Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Diverticulitis: Inflammation of a DIVERTICULUM or diverticula.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Lung Neoplasms: Tumors or cancer of the LUNG.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Small Cell Lung Carcinoma: A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Neural Cell Adhesion Molecules: Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)Neural Cell Adhesion Molecule L1: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Sialic Acids: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Cell Adhesion: Adherence of cells to surfaces or to other cells.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Leukocyte L1 Antigen Complex: A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.Maytansine: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Immunoconjugates: Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Mesocricetus: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Immunotoxins: Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Immunotherapy: Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.Nerve Sheath Neoplasms: Neoplasms which arise from nerve sheaths formed by SCHWANN CELLS in the PERIPHERAL NERVOUS SYSTEM or by OLIGODENDROCYTES in the CENTRAL NERVOUS SYSTEM. Malignant peripheral nerve sheath tumors, NEUROFIBROMA, and NEURILEMMOMA are relatively common tumors in this category.Neurofibrosarcoma: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).Neurofibroma: A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)Peripheral Nervous System Neoplasms: Neoplasms which arise from peripheral nerve tissue. This includes NEUROFIBROMAS; SCHWANNOMAS; GRANULAR CELL TUMORS; and malignant peripheral NERVE SHEATH NEOPLASMS. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp1750-1)Neurilemmoma: A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)Neurofibroma, Plexiform: A type of neurofibroma manifesting as a diffuse overgrowth of subcutaneous tissue, usually involving the face, scalp, neck, and chest but occasionally occurring in the abdomen or pelvis. The tumors tend to progress, and may extend along nerve roots to eventually involve the spinal roots and spinal cord. This process is almost always a manifestation of NEUROFIBROMATOSIS 1. (From Adams et al., Principles of Neurology, 6th ed, p1016; J Pediatr 1997 Nov;131(5):678-82)Genes, Neurofibromatosis 1: Tumor suppressor genes located on the long arm of human chromosome 17 in the region 17q11.2. Mutation of these genes is thought to cause NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome.Neurofibromin 1: A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Distinct clinical and laboratory activity of two recombinant interleukin-2 preparations. (1/766)

Interleukin-2 (IL-2) is a potent lymphokine that activates natural killer cells, T cells, and other cells of the immune system. Several distinct recombinant human IL-2 preparations have shown antitumor activity, particularly for renal cell cancer and melanoma. Somewhat distinct immune and clinical effects have been noted when different IL-2 preparations have been tested clinically; however, the regimens and doses used were not identical. To compare these more directly, we have evaluated two clinical recombinant IL-2 preparations in vitro and in vivo using similar regimens and similar IUs of IL-2. We used the Food and Drug Administration-approved, commercially available Chiron IL-2 and the Hoffmann LaRoche (HLR) IL-2 supplied by the National Cancer Institute. Using equivalent IUs of IL-2, we noted quantitative differences in vitro and in vivo in the IL-2 activity of these two preparations. In patients receiving comparable IUs of the two preparations, HLR IL-2 induced the release of more soluble IL-2 receptor alpha into the serum than Chiron IL-2. In addition, more toxicities were noted in patients receiving 1.5 x 10(6) IU of HLR IL-2 than were seen in patients treated with 1.5 x 10(6) or even 4.5 x 10(6) IU of Chiron IL-2. These toxicities included fever, nausea and vomiting, and hepatic toxicity. In vitro proliferative assays using IL-2-dependent human and murine cell lines indicated that the IU of HLR IL-2 was more effective than Chiron IL-2 at inducing tritiated thymidine incorporation. Using flow cytometry, we also found quantitative differences in the ability of these two preparations to bind to IL-2 receptors. These findings indicate that approximately 3-6 IU of Chiron IL-2 are required to induce the same biological effect as 1 IU of HLR IL-2.  (+info)

Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. (2/766)

Fetal CD34(+) CD38(+) cells have recently been found to persist in maternal peripheral blood for many years after pregnancy. CD34(+) CD38(+) cells are progenitor cells that can differentiate into mature immune-competent cells. We asked whether long-term fetal microchimerism occurs in T lymphocyte, B lymphocyte, monocyte, and natural-killer cell populations of previously pregnant women. We targeted women with sons and used polymerase chain reaction for a Y-chromosome-specific sequence to test DNA extracted from peripheral blood mononuclear cells (PBMC) and from CD3, CD19, CD14, and CD56/16 sorted subsets. We also asked whether persistent microchimerism might contribute to subsequent autoimmune disease in the mother and included women with the autoimmune disease scleroderma. Scleroderma has a peak incidence in women after childbearing years and has clinical similarities to chronic graft-versus-host disease that occurs after allogeneic hematopoietic stem-cell transplantation, known to involve chimerism. Sixty-eight parous women were studied for male DNA in PBMC and 20 for PBMC subsets. Microchimerism was found in PBMC from 33% (16 of 48) of healthy women and 60% (12 of 20) women with scleroderma, P =.046. Microchimerism was found in some women in CD3, CD19, CD14, and CD56/16 subsets including up to 38 years after pregnancy. Microchimerism in PBMC subsets was not appreciably more frequent in scleroderma patients than in healthy controls. Overall, microchimerism was found in CD3, CD19, and CD14 subsets in approximately one third of women and in CD56/16 in one half of women. HLA typing of mothers and sons indicated that HLA compatibility was not a requirement for persistent microchimerism in PBMC subsets. Fetal microchimerism in the face of HLA disparity implies that specific maternal immunoregulatory pathways exist that permit persistence but prevent effector function of these cells in normal women. Although microchimerism in PBMC was more frequent in women with scleroderma than healthy controls additional studies will be necessary to determine whether microchimerism plays a role in the pathogenesis of this or other autoimmune diseases.  (+info)

Phenotypic analysis and proliferative responses of human endometrial granulated lymphocytes during the menstrual cycle. (3/766)

The in vivo function of the unusual population of CD56+ CD16- endometrial granulated lymphocytes (eGLs) in human endometrium is unknown; their increased numbers in the secretory phase of the menstrual cycle suggests that they may play a role in the immunobiology of nonpregnant endometrium. In the present study, the phenotype and proliferative responses of eGLs at various phases of the menstrual cycle were compared with those in early pregnancy. Endometrial GLs were highly purified (> 98% CD56+) using immunomagnetic separation, and the expression of cell surface antigens was examined in smears using a double immunohistochemical labeling technique. Proliferative responses to mitogens and interleukin 2 (IL-2) were assessed in hanging drops in 60-well Terasaki plates. There was low to no expression of CD3, CD8, CD16, HML-1, L-selectin, and CD25 (IL-2 receptor alpha) on CD56+ cells isolated from nonpregnant and pregnant endometrium. The expression of CD2, CD49a, and CD122 (IL-2 receptor beta, IL-2Rbeta), however, increased from the proliferative to the late secretory phase of the menstrual cycle. In contrast, CD11a, CD69, and CD49d expression was high and did not vary with menstrual cycle phase; CD49d levels were significantly reduced in early pregnancy. Unlike early-pregnancy eGLs, none of the CD56+ eGL cultures throughout the menstrual cycle displayed phytohaemagglutinin (PHA)-induced lymphoproliferation. In contrast, eGLs from nonpregnant endometrium in the presence of 5 or 100 U/ml IL-2 after 48- and 120-h incubation showed significant proliferative responses, as did eGL cultures from early pregnancy. A significantly reduced number of proliferative phase eGL cultures proliferated in response to IL-2 compared to secretory phase and early-pregnancy eGL cultures. The IL-2-induced proliferative responses of CD56+ eGLs were associated with increased IL-2Rbeta (CD122) expression. These findings demonstrate 1) differential eGL expression of CD2, CD49a, and CD122 during the menstrual cycle; 2) differential IL-2-induced eGL proliferative responses during the menstrual cycle; and 3) differences between eGLs from nonpregnant and pregnant endometrium in CD49d expression and their ability to respond to PHA.  (+info)

Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals. (4/766)

Dysfunction of cytotoxic activity of T and natural killer (NK) lymphocytes is a main immunological feature in patients with AIDS, but its basis are not well understood. It has been recently described that T and NK cell-mediated cytotoxicity can be regulated by HLA killer inhibitory receptors (KIR). In this work, we have determined on cytotoxic T cells and NK cells from HIV-1-infected individuals the expression of the following KIR molecules: p58, p70, and ILT2 (immunoglobulin-like family KIR) as well as CD94 and NKG2A (C-lectin-type family KIR). With some exceptions, no significant changes were found on the expression of immunoglobulin-like KIR in either CD8+ or CD56+ cells. Interestingly, the percentages of CD8+ and CD56+ cells expressing CD94 were significantly increased in these individuals. We also show that, in vitro, IL-10 up-regulates CD94 expression on CD8+ and CD56+ cells obtained from normal individuals, suggesting that the augmented expression observed in HIV-infected individuals could be related to the high levels of IL-10 previously described in HIV-1-infected individuals.  (+info)

Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. (5/766)

NK cells constitutively express monocyte-derived cytokine (monokine) receptors and secrete cytokines and chemokines following monokine stimulation, and are therefore a critical component of the innate immune response to infection. Here we compared the effects of three monokines (IL-18, IL-15, and IL-12) on human NK cell cytokine and chemokine production. IL-18, IL-15, or IL-12 alone did not stimulate significant cytokine or chemokine production in resting NK cells. The combination of IL-18 and IL-12 induced extremely high amounts of IFN-gamma protein (225 +/- 52 ng/ml) and a 1393 +/- 643-fold increase in IFN-gamma gene expression over those in resting NK cells. IL-15 and IL-12 induced less IFN-gamma protein (24 +/- 10 ng/ml; p < 0.007) and only a 45 +/- 19-fold increase in IFN-gamma gene expression over those in resting NK cells. The CD56bright NK cell subset produced significantly more IFN-gamma following IL-18 and IL-12 compared with CD56dim NK cells (p < 0.008). However, the combination of IL-15 and IL-12 was significantly more potent than that of IL-18 and IL-12 for NK cell production of IL-10, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and TNF-alpha at the protein and transcript levels. Granulocyte-macrophage CSF was optimally induced by IL-15 and IL-18. Resting CD56+ NK cells expressed IL-18R transcript that was up-regulated by IL-12 or IL-15. Our results show that distinct cytokine and chemokine patterns are induced in NK cells in response to different costimulatory signals from these three monokines. This suggests that NK cell cytokine production may be governed in part by the monokine milieu induced during the early proinflammatory response to infection and by the subset of NK cells present at the site of inflammation.  (+info)

Co-stimulation of human decidual natural killer cells by interleukin-2 and stromal cells. (6/766)

At the late secretory phase of the menstrual cycle and in early pregnancy, the uterine mucosa is infiltrated by large numbers of natural killer (NK) cells with a distinctive phenotype (CD56bright CD16- CD3-) and large granular lymphocyte (LGL) morphology. Circulating CD56bright NK cells generally proliferate in the presence of interleukin-2 (IL-2), but it is clear that cofactors besides IL-2 are required for optimal response. In the bone marrow, this co-stimulating signal is provided by stromal cells. In the present study we observe that uterine CD56+ cells from early pregnancy decidua similarly proliferate vigorously when cultured with decidual stromal cells and a suboptimal dose of IL-2. This response is dependent on cell-cell contact, as no proliferation of decidual NK cells was observed when they were separated from stromal cells by a permeable cyclopore membrane. In addition, we have studied the expression of Bcl-2 by decidual CD56+ cells. Our results show that the microenvironment of the uterus is likely to have a significant influence on the proliferation and survival of uterine CD56+ cells.  (+info)

Apoptosis of human endometrium mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes. (7/766)

Endometrial stromal granulocytes (EGs) were found to be a major component of human endometrial stroma in the late secretory phase. However, the role of EGs in the mechanism of human endometrial menstruation has not been clarified. Immunohistochemistry of CD56, perforin, granzyme B, and vimentin, in situ detection of apoptosis by TUNEL (TdT-mediated dUTP-biotin nick and labeling) and electron microscopy were performed in endometrial tissue samples with normal menstrual cycles. We analyzed the number of immunostained cells in the functional layer of stroma and the number of apoptotic cells detected by TUNEL in the endometrial glandular cells. Double-staining revealed that CD56-positive endometrial stromal cells were simultaneously positive for both perforin and granzyme B, and negative for vimentin, which recognized stromal tissue. Vimentin was positive for the predecidual cells and negative for EGs. CD56-positive EGs involving perforin and granzyme B were progressively recruited during the secretory phases before menstruation. Apoptosis in endometrial glandular cells increased from the late secretory phase, which maximized at the menstrual period. This finding suggests that the cytotoxic granules released from EGs, which are derived from cytotoxic T lymphocytes and natural killer cells, are initiators of the apoptotic pathway that induces endometrial menstruation.  (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (8/766)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important.  (+info)

*Plasma cell leukemia

17%); pPCL plasma cells often lack CD56 antigen which is present on the majority of plasma cells taken form multiple myeloma ... For example: pPCL plasma cells more often express CD20 antigen, which is considered important in anchoring plasma cells to the ... Examination of plasma cell immunophenotype by measuring certain of their cell surface antigens, particularly Cluster of ...

*NK-92

... cells are a very close match with blood NK cells: they express on their surface the characteristic CD56 antigen and are ... Chimeric Antigen Receptor (CAR) engineered T-lymphocytes are currently the buzz in Immuno-Oncology, having shown that infusion ... Porter DL, Levine BL, Kalos M, Bagg A, June CH (August 2011). "Chimeric antigen receptor-modified T cells in chronic lymphoid ... therapy in hematological malignancies and lung cancer for local intra-tumor injection as effector cells for chimeric antigen ...

*List of MeSH codes (D12.776.395)

... antigens, cd56 MeSH D12.776.395.550.200.250.520.578 -- neural cell adhesion molecule l1 MeSH D12.776.395.550.200.275 -- ... antigens, cd22 MeSH D12.776.395.550.200.098 -- antigens, cd24 MeSH D12.776.395.550.200.131 -- antigens, cd31 MeSH D12.776. ... 395.550.200.170 -- antigens, cd146 MeSH D12.776.395.550.200.175 -- antigens, cd164 MeSH D12.776.395.550.200.200 -- cadherins ... antigens, cd43 MeSH D12.776.395.560.631.650.264 -- antigens, cd164. ...

*List of MeSH codes (D23)

... antigens, cd47 MeSH D23.050.301.264.035.155 --- antigens, cd55 MeSH D23.050.301.264.035.156 --- antigens, cd56 MeSH D23.050. ... antigens, cd27 MeSH D23.050.301.264.894.128 --- antigens, cd28 MeSH D23.050.301.264.894.156 --- antigens, cd56 MeSH D23.050. ... antigens, cd47 MeSH D23.101.100.110.155 --- antigens, cd55 MeSH D23.101.100.110.156 --- antigens, cd56 MeSH D23.101.100.110.157 ... antigens, cd27 MeSH D23.101.100.894.128 --- antigens, cd28 MeSH D23.101.100.894.156 --- antigens, cd56 MeSH D23.101.100.894.157 ...

*List of MeSH codes (D12.776.543)

... antigens, cd56 MeSH D12.776.543.550.200.250.520.578 -- neural cell adhesion molecule l1 MeSH D12.776.543.550.200.275 -- ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 -- antigens, cd79 MeSH D12.776.543.750.705.816.824 -- receptors, antigen, ... antigens, cd22 MeSH D12.776.543.550.200.124 -- antigens, cd24 MeSH D12.776.543.550.200.131 -- antigens, cd31 MeSH D12.776. ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 -- antigens, cd30 MeSH D12.776.543.750.705.852.760.097 -- antigens, cd40 ...

*Fetal rhabdomyoma

... epithelial membrane antigen, CD68, FLI1, CD99 and CD56. Although not used as frequently now, electron microscopy will show ...

*Papillary tumors of the pineal region

CD56/N-CAM (neural cell adhesion molecule) → ++ S100 → ++ Transthyretin → - Vimentin → +++ Desmin → - SMA (smooth muscle actin ... epithelial membrane antigen) → - GFAP (glial fibrillary acidic protein) → + Synaptophysin → - Chromogranin → - NSE (neuron- ...

*Neuroendocrine differentiation

They are negative for androgen receptor and prostate-specific antigen (PSA) and are positive for prostate acid phosphatase. ... Immunohistochemically, prostatic small cell carcinoma are positive for thyroid transcription factor 1 (TTF-1), CD56, ... androgen receptor and prostate-specific antigen. It is commonly believed that prostatic adenocarcinoma exhibiting significant ...

*Natural killer cell

Infusions of T cells engineered to express a chimeric antigen receptor that recognizes an antigen molecule on leukemia cells ... and CD56 in humans, NK1.1 or NK1.2 in C57BL/6 mice. The NKp46 cell surface marker constitutes, at the moment, another NK cell ... which subsequently enables antigen-specific T and B cell responses. Instead of acting via antigen-specific receptors, lysis of ... In contrast to NKT cells, NK cells do not express T-cell antigen receptors (TCR) or pan T marker CD3 or surface immunoglobulins ...

*Lymphopoiesis

CD56 bright' is chiefly responsible for cytokine production and has enhanced survival. Traveling to lymph nodes the 'CD56 ... Once in a secondary lymphoid organ the B cell can be introduced to an antigen that it is able to recognize. Through this ... Human NK T cells are a unique population (which express NK cell markers such as CD56 and KIR). NKT cells are thought to play an ... T cells are formed in bone marrow then migrate to the cortex of the thymus to undergo maturation in an antigen-free environment ...

*B3GAT1

Although the antigen is particularly common in carcinoid tumours, it is found in such a wide range of other conditions that it ... In anatomical pathology, CD57 (immunostaining) is similar to CD56 for use in differentiating neuroendocrine tumors from others ... CD57 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human B3GAT1 genome location and B3GAT1 ... In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or ...

*Lineage markers

Certain antibodies can be used to detect or purify cells with these markers by binding to their surface antigens. A standard ... and CD56 (NK cells) in humans. "Lineage Markers". Retrieved 12 July 2013. ...

*Multiple myeloma

However, this antigen disappears rapidly ex vivo. Recently, however, it was discovered that the surface antigen CD319 (SLAMF7) ... myeloma cells are typically CD56, CD38, CD138, CD319 positive and CD19 and CD45 negative.[citation needed] Cytogenetics may ...

*Natural killer T cell

iNKT cells recognize lipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like antigen ... Natural killer T cells can share other features with NK cells, as well, such as CD16 and CD56 expression and granzyme ... which is specific for glycolipid antigens. The best known antigen of iNKT cells is α-galactosylceramide(αGalCer), which is a ... Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self and foreign ...

*CD90

It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in ... This locus is very close to CD3 & CD56/NCAM genes. Some believe that there may be a functional significance of both this gene ... The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search ... "The AKR thymic antigen and its distribution in leukemias and nervous tissue". J. Exp. Med. 120: 413-433. doi:10.1084/jem.120.3. ...

*CD160

... antigen is a protein that in humans is encoded by the CD160 gene. CD160 is a 27 kDa glycoprotein which was initially ... CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad ... CD160 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD160 genome location and CD160 gene ...

*Stem cell marker

CK19, Cytokeratin 19, K19) Kit L-selectin (CD62L) Lamin A/C Lewis X antigen (Le(X)) LeX Lgr5 Lrp4 MCM2 MCSP Metallothionein (MT ... CD56) CD73 CD9 CD90 CDCP1 Circulating anticoagulants protein C (PC) CK19 CLV3 cyclic CMP ECMA-7 EDR1 EEC FGF-4 Flk-2 Flk1(+) ... May 2006). "Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell ... Muramatsu T, Muramatsu H (2004). "Carbohydrate antigens expressed on stem cells and early embryonic cells". Glycoconjugate ...

*KIR3DL2

Goodier MR, Londei M (2000). "Lipopolysaccharide stimulates the proliferation of human CD56+CD3- NK cells: a regulatory role of ... 2005). "Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2". Tissue Antigens. 64 (3): 226-34. ... Tissue Antigens. 68 (3): 220-4. doi:10.1111/j.1399-0039.2006.00651.x. PMID 16948642. Ortonne N, Bagot M, Bensussan A (2006). "[ ... Tissue Antigens. 70 (3): 228-32. doi:10.1111/j.1399-0039.2007.00880.x. PMID 17661911. This article incorporates text from the ...
FIGURE 2. The ontogeny of CD56+ NK cell subsets: the traditional model with recent alternatives. There seemed to be a consensus that NK cells originate via a linear differentiation model. Hematopoietic stem cells (HSCs) differentiate into CLPs, and then into CD56bright NK cells, and eventually into CD56dim NK cells. The last step probably involves minichromosome maintenance 4 (MCM4). Nevertheless, CD56dim cells are also able to upregulate CD56 after activation, suggesting that a proportion of CD56bright NK cells might not be precursors but activated cells. However, recent research seems to challenge this traditional model. It was proposed that CD56dim NK cells may also derive directly from CLPs and that common myeloid progenitors (CMPs) may also be precursors for CD56bright NK cells. Finally, an additional argument is raised suggesting an ontogenic independency of these two subsets of NK cells, because mutated GATA-2 suppresses the CD56bright, but not the CD56dim, population. ...
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THU0032 Selective, Autoantibody-Immune Complex Mediated Proportional and Functional Changes of Specific NK-Cell Subsets in Early Seropositive but not Seronegative Rheumatoid Arthritis ...
Impaired immune regulatory function of natural killer (NK) cells in multiple sclerosis (MS). 10:02 Andreas Schulte-Mecklenbeck (010) CD56brightCD16-/dim NK cells exhibit enhanced migratory ca- pacity across the blood brain barrier and are the major in- trathecal NK cell subset. 10:15 Dejene M. Tufa (011 ...
Proteome Analysis of Distinct Developmental Stages of Human Natural Killer Cells The recent Natural Killer (NK) cell maturation model postulates that CD34+ hematopoietic stem cells (HSC) first develop into CD56bright NK cells, then into CD56dimCD57− and finally into terminally maturated CD56dimCD57+. The molecular mechanisms of human NK cell differentiation and maturation however are incompletely characterized. Here we present a proteome analysis of distinct developmental stages of human primary NK cells, isolated from healthy human blood donors. Peptide sequencing was used to comparatively analyze CD56bright NK cells versus CD56dim NK cells and CD56dimCD57− NK cells versus CD56dimCD57+ NK cells and revealed distinct protein signatures for all of these subsets. Quantitative data for about 3400 proteins were obtained and support the current differentiation model. Furthermore, 11 donor-independently, but developmental stage specifically regulated proteins so far un-described in NK cells were ...
Natural killer cells respond to stimulation with autologous iCD4. By using fluorochrome conjugated antibody panels it is possible to gate on NK cell populations expressing defined inhibitory NKRs (iNKR) and to detect anti-viral functions such as secretion of IFN-γ/CCL4 and expression of CD107a by flow cytometry. This strategy has been used to explore the factors governing how NK cells from HIV-uninfected persons respond to their first encounter with autologous iCD4.. NKG2A/CD94 is an iNKR expressed on almost all CD56bright and on ~40% of CD56dim NK cells. The ligand for NKG2A in HLA-E, a non-classical MHC-Ib antigen whose cell surface expression depends on binding highly conserved peptides from the leader sequence of many HLA-A, B, C and G MHC-I molecules [19]. HLA-E is expressed on many cell types and maintained on iCD4 [20]. As NKG2A is an iNKR, the interaction of NKG2A with HLA-E on iCD4 should inhibit NK cell activation. However, the highest frequency of functional NK cells induced by ...
Granularity is a characteristic of both dNK and CD56dim pNK cells, both of which are also called large granular lymphocytes (65), whereas CD56bright pNK cells are known to be less granular (15). Granzyme B and perforin (components of cytotoxic granules) were expressed at similar levels in dNK and CD56dim pNK cells, whereas granzyme A was 3- and 10-fold overexpressed in dNK cells versus the CD56dim and CD56bright pNK cells, respectively (Fig. 3 C). Thus, the potential cytolytic function of dNK cells, probably regulated, cannot be ignored. This nascent activity could be manifest in the decidua under special circumstances (e.g., virus infection of the trophoblast or decidual remodeling).. Many other genes overexpressed in dNK cells that are presented in Fig. 3 (e.g., CD31, CD38, MIP-1 α/β, Syk, LEF1, AARS, arp2/3 subunit, and tubulins) may be of considerable interest but are beyond the scope of the present paper. Likewise, genes that are absent or have lower expression in dNK cells in relation to ...
TY - JOUR. T1 - Characterization of Cord Blood Natural Killer and Lymphokine Activated Killer Lymphocytes Following Ex Vivo Cellular Engineering. AU - Ayello, Janet. AU - van de Ven, Carmella. AU - Fortino, Weiwei. AU - Wade-Harris, Cheryl. AU - Satwani, Prakash. AU - Baxi, Laxmi. AU - Simpson, Lynn L.. AU - Sanger, Warren G. AU - Pickering, Diana. AU - Kurtzberg, Joanne. AU - Cairo, Mitchell S.. PY - 2006/6/1. Y1 - 2006/6/1. N2 - Cord blood (CB) natural killer (NK) and lymphokine-activated killer (LAK) cytotoxic cells are poorly characterized but might be used to treat minimal residual and/or recurrent malignant disease. Currently, there is no mechanism to use CB for adoptive cancer cellular immunotherapy after CB transplantation (CBT). Recognizing this as a deficiency, we hypothesized that CB aliquots could be engineered ex vivo for potential donor lymphocyte infusion after CBT. Cryopreserved CB aliquots were thawed, depleted of monocytes, and cultured in serum-free medium alone or serum-free ...
Malignancies arising from cells of putative natural killer (NK) cell origin have increasingly been recognized as distinct clinicopathological entities. These malignancies are marked by tumour cells with NK cell characteristics, including the immunophenotype of CD2+, surface CD3-, cytoplasmic CD3ε+, CD7 ±, and CD56+, and the genotype of germline T cell receptor gene. A consistent association with monoclonal Epstein-Barr virus infection in the tumour cell has been observed. These tumours are now regarded as putative NK cell lymphoma/leukemia. Pathologically, tumour cells show variable cytological appearances, with frequent angiocentricity and angioinvasion, associated with zonal necrosis. Clinically, most cases occur in the nasal area and upper aerodigestive tract. However, occurrence in non- nasal sites such as the skin, gastrointestinal tract and testis is also observed. A particularly aggressive form of NK lymphoma/leukemia presents fulminantly as disseminated disease sometimes with a ...
treatment add-ons, you may be interested in some impartial and expert advice in two new scientific opinion papers published by the Royal College of Obstetricians and Gynaecologists (RCOG). They call for more high quality research into the role of natural killer cells in fertility and the effect of endometrial scratching on pregnancy outcomes.. Scientific Impact Papers (SIP), are up-to-date reviews of emerging or controversial scientific issues. The first paper looks at the role of uterine natural killer (uNK) cells, how they are measured, the role of testing and the evidence behind any links to improving implantation rates and early placental development. The paper clarifies that uNK cells are completely different from peripheral blood natural killer cells (which you would be testing in the blood tests some fertility clinics currently offer).. The paper makes it clear that there is no evidence to offer routine tests for NK cells as part of fertility treatment or testing, and that there is ...
Natural Killer Cells are the most aggressive white cells in the immune system. They make up about 5% to 15% of the total lymphocyte circulating population. They target tumor cell and protect against a wide variety of infectious microbes. Natural Killer Cells are a very important factor in the fight against cancer. Immune Stimulation is the key to keeping the white blood cell count high and giving the Natural Killer Cells a chance to fight cancer and other diseases.. ...
Publications Peer-reviewed publications Guidelines for the use of flow cytometry and cell sorting in immunological studies. Cossarizza A ... Fehniger TA ...Zimmermann J [100 Authors]. Eur J Immunol. 2017 Oct;47(10):158401797. CD56bright NK Cells Exhibit Potent Antitumor Responses Following IL-15 Priming Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell…
Natural killer (NK) cells comprise 5-20% of peripheral blood mononuclear cells (PBMC) in humans. In addition to their fundamental roles in the defense against viral infections and tumor surveillance, NK cells help shape adaptive immune responses through their production of cytokines. NK cells are traditionally identified as CD3neg, CD14neg, CD19neg lymphocytes expressing CD56. Using a combination of markers that includes CD56 and CD7 greatly increases the ability to define the phenotype and function of NK cell subsets. Two key markers of NK cell function are the production of IFNγ and the release of cytotoxic granules measured by the expression of CD107a. Here we describe a method to assess IFNγ and CD107a expression in NK cells following stimulation with target cells or cytokines. This method can be used to assess the general functional capacity of NK cells in peripheral blood mononuclear cells from a wide range of study participants.
Brunda, M J.; Taramelli, D; Holden, H T.; and Varesio, L, "Effects of resting and activated macrophages on natural killer cell activity and lymphoproliferation. Abstr." (1981). Subject Strain Bibliography 1981. 551 ...
Natural Killer Cells are also defined as large granular lymphocytes (LGL) and comprise the third kind of cells other than B and T Lymphocytes. They usually...
New research out of the Raulet lab suggests a mechanism explaining why Natural Killer cells are sometimes rendered ineffective, and even more excitingly, suggests a therapeutic approach for re-awakening them to attack tumors. Read more...
Researchers observed a marked increase in natural killer cells in HIV - positive children receiving massage therapy than those who did not receive massage. Natural killer cells are unique in that they attack only cells infected by a microbe. The children who did not receive massage had a steady decrease of these important immune cells, while those receiving treatment either remained stable or had an increase in natural killer cells ...
Vladimir V. Senyukov is the author of this article in the Journal of Visualized Experiments: Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells
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CD337, also known as NKp30, is a 30-kDa transmembrane glycoprotein which is a NK-specific triggering receptor involved in non-MHC-restricted natural cytotoxicity. NKp30 is strictly expressed by all resting and activated NK cells including the minor CD3-CD56brightCD16- subset. With NKp46 and NKp44 it is one of the three identified NK natural cytotoxicity receptors (NCR). Its surface expression parallels that of NKp46. NKp46dull NK cells are also characterised by a NKp30dull phenotype while NKp46bright NK cells show a NKp30bright phenotype. The NKp30bright or NKp30dull phenotypes are correlated with high or low cytotoxicity, respectively. CD337 is a member of the immunoglobulin superfamily characterized by a single extracellular V-type Ig-like domain. It is associated with a homodimer of ITAM motif-containing CD3ζ adaptor proteins. These adaptor proteins are not necessary for surface expression of NKp30, but are necessary for signal transduction. In redirected killing assays, Z25-mediated cross ...
0072]While the CD34+ cells, CD31+CD34brightCD45dimAC133+ CHSPCs or CD31+CD34brightCD45dimAC133- CHSPCs all showed substantially similar rates of NOD/SCID engraftment, the capacity for promoting angiogenesis in an in vivo model was compared. Thus, NOD/SCID mice bearing human melanoma xenografts were intravenously injected with equal numbers of CB CD34+ cells, CD31+CD34brightCD45dimAC133+ CHSPCs or CD31+CD34brightCD45dimAC133- CHSPCs and tumor growth was monitored over time in each cohort (FIG. 6a). Surprisingly, mice injected with CD31+CD34brightCD45dimAC133+ CHSPCs demonstrated a 23.12±0.15% (mean±sem n=8, range 18.35-29.00) fold increase in tumor growth as compared to tumor bearing animals treated with CD31+CD34brightCD45dimAC133- CHSPCs (7.20±0.15% mean±sem n=8, range 5.31-9.87), the parental population of CD34+ cells (5.98±0.23% mean±sem n=8, range 4.99-7.59) and PBS control (9.17±0.14% mean±sem n=8, range 5.30-11.96; AC133+ CHSPCs vs. PBS, p=0.001 by two-tailed, unpaired Students t ...
1. Bauernhofer T, Kuss I, Henderson B, Baum AS, Whiteside TL. Preferential apoptosis of CD56dim natural killer cell subset in patients with cancer. European journal of immunology. 2003;33:119-24 2. Dasgupta S, Bhattacharya-Chatterjee M, OMalley BW, Chatterjee SK. Inhibition of NK Cell Activity through TGF-β1 by Down-Regulation of NKG2D in a Murine Model of Head and Neck Cancer. The Journal of Immunology. 2005;175:5541-50 3. Ferris RL, Whiteside TL, Ferrone S. Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer. Clinical cancer research: an official journal of the American Association for Cancer Research. 2006;12:3890-5 4. Almand B, Resser JR, Lindman B, Nadaf S, Clark JI, Kwon ED. et al. Clinical significance of defective dendritic cell differentiation in cancer. Clinical cancer research: an official journal of the American Association for Cancer Research. 2000;6:1755-66 5. Kuss I, Hathaway B, Ferris RL, Gooding W, Whiteside TL. Decreased ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Human natural killer (NK) cells are innate lymphoid cells with capacity to kill tumor cells and virus-infected cells. According to the expression of CD56 and CD16 several NK cell subsets have been ide
Now I am officially a recurrent miscarriage patient I have been researching reasons (all tests so far have come back normal). Has anybody looked into Natural Killer cells and suppressing the immune
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This is a list of characters that have appeared in Scott Adams Dilbert comic strip. The main character in the strip, Dilbert is a stereotypical technically-minded single male. Prior to October 2014, he was usually wearing a white dress shirt, black trousers and a red-and-black striped tie that inexplicably curves upward; since then, he has worn a red polo shirt with a name badge on a lanyard around his neck. Dilbert received his masters degree in electrical engineering from MIT; he understands engineering well and has good ideas, but has a poor social life. Neither attractive nor blessed with tremendous social graces, Dilbert is capable, but ignored at work and struggles with his romantic life. While he is frequently seen having dates with eligible women, his dates almost invariably end in disaster, usually in surreal and bizarre ways. Dilbert loves computers and technology and will spend much of his free time playing with such things. He had a girlfriend named Liz for a little over two years, ...
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Background: Human peripheral blood NK cells constitutively express CD56 and CD16 antigens. Peripheral blood NK cells seem to be strongly related with decidual NK cells, and may reflect the decidual NK cell functional status. There are varied reports concerning the relationship between NK cell cytotoxicity in women with recurrent spontaneous abortion. Objective: To study NK activity in women with history of RSA by using a non-radioactive cytotoxicity assay. Methods: Peripheral blood lymphocytes from RSA and healthy multiparous women were obtained. Lymphocytes were isolated and mixed with K562 NK-sensitive cell line. A non-radioactive method for NK cell cytotoxicity assessment was utilized. Dead K562 cell populations were detected by FACS Calibur flow cytometry, and the data obtained was analysed on cell-Quest software. The proportion of CD16+ /CD56+ cells was then calculated. Results: The proportion of NK cells were 9.21% ± 3.06 and 13.48% ± 4.09 in healthy women and RSA, respectively. The percentage
Now, results from a new study carried out using a mouse model, show that modified cells called "super natural killer cells" are able to seek out cancer cells in lymph nodes to destroy them, thus halting the process of metastasis. Michael King, senior author of the study, said in a press release: "We want to see lymph node metastasis become a thing of the past.". The super natural killer cells find the cancerous cells in the lymph nodes and induce apoptosis - in other words, the cancer cells self-destruct and disintegrate, thus averting their further lymphatic spread. But what are these super natural killer cells? They are a modified version of the so-called natural killer cells - or NK cells for short.. NK cells are a type of lymphocytes that play a major role in the killing of cancer cells and virus-infected cells by inducing apoptosis. To obtain the "super" version of these lymphocytes, scientists attached nanoparticles to the NK cell surface. These nanoparticles contain a protein dubbed TRAIL ...
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Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. is an eagle-i resource of type Journal article at Oregon Health & Science University.
Natural killer (NK) cell consitutes white blood cells which specifically functions in lysing tumor and virus invected cells. In this research, a commercial
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Inhibition of bone marrow colony formation by human natural killer cells and by natural killer cell-derived colony-inhibiting activity ...
Several experimental models have demonstrated a role for NK cells in host responses against virus infections (Lodoen and Lanier, 2006; Lee et al., 2007). The perhaps most well characterized experimental model system in this respect is that of infection of mice with mouse CMV (Dokun et al., 2001; Lodoen and Lanier, 2006; Sun et al., 2009). In experimental mouse CMV infection, the NK cell response is characterized by proliferation of a specific subset of NK cells that peaks within a few days after infection. Subsequently, this NK cell population undergoes rapid contraction by apoptosis (Dokun et al., 2001; Robbins et al., 2004). To investigate more directly how results from studies of viral infections in experimental model systems compare with infections in humans, we have studied the NK cell response throughout the course of an acute virus infection in humans.. In humans, involvement of NK cells in host responses to viruses were first indicated by the finding that virus-induced IFN-α enhanced NK ...
Sohlberg E, Saghafian-Hedengren S, Bachmayer N, Hamad RR, Bremme K, Holmlund U. Pre-eclampsia affects cord blood NK cell expression of activation receptors and serum cytokine levels but not CB monocyte characteristics. Am J Reprod Immunol 2014; 71: 178-188 ...
Lymph node (LN) plays a critical role in tumor cell survival outside of the primary tumor sites and dictates overall clinical response in many tumor types (1, 2). Previously, we and others have demonstrated that CCL3 plays an essential role in orchestrating T cell-antigen-presenting cell (APC) encounters in the draining LN following vaccination, and such interactions enhance the magnitude of the memory T cell pool (3-5). In the current study, we investigate the cellular responses in the tumor-draining lymph nodes (TDLNs) of a CCL3-secreting CT26 colon tumor (L3TU) as compared to wild-type tumor (WTTU) during the priming phase of an antitumor response (≤10 days). In comparison to WTTU, inoculation of L3TU resulted in suppressed tumor growth, a phenomenon that is accompanied by altered in vivo inflammatory responses on several fronts. Autologous tumor-derived CCL3 (aCCL3) secretion by L3TU bolstered the recruitment of T- and B-lymphocytes, tissue-migratory CD103+ dendritic cells (DCs), and CD49b+
Natural killer (NK) cell cytotoxicity is highly dependent on the ability of NK cells to migrate through the extracellular matrix (ECM) microenvironment. Traditional imaging studies of NK cell migration and cytotoxicity have utilized 2-D surfaces, which do not properly reproduce the structural and mechanical cues that shape the migratory response of NK cells in vivo. In addition, current in vivo imaging does not allow for the accurate long-term single-cell imaging required to dissect the functional heterogeneity of NK cell populations, and importantly, it does not allow studies of human cells. Therefore, it is desirable to implement in vitro migration and killing assays that better mimic in vivo conditions.. We have combined a microwell assay that allows long-term imaging and tracking of small, well-defined populations of NK cells with an interstitial ECM-like matrix to more closely approximate in vivo conditions. The microwells, which are loaded with a gel mixture containing NK and target cells, ...
In order to grow large populations of NK cells, the team started with samples of blood containing a variety of different immune system cells. They placed this sample into a dish containing a type of human leukemia cell called K562. Campanas team genetically modified the K562 cells so they carried on their surfaces many copies of two different proteins, 4-1BBL and IL-15. The genetically modified K562 cells quickly stimulated the expansion of the NK cell population to more than10,000 times their original number. The technique triggered growth of NK cells specifically, which greatly simplified the ability of the researchers to collect a pure population of these immune cells ...
I had my natural killer cell count and function measured. Can anyone help me interpret these results? WBC Lymphs Lymphocites, Absolute - 1,746...
The Cytokine-induced Killer (CIK) cells exist in human body, by enhancing them in vitro, they will be more powerful to fight against the cancer cells after being infused back to patients body.
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Organic killer (NK) cells are good antitumor effector cells, but the generation of enough NK cell numbers for adoptive immunotherapy remains difficult. which was better than with NK cells turned on with IL-2 alone. Intriguingly, adoptively moved NK cells taken care of their improved creation of TNF- and IFN upon restimulation, although they quickly dropped their capability to degranulate and mediate growth cytotoxicity after the transfer. In bottom line, a process was 51-30-9 IC50 developed by us for NK cell enlargement that outcomes in excellent cell produces. The extended NK cells possess powerful antitumor 51-30-9 IC50 activity and and could end up being used at high amounts for adoptive immunotherapy in the center. in a way that is applicable in the treatment centers are essential absolutely. Many protocols used to time put into action interleukin (IL)-2 including mass media for NK cell account activation and enlargement. Although IL-2-including moderate can activate NK cells before their ...
Kumar, V; Sonnenfeld, G; Luevano, E; and Bennett, M, "Mechanism of suppression of natural killer (nk) cell activity by 89s. Abstr." (1979). Subject Strain Bibliography 1979. 1524 ...
Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells
... during CIK cells planning. on the reflection of a pool of growth cytotoxic genetics in CIK cells. The DEMs between CIKIL-15 and CIKIL-2 may contribute to enhanced tumor cytotoxic capacity of CIKIL-2. Significantly, we found that repressed miR-193a-5p might regulate the expressions of inhibitory receptor KLRD1. The total results of the validation assay possess shown that KLRD1 were upregulated in CIK cells. Our results have got supplied brand-new ideas into systems of CIK cells growth and creation cytotoxic function, and shed light on their basic safety for scientific trial. Amazing technological developments have got been converted into better methods to prevent, identify, diagnose and deal with tumor during the previous five years1. Today, people are making it through much longer after their malignancy offers been diagnosed credited to these impressive improvement. Several therapeutics against malignancy possess ...
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The T- and B-Lymphocyte and Natural Killer Cell Profile includes the following tests:. Percentage CD3+; absolute CD3+; percentage CD3+CD4+; absolute CD3+CD4+; percentage CD3+CD8+; absolute CD3+CD8+; percentage CD3-CD56+ natural killer (NK) cells; absolute CD3-CD56+ natural killer (NK) cells; percentage CD19+; absolute CD19+; CD4:CD8 ratio; CBC. .. HIV-1 infection results in a decrease of CD4 T cells, an increase in CD8 T cells, a decrease in the CD4:CD8 ratio, and a progressive destruction of immune function. Enumeration of CD4 and CD8 T cells in HIV-1 seropositive patients may be used for prognostic purposes and to monitor disease progression and retroviral therapy. Natural killer (NK) cells are large granular lymphocytes that mediate MHC-unrestricted cytotoxicity against virus-infected and malignant cells and manufacture a number of cytokines following stimulation of the immune system.. ...
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells and control the cytolytic function. NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in hematological malignancies but not very promising in solid tumors. Increasing evidence suggests that tumor microenvironment regulate the phenotype and function of NK cells. In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on effector and cytolytic function of NK cells. We also summarized various NK cell-based immunotherapeutic strategies used in the past, and the possibilities to improve the function of NK cell
CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS Williams Hematology CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS GIORGIO TRINCHIERI LEWIS L. LANIER Identification and Definition of Natural Killer Cells Definition Morphology Origin and Tissue Distribution Mechanisms of Natural Killer Cell Functions Cell-Mediated Cytotoxicity Production of Cytokines Physiologic Roles of Natural Killer Cells Natural Resistance Regulation of…
Alterations in natural killer (NK) cell number and function were examined in cigarette smokers and nonsmokers with silicosis, silica dust exposure without silicosis, or no exposure to rock dust. Blood NK cell number, percentage, and tumoricidal activity were measured in 120 hardrock miners, 57 of whom had radiographic evidence of silicosis, and in 33 community referents. There was a significant in
Human plasmacytoid dendritic cells secrete high levels of IFNa and are thus implicated in the activation of NK cells. Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cytotoxicity. We show that pDC mediate these processes by different mechanisms, some of which overlap. Human NK cells were analysed after co-culture with immature or CpG-matured blood pDC or with supernatant from these cells. Maximal CD69 expression by NK cells was mediated by supernatant from mature pDC and did not require pDC contact. Up-regulation was due in part to IFNa but also to factors in IFNa negative supernatant from immature DC. HLA-DR expression was independent of secreted molecules but required contact with immature or mature DC. Enhanced NK cytotoxicity, measured by killing of K562 targets and expression of CD107a, was mediated by multiple factors including type I IFN, supernatant from immature pDC cultures and contact with immature or mature pDC
Natural killer (NK) cells provide essential protection against viral infections. greater potency with greater education and (2) education on self allows the NK cell to detect aberrations in MHC I expression a common occurrence during many viral infections. Many studies have indicated an important role for iNKR and MHC I in disease making these receptors attractive targets for manipulating NK-cell reactivity in the medical center. A greater understanding of iNKR and their ability to regulate NK cells will provide a basis for future attempts at translating their potential power into benefits for human health. sensitivity to stimulatory receptor cross-linking compared to "unlicensed" NK cells lacking self-specific iNKR. Two proposed models attempt to account for the differential responsiveness of NK cells stemming from your presence or absence of self-MHC binding iNKR. The "disarming" model contends that NK cells without any iNKR for self-MHC I are rendered hyporesponsive due to chronic low-level ...
Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system. The role NK cells play is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response. NK cells provide rapid responses to viral-infected cells, acting at around 3 days aft
Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous quantity of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research, and led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research now faces the challenge of integrating isolated biochemical pathways into complex gene and protein regulatory circuits. This volume collects topics on natural killer cells, mast cells, phagocytes, toll-like ...
Recently, a number of groups have identified liver-resident NK cells (which are sometimes considered to be helper ILC1) in mice. The first major paper to come out of my research group examined peripheral blood and intrahepatic NK cells from recipients of HLA-mismatched liver transplants to show that an equivalent, liver-resident NK cell is also present in humans (Cuff et al, 2016, J Immunol). We further showed that the precursors of liver-resident NK cells can be recruited from the blood during adult life and defined conditions that can convert circulating NK cells to cells with a liver-resident phenotype. Our goal now is to define the function of these cells, both in humans and in mice ...
Not that lucky 8 years with no diagnosis Was harder to deal with as there was nothing to treat.... nothing I still thing egg issues maybe at play, as it was strange to go on meds to improve eggs and fall naturally.... But ill never - page 52
Nukleosóm je pri evkariotih enota v organizaciji kromatina, ki obsega približno 146 baznih parov DNK, ki je 1,67-krat tesno ovita okrog histonskega oktamera, torej osmih histonskih molekul (po dve kopiji histonov H2A, H2B, H3, H4).[1]. Nukleosome povezuje povezovalna DNK dolžine do 80 baznih parov vezana na zunanji histon H1. Nukleosomi omogočajo strnjenost celotne dednine v jedru, ki meri približno 10 μm. Več nukleosomov se povezuje v kromosom. Nukleosomi so nosilci epigenetskih informacij v obliki kovalentnih modifikacij pripadajočih jedrnih histonov. Niso statične, temveč dinamične strukture. Vezavo transkripcijskih faktorjev na posamezna mesta na DNK lahko facilitirajo ali zavirajo.. ...
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NK cells respond to tumor and virus-infected cells directly through several activation receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc receptor CD16 for antibody-coated cells. Triggering of NK-cell effector functions through these receptors depends on physically associated transmembrane signaling adaptors, such as FcRγ (also known as FcεRIγ) and CD3ζ, both of which have been traditionally believed to be expressed by all mature NK cells. However, we have identified a distinct subset of human NK cells that are deficient for FcRγ expression but express normal levels of CD3ζ. FcRγ-deficient NK cells were readily detectable in about one-third of the healthy individuals examined. The deficiency was confined to the CD56dim population and was due to low FcRγ mRNA. FcRγ-deficient NK cells displayed dramatically reduced expression of the natural cytotoxicity receptors NKp46 and NKp30 but still expressed substantial levels of CD16. Compared to ...
A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via ligation of the NK inhibitory receptor CD94/NK group 2 member A (NKG2A). Gene expression data from approximately 10,000 tumor samples showed widespread HLAE expression, with levels correlating with those of KLRC1 (NKG2A) and KLRD1 (CD94). To bypass HLA-E inhibition, we developed a way to generate highly functional NK cells lacking NKG2A. Constructs containing a single-chain variable fragment derived from an anti-NKG2A antibody were linked to endoplasmic reticulum-retention domains. After retroviral transduction in human peripheral blood NK cells, these NKG2A protein expression blockers (PEBLs) abrogated NKG2A expression. The resulting NKG2Anull NK cells had higher cytotoxicity against HLA-E-expressing tumor cells. Transduction of anti-NKG2A PEBL produced more potent cytotoxicity than interference with an anti-NKG2A ...
Definition of natural killer cell stimulating factor in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is natural killer cell stimulating factor? Meaning of natural killer cell stimulating factor as a legal term. What does natural killer cell stimulating factor mean in law?
Definition of Natural killer cells in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Natural killer cells? Meaning of Natural killer cells as a legal term. What does Natural killer cells mean in law?
This sensitivity allows natural killer cells to vigorously initiate natural killer cytotoxicity (by emptying granules of porforin and granzyme) and inflammation as soon as pathogenesis is detected, and is essential to protection against viruses and tumors. Natural killer cells have genomic (not needed recombination, or RAG-independent) cell surface receptors which recognize classical Class I MHC molecules (and structural relatives like MICA, RAE-1 and H-60).. Natural killer cells lack TcRs, CD4s and CD8; instead, they have: cell-surface activating receptors, which bind noncovalently to molecules with ITAMs; and on the cytoplasmic side, inhibitory receptors with ITIM(s) which -- upon phosphorylation -- recruit and activate SHP-1 & -2, which inhibit the activating receptors. The balance between activating signals and inhibitory signals is what determines whether a natural killer cell will destroy or bypass a microbe it encounters. ...
Monocytes and natural killer (NK) cells from cord blood (CB) of children with pre-eclamptic or healthy mothers were analyzed by flow cytometry for surface markers and intracellular cytokines. In addition, serum cytokine profiles were investigated using ELISA or cytometric bead array. ...
Yakults website for healthcare professionals, scientists and researchers. Information on probiotics, the science behind them, areas of potential health benefit and Yakult product information. There is also a resource centre which includes current and past issues of our quarterly newsletter, publications, key references and conference dates. Information on this website has been put together by Yakults science team which consists of a microbiologist, dietitians and nutritionists.
1P6F: Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors.
unique single-chain, tri-specific NK cell engager (TriKE) and tetra-specific NK cell engager (TetraKE) platforms targeting hematologic malignancies, sarcomas and carcinomas (solid tumors). The presentation will address both the TriKE and TetraKE constructs, as well as our second-generation anti-CD16-IL-15-anti-CD33 TriKE (OXS-C3550); another first-of-its-kind, single-chain, tri-specific NK cell engager (TriKE).. NK cell cancer-killing activity is expected to be increased by bringing the NK cells in close proximity to the cancer cells. This may be achieved by engagers that bind to CD16 on the surface of NK cells and bind specific proteins (such as CD33) on the surface of cancer cells, thus forming an immune synapse between the NK cell and the cancer cell. Our lead TriKE, anti-CD16-IL-15-anti-CD33 (OXS-3550) is expected to be in the clinic in the second half of 2018. The TriKE constructs utilize the inclusion of interleukin-15 (IL-15), a peptide that leads to proliferation and activation of the ...
Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
NK cells are the gatekeepers of the innate immune system. CiMaas utilizes an optimized NK cell expansion technology to treat cancer.
silent killer - MedHelps silent killer Center for Information, Symptoms, Resources, Treatments and Tools for silent killer. Find silent killer information, treatments for silent killer and silent killer symptoms.
AFM13-mediated activation of NK cells. One arm of AFM13 binds to the CD30 antigen on lymphoma cells, whereas the other arm binds to the CD16A antigen on the NK
Recognition of foreign DNA in the cytosol of host cells is critical for the initiation of immune responses to DNA viruses. Recognition of viral DNA activates nu...
Prvobitna analiza DNK kromosoma Y, koja se, kao i mitohondrijska DNK, nasljeđuje od samo jednog roditelja, bila je dosljedna modelu nedavnog afričkog pretka. Međutim, mitohondrijski i podaci sa Y kromosoma nisu se mogli objasniti istom ekspanzijom modernog čovjeka iz Afrike; ekspanzija Y kromosoma uključivala bi genetsko miješanje koje bi zadržalo regionalno lokalne mitohondrijske linije. Uz to, podaci s Y kromosoma ukazali su na kasnije širenje natrag u Afriku iz Azije, pokazavši da genski tok među regijama nije bio jednosmjeran.[81] Rana analiza 15 nekodirajućih dijelova kromosoma X otkrila je dodatne nepodudarnosti s hipotezom nedavnog afričkog pretka. Ta analiza pronašla je višemodalnu distribuciju vremena koalescencije do najmlađeg zajedničkog pretka za te segmente DNK, u suprotnosti s očekivanjima za nedavnu afričku zamjenu; bilo je više vremena koalescencije prije gotovo 2 milijuna godina nego što se očekivalo, što ukazuje na to da se jedna drevna populacija odvojila ...
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Cytokine-induced killer (CIK) cells exhibit high proliferation rate and cytotoxic activity in vitro. The major effector cells are the CD3+CD56+ subset. The cytolytic activity of CIK cells being independent of MHC restriction implies feasibility in using CIK cells allogeneic to the tumors. Experiments to block the MHC class-I and -II pathways on tumors-RNA transfected DCs showed that only MHC class-I blocking led to a significant reduction of heterogeneous CIK cells cytotoxicity after the co-culture. The safety of CIK cells was demonstrated by the lack of cytotoxicity toward autologous as well as allogeneic normal cells. Co-culture of CIK cells with dendritic cells (DCs) has been reported by us and others in a myriad of cancer (e.g., cholangiocarcinoma, osteosarcoma, glioblastoma multiforme, multiple myeloma, hepatocellular carcinoma, pancreatic carcinoma, renal & colon carcinoma, murine leukemia & lymphoma showing enhancement of anti-tumor cytotoxicity of CIK cell in all. The co-culture of CIK ...
Malignant gliomas are very aggressive and among the most common of brain tumors. A diagnosis carries with it a median survival of approximately 12 months, with 90 - 95% of patients surviving less than 2 years. The current standard treatment of surgical resection followed by radiation therapy and chemotherapy has not substantially prolonged survival.. Dendritic cells (DCs) are immune cells that form part of the mammalian immune system. Their main function is to process antigen material and present it on the surface to other cells of the immune system, thus functioning as antigen-presenting cells.In the present study, DCs were used for antigen presentation of glioma antigens to directly induce a cytotoxic T-cell response. Cytokine-induced killer (CIK)cells are shown to be a heterogeneous population, and the major population expresses both the T cell marker CD3 and the NK cell marker CD56, and is termed NKT cells, which has shown significant anti-tumor activity in both clinical trials and animal ...
Natural Killer (NK) cells were initially named based on their propensity for cytolytic function in the absence of any specific kind of activation. NK cells are an important part of innate immunity, defending the body against both virally infected cells and tumor cells. Natural Killer T (NKT) cells represent a special hybrid of T cell and NK cells. They express a T cell receptor complex and several NK cell markers. Unlike T cells, they mainly recognize lipid antigen presented by CD1d and not MHCs. NKT cells are capable of producing both Th1 and Th2-related cytokines. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
CD4+/CD8+/CD3+ cells are 1-4% range of the lymphocyte population from our HIV+ patients. Most of the cells are brightCD4+/dimCD8+ but all combinations of bright and dim are possible. We include these dual positive cells in both the CD3+/CD4+ and CD3+/CD8+ counts. What do other labs do with these cells and why? -----Original Message----- From: Kenneth Ault [mailto:aultk at mmc.org] Sent: Wednesday, October 31, 2001 7:32 PM To: cyto-inbox Subject: Re: cd4 cd8 coexpression A phenomenon frequently forgotten is coincidence. If two cells enter the observation volume at the same time they will be seen as one event with the properties of both cells. This is a very common problem in my world (platelets) and should be considered as a possible explanation for any kind of unexpected dual expression of markers. It would be interesting to know if the frequency of CD4/CD8 doubles changes as the particle flow rate changes (i.e change the sample pressure or dilute the specimen.) Ken Ault ...
In the present study, combining subjects with different levels of corpulence (from moderate to severe obesity) and 2 clinical intervention studies inducing weight loss, we showed strong links between fat mass and the frequencies of CD14dimCD16+ monocytes in the population. Indeed, we observed an increase of about twice the percentage of CD16+ monocyte subsets in obesity and a reduction of these cell populations by drastic fat mass loss. A fat mass decrease of at least 5% was sufficient to observe a reduction in the CD14dimCD16+ subpopulation. On the contrary, we could not demonstrate a convincing link with glucose homeostasis in patients involved in clinical trials improving insulin sensitivity. In this context, the only association found with metabolic parameters was with fasting TG.. In healthy humans, 3 monocyte subpopulations have been described (CD14+CD16−, CD14+CD16+, and CD14dimCD16+), differing in phenotype and function.19 Human obesity is characterized by a significant increase in the ...

In Vitro and in Vivo Activity of the Maytansinoid Immunoconjugate huN901-N2′-Deacetyl-N2′-(3-Mercapto-1-Oxopropyl)-Maytansine...In Vitro and in Vivo Activity of the Maytansinoid Immunoconjugate huN901-N2′-Deacetyl-N2′-(3-Mercapto-1-Oxopropyl)-Maytansine...

CD56 antigen, identified as neuronal cell adhesion molecule (NCAM; Ref. 23 ), is a membrane glycoprotein belonging to the ... CD56-specific cytotoxicity of huN901-DM1 in mixed cultures of CD56+ and CD56− cells. CD56+ OPM2 cells were mixed with CD56− ... CD56+ OPM2 (CD138+/CD20−) MM cells were cultured with CD56− SUDHL4 cells (CD138−/CD20+) at a ratio of 1:2 or with CD56− WSU-WM ... HuN901-DM1 Selectively Depletes CD56+ MM Cells in Mixed Cultures with CD56− Cells.. Because huN901-DM1 did not affect CD56− ...
more infohttp://cancerres.aacrjournals.org/content/64/13/4629.long

Final Diagnosis -- Case 406Final Diagnosis -- Case 406

Mechtersheimer G, Staudter M, and Moller P. Expression of the natural killer cell-associated antigens CD56 and CD57 in human ... The tumor cells of the present case are also positive for other "neural" markers, CD99 and CD56 (Figure 6), supporting the ... Mechtersheimer and coworkers demonstrated that CD56 was detectable in 3 of 3 benign and 8 of 13 malignant schwannomas (6). In ...
more infohttp://path.upmc.edu/cases/case406/dx.html

ORBi: Browsing ORBiORBi: Browsing ORBi

Immunohistochemistry showed positivity for the S-100 protein, the CD56 and for the epithelial membrane antigen (EMA) and a ...
more infohttp://orbi.ulg.ac.be/browse?type=author&value=Belachew%2C+Shibeshih+p001632

Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New...Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New...

... and some positive for CD56 (Figure 5C). Rosette formations areas expressed CD56 (Figure 5D), Syn (Figure 5E) and CD99. Actin ... The antigens are summarized in Table 1.. Immunohistochemical staining showed that the spindle and grandular tumor components ... Some neural markers, such as S-100, CD56 and protein gene product 9.5 (PGP 9.5) are considered sensitive markers for peripheral ... Cytokeratin was expressed in the glandular region, CD56 expressed in most spindle-shaped cells and rosette formations, and Syn ...
more infohttp://jcancer.org/v03p0303.htm

Abstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma | Cancer ResearchAbstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma | Cancer Research

Abstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma. Reuben Benjamin, Maud Condomines ... CD56 CAR cells were generated by retroviral transduction of human T cells and showed antigen dependent proliferation and ... These results demonstrate for the first time the impressive anti-tumor efficacy of a CD56 targeted chimeric antigen receptor in ... Abstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma ...
more infohttp://cancerres.aacrjournals.org/content/72/8_Supplement/3499

Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem...Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem...

Likewise, the tumor antigen CDCP1 (CD318) was not expressed on primary CD271bright CD56− and CD271brightCD56+ cells (Figure 2B ... B) CD56 epitopes NCAM16.2 and 39D5 are expressed on a rare CD271+ bone marrow subset. (C) CD271+CD56+ and CD271+CD56− bone ... The CD271brightCD56+ population is enriched for CFU-F. To determine the clonogenic potential of sorted CD56+ and CD56− subsets ... CD271, SSEA-4 and CD56 were more densely expressed on CD271brightCD56+ derived MSC, whereas MSCA-1 (W8B2 antigen) expression ...
more infohttp://www.haematologica.org/content/94/2/173

CD56 Human Recombinant Protein - CD Antigens - Recombinant Protein - Full-Length Protein - Products  | ProMabCD56 Human Recombinant Protein - CD Antigens - Recombinant Protein - Full-Length Protein - Products | ProMab

The CD56 is purified by proprietary technologyary technonlogyary chromatographic techniques. ... CD56 Human Recombinant (aa 20-220) expressed in E.coli, shows a 48 kDa band on SDS-PAGE. ... Neural cell adhesion molecule 1, 140 kDa isoform, N-CAM 140, NCAM-140, CD56 antigen, NCAM1, NCAM, CD56, MSK39. ... CD56 Human Recombinant (aa 20-220) expressed in E.coli, shows a 48 kDa band on SDS-PAGE. The CD56 is purified by proprietary ...
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Massive intravenous immunoglobulin treatment in women with four or more recurrent spontaneous abortions of unexplained etiology...Massive intravenous immunoglobulin treatment in women with four or more recurrent spontaneous abortions of unexplained etiology...

Antigens, CD56. Biological Markers. Down-Regulation / immunology*. Female. Humans. Immunoglobulins, Intravenous / therapeutic ... 0/Antigens, CD56; 0/Biological Markers; 0/Immunoglobulins, Intravenous; 0/Receptors, IgG ...
more infohttp://www.biomedsearch.com/nih/Massive-intravenous-immunoglobulin-treatment-in/11775009.html

The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients.The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients.

0/Antigens, CD; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; EC 3.5.4.4/Adenosine Deaminase; EC 3.6.1.5/ ... Antigens, CD / metabolism*. Apyrase / metabolism*. Case-Control Studies. Female. Gene Expression Regulation, Enzymologic*. ...
more infohttp://www.biomedsearch.com/nih/activity-expression-NTPDase-altered-in/19914228.html

TNO Repository search for: subject:Myelin Basic ProteinsTNO Repository search for: subject:'Myelin Basic Proteins'

Chemicals/CAS: Antigens, CD4; Antigens, CD56; Biological Markers; Epitopes; Histocompatibility Antigens Class II; Myelin Basic ... Antigens, CD4 · Antigens, CD56 · Biological Markers · Cytotoxicity, Immunologic · Epitopes · Histocompatibility Antigens Class ... Biology · Cd8 antigen · HLA antigen class 2 · Major histocompatibility antigen · Nyelin basic protein · Nerve cell adhesion ... as well as killing of CD56-transfected cells indicate that homotypic CD56 interactions are involved in the MHC-unrestricted ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject%3A%22Myelin%20Basic%20Proteins%22

NCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 AntibodyNCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 Antibody

Suggested Antigen Peptide Sequences for NCAM1 Gene. GenScript: Design optimal peptide antigens:. *Neural cell adhesion molecule ... R&D Systems Proteins and Enzymes for NCAM1 (NCAM-1/CD56). *R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody ... R&D Systems ELISAs, Proteome Profiler Antibody Arrays, Luminex Assays, and other biochemical assays for NCAM1 (NCAM-1/CD56) ... Molecular and functional analysis of human natural killer cell- associated neural cell adhesion molecule (N-CAM/CD56). (PMID: ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAM1

malignant neuroendocrine neoplasm diagnosis drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginemalignant neuroendocrine neoplasm diagnosis drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

Antigens, CD56 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chromogranin A / metabolism. ... Chemical-registry-number] 0 / Antigens, CD56; 0 / Chromogranin A; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Nuclear ... Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins ... Melanoma-Specific Antigens. Neoadjuvant Therapy. Tumor Cells, Cultured. *MedlinePlus Health Information. consumer health - ...
more infohttp://www.bmlsearch.com/?kwr=malignant+neuroendocrine+neoplasm+diagnosis+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

figo stage i vaginal carcinoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginefigo stage i vaginal carcinoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

Antigens, CD56 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chromogranin A / metabolism. ... Chemical-registry-number] 0 / Antigens, CD56; 0 / Chromogranin A; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Nuclear ...
more infohttp://www.bmlsearch.com/?kwr=figo+stage+i+vaginal+carcinoma+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Anti-CD56 (NKI-nbl-1) h(CD28-CD3ζ) CAR, pCDCAR1 vector - Creative BiolabsAnti-CD56 (NKI-nbl-1) h(CD28-CD3ζ) CAR, pCDCAR1 vector - Creative Biolabs

Creative Biolabs provides Anti-CD56 (NKI-nbl-1) h(CD28-CD3ζ) CAR, pCDCAR1 product for Biopharmaceutical research,preclinical ... pCDCAR1 CD56 h(28ζ) (CAR-ZP5791). The vector of anti-CD56 chimeric antigen receptor (CAR) is constructed for the engineering of ... CD56 Antigen; N-CAM-1; NCAM-1; MSK39; CD56 ... It transmits an activation signal to the T cell after antigen ... CellRapeutics™ Chimeric Antigen Receptor (CAR) Technology. *T-Scan Platform for High-throughput Identification of T Cell- ...
more infohttps://www.creative-biolabs.com/car-t/pcdcar1-cd56-h-28-73731.htm

CD56+CD3− lymphocytes express CD40L after incubation  | Open-iCD56+CD3− lymphocytes express CD40L after incubation | Open-i

CD56+CD3− lymphocytes express CD40L after incubation with IL-2. Staining profiles of o.n. cultured lymphocytes, obtained as ... Antigens, CD3/analysis. *Antigens, CD56/analysis. *CD40 Ligand. *Histocompatibility Antigens Class I/analysis ... Figure 5: CD56+CD3− lymphocytes express CD40L after incubation with IL-2. Staining profiles of o.n. cultured lymphocytes, ... Figure 5: CD56+CD3− lymphocytes express CD40L after incubation with IL-2. Staining profiles of o.n. cultured lymphocytes, ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2196353_JEM.962210f5&req=4

anti-NCAM antibody | Mouse NCAM / CD56 Monoclonal Antibody (Clone MEM-188)-NP 000606.3anti-NCAM antibody | Mouse NCAM / CD56 Monoclonal Antibody (Clone MEM-188)-NP 000606.3

CD56 Monoclonal Antibody (Clone MEM-188)-NP_000606.3 (MBS245133) product datasheet at MyBioSource, Primary Antibodies. ... Anti-NCAM / CD56 Antibody (clone MEM-188) IHC-plus; NCAM1; CD56; CD56 antigen; MSK39; NCAM-1; N-CAM-1; NCAM; Human NCAM; CD56 ... Anti-CD56 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat- ... neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11 ...
more infohttps://www.mybiosource.com/monoclonal-bovine-human-ovine-pig-antibody/ncam-cd56/245133

Code System ConceptCode System Concept

CD56 - Cluster of differentiation antigen 56 Current Synonym true false 1229941018 Cluster of differentiation antigen 56 ... CD56 - cluster of differentiation antigen 56 Current Synonym true false 3744501017 N-CAM - neural cell adhesion molecule ... Lymphocyte antigen CD56 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD56 (substance). ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=42891003

Natural Killer Cell Surface Antigen | Blood Test - Life ExtensionNatural Killer Cell Surface Antigen | Blood Test - Life Extension

NK cells are classified as being positive for CD56 and negative for CD3. In other words, they express NK cell markers with a 95 ... Cells in our immune system are characterized by unique markers (antigens) on their surface membranes called CD proteins. CD ...
more infohttps://www.lifeextension.com/lab-testing/itemLC505016/Natural-Killer-Cell-Surface-Antigen-CD3-CD56-Marker-Analysis-Blood-Test

Frontiers | Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease |...Frontiers | Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease |...

IELs were defined based on co-expression of CD56 and CD127 antigens (29). It was shown that plasticity and diversity of these ... NK cells were further subdivided by expression of CD16 and CD56 antigens (Figure S3 in Supplementary Material). In agreement ... From the seven markers used to define rhesus peripheral NK cells, the NKG2D antigen was particularly critical, as it not only ... Louis, MO, USA) (13). Cells were then stained with antibodies against surface antigens (Table 1), fixed in 1× BD Stabilizing ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01603/full

Plasma cell leukemia - WikipediaPlasma cell leukemia - Wikipedia

17%); pPCL plasma cells often lack CD56 antigen which is present on the majority of plasma cells taken form multiple myeloma ... For example: pPCL plasma cells more often express CD20 antigen, which is considered important in anchoring plasma cells to the ... Examination of plasma cell immunophenotype by measuring certain of their cell surface antigens, particularly Cluster of ...
more infohttps://en.wikipedia.org/wiki/Plasma_cell_leukemia

Genetic Modification of Human B-Cell Development: B-Cell Development Is Inhibited by the Dominant Negative Helix Loop Helix...Genetic Modification of Human B-Cell Development: B-Cell Development Is Inhibited by the Dominant Negative Helix Loop Helix...

Ten days later, cell suspensions were analyzed by flow cytometry for cell surface expression of CD19 and CD56 antigens. The ... The absolute numbers of CD56+ Id3+ cells were 25% higher than the numbers of CD56+ cells found in the control cultures (Table 1 ... Absolute Numbers of CD56+ NK Cells Upon Sequential Culture of Transduced CD34+CD38− FL Cells Upon S17 and Cytokines ... Most importantly, we observed that CD56+ NK cells could be detected in the progeny of both the Id3− and the Id3+ fractions (Fig ...
more infohttp://www.bloodjournal.org/content/94/8/2637?ijkey=f708ddd0b872676df74391183bb2c1a201b3645b&keytype2=tf_ipsecsha&sso-checked=true

EasySep™ HLA Chimerism Buffy Coat CD56 Positive Selection KitEasySep™ HLA Chimerism Buffy Coat CD56 Positive Selection Kit

HLA Chimerism Buffy Coat CD56 Positive Selection Kit II is designed to isolate CD56+ cells with an EasySep™ magnet from freshly ... The CD56 antigen is expressed on NK cells and NKT cells.. This product replaces the EasySep™ Human Buffy Coat CD56 Positive ... EasySep™ HLA Chimerism Buffy Coat CD56 Positive Selection Kit (Catalog #17875). *EasySep™ HLA Chimerism Buffy Coat CD56 ... The EasySep™ HLA Chimerism Buffy Coat CD56 Positive Selection Kit II is designed to isolate CD56+ cells from freshly prepared ...
more infohttps://www.stemcell.com/products/product-types/cell-isolation-products/easysep-hla-chimerism-buffy-coat-cd56-positive-selection-kit.html

Produktübersicht anti-CD56 AntikörperProduktübersicht anti-CD56 Antikörper

Ausgesuchte Qualitäts-Hersteller für CD56 Antikörper. Hier bestellen. ... Monoklonale und polyklonale CD56 Antikörper für viele Methoden. ... CD56 (NCAM1) Antigen-Profil Protein Überblick This gene encodes a cell adhesion protein which is a member of the immunoglobulin ... CD56 140 kDa isoform , adhesion molecule , CD56 antigen , neural cell adhesion molecule 1-like , N-CAM-1-A , NCAM-1-A , neural ...
more infohttps://www.antikoerper-online.de/abstract/Neural+Cell+Adhesion+Molecule+1+

Medium for culturing autologous human progenitor stem cells and applications thereof - Instituto Cientifico Y Technologico De...Medium for culturing autologous human progenitor stem cells and applications thereof - Instituto Cientifico Y Technologico De...

... antibodies human anti-CD56 (CD56 is an extracellular antigen characteristic of skeletal muscle) in absence of the specific ... which could be identified by the presence of the antigen CD56, the intracytoplasmic expression of desmine and the absence of ... A method according to claim 51, wherein the human anti-CD56 antibodies are joined to magnetic microspheres. 53. A procedure for ... A method according to claim 49, wherein the human anti-CD56 antibodies are joined to magnetic microspheres. 51. A method ...
more infohttp://www.freepatentsonline.com/y2006/0110368.html

Anti-CD56 (HuN901) h(41BB-CD3ζ) CAR, pCDCAR1 vector - Creative BiolabsAnti-CD56 (HuN901) h(41BB-CD3ζ) CAR, pCDCAR1 vector - Creative Biolabs

Creative Biolabs provides Anti-CD56 (HuN901) h(41BB-CD3ζ) CAR, pCDCAR1 product for Biopharmaceutical research,preclinical and ... pCDCAR1 CD56 h(BBζ) (CAR-ZP5884). The vector of anti-CD56 chimeric antigen receptor (CAR) is constructed for the engineering of ... CD56 Antigen; N-CAM-1; NCAM-1; MSK39; CD56 ... It transmits an activation signal to the T cell after antigen ... this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to ...
more infohttps://www.creative-biolabs.com/car-t/pcdcar1-cd56-h-bb-73822.htm
  • The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD56 antibody linked to CD28 and CD3ζ signaling domains. (creative-biolabs.com)
  • Staining profiles of o.n. cultured lymphocytes, obtained as indicated in the Materials and Methods section, by using PE-labeled antiCD40L TRAP-1, FITC-labeled anti-CD3, or anti-CD56 mAbs in a classical double fluorescence assay. (nih.gov)
  • We also assessed the expression of CD40L on polyclonal NK effectors derived from peripheral blood of normal donors, by double staining with anti-CD40L mAb TRAP-1 and anti-CD3 or anti-CD56 mAb. (nih.gov)
  • Anti-CD56 antibody IHC of human brain, cortex. (mybiosource.com)
  • A number of experimental results including separation of CD4+CD56+ T cells into CD56 high and low expressing populations, cold target inhibition, as well as killing of CD56-transfected cells indicate that homotypic CD56 interactions are involved in the MHC-unrestricted lysis. (tudelft.nl)
  • Examination of plasma cell immunophenotype by measuring certain of their cell surface antigens, particularly Cluster of differentiation. (wikipedia.org)
  • CD56 is also expressed at lower levels on normal tissue types including neuronal cells, NK cells and a subset of activated T cells. (aacrjournals.org)
  • Phenotype analysis revealed that the expression of CD10, CD26, CD106, and CD146 was restricted to the MSCA-1 + CD56 − mesenchymal stem cells subset and CD166 to MSCA-1 + CD56 ± mesenchymal stem cells. (haematologica.org)
  • Our data suggest that the MSCA-1 + CD56 + subset is an attractive starting population for autologous chondrocyte transplantation. (haematologica.org)
  • This product replaces the EasySep™ Human Buffy Coat CD56 Positive Selection Kit (Catalog #18085) and EasySep™ HLA Buffy Coat CD56 Positive Selection Kit (Catalog #18085HLA), for even faster cell isolations. (stemcell.com)
  • CD56 CAR cells were generated by retroviral transduction of human T cells and showed antigen dependent proliferation and cytokine secretion in vitro when stimulated with CD56 positive myeloma cells. (aacrjournals.org)
  • CD56 is a member of the neural cell adhesion molecule family expressed on cells of the central nervous system and also on NK cells. (tudelft.nl)
  • Our findings raise the possibility that CD4+CD56+ T cells sharing properties of both typical Ag-specific Th0-like T cells and NK cells might be involved in damage of tissues expressing CD56/neural cell adhesion molecule, such as the central nervous system. (tudelft.nl)
  • The tumor cells of the present case are also positive for other "neural" markers, CD99 and CD56 (Figure 6), supporting the diagnosis. (upmc.edu)
  • Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. (mybiosource.com)
  • The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. (creative-biolabs.com)
  • CD56+CD3− lymphocytes express CD40L after incubation with IL-2. (nih.gov)
  • CD56 interactions are not sufficient but are required for effector/target interaction. (tudelft.nl)
  • CD56 CAR therapy therefore represents an attractive immunotherapy option and its use in patients with relapsed refractory myeloma should be considered. (aacrjournals.org)