Antigens cd63. Medical search

Substances that are recognized by the immune system and induce an immune reaction.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Substances elaborated by bacteria that have antigenic activity.

A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation.

A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.

Substances elaborated by viruses that have antigenic activity.

Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.

Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. They have been implicated in integrin-mediated cellular adhesion and as signalling receptors on T-cells.

Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.

Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.

Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.

Antibodies produced by a single clone of cells.

The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.

Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.

A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.

Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.

A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Tetraspanin proteins found at high levels in cells of the lymphoid-myeloid lineage. CD53 antigens may be involved regulating the differentiation of T-LYMPHOCYTES and the activation of B-LYMPHOCYTES.

A cell adhesion protein that was originally identified as a heat stable antigen in mice. It is involved in METASTASIS and is highly expressed in many NEOPLASMS.

Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.

Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.

Substances of fungal origin that have antigenic activity.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The major group of transplantation antigens in the mouse.

A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.

Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.

Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.

Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Glycoproteins found on the membrane or surface of cells.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Sites on an antigen that interact with specific antibodies.

A subtype of tetraspanin proteins that play a role in cell adhesion, cell motility, and tumor metastasis. CD9 antigens take part in the process of platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.

Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.

Established cell cultures that have the potential to propagate indefinitely.

A sialic acid-rich protein and an integral cell membrane mucin. It plays an important role in activation of T-LYMPHOCYTES.

Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.

Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

Oligosaccharide antigenic determinants found principally on NK cells and T-cells. Their role in the immune response is poorly understood.

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.

A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.

A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.

Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on macrophages. CD58 mediates cell adhesion by binding to CD2; (ANTIGENS, CD2); and this enhances antigen-specific T-cell activation.

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

A ubiquitously expressed membrane glycoprotein. It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS.

A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.

The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Progenitor cells from which all blood cells derive.

The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.

GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Proteins prepared by recombinant DNA technology.

White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.

Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.

Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).

Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.

Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.

Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.

Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Tetraspanin proteins found associated with LAMININ-binding INTEGRINS. The CD151 antigens may play a role in the regulation of CELL MOTILITY.

A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.

An encapsulated lymphatic organ through which venous blood filters.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.

A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

An alpha-integrin subunit found on lymphocytes, granulocytes, macrophages and monocytes. It combines with the integrin beta2 subunit (CD18 ANTIGEN) to form LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

The processes triggered by interactions of ANTIBODIES with their ANTIGENS.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

A melanosome-specific protein that plays a role in the expression, stability, trafficking, and processing of GP100 MELANOMA ANTIGEN, which is critical to the formation of Stage II MELANOSOMES. The protein is used as an antigen marker for MELANOMA cells.

A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.

A general term for various neoplastic diseases of the lymphoid tissue.

An albumin obtained from the white of eggs. It is a member of the serpin superfamily.

Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.

An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.

A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)

A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.

A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)

Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.

A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

A cell line derived from cultured tumor cells.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.

A cell adhesion molecule of the immunoglobulin superfamily that is expressed in ENDOTHELIAL CELLS and is involved in INTERCELLULAR JUNCTIONS.

Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Antibodies obtained from a single clone of cells grown in mice or rats.

Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.

The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

The sum of the weight of all the atoms in a molecule.

Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.

Immunoglobulins produced in response to VIRAL ANTIGENS.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.

Elements of limited time intervals, contributing to particular results or situations.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

An inhibitory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN. CD274 antigen provides negative signals that control and inhibit T-cell responses and is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.

Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.

A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.

Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.

A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.

The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.

Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).

Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. (1/236)

Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defective lysosome-related organelles. Here, we report the identification of two HPS patients with mutations in the beta 3A subunit of the heterotetrameric AP-3 complex. The patients' fibroblasts exhibit drastically reduced levels of AP-3 due to enhanced degradation of mutant beta 3A. The AP-3 deficiency results in increased surface expression of the lysosomal membrane proteins CD63, lamp-1, and lamp-2, but not of nonlysosomal proteins. These differential effects are consistent with the preferential interaction of the AP-3 mu 3A subunit with tyrosine-based signals involved in lysosomal targeting. Our results suggest that AP-3 functions in protein sorting to lysosomes and provide an example of a human disease in which altered trafficking of integral membrane proteins is due to mutations in a component of the sorting machinery. (+info)

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. (2/236)

The Transmembrane 4 Superfamily member, PETA-3/CD151, is ubiquitously expressed by endothelial cells in vivo. In cultured human umbilical vein endothelial cells PETA-3 is present on the plasma membrane and predominantly localises to regions of cell-cell contact. Additionally, this protein is abundant within an intracellular compartment which accounts for up to 66% of the total PETA-3 expressed. Intracellular PETA-3 showed colocalisation with transferrin receptor and CD63 suggesting an endosomal/lysosomal localisation which was supported by immuno-electronmicroscopy studies. Co-immunoprecipitation experiments investigating possible interactions of PETA-3 with other molecules demonstrated associations with several integrin chains including beta1, beta3, beta4, (alpha)2, (alpha)3, (alpha)5, (alpha)6 and provide the first report of Transmembrane 4 Superfamily association with the (alpha)6beta4 integrin. Using 2-colour confocal microscopy, we demonstrated similar localisation of PETA-3 and integrin chains within cytoplasmic vesicles and endothelial cell junctions. In order to assess the functional implications of PETA-3/integrin associations, the effect of anti-PETA-3 antibodies on endothelial function was examined. Anti-PETA-3 mAb inhibited endothelial cell migration and modulated in vitro angiogenesis, but had no detectable effect on neutrophil transendothelial migration. The broad range of integrin associations and the presence of PETA-3 with integrins both on the plasma membrane and within intracellular vesicles, suggests a primary role for PETA-3 in regulating integrin trafficking and/or function. (+info)

Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (3/236)

We compared several responses in thrombin-stimulated and collagen (type I)-stimulated platelets with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase, Arg-Gly-Asp-Ser peptide to prevent fibrinogen/fibronectin binding to GPIIb/IIIa, SQ 29.548 as a thromboxane A2 receptor antagonist, cyproheptadine as a serotonin receptor antagonist, BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, the phosphorylation of lipids in the polyphosphoinositide cycle and phosphorylation of pleckstrin (P47) were studied as markers for signal-transducing responses, exposure of CD62 (P-selectin) and CD63 (Glycoprotein 53), as well as secretion of ADP + ATP and beta-N-acetyl-glycosaminidase were studied as final activation responses. Clear differences between thrombin-stimulated and collagen-stimulated platelets were observed. First, practically all protein-tyrosine phosphorylation induced by thrombin was inhibited by IAS, while a partial inhibition was observed for collagen; the phosphorylation due to collagen alone was apparently stimulated by elevation of cAMP. Secondly, the other responses to thrombin were inhibited by increased levels of cAMP, independent of autocrine stimulation. In contrast, only the autocrine part of the collagen-induced responses was inhibited by elevation of cAMP. Thus, the inhibition by elevated cAMP seen in collagen-stimulated platelets seems to be due to removal of the G-protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure collagen effect which is not affected by elevated levels of cAMP. (+info)

Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. (4/236)

In the field of allergy diagnosis, most in vitro functional tests are focused on basophils. Nevertheless, the very small number of circulating basophils limits these experiments and their clinical benefit remains controversial. As flow cytometry is a valuable tool for identifying cell populations, even at low concentrations, we developed a tricolour flow cytometric method for the study of allergen-induced basophil activation. Identification of cells was based both on CD45 expression and on the presence of IgE on the cell surface, since basophils express high-affinity receptors for IgE (Fc epsilon RI). Cell activation upon allergen challenge was assessed by the expression of CD63 antigen on the plasma membrane. Basophil isolation and activation (with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine) were validated in 32 non-allergic patients. In 12 allergic patients, basophil stimulation by a relevant allergen was in most cases positive (10/12). Furthermore a concentration-dependent hook effect was observed. Of the allergic and non-allergic patients, none showed non-specific activation with an irrelevant allergen (specificity 100%). Overall, our preliminary results, even in a small population, suggest that this is a reliable and valuable method for the diagnosis of allergies complementing specific allergen IgE and skin test results. Obviously, additional clinical studies are needed to validate these first results. (+info)

Rapid down-regulation of CD63 transcription by progesterone in human endometrial stromal cells. (5/236)

Differentiation of endometrial stromal cells (decidualization) plays a crucial role in embryo implantation and maintenance of pregnancy. While progesterone is a key factor in regulating endometrial cell decidualization, the molecular mechanisms remain unclear. In the present study, we investigated the effect of gene transcription in human endometrial stromal cells (ESC) by progesterone, oestrogen or vehicle using the polymerase chain reaction-based differential display methodology. A transcript which is down-regulated by progesterone, but not by vehicle and oestrogen, was identified from a differential display band and the progesterone sensitivity of its expression was verified in Northern blot analysis. The level of the gene expression in progesterone-treated ESC was approximately 60% of that in the vehicle- and oestrogen-treated ESC. This cDNA was revealed to be human CD63 antigen, a recently identified member of the transmembrane 4 superfamily. The inhibitory effect of progesterone is observed within 30 min after hormone treatment. In human endometrium, CD63 mRNA levels were significantly decreased (P < 0.05) during the secretory phase compared with levels during the proliferative phase. This down-regulation of CD63 in vivo elevated levels of progesterone in the secretory phase. These results suggest that CD63 transcription is down-regulated by progesterone in human endometrium. (+info)

Monocyte activation in patients with Wegener's granulomatosis. (6/236)

OBJECTIVE: Wegener's granulomatosis (WG) is an inflammatory disorder characterised by granulomatous inflammation, vasculitis, and necrotising vasculitis and is strongly associated with anti-neutrophil cytoplasmic antibodies (ANCA). Activated monocytes/macrophages are present in renal biopsy specimens and participate in granuloma formation by synthesising and secreting a variety of chemoattractants, growth factors, and cytokines. In view of these findings, in vivo monocyte activation was evaluated in patients with WG and the findings related to parameters of clinical disease activity. METHODS: Monocyte activation was analysed by measuring plasma concentrations of soluble products of monocyte activation, that is neopterin and interleukin 6 (IL6), by ELISA, and by quantitating the surface expression of activation markers on circulating monocytes by flow cytometry. RESULTS: Twenty-four patients with active WG were included in this study. Ten of these patients were also analysed at the time of remission. Twelve patients with sepsis served as positive controls, and 10 healthy volunteers as negative controls for monocyte activation. Patients with active disease had increased monocyte activation compared with healthy controls as shown by increased concentrations of neopterin (p < 0.0001) and increased surface expression of CD11b (p < 0.05) and CD64 (p < 0.05). In those patients with increased concentrations of IL6 during active disease plasma concentrations of IL6 decreased during follow up when patients went into remission (p < 0.0001). In addition, neopterin (r = 0.37, r = 0.44), IL6 (r = 0.37, r = 0.60) and CD63 expression (r = 0.39, r = 0.45) correlated significantly with disease activity as measured by the Birmingham Vasculitis Activity Score and C reactive protein values, respectively. Compared with patients with sepsis, all markers of monocyte activation in patients with vasculitis were lower. CONCLUSION: It is concluded that disease activity in WG correlates with the extent of activation of monocytes, compatible with their role in the pathophysiology of this disease. (+info)

Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells. (7/236)

Peptide YY (PYY) and neuropeptide Y (NPY) are peptides that coordinate intestinal activities in response to luminal and neuronal signals. In this study, using the rat hybrid small intestinal epithelial cell line, hBRIE 380i cells, we demonstrated that PYY- and NPY-induced rearrangement of actin filaments may be in part through a Y1alpha and/or a nonneuronal Y2 receptor, which were cloned from both the intestinal mucosa and the hBRIE 380i cells. A number of PYY/NPY-responsive genes were also identified by subtractive hybridization of the hBRIE 380i cells in the presence or absence of a 6-h treatment with PYY. Several of these genes coded for proteins associated with the cell cytoskeleton or extracellular matrix. One of these proteins was the transmembrane-4 superfamily protein CD63, previously shown to associate with beta(1)-integrin and implicated in cell adhesion. CD63 immunoreactivity, using antibody to the extracellular domain, was highest in the differentiated cell clusters of the hBRIE 380i cells. The hBRIE 380i cells transfected with antisense CD63 cDNA lost these differentiated clusters. These studies suggest a new role for NPY and PYY in modulating differentiation through cytoskeletal associated proteins. (+info)

CD63 associates with CD11/CD18 in large detergent-resistant complexes after translocation to the cell surface in human neutrophils. (8/236)

CD63 antibody binding to the neutrophil surface triggers a transient activation signal that regulates the adhesive activity and surface expression of CD11/CD18. Gel permeation chromatography demonstrated that all of the cell surface CD11/CD18 associated with CD63 eluted in the void volume, indicating that they were present in large detergent-resistant complexes. In contrast, the majority of the total cellular CD63, CD11 and CD18, which are largely intracellular, was not present in complexes. The data suggest that intracellular CD11, CD18 and CD63 are not in detergent-resistant complexes, but enter such complexes following translocation to the cell surface. (+info)

... antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of ... CD63+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD63 genome location and CD63 ... "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic ... Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional ...

https://en.wikipedia.org/wiki/CD63

The CD63 marker is a fluorescein isothiocyanate labeled antigen which can bind to an CD63 protein and is used to sort the cells ... the expression of the CD63 antigen on the cell surface (plasma membrane) allows identification of the allergen responsible for ... After degranulation a CD63 marker (labeled antibodies) is added to the test tube. Several minutes at room temperature gives the ... It can be used for different allergies (e.g. bee venom, drugs, contrast media). Degranulated cell expose CD63 molecules on ...

https://en.wikipedia.org/wiki/Basophil_activation

... has been shown to interact with CD19, CD63 and CD234. CD82 plays a key role in the development of endometriosis. ... November 1992). "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced ... CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039-47. ... "A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23". European ...

https://en.wikipedia.org/wiki/CD82_(gene)

CD49d+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA4 Info with links in the Cell ... CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". J. Immunol. 157 (5): 2039-47. PMID 8757325. ... "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". Hadari YR, Arbel-Goren R, Levy Y, ... Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules ...

https://en.wikipedia.org/wiki/Integrin_alpha_4

"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of ... CD53 and CD63". FEBS Letters. 288 (1-2): 1-4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540. S2CID 26316623. Berditchevski F ( ... Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene. The protein encoded by this gene is a member of ... Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/ ...

https://en.wikipedia.org/wiki/CD37

Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ... 1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta ... The tetraspanin family includes CD9, CD37, CD53, CD63, CD81 (this protein), CD82 and CD151. CD81 interacts directly with ...

https://en.wikipedia.org/wiki/CD81

It forms a alphaIIbbeta3-CD9-CD63 complex on the surface of platelets that interacts directly with other cells such as ... "Molecular cloning of the CD9 antigen. A new family of cell surface proteins". The Journal of Biological Chemistry. 266 (1): 117 ... CD63 ADAM17 CD81 Tetraspanin Myogenesis Fertilisation GRCh38: Ensembl release 89: ENSG00000010278 - Ensembl, May 2017 GRCm38: ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ...

https://en.wikipedia.org/wiki/CD9

CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... Finally, tetraspanin proteins, including CD9, CD37, CD63 and CD81 are one of the most abundant protein families found in ... This mechanism of action can be used in processes such as antigen presentation, where MHC molecules on the surface of ... For example, those released from antigen-presenting cells (APCs), such as B cells and dendritic cells, are enriched in proteins ...

https://en.wikipedia.org/wiki/Microvesicles

1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". ... 1998). "Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human ... Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene. The protein encoded by this gene is a ... A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322-5. PMID 2258620. Dianzani U, ...

https://en.wikipedia.org/wiki/CD53

Raph blood group system in the BGMUT blood group antigen gene mutation database Human CD151 genome location and CD151 gene ... CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515-25. doi:10.1177/002215549704500404. PMID 9111230. Suzuki Y ... identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263-70. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID ... "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348-55. doi: ...

https://en.wikipedia.org/wiki/CD151

"Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". ... Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals ...

https://en.wikipedia.org/wiki/TSPAN8

Subrahmanyam G, Rudd CE, Schneider H (2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a ... Israels SJ, McMillan-Ward EM (2005). "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized ... Israels SJ, McMillan-Ward EM (2005). "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized ...

https://en.wikipedia.org/wiki/PI4KA

Recently, Heneberg proposed that basophils may be defined as the cellular population positive for CD13, CD44, CD54, CD63, CD69 ... pollen proteins or helminth antigens. Recent studies in mice suggest that basophils may also regulate the behavior of T cells ... When activated, some additional surface markers are known to be upregulated (CD13, CD107a, CD164), or surface-exposed (CD63, ... of an IgE-mediated allergic response based on the upregulation of activation markers such as CD63 and/or CD203c upon suspect ...

https://en.wikipedia.org/wiki/Basophil

CD29+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human ITGB1 genome location and ITGB1 gene ... Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with ... These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 ... "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)". Hynes RO (Apr ...

https://en.wikipedia.org/wiki/Integrin_beta_1

2002). "Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to ... leukocyte histocompatibility antigen (HLA group) typing for organ transplant (mainly kidney and liver), as well as cellular ...

https://en.wikipedia.org/wiki/Alain_de_Weck

KIT has been shown to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ ... Ashman LK, Cambareri AC, To LB, Levinsky RJ, Juttner CA (July 1991). "Expression of the YB5.B8 antigen (c-kit proto-oncogene ... "Signal transduction-associated and cell activation-linked antigens expressed in human mast cells". International Journal of ...

https://en.wikipedia.org/wiki/KIT_(gene)

BST-2, CD63, CD81, CD82 and CD40L all associated with the cSMAC (Figure 2-figure supplement 5A). Tetraspanins CD81, CD63 and ... 1989) Antigen-specific helper function of cell-free T cell products bearing TCR V beta 8 determinants Science 244:1477-1480. ... 2017) CD40L is transferred to antigen-presenting B cells during delivery of T-cell help European Journal of Immunology 47:41-50 ... described soluble antigen-specific and MHC-restricted factors that delivered T cell help. Whilst Guy et al suggested a ...

https://elifesciences.org/articles/47528

Antigens, CD53 D12.776.543.982.153 D12.776.543.900.153 Antigens, CD63 D12.776.543.982.163 D12.776.543.900.163 Antigens, CD81 ... Antigens, CD9 D12.776.543.982.109 D12.776.543.900.109 Antigens, CD95 D12.776.543.750.73.500 D12.776.543.750.690.500 Antigens, ... Antigens, CD11b D12.776.543.750.705.833.62 Antigens, CD151 D12.776.543.982.251 D12.776.543.900.251 Antigens, CD19 D23.50. ... HLA-DR1 Antigen D12.776.543.550.423.400.440.400.10 D12.776.543.550.440.400.440.400.10 HLA-DR2 Antigen D12.776.543.550.423.400. ...

https://decs.bvs.br/E/mnchg2017.txt

Antigens, CD58. CD58 Antigens. Antigens, CD59. CD59 Antigens. Antigens, CD63. Tetraspanin 30. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...

https://decs2020.bvsalud.org/I/rep_i2018.htm

https://decs2019.bvsalud.org/I/rep_i2018.htm

https://decs.bvsalud.org/I/rep_i2018.htm

https://decs2018.bvsalud.org/I/rep_i2018.htm

Lymphocyte antigen CD63 Active Synonym false false 1232247016 CD63 - Cluster of differentiation antigen 63 Active Synonym false ... Lymphocyte antigen CD63 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD63 (substance). ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=6178009

CD63. CD63 antigen. U: 5. CD74. CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen- ...

https://senequest.net/search?type=go_term&search=lysosome

CD63 and vitronectin receptor αVβ3. Antibody production against these common antigens may produce an autoimmune ... 2004). The latter has been suggested as platelets share common antigens with melanoma tumor cells including glycoprotein IIb/ ... Rosenberg SA, White DE (1996) Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer ... disruption of immunologic tolerance to normal antigens) and the anti-tumor response is an active area of current research ( ...

https://springerplus.springeropen.com/articles/10.1186/s40064-015-0890-1

"Importantly, PWT143 inhibits basophil activation (as measured by surface CD63 expression in a whole blood assay) with ... suggesting a differential effect on autoimmune compared to bacterial antigen-mediated immune cell activation." ...

https://www.buhlmannlabs.ch/discovery-of-pi3k-delta-inhibitors-for-the-treatment-of-inflammatory-and-autoimmune-disease-3/

The prostate specific antigen (PSA) test for PCa remains controversial. Therefore, the development of more effective non- ... C) Western blotting of the exosomal markers CD63 and TSG101 as exosomal markers in prostatic fluid cells and exosomes. GAPDH ... Furthermore, the western blotting demonstrated that exosomes were positive for both CD63 and TSG101, two typical exosome marker ... Prostate specific antigen (PSA), secreted by prostatic epithelial cells, is widely used for the screening and diagnosis of PCa ...

https://www.spandidos-publications.com/10.3892/ol.2022.13546?text=fulltext

The tetraspanin CD63 (also known as LAMP-3) has been implicated in phagocytic and intracellular lysosome-phagosome fusion ... CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic ... A) CD63 surface expression on resting eosinophils, (B) CD63 surface expression on IFN-γ-stimulated eosinophils, (C) CD63 ... A) CD63 surface expression on resting eosinophils, (B) CD63 surface expression on IFN-γ-stimulated eosinophils, (C) CD63 ...

https://ashpublications.org/blood/article/99/11/4039/106914/Translocation-of-the-tetraspanin-CD63-in

Antigen References 1. Miao WM, et al. 2001 Blood 97:1689.. 2. Ellerman DA, et al. 2003 Mol. Biol Cell. (Epub ahead of print).. ... Associates with CD63, CD81, CD82 and CD36, binds PSG17 Cell Type B cells, Embryonic Stem Cells, Endothelial cells, Epithelial ... Antigen Details Structure Tetraspan family, type III transmembrane protein, 24 kD Distribution Platelets, B cell progenitors, ... CD9 has been shown to associate with CD63, CD81, CD82, and CD36 and to bind to β1 integrins. ...

https://www.biolegend.com/fr-fr/products/pe-anti-human-cd9-antibody-2213

The tetraspanin CD63 antigen had the best diagnostic performance for S. haematobium. The tetraspanin CD63 antigen Serum IgG POC ... The AUC for S. haematobium recombinant antigens ranged from 0.65 to 0.98, and 0.69 to 0.96 for urine IgG ELISA. S. mansoni ... recombinant antigens had sensitivities ranging from 65.3% to 100% and specificities ranging from 57.4% to 100%. Except for 4 ...

https://pesquisa.bvsalud.org/portal/?lang=es&q=mh:Schistosoma+haematobium

Giebels team further identified four different antigens [CD53, CD62L (SELL), CD63 and CD71(TFRC)] that segregate ... Since CD53, CD63 and CD71 are linked to the endosomal compartment, his group have shown both that HSC/HPCs can divide ... acquire a polarised morphology and redistribute different lipid-raft-associated antigens mainly to either the leading edge or ...

https://cob.silverchair.com/dev/article/135/9/1569/64935/Stem-cell-researchers-find-their-niche

Human Leucocyte Differentiation Antigens) Workshops and names and characterises CD molecules. ... DESC: CD9 antigen (p24) OTH_NAMES: BA2; DRAP-27; MIC3; MRP-1; P24 ... Rubinstein E, Le Naour F, Lagaudrière-Gesbert C, Billard M, Conjeaud H, Boucheix C. CD9, CD63, CD81, and CD82 are components of ... Boucheix C, Benoit P, Frachet P, Billard M, Worthington RE, Gagnon J, Uzan G. Molecular cloning of the CD9 antigen. A new ...

https://www.hcdm.org/index.php/molecule-information?view=molecule&task=viewmolecule&moleculeid=237&search=

CD63 CD63_HUMAN P08962 155740 CD63; MLA1 CD63 antigen (Melanoma-associated antigen ME491) (Lysosome-associated membrane ... Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (Meconium antigen 100) CD67 N.A. N.A. N.A ... Melanoma-associated antigen p97) CD229 LY9_HUMAN Q9HBG7 600684 LY9 T-lymphocyte surface antigen Ly-9 (Lymphocyte antigen 9) ( ... Melanoma-associated antigen MUC8) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) CD147 BASI_HUMAN ...

https://ftp.vital-it.ch/databases/swiss-prot/cdlist.txt

https://decs2017.bvsalud.org/P/mnchg2017.txt

CD63-PE antibody was added to each exosome and incubated at room temperature for 30 min. The samples without any antibody added ... After three PBS washes, the tissues were added citrate buffer for 30 min for antigen retrieval. The tissues were incubated with ... d The content of CD63 examined by flow cytometry. e The image of laser confocal microscopy. Exosomes derived from PC3 cells ... c The expression of HSP70 and CD63 measured by Western blot analysis, the content of both proteins in exosomes higher than that ...

https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01686-x

The YXX motif is found in the CI-MPR and the CD-MPR, LAMP-1, LAMP-2, and CD63, and it is involved in a wide variety of sorting ... and antigen presentation. ... LIMP-I/CD63 is a member of the tetraspannin family of proteins ... of LIMP-I/CD63 is unclear, but it seems to have a role in immune cell activation, where it is subsequently expressed at the ... LIMP-I/CD63) or di-leucine (LIMP-II)- sorting signals in the cytoplasmic domains of these molecules (25, 26). At steady-state, ...

https://schoolbag.info/chemistry/chemical_biology/83.html

WG Downregulates the Expression Levels of Chemokines, Cell Surface C6 Ceramide custom synthesis Antigens, and Th2 Cytokines in ... various cell surface antigens, for instance CD63 and CD203c, are hugely relevant to an IgE-mediated allergic reaction ... WG Downregulates the Expression Levels of Chemokines, Cell Surface C6 Ceramide custom synthesis Antigens, and Th2 Cytokines in ... 2021, 11, x FOR PEER REVIEWOur benefits showed that pretreatment with WG downregulated PMACI-induced CD63 and CD203c expression ...

http://www.icbinhibitor.com/index.php/2022/07/18/13071/

Once we understand antigens, well be able to make more universal vaccines. I think thats one of the sidelines to our recent ... Moreover, the particles expressed the glycoproteins CD63, CD71, and CD81, confirming that they were indeed exosomes. ... "These results strongly suggest that some patients can mount an immune response to antigens that are shared by different ... The chamber-based vaccine triggers an immune response by inducing the release of antigen-bearing immunogenic glioma exosomes ...

https://www.medscape.com/viewarticle/834927

Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key ... Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key ... b Macrophage markers: F4/80, Cd68, Cd63, and Cd11b; c Chemokines: Cxcl1, Cxcl10, Ccl2, and Ccr2; Inflammatory cytokines: IL1α, ... Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-like 1 (ELAVL1), functions to regulate the ...

https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-022-00910-7

Bispecific antibodies - a large family of molecules that are designed to recognize two different epitopes or antigens - come in ... BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-binding fragments, ... is used to describe a large family of molecules designed to recognize two different epitopes or antigens. ... Efficient payload delivery by a bispecific antibody-drug conjugate targeting HER2 and CD63. Mol. Cancer Ther. 15, 2688-2697 ( ...

https://www.nature.com/articles/s41573-019-0028-1?error=cookies_not_supported&code=7949f732-bad9-41eb-9c14-1fee49cf882b

Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. ... Indeed clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. ... These include antigen presentation, immune regulation, and programed cell death, each of which is linked to the cell from which ... we have successfully identified the release of CD63 and CD81 expressing exosomes from CD4+CD25hiFoxp3+ suppressive human Tregs ...

https://www.frontiersin.org/articles/10.3389/fimmu.2014.00555/full

View Donkey Anti-Mouse IgG Biotinylated Antibody (BAF018) datasheet.

https://www.rndsystems.com/products/donkey-anti-mouse-igg-biotinylated-antibody_baf018

Antigens, CD55. *Antigens, CD56. *Antigens, CD57. *Antigens, CD58. *Antigens, CD59. *Antigens, CD63 ... "Antigens, Thy-1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, Thy-1" by people in this website by year, and ... A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally ...

https://profiles.rush.edu/display/21698

Antigens, CD55. *Antigens, CD56. *Antigens, CD57. *Antigens, CD58. *Antigens, CD59. *Antigens, CD63 ... "Antigens, CD18" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, CD18" by people in UAMS Profiles by year, and ... Below are the most recent publications written about "Antigens, CD18" by people in Profiles over the past ten years. ...

https://uams-triprofiles.uams.edu/profiles/display/108439

Antigens, CD55. *Antigens, CD56. *Antigens, CD57. *Antigens, CD58. *Antigens, CD59. *Antigens, CD63 ... "Antigens, CD36" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, CD36" by people in this website by year, and whether ... Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS ...

https://profiles.uchicago.edu/profiles/display/30562

随机筛选2017年9-11月上海市公共卫生临床中心肝病科乙型肝炎病毒e抗原(hepatitis B virus e antigen, HBeAg)阳性CHB初治患者9例，无基础疾病健康者9例。采集静脉血5 mL，加入含分离胶的促凝管，室温静置至少30 ... 采用蛋白免疫印迹法检测外泌体标记蛋白的表达情况。结果显示，exoRNeasy Serum

http://jmi.fudan.edu.cn/fileup/HTML/11138.htm

CD9 has been shown to associate with CD63, CD81, CD82, and CD36 and to bind to β 1 integrins. (biolegend.com)
Proteins commonly found on the surface and used as extracellular vesicle markers are tetraspanins (CD9, CD63, CD81, CD82) and major histocompatibility complex. (everzom.com)

The chamber-based vaccine triggers an immune response by inducing the release of antigen-bearing immunogenic glioma exosomes and an antisense oligodeoxynucleotide (AS-ODN) directed against the insulin-like growth factor type 1 receptor (IGF-1R). (medscape.com)

Our study uncovers a new pathway through which induced TIMP1 critically modulates the pulmonary fibrotic response to MWCNTs by promoting fibroblast activation and proliferation via the TIMP1/CD63/integrin β1 axis and ERK signaling. (cdc.gov)

A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. (rush.edu)

The tetraspanin CD63 (also known as LAMP-3) has been implicated in phagocytic and intracellular lysosome-phagosome fusion events. (ashpublications.org)
However, ILVs also form in the absence of ESCRTs, through the action of tetraspanin CD63. (news-medical.net)

Antigens, CD36" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)

Horejsí V, Vlcek C. Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. (hcdm.org)

Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. (biomedcentral.com)
The expressions of exosomal surface protein markers CD63 and TSG101 were determined by Western blotting. (fudan.edu.cn)
The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. (nih.gov)

The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. (nature.com)
BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-binding fragments, to large immunoglobulin G (IgG)-like molecules with additional domains attached. (nature.com)

Indeed, clinical trials using DC derived exosomes to facilitate immune responses to specific cancer antigens are now underway. (frontiersin.org)
Western blotting results showed that CD63 and TSG101 were positive in exosomes. (fudan.edu.cn)

Importantly, PWT143 inhibits basophil activation (as measured by surface CD63 expression in a whole blood assay) with subnanomolar potency in response to anti-IgE stimulation but not in response to fMLP stimulation, suggesting a differential effect on autoimmune compared to bacterial antigen-mediated immune cell activation. (buhlmannlabs.ch)
We hypothesized that CD63 is associated with intracellular events involved in eosinophil activation and mediator release. (ashpublications.org)
We used a combination of confocal immunofluorescence microscopy, flow cytometry, and secretion assays, including β-hexosaminidase, eosinophil peroxidase, and RANTES, to examine CD63 expression, intracellular localization, and its association with cell activation and mediator release. (ashpublications.org)
This is the first report of an association between CD63 mobilization and agonist-induced selective mediator release, which may imply the involvement of CD63 in eosinophil activation and piecemeal degranulation. (ashpublications.org)

WG Downregulates the Expression Levels of Chemokines, Cell Surface C6 Ceramide custom synthesis Antigens, and Th2 Cytokines in PMACI-Stimulated HMC-1 Cells Chemokines are a group of chemotactic cytokines that play a vital part in directing inflammatory cell recruitment through allergic reactions [21]. (icbinhibitor.com)
2021, 11, x FOR PEER REVIEWOur benefits showed that pretreatment with WG downregulated PMACI-induced CD63 and CD203c expression in HMC-1 cells (Figure 5C).Figure four. (icbinhibitor.com)

Tissue section of human prostate containing adenocarcinoma that has been immunostained for the cell-surface antigen CD90. (ucsd.edu)

CD40L is transferred to antigen presenting cells in vitro ( Gardell and Parker, 2017 ). (elifesciences.org)
Prostate specific antigen (PSA), secreted by prostatic epithelial cells, is widely used for the screening and diagnosis of PCa. (spandidos-publications.com)
In interferon-γ (IFN-γ)- or C5a/CB-stimulated cells (10 minutes), intracellular CD63 appeared to shift to the cell periphery and plasma membrane, while stimulation with a cocktail of interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor induced the appearance of discrete intracellular clusters of CD63 immunoreactivity. (ashpublications.org)
however, these were significantly decreased by WG treatment in HMC-1 cells (Figure 5A,B). In addition to proinflammatory cytokines, various cell surface antigens, for instance CD63 and CD203c, are hugely relevant to an IgE-mediated allergic reaction correlating with histamine [23].Appl. (icbinhibitor.com)

These include antigen presentation, immune regulation, and programed cell death, each of which is linked to the cell from which they are released ( 6 , 7 ). (frontiersin.org)

This graph shows the total number of publications written about "Antigens, Thy-1" by people in this website by year, and whether "Antigens, Thy-1" was a major or minor topic of these publications. (rush.edu)

IFN-γ induced mobilization of CD63 to the cell periphery, which coincided with selective mobilization of RANTES prior to its release, implying CD63 association with piecemeal degranulation. (ashpublications.org)
Agonist-induced CD63 mobilization and cell surface up-regulation was associated with β-hexosaminidase, eosinophil peroxidase, and RANTES release. (ashpublications.org)
Dexamethasone as well as genistein (a broad-spectrum inhibitor of tyrosine kinases) inhibited agonist-induced intracellular mobilization of CD63 and RANTES together with cell surface up-regulation of CD63 and mediator release. (ashpublications.org)

Below are the most recent publications written about "Antigens, Thy-1" by people in Profiles. (rush.edu)

CD63, also known as LIMP, LAMP-3, gp55, and melanoma-associated antigen (ME491), is a member of the tetraspanin superfamily (TM4SF) that constitutes a main component of the lysosomal membrane. (biolegend.com)
Recently, LMP1 was shown to be copurified with CD63, a conserved tetraspanin protein enriched in late endosomal and lysosomal compartments. (pubfacts.com)
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. (southernbiotech.com)
The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. (neobiotechnologies.com)
Monoclonal Anti-CD63 Description Anti-CD63 recognizes an extracellular fragment of CD63, a 56 kilodalton (kd), type III lysosomal glycoprotein, belonging to the tetraspanin family. (galenlabsupplies.com)

Individuals without K antigens(K 0 ) who have formed an antibody to a K antigen, must be transfused with blood from donors who are also K 0 to prevent hemolysis. (wikidoc.org)
Autoimmune hemolytic anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red blood cells. (wikidoc.org)
SDS-PAGE Analysis Puriifed CD63 Mouse Monoclonal Antibody (LAMP3/2881). (neobiotechnologies.com)
This research modified producer advisable protocols through the use of a singular antigen retrieval methodology, including an amplification step, various major antibody incubation occasions, in addition to utilizing the Roche Ventana Ultraview detection system. (eaaci2014.com)
Utilising a monoclonal antibody panel, it allows us to evaluate the expression of both membrane and cytoplasmic antigens, permitting the characterisation and classification of different cell populations. (gen.tr)
Open up in another window Amount AMG-1694 2 Appearance of SERT, TPH1 and 5-HT in 3 unbiased tumors in the MMTV-Neu transgenic stress(A) Separate tumor areas had been incubated using a polyclonal antibody to SERT without or using a preventing peptide, the antigen utilized to elicit antibody creation in rabbits. (setac-kumamoto2012.org)
Tumor-shed antigen CA125 blocks complement-mediated killing via suppression of C1q-antibody binding. (ncbcs.org)
The membranes were probed for CD63 profiles using SBI's anti-CD63 antibody (cat# EXOAB-CD63A-1) at a 1:1,000 dilution. (reportergene.com)

CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. (lookformedical.com)
Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikidoc.org)
Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
For this reason, most of the antibodies currently available on the market fail to recognize exosome-associated antigens with sufficient sensitivity and specificity. (galenlabsupplies.com)
Western blot analysis of CD9 and CD90 of exosomes ensured the specificity of the rare available respectively cross reacting antibodies against equine antigens. (exosome-rna.com)
More specifically, "Phage Display" technology constitutes a powerful tool for the generation of specific antibodies against certain types of antigens, given the smallness of the single chain variable fragments (scFvs) and their ability to penetrate tissues. (gen.tr)
Antibodies for SMA antigen demonstrated complete negative response with neoplastic cells, but extreme positivity was noticed along the bloodstream vessel coating [Amount 3c]. (stemedics.com)
Antibodies for HMB 45 antigen demonstrated complete negative response for both neoplastic cells and stroma [Amount 3d]. (stemedics.com)
In the modern times, immune system checkpoint blockade with anti-cytotoxic T lymphocyte connected antigen 4 (CTLA-4) antibodies and anti-PD-1/PD-L1 antibodies continues to be successfully employed in the treating advanced melanoma [11-13], recommending that immunotherapy with immune checkpoint inhibitors may provide a fresh desire to advanced HCC management and treatment [14]. (health-e-nc.org)
Advancement of immunotherapy for HCC The first strategies of immunotherapy for HCC included nonspecific activation from the disease fighting capability with cytokines, and antigen-specific immunotherapy with autologous/allogeneic manufactured tumor cells, peptides, protein, DNA vaccines and tumor-specific antibodies [17]. (health-e-nc.org)

CD63 may be involved in platelet activation and is thought to function as a transmembrane adaptor protein. (biolegend.com)
Importantly, LMP1 trafficking to lipid rafts and activation of NF-κB and PI3K/Akt pathways remained intact following CD63 knockout, while mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and noncanonical NF-κB activation were observed to be increased. (pubfacts.com)
[1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. (neobiotechnologies.com)
The authors attributed this increase in CD63 and CD9 protein levels to compromised vesicle integrity after storage at room temperature. (nih.gov)
Description: Toxoplasma gondi antigen, purified native protein. (dharchive.org)
This gene encodes the Ig-beta protein of the B-cell antigen component. (elisa-kits.de)
Furthermore, glycoproteins with the Tn antigen have different subcellular distributions in different cells, which may be attributed to the distinct mechanisms for the formation of protein O-GalNAcylation. (mcw.edu)

CD63 is identical to the melanoma-associated antigen ME491 and to the platelet antigen PTLGP40. (abcam.cn)

12. T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells. (nih.gov)
14. Fully human CD19-specific chimeric antigen receptors for T-cell therapy. (nih.gov)
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. (lookformedical.com)
CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (lookformedical.com)

Another vaccine strategy may be the usage of a serotype-independent vaccine using conserved common pneumococcal proteins antigens. (ink-128.com)
The benefit of a proteins vaccine can be that protection wouldn't normally become serotype reliant and fewer antigen applicants could offer a higher coverage with a lesser price of manufacturing. (ink-128.com)
One typical example is proteins modified with O-linked β- N -acetylglucosamine ( O -GlcNAc) and O-linked α- N -acetylgalactosamine (O-GalNAc) (the Tn antigen), in which the two glycans have very similar structures and identical chemical compositions, making them extraordinarily challenging to be distinguished. (mcw.edu)

To reduce the systemic toxicity of doxorubicin, PSA (prostate specific antigen) - activated doxorubicin prodrug will be used in this project, where drug activation takes place only in PSA-producing PC cells. (ukdiss.com)
RNA was isolated from EVs using a HansaBiomed RNA Isolation Kit and levels of B-actin, prostate specific antigen (PSA), and ENY4 were quantified by real-time PCR. (nih.gov)
Owing to loss of AR signaling, these patients present with low serum prostate-specific antigen (PSA). (nature.com)

Immunoisolation of CD63-positive exosomes exhibited accumulation of LMP1 in this vesicle population. (pubfacts.com)
Extracellular vesicles (EVs), including exosomes, express antigens with 3D conformations and/or post-translational modifications that often differ from the cellular counterpart. (galenlabsupplies.com)
discovered that B lymphocyte-derived exosomes have multiple functions, including antigen presentation, T lymphocyte activation, and immune cell function regulation. (frontiersin.org)
Starting with cells grown in Exo-FBS (our exosome-depleted FBS) to maximize purity, exosomes are isolated using ExoQuick-TC® and then quality checked by Western blot for the presence of CD63, and NanoSight for particle size and intactness. (reportergene.com)

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. (lookformedical.com)
The KEL gene encodes a type II transmembrane glycoprotein [5] that is the highly polymorphic Kell blood group antigen. (wikidoc.org)

We have previously shown a promising approach to treat autoimmune disease by inducing antigen-specific regulatory T cells through apoptotic cell-driven release of TGF by macrophages together with specific autoantigen peptide administration10. (africagis2009.org)

The aim of this project is to prepare PSMA (prostate-specific membrane antigen) targeted, exosome-like vesicles, encapsulating doxorubicin prodrug that will selectively target metastatic PC cells. (ukdiss.com)

These findings demonstrate the capacity of universal DEX vaccines to induce tumor-specific immune responses by triggering an immune response tailored to the tumors of each individual, thus presenting a generalizable approach for personalized immunotherapy of HCC, by extension of other tumors, without the need to identify tumor antigens. (biomedcentral.com)
We believe that a strategy enabling targeted recruitment and activation of endogenous DCs to tumor sites can stimulate cross-presentation of tumor antigens and allow generation of tumor-specific immune responses against neoantigens within the tumor, thus achieving the goal of personalized immunotherapy without the need and regulatory nightmare of developing individualized products for each patient. (biomedcentral.com)
Recruited DCs cross-presented tumor antigens and triggered antigen-specific de novo immune responses, and significant tumor retardation in orthotopic HCC mice bearing large established tumors. (biomedcentral.com)
However, tumor microenvironment of HCC can be immunogenic and complicated, it generally does not just communicate tumor antigens, but also orchestrate numerous hepatic antigens presenting cells and promote evasion of tumor cells therefore. (health-e-nc.org)

CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. (neobiotechnologies.com)

17. Identification of CD19 and CD20 peptides for induction of antigen-specific CTLs against B-cell malignancies. (nih.gov)
Antigens, CD20" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Antigens, CD20" by people in Harvard Catalyst Profiles by year, and whether "Antigens, CD20" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Antigens, CD20" by people in Profiles. (harvard.edu)

IMSC profoundly communicates antigen markers, including CD73, CD29, CD44, and CD146, yet doesn't communicate CD34, CD45, CD133, and HLA-DR . SEVs were segregated and gathered from the sans serum culture mechanism of iMSC by standard differential centrifugation convention. (active-earth.net)

PD-L1 co-localized with Hrs and CD63, an exosome marker, in melanoma cells (Extended Data Fig. 1j, k). (sanofibiotalentchallenge.ca)
All exosome preps are checked for the presence of CD63, a common exosome marker, via Western blotting (Figure 1). (reportergene.com)

CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling. (pubfacts.com)
These results suggest that CD63 is a critical player in LMP1 exosomal trafficking and LMP1-mediated enhancement of exosome production and may play further roles in limiting downstream LMP1 signaling. (pubfacts.com)
9. Pancreatic Pre-malignant Lesions Secrete TIMP1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Pre-Metastatic Niche in the Liver. (imi-muenchen.de)

Furthermore, LMP1 packaging was severely impaired in CD63 knockout cells, concomitant with a disruption in the perinuclear localization of LMP1. (pubfacts.com)

CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. (neobiotechnologies.com)

Thioglycolate-elicited BALB/c mouse peritoneal macrophages were fixed, permeabilized and intracellularly stained with purified CD63 (clone NVG-2) (left) or purified rat IgG2a, κ isotype control (right), followed by biotinylated anti Rat IgG, SAV PE, and CD11b APC. (biolegend.com)

5. Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver. (imi-muenchen.de)

Targeting Two Antigens Associated with B-ALL with CD19-CD123 Compound Car T Cell Therapy. (harvard.edu)

bEnd.3, mouse endothelial cells were stained with purified CD63 (clone NVG-2) (filled histogram) or rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE. (biolegend.com)

The Kell antigen system (also known as Kell-Cellano system ) is a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikidoc.org)
The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
Stream cytometry was applied to assess the surface antigen profile of these cells to recognize iMSC. (active-earth.net)
The age of mesenchymal undifferentiated organisms from human instigated pluripotent foundational microorganisms as beforehand described.30 Surface antigens of iMSCs were examined by stream cytometry. (active-earth.net)

A recent report shows that CD63-deficient mice exhibit a significant reduction in both leukocyte rolling and recruitment in a peritonitis model. (biolegend.com)
CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. (neobiotechnologies.com)
In addition, the paucity of known neoepitopes presented in human leukocyte antigen class I complexes for nonsynonymous HCC mutations in patients raised the concern that neoantigen-specific T cells alone might not be adequate to exert cytotoxic killing in HCC [ 6 ]. (biomedcentral.com)

Differentiation antigens residing on mammalian leukocytes. (lookformedical.com)
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. (lookformedical.com)
Differentiation antigens expressed on B-lymphocytes and B-cell precursors. (lookformedical.com)
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. (lookformedical.com)

4. Chapatte L, Colombetti S, Cerottini J, Lévy F. Efficient induction of tumor antigen-specific CD8 + memory T cells by recombinant lentivectors. (southernbiotech.com)

As shown in Fig.?1a, the characteristic markers of EVs, including CD63, TSG101, Alix and HSP 90, were enriched in EVs fraction, compared with total cell lysates. (africagis2009.org)

[1] It was found to have a high affinity binding site and is expressed by antigen-activated T lymphocytes ( T cells ). (bionity.com)

CD63 deficient mice are viable, and there is no alteration in the population of immune cells. (biolegend.com)
Langerhans cells process the antigens and present them to cutaneous T cells. (medscape.com)
Antigens on surfaces of cells, including infectious or foreign cells or viruses. (lookformedical.com)
Tissue, cells or virus corresponding to CD63. (abcam.cn)
The neoplastic cells demonstrated diffuse, extreme cytoplasmic positivity for cytokeratin AE1/AE3 [Amount 3a] as well as for vimentin antigen extreme positive response was seen just inside the tumor stroma as well as the neoplastic cells demonstrated negative response [Amount 3b]. (stemedics.com)
Xu S, Zheng J, Xiao H, Wu R. Simultaneously Identifying and Distinguishing Glycoproteins with O -GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells. (mcw.edu)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care3

Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. (1/236)

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. (2/236)

Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (3/236)

Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. (4/236)

Rapid down-regulation of CD63 transcription by progesterone in human endometrial stromal cells. (5/236)

Monocyte activation in patients with Wegener's granulomatosis. (6/236)

Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells. (7/236)

CD63 associates with CD11/CD18 in large detergent-resistant complexes after translocation to the cell surface in human neutrophils. (8/236)

Antigens

Antigens, CD

Antigens, CD8

Antigens, Neoplasm

Antigens, CD3

Antigens, Surface

Antigens, Bacterial

Antigens, CD38

Antigens, CD34

Antigens, CD19

Antigens, CD40

CD40 Ligand

Antigens, CD20

Antigens, Viral

Antigens, CD28

Antigens, CD44

Antigens, CD7

Antigens, CD14

Antigens, CD2

CD4-CD8 Ratio

Antigens, CD5

Antigens, Differentiation

CD4-Positive T-Lymphocytes

Antigens, CD1

Antibodies, Monoclonal

Antigens, CD56

Antigens, Differentiation, T-Lymphocyte

ADP-ribosyl Cyclase

Antigens, Differentiation, Myelomonocytic

Antigens, CD80

Antigens, CD53

Antigens, CD24

Antigens, CD13

Antigens, Protozoan

T-Lymphocytes

Antigens, CD86

Flow Cytometry

B-Lymphocytes

Antigens, Polyomavirus Transforming

Antigens, CD95

HLA Antigens

Antigens, Differentiation, B-Lymphocyte

Antigens, CD45

Immunophenotyping

NAD+ Nucleosidase

Antigens, Fungal

Molecular Sequence Data

H-2 Antigens

Sialic Acid Binding Ig-like Lectin 3

Antigens, Helminth

Receptors, Antigen, T-Cell

Antigens, CD18

Lymphocyte Activation

Antigens, CD30

Membrane Glycoproteins

CD8-Positive T-Lymphocytes

Epitopes

Antigens, CD9

Carcinoembryonic Antigen

HLA-DR Antigens

Antigens, CD15

Antigens, Viral, Tumor

Cell Line

Antigens, CD43

Antigens, CD36

Amino Acid Sequence

Antigens, CD11

Histocompatibility Antigens Class II

Histocompatibility Antigens

Antigens, CD59

Receptors, Antigen, B-Cell

Proliferating Cell Nuclear Antigen

Antigens, CD57

Antigens, CD70

Antigens, CD46

Lectins, C-Type

Antigens, CD58

Antigens, CD4

Antigens, CD47

Antigens, CD11b