient mice. These mice have impairments in their immune, nervous and reproductive systems. CD81 has been implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria. CD81 is the putative receptor for HCV, CD81 is also required for infection by malaria. Plasmodium sporozoites mature in the liver to merozoites, the stage that infects red blood cells, this maturation step is CD81-dependent.. Recent Studies CD81 is a widely ...
Formation of the nephron depends upon reciprocal signaling of different morphogens between epithelial and mesenchymal cells inside the renal stem/progenitor cell market. interface EMD-1214063 to get hold of epithelial cells. At the websites the plasma membranes of the mesenchymal and an epithelial cell are linked via tunneling nanotubes. Concerning recognized morphological features in conjunction with included morphogens their transportation cannot longer become explained exclusively by diffusion. Rather it must be sorted relating to biophysical properties of morphogens also to recognized environment. Thus the brand new operating hypothesis can be that morphogens with great solubility such as for example glial cell line-derived neurotrophic element (GDNF) or fibroblast development elements (FGFs) are transferred by diffusion. Morphogens with small solubility such as for example bone morphogenetic proteins (BMPs) are secreted and stored for delivery on demand in illustrated extracellular matrix. ...
Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. Cluster of differentiation Tetraspanin GRCh38: Ensembl ...
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane fusogen.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008 ...
Array ( [CURRENT_CITY] => Москва [IBLOCK_TYPE] => CATALOG [IBLOCK_ID] => 72 [PROPERTY_CODE] => Array ( [0] => DIMENSION_WIDTH [1] => DIMENSION_LENGTH [2] => DIMENSION_DEPTH [3] => DIMENSION_HEIGHT [4] => ANTI_SKID [5] => SKU [6] => EXTERNAL_SKU [7] => AEROMASSAGE [8] => AMOUNT_BATH_AEROJET [9] => MEBEL_BASKET [10] => OVERHEAD_SHOWER [11] => NET_WEIGHT [12] => GROSS_WEIGHT [13] => MOUNTING_BATH [14] => INTERNAL_HEIGHT_SHOWER [15] => ROTATION_SPOUT [16] => PULL_SPOUT [17] => HEIGHT_SPOUT [18] => HEIGHT_PALLET [19] => HEIGHT_PALLET_SM [20] => WARRANTY_TOTAL [21] => WARRANTY_ACRYLIC [22] => WARRANTY_FITTINGS [23] => WARRANTY_GYDROMASSAGE [24] => WARRANTY_PLASTIC [25] => WARRANTY_HEATER [26] => WARRANTY_FAIENCE [27] => WARRANTY_ENAMEL [28] => HYDROMASSAGE_ON_BATH [29] => HYDROMASSAGE_ON_SHOWER [30] => AMOUNT_BATH_JET [31] => AMOUNT_SHOWER_JET [32] => DEPTH_VOLUME [33] => SINK_READY_HOLE [34] => BIDE_READY_HOLE [35] => SINK_DIAMETER_DRAIN [36] => DIAMETER_DRAIN [37] => LENGTH_SPOUT [38] => ...
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When Krainer and postdoctoral researcher Xavier Roca, Ph.D., analyzed SpliceRack, a comprehensive database of all ~200,000 known, functional splice sites found at the beginning of every intron in human genes, they were surprised to find many of these sites that didnt appear to have the right sequence of RNA bases to match U1. Experimental testing of particular examples of these sites showed, however, that they were in fact recognized by U1 and effectively used. These "atypical" sites, in other words, could be spliced to make the correct messenger RNA, despite the apparent mismatch ...
To our knowledge, this study is the first to report a regulatory function of tetraspanin CD151 in mast cells. Moreover, it is one of the first reports, to our knowledge, addressing the signaling mechanism of modulation of mast cell activation by any member of the tetraspanin family. In the present study, we demonstrated that CD151 deficiency exacerbated late-phase allergic inflammation in mice in vivo and enhanced proinflammatory cytokine production by cultured BMMCs ex vivo. Moreover, BMMCs deficient in CD151 showed enhanced and sustained FcεRI-induced ERK1/2 and Akt phosphorylation compared with WT cells. Conversely, CD151 deficiency had no effect on mast cell degranulation or the acute phase of PCA. Thus, our data demonstrate that the tetraspanin CD151 functions to selectively inhibit late-phase anaphylaxis responses and the de novo synthesis of cytokines by activated mast cells.. Mast cells possess mechanisms for fine tuning cellular activation that allow initial FcεRI-mediated signaling ...
Accumulation of T lymphocytes has been demonstrated in atherosclerotic lesions, and T-cell-derived factors appear to modulate atherosclerotic progression.1 2 3 4 5 6 The present in vitro study demonstrates that lyso-PC can selectively upregulate the expression of HB-EGF and IL-2 receptors in T lymphocytes and suggests that this polar phospholipid increase in inflammatory and atherosclerotic lesions27 28 may be an important stimulus for T cells in atherogenesis in vivo.. Recent studies have demonstrated that human T lymphocytes isolated from peripheral blood can synthesize HB-EGF.6 Expression of HB-EGF has been shown in macrophages and SMCs in atherosclerotic lesions,20 and T lymphocytes isolated from atherosclerotic plaques have been shown to produce HB-EGF.29 Lyso-PC, therefore, may be a relevant stimulus to induce the expression of HB-EGF in atherosclerotic lesions, in addition to other pathophysiological stimuli, such as tumor necrosis factor,30 thrombin,31 and platelet-activating factor.32 ...
GNAEDINGER, Silvia y HERBST, Rafael. First Record Of Gymnosperm Woods From The Roca Blanca Formation (Lower Jurassic), Santa Cruz Province, Argentina. Ameghiniana [online]. 2009, vol.46, n.1, pp. 59-71. ISSN 0002-7014.. Three fossil wood species are recognised from the Liassic (Sinemurian- Toarcian) Roca Blanca Formation: Agathoxylon protoaraucana (Brea) Gnaedinger and Herbst nov. comb., Prototaxoxylon pintadense Gnaedinger and Baieroxylon sp. cf. B. chilensis Torres and Philippe. For their secondary anatomical structures these species have close affinities with the Coniferales (Araucariaceae), Taxales and Ginkgoales? respectively. Also, comparisons of Agathoxylon protoaraucana (Brea) Gnaedinger and Herbst and extant Araucaria araucana (Molina) K. Koch showed that both have identical anatomical characters, which suggests a very conservative group.. Palabras clave : Fossil wood; Anatomy; Roca Blanca Formation; Liassic; Patagonia. ...
Previous work demonstrated that egg surface CD9 is essential for sperm-egg fusion (Kaji et al., 2000; Le Naour et al., 2000; Miyado et al., 2000), but nothing is known about how CD9 acts in this system. Egg CD9 could bind in trans to a counter-receptor on sperm as suggested for CD81 on astrocytes interacting with neurons (Kelic et al., 2001). Alternatively, CD9 may function by cis interactions on the egg surface with other egg surface molecules. One egg protein suggested to interact in a physiologically significant way with CD9 is the integrin α6β1 (Chen et al., 1999; Miyado et al., 2000). However, eggs lacking α6β1 fuse normally with sperm, so a role for this integrin in gamete fusion is in doubt (Miller et al., 2000).. The anti-CD9 monoclonal antibody KMC8 blocks sperm-egg fusion (Chen et al., 1999; Miller et al., 2000), and we found that KMC8 binds to constructs containing CD9 EC2, suggesting a role for EC2 in the fusion process. The EC2 constructs, preincubated with sperm, had no ...
CD9, a member of the tetraspanin superfamily of proteins participates in the regulation of cell adhesive functions such as cell migration. The mechanisms underlying CD9 mediated cell migration are not known. In the current study, we investigated the molecular basis for the CD9 promoted cell migration. Our findings show that the phosphatidylinositol-3 kinase (PI-3K) inhibitors, wortamannin and LY294002 inhibited CD9 promoted cell motility in Chinese hamster ovary (CHO) cells. In contrast, inhibitors targeting protein kinase C or mitogen-activated protein kinase had no effect on CD9 driven CHO cell motility. Furthermore, inhibition of PI-3K activity in CHO cells by dominant/negative PI-3K cDNA transfection abolished CD9 mediated pro-migratory effects. Consistent with these observations, CD9 expression in CHO cells and in the rat aortic smooth muscle (RASM) cells induced enhanced phosphorylation of PI-3K substrate, Akt. In CHO cells, CD9 expression also enhanced protein levels and tyrosine phosphorylation
Human immunodeficiency virus type 1 (HIV-1) transmission takes place primarily through cell-cell contacts known as virological synapses. Formation of these transient adhesions between infected and uninfected cells can lead to transmission of viral particles followed by separation of the cells. Alternatively, the cells can fuse, thus forming a syncytium. Tetraspanins, small scaffolding proteins that are enriched in HIV-1 virions and actively recruited to viral assembly sites, have been found to negatively regulate HIV-1 Env-induced cell-cell fusion. How these transmembrane proteins inhibit membrane fusion, however, is currently not known. As a first step towards elucidating the mechanism of fusion repression by tetraspanins, e.g., CD9 and CD63, we sought to identify the stage of the fusion process during which they operate. Using a chemical epistasis approach, four fusion inhibitors were employed in tandem with CD9 overexpression. Cells overexpressing CD9 were found to be sensitized to inhibitors
We hypothesized that the first two transmembrane domains of tetraspanins might interact with each other because: a) consecutive TM domains frequently associate in known protein 3D structures [35], and b) they both contain a series of highly conserved amino acids - several Gly residues and an Asn residue (Figure 1). Conserved Gly residues are a frequent theme in the organization of interacting transmembrane domains. Analysis of 3D helix packing in polytopic membrane proteins reveals that Gly residues tend to localize in buried positions, especially at the helix-helix interfaces and helix crossing points [37, 38]. Due to the absence of a side chain, Gly provides a flat surface for packing of a side chain from another residue, without loss of side-chain entropy upon interaction. The most common Gly-containing motif is GxxxG [39, 40]. In glycophorin A (GpA), the major glycoprotein in erythrocyte cell membranes, Gly79 and Gly83 are part of the LIxxGVxxGVxxT sequence that promotes homodimerization of ...
Despite being implicated in multiple types of human epithelia-origin cancer, laminin-binding (LB) integrins (e.g., α3α1 and α6β4) have rarely been investigated for their roles in human ovarian tumors. More recently, we and others have shown that CD151, a member of the tetraspanin family, not only forms tight surface complexes with these adhesion receptors, but also mediates the malignancy of human carcinomas largely in a LB integrin-dependent manner. Here we report our studies on the role of CD151 in human ovarian cancer. Initially, we stained human ovarian tumor tissue microarrays with CD151-specific antibody. Our data showed that the majority of ovarian tumors exhibited a reduced expression of CD151 protein, compared to the fallopian tube, implying a putative suppressing role of this tetraspanin in ovarian cancer. With this hint we next evaluated the impact of CD151 ablation on the behaviors and proliferation of cultured human ovarian cancer cells. While CD151 removal had a minimal impact ...
CD82 a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. Note: This description may include information from UniProtKB ...
G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene. GPR56 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GPR56 is expressed in liver, muscle, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells. GPR56 binds transglutaminase 2 to suppress tumor metastasis and binds collagen III to regulate cortical development and lamination. GPR56 couples to Gαq/11 protein upon association with the tetraspanins CD9 and CD81. Forced GPR56 ...
CDCP1 a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem ...
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008 ...
Do zakończenia tegorocznych wakacji pozostało już tylko kilka dni. W czasie, gdy uczniowie są myślami przy powrocie do szkół, a cała...
Sequencing your DNA may be one way to provide better diagnostic tools but there are other methods and one such is by monitoring the blood of individuals. Dr Simon Goldman from Abcodia joins us in the studio to tell us about a project hes been working on called ROCA that enables early and reliable detection of ovarian cancer using an algorithm.
Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger ...
One of the key concepts in tetraspanin functions is the formation of a tetraspanin network (or web) by tetraspanins and their partner proteins (Rubinstein et al., 1996; Maecker et al., 1997; Hemler, 2005). Studies have been performed to delineate the levels and strengths of interactions in these networks (Claas et al., 2001; Charrin et al., 2003; Yang et al., 2004). The existing data indicate that there are three levels of interactions: the primary interaction between a tetraspanin and its partner, the secondary interaction between the primary complexes, and the tertiary interaction between these secondary complexes (Hemler, 2003; Levy and Shoham, 2005; Martin et al., 2005). However, most of the existing studies relied on examinations of the tetraspanin complexes based on their detergent resistance, which are relatively nonspecific and insensitive. Our current structural data and molecular model of the UP tetraspanin complexes have revealed in molecular details several levels of interactions in ...
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March explained to me that he became interested in popular anatomical museums when he happened upon some ephemera related to The Museo Roca at a local antique shop in 2008. He has since done a great deal of research, including some in tandem with Alfons Zarzoso--curator of the Museu dHistòria de la Medicina de Catalunya--who was the first to introduce me to the topic many years ago. We ended up featuring a number of pieces from this collection for the Wellcome Collections 2009 exhibition Exquisite Bodies: or the Curious and Grotesque History of the Anatomical Model ...
Moksha Ranasinghe Probing the Lncap Prostate Cancer Library for Interactants with the Cytoplasmic Tail Domains of the Heparin Binding Human Epidermal Growth Factor-Like Growth Factor and Amphiregulin, Using the Yeast Two-Hybrid System ...
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TSPAN7 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 110 amino acids(113-213a.a.)and having a molecular mass of 12.6kDa.
Lanuti, P., Simeone, P., Rotta, G., Almici, C., Avvisati, G., Azzaro, R., Bologna, G., Budillon, A., Di Cerbo, M., Di Gennaro, E., Di Martino, M. L., Diodato, A., Doretto, P., Ercolino, E., Falda, A., Gregorj, C., Leone, A., Losa, F., Malara, N., Marini, M. & 18 others, Mastroroberto, P., Mollace, V., Morelli, M., Muggianu, E., Musolino, G., Neva, A., Pierdomenico, L., Pinna, S., Piovani, G., Roca, M. S., Russo, D., Scotti, L., Tirindelli, M. C., Venturella, R., Vitagliano, C., Zullo, F., Marchisio, M. & Miscia, S., Dec 1 2018, In : Scientific Reports. 8, 1, 5823.. Research output: Contribution to journal › Article ...
Resumen: La variabilidad genética adaptativa en especies es un componente fundamental de la biodiversidad, pero ha sido ignorado en estudios dirigidos a evaluar y predecir la biodiversidad del bosque. Empleamos regresión factorial y modelos de estructuración para probar caracteres ambientales fácilmente cuantificables, tales como los atributos ecológicos, para predecir la variación genética adaptativa entre poblaciones de especies de árboles ( Eucaliptus delegatensis). La variabilidad adaptativa fue definida en base a la variación en la capacidad de crecimiento promedio de 68 poblaciones y de la población por interacción ambiental a lo largo de siete diferentes ambientes. Los mejores caracteres de variabilidad fueron las medidas del rango de radiación solar y temperatura, cada una prediciendo mas del 50% de variabilidad genética dentro de la especie. Los tipos de roca y sotobosque, ya sean empleados solas o en combinación con otras covariables, también fueron muy eficientes en la ...
After losing the title of the finest eating establishment in the world to Spains Celler de Can Roca last year, Copenhagens Noma restaurant regained the title in 2014. Held annually since 2002, the Worlds 50 Best Restaurants awards are the Oscars of the food world
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Pancreatic adenocarcinomas have a poor prognosis due to early and massive spread into the peritoneal cavity and settlement in the liver (1, 3, 4). Several reports indicate a contribution of α3β1 and α6β4 (5, 42). We noted in a highly metastatic rat pancreatic adenocarcinoma line that α6β4 associated with CO-029 after PKC activation. The complex became internalized and cells changed from a sessile towards a motile phenotype (34). In view of these observations, we speculated that coexpression of integrins, particularly of α6β4, and tetraspanins, may be a key element in the metastatic behavior of pancreatic adenocarcinoma. Here, we show high expression of several integrins and tetraspanins in pancreatic adenocarcinoma tissues and lines in comparison to normal pancreatic and chronic pancreatitis tissues. Furthermore, laminin 5-binding integrins were found in association with tetraspanins. However, only the α6β4-CD151/CO-029 associations were strengthened by PKC activation, which was ...
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Tetraspanin microdomains control localized protein kinase C signaling in B cells.
Clone REA563 recogizes the mouse CD63 antigen. It belongs to the tetraspanin transmembrane 4 superfamily (TM4SF) of proteins, which are characterized by four membrane spanning domains. Tetraspanins, via various homotypic and heterotypic interactions, regulate the spatial location and trafficking of associated transmembrane partners, eventually regulating and co-ordinating various signaling pathways. Interaction of CD63 with other membrane proteins or adaptors regulates cell activities such as adhesion, migration, and degranulation. CD63 is expressed on monocytes, macrophages, endothelium, fibroblasts, osteoclasts, smooth muscle cells, and activated platelets. Additional information: Clone REA563 displays negligible binding to Fc receptors - USA
fertilin: fertilin is a sperm surface protein involved in sperm-egg fusion; consists of two subunits, fertilin alpha and beta, both of which belong to the metalloprotease-disintegrin protein family; RefSeq NM_172126 (Adam1a, mouse); NM_172125 (Adam1b, mouse); NM_009618 (Adam2, mouse); NM_020078 (Adam1a, rat); NM_020077 (Adam2, rat); NM_001464 (ADAM2, human)
Vogelbusch Biocommodities GmbH has announced the opening of a corn ethanol plant in Alejandro Roca, Argentina, that is based on its state-of-the-art technology that is designed for optimal performance in terms of primary energy and water consumption.
Zanoletti E, Mazzoni A, Martini A, Abbritti RV, Albertini R, Alexandre E, Baro V, Bartolini S, Bernardeschi D, Bivona R, Bonali M, Borghesi I, Borsetto D, Bovo R, Breun M, Calbucci F, Carlson ML, Caruso A, Carlson ML, Caye-Thomasen P, Cazzador D, Champagne PO, Colangeli R, Conte G, DAvella D, Danesi G, Deantonio L, Denaro L, Di Berardino F, Draghi R, Ebner FH, Favaretto N, Ferri G, Fioravanti A, Froelich S, Giannuzzi A, Girasoli L, Grossardt BR, Guidi M, Hagen R, Hanakita S, Hardy DG, Iglesias VC, Jefferies S, Jia H, Kalamarides M, Kanaan IN, Krengli M, Landi A, Lauda L, Lepera D, Lieber S, Lloyd SLK, Lovato A, Maccarrone F, Macfarlane R, Magnan J, Magnoni L, Marchioni D, Marinelli JP, Marioni G, Mastronardi V, Matthies C, Moffat DA, Munari S, Nardone M, Pareschi R, Pavone C, Piccirillo E, Piras G, Presutti L, Restivo G, Reznitsky M, Roca E, Russo A, Sanna M, Sartori L, Scheich M, Shehata-Dieler W, Soloperto D, Sorrentino F, Sterkers O, Taibah A, Tatagiba M, Tealdo G, Vlad D, Wu H, Zanetti D. ...
Inter provon perseri. Nga koha e Tripletes e deri tani, nga Appiano Gentile kane kaluar shume mbrojtes krahu qe kane deshtuar. Tani i perket Dalbert dhe Cancelo per te provuar te ndryshojne historine, sic nenvizon Corriere dello Sport:. … Lexo me shume. ...
Although large scale informatics studies on introns can be useful in making broad inferences concerning patterns of intron gain and loss, more specific questions about intron evolution at a finer scale can be addressed using a gene family where structure and function are well known. Genome wide surveys of tetraspanins from a broad array of organisms with fully sequenced genomes are an excellent means to understand specifics of intron evolution. Our approach incorporated several new fully sequenced genomes that cover the major lineages of the animal kingdom as well as plants, protists and fungi. The analysis of exon/intron gene structure in such an evolutionary broad set of genomes allowed us to identify ancestral intron structure in tetraspanins throughout the eukaryotic tree of life. We performed a phylogenomic analysis of the intron/exon structure of the tetraspanin protein family. In addition, to the already characterized tetraspanin introns numbered 1 through 6 found in animals, three ...
Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinsons disease, on cell motility. A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parsons lab at Kings College London, learning new cell migration assays and analysing fibroblasts cultured from individuals with Parkinsons. Read more on her story here. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 30 Nov 2017. Apply now!. ...
Heparin Binding EGF-like growth factor (HB-EGF), 50 µg. HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes.
FtsX is a ubiquitous bacterial integral membrane protein involved in cell division that regulates the activity of peptidoglycan (PG) hydrolases. FtsX is representative of a large group of ABC3 superfamily proteins that function as "mechanotransmitters," proteins that relay signals from the inside to the outside of the cell. Here, we present a structural characterization of the large extracellular loop, ECL1, of FtsX from the... ...
Ishikawa, K., Miyamoto, M., Yoshioka, T., Kato, T., Kaji, M., Ohbuchi, T., Hirano, S., Itoh, T., Dosaka-Akita, H. and Kondo, S. (2008), Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis. Cancer, 113: 530-541. doi: 10.1002/cncr.23618 ...
One of the most serious and rigorous sections in pig333. Every week, illustrators Pere Roca and Jonny Hawkins offer us some of the funniest cartoons of the pig sector. ...
Date: May 1, 2005 Author: McNeil, Mary ; Yazbeck, Abdo S. ; Gwatkin, Davidson R. ; Excobar, Maria Luisa ; Coady, David P. ; Filmer, Deon P. ; Rawlings, Laura B. ; Nathan, Rose ; Mponda, Hadji ; Mshinda, Hassan ; Diop, Francois Pathe ; Butera, Jean Damascene ; Bhushan, Indu ; Bloom, Erik ; Loevinsohn, Benjamin ; Schwartz, J. Brad ; Meessen, Bruno ; Ir, Por ; Ranson, M. Kent ; Joshi, Palak ; Shah, Mittal ; Shaikh, Yasmin ; Malhotra, Anju ; Mathur, Sanyukta ; Pande, Rohini ; Roca, Eva ; Koro, Emmanuel ...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
TY - JOUR. T1 - Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. AU - Hatakeyama, Hiromitsu. AU - Cheng, Haixia. AU - Wirth, Pamela. AU - Counsell, Ashley. AU - Marcrom, Samuel R.. AU - Wood, Carey Burton. AU - Pohlmann, Paula R.. AU - Gilbert, Jill. AU - Murphy, Barbara. AU - Yarbrough, Wendell G.. AU - Wheeler, Deric L.. AU - Harari, Paul M.. AU - Guo, Yan. AU - Shyr, Yu. AU - Slebos, Robbert J.. AU - Chung, Christine H.. PY - 2010. Y1 - 2010. N2 - Background: We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamous cell carcinoma (HNSCC). Methodology/Principal Findings: Genome-wide changes in gene and miR expression were determined in cetuximabsensitive cell line, SCC1, and ...
Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen entry into host cells, including hepatitis C virus (HCV) entry into hepatocytes. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma. HCV entry into hepatocytes is a complex process that requires the coordinated interaction of viral and host factors for the initiation of infection, including CD81, scavenger receptor BI, claudin-1, occludin, membrane-bound host cell kinases, Niemann-Pick C1 Like 1, Harvey rat sarcoma viral oncogene homolog (HRas), CD63 and transferrin receptor 1. Furthermore, recent data in HCV model systems have demonstrated that targeting critical components of tetraspanins and associated cell membrane proteins open new avenues to prevent and treat viral infection.
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor ...
Regional Office assessments are much like the accreditation reviews that occur at health facilities nationwide. Every 1 to 2 years, Health Support and Accommodation Support Contractor personnel visit each center as part of a Regional Office Center Assessment (ROCA) team. You can expect to have student health records (SHRs), appointment books, and other records audited during this assessment. When the ROCA is announced, an assessor will contact you to set up an interview appointment with various members of the Health and Wellness Center staff. In preparation for the health and wellness assessment, you will also be requested to complete various Pre-ROCA Questionnaires that can be downloaded from the Job Corps Health and Wellness website. This team uses the Job Corps Program Assessment Guide (PAG) and Health and Wellness ROCA tools to conduct an overall assessment of your centers Health and Wellness Program. The PAG is located on the Job Corps Community website. The PAG and ROCA tools are designed ...
This study reports three main findings that provide insights into the molecular mechanism of leukocyte transmigration. First, endothelial ADAM10 promotes transmigration of T lymphocytes, but not B lymphocytes or neutrophils, in an in vitro flow assay. Second, this function of ADAM10 is mediated via its substrate VE-cadherin, but not CX3CL1 and CXCL16. Third, Tspan5 and Tspan17 regulate VE-cadherin expression and promote lymphocyte transmigration, but the other four ADAM10-interacting TspanC8 tetraspanins do not.. The previously proposed role for endothelial ADAM10 in leukocyte transmigration is based on in vitro transwell assays in the absence of flow (6, 10, 11). One of these studies showed a positive role for endothelial ADAM10 using unstimulated HUVECs at passage two to four, following ADAM10 knockdown or inhibition, and cultured human T cell blasts (6). A second study reported a positive role for endothelial ADAM10 using HUVECs up to passage four, stimulated with IFN-γ and TNF-α and ...
Since, we have recently established knocked out mice for TI-VAMP (Danglot et al., J Neurosci, 2012) which are viable in contrast to Synaptobrevin KO. We are now planning to unravel the specificity of this two neuronal v-SNARE at both pre and post-synaptic sites. Indeed, these two SNAREs are also expressed in post-synaptic compartments which constitute a place of intense trafficking. However, the membrane compartments and the molecular mechanisms involved are still poorly defined. In epithelial cells, we previously showed that TI-VAMP depletion reduces the cell surface amount of tetraspanins known to control EGF receptor localization in microdomains. Depletion of TI-VAMP or tetraspanin CD82 restrains EGFR diffusion at the cell surface as observed by Quantum dots video-microscopy. This is correlated with an increase recruitment of endocytic machinery and impaired MAPK signaling. These results highlight the role of TI-VAMP in receptor traficking, and support a model in which entry of receptors in ...
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Nakagawa, Kenji; Gonzalez Roca, Eva; Souto, Alejandro; Kawai, Toshinao; Umebayashi, Hiroaki; Campistol Plana, Jaume; Cañellas, Jeronima; Takei, Syuji; Kobayashi, Norimoto; Callejas Rubio, José Luis; Ortego Centeno, Norberto; Ruiz Ortiz, Estíbaliz; Rius, Fina; Antón López, Jordi; Iglesias, Estibaliz; Jiménez Treviño, Santiago; Vargas, Carmen; Fernandez Martin, Julian; Calvo, Inmaculada; Hernández Rodríguez, José; Mendez, María; Dordal, María Teresa; Basagaña, Maria; Bujan, Segundo; Yashiro, Masato; Kubota, Tetsuo; Koike, Ryuji; Akuta, Naoko; Shimoyama, Kumiko; Iwata, Naomi; Saito, Megumu K.; Ohara, Osamu; Kambe, Naotomo; Yasumi, Takahiro; Izawa, Kazushi; Kawai, Tomoki; Heike, Toshio; Yagüe, Jordi; Nishikomori, Ryuta; Aróstegui Gorospe, Juan Ignacio ...
Nakagawa, Kenji; Gonzalez Roca, Eva; Souto, Alejandro; Kawai, Toshinao; Umebayashi, Hiroaki; Campistol Plana, Jaume; Cañellas, Jeronima; Takei, Syuji; Kobayashi, Norimoto; Callejas Rubio, José Luis; Ortego Centeno, Norberto; Ruiz Ortiz, Estíbaliz; Rius, Fina; Antón López, Jordi; Iglesias, Estibaliz; Jiménez Treviño, Santiago; Vargas, Carmen; Fernandez Martin, Julian; Calvo, Inmaculada; Hernández Rodríguez, José; Mendez, María; Dordal, María Teresa; Basagaña, Maria; Bujan, Segundo; Yashiro, Masato; Kubota, Tetsuo; Koike, Ryuji; Akuta, Naoko; Shimoyama, Kumiko; Iwata, Naomi; Saito, Megumu K.; Ohara, Osamu; Kambe, Naotomo; Yasumi, Takahiro; Izawa, Kazushi; Kawai, Tomoki; Heike, Toshio; Yagüe, Jordi; Nishikomori, Ryuta; Aróstegui Gorospe, Juan Ignacio ...
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HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant mouse HB-EGF produced in E. coli is a single, non-glycosylated polypeptide chain of 86 amino acids (63-148 a.a.) and a molecular mass of 9.8 kDa. It has bee purified by proprietary chromatographic ...

CD9 - CD9 antigen - Bos taurus (Bovine) - CD9 gene & proteinCD9 - CD9 antigen - Bos taurus (Bovine) - CD9 gene & protein

sp,P30932,CD9_BOVIN CD9 antigen OS=Bos taurus OX=9913 GN=CD9 PE=2 SV=2 ... CD9 antigen1 Publication. ,p>Manually curated information that is based on statements in scientific articles for which there is ... "Molecular cloning of the bovine CD9 antigen from ocular ciliary epithelial cells.". Martin-Alonso J.M., Hernando N., Ghosh S., ... "Molecular cloning of the bovine CD9 antigen from ocular ciliary epithelial cells.". Martin-Alonso J.M., Hernando N., Ghosh S., ...
more infohttps://www.uniprot.org/uniprot/P30932

endothelial and epithelial cells. CD9 antigen modulates cell adhesion - Polo-Like Kinases and Aurora Kinases in Cancer Therapyendothelial and epithelial cells. CD9 antigen modulates cell adhesion - Polo-Like Kinases and Aurora Kinases in Cancer Therapy

... impartial antigens are crucial for PIV-induced security, Mouse monoclonal to CD9.TB9a reacts with CD9 ( p24), a member of the ... CD9 antigen modulates cell adhesion. To further understand the systems of formalin-inactivated stage I (PI) vaccine. To further ... CD9 antigen modulates cell adhesion, expressed on platelets and weakly on B-cells. It also expressed on eosinophils, Hoechst ... CD9 antigen modulates cell adhesion, expressed on platelets and weakly on B-cells. It also expressed on eosinophils, migration ...
more infohttp://technumber.com/tag/endothelial-and-epithelial-cells-cd9-antigen-modulates-cell-adhesion/

endothelial and epithelial cells. CD9 antigen modulates cell adhesionendothelial and epithelial cells. CD9 antigen modulates cell adhesion

CD9 antigen modulates cell adhesion Supplementary MaterialsSupporting Information. key next step in the development of this. ... CD9 antigen modulates cell adhesion, expressed on platelets and weakly on B-cells. It also expressed on eosinophils, migration ... CD9 antigen modulates cell adhesion, expressed on platelets and weakly on B-cells. It also expressed on eosinophils, migration ... CD9 antigen modulates cell adhesion, migration and platelet activation. GM1CD9 triggers platelet activation resulted in ...
more infohttp://www.aboutsciencenow.info/index.php/tag/endothelial-and-epithelial-cells-cd9-antigen-modulates-cell-adhesion/

Gentaur Molecular :GenWay \ CD9 - Mouse monoclonal [MEM - 61] to CD9; p24; Leukocyte antigen MIC3; Motility-related protein;...Gentaur Molecular :GenWay \ CD9 - Mouse monoclonal [MEM - 61] to CD9; p24; Leukocyte antigen MIC3; Motility-related protein;...

... to CD9; p24; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29 Monoclonal \ 20-272-192352 for ... CD9 - Mouse monoclonal [MEM - 61] to CD9; p24; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan- ... CD9 - Mouse monoclonal [MEM - 61] to CD9; p24; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan- ... CD9 - Mouse monoclonal [MEM - 61] to CD9; p24; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan- ...
more infohttp://www.antibody-antibodies.com/product1901041-search-CD9%20_%20Mouse%20monoclonal%20%5BMEM%20_%2061%5D%20to%20CD9

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility.The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility.

Antigens, Cd9. A subtype of tetraspanin proteins that play a role in cell adhesion, cell motility, and tumor metastasis. CD9 ... A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development ... Spontaneously and After Stimulation by an CMV Antigen ... antigens take part in the process of platelet activation and ...
more infohttps://www.bioportfolio.com/resources/pmarticle/1918097/The-Role-of-PAR2-in-TGF-1-Induced-ERK-Activation-and-Cell.html

CD9 - Tetraspanin - Alligator sinensis (Chinese alligator) - CD9 gene & proteinCD9 - Tetraspanin - Alligator sinensis (Chinese alligator) - CD9 gene & protein

Name:CD9Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/ ... tr,A0A1U7S404,A0A1U7S404_ALLSI Tetraspanin OS=Alligator sinensis OX=38654 GN=CD9 PE=3 SV=1 ...
more infohttps://www.uniprot.org/uniprot/A0A1U7S404

Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...

CD9 antigen (p24). CD9. 39389_at. −2.7. CD86 antigen (CD28 antigen ligand 2, B7-2 antigen). CD86. 36270_at. −3.4. ... CD80 antigen (CD28 antigen ligand 1, B7-1 antigen). CD80. 35015_at. 4.7. ... CD209 antigen-like. CD209L. 39270_at. nc. CD36 antigen (collagen type I receptor, thrombospondin receptor). CD36. 36656_at. nc ... CD47 antigen (Rh-related antigen, integrin-associated signal transducer). CD47. 37890_at. 1.9. ...
more infohttp://www.jimmunol.org/content/181/1/698/tab-figures-data

KEGG BRITE: CD Molecules - Homo sapiens (human)KEGG BRITE: CD Molecules - Homo sapiens (human)

T-cell surface glycoprotein CD8 beta chain K06460 CD9; CD9 antigen K01389 MME; neprilysin [EC:3.4.24.11] K05718 ITGAL; integrin ... CD79A antigen K06507 CD79B; CD79B antigen K05412 CD80; CD80 antigen K06508 CD81; CD81 antigen K06509 KAI1; CD82 antigen K06510 ... CD300 antigen K06719 CD300; CD300 antigen K06719 CD300; CD300 antigen K06719 CD300; CD300 antigen K06721 CLEC10A; C-type lectin ... CD96 antigen K08446 ADGRE5; CD97 antigen K06519 SLC3A2; solute carrier family 3, member 2 K06520 CD99; CD99 antigen K06521 ...
more infohttps://www.genome.jp/kegg-bin/get_htext?hsa04090+4486

Patent EP0226288A2 - Means and method of testing for cystic fibrosis based on genetic linkage - Google PatentsPatent EP0226288A2 - Means and method of testing for cystic fibrosis based on genetic linkage - Google Patents

1-4, 1985, pages 587-588, CH; C. BOUCHEIX et al.: "Assignment of the gene coding for the human cell surface antigen CD9(p24) to ...
more infohttp://www.google.com.au/patents/EP0226288A2?cl=en

Deglycosylation analysis of cellular and exosomal PSMAs | Open-iDeglycosylation analysis of cellular and exosomal PSMAs | Open-i

Antigens, CD9/biosynthesis. *Cell Line, Tumor. *Cell Membrane/metabolism/ultrastructure. *DNA-Binding Proteins/biosynthesis ... Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression ... Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression ... The vesicular structures of exosomes were identified by electron microscopy, and exosomal marker protein CD9 and tumor ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3928468_IJO-44-03-0918-g02&req=4

ENSDARG00000044990 - Zebrafish Mutation Project - Wellcome Sanger InstituteENSDARG00000044990 - Zebrafish Mutation Project - Wellcome Sanger Institute

Cd81, Cd9, Tspan2. Mouse Descriptions:. CD81 antigen Gene [Source:MGI Symbol;Acc:MGI:1096398]. CD9 antigen Gene [Source:MGI ... CD81, CD9, TSPAN2. Human Descriptions:. CD81 molecule [Source:HGNC Symbol;Acc:1701]. CD9 molecule [Source:HGNC Symbol;Acc:1709] ...
more infohttps://www.sanger.ac.uk/sanger/Zebrafish_Zmpgene/ENSDARG00000044990

WO2001061052A1 - Dna arrays for determining drug selectivity 
        - Google PatentsWO2001061052A1 - Dna arrays for determining drug selectivity - Google Patents

Other CD9 antigen -190 -180. Other Human chromatin assembly factor-I p60 subunit mRNA, 034 -171 complete cds ... Other TUMOR-ASSOCIATED ANTIGEN L6 007 034 056. These genes/ESTs exhibited a constant increase in expression ratio across the ...
more infohttps://patents.google.com/patent/WO2001061052A1/en

Identifying components of the hair-cell interactome involved in cochlear amplification | BMC Genomics | Full TextIdentifying components of the hair-cell interactome involved in cochlear amplification | BMC Genomics | Full Text

... and CD9 antigen (CD9 or Tspan29). A typical tetraspanin has four transmembrane domains. They are distributed in virtually all ... The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. J Neurosci ... carcinoembryonic antigen-related cell adhesion molecule 16), although no functional information is reported. Other clones are ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-127

Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNβ-responsive genes in peripheral blood...Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNβ-responsive genes in peripheral blood...

Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular ...
more infohttps://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-6-18

basal cell adenoma morphologic abnormality 2005:2010[pubdate] *count=100 - BioMedLib™ search enginebasal cell adenoma morphologic abnormality 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD9; 0 / CD9 protein, human; 0 / Membrane Glycoproteins; 0 / Neoplasm ... CONCLUSIONS: The antigen profile of these tumors closely regard with other variants of salivary gland adenomas, such as ... MeSH-major] Antigens, CD / analysis. Membrane Glycoproteins / analysis. Neoplasm Proteins / analysis. Parotid Gland / chemistry ... OBJECTIVE: Evaluate the antigen profile of cellular population from basal cell adenomas. ...
more infohttp://www.bmlsearch.com/?kwr=basal+cell+adenoma+morphologic+abnormality+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Code System ConceptCode System Concept

Cluster of differentiation antigen 9 Current Synonym true false 1231083016 CD9 - Cluster of differentiation antigen 9 Current ... Lymphocyte antigen CD9 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD9 (substance). ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=52160001

hcmr - Bicolor damselfishhcmr - Bicolor damselfish

CD9 (CD9 antigen). Organism. Stegastes partitus (Bicolor damselfish ). GO term(s). Molecular Function: GO:003674. Cellular ...
more infohttp://fish-it.org/hcmr/genedetails.php?seq_id=505

HOGENOM: BOVIN5 113 PE30HOGENOM: BOVIN5 113 PE30

3, Last annotation update) DE RecName: Full=CD9 antigen;AltName: CD_antigen=CD9; (BOVIN5_113.PE30). GN Name=CD9; OS BOS TAURUS ... CD9_BOVIN CC -!- FUNCTION: Involved in platelet activation and aggregation. CC Regulates paranodal junction formation. Involved ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=BOVIN5_113_PE30&db=HOGENOM&ident=ACNUC1829

Molecule InformationMolecule Information

Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules. ... GENE_NAME : CD9. CD_NAME : CD9. DESC: CD9 antigen (p24) OTH_NAMES: BA2; DRAP-27; MIC3; MRP-1; P24 ... GENE_NAME : CD9. CD_NAME : CD9. CD9 is expressed in several cell types including platelets1-2, B cells3, T cells4, eosinophils1 ... CD9 is hypothesized to play a role in fertilization.8 On immune cells, CD9 participates in TCR and BCR signaling and in antigen ...
more infohttp://hcdm.org/index.php/molecule-information?view=molecule&task=viewmolecule&moleculeid=237&search=

EndoNetEndoNet

Details for receptor: CD9 antigen. *Top. *General information. *External resources. *General information ...
more infohttp://endonet.bioinf.med.uni-goettingen.de/receptor/ENR01200

CD9 - WikipediaCD9 - Wikipedia

CD9 antigen is a protein that in humans is encoded by the CD9 gene. The protein encoded by this gene is a member of the ... CD9 CD9 molecule". Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C (2000). "Severely Reduced Female Fertility in CD9- ... Boucheix C, Benoit P, Frachet P, Billard M, Worthington RE, Gagnon J, Uzan G (1991). "Molecular cloning of the CD9 antigen. A ... Higashihara M, Takahata K, Yatomi Y, Nakahara K, Kurokawa K (1990). "Purification and partial characterization of CD9 antigen ...
more infohttps://en.wikipedia.org/wiki/CD9

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types | Genome Biology...Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types | Genome Biology...

2c). CD9 showed increased variability across all three cell types. The gene encodes the CD9 antigen, a member of the ... While CD9 was found to be hypervariable in all three cell types, CAPN2 and FYN show increased variability only in neutrophils, ... a-c Increased expression variability of the genes CD9, CAPN2, and FYN across three immune cell types. For each cell type, data ... Notable genes among those with hypervariable expression values were CD9 (Fig. 2a), CAPN2 (Fig. 2b), and FYN (Fig. ...
more infohttps://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1156-8

HOGENOM: DANRE18 7 PE18HOGENOM: DANRE18 7 PE18

CD9 antigen (DANRE18_7.PE18) (P24);SubName: DE Full=Uncharacterized protein; . GN Name=cd9a; Synonyms=Dr.27131, cd9; OS DANIO ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=DANRE18_7_PE18&db=HOGENOM&ident=ACNUC1829

Reduced Motility Related Protein-1 (MRP-1/CD9) Gene Expression as a Factor of Poor Prognosis in Non-Small Cell Lung Cancer |...Reduced Motility Related Protein-1 (MRP-1/CD9) Gene Expression as a Factor of Poor Prognosis in Non-Small Cell Lung Cancer |...

Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, ... Reduced Motility Related Protein-1 (MRP-1/CD9) Gene Expression as a Factor of Poor Prognosis in Non-Small Cell Lung Cancer. ... Our data suggest that low MRP-1/CD9 expression by tumors of the lung may be associated with poor prognosis. It is conceivable ... We found that 67 patients had MRP-1/CD9-positive tumors, and that gene expression was reduced in the tumors of the remaining 42 ...
more infohttps://cancerres.aacrjournals.org/content/55/24/6040

Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping | The Journal of ImmunologyMouse Cell Surface Antigens: Nomenclature and Immunophenotyping | The Journal of Immunology

Molecular cloning of the mouse equivalent of CD9 antigen. Thromb. Res. 71: 377. ... Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping Message Subject (Your Name) has forwarded a page to you from ... Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping. Lily Lai, Noosheen Alaverdi, Lois Maltais and Herbert C. Morse ... Cell surface antigens expressed by subsets of pre-B cells and B cells. J. Immunol. 132: 332. ...
more infohttp://www.jimmunol.org/content/160/8/3861
  • Mouse monoclonal to CD9.TB9a reacts with CD9 ( p24), a member of the tetraspan ( TM4SF ) family with 24 kDa MW, expressed on platelets and weakly on B-cells. (technumber.com)
  • In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. (aacrjournals.org)
  • CD49c antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA3 Info with links in the Cell Migration Gateway Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis. (nih.gov)
  • In consideration of these findings, we have now applied reverse transcription-PCR to determine MRP-1/CD9 gene expression in lung cancer. (aacrjournals.org)
  • We found that 67 patients had MRP-1/CD9 -positive tumors, and that gene expression was reduced in the tumors of the remaining 42 individuals. (aacrjournals.org)
  • Horejsí V, Vlcek C. Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. (hcdm.org)
  • Multivariate analysis with the Cox regression model indicated that MRP-1/CD9 positivity correlated better with overall survival rate than did other variables, except lymph node status. (aacrjournals.org)
  • In addition, we found that the primary tumors of almost 50% of the patients had higher MRP-1/CD9 levels than their respective metastatic lymph nodes. (aacrjournals.org)
  • Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion. (hcdm.org)