Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. (1/333)
The tetraspans are molecules with four transmembrane domains which are engaged in multimolecular complexes (the tetraspan web) containing a subset of beta1 integrins (in particular alpha3beta1, alpha4beta1 and alpha6beta1), MHC antigens and several unidentified molecules. The molecules associated with tetraspans are readily detected after immunoprecipitation performed in mild detergents such as Brij 97 or CHAPS. In this study we show that another classical mild detergent, digitonin, dissociated most of these associated molecules, including integrins, from the tetraspans CD9, CD37, CD53, CD63, CD82, Co-029, Talla-1 and NAG-2. In contrast, reciprocal immunoprecipitations from various cell lines demonstrated that two other tetraspans, CD81 and CD151, formed complexes with integrins not disrupted by digitonin. These complexes were CD81/alpha4beta1, CD151/alpha3beta1 and CD151/alpha6beta1. Furthermore, a new anti-CD151 monoclonal antibody (mAb), TS151r, was shown to have a restricted pattern of expression, inversely related to the sum of the levels of expression of alpha6beta1 and alpha3beta1. This mAb was unable to co-precipitate integrins in digitonin, suggesting that its epitope is blocked by the association with integrins. Indeed, the binding of TS151r to the cell surface was quantitatively diminished following alpha3beta1 overexpression. Altogether, these data suggest that, among tetraspans, CD81 interacts directly with the integrin alpha4beta1, and CD151 interacts directly with integrins alpha3beta1 and alpha6beta1. Because all tetraspan-tetraspan associations are disrupted by digitonin, it is likely that the other tetraspans interact indirectly with integrins, through interactions with CD81 or CD151. (+info)Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. (2/333)
A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds specifically to the surface of cells expressing human CD81 (hCD81) but not other members of the tetraspanin family (CD9, CD63, and CD151). No differences were noted between the level of E2661 binding to hCD81 expressed on the surface of rat RBL or KM3 cells compared to Daudi and Molt-4 cells, suggesting that additional human-cell-specific factors are not required for the primary interaction of E2 with the cell surface. E2 did not interact with African green monkey (AGM) CD81 on the surface of COS cells, which differs from the hCD81 sequence at four residues within the second extracellular region (EC2) (amino acids [aa] 163, 186, 188, and 196), suggesting that one or more of these residues defines the site of interaction with E2. Various recombinant forms of CD81 EC2 show differences in the ability to bind E2, suggesting that CD81 conformation is important for E2 recognition. Regions of E2 involved in the CD81 interaction were analyzed, and our data suggest that the binding site is of a conformational nature involving aa 480 to 493 and 544 to 551 within the E2 glycoprotein. Finally, we demonstrate that ligation of CD81 by E2661 induced aggregation of lymphoid cells and inhibited B-cell proliferation, demonstrating that E2 interaction with CD81 can modulate cell function. (+info)Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein. (3/333)
Hepatitis C virus (HCV) glycoproteins E1 and E2, when expressed in eukaryotic cells, are retained in the endoplasmic reticulum (ER). C-terminal truncation of E2 at residue 661 or 715 (position on the polyprotein) leads to secretion, consistent with deletion of a proposed hydrophobic transmembrane anchor sequence. We demonstrate cell surface expression of a chimeric glycoprotein consisting of E2 residues 384 to 661 fused to the transmembrane and cytoplasmic domains of influenza A virus hemagglutinin (HA), termed E2661-HATMCT. The E2661-HATMCT chimeric glycoprotein was able to bind a number of conformation-dependent monoclonal antibodies and a recombinant soluble form of CD81, suggesting that it was folded in a manner comparable to "native" E2. Furthermore, cell surface-expressed E2661-HATMCT demonstrated pH-dependent changes in antigen conformation, consistent with an acid-mediated fusion mechanism. However, E2661-HATMCT was unable to induce cell fusion of CD81-positive HEK cells after neutral- or low-pH treatment. We propose that a stretch of conserved, hydrophobic amino acids within the E1 glycoprotein, displaying similarities to flavivirus and paramyxovirus fusion peptides, may constitute the HCV fusion peptide. We demonstrate that influenza virus can incorporate E2661-HATMCT into particles and discuss experiments to address the relevance of the E2-CD81 interaction for HCV attachment and entry. (+info)Finding the right RNA: identification of cellular mRNA substrates for RNA-binding proteins. (4/333)
Defects in RNA-binding proteins have been implicated in human genetic disorders. However, efforts in understanding the functions of these proteins have been hampered by the inability to obtain their mRNA substrates. To identify cognate cellular mRNAs associated with an RNA-binding protein, we devised a strategy termed isolation of specific nucleic acids associated with proteins (SNAAP). The SNAAP technique allows isolation and subsequent identification of these mRNAs. To assess the validity of this approach, we utilized cellular mRNA and protein from K562 cells and alphaCP1, a protein implicated in a-globin mRNA stability, as a model system. Immobilization of an RNA-binding protein with the glutathione-S-transferase (GST) domain enables isolation of mRNA within an mRNP context and the identity of the bound mRNAs is determined by the differential display assay. The specificity of protein-RNA interactions was considerably enhanced when the interactions were carried out in the presence of cellular extract rather than purified components. Two of the mRNAs specifically bound by alphaCP1 were mRNAs encoding the transmembrane receptor protein, TAPA-1, and the mitochondrial cytochrome c oxidase subunit II enzyme, coxII. A specific poly(C)-sensitive complex formed on the TAPA-1 and coxII 3' UTRs consistent with the binding of aCP1. Furthermore, direct binding of purified alphaCP proteins to these 3' UTRs was demonstrated and the binding sites determined. These results support the feasibility of the SNAAP technique and suggest a broad applicability for the approach in identifying mRNA targets for clinically relevant RNA-binding proteins that will provide insights into their possible functions. (+info)Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. (5/333)
The role of transmembrane 4 superfamily (TM4SF) proteins during muscle cell fusion has not been investigated previously. Here we show that the appearance of TM4SF protein, CD9, and the formation of CD9-beta1 integrin complexes were both regulated in coordination with murine C2C12 myoblast cell differentiation. Also, anti-CD9 and anti-CD81 monoclonal antibodies substantially inhibited and delayed conversion of C2C12 cells to elongated myotubes, without affecting muscle-specific protein expression. Studies of the human myoblast-derived RD sarcoma cell line further demonstrated that TM4SF proteins have a role during muscle cell fusion. Ectopic expression of CD9 caused a four- to eightfold increase in RD cell syncytia formation, whereas anti-CD9 and anti-CD81 antibodies markedly delayed RD syncytia formation. Finally, anti-CD9 and anti-CD81 monoclonal antibodies triggered apoptotic degeneration of C2C12 cell myotubes after they were formed. In summary, TM4SF proteins such as CD9 and CD81 appear to promote muscle cell fusion and support myotube maintenance. (+info)Rapid and systemic accumulation of chloroplast mRNA-binding protein transcripts after flame stimulus in tomato. (6/333)
It has been shown that tomato (Lycopersicon esculentum) plants respond to flame wounding and electrical stimulation by a rapid (15 min) and systemic up-regulation of proteinase inhibitor (pin) genes. To find other genes having a similar expression pattern, we used subtractive cDNA screening between flamed and control plants to select clones up-regulated by flame wounding. We report the characterization of one of them, a chloroplast mRNA-binding protein encoded by a single gene and expressed preferentially in the leaves. Systemic gene expression in response to flaming in the youngest terminal leaf exhibited three distinct phases: a rapid and transient increase (5-15 min) in transcript accumulation, a decline to basal levels (15-45 min), and then a second, more prolonged increase (60-90 min). In contrast, after a mechanical wound the rapid, transient increase (5 min) was followed by a rapid decline to basal levels but no later, prolonged accumulation. In the petiole, the initial flame-wound-evoked transient increase (15 min) was followed by a continuous decline for 3 h. The nature of the wound signal(s) causing such rapid changes in transcript abundance is discussed in relation to electrical signaling, which has recently been implicated in plant responses to wounding. (+info)Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association. (7/333)
CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are required for the association. Immunoprecipitation of T cell lysates with anti-CD9 mAb followed by immunoblotting with mAb against various T cell molecules showed the association of CD9 with CD3, CD4, CD5, CD2, CD29 and CD44. Because association with CD5 was most prominent, we determined the role of CD9 TM or extracellular (EC) domains in the association with CD5. CD9 mutant genes lacking each domain were constructed and introduced into EL4 thymoma cells deficient in CD9 but expressing CD5. Among various types of stable EL4 transfectants, EL4 transfected with the mutant gene lacking TM domains (TM2/TM3) between two EC domains expressed a small amount of the relevant protein without showing association with CD5. CD9(-)CD5(-) monkey COS-7 cells transfected with this mutant gene and the CD5 gene expressed both transfected gene products, but the association of these was not detected. EL4 cells transfected with a CD9/CD81 chimera gene (the CD9 gene containing TM2/TM3 of CD81) expressed the chimeric protein on the cell surface and showed association with CD5. These results suggest an essential role of particular CD9 TM domains in the surface expression of the CD9 molecule as well as the association with CD5. (+info)Functional characterization of intracellular and secreted forms of a truncated hepatitis C virus E2 glycoprotein. (8/333)
The E2 protein of hepatitis C virus (HCV) is believed to be a virion surface glycoprotein that is a candidate for inclusion in an antiviral vaccine. A truncated soluble version of E2 has recently been shown to interact with CD81, suggesting that this protein may be a component of the receptor for HCV. When expressed in eukaryotic cells, a significant proportion of E2 forms misfolded aggregates. To analyze the specificity of interaction between E2 and CD81, the aggregated and monomeric forms of a truncated E2 glycoprotein (E2(661)) were separated by high-pressure liquid chromatography and analyzed for CD81 binding. Nonaggregated forms of E2 preferentially bound CD81 and a number of conformation-dependent monoclonal antibodies (MAbs). Furthermore, intracellular forms of E2(661) were found to bind CD81 with greater affinity than the extracellular forms. Intracellular and secreted forms of E2(661) were also found to differ in reactivity with MAbs and human sera, consistent with differences in antigenicity. Together, these data indicate that proper folding of E2 is important for its interaction with CD81 and that modifications of glycans can modulate this interaction. Identification of the biologically active forms of E2 will assist in the future design of vaccines to protect against HCV infection. (+info)Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity. - Oxford...
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Co-stimulation
... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... CR2 on mature B cells forms a complex with CD19 and CD81. This complex is called the B cell coreceptor complex for such ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... Co-stimulation is a secondary signal which immune cells rely on to activate an immune response in the presence of an antigen- ...
CD81
1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... HCV-E2 and CD81 binding Kd is 1.8 nM. HCV-E2 engaged CD81 is only 30% internalized after 12hr, suggesting CD81 may be primarily ... CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. It ... CD81+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD81 genome location and CD81 ...
TSPAN4
This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known ... TSPAN4 has been shown to interact with CD9, ITGA6, CD29, CD49c and CD81. GRCh38: Ensembl release 89: ENSG00000214063 - Ensembl ... 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions ...
CD19
... amplifying the response of low affinity BCRs to low concentrations of antigen. CD19 has been shown to interact with: CD81 CD82 ... Mouse CD Antigen Chart Human CD Antigen Chart Human CD19 genome location and CD19 gene details page in the UCSC Genome Browser ... B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell ... CD81, attached to CD19, is a part of the tetraspanin web, acts as a chaperone protein, and provides docking sites for molecules ...
Sushi domain
IFC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and ... CD21 is part of a large signal-transduction complex that also involves CD19, CD81, and Leu13. Some of the proteins in this ... Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a ... Lomas-Francis, Christine; Reid, Marion E. (2004). The blood group antigen: factsbook. Boston: Academic Press. ISBN 0-12-586585- ...
B cell
... and signals are transduced through CD19 and CD81 to lower the activation threshold of the cell. Antigens that activate B cells ... Antigens that activate B cells without T cell help are known as T cell-independent (TI) antigens and include foreign ... As with TD antigens, B cells activated by TI antigens need additional signals to complete activation, but instead of receiving ... Upon antigen binding, the memory B cell takes up the antigen through receptor-mediated endocytosis, degrades it, and presents ...
Complement receptor 2
The CR2-CD19-CD81 complex is often called the B cell co-receptor complex, because CR2 binds to opsonized antigens through ... This results in the B cell having greatly enhanced response to the antigen. Epstein-Barr virus (EBV) can bind CR2, enabling EBV ... Complement receptor 2 interacts with CD19, and, on mature B cells, forms a complex with CD81 (TAPA-1). ... CD81, and the fragilis/Ifitm (murine equivalents of LEU13) proteins. The CR2 gene of primates produces only the smaller isoform ...
Outline of immunology
Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... Immunoglobulin light chain Co-receptors Stimulatory CD21 CD19 CD81 Inhibitory CD22 Accessory molecule (CD79) Ig-α (CD79A) Ig-β ... CD79B) T cells Antigen receptor - T cell receptor (TCR) Subunits - [email protected] / [email protected] / [email protected] / [email protected] Co-receptors CD8 (CD8α / CD8β) CD4 ... CD18 Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late ...
PI4KA
Carloni V, Mazzocca A, Ravichandran KS (2004). "Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor ... Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a ...
Integrin alpha 4
CD49d+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA4 Info with links in the Cell ... Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules ...
CD20
B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and ... CD81, and CD82) at the surface of a B cell line JY". Journal of Immunology. 157 (7): 2939-46. PMID 8816400. Kanzaki M, ... CD20+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) representations of the shape are found here ... Stamenkovic I, Seed B (June 1988). "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III ...
IBA Lifesciences
... and virus-derived antigens". J Immunol Methods. 320 (1-2): 119-131. doi:10.1016/j.jim.2007.01.001. PMID 17306825. Bollard, C. M ... "Lymphocyte enrichment using CD81-targeted immunoaffinity matrix". Cytometry A. 91A: 62-72. Pelák, O.; Kužílková, D.; Thürner, D ... "Lymphocyte enrichment using CD81-targeted immunoaffinity matrix". Cytometry A. 91A: 62-72. Neudorfer, J; Schmidt, B; Huster, K ... "Lymphocyte enrichment using CD81-targeted immunoaffinity matrix". Cytometry A. 91A: 62-72. "IBA GmbH Certified with ISO 9001: ...
CD9
... has been shown to interact with: CD117, CD29 CD46, CD49c, CD81, PTGFRN, TSPAN4. CD63 ADAM17 CD81 Tetraspanin Myogenesis ... "Molecular cloning of the CD9 antigen. A new family of cell surface proteins". The Journal of Biological Chemistry. 266 (1): 117 ... Shown in HIV-1 infection, exosomes are able to enhance HIV-1 entry through tetraspanin CD9 and CD81. However, expression of CD9 ... Tachibana I, Hemler ME (August 1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion ...
CD82 (gene)
November 1992). "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced ... Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (September 1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1 ... CD81, and CD82) at the surface of a B cell line JY". Journal of Immunology. 157 (7): 2939-46. PMID 8816400. Dong JT, Isaacs WB ... CD81 and CD82". Journal of Immunology. 155 (3): 1229-39. PMID 7636191. Horváth G, Serru V, Clay D, Billard M, Boucheix C, ...
CD37
"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of ... CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical ... Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene. The protein encoded by this gene is a member of ... Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/ ...
Integrin beta 1
CD29+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human ITGB1 genome location and ITGB1 gene ... CD29 has been shown to interact with ACTN1; CD46, CD9, FHL2, Filamin, FLNB, CD81, GNB2L1, ITGB1BP1, LGALS8, MAP4K4, NME1, PKC ... These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ...
IGSF2
Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily ... Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439-48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317. Soares ...
Microvesicles
CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... Finally, tetraspanin proteins, including CD9, CD37, CD63 and CD81 are one of the most abundant protein families found in ... This mechanism of action can be used in processes such as antigen presentation, where MHC molecules on the surface of ... For example, those released from antigen-presenting cells (APCs), such as B cells and dendritic cells, are enriched in proteins ...
CD63
... antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ... Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional ... Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC (February 1991). "CD63 antigen. A novel lysosomal ...
CD53
1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". ... 1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the ... Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. The protein encoded by this gene is a ... A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322-5. PMID 2258620. Dianzani U, ...
CD151
Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E (2001). "The major CD9 and CD81 ... Raph blood group system in the BGMUT blood group antigen gene mutation database Human CD151 genome location and CD151 gene ... identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263-70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID ... "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348-55. doi: ...
Complement receptor 1
The Knops antigen was the 25th blood group system recognized and consists of the single antigen York (Yk) a with the following ... CD81, and the fragilis/Ifitm (murine equivalents of LEU13) proteins. The complement receptor 2 (CR2) gene of primates produces ... Rao N, Ferguson DJ, Lee SF, Telen MJ (May 1991). "Identification of human erythrocyte blood group antigens on the C3b/C4b ... The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to ...
TSPAN8
"Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". ... CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical ...
Co-receptor
Carcinoembryonic antigen cell adhesion molecule-1 (Caecam1) is an immunoglobulin-like co-receptor that aids in cell adhesion in ... The Hepatitis C virus requires the CD81 co-receptor for infection. Studies suggest that the tight junction protein Claudin-1 ( ... Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death. ... or CD28 to bind antigens or regulate T cell activity in some way. Many co-receptor-related disorders occur due to mutations in ...
Chromosome 11
... squamous cell carcinoma antigen recognized by T-cells 1 SBF2: SET binding factor 2 SCGB1D2: secretoglobin family 1D member 2 ... ligand 9 CD81: cluster of differentiation 81 CDHR5: cadherin related family member 5 COMMD9: COMM domain-containing protein 9 ...
Housekeeping gene
CLTC MTX2 AP2S1 CD81 GPAA1 LGALS9 MGAT2 MGAT4B VAMP3 CTNNA1 NM_001903 CTNNB1 CTNNBIP1 NM_020248 CTNNBL1 NM_030877 CTNND1 NM_ ... in testes SPAG7 SRM Spermidine synthase TEGT Bax-1 inhibitor DAZAP2 Deleted in azoospermia MEA1 Male enhanced antigen Inducible ...
Integrin alpha 7
Kaufman SJ, Foster RF, Haye KR, Faiman LE (June 1985). "Expression of a developmentally regulated antigen on the surface of ... Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and ...
Hepatitis C virus
It prevents CD81 from latching onto its respective receptor on the virus. In addition, E2 can shield E1 from the immune system ... Walewski JL, Keller TR, Stump DD, Branch AD (2001). "Evidence for a new hepatitis C virus antigen encoded in an overlapping ... Claudin 1, which is a tight-junction protein, and CD81 link to create a complex, priming them for later HCV infection processes ... and cell-surface molecules CD81, LDL receptor, SR-BI, DC-SIGN, Claudin-1, and Occludin. The envelope of HCV is similar to very ...
KIT (gene)
KIT has been shown to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ ... Ashman LK, Cambareri AC, To LB, Levinsky RJ, Juttner CA (July 1991). "Expression of the YB5.B8 antigen (c-kit proto-oncogene ... "Signal transduction-associated and cell activation-linked antigens expressed in human mast cells". International Journal of ...
The Tetraspanin CD81 Is Necessary for Partitioning of Coligated CD19/CD21-B Cell Antigen Receptor Complexes into Signaling...
The effect of BCR cross-linking on BCR raft association in B cells from cd81+/+ and cd81−/− mice. Splenic B cells from cd81+/+ ... The effect of BCR cross-linking on BCR raft association in B cells from cd81+/+ and cd81−/− mice. Splenic B cells from cd81+/+ ... cd81+/+). The BCR and the CD19/CD21 complex were coligated on B cells from cd81+/+ and cd81−/− mice using rat Abs specific for ... vs cd81−/− B cells, the mechanism by which CD81 functions remains to be elucidated. The reduced expression of CD19 on cd81−/− B ...
Transient Hypogammaglobulinemia of Infancy: Background, Pathophysiology, Epidemiology
The B-cell antigen receptor (BCR) is associated with co-receptors CD19, CD21, CD81, and CD225, which play a critical role in B- ... CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. April 2010. 120: ... Though CD19 expression was reduced, CD21 and CD81 expressions were normal. IgM+ memory and class-switched B cells were ... They hypothesized that since CD19+ complex regulates B-cell activation following BCR-antigen stimulation, that this may lead to ...
Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells...
BST-2, CD63, CD81, CD82 and CD40L all associated with the cSMAC (Figure 2-figure supplement 5A). Tetraspanins CD81, CD63 and ... 1989) Antigen-specific helper function of cell-free T cell products bearing TCR V beta 8 determinants Science 244:1477-1480. ... 2017) CD40L is transferred to antigen-presenting B cells during delivery of T-cell help European Journal of Immunology 47:41-50 ... CD81 staining also allowed visualization of the complete SE membrane by dSTORM. BST2 may tether some SE to the T cell membrane ...
CD81 Antibodies
Order monoclonal and polyclonal CD81 antibodies for many applications. Selected quality suppliers for anti-CD81 antibodies. ... CD81 molecule (CD81) Antibodies. CD81 molecule b (cd81b) Antibodies. CD81 antigen (Cd81) Antibodies. Cd81 molecule (Cd81) ... CD81 Antibodies by Reactivity. Find CD81 Antibodies for a variety of species such as anti-Human CD81, anti-Mouse CD81, anti-Rat ... CD81 antibody (ABIN1720914) CD81 Reactivity: Human cELISA, FACS Host: Rat Monoclonal QV-6A8-S3 unconjugated ...
Transient Hypogammaglobulinemia of Infancy: Background, Pathophysiology, Epidemiology
The B-cell antigen receptor (BCR) is associated with co-receptors CD19, CD21, CD81, and CD225, which play a critical role in B- ... CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. April 2010. 120: ... Though CD19 expression was reduced, CD21 and CD81 expressions were normal. IgM+ memory and class-switched B cells were ... They hypothesized that since CD19+ complex regulates B-cell activation following BCR-antigen stimulation, that this may lead to ...
Alexa Fluor 488 anti-mouse CD19 Antibody anti-CD19 - 6D5
Antigen Details Structure Ig superfamily, associates with CD21 and CD81, 95 kD Distribution Pro-B cells to mature B cells ( ... CD21, CD81, Leu-13 Cell Type B cells, Dendritic cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD ... Antigen References 1. Fearon DT. 1993. Curr. Opin. Immunol. 5:341.. 2. Krop I, et al. 1996. Eur. J. Immunol. 26:238.. 3. Krop I ... CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation. ...
Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells | Scientific Reports
MH DELETED MN ADDED MN
Antigens, CD53 D12.776.543.982.153 D12.776.543.900.153 Antigens, CD63 D12.776.543.982.163 D12.776.543.900.163 Antigens, CD81 ... Antigens, CD9 D12.776.543.982.109 D12.776.543.900.109 Antigens, CD95 D12.776.543.750.73.500 D12.776.543.750.690.500 Antigens, ... Antigens, CD11b D12.776.543.750.705.833.62 Antigens, CD151 D12.776.543.982.251 D12.776.543.900.251 Antigens, CD19 D23.50. ... HLA-DR1 Antigen D12.776.543.550.423.400.440.400.10 D12.776.543.550.440.400.440.400.10 HLA-DR2 Antigen D12.776.543.550.423.400. ...
HCDM
A novel silicon platform for small extracellular vesicles | IJN
... while the biotinylated anti-CD81 monoclonal antibody (specific for CD81 binding) was purchased from LifeSpan BioSciences. ... Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen, Annexin A1, and ... G) Anti-CD81 signal obtained exciting its linked fluorophore Alexa 647. (H) sEVs CD81+ capture demonstration by using exosome- ... Anti-CD81 can selectively bind to the corresponding tetraspanin present on the surface of sEVs, thus anchoring the ...
CD81 antibody (CL488-65195) | Proteintech
Proteintechs Mouse Monoclonal CD81 antibody is validated in FC and shows reactivity with Human samples. ... CD81, CD81 antigen, CD81 molecule, Cell and organelle markers, Exosome marker, S5.7, TAPA1, Tetraspanin 28, Tspan 28, TSPAN28 ... CD81 is involved in signal transduction and cell adhesion in the immune system (PMID: 9597125). CD81 has also been identified ... CD81 (also known as TAPA1or TSPAN28) is a membrane protein of the tetraspanin superfamily, which are characterized by the ...
Code System Concept
xAP-0348 Mouse Monoclonal anti-Human CD81 (TAPA-1) Antibody-Angio-Proteomie
Mouse Monoclonal anti-Human CD81 (TAPA-1) Antibody, S5.7, CVID6, TSPAN28 ... Mouse Monoclonal anti-Human CD81 (TAPA-1) Antibody. Antigen Description. CD81 is a 26 kD non-glycosylated member of the ... CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates ... Home Page > ANTIBODY > MONOCLONAL ANTIBODY > Common Antibody > Mouse Monoclonal anti-Human CD81 (TAPA-1) Antibody Mouse ...
SeneQuest
IMP: Integrative Multi-species Prediction
DeCS
Antigène CD81 Entry term(s):. Antigen, CD81. Antigen, TAPA-1. Antigens, CD81. CD81 Antigen. CD81 Antigens. TAPA 1 Antigen. TAPA ... Antigen, CD81 Antigen, TAPA-1 Antigens, CD81 CD81 Antigen CD81 Antigens TAPA 1 Antigen TAPA-1 Antigen ... 2018; see ANTIGENS, CD81 2012-2017; TETRASPANIN-28 was indexed under ANTIGENS, CD 2004-2011; and under ANTIGENS, SURFACE and ... antígeno CD81 antígeno TAPA-1 antígenos CD81 Scope note:. Las proteínas tetraspaninas que participan en una variedad de ...
Spark Violet™ 423 anti-mouse CD19 Recombinant Antibody, CD19, QA17A27
CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell a ... Antigen Details Structure Ig superfamily, associates with CD21 and CD81, 95 kD Distribution Pro-B cells to mature B cells ( ... CD21, CD81, Leu-13 Cell Type B cells, Dendritic cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD ... CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation. ...
Anti Human CD81 Antibody, clone 1D6 | Bio-Rad
... recognizes human CD81, a 26 kDa cell surface antigen also known as TAPA-1, and a member of the tetraspanin family. CD81 is ... strong,Mouse anti Human CD81 antibody, clone 1D6,/strong, ... Mouse anti Human CD81 antibody, clone 1D6 is a potent CD81 ... Mouse anti Human CD81 antibody, clone 1D6 recognizes human CD81, a 26 kDa cell surface antigen also known as TAPA-1, and a ... Mouse anti Human CD81. Product Type. Monoclonal Antibody. Clone. 1D6. Isotype. IgG1. Specificity. CD81. Quick Links:. * ...
Pesquisa | Prevenção e Controle de Câncer
Well-established antigens have diagnostic limitations. This study aimed to assess the expression of CD71, CD81, CD44 and CD39 ... CD39 between CD10-negative DLBCL and MZL/LPL and CD81 between MCL and CLL. To conclude, we report the expression of CD71, CD81 ... AML are challenging because of the absence of a universal pan-AML target antigen and the shared expression of target antigens ... Expression of these 4 antigens was queried in 185 samples with a diagnosis of a B cell lymphoma according to a histological ...
CD19 - Probomed Labs Diagnostic
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as ... and the tetraspanin membrane protein CD81 (TAPA-1), as well as CD225. Through study of CD19 transgenic and knockout mouse ... models, it becomes clear that CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response ...
DeCS 2018 - Changed terms
Antigens, CD79. CD79 Antigens. Antigens, CD80. B7-1 Antigen. Antigens, CD81. Tetraspanin 28. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD79. CD79 Antigens. Antigens, CD80. B7-1 Antigen. Antigens, CD81. Tetraspanin 28. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD79. CD79 Antigens. Antigens, CD80. B7-1 Antigen. Antigens, CD81. Tetraspanin 28. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1...
... increased accessibility of the CD81 binding site without affecting the usage of CD81 and SR-BI. We finally demonstrated that ... such as studies of HCV particle composition and development of whole-virus vaccine antigens. IMPORTANCE Hepatitis C virus (HCV ... Single-cycle virus production assays in CD81-deficient Huh7-derived cells demonstrated that these changes did not affect ... increased accessibility of the CD81 binding site without affecting the usage of CD81 and SR-BI. We finally demonstrated that ...
Biotinylated Human CD19 (20-291) Protein, His,Avitag™ (SPR verified) DMF Filed
英文全称:B-lymphocyte antigen CD19 中文全称:B淋巴细胞抗原CD19 种类:Homo sapiens 上市药物数量:9详情 临床药物数量:181详情 最高研发阶段:临床三期 查看更多信息 ... It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 ... B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which ... As on T cells, several surface molecules form the antigen
MH DELETED MN ADDED MN
Antigens, CD53 D12.776.543.982.153 D12.776.543.900.153 Antigens, CD63 D12.776.543.982.163 D12.776.543.900.163 Antigens, CD81 ... Antigens, CD9 D12.776.543.982.109 D12.776.543.900.109 Antigens, CD95 D12.776.543.750.73.500 D12.776.543.750.690.500 Antigens, ... Antigens, CD11b D12.776.543.750.705.833.62 Antigens, CD151 D12.776.543.982.251 D12.776.543.900.251 Antigens, CD19 D23.50. ... HLA-DR1 Antigen D12.776.543.550.423.400.440.400.10 D12.776.543.550.440.400.440.400.10 HLA-DR2 Antigen D12.776.543.550.423.400. ...
Pediatric Common Variable Immunodeficiency Follow-up: Further Inpatient Care, Complications, Prognosis
Supplementary MaterialsSupplementary Information emboj201361s1. auxin sets off S6K1 recruitment and dissociation - Engineering...
... encoding two Mouse monoclonal to CD81.COB81 reacts with the CD81, a target for anti-proliferative antigen (TAPA-1) with 26 kDa ... CD81 play role as a member of CD19/CD21/Leu-13 signal transdiction complex. It also is reported that anti-TAPA-1 induce protein ... CD81 is broadly expressed on hemapoietic cells and enothelial and epithelial cells, but absent from erythrocytes and platelets ...
The B‐Cell Surface Receptor For Antigen (BCR) - pediagenosis
The B‐cell co‐receptor complex (Figure 4.6) is composed of four components: CD19, CD21 (complement receptor type 2, CR2), CD81 ... There is also a growing appreciation that while B‐cells can be stimulated by soluble antigen, the primary form of antigen that ... Thus, spreading along an antigen‐coated surface facilitates engagement of many BCRs with antigen, which can then be ... The B‐Cell Surface Receptor For Antigen (BCR) pediagenosis May 03, 2021 Immunology , Organ Comment ...
Tetraspanin7
- In B cells the tetraspanin CD81 is a component of the CD19/CD21 complex. (aai.org)
- CD81 (also known as TAPA1or TSPAN28) is a membrane protein of the tetraspanin superfamily, which are characterized by the presence of four conserved transmembrane regions. (ptglab.com)
- CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). (angioproteomie.com)
- CD19 functions as the dominant signaling component of a multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 (TAPA-1), as well as CD225. (probomedlabs.com)
- Mouse monoclonal to CD81.COB81 reacts with the CD81, a target for anti-proliferative antigen (TAPA-1) with 26 kDa MW, which ia a member of the TM4SF tetraspanin family. (antiviralbiologic.com)
- Here we studied the effects of blocking the integrin-associated tetraspanin CD81 in in vitro and in vivo. (tno.nl)
- Susa, K. J. , Seegar, T. Cm , Blacklow, S. C. , and Kruse, A. C. (2020) A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking . (cornell.edu)
Antibodies8
- Find CD81 Antibodies with a specific Grade. (antibodies-online.com)
- Find CD81 Antibodies for a variety of species such as anti-Human CD81, anti-Mouse CD81, anti-Rat CD81. (antibodies-online.com)
- Find CD81 Antibodies validated for a specific application such as FACS, WB, IHC, IP. (antibodies-online.com)
- Find available monoclonal or polyclonal CD81 Antibodies. (antibodies-online.com)
- Find CD81 Antibodies with a specific conjugate such as FITC, Biotin, PE. (antibodies-online.com)
- Interestingly, the E2 hypervariable region 1 (HVR1) mutation T385P caused (i) increased sensitivity to neutralizing patient IgG and human monoclonal antibodies AR3A and AR4A and (ii) increased accessibility of the CD81 binding site without affecting the usage of CD81 and SR-BI. (ox.ac.uk)
- In Chapter 2 we discussed the cunning system by which an antigen can be led inexorably to its doom by activating B‐cells that are capable of making antibodies complementary in shape to itself through interacting with a copy of the antibody molecule on the lymphocyte surface. (pediagenosis.com)
- Using human antigen-specific antibodies, FAVS was able to detect human EGFR and CD9 on exosomes isolated from the plasma of athymic nude mice bearing DiFi tumour xenografts. (exosome-rna.com)
CD1914
- In this study CD81 is shown to associate with lipid rafts upon coligation of the BCR and the CD19/CD21 complex. (aai.org)
- Using B cells from CD81-deficient mice we demonstrate that in the absence of CD81, coligated BCR and CD19/CD21 complexes fail to partition into lipid rafts and enhance BCR signaling from rafts. (aai.org)
- Furthermore, a chimeric CD19 protein that associates only weakly if at all with CD81 fails to promote the association of coligated BCR with lipid rafts. (aai.org)
- The B-cell antigen receptor (BCR) is associated with co-receptors CD19, CD21, CD81, and CD225, which play a critical role in B-cell response. (medscape.com)
- Though CD19 expression was reduced, CD21 and CD81 expressions were normal. (medscape.com)
- They hypothesized that since CD19 + complex regulates B-cell activation following BCR-antigen stimulation, that this may lead to hypogammaglobulinemia. (medscape.com)
- CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation. (biolegend.com)
- Figure B. FITC conjugated Mouse anti Human CD19 ( MCA1940F ) and RPE-Alexa Fluor 647 conjugated Mouse anti Human CD81 (MCA1847P647). (bio-rad-antibodies.com)
- Figure B. RPE conjugated Mouse anti Human CD19 ( MCA1940PE ) and Alexa Fluor 488 conjugated Mouse anti Human CD81 ( MCA1847A488 ). (bio-rad-antibodies.com)
- The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. (probomedlabs.com)
- Through study of CD19 transgenic and knockout mouse models, it becomes clear that CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction. (probomedlabs.com)
- B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. (acrobiosystems.cn)
- CD81 play role as a member of CD19/CD21/Leu-13 signal transdiction complex. (antiviralbiologic.com)
- The main proposed roles of CD19 are to recruit multimolecular complexes at the surface of mature B cells (e.g., with CD21 and CD81) and lower the signaling pathways threshold for BCRs. (nano-tag.com)
Receptors3
- The requirement for CD81 to promote lipid raft association may define a novel mechanism by which tetraspanins function as molecular facilitators of signaling receptors. (aai.org)
- b) T‐cells use distinct antigen receptors, which are also expressed at the plasma membrane, but T‐cell receptors (TCRs) cannot recognize free antigen as immunoglobulin can. (pediagenosis.com)
- It has been recently reported that there is a range of exosomal functions, it involve in intercellular transfer of membrane receptors and RNA, induction of immunity, antigen presentation, modulation of bone mineralization,[3] and antiapoptotic responses[3-7]. (envrexperts.com)
Antibody3
- In the author's studies, antibody responses to bacterial polysaccharide antigens ( S pneumoniae immunizations) were decreased. (medscape.com)
- 1X10^6 human peripheral blood lymphocytes were surface stained with 5 ul CoraLite®488-conjugated Anti-Human CD81 (CL488-65195, Clone: 5A6) (green) or isotype control antibody (black). (ptglab.com)
- It will be recalled that binding of antigen to membrane antibody can activate the B‐cell and cause it to proliferate, followed by maturation into a clone of plasma cells secreting antibody specific for the inciting antigen (Figure 4.1a). (pediagenosis.com)
CD211
- It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. (acrobiosystems.cn)
Differentiation1
- A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. (rush.edu)
Protein4
- the responses to protein immunizations are typically normal, but the responses to polysaccharide and conjugated polysaccharide antigens are typically decreased. (medscape.com)
- The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. (nih.gov)
- Originally called leukocyte common antigen (LCA), human CD45 is a type I transmembrane protein that belongs to the protein tyrosine phosphatase family ( UniProt Link ). (nano-tag.com)
- Messenger RNA (mRNA) based vaccines use lab-created mRNA that provides cells with instructions for making protein antigens and triggers an adaptive immune response. (abnova.com)
CD821
- Proteins commonly found on the surface and used as extracellular vesicle markers are tetraspanins (CD9, CD63, CD81, CD82) and major histocompatibility complex. (everzom.com)
CD452
- These include muscle side population cells that were identified based on their ability to exclude Hoechst 33342 dye from their cytoplasm as well as the presence of stem cell antigen Sca1 and CD45 proteins [ 6 ]. (biomedcentral.com)
- CD45 plays an essential role in the regulation of T- and B-cell antigen receptor signaling. (nano-tag.com)
Dendritic1
- The virus is taken up by dendritic cells, which, after antigen processing, presents it to T cells, leading to immune activation and release of a cascade of cytokines that are believed to mediate the systemic effects of plasma leakage and circulatory insufficiency. (who.int)
Receptor Complexes1
- Its extracellular functions through direct interaction with components of the antigen receptor complexes (considered as a co-stimulator) or by activating various intracellular kinases involved in the antigen receptor signaling using its phosphatase activity located in two intracellular domains. (nano-tag.com)
Specificity1
- A KIR receptor that has specificity for HLA-C ANTIGENS. (wakehealth.edu)
Intracellular1
- To our surprise, 25 hydroxyvitamin D3 [25(OH)D3], but not vitamin D3 or 1,25-dihydroxyvitaminD3, reduced the extra- and intracellular levels ofHCV core antigen in a concentration-dependent manner. (farmagens.it)
CD181
- Below are the most recent publications written about "Antigens, CD18" by people in Profiles over the past ten years. (uams.edu)
Chimeric1
- Results of an ex vivo study evaluating the phenotypic and growth characteristics of T cells collected by leukapheresis from cohorts of patients with newly diagnosed or relapsed/refractory multiple myeloma support use of chimeric antigen receptor (CAR)-T therapy earlier in course of the disease. (hematologyadvisor.com)
Endothelial cells1
- They share many antigens with vascular endothelial cells (vasculogenic mimicry) which enables them to survive in the circulation, and increases their migration and invasion capacity as well. (nature.com)
Markers1
- Blot was probed for EGFR and the exosomal markers, syntenin-1 and CD81. (exosome-rna.com)
SURFACE1
- As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. (acrobiosystems.cn)
Vitro1
- CD40L is transferred to antigen presenting cells in vitro ( Gardell and Parker, 2017 ). (elifesciences.org)
CD40L1
- Super-resolution microscopy demonstrated that CD40L is present in microclusters within CD81 defined SE that are spatially segregated from TCR/ICOS/BST-2. (elifesciences.org)
Inhibitory1
- Single-cycle virus production assay with a CD81- negative cell line reveals that the inhibitory effect of 25(OH)D3 is at the level of infectious virus assembly but not entry or replication. (farmagens.it)
Cells6
- Single-cycle virus production assays in CD81-deficient Huh7-derived cells demonstrated that these changes did not affect replication but increased HCV assembly and specific infectivity as early as 24 h posttransfection. (ox.ac.uk)
- CD81 is broadly expressed on hemapoietic cells and enothelial and epithelial cells, but absent from erythrocytes and platelets as well as neutrophils. (antiviralbiologic.com)
- Figure 4.1 B‐cells and T‐cells "see" antigen in fundamentally different ways. (pediagenosis.com)
- a) In the case of B‐cells, membrane‐bound immunoglobulin serves as the B‐cell receptor (BCR) for antigen. (pediagenosis.com)
- The majority of T‐cells can only recognize antigen when presented within the peptide‐binding groove of an MHC molecule. (pediagenosis.com)
- however, while higher in the postinduction cohort, the difference in the frequency of T cells with the CD81 CD45RO2 CD271 T-cell memory phenotype was not statistically significant when these 2 groups were compared. (hematologyadvisor.com)
Cell5
- CD81 is involved in signal transduction and cell adhesion in the immune system (PMID: 9597125). (ptglab.com)
- CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. (angioproteomie.com)
- Because secreted immunoglobulin is no longer physically connected to the B‐cell that generated it, there is no way for the B‐cell to know when the secreted Ig has found its target antigen. (pediagenosis.com)
- So how does the BCR spur the B‐cell into action upon encounter with antigen? (pediagenosis.com)
- While CAR-T therapy targeted against the B-cell maturation antigen (BCMA) has been associated with promising results in patients with multiple myeloma, nearly all of the patients responding to this approach eventually develop progressive disease. (hematologyadvisor.com)
Molecular1
- Las proteínas tetraspaninas que participan en una variedad de funciones celulares, incluido el ensamblaje de la MEMBRANA BASAL, y en la formación de un complejo molecular en la superficie de los LINFOCITOS. (bvsalud.org)
Reactivity1
- CL488-65195 targets CD81 in FC applications and shows reactivity with Human samples. (ptglab.com)
Descriptor1
- Antigens, Thy-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Development1
- This study has implications for investigations requiring high virus concentrations, such as studies of HCV particle composition and development of whole-virus vaccine antigens. (ox.ac.uk)
Major1
- This graph shows the total number of publications written about "Antigens, Thy-1" by people in this website by year, and whether "Antigens, Thy-1" was a major or minor topic of these publications. (rush.edu)