Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Antigens, CD40: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Antigens, CD28: Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Azides: Organic or inorganic compounds that contain the -N3 group.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Epitopes: Sites on an antigen that interact with specific antibodies.National Institute of Allergy and Infectious Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. It was established in 1948.Oxymetholone: A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed)Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.National Institute of General Medical Sciences (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.NIH 3T3 Cells: A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)United StatesUnited States Dept. of Health and Human Services: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to health and human services.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Pyrazoles: Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Agammaglobulinemia: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.Actinomyces viscosus: A species of ACTINOMYCES found in the oral cavity of man and hamsters. It has been isolated from actinomycotic lesions in swine, cats, and dogs and has been identified as a causative agent of animal diseases.Cirsium: A plant genus of the family ASTERACEAE. Members contain pectolinarin (a flavonoid glycoside).Seed Dispersal: The various physical methods which include wind, insects, animals, tension, and water, by which a plant scatters its seeds away from the parent plant.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Microbial Interactions: The inter- and intra-relationships between various microorganisms. This can include both positive (like SYMBIOSIS) and negative (like ANTIBIOSIS) interactions. Examples include virus - bacteria and bacteria - bacteria.IMP Dehydrogenase: An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 18.104.22.168.Biofilms: Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.Fisheries: Places for cultivation and harvesting of fish, particularly in sea waters. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Epitopes: Sites on an antigen that interact with specific antibodies.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Hybridomas: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Phycoerythrin: The metal-free red phycobilin pigment in a conjugated chromoprotein of red algae. It functions as a light-absorbing substance together with chlorophylls.Phycobilisomes: Light energy harvesting structures attached to the THYLAKOID MEMBRANES of CYANOBACTERIA and RED ALGAE. These multiprotein complexes contain pigments (PHYCOBILIPROTEINS) that transfer light energy to chlorophyll a.Phycocyanin: The metal-free blue phycobilin pigment in a conjugated chromoprotein of blue-green algae. It functions as light-absorbing substance together with chlorophylls.Bile Pigments: Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.Pigments, Biological: Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.Phycobilins: Open chain tetrapyrroles that function as light harvesting chromophores in PHYCOBILIPROTEINS.Cyanobacteria: A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.Rhodophyta: Plants of the division Rhodophyta, commonly known as red algae, in which the red pigment (PHYCOERYTHRIN) predominates. However, if this pigment is destroyed, the algae can appear purple, brown, green, or yellow. Two important substances found in the cell walls of red algae are AGAR and CARRAGEENAN. Some rhodophyta are notable SEAWEED (macroalgae).Porphyra: A genus of RED ALGAE in the family Bangiaceae. It is the most widely consumed SEAWEED in the world and especially in Asia.Light-Harvesting Protein Complexes: Complexes containing CHLOROPHYLL and other photosensitive molecules. They serve to capture energy in the form of PHOTONS and are generally found as components of the PHOTOSYSTEM I PROTEIN COMPLEX or the PHOTOSYSTEM II PROTEIN COMPLEX.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. (1/145)CD7 is an immunoglobulin superfamily molecule involved in T and natural killer (NK) cell activation and cytokine production. CD7-deficient animals develop normally but have antigen-specific defects in interferon (IFN)-gamma production and CD8(+) CTL generation. To determine the in vivo role of CD7 in systems dependent on IFN-gamma, the response of CD7-deficient mice to lipopolysaccharide (LPS)-induced shock syndromes was studied. In the high-dose LPS-induced shock model, 67% of CD7-deficient mice survived LPS injection, whereas 19% of control C57BL/6 mice survived LPS challenge (P < 0.001). CD7-deficient or C57BL/6 control mice were next injected with low-dose LPS (1 microgram plus 8 mg D-galactosamine [D-gal] per mouse) and monitored for survival. All CD7-deficient mice were alive 72 h after injection of LPS compared with 20% of C57BL/6 control mice (P < 0.001). After injection of LPS and D-gal, CD7-deficient mice had decreased serum IFN-gamma and tumor necrosis factor (TNF)-alpha levels compared with control C57BL/6 mice (P < 0.001). Steady-state mRNA levels for IFN-gamma and TNF-alpha in liver tissue were also significantly decreased in CD7-deficient mice compared with controls (P < 0.05). In contrast, CD7-deficient animals had normal liver interleukin (IL)-12, IL-18, and interleukin 1 converting enzyme (ICE) mRNA levels, and CD7-deficient splenocytes had normal IFN-gamma responses when stimulated with IL-12 and IL-18 in vitro. NK1.1(+)/ CD3(+) T cells are known to be key effector cells in the pathogenesis of toxic shock. Phenotypic analysis of liver mononuclear cells revealed that CD7-deficient mice had fewer numbers of liver NK1.1(+)/CD3(+) T cells (1.5 +/- 0.3 x 10(5)) versus C57BL/6 control mice (3.7 +/- 0.8 x 10(5); P < 0.05), whereas numbers of liver NK1.1(+)/CD3(-) NK cells were not different from controls. Thus, targeted disruption of CD7 leads to a selective deficiency of liver NK1.1(+)/ CD3(+) T cells, and is associated with resistance to LPS shock. These data suggest that CD7 is a key molecule in the inflammatory response leading to LPS-induced shock. (+info)
Reduced IL-4 and interferon-gamma (IFN-gamma) expression by CD4 T cells in patients with chronic lymphocytic leukaemia. (2/145)CD7 co-expression by CD4 T cells has been reported to be higher in the Th1 compared with the Th2 functional subset. Clinical immunodeficiency and immune dysregulation are more prevalent in the advanced stages of B cell chronic lymphocytic leukaemia (B-CLL). To analyse this further 25 patients with B-CLL and 11 healthy subjects were examined for cell surface CD7 and intracellular IFN-gamma and IL-4 expression in the peripheral blood CD4+ T helper cell population. Significantly decreased CD7, IFN-gamma and IL-4 expression was observed in the patients with B-CLL (P < 0.001). While CD7 negativity and IL-4 expression were more frequent in the later stages of the disease, this did not attain statistical significance. These results suggest a possible explanation for the reduced cellular and humoral immunity in B-CLL. (+info)
CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. (3/145)OBJECT: We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma. METHODS: These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis. MATERIALS: Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated. RESULTS: The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. All had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CD5 and CD8. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CD5, CD10 and CD13 in patient 1, CD5 in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jdelta1 induced by T-cell specific enhancer. Rearrangement of TCR beta and gamma genes occurred in patient 2, and IgH and TCR beta underwent rearrangement in patient 3. CONCLUSION: Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage. (+info)
Flow cytometric immunophenotyping in fine-needle aspiration of lymph nodes. (4/145)Fine-needle aspiration (FNA) of lymph nodes has been regarded as a useful method in the diagnosis of lymphadenopathy. However, this procedure has been shown to be of limited value in the diagnosis of low or intermediate grade malignant lymphomas in some studies. Immunophenotyping is an essential adjunct to cytomorphology for the diagnosis of lymphoma by FNA. Immunophenotyping using flow cytometry (FCM) is rapid, objective and reliable. Using FCM, multiparametric analysis of 33 FNA materials from lymph nodes was performed and profiles of surface markers of lymphoid cells were assessed. In reactive hyperplasia, patterns of cell surface markers were quite variable, but disclosed polyclonality. Most of the B-cell lymphomas showed immunophenotypes for B-cell lineages with their kappa: lambda or lambda: kappa ratio being over 3:1. In T-cell lymphomas, T-cell surface markers were predominantly expressed as well. In conclusion, our results suggest that immunophenotyping of lymph node aspirates is a valuable diagnostic adjunct for lymphoproliferative disorders, particularly in B-cell lymphomas because immunophenotyping can be easily and adequately performed by FCM. (+info)
Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. (5/145)Galectin-1 induces apoptosis of human thymocytes and activated T cells by an unknown mechanism. Apoptosis is a novel function for a mammalian lectin; moreover, given the ubiquitous distribution of the oligosaccharide ligand recognized by galectin-1, it is not clear how susceptibility to and signaling by galectin-1 is regulated. We have determined that galectin-1 binds to a restricted set of T cell surface glycoproteins, and that only CD45, CD43, and CD7 appear to directly participate in galectin-1-induced apoptosis. To determine whether these specific glycoproteins interact cooperatively or independently to deliver the galectin-1 death signal, we examined the cell surface localization of CD45, CD43, CD7, and CD3 after galectin-1 binding to human T cell lines and human thymocytes. We found that galectin-1 binding resulted in a dramatic redistribution of these glycoproteins into segregated membrane microdomains on the cell surface. CD45 and CD3 colocalized on large islands on apoptotic blebs protruding from the cell surface. These islands also included externalized phosphatidylserine. In addition, the exposure of phosphatidylserine on the surface of galectin-1-treated cells occurred very rapidly. CD7 and CD43 colocalized in small patches away from the membrane blebs, which excluded externalized phosphatidylserine. Receptor segregation was not seen on cells that did not die in response to galectin-1, including mature thymocytes, suggesting that spatial redistribution of receptors into specific microdomains is required for triggering apoptosis. (+info)
Skewed expression of activation, differentiation and homing-related antigens in circulating cells from patients with cutaneous T cell lymphoma associated with CD7- T helper lymphocytes expansion. (6/145)Mycosis fungoides and Sezary syndrome represent the most frequent forms of cutaneous T cell lymphoma. Both are characterized by skin infiltrating and/or circulating malignant cells displaying a CD4+CD7- phenotype in the majority of cases. Because an expansion of CD4+CD7- cells may also be found in inflammatory dermatoses or in the aging process, we evaluated, by flow cytometry, the relationship between CD7 expression and the distribution of differentiation/activation or homing antigens on peripheral blood lymphocytes from 36 cutaneous T cell lymphoma patients and from healthy donors. CD4+CD7- cells were increased in all patients with cutaneous T cell lymphoma. As a consequence, the CD7+/- ratio was reduced in stage I-II mycosis fungoides (3.96 vs 6.55 in healthy donors), and inverted in stage III-IV MF and Sezary syndrome (0.28 and 0.12 respectively). In the late stage of disease, the CD7+/- inverted ratio was strictly related to the expression of CD15s, CD60, and CD45R0, and the lack of expression of CD26 and CD49d. Interestingly, in leukemic patients, this phenotype was also associated with peculiar morphologic (large size) or phenotypical (CD3dim expression) characteristics. Furthermore, a progressive reduction of circulating CD8+ cells was also seen throughout all stages of disease. The presence of these populations in cutaneous T cell lymphoma at late phases of disease and Sezary syndrome suggests that all of these molecules may play an important part in the activation pathway and skin homing of circulating T cells in lymphoproliferative disorders. Therefore, this may constitute a distinctive feature in cutaneous T cell lymphoma patients with more aggressive characteristics. (+info)
CD4 + /CD7- T cell frequency and polymerase chain reaction-based clonality assay correlate with stage in cutaneous T cell lymphomas. (7/145)In cutaneous T cell lymphomas, tumor cells can be found in skin and in other compartments. A precise definition of extracutaneous spread including blood involvement is necessary for staging and treatment design. We investigated peripheral blood in 51 patients with various types of cutaneous T cell lymphomas by the analysis of blood smears for Sezary cells, the CD4 + /CD7- T helper cell frequency in the peripheral blood by fluorescence activated cell sorter analysis and by polymerase chain reaction for the T cell receptor gamma-chain followed by denaturing gradient gel electrophoresis. Eleven polymerase chain reaction products were sequenced. Thirty-five per cent of patients with stage Ia-IIb cutaneous T cell lymphomas presented a peripheral blood T cell clone. In patients with stage III-IVb cutaneous T cell lymphomas 75% were positive for clonality in the peripheral blood by polymerase chain reaction. Interestingly, three of 13 Sezary patients showed a TCR-gamma joining region pseudogene (JgammaP1/JgammaP2) usage. CD4 + /CD7- cell counts were significantly higher in patients with advanced cutaneous T cell lymphomas than in patients with early cutaneous T cell lymphomas. There was a correlation between increased percentage of circulating CD4 + /CD7- cells and detection of clonality by polymerase chain reaction (p = 0.001). There was no significant correlation between the polymerase chain reaction data and the percentage of Sezary cells on blood smears. A significant correlation between CD4 + /CD7- cells and Sezary cells was found, however. Stepwise logistic regression analysis showed that the CD4 + /CD7- cell count and clonal T cell detection in peripheral blood are independently correlated with stage. The combination of both parameters gives more information than each one separately. In conclusion, our data indicate that fluorescence activated cell sorter analysis of peripheral blood and polymerase chain reaction-based clonality assays can improve the accuracy of staging investigations in cutaneous T cell lymphomas patients. (+info)
Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (8/145)CD7 is a 40-kDa protein found primarily on T, NK, and pre-B cells; the function of the CD7 protein in the immune system is largely unknown. The K12 (SECTM1) protein was originally identified by its location just upstream of the CD7 locus. The K12 gene encodes a transmembrane protein of unknown function. In order to clone a K12-binding protein, we generated a soluble version of the human K12 protein by fusing its extracellular domain to the Fc portion of human IgG(1). Flow cytometry experiments showed that the K12-Fc fusion protein bound at high levels to both human T and NK cells. Precipitation experiments using K12-Fc on (35)S-radiolabeled NK cells lysates indicated that the K12 cognate was an approximately 40-kDa protein. A human peripheral blood T cell cDNA expression library was screened with the K12-Fc protein, and two independent, positive cDNA clones were identified and sequenced. Both cDNAs encoded the same protein, which was CD7. Thus, K12 and CD7 are cognate proteins that are located next to each other on human chromosome 17q25. Additionally, we have cloned the gene encoding the mouse homologue of K12, shown that it maps near the mouse CD7 gene on chromosome 11, and established that the mouse K12 protein binds to mouse, but not human, CD7. Mouse K12-Fc inhibited in a dose-dependent manner concanavalin A-induced proliferation, but not anti-TcRalpha/beta induced proliferation, of mouse lymph node T cells. Human K12-Fc stimulated the up-regulation of CD25, CD54, and CD69 on human NK cells in vitro. (+info)
Aruffo A, Seed B (November 1987). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system ... CD7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD7 genome location and CD7 ... CD7 CD7 molecule". Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with ... Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by ...
Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a ...
Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a ... Lee DM, Patel DD, Pendergast AM, Haynes BF (1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: ... CD7, CENTG1, CBL, EPHA2, EPOR, ERBB3, EZR, FCGR2A, GAB1, GAB2, Grb2, HRAS, IRS1 IRS2, IL1R1, JAK2, KHDRBS1, LTK, LAT, LCP2, ...
List of MeSH codes (D23)
... antigens, cd4 MeSH D23.050.301.264.035.105 --- antigens, cd5 MeSH D23.050.301.264.035.107 --- antigens, cd7 MeSH D23.050. ... antigens, cd4 MeSH D23.050.301.264.894.101 --- antigens, cd5 MeSH D23.050.301.264.894.107 --- antigens, cd7 MeSH D23.050. ... antigens, cd4 MeSH D22.214.171.124.105 --- antigens, cd5 MeSH D126.96.36.199.107 --- antigens, cd7 MeSH D188.8.131.52.108 ... antigens, cd4 MeSH D184.108.40.2064.101 --- antigens, cd5 MeSH D220.127.116.114.107 --- antigens, cd7 MeSH D18.104.22.1684.108 ...
In Lutzner cells, there is a mutation in the T-cell receptor that inhibits antigens like CD8 and CD7, but stimulates the over ... It binds to a specific antigen to initiate an immune response. T-cell antibodies bind to antigens such as virus infected cells ... Once this antigen is lost, the T-cell antibodies will never be able to detect the pathogen, allowing the pathogen to increase ... When a cutaneous lymphocyte antigen is expressed in the skin, the CD4+ Lutzner cell travels to the epidermis and dermis layers ...
... are antigens found on all T cells. They include CD2, CD3, CD5 and CD7. Mario Roederer (October 2004). Cytometry ...
T-cell prolymphocytic leukemia
... and the neoplastic cells are typically positive for pan-T antigens CD2, CD3, and CD7 and negative for TdT and CD1a. The ...
1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid- ... associated antigen CD13". Leukemia. 6 (7): 662-8. PMID 1378163. Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 ...
This process prevents the circulation of T cells that are self-reactive and recognise self antigen. Both galectin-1 and ... but specifically CD7, CD43 and CD45 are involved in apoptosis. Galectin-7 is expressed under the p53 promoter and may have a ...
The ability of T cells to recognize foreign antigens is mediated by the T cell receptor (TCR), which is a surface protein able ... Early, double negative thymocytes express (and can be identified by) CD2, CD5 and CD7. Still during the double negative stage, ... This allows single positive thymocytes to be exposed to a more complex set of self-antigens than is present in the cortex, and ... Cells which do not have a high affinity for self-antigens survive negative selection. At this stage, some cells are also ...
Immunoglobulin V-set domain
CD7; CD79A; CD79B; CD80; CD83; CD86; CD8A; CD8B; CD8B1; CD96; CEACAM1; CEACAM16; CEACAM19; CEACAM21; CEACAM3; CEACAM4; CEACAM5 ... IPR003596 T-cell surface antigen CD2 InterPro: IPR013285 ACAM; ACAN; ADAMTSL1; AGC1; AMICA1; BCAM; BCAN; BGP; BGPc; BT3.3; ...
Study to Evaluate the Safety and Tolerability of Weekly Intravenous (IV) Doses of BMS-906024 in Subjects With Acute T-cell...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Waters MassTrak™ immunossuppressants solutions integrating HPLC, mass spectrometry, software and support services, have been enhanced to include a reagent kit for the quantification of whole blood samples as an aid in the management of tacrolimus therapy.
Objectives: To evaluate the impact of myeloid antigen expression on complete remission (CR), event-free survival (EFS), and overall survival (OS) in patients with T-cell acute lymphoblastic leukemia (T-ALL) treated with intensive chemotherapy. Methods: We retrospectively reviewed consecutive patients diagnosed with T-ALL and treated in Sultan Qaboos University Hospital and Royal Hospital in Oman between 2004 and 2010. The diagnosis of T-ALL was established using French-American-British classification or World Health Organization criteria. Patients were considered having myeloid antigen expression if they expressed CD13, CD33, or both (My+ and My-). Results: Of the 39 patients, 38 were included in the study (25 patients with My- and median age of 18.4 years, 13 patients with My+ and median age of 22.0 years). Median follow-up was 12 months. Thirty-two out of the total cohort were eligible for response-rate assessment. Twenty-nine patients (90.6%) achieved CR with one or two courses of ...
Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of CTCLs and are characterized by malignant CD4+/CLA+/CCR4+ T cells that also lack the usual T cell surface markers CD7 and/or CD26. As MF/SS advances, the clonal dominance of the malignant cells results in the expression of predominantly Th2 cytokines, progressive immune dysregulation in patients, and further tumor cell growth. This review summarizes recent insights into the pathogenesis and immunobiology of MF/SS and how these have shaped current therapeutic approaches, in particular the growing emphasis on enhancement of host antitumor immune responses as the key to successful therapy.. ...
Sézary syndrome is very rare, making up ,5% of cutaneous T cell lymphomas (therefore at least 10 times less common than mycosis fungoides). It has a similar age of onset and no known aetiology. It can be considered a leukaemic version of mycosis fungoides.. ...
Question - What does EDTA to immunophenotyping ? lymphocytosis mean. - NW. Find the answer to this and other Medical questions on JustAnswer
Open-label Pilot Study of Lenalidomide (Revlimid) as Adjuvant Treatment for Refractory Cutaneous T Cell Lymphoma - Full Text...
Patients with cutaneous T cell lymphoma experience refractory and progressive disease despite current treatment, necessitating chronic disease management. In addition, there needs to be greater emphasis on combination treatment, which correlates with increased response rate, more rapid onset of response, and decreased side effect profile compared to monotherapy. The goal for the use of Lenalidomide as an adjuvant treatment in patients with refractory cutaneous T cell lymphoma is to increase response rates, maintain a durable long-term response, relieve associated symptoms, and minimize toxic side effects ...
Allogeneic stem cell transplantation may result in long-term remissions in a subset of patients with cutaneous T cell lymphomas (CTCL).
Sezary syndrome is a subtype of cutaneous T cell lymphoma which usually presents as generalized skin disease with erytheroderma. Distal organ involvement is rare and is usually a late finding in the course of the disease. Breast involvement is extremely rare. Herein, we present a case report of a patient whose initial presentation involved an intramammary lymph node prior to the onset of more characteristic skin disease. Sezary syndrome was confirmed by cythopathologic findings.
These are a superbly written set of notes with coloured annotated diagrams on the respiratory system and the circulatory system. Although written for the OCR specification they would be useful to any biology student needing to study these topics for their specification. Team these up with a set of flashcards and a quiz or two for a complete set of resources.". - ****, 2014. ...
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This volume brings together preeminent basic researchers and clinical investigators who work on cutaneous T cell lymphoma (CTCL) from different perspectives, and suggests opportunities for valuable new interdisciplinary collaborations.
Looking for online definition of cutaneous t's in the Medical Dictionary? cutaneous t's explanation free. What is cutaneous t's? Meaning of cutaneous t's medical term. What does cutaneous t's mean?
A Phase II Study of A-dmDT390-bisFv (UCHT1) Fusion Protein in Patients with Cutaneous T Cell Lymphoma (FDA IND Number: 100712).
The goal of this clinical research study is to learn the safety and efficacy of AdmDT390-bisFv (UCHT1) in patients with cutaneous T-cell lymphoma.
Bogen SA, Pelley D, Charif M, McCusker M, Koh H, Foss F, Garifallou M, Arkin C, Zucker-Franklin D. Immunophenotypic identification of Sezary cells in peripheral blood. Am J Clin Pathol. 1996 Dec; 106(6):739-48. PMID: 8980349. ...
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T cell lymphoma (CTCL).MF is a mature T cell non-Hodgkin lymphoma with presentation in the skin but with potential involvement of the nodes, blood, and viscera.
Lindahl, Lise M. and Fredholm, Simon and Joseph, Claudine and Nielsen, Boye Schnack and Jønson, Lars and Willerslev-Olsen, Andreas and Gluud, Maria and Blümel, Edda and Petersen, David L. and Sibbesen, Nina and Hu, Tengpeng and Nastasi, Claudia and Krejsgaard, Thorbjørn and Jæhger, Ditte and Persson, Jenny L. and Mongan, Nigel P. and Wasik, Mariusz A. and Litvinov, Ivan V. and Sasseville, Denis and Koralov, Sergei B. and Bonefeld, Charlotte M. and Geisler, Carsten and Woetmann, Anders and Ralfkiaer, Elisabeth and Iversen, Lars and Odum, Niels (2016) STAT5 induces miR-21 expression in cutaneous T cell lymphoma. Oncotarget . ISSN 1949-2553 ...
0012] According to the present invention, "antibody" or "immunoglobulin" have the same meaning, and will be used equally in the present invention. The term "antibody" as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that immunospecifically binds an antigen. As such, the term antibody encompasses not only whole antibody molecules, but also antibody fragments as well as variants (including derivatives) of antibodies and antibody fragments. In natural antibodies, two heavy chains are linked to each other by disulfide bonds and each heavy chain is linked to a light chain by a disulfide bond. There are two types of light chain, lambda (l) and kappa (k). There are five main heavy chain classes (or isotypes) which determine the functional activity of an antibody molecule: IgM, IgD, IgG, IgA and IgE. Each chain contains distinct sequence domains. The light chain includes two domains, a ...
Vorinostat is a targeted therapy medicine used in the treatment of Cutaneous T Cell Lymphoma (CTCL). Vorinostat is thought to work by reducing the growth and division of lymphoma cells a process in the DNA which is involved in the gene regulation in these lymphomas.. Vorinostat is an oral capsule that you take every day. Vorinostat may have the following side effects:. ...
Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas of skin-homing T- lymphocytes. The most common forms are sk...
JCVI: Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.
Citation. Finak G, Langweiler M, Jaimes M, Malek M, Taghiyar J, Korin Y, Raddassi K, Devine L, Obermoser G, Pekalski ML, Pontikos N, Diaz A, Heck S, Villanova F, Terrazzini N, Kern F, Qian Y, Stanton R, Wang K, Brandes A, Ramey J, Aghaeepour N, Mosmann T, Scheuermann RH, Reed E, Palucka K, Pascual V, Blomberg BB, Nestle F, Nussenblatt RB, Brinkman RR, Gottardo R, Maecker H, McCoy JP. Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.. Scientific Reports. 2016 Feb 10; 6: 20686.. External Citation. Abstract. Standardization of immunophenotyping requires careful attention to reagents, sample handling, instrument setup, and data analysis, and is essential for successful cross-study and cross-center comparison of data. Experts developed five standardized, eight-color panels for identification of major immune cell subsets in peripheral blood. These were produced as pre-configured, lyophilized, reagents in 96-well plates. We present the results of a ...
A 55 y/o woman was admitted to our hospital to be considered for the second renal transplant. She had agenesis of the left kidney and several stenotic segments in the right ureter which were associated with repeated pyenonephritides during her childhood. Ureteroplastic operation and partial resection of the right kidney were performed when she was 15 year old. Her renal function slowly deteriorated and at the age of 35 she started haemodialysis. A year later she received a cadaveric kidney and that graft functioned for 18 years. She underwent graftectomia and after one year on dialysis she received the second cadaveric kidney. The surgery was followed by delayed graft function, and a renal biopsy was performed on the day 6. C4d was negative and acute T-cell mediated rejection (ATCMR) grade IIA was diagnosed. She was treated with solumedrol. Her renal function slowly improved and the serum creatinine level (S-Cr) stabilized on 170μmol/l (1.9mg/dl). She felt well and came to the hospital 3 months ...
T-cell antigen CD7
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008 ...https://pharos.nih.gov/idg/targets/CD7
CD7 - Beckman Coulter
The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T ... CD7 Antigen. The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early ... CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on ... Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 ...https://www.beckman.com/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/cd7
CD7 Gene - GeneCards | CD7 Protein | CD7 Antibody
CD7 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Protein details for CD7 Gene (UniProtKB/Swiss-Prot). Protein Symbol:. P09564-CD7_HUMAN. Recommended name:. T-cell antigen CD7 ... GeneCards Summary for CD7 Gene CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Pityriasis ... No data available for DME Specific Peptides for CD7 Gene Domains & Families for CD7 Gene Gene Families for CD7 Gene. HGNC:. * ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD7
Blockade of CD7 Expression in T Cells for Effective Chimeric Antigen Receptor Targeting of T-cell Malignancies - PubMed
We selected CD7 as a target because of its consistent expression in T-cell acute lymphoblastic leukemia (T-ALL), including the ... We devised a novel approach based on chimeric antigen receptor (CAR)-redirected T lymphocytes. ... T cells with downregulated CD7 by PEBL acquire powerful cytotoxicity against CD7+leukemic cells after expression of anti-CD7 ... Blockade of CD7 Expression in T Cells for Effective Chimeric Antigen Receptor Targeting of T-cell Malignancies Yi Tian Png 1 , ...https://pubmed.ncbi.nlm.nih.gov/29296885/
HEMA 2 LEC - Mature Lymphoid Neoplasms Flashcards by Carmina Mislang | Brainscape
what cells are positive for CD138 (syndecan 1), high-density CD38 antigen, and monoclonal cytoplasmic immunoglobulins ... absence of CD7 antigen 36 How many sezary cells to be classified as sezary syndrome ...https://www.brainscape.com/flashcards/hema-2-lec-mature-lymphoid-neoplasms-4917353/packs/3744553
CD7/C13 Antibody, FITC, PE (Cocktail, MG34, E735)
CD7/C13 Cocktail Antibody, FITC, PE conjugate from Invitrogen for Flow Cytometry applications. This antibody reacts with Human ... T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41 ... CD7; CD7 antigen (p41); gp150; GP40; hAPN; LEU-9; membrane alanyl aminopeptidase; membrane protein p161; Microsomal ... Cite CD7/C13 Antibody Cocktail, FITC, PE. The following antibody was used in this experiment: CD7/C13 Antibody Cocktail, FITC, ...https://www.thermofisher.com/antibody/product/CD7-C13-Antibody-MG34-E735-Monoclonal/MA1-12284
Different gene expression profiles in normo- and dyslipidemic men after fish oil supplementation: results from a randomized...
T-cell antigen CD7 Precursor. CD7. 924. 2.30. C-C chemokine receptor-like 2 (Putative MCP-1 chemokine receptor) ...https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-11-105
Anti-CD7 antibody (Phycoerythrin) [B-F12] | Abcam
Anti-CD7 antibody conjugated to Phycoerythrin [B-F12] validated for Flow Cyt and tested in Human. Referenced in 1 publication. ... T cell surface antigen Leu 9 antibody. *T-cell antigen CD7 antibody ...https://www.abcam.com/cd7-antibody-b-f12-phycoerythrin-ab27324.html
Anti-CD7 antibody (FITC) [MEM-186] | Abcam
Anti-CD7 antibody conjugated to FITC [MEM-186] validated for Flow Cyt and tested in Human. Immunogen corresponding to synthetic ... T cell surface antigen Leu 9 antibody. *T-cell antigen CD7 antibody ... Anti-CD7 antibody [MEM-186], prediluted (PE-DyLight™ 594) (ab186072) *Anti-CD7 antibody [MEM-186], prediluted (PE/Cy7 ®) ( ...http://www.abcam.com/cd7-antibody-mem-186-fitc-ab18276.html
Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) ELISA Kit - ELISA Genie
Human T-cell antigen CD7 (CD7) ELISA Kit", "image" : "https://www.elisagenie... ... Human TALLA-1(T-cell acute lymphoblastic leukemia antigen) ELISA Kit MSRP: ... T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3E, T3E, CD3e ... ", "name" : " Human TALLA-1(T-cell acute lymphoblastic leukemia antigen) ELISA Kit", "image" : "https://www.elisagenie... ...https://www.elisagenie.com/human-t-cell-surface-glycoprotein-cd3-epsilon-chain-cd3e-elisa-kit/
Code System Concept
CD7 - Cluster of differentiation antigen 7 Current Synonym true false 1233092013 Cluster of differentiation antigen 7 Current ... Lymphocyte antigen CD7 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD7 (substance). ...https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=68851002
acute myeloblastic leukaemia without maturation 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-major] Antigens, CD56 / analysis. Antigens, CD7 / analysis. Antigens, CD79 / analysis. Antigens, Neoplasm / analysis. ... Chemical-registry-number] 0 / Antigens, CD56; 0 / Antigens, CD7; 0 / Antigens, CD79; 0 / Antigens, Neoplasm; 0 / Biomarkers, ... Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD4; 0 / Antigens, CD7; 0 / Antigens, Differentiation, Myelomonocytic ... Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, CD7; 0 / Nuclear Proteins; 117896-08-9 / nucleophosmin; EC 22.214.171.124 ...http://www.bmlsearch.com/?kwr=acute+myeloblastic+leukaemia+without+maturation+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
acute myelogenous leukemia without maturation fab m1 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-major] Antigens, CD56 / analysis. Antigens, CD7 / analysis. Antigens, CD79 / analysis. Antigens, Neoplasm / analysis. ... Chemical-registry-number] 0 / Antigens, CD56; 0 / Antigens, CD7; 0 / Antigens, CD79; 0 / Antigens, Neoplasm; 0 / Biomarkers, ... Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD4; 0 / Antigens, CD7; 0 / Antigens, Differentiation, Myelomonocytic ... Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, CD7; 0 / Nuclear Proteins; 117896-08-9 / nucleophosmin; EC 126.96.36.199 ...http://www.bmlsearch.com/?kwr=acute+myelogenous+leukemia+without+maturation+fab+m1+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
CD7 - Beckman Coulter
The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T ... CD7 Antigen. The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early ... CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on ... Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 ...https://www.mybeckman.com.br/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/cd7
Human DNMT1 Primer Pair 1 for RT-PCR (reverse transcription followed by polymerase chain reaction) analysis of mRNA expression....
Recombinant Human T-cell antigen CD7(CD7) ,partial. Express system: E.coli ... CD Antigen. FC Receptor. Immune Checkpoint. Colony Stimulating Factors. Growth Factors. Tumor Necrosis Factors. Interferons. ...https://www.cusabio.com/RT-PCR-Primers/Human-DNMT1-Primer-Pair-1-1035563.html
Recombinant Drosophila melanogaster Putative odorant receptor 42b(Or42b) - Cusabio
Recombinant Human T-cell antigen CD7(CD7) ,partial. Express system: E.coli ...https://www.cusabio.com/Transmembrane-Protein/Recombinant-Drosophila-melanogaster-Putative-odorant-receptor-42bOr42b-11150907.html
View source for CD7 - wikidoc
Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system , journal = The EMBO Journal , ... Infobox_gene}} CD7 (Cluster of Differentiation 7) is a [[protein]] that in humans is encoded by the CD7 ... Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate ... Molecular cloning of the gene coding for the human T cell differentiation antigen CD7 , journal = Immunogenetics , volume = 33 ...https://www.wikidoc.org/index.php?title=CD7&action=edit
Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal abnormality: concomitant trisomy 4 may...
Expression of CD7 antigen precludes t(8;21)(q22;q22) chromosome aberration in acute myeloblastic leukemia. Blood 1992; 79: 3092 ... and an absence of CD7 antigen expression when compared to t(8;21) negative M2 AML.9,12,30 In this study, we demonstrated that t ... frequent expression of immature B-cell antigen CD19 together with the stem cell antigen CD34. Blood 1992; 80: 470-477. ... Expression of surface antigens on t(8;21) AML. Table 4 and Figure 2 show the median percentage of positive cells, and the range ...https://www.nature.com/articles/2402871?error=cookies_not_supported&code=e7c9c5f8-6c33-446f-9b1d-a3ad36f7c1cc
Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules. ... GENE_NAME : CD7. CD_NAME : CD7. DESC: CD7 antigen (p41) OTH_NAMES: GP40; LEU-9; TP41; Tp40 ... GENE_NAME : CD7. CD_NAME : CD7. CD7 can act as a costimulatory molecule on T cells. Through binding with K12, it promotes T ... GENE_NAME : CD7. CD_NAME : CD7. T cells subsets1, thymocytes2 and NK cells.3 It is also expressed in T cell precursors4, pre-B ...http://hcdm.org/index.php/molecule-information?view=molecule&task=viewmolecule&moleculeid=234&search=
产品类别 多克隆抗体 | 博士德生物 BOSTER Biological Technology co.ltd
T-cell antigen CD7; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41; CD7; CD7 ... CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC- ... CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD81; ... T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD5; CD5; LEU1 ...http://boster.com.cn/product/index/cate/43.html?cate=43&page=6
Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features
An earlier study by us and Rausei-Mills et al., 2008 has also shown the association of coexpression of CD7 antigen with FLT3/ ... A case was considered as positive for specific antigen if the antigen was expressed in at least 20% of the leukemic cells of ... In contrast to this, FLT3/ITD mutation was associated with the higher positivity of CD7 marker (33% versus 14%; ). Further, ... while FLT3/ITD mutation was positively associated with the expression of CD7 (. ). No correlation was found between NPM1 ...https://www.hindawi.com/journals/dm/2013/582569/
6603825 - Beckman Coulter
The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T ... CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on ... Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 ... CD7 expression is also detected on pluripotent hematopoietic stem cells. ...https://www.beckman.com/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/6603825
CD7 Polyclonal Antibody, FITC Conjugated | EpiGentek
Description CD7 Polyclonal Antibody, FITC Conjugated. FITC. Raised in Rabbit. Formulation Liquid. 0.03% Proclin 300, 50% ... GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, CD7 ... Recombinant Human T-cell antigen CD7 protein (26-180AA). Storage. Shipped at 4°C. Upon delivery aliquot and store at -20°C ( ... Home » Antibodies » Primary Antibodies » Immunology & Inflammation Antibodies » Cell Marker & Receptor Antibodies » CD7 ...https://www.epigentek.com/catalog/cd7-polyclonal-antibody-fitc-conjugated-p-11046.html
CD7 - Wikipedia
Aruffo A, Seed B (November 1987). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system ... CD7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD7 genome location and CD7 ... CD7 CD7 molecule". Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with ... Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by ...https://en.wikipedia.org/wiki/CD7
Youn H Kim, MD | Stanford Medicine Profiles
These enlarged lymphocytes lacked expression of TCR beta, CD4, CD8, and the pan T-cell antigen CD7, but were positive for TCR ... The affected T cells are characterized by a predominant CD4+ phenotype with frequent loss of CD7 (pan-T-cell antigen) and often ... Immunofluorescence studies were performed using species-specific antibodies to human class I antigen, mouse class I antigen, ... Staining with the antibody to human class I antigen, W6/32, and with the antibody to mouse class I antigen, 20.8.4s, confirmed ...https://med.stanford.edu/profiles/youn-kim
- Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. (beckman.com)
- The CD7 molecule is involved in T lymphocytes activation. (beckman.com)
- CD7 (CD7 Molecule) is a Protein Coding gene. (genecards.org)
- The CD7 molecule is absent in a subset of human T cells under certain physiologic conditions. (thermofisher.com)
- Expression and function of CD7 molecule on human natural killer cells. (hcdm.org)
- Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD antigens molecule have been identified. (sinobiological.com)
- 3A1E-12H7 (ref. 6T-CD7.4) was used as a CD7 reference monoclonal antibody during HLDA 6. (beckman.com)
- The following antibody was used in this experiment: CD7/C13 Antibody Cocktail, FITC, PE from Thermo Fisher Scientific, catalog # MA1-12284, RRID AB_1073331. (thermofisher.com)
- This antibody is a monoclonal mixture of FITC-conjugated CD7 (clone MG34, isotype IgG2a) and PE-conjugated CD13 (clone E735, isotype IgG1). (thermofisher.com)
- Mouse monoclonal antibody raised against a full length recombinant CD7. (abgent.com)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
- A monoclonal antibody detecting a new human T cell antigen, HuLy-m2. (abcam.cn)
- We targeted CD7 with a second-generation CAR (anti-CD7-41BB-CD3ζ), but CAR expression in T lymphocytes caused fratricide due to the presence of CD7 in the T cells themselves. (nih.gov)
- To downregulate CD7 and control fratricide, we applied a new method (protein expression blocker [PEBL]), based on an anti-CD7 single-chain variable fragment coupled with an intracellular retention domain. (nih.gov)
- Design, expression, and signaling of the anti-CD7 CAR. (nih.gov)
- A) Schema of the anti-CD7. (nih.gov)
- Cluster of differentiation CD7 has been shown to interact with PIK3R1. (wikipedia.org)
- The CD antigens / Cluster of differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. (sinobiological.com)
- CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies. (sinobiological.com)
- Diseases associated with CD7 include Pityriasis Lichenoides Et Varioliformis Acuta and T-Cell Leukemia . (genecards.org)
- We selected CD7 as a target because of its consistent expression in T-cell acute lymphoblastic leukemia (T-ALL), including the most aggressive subtype, early T-cell precursor (ETP)-ALL. (nih.gov)
- CD7 expression is also detected on pluripotent hematopoietic stem cells. (beckman.com)
- CD7 expression remained high at relapse (n = 14), and during chemotherapy (n = 54). (nih.gov)
- CD7 expression in T-ALL. (nih.gov)
- D) Flow cytometric contour plots illustrate CD7 expression in T-ALL cells (CD3 negative) and normal T cells (CD3 positive) at diagnosis, MRD, and relapse in 1 representative patient. (nih.gov)
- PEBL-CAR T cells were highly cytotoxic against CD7 + leukemic cells in vitro and were consistently more potent than CD7 + T cells spared by fratricide. (nih.gov)
- A) The percentage of ALL cells expressing CD7 at. (nih.gov)
- Thus an increase in CD7 negative T cells can be seen in some inflammatory skin disease. (thermofisher.com)
- Non peptide antigen presentation to T-cell receptors on NKT cells. (sinobiological.com)