BooksABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Book SelectionBook Reviews as Topic: Critical analyses of books or other monographic works.French Revolution: Conflict during which traditional monarchy was ended and modern government functions were instituted.Rare BooksBook PricesBooks, Illustrated: Books containing photographs, prints, drawings, portraits, plates, diagrams, facsimiles, maps, tables, or other representations or systematic arrangement of data designed to elucidate or decorate its contents. (From The ALA Glossary of Library and Information Science, 1983, p114)Reference Books, Medical: Books in the field of medicine intended primarily for consultation.History, 18th Century: Time period from 1701 through 1800 of the common era.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Neurothekeoma: A benign myxoma of cutaneous nerve sheath origin. Theke is from the Greek theke, sheath. (From Stedman, 25th ed)Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Thyroid Nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).Thyroid Diseases: Pathological processes involving the THYROID GLAND.Thyroiditis, Autoimmune: Inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Adenoma: A benign epithelial tumor with a glandular organization.Myelin-Associated Glycoprotein: A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.Killer Cells, Natural: Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.Myelin Proteins: MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.Ectoderm: The outer of the three germ layers of an embryo.T-Lymphocytes, Regulatory: CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Cytotoxicity, Immunologic: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Antigens, CD40: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Antigens, CD28: Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.CD4-CD8 Ratio: Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Antigens, CD14: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.Neuroectodermal Tumor, Melanotic: A benign, rapidly growing, deeply pigmented tumor of the jaw and occasionally of other sites, consisting of an infiltrating mass of cells arranged in an alveolar pattern, and occurring almost exclusively in infants. Its source of origin is in dispute, the various theories giving rise to its several names. (Dorland, 27th ed)Ploidies: The degree of replication of the chromosome set in the karyotype.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Karyotyping: Mapping of the KARYOTYPE of a cell.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Spectral Karyotyping: The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.Chromosome Banding: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.Chromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.V-Set Domain-Containing T-Cell Activation Inhibitor 1: A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Epitopes: Sites on an antigen that interact with specific antibodies.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Hybridomas: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Mice, Inbred BALB CMelanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Self-Examination: The inspection of one's own body, usually for signs of disease (e.g., BREAST SELF-EXAMINATION, testicular self-examination).Skin Neoplasms: Tumors or cancer of the SKIN.Dermoscopy: A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.Melanoma, Experimental: Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.Nevus: A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Uveal Neoplasms: Tumors or cancer of the UVEA.Melanoma, Amelanotic: An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)Th2 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.Th1 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.Chromatin: The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.Th17 Cells: Subset of helper-effector T-lymphocytes which synthesize and secrete IL-17, IL-17F, and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Interleukin-4: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.Interleukin-17: A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Interleukins: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Formation of HNK-1 determinants and the glycosaminoglycan tetrasaccharide linkage region by UDP-GlcUA:Galactose beta1, 3-glucuronosyltransferases. (1/260)While expression-cloning enzymes involved in heparan sulfate biosynthesis, we isolated a cDNA that encodes a protein 65% identical to the UDP-GlcUA:glycoprotein beta1, 3-glucuronosyltransferase (GlcUAT-P) involved in forming HNK-1 carbohydrate epitopes (3OSO3GlcUAbeta1,3Gal-) on glycoproteins. The cDNA contains an open reading frame coding for a protein of 335 amino acids with a predicted type II transmembrane protein orientation. Cotransfection of the cDNA with HNK-1 3-O-sulfotransferase produced HNK-1 carbohydrate epitopes in Chinese hamster ovary (CHO) cells and COS-7 cells. In vitro, a soluble recombinant form of the enzyme transferred GlcUA in beta-linkage to Galbeta1,3/4GlcNAcbeta-O-naphthalenemethanol, which resembles the core oligosaccharide on which the HNK-1 epitope is assembled. However, the enzyme greatly preferred Galbeta1, 3Galbeta-O-naphthalenemethanol, a disaccharide component found in the linkage region tetrasaccharide in chondroitin sulfate and heparan sulfate. During the course of this study, a human cDNA clone was described that was thought to encode UDP-GlcUA:Galbeta1,3Gal-R glucuronosyltransferase (GlcUAT-I), involved in the formation of the linkage region of glycosaminoglycans (Kitagawa, H., Tone, Y., Tamura, J., Neumann, K. W., Ogawa, T., Oka, S., Kawasaki, T., and Sugahara, K. (1998) J. Biol. Chem. 273, 6615-6618). The deduced amino acid sequences of the CHO and human cDNAs are 95% identical, suggesting that they are in fact homologues of the same gene. Transfection of a CHO cell mutant defective in GlcUAT-I with the hamster cDNA restored glycosaminoglycan assembly in vivo, confirming its identity. Interestingly, transfection of the mutant with GlcUAT-P also restored glycosaminoglycan synthesis. Thus, both GlcUAT-P and GlcUAT-I have overlapping substrate specificities. However, the expression of the two genes was entirely different, with GlcUAT-I expressed in all tissues tested and GlcUAT-P expressed only in brain. These findings suggest that, in neural tissues, GlcUAT-P may participate in both HNK-1 and glycosaminoglycan production. (+info)
Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (2/260)BACKGROUND: The granulomatous inflammation in sarcoidosis is driven by the interplay between T cells and macrophages. To gain a better understanding of this process the expression by these cells of cell surface activation markers, co-stimulatory molecules, and adhesion molecules was analysed. METHODS: CD4+ and CD8+ T lymphocytes from peripheral blood (PBL) or bronchoalveolar lavage (BAL) fluid, as well as paired peripheral blood monocytes and alveolar macrophages from 27 patients with sarcoidosis were analysed by flow cytometry. RESULTS: CD26, CD54, CD69, CD95, and gp240 were all overexpressed in T cells from BAL fluid compared with those from PBL in both the CD4+ and CD8+ subsets, while CD57 was overexpressed only in BAL CD4+ cells. In contrast, CD28 tended to be underexpressed in the BAL T cells. Monocyte/macrophage markers included CD11a, CD11b, CD11c, CD14, CD16, CD54, CD71, CD80 and CD86 and HLA class II. CD11a expression in alveolar macrophages (and peripheral blood monocytes) was increased in patients with active disease and correlated positively with the percentage of BAL lymphocytes. Expression of CD80 in macrophages correlated with the BAL CD4/CD8 ratio. CONCLUSIONS: Our data indicate substantial activation of both CD4+ and CD8+ lung T cells in sarcoidosis. There were also increased numbers of BAL lymphocytes whose phenotypic characteristics have earlier been associated with clonally expanded, replicatively senescent cells of the Th1 type. (+info)
Thrombospondin-1 and neural crest cell migration. (3/260)Using a monoclonal antibody raised against human platelet thrombospondin, we found anti-thrombospondin immunoreactivity in the extracellular matrix of avian embryos, coincident with the ventral pathways followed by trunk neural crest cells. To confirm that the antibody recognized thrombospondin-1 and to determine the tissue of origin of the thrombospondin matrix, a thrombospondin-1 cRNA probe was used for whole mount in situ hybridization. This probe revealed thrombospondin-1 mRNAs in the developing myotome before and during neural crest cell migration. The effect of thrombospondin-1 on neural crest cell migration, morphology, and adhesion was assayed in vitro. Quail trunk neural crest cells cultured on 4 microg/ml of thrombospondin-1 migrate at 1.14 +/- 0.54 microm/min, which is significantly greater than the rate of cell migration on tissue culture plastic. Using a shaker-based adhesion assay, a significantly greater number of neural crest cells remain attached to dishes coated with 4 microg/ml of thrombospondin-1 than to tissue culture plastic alone. The number of neural crest cells that remain attached to 4 microg/ml of thrombospondin-1 is similar to the number that remain attached to dishes coated with 10 microg/ml of fibronectin. These observations indicate that neural crest cells migrate through a thrombospondin-filled extracellular matrix, and that thrombospondin-1 promotes neural crest cell migration and adhesion. Thus, thrombospondin-1 is the first somite-derived extracellular matrix molecule with properties consistent with a role in the promotion of migration into the anterior somite, as opposed to the repulsion of neural crest cells from the posterior half of the somite. (+info)
Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood. (4/260)We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28- T cells. Sequencing of the TCRBV14 amplification products showed a TCR sequence which contributed 32% of the total TCR in the CD8+TCRBV14 population. Using the modified heteroduplex technique, the CD8+TCRBV14 cells showed a clonal pattern and these bands were restricted to the CD28- population. This method also detected multiple other clones within the CD8+ population but few in the CD4+ cells. The dominant TCRBV14+ clone was not detectable in synovial fluid T cells from two inflamed joints by CDR3 length analysis or heteroduplex probing, suggesting that this long-lived clone is excluded from inflammatory sites. Synovial fluid T cells showed an unexpected discordance of the CD28 and CD57 phenotype compared to peripheral blood mononuclear cells. T cells from both inflamed joints both showed marked oligoclonality in all TCR families and had almost identical heteroduplex patterns. Taken together these data suggest that some clones are actively excluded from inflamed sites in juvenile chronic arthritis, yet the pattern of restricted T cell expansion is shared between sites of inflammation. (+info)
Cloning and expression of a novel galactoside beta1, 3-glucuronyltransferase involved in the biosynthesis of HNK-1 epitope. (5/260)We isolated a cDNA encoding a novel glucuronyltransferase, designated GlcAT-D, involved in the biosynthesis of the HNK-1 carbohydrate epitope from rat embryo cDNA by the degenerate polymerase chain reaction method. The new cDNA sequence revealed an open reading frame coding for a protein of 324 amino acids with type II transmembrane protein topology. The amino acid sequence of GlcAT-D displayed 50.0% identity to rat GlcAT-P, which is involved in the biosynthesis of the HNK-1 epitope on glycoproteins. Expression of GlcAT-D in COS-7 cells resulted in the formation of the HNK-1 epitope on the cell surface. The enzyme expressed in COS-7 cells transferred a glucuronic acid (GlcA) not only to asialo-orosomucoid, a glycoprotein bearing terminal N-acetyllactosamine structure, but also to paragloboside (lacto-N-neotetraosylceramide), a precursor of the HNK-1 epitope on glycolipids. Furthermore, substrate specificity analysis using a soluble chimeric form of GlcAT-D revealed that GlcAT-D transfers a GlcA not only to Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-pyridylamine++ + but also to Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc-pyridylamine++ +. Enzymatic hydrolysis and Smith degradation of the reaction product indicated that GlcAT-D transfers a GlcA through a beta1,3-linkage to a terminal galactose. The GlcAT-D transcripts were detected in embryonic, postnatal, and adult rat brain. In situ hybridization analysis revealed that the expression pattern of GlcAT-D transcript in embryo is similar to that of GlcAT-P, but distinct expression of GlcAT-D was observed in the embryonic pallidum and retina. Regions that expressed GlcAT-D and/or GlcAT-P were always HNK-1-positive, indicating that both GlcATs are involved in the synthesis of the HNK-1 epitope in vivo. (+info)
Peripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression. (6/260)At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-) (CD57(+) or CD57(-)) subpopulations remain unresolved. Here, we compared the differentiation of CD8(+)CD28(bright)CD57(-) T cells purified from healthy adults or neonates and propagated in IL-2, alone or with IL-4. With IL-2 alone, CD8(+)CD28(bright)CD57(-) T cell cultures yielded a prevailing CD28(-) subpopulation. The few persisting CD28(dim) and the major CD28(-) cells were characterized by similar telomere shortening at the plateau phase of cell growth. Cultures from adults donors generated four final CD8(+) phenotypes: a major CD28(-)CD57(+), and three minor CD28(-)CD57(-), CD28(dim)CD57(-) and CD28(dim)CD57(dim). These four end-stage CD8(+) subpopulations displayed a fairly similar representation of TCR V(beta) genes. In cultures initiated with umbilical cord blood, virtually all the original CD8(+)CD28(bright) T cells lost expression of CD28, but none acquired CD57 with IL-2 alone. IL-4 impacted on the differentiation pathways of the CD8(+)CD28(bright)CD57(-) T cells: the addition of IL-4 led both the neonatal and the adult lymphocytes to keep their expression of CD28. Thus, CD8(+)CD28(bright)CD57(-) T cells can give rise to four end-stage subpopulations, the balance of which is controlled by both the cytokine environment, IL-4 in particular, and the proportions of naive and memory CD8(+)CD28(+) T cells. (+info)
Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population. (7/260)The proportion of human peripheral blood CD8+ T cells that are CD57+ CD28- is low at birth but increases with age and in individuals infected with human cytomegalovirus (HCMV) or human immunodeficiency virus (HIV). These CD57+ CD28- CD8+ T cells contain large oligoclonal T-cell expansions whose antigen specificity is unknown. We identified clonal expansions of virus-specific memory cytotoxic T-lymphocyte precursors (CTLp) in both healthy carriers of HCMV and in asymptomatic HIV-infected subjects. In each subject, from the T-cell receptor (TCR) beta-chain hypervariable sequence of each immunodominant CTL clone, we designed complementary oligonucleotide probes to quantify the size and phenotypic segregation of individual virus-specific CTL clones in highly purified populations of peripheral blood CD8+ T cells. We found large clonal expansions of virus-specific CTL clonotypes in CD57+ CD28- CD8+ T cells. Using limiting dilution analysis, we found functional peptide-specific CTLp at high frequency in CD57+ CD28- cells. Thus, memory CTL specific for persistent viruses account for many oligoclonal expansions within CD57+ CD28- CD8+ T cells. (+info)
CD8+, CD57+ T cells from healthy elderly subjects suppress neutrophil development in vitro: implications for the neutropenia of Felty's and large granular lymphocyte syndromes. (8/260)OBJECTIVE: To investigate the ability of CD8+,CD57+ large granular lymphocytes (LGL) from normal individuals and from Felty's syndrome (FS) or LGL syndrome patients to suppress allogeneic neutrophil precursor development. METHODS: Six FS patients, 5 LGL syndrome patients, and 13 elderly controls were studied. CD8+,CD57+ T cells were cocultured with cord blood-derived stem cells, and percentage inhibition was calculated. Recombinant chemokines and Fas-stimulating molecules were used in separate cultures to address possible mechanisms of suppression. Proliferation after stimulation with interleukin-2 (IL-2) and anti-CD3 was assessed. RESULTS: Significant (79%) suppression of colony-forming unit-granulocyte-macrophage (CFU-GM) by the CD8+,CD57+ subset was shown by 1 FS patient. None of the CD8+,CD57+ cells from LGL syndrome patients had any effect. Six of 13 controls studied showed >40% inhibition of CFU-GM, and all but 2 showed at least some suppression. The suppressive effect was not mediated by Fas/Fas ligand interactions or by the chemokines macrophage inhibitory protein 1alpha or IL-8. LGL from both patients and controls were largely CD28- and had reduced proliferative capacity. CONCLUSION: In a subset of FS patients, expansion of CD8+,CD57+ T cells in the bone marrow may be responsible for neutropenia by suppressing neutrophil precursors. This effect is also seen with normal LGL, which are likely to have an important function in neutrophil homeostasis. (+info)
... whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands ... CD57 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human B3GAT1 genome location and B3GAT1 ... "Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells". Blood. 101 (7): 2711-20 ... also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. In anatomical pathology, CD57 ...
List of MeSH codes (D23)
... antigens, cd55 MeSH D23.050.301.264.035.156 --- antigens, cd56 MeSH D23.050.301.264.035.157 --- antigens, cd57 MeSH D23.050. ... antigens, cd28 MeSH D23.050.301.264.894.156 --- antigens, cd56 MeSH D23.050.301.264.894.157 --- antigens, cd57 MeSH D23.050. ... antigens, cd55 MeSH D184.108.40.206.156 --- antigens, cd56 MeSH D220.127.116.11.157 --- antigens, cd57 MeSH D18.104.22.168.158 ... antigens, cd28 MeSH D22.214.171.1244.156 --- antigens, cd56 MeSH D126.96.36.1994.157 --- antigens, cd57 MeSH D188.8.131.520 ...
... such as PSAP and CD57. PSA was first identified by researchers attempting to find a substance in seminal fluid that would aid ... Prostate-specific antigen (PSA, also known as kallikrein III, seminin, semenogelase, γ-seminoprotein and P-30 antigen) is a 34- ... It is now clear that the term prostate-specific antigen is a misnomer: it is an antigen but is not specific to the prostate. ... In 1979, Wang purified a tissue-specific antigen from the prostate ('prostate antigen'). PSA was first measured quantitatively ...
"2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane ... and resolved infection and its relation with CD57". J. Immunol. 174 (10): 6088-94. doi:10.4049/jimmunol.174.10.6088. PMID ... 2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, ... "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". J ...
... to epithelial membrane antigen in 1 of 6 cases and muscle specific antigen in 1 of 6. Olgac et al. found that intense and ... CK7 and CD57 is better in this differential diagnosis. Differential diagnosis may be quite difficult indeed as exemplified by ...
A flavonoid sulfate antigen activates human ab CD8+ Th2 lymphocytes in pollen allergy. Eur J Immunol 2000, 30:964-968. ... CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006, 36:1892-1903. Macagno A, Molteni M, Rinaldi A, Bertoni F ... Sallusto F, Nicolò C, De Maria R, Corinti S, Testi R. Ceramide inhibits antigen uptake and presentation by dendritic cells. J ... Cella M, Salio M, Scheidegger D, Engering A, Pieters J, Sallusto F, Lanzavecchia A. Regulation of antigen capture, MHC ...
CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody - Mouse Monoclonal Antibody [Clone SPM527 ] IHC, IF - Buy Now! |Abgent
CD57 / B3GAT1 (Natural Killer Cell Marker) Antibody, Mouse Monoclonal Antibody [Clone SPM527 ] validated in IHC, IF (AH11298-7), Abgent
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CA 19-9, 1.0 ml. CA19-9, a carbohydrate epitope expressed on a high MW (| 400kDa) mucin glycoprotein, is a sialyl Lewis|sup|a|/sup| structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the
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Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. | JEM
Virtually all human granular lymphocytes expressed the HNK-1 differentiation antigen when examined in lymphoid compartments from adults, neonates, and fetuses. The HNK-1+ cells were distinguishable into three subsets having distinct antigenic phenotypes: HNK+T3-M1-, HNK+T3+M1-, and HNK+T3-M1+. Thus, greater than 70% of the HNK-1+ cells from 13-17 wk fetuses (less than 0.2% of nucleated cells) lacked T cell antigens (e.g., T3, T8, T4, and T6) and the M1 myeloid antigen. Morphologically, the HNK+T3-M1- cells consisted of three different types: small granular lymphocytes (less than 10% of HNK-1+ cells), agranular small lymphocytes with a narrow rim of cytoplasm (70-80%), and agranular giant cells (greater than 15 micrometers) with considerable neutrophilic cytoplasm (15%). The purified fetal HNK-1+ cells exhibited a low level of cytotoxicity against K562 target cells. On the other hand, almost all of HNK-1+ cells in neonatal tissues as well as adult bone marrow, lymph node, and thymus, exhibited ...
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Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. It involves both the hosts capacity to respond to infections and the development of long-term immune memory, especially by vaccination. This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time. It is considered a major contributory factor to the increased frequency of morbidity and mortality among the elderly. Immunosenescence is not a random deteriorative phenomenon, rather it appears to inversely repeat an evolutionary pattern and most of the parameters affected by immunosenescence appear to be under genetic control. Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. Immunosenescence is a multifactorial condition leading to many ...
Wed tidied up then gone to bed at ten. Miguel and I had talked for a bit, unable to sleep as we were both pretty pumped for the days ahead. We agreed that Miss Wilson (we assumed she wasnt married, which maybe wasnt fair) was going to be pretty hard on us, and we talked about the lives we were living behind. I mentioned the death of my father (I didnt mention that Id killed his killer- I figured I didnt need that news spreading any further than it already had), and Miguel told me his father was an officer in the UWAN. A major aboard a cruiser. I told him I thought that was cool- he told me it was actually quite stressful, never knowing if his mother and him would get word of a tragic battle.. Our conversation had slumped after that, though we did briefly argue over whether soccer should be called football. We also reminisced over our former girlfriends- Miguel had left behind not one but two broken hearts- dirty dawg!. After a little while the intensity of the day got to us. We settled ...
A CD4+ V(beta)13.6+ CD56+ large granular lymphocyte expansion with decreased expression of CD95 and an indolent clinical course...
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I am a female ,21 years old, 100 pounds 52. When I was born, my mother was told to watch me for a few days to see if I turned yellow. I didnt. My main concern is that I was recently to...
The CD15 antigen (Lewis x or Lex) is the lacto-N-(neo) fucopentaose III molecule. This carbohydrate epitope is carried by both glycolipids and glycoproteins expressed on the cell membrane. CD15 antigen is strongly expressed by neutrophils, eosinophils, monocytes, macrophages, mast cells and normal myeloid precursor cells. It is not expressed on normal erythrocytes, platelets or lymphocytes ...
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CD57 antigen | WAMES (Working for ME in Wales)
You are here: Home » Latest News » Archives for CD57 antigen. Tag Archives: CD57 antigen. Decreased expression of the CD57 ... Posted in News , Tagged biomarker, CD57 antigen, diagnostic marker, J M Urra, lymphocytes, Natural Killer cells, P Espinosa, ... Decreased Expression of the CD57 Molecule in T Lymphocytes of Patients with Chronic Fatigue Syndrome, by P Espinosa, J M Urra ...http://wames.org.uk/cms-english/tag/cd57-antigen/
O-glycosylation pattern of CD24 from mouse brain.
Antigens, CD24 / immunology, metabolism*. Antigens, CD57 / immunology. Brain*. Carbohydrate Sequence. Epitopes / immunology. ... 0/Antigens, CD24; 0/Antigens, CD57; 0/Epitopes; 0/Neural Cell Adhesion Molecule L1; 0/Polysaccharides; 0/Sugar Alcohols; 31103- ...http://www.biomedsearch.com/nih/O-glycosylation-pattern-CD24-from/19284289.html
Code System Concept
CD57 - Cluster of differentiation antigen 57 Current Synonym true false 1222559014 Cluster of differentiation antigen 57 ... Lymphocyte antigen CD57 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD57 (substance). ...https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=20764008
Your Immune Revolution & Healing Your Healing Power: Toru Abo MD, Kazuko Tatsumura Hillyer PhD: 9780970497925: Amazon.com: Books
He created monoclonal antibody against NK cell antigen CD57 while he attended Alabama University in 1980. In 1989, he ...https://www.amazon.com/Your-Immune-Revolution-Healing-Power/dp/097049792X
angiofollicular lymphoid hyperplasia hyaline vascular type 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chemical-registry-number] 0 / Antigens, CD57. * 51. Kaneko T, Ogushi T, Asakage Y, Kitamura T: [Hyaline vascular type of ... Chemical-registry-number] 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD20; 0 / Immunologic Factors; 4F4X42SYQ6 ...http://www.bmlsearch.com/?kwr=angiofollicular+lymphoid+hyperplasia+hyaline+vascular+type+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
WikiGenes - Leukoplakia, Oral
Immunolocalization of p53, glutathione S-tranferase pi and CD57 antigens in oral leukoplakia. De Paula, A.M., Gomez, R.S. ... Immunolocalization of p53, glutathione S-tranferase pi and CD57 antigens in oral leukoplakia . ... Immunohistochemical study of syndecan-1 down-regulation and the expression of p53 protein or Ki-67 antigen in oral leukoplakia ... evaluate a potential association between the loss of syndecan-1 expression and the expression of p53 protein and Ki-67 antigen ...https://www.wikigenes.org/e/mesh/e/6868.html
B3GAT1 - Wikipedia
... whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands ... CD57 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human B3GAT1 genome location and B3GAT1 ... "Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells". Blood. 101 (7): 2711-20 ... also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. In anatomical pathology, CD57 ...https://en.wikipedia.org/wiki/B3GAT1
"CD57 (Leu-7) expression is helpful in diagnosis of the follicular vari" by Ashraf Khan, Stephen P. Baker et al.
... is a oligosaccharide antigen that is expressed by cells of several lineages. It is present on multipotential neuroepithelial ... We observed CD57 positivity in 95% of thyroid carcinomas, 27% of follicular adenomas and 10% of colloid nodules. It was not ... CD57 expression in thyroid carcinomas was significantly different from that in normal and benign thyroid lesions (P , 0.0001). ... We have studied CD57 expression by immunohistochemistry to determine its utility in the classification of thyroid follicular ...https://escholarship.umassmed.edu/infoservices/54/
Sorted CD4+ T cell cytokine production.Cytokine product | Open-i
Antigens, CD57/metabolism*. *Cytokines/biosynthesis*. *Psoriasis/immunology/metabolism*. *Skin/immunology/metabolism*/pathology ... Bottom Line: CD57 is a marker of replicative inability and immunosenescence on CD8+ T cells and the proportion of CD57 ... Bottom Line: CD57 is a marker of replicative inability and immunosenescence on CD8+ T cells and the proportion of CD57 ... CD57 is a marker of replicative inability and immunosenescence on CD8+ T cells and the proportion of CD57 expressing CD8+ T ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585296_pone.0052144.g003&req=4
Expression of Leu-7 in myocardial sleeves around human pulmonary veins<...
keywords = "Adult, Aged, Aged, 80 and over, Atrial Fibrillation, CD57 Antigens, Cytoplasmic Granules, Female, Humans, ...https://research.vumc.nl/en/publications/expression-of-leu-7-in-myocardial-sleeves-around-human-pulmonary-
CD57 - Product: Leica Biosystems
Human lymph node: immunohistochemical staining for CD57 antigen using NCL-NK1. Note staining of CD57 positive T lymphocytes. ... Antigen Background The CD57 glycoprotein, also known as HNK-1, has a molecular weight of 110 kD.It is found on a subset of ... Many cells which co-express CD57 and CD8 proteins are a subset of suppressor/cytotoxic T cells. These cells play a role in the ...https://www.leicabiosystems.com/ihc-ish-fish/immunohistochemistry-ihc-antibodies-novocastra-reagents/primary-antibodies/products/cd57/
CD8+ CD57+ T Cell Isolation Kit, human - T cells - MicroBeads and Isolation Kits - Cell separation reagents - MACS Cell...
The CD57 antigen has been shown to be expressed on late-stage CD8 ... Expression of CD57 defines replicative senescence and antigen- ... CD57. + T Cell Isolation Kit and an LS Column in a MidiMACS™ Separator for the first positive selection, followed by the ... T Cell Isolation Kit was developed for the isolation of CD57. + cytotoxic T cells by sequential sorting from human PBMCs or ... CD57 expression is also increased on proliferation-incompentent or chronically activated CD8 ...https://www.miltenyibiotec.com/UN-en/products/macs-cell-separation/cell-separation-reagents/microbeads-and-isolation-kits/t-cells/cd8-cd57-t-cell-isolation-kit-human.html
researchimmune - The Hummingbirds' Foundation for M.E.
Natural killer cells as defined by CD16, CD56 and CD57 antigens were significantly reduced in CFS. A significant increase in ... High titers of antibodies to EBV, either IgG antiviral capsid antigen or anti-early antigen, can be demonstrated. In this study ... and activation antigens (CD38). Both the percentage and absolute numbers of CD4+ T cells bearing the CD45RA antigen appeared ... and activation antigens (CD38). Both the percentage and absolute numbers of CD4+ T cells bearing the CD45RA antigen appeared ...https://www.hfme.org/researchimmune.htm
Code System Concept
Lymphocyte positive for CD57 antigen (cell). Code System Preferred Concept Name. Lymphocyte positive for CD57 antigen (cell). ...https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=116855000
CD 57 antibody. *CD57 antibody. *CD57 antigen antibody. *Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1 ... Expansion of a unique CD57?NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.. Proc Natl Acad Sci ... 小鼠单克隆抗体[NK-1] to CD57 (PE/Cy5®) ...http://www.abcam.cn/cd57-antibody-nk-1-pecy5-ab25445.html
anlage tumor retinal 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Antigens, CD57 / analysis. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Biopsy, Needle. Diagnosis, ... Chemical-registry-number] 0 / Antigens, CD57; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic ... Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carcinoembryonic Antigen; 0 / Endothelin-3; 0 / MYC protein, human; 0 / ... Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Myogenin; 0 / Neoplasm Proteins; 68238-35 ...http://www.bmlsearch.com/?kwr=anlage+tumor+retinal+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
List of MeSH codes (D23) - Wikipedia
... antigens, cd55 MeSH D23.050.301.264.035.156 --- antigens, cd56 MeSH D23.050.301.264.035.157 --- antigens, cd57 MeSH D23.050. ... antigens, cd28 MeSH D23.050.301.264.894.156 --- antigens, cd56 MeSH D23.050.301.264.894.157 --- antigens, cd57 MeSH D23.050. ... antigens, cd55 MeSH D184.108.40.206.156 --- antigens, cd56 MeSH D220.127.116.11.157 --- antigens, cd57 MeSH D18.104.22.168.158 ... antigens, cd28 MeSH D22.214.171.1244.156 --- antigens, cd56 MeSH D126.96.36.1994.157 --- antigens, cd57 MeSH D188.8.131.520 ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
CD8+ CD57+ T Cell Isolation Kit, human - T cells - MicroBeads and Isolation Kits - Cell separation reagents - MACS Cell...
The CD57 antigen has been shown to be expressed on late-stage CD8 ... CD57. + target cells are magnetically labeled with CD57 ... CD57 antibodies, human. Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic ... ... CD57 antibodies, human. Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic ... ... CD57. + T Cell Isolation Kit and an LS Column in a MidiMACS™ Separator for the first positive selection, followed by the ...https://www.miltenyibiotec.com/BE-en/products/macs-cell-separation/cell-separation-reagents/microbeads-and-isolation-kits/t-cells/cd8-cd57-t-cell-isolation-kit-human.html
B3GAT1 monoclonal antibody, clone NK/804 - (MAB13284) - Products - Abnova
CD57 antigen,LEU7 antigen,UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase,beta-1,3-glucuronyltransferase 1, ... CD57,GLCATP,GlcAT-P,GlcUAT-P,HNK-1,HNK1,LEU7,NK-1 ... also known as CD57 and LEU7). Alternate transcriptional splice ...http://www.abnova.com/products/products_detail.asp?catalog_id=MAB13284
B3GAT1 monoclonal antibody, clone NK-1 (FITC) - (MAB6072) - Products - Abnova
CD57 antigen,LEU7 antigen,UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase,beta-1,3-glucuronyltransferase 1, ... A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).. Abo T, Balch CM.J Immunol. 1981 ... CD57+ T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses.. dAngeac AD, ... CD57,GLCATP,GlcAT-P,GlcUAT-P,HNK-1,HNK1,LEU7,NK-1 ... also known as CD57 and LEU7). Alternate transcriptional splice ...http://www.abnova.com/products/products_detail.asp?catalog_id=MAB6072
Frontiers | Melanoma Biomolecules: Independently Identified but Functionally Intertwined | Oncology
... the HNK-1 antigen (CD57), and β1-6 branched N-acetylglucosamine side-chains (β1-6 branches) (111) are among the carbohydrates ... analysis with monoclonal antibodies to tumor-associated antigens and to histocompatibility antigens. J Natl Cancer Inst (1983) ... High molecular weight-melanoma-associated antigen as a biomarker of desmoplastic melanoma. Pigment Cell Melanoma Res (2010) 23: ... Presence and prognostic significance of melanoma-associated antigens CYT-MAA and HMW-MAA in serum of patients with melanoma. J ...https://www.frontiersin.org/articles/10.3389/fonc.2013.00252/full
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While studying at Alabama University in 1980, he created "Leu-7," a monoclonal antibody against NK cell antigen CD57. He also ...http://www.babelpress.co.jp/shopdetail/000000000886/ct73/page1/order/
CD57-FITC - Beckman Coulter
The CD57 antigen (HNK-1 antigen carbohydrate moiety) is an oligosaccharide with sulfated glucoronic acid residues that may be ... Cord blood T cells or NK cells lack the CD57 antigen. It is not expressed on red blood cells or on platelets but is present on ... Many of these CD57+ cells co-express the CD8 antigen and are a subset of the suppressor / cytotoxic T lymphocytes. ...https://www.beckman.com.au/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/cd57/b49188
JCI - Evidence of premature immune aging in patients thymectomized during early childhood
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 101:2711-2720. ... D) Proportions of CD57+ cells within memory CD4+ or CD8+ T cells. (E) Correlation between naive and CD57+ memory CD4+ or CD8+ T ... Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells. Proc. Natl. Acad. Sci. U ... In contrast, antigen-driven expansion of memory CD4+ T cells is limited, and fewer CD4+ T cells are able to survive after ...https://www.jci.org/articles/view/39269
Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome |...
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003;101(7):2711- ... anti-CD57, and anti-Ki67 mAbs. Cells are gated for CD3+/CD4+ and CD3+/CD4+/CD57+ (left) or CD3+/CD8+ and CD3+/CD8+/CD57+/CD28− ... CD45RA+/CD57−), TEMRA (CD57+/CD28−/CD27−), and "DNT-like" (CD57+/CD28+/CD27+) cells and analyzed for their Ki67 expression (A) ... Therefore, we analyzed Ki67 expression in naive (CD45RA+/CD57−), terminal differentiated (TEMRA, CD57+/CD27−/CD28−), and "DNT- ...http://www.bloodjournal.org/content/128/2/227?sso-checked=true
- Although extensively cultured CTLs retain antigen specificity for the tumor ( 10 ), they present striking alterations in function and gene and protein expressions ( 8 ), e.g. they are in an irreversible cell cycle arrest, resistant to apoptosis, with short telomeres and unable to respond to antigenic cues or IL-2 stimulation. (mcponline.org)
- Many cells which co-express CD57 and CD8 proteins are a subset of suppressor/cytotoxic T cells. (leicabiosystems.com)
- In most, but not all, animal models of adaptive immune responses to viral infection, optimal clearance of virus depends on synergistic interactions between antigen-specific populations of helper CD4 + T cells, antibody-producing B cells, and cytotoxic CD8 + T cells. (bloodjournal.org)
- We have studied CD57 expression by immunohistochemistry to determine its utility in the classification of thyroid follicular lesions. (umassmed.edu)
- We conclude that CD57 immunohistochemistry is valuable in the classification of thyroid follicular lesions into benign and malignant groups and is also helpful in the diagnosis of the follicular variant of papillary thyroid carcinoma. (umassmed.edu)
- There is an increase in the number of circulating CD57 positive cells in the blood of patients who have recently undergone organ or tissue transplants, especially of the bone marrow, and in patients with HIV. (wikipedia.org)
- Neoplastic CD57 positive cells are seen in conditions as varied as large granular lymphocytic leukaemia, small-cell carcinoma, thyroid carcinoma, and neural and carcinoid tumours. (wikipedia.org)
- It is present on multipotential neuroepithelial cells during embryogenesis, and tumours of epithelial, neuroectodermal and nerve sheath origin also express CD57. (umassmed.edu)
- CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. (nih.gov)
- We examined the expression of CD57 on T cells in the skin of patients affected with psoriasis, comparing lesional and unaffected skin. (nih.gov)
- We observed that the frequency of CD57+CD4+ and CD57+CD8+ T cells was significantly higher in unaffected skin of psoriasis patients compared to lesional skin. (nih.gov)
- The CD57 glycoprotein, also known as HNK-1, has a molecular weight of 110 kD.It is found on a subset of mononuclear cells with natural killer activity and on neuroectodermal cells expressing myelin-associated glycoprotein. (leicabiosystems.com)
- A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). (abnova.com)
- Cord blood T cells or NK cells lack the CD57 antigen. (beckman.com.au)
- We investigated whether HIV-1 antigen-specific CD4 + T cells expressed the viral coreceptor CCR5 during primary HIV-1 infection (PHI). (bloodjournal.org)
- However, in PHI subjects with later presentation, antigen-specific CD4 + T cells could not be readily detected (median, 0.08%), coinciding with a 5-fold lower level of the CCR5 + CD38 +++ CD4 + T cells. (bloodjournal.org)
- Antigen-specific memory CD4 + T cells are not often found in untreated chronic HIV-1 infection, using the standard in vitro proliferation assay. (bloodjournal.org)
- 5 This deficit of antigen-specific CD4 + T cells may represent a major impediment to immune control of HIV-1 infection. (bloodjournal.org)
- These results suggest that antigen-specific CD4 + T cells should be generated at a relatively high level during primary HIV-1 infection. (bloodjournal.org)
- Interferon (IFN)-γ producing antigen-specific CD4 + T cells have been demonstrated in primary HIV-1 infection, despite high levels of viremia. (bloodjournal.org)
- 13 , 14 , 18 Further evidence for the presence of antigen-specific CD4 T cells is the production of high-affinity, isotype-switched antibodies to HIV-1, which presumably requires the provision of help for B-cell responses by CXCR5 + CD4 + follicular helper T cells. (bloodjournal.org)
- Although CD4 + T cells that proliferate in vitro in response to HIV-1 antigens are mostly absent in untreated chronically infected subjects, an average of approximately 0.1% of peripheral blood CD4 + T cells capable of producing IFN-γ can be detected in most HIV-infected individuals by enzyme-linked immunospot (ELISPOT) assay or by intracellular cytokine assay. (bloodjournal.org)
- Cells derived from aged cancer patients have a skewed immune repertoire toward cells that underwent extensive clonal expansion against persistent antigens, resulting in few tumor-specific CTLs ( 6 - 8 ). (mcponline.org)
- The frequency (0.088-3.9% of CD3(+)CD8(+) cells) and phenotype (CD27(+)CD28(-), CD45RA(+/-), CD57(+/-), HLA-DR(+), CD95(+)) of infant HIV-specific CD8(+) T cells were similar to reports in adults undergoing early infection. (ox.ac.uk)
- Human lymph node: immunohistochemical staining for CD57 antigen using NCL-NK1. (leicabiosystems.com)
- We report that CD8 + T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)-B27 patients. (rupress.org)
- This article examines accelerated aging in HIV disease as an activation-induced inflammatory condition that is a consequence of optimal or suboptimal inflammation and activation due to antigen- (infectious or noninfectious HIV) driven injury that occurs over the lifetime, rather than just a complex group of diseases or morbidities associated with age or HIV infection. (pubmedcentralcanada.ca)