Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma. (1/129)
Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. The suppression of cell motility by MRP-1/CD9 may cause suppression of the metastasis. As we could not find any reports concerning the expression of MRP-1/CD9 and KAI1/CD82 in oesophageal cancers we investigated their expression in oesophageal specimens. We conducted immunohistochemical staining for MRP1/CD9 against 108 cases of oesophageal squamous cell carcinoma using anti-MRP-1/CD9 monoclonal antibody M31-15, and for KAI1/CD82 against 104 cases using anti-KAI1/CD82 monoclonal antibody C33. To investigate the gradual expression of MRP-1/CD9 and KAI1/CD82, 24 oesophageal dysplasias were immunohistochemically stained using the same method and then investigated. The expression of both MRP-1/CD9 and KAI1/CD82 were positive on the cell membranes of normal oesophageal epithelial cells, but reduced or negative in the cancer cells. Reduced MRP-1/CD9 expressions significantly correlated to tumour depth (P = 0.0009). We found a significantly greater number of reduced or negative expression of MRP-1/CD9 and KAI1/CD82 in lymph node metastatic cases (P = 0.0003 and P= 0.0129, respectively), but not in distant metastatic cases. The 5-year survival rate of MRP-1/CD9-negative and reduced patients was significantly worse than those of positive patients (n = 108, curative cases, RO). Few cases remained KAI1/CD82-positive (9.6%; 10/104) in oesophageal cancer. Twenty (83.3%) and twenty-two (91.7%) cases out of 24 dysplasias were defined as KAI1/CD82-positive and MRP1/CD9-positive, respectively. The decrease in MRP-1/CD9 and KAI1/CD82 expression may facilitate lymph node metastasis in oesophageal squamous cell carcinomas. Knowing the status of the expression of MRP-1/CD9 appears helpful in predicting the prognosis for each patient. (+info)A novel molecular staging protocol for non-small cell lung cancer. (2/129)
A molecular staging protocol using reliable markers is of importance in predicting the prognosis of patients with non-small cell lung cancer (NSCLC) and for instituting their appropriate post-surgical treatment. We analysed tumor tissues from 187 NSCLC patients. The DNA and mRNA were extracted from frozen specimens, and then polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct sequencing were performed to investigate mutations of p53 from exons 5-8, and mutations of K-ras at exon 1. To determine MRP-1/CD9 gene and KA11/CD82 gene expression, which have been postulated to be metastasis suppressor genes, we have applied quantitative RT-PCR. A Cox multivariate regression analysis showed that nodal status, MRP-1/CD9 and K-ras status were significant factors for prognosis (P<0.0001, P=0.0083 and P=0.0004, respectively). Based on these results, we classified the patients into three groups according to their MRP-1/ CD9 and K-ras status. Patients with both MRP-1/CD9 positive and wild K-ras tumors were defined as group A, patients with either reduced MRP-1/CD9 or mutant K-ras tumors were defined as group B and patients with both reduced MRP-1/CD9 and mutant K-ras tumors were designated as group C. This new classification was significantly correlated with the tumor status and pathological stage (P=0.0098 and P=0.0017, respectively). The overall survival rate of the group A patients was significantly better than the group B patients (59.6% vs 27.9%, P=0.0001) and also that of group B patients was better than the group C patients (27.9% vs 20.0%, P=0.0378). This tendency was also found in patients with 110 node-negative NSCLCs (A vs B vs C=75.8% vs 34.9% vs 0.0%, P<0.0001). A Cox multivariate regression analysis in NSCLC patients demonstrated that an evaluation for both MRP-1/CD9 expression and K-ras mutations had a significant prognostic effect as well as nodal status (P<0.0001). (+info)Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. (3/129)
Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and expressing CD82 or CD9 by cDNA transfection. Only CD82- or CD9-expressing cells grown in Gal-supplemented medium showed reduced motility and massive cell death, which are characteristic of apoptosis, after a latent period. Under this condition, endogenous GM3 synthesis was observed as a common factor, and N-glycosylation occurred at a high level in CD82 and to a lesser extent in CD9. Thus, the malignancy-suppressing effect of CD82 or CD9 is based partially on cell motility inhibition and apoptosis induction promoted by concurrent GM3 synthesis and N-glycosylation. (+info)Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines. (4/129)
Nerve growth factor (NGF) is expressed in the prostate, where it appears to be involved in the control of epithelial cell growth and differentiation. NGF production is decreased in prostate tumors. However, the role of this neurotrophin in the control of proliferation and progression of prostate cancers is still a matter of investigation. Prostate adenocarcinomas are telomerase-positive tumors. Chronic exposure of DU145 and PC3 prostate tumor cell lines to NGF resulted in a dramatic down-regulation of telomerase activity. This effect was correlated in terms of concentrations and time with a remarkable down-regulation of cell proliferation both in vitro and in vivo but was not secondary to NGF-induced quiescence. No down-regulation of telomerase activity was, in fact, detectable during serum starvation-induced quiescence. LNCaP cells, which do not express NGF receptors, appear to be insensitive to the actions of NGF. DU145 and PC3 cells do not express the KAI1 metastasis suppressor gene, which is present in the prostate and is progressively lost during the progression of prostate cancers. Chronic NGF treatment strongly induced the reexpression of this gene in these cell lines, and this effect was correlated with the suppression of their invasive potential in vitro. The data presented here suggest that NGF reverts two metastatic prostate cancer cell lines to slowly proliferating, noninvasive phenotypes characterized by a very low telomerase activity and by the expression of the KAI1 metastasis suppressor gene. (+info)Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. (5/129)
The metastasis suppressor gene KAI1 was identified by its ability to inhibit the formation of pulmonary metastases in experimental models for prostatic carcinoma. Down-regulation of this gene may be correlated with the invasive phenotype in melanomas and colon and bladder carcinomas and with the metastatic phenotype in carcinomas of the lung, breast, prostate, and pancreas. The goal of our study was to establish an immunohistochemical method to detect KAI1 expression in archival tissues. Using cell lines with known KAI1 levels and paraffin-embedded KAI1 positive tissues as controls, we observed strong membrane staining in lymphoid follicular centers and squamous epithelia. We then demonstrated the utility of our assay by studying KAI1 expression in 34 lymphoid and 57 squamous lesions. All eight reactive lymph nodes were KAI1 positive. In contrast, three of 13 follicular small cleaved and five of 13 diffuse large cell lymphomas were KAI1 negative. Seventy-nine percent (37 of 47) of invasive squamous cell carcinomas from the lung (n = 15), head and neck (n = 18), and cervix (n = 14) showed extensive KAI1 down-regulation. Loss of KAI1 expression was also found in a subset of 10 high-grade cervical dysplasias. Our data show that (i) immunohistochemistry is a suitable technique for evaluating KAI1 expression in archival tissues; (ii) KAI1 was not expressed in a subset of both low-grade and high-grade lymphomas; and (iii) there was extensive down-regulation of KAI1 in squamous cell carcinomas, suggestive of an important role of the gene in the suppression of invasion in these malignancies. (+info)Loss of KAI1 expression in the progression of colorectal cancer. (6/129)
The transmembrane 4 superfamily member KAI1 (CD82) has been shown to inhibit pulmonary metastases in experimental metastasis models of prostate cancer and melanoma. KAI1 expression is decreased in the progression of common solid epithelial tumors of adulthood, including lung, prostate, breast, esophageal, gastric, pancreatic, and bladder cancers. The purpose of our study was to investigate KAI1 expression in the progression of human colorectal cancer. We first analyzed 20 colorectal cancer cell lines by immunoblot techniques. KAI1 was expressed heterogeneously, with the tumor cell lines having a more complex degree of glycosylation compared with that of the normal colonic tissue. KAI1 was highly expressed in the primary SW480 colon cancer cell line but was down-regulated 15-fold in the matched metastatic SW620 cell line. We also investigated KAI1 protein expression by immunohistochemistry in tissues from 84 patients with colorectal cancer. Each tissue section was assigned a KAI1 mean score (KMS) from 0 to 300 based on the product of the percentage of cells that stained for KAI1 and the intensity of the stain (1, 2, or 3). In 84 patients with colorectal cancer, KAI1 was expressed at high levels in normal colonic mucosa (KMS 226) but was expressed at lower levels in the primary tumors (KMS 65; P < 0.0001). In a subset of 12 patients with stage IV metastatic disease, we observed a progressive down-regulation of KAI1, from the normal adjacent colonic mucosa (KMS 193) to the primary tumor (KMS 72; P = 0.0001) to the liver metastasis (KMS 25; tumor compared with metastasis, P = 0.0135). We found no correlation between loss of KAI1 expression and stage of disease. In 10 patients, we also noted loss of KAI1 expression in the transition from normal colonic mucosa (KMS 237) to adenoma (KMS 174) to carcinoma (KMS 62; P < 0.0167 for all three comparisons). We conclude that the down-regulation of KAI1 occurs early in the progression of colorectal cancer. (+info)Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity. (7/129)
Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of growth factors. The membrane-anchored form of HB-EGF (proHB-EGF) is mitogenically active to neighboring cells as well as being a precursor of the soluble form. In addition to its mitogenic activity, proHB-EGF has the property of binding to diphtheria toxin (DT), serving as the specific receptor for DT. Tetramembrane-spanning protein CD9, a member of the TM4 superfamily, is physically associated with proHB-EGF at the cell surface and up-regulates both mitogenic and DT binding activities of proHB-EGF. To understand this up-regulation mechanism, we studied essential regions of both CD9 and proHB-EGF for up-regulation. Immunoprecipitation experiments revealed that not only CD9 but also other TM4 proteins including CD63, CD81, and CD82 associate with proHB-EGF on the cell surface. However, these TM4 proteins did not up-regulate DT binding activity of proHB-EGF. Transfection of a series of chimeric constructs comprising CD9 and CD81 showed that the major extracellular domain of CD9 is essential for up-regulation. Assays of DT binding activity and juxtacrine mitogenic activity of the deletion mutants of proHB-EGF and chimeric molecules, derived from proHB-EGF and TGF-alpha, showed that the essential domain of proHB-EGF for up-regulation is the EGF-like domain. These results indicate that the interaction of the extracellular domains of both molecules is important for up-regulation. (+info)Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage. (8/129)
The p53 tumor suppressor protein functions to monitor the integrity of the genome. If a damage is detected, p53 binds tightly to specific sequence elements in the DNA and induces the transactivation of genes involved in various growth regulatory processes such as cell cycle progression, DNA repair and apoptosis. A p53-binding site was recently identified in the promoter region of the metastatic suppressor KAI1 gene, suggesting that this gene was a direct transcriptional target of p53. To test the relevance of this hypothesis, we studied the endogenous KAI1 expression in a series of human cell lines with varying p53 status in response to genotoxic treatment as well as in different cellular models exhibiting an inducible p53 activity. Overall, our data indicate that KAI1 expression is not significantly modulated by p53. This observation provides a direct evidence that the presence of a p53-binding site in regulatory domains is not a sufficient criteria to define a p53-transcriptional target gene. (+info)
Defining Regulatory Elements in the Human KAI1 (CD 82) Metastasis Suppressor Gene<...
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2<...
Learning therapeutic lessons from metastasis suppressor proteins. - PubMed - NCBI
Correction: De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells ...
Education | Catalog 2014-2015 | PLU
SOL Search
PLU Codes Dont Indicate GMO Produce | Food Renegade
Kai Kai Lyrics Sharon Needles
Meet BGAs Plant Manager Kai Spande -
MidEngineCorvetteForum.com
Reaktor | Kai Niggemann
See Kai Run Kids Dane (Toddler/Little Kid) | Zappos.com
Kai Atakis SUKI! on Tokyo Otaku Mode (TOM)
Health & Medical | Alaskan Klee Kai Association of America
Tergurid - Википедија, слободна енциклопедија
Transcriptional regulation of metastatic [Id]entity by KLF17
The Hellenic Radio (ERA): News in Greek, 10-01-16
KAI FU MACHINERY INDUSTRIAL CO., LTD. - Power Crushers, Double Degasification Granule-Making Machine for Treatment of Plastic,...
KAi??pa Levitra Soft Utan Recept - BAi??sta priser fAi??r utmAi??rkt kvalitet | WildlyCapableWomen.com
Kai Zhangs Profile | Stanford Profiles
Amix Fat táplálékkiegészítő és tartozékai - Árak, keresés ~| DEPO
TheHogs.net - View topic - Kai Forbath - New Kicker
Galatians 3, 28 : Koine and Biblical Greek
Plu Runs - CoolRunning Forums
PLU - 卓悅香港貓 HKMall
Opportunity | PLU Chemistry
Rilla waldorf babái és textiljátékai: Tündérek
Rilla waldorf babái és textiljátékai: Kékince 2. bozsinak a meskára
http://ufdc.ufl.edu/UF00027796/00001
Kancerogenas-Carcinogen | Maistologija
CFML differences between Railo and ColdFusion 9/10 (Part 2)
1 - Segnali operativi forex a pagamento
2 diabetas ir svorio kritimas, Svorio netekimas t2dm
Mini Mafia #6 | Page 73 | DLP
KAI1/CD82, Metastasis Suppressor Gene as a Therapeutic Target for Non-Small-Cell Lung Carcinoma.
PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells | Biochemical Journal
Evidence for protein 4.1B acting as a metastasis suppressor | Journal of Cell Science
Plus it
KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases<...
Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis | PNAS
EGF induces microRNAs that target suppressors of cell migration: MiR-15b targets MTSS1 in breast cancer<...
Antigens, CD82 - Medical Dictionary online-medical-dictionary.org
KAI-43140: Interline Transfer CCD Image Sensor, 43.1 MP
Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes | SpringerLink
PLU DH Assignments | Digital Humanities Lab | PLU
Kai Perfume Kai Rose Body Buffer | b-glowing
2Sam/K 1:1
SCIndeks - Članak
BAi??sta pris och hAi??g kvalitet :: InkAi??p Flagyl 200 mg LA?gt Pris :: Snabb leverans | RealUnifi.com
The Interface of Kai Krauses Software @mprove
The Interface of Kai Krauses Software @mprove
Increased KAI1 levels in AICD transgenic mice. (A) The | Open-i
KAI 1455 - AdisInsight
Kai Xin Transplanted 1 Year (YEAH...)
Athens Macedonian News Agency: News in Greek, 12-09-03
Kai Archives - Swoletron
CD82 gene - Genetics Home Reference - NIH
plu3223 - Uncharacterized protein - Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) - plu3223...
With Eyes Closed - MusicWave.gr | Face your music!
Honua Kai | BIG 1st Floor lawn~Konea 142 ~1... - VRBO
Kai on Etsy
Never Settled - Embracing Small Steps
SOL Search
Kraujolaboratorija.lt - CentoMetabolic
Zeamarine names Kai von Taube as director | JOC.com
lelmiszervizsg lati K zlem nyek 2012
Murah Meriah, GeNose Sudah Dipakai 63.000 Penumpang - khabarberita.com
Svorio netekimas gfr - autorenter.lt
Acta Pædiatrica: Ingenta Connect Table Of Contents
Free Healing Our World The Other Piece Of The Puzzle
Apie mus
Parkett No.75 2006
Prof. Jonas Grigas. Mobilūs telefonai ir smegenų vėžys - e-smogas
tyrimų kainos
Mycotaxon: Ingenta Connect Table Of Contents
Autoliike Seinäjoen Autot Myy Oy - Käytettyjen autojen erikoisliike Seinäjoella
CD81
1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the ... The tetraspanin family includes CD9, CD37, CD53, CD63, CD81 (this protein), CD82 and CD151. CD81 interacts directly with ... HIV gag proteins use tetraspanin enriched microdomains (containing minimally CD81, CD82, CD63) as a platform for virion ...
CD19
... amplifying the response of low affinity BCRs to low concentrations of antigen. CD19 has been shown to interact with: CD81 CD82 ... Mouse CD Antigen Chart Human CD Antigen Chart Human CD19 genome location and CD19 gene details page in the UCSC Genome Browser ... B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell ... Recognition of an antigen by the complement system enables the CD19/CD21 complex and associated intracellular signaling ...
CD82 (gene)
November 1992). "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced ... CD82+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD82 genome location and CD82 ... CD82 (gene) has been shown to interact with CD19, CD63 and CD234. CD82 plays a key role in the development of endometriosis. ... CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene. This metastasis suppressor gene ...
Duffy antigen system
The protein is also known to interact with the protein KAI1 (CD82) a surface glycoprotein of leukocytes and may have a role in ... The Fy4 antigen, originally described on Fy (a-b-) RBCs, is now thought to be a distinct, unrelated antigen and is no longer ... Because the Duffy antigen is uncommon in those of Black African descent, the presence of this antigen has been used to detect ... This antigen along with other blood group antigens was used to identify the Basque people as a genetically separate group. Its ...
Integrin alpha 4
CD49d+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA4 Info with links in the Cell ... Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules ...
CD20
B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and ... and CD82) at the surface of a B cell line JY". Journal of Immunology. 157 (7): 2939-46. PMID 8816400. Kanzaki M, Lindorfer MA, ... CD20+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) representations of the shape are found here ... Stamenkovic I, Seed B (June 1988). "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III ...
CD63
... antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of ... Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of ... Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional ... Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC (February 1991). "CD63 antigen. A novel lysosomal ...
CD53
1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". ... 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the ... Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. The protein encoded by this gene is a ... A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322-5. PMID 2258620. Dianzani U, ...
CD9
... and CD82". The Journal of Biological Chemistry. 273 (46): 30537-43. doi:10.1074/jbc.273.46.30537. PMID 9804823. Charrin S, Le ... "Molecular cloning of the CD9 antigen. A new family of cell surface proteins". The Journal of Biological Chemistry. 266 (1): 117 ... "Molecular cloning of the mouse equivalent of CD9 antigen". Thrombosis Research. 71 (5): 377-83. doi:10.1016/0049-3848(93)90162- ... "Purification and partial characterization of CD9 antigen of human platelets". FEBS Letters. 264 (2): 270-4. doi:10.1016/0014- ...
Complement receptor 2
... because CR2 binds to opsonized antigens through attached C3d (or iC3b or C3dg) when the B-cell receptor binds antigen. This ... and CD82". J. Biol. Chem. 273 (46): 30537-43. doi:10.1074/jbc.273.46.30537. PMID 9804823. Abbas AK, Lichtman AH (2003). ... results in the B cell having greatly enhanced response to the antigen. Epstein-Barr virus (EBV) can bind CR2, enabling EBV to ...
ATP1B3 - Википедия
Tissue Antigens (англ.)русск. : journal. - 2007. - Vol. 68, no. 6. - P. 509-517. - DOI:10.1111/j.1399-0039.2006.00726.x. - PMID ...
CD97 - Википедија, слободна енциклопедија
CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 ... 2001). „Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
CD117 - Википедија, слободна енциклопедија
CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 ... 1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID ... 2003). „Signal transduction-associated and cell activation-linked antigens expressed in human mast cells". Int. J. Hematol. 75 ...
Basigin
1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... 1992). "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse ... Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H (1992). "Human leukocyte activation antigen M6, a ... Ok blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ...
Меланотрансферрин - Википедия
Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same ... Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. (англ.) // Hum. ... Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3 ... Rose T. M., Plowman G. D., Teplow D. B., etal. Primary structure of the human melanoma-associated antigen p97 ( ...
CD74 - Википедия
CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens-associated invariant chainIa antigen ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ... Machamer C.E., Cresswell P. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens (англ.) // ...
C5a receptor
CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ...
CD4
... is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The ... Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, ... T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for antigens presented by MHC II and ... CD1+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ...
CD8
In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell antigen interactions. ... This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen- ... Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex ...
CLEC12A - Википедия
van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ...
CD44
In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.[5] CD44 has been referred to as HCAM (homing cell ... The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. ... Indian blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ... "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in ...
LAG3
A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... antigen processing and presentation of exogenous peptide antigen via MHC class II. ... antigen binding. • transmembrane signaling receptor activity. • MHC class II protein binding. Cellular component. • membrane. • ...
CEACAM5
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5. External IDs. HomoloGene: 128801 GeneCards: ... Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". ...
CXCR5 - Википедия
... uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate (англ.) // Blood (англ ...
CD15
It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ... CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 ...
CD154
B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In ... Grewal, IS; Xu, J; Flavell, RA (7 December 1995). "Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand". ...
CD30
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... results from cDNA cloning and sequence comparison of the CD30 antigen from different sources". Molecular Immunology. 31 (17): ...
CD97
Eichler W, Hamann J, Aust G (Nov 1997). "Expression characteristics of the human CD97 antigen". Tissue Antigens. 50 (5): 429-38 ... Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP (Apr 1999). "Expression of the activation antigen CD97 and ... Tissue Antigens. 57 (4): 325-31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941.. ... "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
Integrin beta 3
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ... CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
ABCG2
The protein also carries the Jr(a) antigen, which defines the Junior blood group system.[9] ...
Faktor aktivacije B-ćelija
CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin ...
P-selectin
Macrophage-1 antigen (CD11b+CD18). *VLA-4 (CD49d+CD29). *Glycoprotein IIb/IIIa (ITGA2B+ITGB3) ...
CDH1 (gene)
"Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin". Molecular and ...
C-C chemokine receptor type 6
Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes ... This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may ... dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens". J. Immunol. 167 (11): ...
CD97
CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 ... CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
Dipeptidyl peptidase-4
"Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ...
CD36 - Википедия
antigen processing and presentation of peptide antigen via MHC class I. • antigen processing and presentation of exogenous ... antigen processing and presentation of exogenous peptide antigen via MHC class I. • lipoprotein transport. • negative ... peptide antigen via MHC class I, TAP-dependent. • platelet degranulation. • MyD88-dependent toll-like receptor signaling ...
VCAM-1
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
SLAMF1
antigen binding. • virus receptor activity. • protein binding. • transmembrane signaling receptor activity. • identical protein ...
Duffy antigen system
The protein is also known to interact with the protein KAI1 (CD82) a surface glycoprotein of leukocytes and may have a role in ... This antigen along with other blood group antigens was used to identify the Basque people as a genetically separate group.[49] ... Because the Duffy antigen is uncommon in those of Black African descent, the presence of this antigen has been used to detect ... The Fy4 antigen, originally described on Fy (a-b-) RBCs, is now thought to be a distinct, unrelated antigen and is no longer ...
ICAM-1 - Википедия
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. • T cell antigen ... CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91 · CD92 · CD93 · CD94 · CD95 · CD96 · ...
CD64 (biology)
CD64+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Antigens, CD82 - Medical Dictionary online-medical-dictionary.org
anti-CD82 antibody | Rabbit anti-Mouse CD82 antigen Polyclonal Antibody-NP 001129527.1
Rabbit anti-Mouse CD82 antigen Polyclonal Antibody-NP_001129527.1 (MBS1488866) product datasheet at MyBioSource, Primary ... anti-CD82 antibody :: Rabbit anti-Mouse CD82 antigen Polyclonal Antibody. Catalog #. MBS1488866 .mycenter { display: block; ... Rabbit anti-mouse CD82 antigen polyclonal Antibody. Product Synonym Names C33 antigen; IA4; Inducible membrane protein R2; ... CD82 antigen UniProt Synonym Protein Names C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1 ...
Browsing by Keywords "CD82 antigen"
CD82 Gene - GeneCards | CD82 Protein | CD82 Antibody
CD82 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... CD82 Antigen 2 3 4 * Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected ... Protein details for CD82 Gene (UniProtKB/Swiss-Prot). Protein Symbol:. P27701-CD82_HUMAN. Recommended name:. CD82 antigen ... GeneCards Summary for CD82 Gene CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include Prostate ...
Anti-CD82 antibody (GTX31310) | GeneTex
Rabbit Polyclonal CD82 antibody. Validated in WB, IHC-P, ELISA. Tested in Human, Mouse, Rat. - professional antibody ... Antigen Species Human Immunogen CD82 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy ... Cd82 Molecule,4F9,C33,Gr15,Ia4,Kai1,R2,Sar2,St6,Tspan27,Cd82 ... WB analysis of A549 cell lysate using GTX31310 CD82 antibody. ... IHC-P analysis of human colon tissue using GTX31310 CD82 antibody. Working concentration : 2.5 μg/ml. ...
The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein
Tetraspanins such as CD82 contain two extracellular loops with its N terminus, C terminus, and inner loop exposed to the ... Antigens, CD / chemistry* * Antigens, CD / genetics * Antigens, CD / physiology* * Cell Line * Gene Products, gag / metabolism ... The cytoplasmic N terminus and C terminus of CD82 were also dispensable for CD82-MA interactions. In contrast, mutations of ... Tetraspanins such as CD82 contain two extracellular loops with its N terminus, C terminus, and inner loop exposed to the ...
Protein Links for PubMed (Select 1401919) - Protein - NCBI
Proteomics Analysis of Cells in Whole Saliva from Oral Cancer Patients via Value-added Three-dimensional Peptide Fractionation...
CD82 CD82 antigen (3/9). Multipass membrane protein. Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/ ... Lymphocyte antigen Ly-6D (1/19). Cell membrane; lipid anchor; GPI anchor. May be involved in cell-cell adhesion and signal ... 4F2 cell surface antigen heavy chain (4/9). Single pass type II membrane protein. Involved in sodium-independent, high affinity ... CD9 antigen (4/56). Multipass membrane protein. Involved in platelet activation and aggregation. Involved in cell adhesion, ...
Anti-CD82 antibody [C33] (Allophycocyanin) (ab205506) | Abcam
Mouse monoclonal CD82 antibody [C33] conjugated to APC. Validated in Flow Cyt and tested in Human. Immunogen corresponding to ... Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and ... Tissue, cells or virus corresponding to Human CD82. C91/PL (Human HTLV-1+ T cell line). ...
Anti-CD82 antibody - C-terminal (ab135779) | Abcam
Rabbit polyclonal CD82 antibody validated for WB, IHC, Flow Cyt and tested in Human and Mouse. Immunogen corresponding to ... Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and ... Anti-CD82 antibody - C-terminal (ab135779) at 1/100 dilution + Mouse liver lysate at 12.5 µg. Predicted band size: 29 kDa. ... Lane 2 : 293 cell lysates, transiently transfected with the CD82 gene Lysates/proteins at 2 µg per lane.. Predicted band size: ...
Anti-CD82 Antibodies | Invitrogen
...
22 antibodies to CD82 and validated for use in 6 applications (Immunohistochemistry,Flow Cytometry,Western Blot, ... C33 antigen; CD82; CD82 antigen; IA4; Inducible membrane protein R2; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 ... antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); Metastasis suppressor Kangai-1; Suppressor of ... CD82 Antibodies This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 ...
KEGG BRITE: Exosome - Mus musculus (mouse)
12505 Cd44; CD44 antigen 12508 Cd53; CD53 antigen 12509 Cd59a; CD59a antigen 333883 Cd59b; CD59b antigen 12521 Cd82; CD82 ... CD44 antigen K06489 CD53; CD53 antigen K04008 CD59; CD59 antigen K04008 CD59; CD59 antigen K06509 KAI1; CD82 antigen K05413 ... MHC class II antigen K06752 MHC2; MHC class II antigen K06752 MHC2; MHC class II antigen K06752 MHC2; MHC class II antigen ... MHC class II antigen K06752 MHC2; MHC class II antigen K06752 MHC2; MHC class II antigen K06752 MHC2; MHC class II antigen ...
CD82 (CD82 molecule)
CD82 molecule), Authors: Yanhui H Zhang, Mekel M Richardson, Feng Zhang, Xin A Zhang. Published in: Atlas Genet Cytogenet Oncol ... kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and ... ACSL1--CD82 CD82--ACADVL CD82--ANP32A CD82--BCL6 CD82--CD44 CD82--COLEC12 CD82--G3BP2 CD82--LINC00338 CD82--LYZ CD82--PHF21A ... CD82--POLR2E CD82--SYNJ2BP-COX16 CD82--TAPBP CD82--UVRAG DTNA--CD82 ERBB2--CD82 LAPTM5--CD82 LYZ--CD82 PICALM--CD82 PIGR--CD82 ...
CD82 (human)
Names/Synonyms: 4F9; C33; C33 antigen; CD82; CD82 antigen; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal ... CD82 a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be ... R2 leukocyte antigen; SAR2; ST6; suppression of tumorigenicity 6; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan ... and antibody IA4)); CD82 molecule; GR15; IA4; Inducible membrane protein R2; KAI1; kangai 1 (suppression of tumorigenicity 6, ...
CD82 (CD82 molecule)
CD82 molecule), Authors: Yanhui H Zhang, Mekel M Richardson, Feng Zhang, Xin A Zhang. Published in: Atlas Genet Cytogenet Oncol ... kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and ... CD82 Mutations. ICGC Data Portal. CD82 TCGA Data Portal. CD82 Broad Tumor Portal. CD82. OASIS Portal. CD82 [ Somatic mutations ... CD82 [ NCBI-GEO ] CD82 [ EBI - ARRAY_EXPRESS ] CD82 [ SEEK ] CD82 [ MEM ] Gene Expression Viewer (FireBrowse). CD82 [ ...
CD82 Antibody, anti-human, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec - Schweiz
... components of the antigen-processing and presentation pathway and tetraspanin CD63, in dendritic cells. Expression of CD82 is ... On the surface of tumor cells, CD82 interacts with integrins and is suggested to serve as a supressor of tumor metastasis. In ... CD82 interacts with other tretaspanins and membrane proteins, thus regulating several functions such as signal transduction. ... addition, on immune cells such as T cells, CD82 associates with CD81, CD4, or CD8 and class II major histocompatibility complex ...
CD1.1 antigen Antibody (CB3) (NBP1-28362): Novus Biologicals
Mouse Monoclonal Anti-CD1.1 antigen Antibody (CB3). Validated: Flow, IHC, IHC-Fr, IP, ICC. Tested Reactivity: Chicken. 100% ... Blogs on CD1.1 antigen. There are no specific blogs for CD1.1 antigen, but you can read our latest blog posts. ... Diseases for CD1.1 antigen Antibody (NBP1-28362). Discover more about diseases related to CD1.1 antigen Antibody (NBP1-28362). ... Reviews for CD1.1 antigen Antibody (NBP1-28362) (0) There are no reviews for CD1.1 antigen Antibody (NBP1-28362). By submitting ...
Anti-CD82 Antibody | Rabbit anti-Human Polyclonal WB | LSBio
CD82 antibody LS-C169739 is an unconjugated rabbit polyclonal antibody to CD82 (aa98-147) from human. It is reactive with human ... R2 leukocyte antigen , SAR2 , ST6 , Tetraspanin-27 , Tspan-27 , TSPAN27 , CD82 antigen , Leukocyte surface antigen r2 , ... CD82 , 4F9 , C33 , C33 antigen , CD82 molecule , GR15 , IA4 , Inducible membrane protein R2 , KAI1 , Kangai 1 , R2 , ... Polyclonal Rabbit anti‑Human CD82 Antibody (aa98‑147, WB) LS‑C169739 Polyclonal Rabbit anti‑Human CD82 Antibody (aa98‑147, WB) ...
US20180064935A1 - Bioelectric stimulator
- Google Patents
KEGG BRITE: KEGG Orthology (KO) - Vulpes vulpes (red fox)
112924116 CD82; CD82 antigen 112919933 THBS1; thrombospondin-1 112919310 SERPINB5; serpin B5 isoform X1 112924073 DDB2; DNA ... CD82 antigen K16857 THBS1; thrombospondin 1 K10139 SERPINB5; serpin B5 K10140 DDB2; DNA damage-binding protein 2 K10808 RRM2; ... 112924853 TP53; cellular tumor antigen p53 112922285 MDM2; E3 ubiquitin-protein ligase Mdm2 112914392 MDM4; protein Mdm4 ... 112924853 TP53; cellular tumor antigen p53 112913942 CDKN1A; cyclin-dependent kinase inhibitor 1 112924157 CCND1; G1/S-specific ...
KEGG BRITE: KEGG Orthology (KO) - Columba livia (rock pigeon)
102085372 CD82; CD82 antigen 102091738 THBS1; LOW QUALITY PROTEIN: thrombospondin-1 102093220 SERPINB5; serpin B5 102087151 ... CD82 antigen K16857 THBS1; thrombospondin 1 K10139 SERPINB5; serpin B5 K10140 DDB2; DNA damage-binding protein 2 K10808 RRM2; ... 102083685 antigen-presenting glycoprotein CD1d isoform X2 102084043 T-cell surface glycoprotein CD1b-3 106145650 T-cell surface ... 102087248 antigen-presenting glycoprotein CD1d 102083859 LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1b-1-like 102089481 ...
Bio-Connect
OriGene - Cd82 (NM 001136055) cDNA Clone
Cd82 (untagged) - Mouse CD82 antigen (Cd82), transcript variant 2, (10ug) available for purchase from OriGene - Your Gene ... Cd82 Rat Clones. SKU. Description. Price. Shipping. RN200770. Cd82 (untagged ORF) - Rat Cd82 molecule (Cd82), (10 ug). $390. 3 ... Cd82 Human Clones. SKU. Description. Price. Shipping. SC107926. CD82 (untagged)-Human CD82 molecule (CD82), transcript variant ... Cd82 (untagged) - Mouse CD82 antigen (Cd82), transcript variant 2, (10ug), NM_001136055.2, 10ug. $390. 4 weeks. ...
Anti-Hu CD82 APC - EXBIO Antibodies
Exbio - Research products - Antibodies - CD and related antigens - Anti-Hu CD82 APC ... Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T ... Flow cytometry analysis (surface staining) of CD82 on human peripheral blood cells with anti-CD82 (C33) APC. ... Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by ...
Pacific Blue anti-human CD81 TAPA-1 Antibody anti-CD81 - 5A6
Antigen Details Structure 26 kD, type III transmembrane protein, member of the TM4SF tetraspanin family. Complexed with CD82, ... Antigen References 1. Menno C, et al. 2010. J. Clin. Invest. 4:1265.. 2. Fearon D, et al. 1995. Annu. Rev. Immunol. 13:127.. 3 ... and CD82 in B cells, and CD4, CD8, and CD82 in T cells. ...
CD82 related Antibodies, Proteins, cDNA and ELISA Kits- Cusabio
Cusabio offers CD82 related Antibodies, Proteins, cDNA and ELISA Kits. We also illustrate the related signaling pathways ... Recombinant Mouse CD82 antigen(Cd82). in vitro E.coli expression system. CSB-EP004961MO. Recombinant Mouse CD82 antigen(Cd82) , ... CD82. CD82. CD82 antigen is a protein in humans that is encoded by CD82 gene. Associates with CD4 or CD8 and delivers ... Recombinant Rat CD82 antigen(Cd82). in vitro E.coli expression system. CSB-YP004961RA1. CSB-EP004961RA1. CSB-BP004961RA1. CSB- ...
Frontiers | Precise Delineation and Transcriptional Characterization of Bovine Blood Dendritic-Cell and Monocyte Subsets |...
The transcriptomic data also revealed differential gene transcription for molecules involved in antigen presentation, pathogen ... The transcriptomic data also revealed differential gene transcription for molecules involved in antigen presentation, pathogen ... In mice, the tetraspanins CD82 and CD37 have been described to be involved in migration and antigen presentation of DC (92). ... Dendritic cell migration and antigen presentation are coordinated by the opposing functions of the tetraspanins CD82 and CD37. ...
Frontiers | Regulatory Role of Immune Cell-Derived Extracellular Vesicles in Cancer: The Message Is in the Envelope | Immunology
EVs derived from antigen presenting cells (APCs) that are loaded with either peptide or whole protein antigens are reported to ... CD82, CD9, and CD63) (5, 26, 27). These proteins route various sEV cargoes by forming clusters with each other as well as with ... Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from professional antigen-presenting cells. Annu ... and cells that are devoid of MHC class I antigen expression. This innate killing activity is not governed by any antigen ...
CD81 - Wikipedia
1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the ... The tetraspanin family includes CD9, CD37, CD53, CD63, CD81 (this protein), CD82 and CD151. CD81 interacts directly with ... HIV gag proteins use tetraspanin enriched microdomains (containing minimally CD81, CD82, CD63) as a platform for virion ...
Antibody10
- Small volumes of anti-CD82 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
- CD82 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human CD82.The immunogen is located within the last 50 amino acids of CD82. (genetex.com)
- IHC-P analysis of human colon tissue using GTX31310 CD82 antibody. (genetex.com)
- WB analysis of A549 cell lysate using GTX31310 CD82 antibody. (genetex.com)
- There are currently no images for CD1.1 antigen Antibody (NBP1-28362). (novusbio.com)
- CD82 antibody LS-C169739 is an unconjugated rabbit polyclonal antibody to CD82 (aa98-147) from human. (lsbio.com)
- The mouse monoclonal antibody C33 recognizes an extracellular/luminal epitope of CD82, a widely expressed cell surface protein of the tetraspanin family. (exbio.cz)
- citation needed] In 1950, the Duffy antigen was discovered in a multiply-transfused hemophiliac whose serum contained the first example of anti-Fya antibody. (wikipedia.org)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
- The antibody MEM-53 reacts also with deglycosylated molecule (molecular weight of the antigen is reduced by 15 kDa using endoglycosidase F). (exbio.cz)
Molecule4
- CD82 (CD82 Molecule) is a Protein Coding gene. (genecards.org)
- Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD antigens molecule have been identified. (sinobiological.com)
- This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. (exbio.cz)
- The basic principle of tetramer staining requires that TCRs bind to the antigen-presenting molecule and that this physical interaction is mediated by a groove-bound cognate antigen that physically ligates CD1 to the TCR. (rupress.org)
Antibodies5
- Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. (exbio.cz)
- Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. (exbio.cz)
- The virus-containing vacuoles were also labeled with antibodies against LAMP-1, CD81, and CD82, which were also incorporated into the viral envelope. (rupress.org)
- Only antibodies against antigens found in late endosomes precipitated infectious virus, whereas antibodies against proteins located primarily on the cell surface did not. (rupress.org)
- CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies. (sinobiological.com)
CD639
- HIV gag proteins use tetraspanin enriched microdomains (containing minimally CD81, CD82, CD63) as a platform for virion assembly and release. (wikipedia.org)
- The vesicles derived from mammalian cells contain a family of integral membrane proteins that cross four times the lipid bilayer and are called tetraspanins [ 11 ], including the surface markers of lymphocytes and antigen-presenting cells such as CD37, CD9, CD53, CD63, CD81, and CD82. (hindawi.com)
- Here, we reveal the presence of tetraspanin-enriched microdomains (TEMs) containing the tetraspanins CD9, CD63, CD81, and CD82 at the plasma membrane. (rupress.org)
- CD63 has been shown to interact with CD117 [ 2 ] and CD82 . (thefullwiki.org)
- 1992). "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. (thefullwiki.org)
- The CD63 antigen, also known as lysosomal membrane associated glycoprotein 3 (LAMP3), is a member of the tetraspanin (TM4SF) family. (mybeckman.pl)
- CD63, as other tetraspanins (CD9, CD81, CD82), has recently been reported as forming complexes with VLA-3 and phosphatidylinositol 4-kinase, with VLA-6, CD11/CD18 and tyrosine kinase. (mybeckman.pl)
- CD63 has been found to be identical to the ME491 antigen expressed by melanoma cells. (mybeckman.pl)
- CD63 antigen, present in azurophilic granules of non-stimulated neutrophils, is strongly expressed on the surface of neutrophils after activation. (mybeckman.pl)
CD536
- It exists in a complex with MHC class I and II, CD53, CD81, and CD82. (biolegend.com)
- Yunta M, Rodríguez-Barbero A, Arévalo MA, López-Novoa JM, Lazo PA: Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. (exbio.cz)
- Yunta M, Lazo PA: Apoptosis protection and survival signal by the CD53 tetraspanin antigen. (exbio.cz)
- Mollinedo F, Martín-Martín B, Gajate C, Lazo PA: Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. (exbio.cz)
- Angelisova P, Vlcek C, Stefanova I, Lipoldova M, Horejsi V: The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (exbio.cz)
- Angelisova P, Hilgert I, Horejsi V. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. (springer.com)
Metastasis8
- In relation to cancer, CD82 function is to inhibit tumor invasion and suppresses tumor metastasis. (atlasgeneticsoncology.org)
- The metastasis-suppressive effect of CD82 can be observed in the animal studies of cancer metastasis by re-introducing CD82 expression in various metastatic cancer cell lines such as prostate cancer AT6.1, prostate cancer LNCaP, fibroblastoma HT1080, melanoma MDA-MB-435, breast cancer LCC6, liver cancer MHCC97-H, and lung cancer LLC lines. (atlasgeneticsoncology.org)
- The observations of CD82-mediated suppression of cancer metastasis in animal models are supported by a variety of clinical studies on the human cancers from prostate, breast, ovary, colon, lung, stomach, liver, and other organs. (atlasgeneticsoncology.org)
- Some are involved in oncogenesis and in the control of metastasis: CD9, CD81, CD82, C0/029, and CD151 can all modulate cancer cell motility both in vitro and in vivo (reviewed in references 5 and 49). (asm.org)
- To investigate the relationship of KAI1/CD82, CD44, matrix metalloproteinase 7 (MMP7) and β-catenin, and examine its association with clinicopathological features, metastasis and prognosis in colorectal carcinoma (CRC). (biomedcentral.com)
- However, decreased KAI1/CD82 expression correlated significantly with distant metastasis, lymph node metastasis and TNM stage. (biomedcentral.com)
- Multivariate logistic regression analysis showed that KAI1/CD82 and β-catenin expression were significantly associated with lymph node metastasis and KAI1/CD82 was significantly associated with distant metastasis. (biomedcentral.com)
- The expression of KAI1/CD82, CD44, MMP7 and β-catenin is related to tumor metastasis and prognosis in CRC. (biomedcentral.com)
Gene9
- NCBI/Uniprot data below describe general gene information for CD82 . (mybiosource.com)
- GA733 tumor-associated antigen gene family may function as growth factor receptors. (mcponline.org)
- Currently there is no report for the disease-related or biologically significant mutation for CD82 gene ( See HGMD ). (atlasgeneticsoncology.org)
- CD82 antigen is a protein in humans that is encoded by CD82 gene. (cusabio.com)
- The transcriptomic data also revealed differential gene transcription for molecules involved in antigen presentation, pathogen sensing, and migration, and therefore gives insights into functional differences between bovine DC and monocyte subsets. (frontiersin.org)
- Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene. (wikipedia.org)
- The Duffy antigen gene was the fourth gene associated with the resistance after the genes responsible for sickle cell anaemia, thalassemia and glucose-6-phosphate dehydrogenase. (wikipedia.org)
- The gene was first localised to chromosome 1 in 1968, and was the first blood system antigen to be localised. (wikipedia.org)
- Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant transformation. (thefullwiki.org)
Tetraspanins4
- Tetraspanins such as CD82 contain two extracellular loops with its N terminus, C terminus, and inner loop exposed to the cytoplasm. (nih.gov)
- CD82 associates with other transmembrane proteins such as tetraspanins, integrins, Ig superfamily members, and growth factor receptors and intracellular signaling proteins to regulate membrane microdomain organization, vesicular trafficking, and transmembrane signaling. (atlasgeneticsoncology.org)
- The tetraspanins Cd9 , Cd81 , and Cd82 were also associated with the late, sustained response. (pubmedcentralcanada.ca)
- Tetraspanins form multimolecular complexes with each other and with other membrane proteins, including integrins, major histocompatibility complex antigens, signaling complexes, and cell-associated growth factors. (asm.org)
Differentiation4
- The CD antigens / Cluster of differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. (sinobiological.com)
- We surmised that CD82 are participates in trophoblast differentiation during placenta development. (jove.com)
- Non-peptide antigen presentation to T-cell receptors on NKT cells, marks T-cells at the short cortical thymic stage of differentiation. (abcam.co.jp)
- Brackman D, Lund-Johansen F, Aarskog D. Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3: comparison with the maturation of normal monocytic and granulocytic bone marrow cells. (springer.com)
Glycoprotein2
- CD82 is a 4-transmembrane glycoprotein and belongs to the tetraspanin superfamily. (atlasgeneticsoncology.org)
- A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. (thefullwiki.org)
CD81 and CD822
Polyclonal1
- Polyclonal T cells from patients sorted with tetramers are activated by GMM antigens presented by CD1b. (rupress.org)
Signal transduction1
- The KAI1/CD82 protein is a member of the TM4SF (transmembrane 4 superfamily), which mediates signal transduction both between cells and between cells and the extracellular matrix (ECM) [ 6 ]. (biomedcentral.com)
P277011
- Synthetic peptide located between aa98-147 of human CD82 (P27701, NP_001020015). (lsbio.com)
Tumor6
- CD82 expression is frequently diminished or lost in invasive and metastatic solid-tumor tissues. (atlasgeneticsoncology.org)
- EVs derived from antigen presenting cells (APCs) that are loaded with either peptide or whole protein antigens are reported to induce anti-tumor immunity in animal models but show only modest improvements in cancer patients ( 2 , 7 - 9 ). (frontiersin.org)
- These observations support the proposal that nano-sized EVs can be used as carriers to deliver soluble antigens in tumor models ( 10 ). (frontiersin.org)
- CD antigens are used widely for research, immunotherary, tumor and drug target. (sinobiological.com)
- CD82 is a member of transmembrane 4 superfamily, which showed important role in inhibiting tumor cell invasion and migration. (jove.com)
- 1988). "Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. (thefullwiki.org)
Molecules3
- CD1 molecules, like MHC I and II, play an equally important role in the immune system by presenting lipid, glycolipid and lipopeptide antigen to T and NKT cells. (novusbio.com)
- The CD antigens are protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. (sinobiological.com)
- Like most mammalian species, humans express several structurally distinct CD1 antigen-presenting molecules. (rupress.org)
Proteins2
- Because of the glycosylation, the molecular weight of CD82 proteins ranges between 30-90 kDa depending on tissue and cell types. (atlasgeneticsoncology.org)
- Germline deletion of group 1 proteins is not currently feasible, so development of CD1 tetramers represents a promising method to study fresh antigen-specific T cells at the population level. (rupress.org)
Amino acids3
- In contrast, mutations of conserved amino acids in the inner loop of CD82 or of palmitoylated cysteines that flank the inner loop diminished CD82 association with MA. (nih.gov)
- Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 238-267 of Human CD82. (abcam.com)
- 2003). In this variant, the 84bp exon that encodes the amino acids 215-242 of CD82/kAI1 protein is selectively deleted. (atlasgeneticsoncology.org)
Peptide3
- Non peptide antigen presentation to T-cell receptors on NKT cells. (sinobiological.com)
- Non peptide antigen presentation. (abcam.co.jp)
- Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. (genetex.com)
Extracellular2
- The large extracellular loop of CD82, which is important for interactions with integrins, was not required for the association with HTLV-1 MA. (nih.gov)
- CD82 undergoes two types of post-translational modifications: glycosylation at its large extracellular loop and palmitoylation at the cysteine residues in or near cytoplasmic domains. (atlasgeneticsoncology.org)
Clone1
- Wild type (red) and knockout cells (blue) were stained with CD82-PE, clone (REA221). (miltenyibiotec.com)
Receptors1
- Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. (rupress.org)
Surface2
- Flow cytometry analysis (surface staining) of CD82 on human peripheral blood cells with anti-CD82 (C33) APC. (exbio.cz)
- The Duffy antigen is located on the surface of red blood cells, and is named after the patient in whom it was discovered. (wikipedia.org)
Transmembrane domains1
- Palmitoylation is essential for CD82 function as well as the presence of three polar residues, NQE, located within its transmembrane domains. (atlasgeneticsoncology.org)
Chemokine receptor1
- the Duffy Antigen Chemokine Receptor, or DARC, on endothelial cells. (coursera.org)
Tetraspanin antigen2
- Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression. (springer.com)
- Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines. (springer.com)
CD444
- Immunohistochemical (IHC) analysis was used to detect the expression of KAI1/CD82, CD44, MMP7 and β-catenin in 174 archival surgical specimens of human CRC. (biomedcentral.com)
- KAI1/CD82 expression showed a negative correlation with CD44, MMP7 and β-catenin. (biomedcentral.com)
- Kaplan-Meier analysis revealed that CD44, MMP7 and β-catenin expression was negatively correlated with overall survival (OS), while KAI1/CD82 expression was positively correlated with OS. (biomedcentral.com)
- Low KAI1/CD82 expression and high expression of CD44, MMP7 and β-catenin was associated with a poor prognosis in CRC. (biomedcentral.com)
MeSH1
- Antigens, CD14" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
HUMAN3
- Tissue, cells or virus corresponding to Human CD82. (abcam.com)
- CD82 is ubiquitously expressed in various human tissues such as epithelium and endothelium. (atlasgeneticsoncology.org)
- miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells. (genetex.com)
CDNA1
- The cDNA encoding the corresponding antigen was cloned from megakaryoblastic leukemia cells and shown to be a member of the transmembrane 4 or tetraspanin family ( 10 ). (asm.org)