Receptors, Cytoadhesin: A group of INTEGRINS that includes the platelet outer membrane glycoprotein GPIIb-IIIa (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX) and the vitronectin receptor (RECEPTORS, VITRONECTIN). They play a major role in cell adhesion and serve as receptors for fibronectin, von Willebrand factor, and vitronectin.Antigens, CD36: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Thrombospondins: A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Thrombospondin 1: An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.Activin Receptors, Type I: One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB).Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Receptors, Transforming Growth Factor beta: Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Antigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Antimicrobial Cationic Peptides: Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.Antigens, CD40: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Plasmodium falciparum: A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.Fatty Acid Transport Proteins: A broad category of membrane transport proteins that specifically transport FREE FATTY ACIDS across cellular membranes. They play an important role in LIPID METABOLISM in CELLS that utilize free fatty acids as an energy source.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Homozygote: An individual in which both alleles at a given locus are identical.Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.TriglyceridesMalaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Mali: A country in western Africa, east of MAURITANIA and south of ALGERIA. Its capital is Bamako. From 1904-1920 it was known as Upper Senegal-Niger; prior to 1958, as French Sudan; 1958-1960 as the Sudanese Republic and 1959-1960 it joined Senegal in the Mali Federation. It became an independent republic in 1960.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Muromonab-CD3: Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti).Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Epitopes: Sites on an antigen that interact with specific antibodies.Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)Azides: Organic or inorganic compounds that contain the -N3 group.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Lysosome-Associated Membrane Glycoproteins: Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Science: The study of natural phenomena by observation, measurement, and experimentation.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Chromogenic Compounds: Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (1/1441)

CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake.  (+info)

Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. (2/1441)

Rat Sertoli cells phagocytose apoptotic spermatogenic cells, which consist mostly of spermatocytes, in primary culture by recognizing phosphatidylserine (PS) exposed on the surface of degenerating spermatogenic cells. We compared the mode of phagocytosis using spermatogenic cells at different stages of spermatogenesis. Spermatogenic cells were separated into several groups based on their ploidy, with purities of 60-90%. When the fractionated spermatogenic cell populations were subjected to a phagocytosis assay, cells with ploidies of 1n, 2n, and 4n were almost equally phagocytosed by Sertoli cells. All the cell populations exposed PS on the cell surface, and phagocytosis of all cell populations was similarly inhibited by the addition of PS-containing liposomes. Class B scavenger receptor type I (SR-BI), a candidate for the PS receptor, was detected in Sertoli cells. Overexpression of the rat SR-BI cDNA increased the PS-mediated phagocytic activity of Sertoli cell-derived cell lines. Moreover, phagocytosis of spermatogenic cells by Sertoli cells was inhibited in the presence of an anti-SR-BI antibody. Finally, the addition of high density lipoprotein, a ligand specific for SR-BI, decreased both phagocytosis of spermatogenic cells and incorporation of PS-containing liposomes by Sertoli cells. In conclusion, SR-BI functions at least partly as a PS receptor, enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.  (+info)

Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface. (3/1441)

In addition to its effect on high density lipoprotein (HDL) cholesteryl ester (CE) uptake, scavenger receptor BI (SR-BI) was recently reported to stimulate free cholesterol (FC) flux from Chinese hamster ovary (CHO) cells stably expressing mouse SR-BI, a novel function of SR-BI that may play a role in cholesterol removal from the vessel wall where the receptor can be found. It is possible that SR-BI stimulates flux simply by tethering acceptor HDL particles in close apposition to the cell surface thereby facilitating the movement of cholesterol between the plasma membrane and HDL. To test this, we used transiently transfected cells and compared the closely related class B scavenger receptors mouse SR-BI and rat CD36 for their ability to stimulate cholesterol efflux as both receptors bind HDL with high affinity. The results showed that, although acceptor binding to SR-BI may contribute to efflux to a modest extent, the major stimulation of FC efflux occurs independently of acceptor binding to cell surface receptors. Instead our data indicate that SR-BI mediates alterations to membrane FC domains which provoke enhanced bidirectional FC flux between cells and extracellular acceptors.  (+info)

Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. (4/1441)

Recent studies have indicated that the scavenger receptor class B type I (SR-BI) may play an important role in the uptake of high density lipoprotein (HDL) cholesteryl ester in liver and steroidogenic tissues. To investigate the in vivo effects of liver-specific SR-BI overexpression on lipid metabolism, we created several lines of SR-BI transgenic mice with an SR-BI genomic construct where the SR-BI promoter region had been replaced by the apolipoprotein (apo)A-I promoter. The effect of constitutively increased SR-BI expression on plasma HDL and non-HDL lipoproteins and apolipoproteins was characterized. There was an inverse correlation between SR-BI expression and apoA-I and HDL cholesterol levels in transgenic mice fed either mouse chow or a diet high in fat and cholesterol. An unexpected finding in the SR-BI transgenic mice was the dramatic impact of the SR-BI transgene on non-HDL cholesterol and apoB whose levels were also inversely correlated with SR-BI expression. Consistent with the decrease in plasma HDL and non-HDL cholesterol was an accelerated clearance of HDL, non-HDL, and their major associated apolipoproteins in the transgenics compared with control animals. These in vivo studies of the effect of SR-BI overexpression on plasma lipoproteins support the previously proposed hypothesis that SR-BI accelerates the metabolism of HDL and also highlight the capacity of this receptor to participate in the metabolism of non-HDL lipoproteins.  (+info)

Specific interaction of oxidized low-density lipoprotein with macrophage-derived foam cells isolated from rabbit atherosclerotic lesions. (5/1441)

Interaction of oxidized LDL (OxLDL) with macrophage-derived foam cells is one of the key events in the development and progression of atherosclerosis. To study this interaction, macrophage-derived foam cells were isolated from rabbit atherosclerotic lesions and the expression of scavenger receptors for OxLDL was examined. Atherosclerosis was induced in rabbits by denudation of the large arteries, followed by a hypercholesteremic diet. Macrophage-derived foam cells, characterized by immunostaining with an RAM-11 antibody (a macrophage marker), contained a high content of intracellular lipid. Maximal binding of radiolabeled OxLDL to isolated macrophage-derived foam cells (1652+/-235 ng 125I-OxLDL/mg of cell protein) was 20-fold higher compared with Bmax values of monocytes. Levels of association of OxLDL to macrophage-derived foam cells isolated from atherosclerotic lesions 12 weeks after denudation were >3-fold higher compared with the levels expressed by macrophage-derived foam cells isolated after 6 weeks. Association of 125I-OxLDL could be completely blocked by OxLDL, and partially by acetylated LDL and polyinosinic acid, indicating the presence of a specific binding site for OxLDL on macrophage-derived foam cells. The induction of scavenger receptors for OxLDL on macrophage-derived foam cells during the development of atherosclerosis, as described in this study, may facilitate the lipid accumulation in macrophage-derived foam cells, as observed in advanced atherosclerotic lesions.  (+info)

Scavenger receptor BI mediates the selective uptake of oxidized cholesterol esters by rat liver. (6/1441)

High density lipoprotein (HDL) can protect low density lipoprotein (LDL) against oxidation. Oxidized cholesterol esters from LDL can be transferred to HDL and efficiently and selectively removed from the blood circulation by the liver and adrenal in vivo. In the present study, we investigated whether scavenger receptor BI (SR-BI) is responsible for this process. At 30 min after injection, the selective uptake of oxidized cholesterol esters from HDL for liver and adrenal was 2.3- and 2.6-fold higher, respectively, than for native cholesterol esters, whereas other tissues showed no significant difference. The selective uptake of oxidized cholesterol esters from HDL by isolated liver parenchymal cells could be blocked for 75% by oxidized LDL and for 50% by phosphatidylserine liposomes, both of which are known substrates of SR-BI. In vivo uptake of oxidized cholesterol esters from HDL by parenchymal cells decreased by 64 and 81% when rats were treated with estradiol and a high cholesterol diet, respectively, whereas Kupffer cells showed 660 and 475% increases, respectively. These contrasting changes in oxidized cholesterol ester uptake were accompanied by similar contrasting changes in SR-BI expression of parenchymal and Kupffer cells. The rates of SR-BI-mediated selective uptake of oxidized and native cholesterol esters were analyzed in SR-BI-transfected Chinese hamster ovary cells. SR-BI-mediated selective uptake was 3.4-fold higher for oxidized than for native cholesterol esters (30 min of incubation). It is concluded that in addition to the selective uptake of native cholesterol esters, SR-BI is responsible for the highly efficient selective uptake of oxidized cholesterol esters from HDL and thus forms an essential mediator in the HDL-associated protection system for atherogenic oxidized cholesterol esters.  (+info)

Selection-dominant and nonaccessible epitopes on cell-surface receptors revealed by cell-panning with a large phage antibody library. (7/1441)

To generate antibodies to defined cell-surface antigens, we used a large phage antibody fragment library to select on cell transfectants expressing one of three chosen receptors. First, in vitro panning procedures and phage antibody screening ELISAs were developed using whole live cells stably expressing the antigen of interest. When these methodologies were applied to Chinese hamster ovary (CHO) cells expressing one of the receptors for a neuropeptide, somatostatin, using either direct cell panning or a strategy of depletion or ligand-directed elution, many different pan-CHO-cell binders were selected, but none was receptor specific. However, when using direct panning on CHO-cells expressing the human membrane protein CD36, an extraordinary high frequency of antigen-specific phage antibodies was found. Panning on myoblasts expressing the rat homologue of CD36 revealed a similar selection dominance for anti-(CD36). Binding of all selected 20 different anti-(CD36) phage was surprisingly inhibited by one anti-(CD36) mAb CLB-IVC7, which recognizes a functional epitope that is also immunodominant in vivo. Similar inhibition was found for seven anti-(rat) CD36 that cross-reacted with human CD36. Our results show that, although cells can be used as antigen carriers to select and screen phage antibodies, the nature of the antigen target has a profound effect on the outcome of the selection.  (+info)

Uptake and fate of class B scavenger receptor ligands in HepG2 cells. (8/1441)

Class B scavenger receptors (SR-Bs) interact with native, acetylated and oxidized low-density lipoprotein (LDL, AcLDL and OxLDL), high-density lipoprotein (HDL3) and maleylated BSA (M-BSA). The aim of this study was to analyze the catabolism of CD36- and LIMPII-analogous-1 (CLA-1), the human orthologue for the scavenger receptor class B type I (SR-BI), and CD36 ligands in HepG2 (human hepatoma) cells. Saturation binding experiments revealed moderate-affinity binding sites for all the SR-B ligands tested with dissociation constants ranging from 20 to 30 microg.mL-1. Competition binding studies at 4 degrees C showed that HDL and modified and native LDL share common binding site(s), as OxLDL competed for the binding of 125I-LDL and 125I-HDL3 and vice versa, and that only M-BSA and LDL may have distinct binding sites. Degradation/association ratios for SR-B ligands show that LDL is very efficiently degraded, while M-BSA and HDL3 are poorly degraded. The modified LDL degradation/association ratio is equivalent to 60% of the LDL degradation ratio, but is three times higher than that of HDL3. All lipoproteins were good cholesteryl ester (CE) donors to HepG2 cells, as a 3.6-4.7-fold CE-selective uptake ([3H]CE association/125I-protein association) was measured. M-BSA efficiently competed for the CE-selective uptake of LDL-, OxLDL-, AcLDL- and HDL3-CE. All other lipoproteins tested were also good competitors with some minor variations. Hydrolysis of [3H]CE-lipoproteins in the presence of chloroquine demonstrated that modified and native LDL-CE were mainly hydrolyzed in lysosomes, whereas HDL3-CE was hydrolyzed in both lysosomal and extralysosomal compartments. Inhibition of the selective uptake of CE from HDL and native modified LDL by SR-B ligands clearly suggests that CLA-1 and/or CD36 are involved at least partially in this process in HepG2 cells.  (+info)

*Plasmodium falciparum erythrocyte membrane protein 1

The first human RBC antigen was reported in 1986. Howard's team found that the antigens from Gambian children, who were ... It binds with CD36 on endothelial cells. Only group B and C proteins are able to bind, and that too with only those having CIDR ... The antigen was large and appeared to be different in size in different strains of P. falciparum obtained from night monkey ( ... Both antigens bind to cultured skin cancer (melanoma) cells. But the researchers failed to confirm whether or not the protein ...

*CD36 antigen

... is a transmembrane, highly glycosylated, glycoprotein expressed by monocytes, macrophages, platelets, ... CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http ... mpr.nci.nih.gov/prow/). Adhesion molecule CD36 InterPro: IPR005428 Lysosome membrane protein II InterPro: IPR005429 CD36; ... CD36 recognises oxidized low density lipoprotein, long chain fatty acids, anionic phospholipids, collagen types I, IV and V, ...

*FYN

"Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular ... FYN has been shown to interact with: ADD2, BCAR1, C-Raf, CBLC, CD36, CD44, CDH1, CHRNA7, CTNND1, CBL, CSF1R, DLG4, Dystroglycan ... Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (September 1991). "Membrane glycoprotein IV (CD36) is physically ...

*YES1

"Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular ... 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human ...

*CD36

... is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface ... CD36 is also known as glycoprotein IV (gpIV) or glycoprotein IIIb (gpIIIb) in platelets and gives rise to the Naka antigen. The ... In a group of 250 black American blood donors 6 (2.4%) were found to be Naka antigen negative. CD36 deficiency may be a cause ... Subsequent studies have shown that CD36 found on the surface of platelets. This antigen is recognized by the monoclonal ...

*List of MeSH codes (D12.776.157)

... antigens, cd36 MeSH D12.776.157.530.400.150 -- calcium channels MeSH D12.776.157.530.400.150.400 -- calcium channels, l-type ... antigens, cd98 heavy chain MeSH D12.776.157.530.200.374.750.500.625 -- antigens, cd98 light chains MeSH D12.776.157.530.200.500 ... antigens, cd98 heavy chain MeSH D12.776.157.530.200.500.500.500.300 -- antigens, cd98 light chains MeSH D12.776.157.530.200.500 ... leukocyte l1 antigen complex MeSH D12.776.157.125.750.500.100 -- calgranulin a MeSH D12.776.157.125.750.500.200 -- calgranulin ...

*List of MeSH codes (D12.776.395)

... antigens, cd36 MeSH D12.776.395.550.625.298 -- integrin alpha2beta1 MeSH D12.776.395.550.625.379 -- integrin alpha5beta1 MeSH ... antigens, cd22 MeSH D12.776.395.550.200.098 -- antigens, cd24 MeSH D12.776.395.550.200.131 -- antigens, cd31 MeSH D12.776. ... 395.550.200.170 -- antigens, cd146 MeSH D12.776.395.550.200.175 -- antigens, cd164 MeSH D12.776.395.550.200.200 -- cadherins ... antigens, cd43 MeSH D12.776.395.560.631.650.264 -- antigens, cd164. ...

*List of MeSH codes (D23)

... antigens, cd31 MeSH D23.050.301.264.035.134 --- antigens, cd34 MeSH D23.050.301.264.035.136 --- antigens, cd36 MeSH D23.050. ... antigens, cd31 MeSH D23.101.100.110.134 --- antigens, cd34 MeSH D23.101.100.110.136 --- antigens, cd36 MeSH D23.101.100.110.138 ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... hla-b antigens MeSH D23.050.301.500.450.380.383 --- hla-b7 antigen MeSH D23.050.301.500.450.380.385 --- hla-b8 antigen MeSH ...

*List of MeSH codes (D12.776.543)

... antigens, cd36 MeSH D12.776.543.585.400.150 -- calcium channels MeSH D12.776.543.585.400.150.400 -- calcium channels, l-type ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 -- antigens, cd79 MeSH D12.776.543.750.705.816.824 -- receptors, antigen, ... antigens, cd22 MeSH D12.776.543.550.200.124 -- antigens, cd24 MeSH D12.776.543.550.200.131 -- antigens, cd31 MeSH D12.776. ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 -- antigens, cd30 MeSH D12.776.543.750.705.852.760.097 -- antigens, cd40 ...

*Bruce Beutler

CD36 is a sensor of diacylglycerides. Nature 433(7025):523-7, 2005 Tabeta, K., et al. The Unc93b1 mutation 3d disrupts ... exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nature Immunol. 7(2):156-64, 2006 Beutler, B ...

*Macrophage-activating factor

A MAF can also alter the ability of macrophages to present MHC I antigen, participate in Th responses, and/or affect other ... Interferon-gamma Interleukin 4 TNF alpha CD36 It has been suggested that MAF can be formed by probiotic bacteria in a yoghurt ... Pathogenic antigens can bind to toll-like receptors that stimulate macrophage activation and response. Examples include heat ... July 2012). "CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues". ...

*Russell J. Howard

CD36 peptides enhance or inhibit CD36-Thrombospondin binding. A two-step process of ligand-receptor interaction. J. Biol. Chem ... At the NIH he patented discovery, characterisation and cloning of a novel gene encoding a soluble malarial antigen, called ... While working at Maxygen Inc., he and his colleagues developed three patents for the following technologies: antigen library ... Howard, R. J. and Pasloske, B.L. Target antigens for asexual malaria vaccine development. Parasitology Today, 9: 369-372, 1993 ...

*Human genetic resistance to malaria

There are four alleles of the gene which encodes the antigen, Ge-1 to Ge-4. Three types of Ge antigen negativity are known: Ge- ... Adhesion of P. falciparum-infected red blood cells to CD36 is enhanced by the cerebral malaria-protective SAO trait . Higher ... elliptocytosis and loss of the Gerbich antigen and the Duffy antigen. These names refer to various proteins, enzymes, and the ... "Duffy Negative Antigen Is No Longer a Barrier to Plasmodium vivax - Molecular Evidences from the African West Coast (Angola and ...

*Outline of immunology

Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... SCARB1 SCARB2 CD36 (SCARB3) Others CD68 LOX-1 Formyl peptide receptors (FPRs) FPR1 FPR2 FPR3 Cytoplasmic PRRs NOD-like ... T cells Antigen receptor - T cell receptor (TCR) Subunits - [email protected] / [email protected] / [email protected] / [email protected] Co-receptors CD8 (CD8α / CD8β) CD4 ... B cells Antigen receptor - B cell receptor (BCR) Subunits- Immunoglobulin heavy chain / Immunoglobulin light chain Co-receptors ...

*MFGE8

1996). "Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented ... and CD36 with a major milk protein, beta-casein". Biochim. Biophys. Acta. 1334 (2-3): 182-90. doi:10.1016/s0304-4165(96)00091-8 ...

*Phagocytosis

Active transport Antigen presentation Antigen presenting cell Emperipolesis Endosymbionts in protists Paracytophagy Phagoptosis ... which themselves then bind to other receptors on the macrophage such as CD36 and alpha-v beta-3 integrin. Defects in apoptotic ...

*Foam cell

... s may form around leaked silicone from breast implants, inhaled organic antigens and some drugs. Hotamisligil, G.S. ( ... CD36 and SR-A located on the macrophage surface. Coated-pit endocytosis, phagocytosis and pinocytosis are all responsible for ...

*CD81

... interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36. It forms a signal transduction ... 1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic ... is associated on the cell surface with the Leu-13 antigen". J. Immunol. 145 (7): 2207-13. PMID 2398277. Matsumoto AK, Martin DR ...
Kawecki C., et al. Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex. Cellular and Molecular Life Sciences. 1-17. 29/11/2018.. In addition to its critical role in lysosomes for catabolism of sialoglycoconjugates, NEU1 is expressed at the plasma membrane and regulates a myriad of receptors by desialylation, playing a key role in many pathophysiological processes. Here, we developed a proteomic approach dedicated to the purification and identification by LC-MS/MS of plasma membrane NEU1 interaction partners in human macrophages. Already known interaction partners were identified as well as several new candidates such as the class B scavenger receptor CD36. Interaction between NEU1 and CD36 was confirmed by complementary approaches. We showed that elastin-derived peptides (EDP) desialylate CD36 and that this effect was blocked by the V14 peptide, which blocks the interaction between bioactive ...
Proatherogenic hyperlipidemic states not only increase the risk of cardiovascular disease in the chronic kidney disease (CKD) population but also increase the risk of worsening renal function.1,2 Given the implications that accelerating both cardiovascular disease and renal dysfunction have on morbidity and mortality in this population, investigating the mechanisms of renal glomerular and tubulointerstitial injury observed in this setting is a topic of great interest.. Recently, the apolipoprotein E (apoE) null mouse has been used as a model of hyperlipidemic renal injury and offers a valuable tool to study such mechanisms.3 On this genetic background, we and others have demonstrated that the class B scavenger receptor CD36 is a key molecule in mediating the inflammation, insulin resistance, and atherogenesis involved in proatherogenic hyperlipidemic states.4-7 CD36 is expressed on a variety of cell types including monocytes and macrophages8 and proximal tubular cells (PTCs)9 and recognizes ...
Results Compared with NL, hepatic mRNA and protein levels of FAT/CD36 were significantly higher in patients with NAS (median fold increase 0.84 (range 0.15-1.61) and 0.66 (range 0.33-1.06), respectively); NASH (0.91 (0.22-1.81) and 0.81 (0.38-0.92), respectively); HCV G1 without steatosis (0.30 (0.17-1.59) and 0.33 (0.29-0.52), respectively); and HCV G1 with steatosis (0.85 (0.15-1.98) and 0.87 (0.52-1.26), respectively). In contrast to NL, FAT/CD36 was predominantly located at the plasma membrane of hepatocytes in patients with NAFLD and HCV G1 with steatosis. A significant correlation was observed between hepatic FAT/CD36 expression index and plasma insulin levels, insulin resistance (HOMA-IR) and histological grade of steatosis in patients with NASH (r=0.663, r=0.735 and r=0.711, respectively) and those with HCV G1 with steatosis (r=0.723, r=0.769 and r=0.648, respectively). ...
Background: Bendavia, a cell-permeable and mitochondrial inner membrane-targeting peptide, is known to protect mitochondrial cristae structure, reduce oxidative stress and promote electron transport. Altered energy metabolism substrate utilization and myocardial remodeling have been implicated as important factors in heart failure. Our hypothesis was that Bendavia regulates glucose transporter 4 (GLU4) and fatty acid transporter (CD36) expression and prevents hypertrophy in the noninfarcted border zone.. Methods: Rats with left coronary artery ligation were treated with Bendavia (3 mg/kg/day), water or sham operation. At 6 weeks, heart samples were harvested from shams, MI/BZ=border zone (2 mm noninfarcted tissue) of water-treated infarcted hearts and MI/BZ+Bendavia = border zone of Bendavia-treated hearts.. Results: qRT-PCR analysis showed that GLU4 and CD36 gene expression were decreased by 51%, p=0.0003 and 44%, p=0.0011, respectively, in the MI/BZ group vs sham. Importantly, Bendavia ...
Cigarette smoking (CS) accounts for 175,000 annual CV deaths in US. CKD is a major CV risk factor. Epidemiologically link between CS proteinuria and progression of diabetic and of hypertensive nephropathy is documented. We showed that Nicotine (NIC) in concentrations achieved in CS and E- smokers a)Increased proteinuria (100%) renal Nox4 & Nitrotyrosine in diabetic db/db mice (AJP 10) and b) Promoted in human macrophages O2- production and foam cell formation associated with upregulation of B scavenger receptor CD36 and oxLDL uptake (AJP13). Podocytes (POD) are vulnerable to diabetes and to hypertension; POD injury results in detachment and glomerulosclerosis. We demonstrated in human POD NIC receptors α2, 3,4 and β3 Methods: We treated human POD with NIC, 100nmol/L, a concentration attained in serum of CS and E-Cigarettes smokers, and determined O2- production with lucigening; some POD were pre-incubated with Hexametonium: blocker of NIC receptors; DPI: inhibitor of NADPH; Catalase: ...
LIMPII兔多克隆抗体(ab106519)可与小鼠, 大鼠, 人样本反应并经WB, IHC, ICC/IF实验严格验证,被5篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Class B scavenger receptor type I (SR-BI), a multiligand membrane protein, exists in various organs and cell types. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. Unlike interstitially localized Leydig ce
Gene: [07q112/CD36] antigen CD36 (collagen type I receptor, thrombospondin receptor); collagen type I receptor (CD36); thrombospondin receptor (CD36); glycoprotein IIIb; glycoprotein IV (platelet); platelet glycoprotein IV deficiency; [THBSR ...
Issued Prepublication Requirements The Joint ommission has approved the following revisions for prepublication. While revised requirements are published in the semiannual updates to the print manuals (as
Apache OpenOffice nudi kompletan radni okvir dozvoljavajući da bude obogaćen. OpenOffice dozvoljava i „proširenja" i „šablone". Proširenje (extension) je alat od drugog proizvođača (third party) koji donosi nove funkcije OpenOffice-u. To može da se uradi preko „add-on" dodataka (komponenata koje se integrišu u grafički korisnički interfejs - GUI OpenOffice-a), „add-in" dodataka (komponenata koje pružaju nove formule u Računu (Calc) OpenOffice-a), angažovanih od strane UNO paketa. Šabloni su unapred podešena dokumenta dizajnirana za određene namene ...
Sigma-Aldrich offers abstracts and full-text articles by [Christiane Danilo, Jorge L Gutierrez-Pajares, Maria Antonietta Mainieri, Isabelle Mercier, Michael P Lisanti, Philippe G Frank].
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Cholesterol accumulation in macrophages occurs independently of LDL receptors and results from the uptake of retained and modified apoB-containing lipoproteins by scavenger receptors,1 which are not under a cholesterol-feedback regulation. The scavenger receptor superfamily is composed of many members with diverse structures, expression patterns, and functions.2 Scavenger receptor class A types I and II, the class B scavenger receptors (CD36 and CD68), LOX-1, and possible others are implicated in the unrestrictive cholesteryl ester accumulation in macrophages, lipid droplet formation and ultimately, atherosclerosis.3 As intracellular cholesterol levels increase, endogenous cholesterol biosynthesis and LDL receptor expression are repressed through inhibition of the sterol regulatory element-binding protein (SREBP) pathway.4 This mechanism is insufficient to maintain cholesterol homeostasis in the face of continued cholesterol uptake by scavenger-receptor-dependent mechanisms. As mammalian cells ...
Compare Scavenger Receptor Class B, Member 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Recent studies revealed that scavenger receptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis. However, the mechanisms underlying this protection remain largely unknown. In this study, using Scarb1I179N mice, a mouse model specifically deficient in hepatic SR-BI, we report that hepatic SR-BI protects against cecal ligation and puncture (CLP)-induced sepsis as shown by 75% fatality in Scarb1I179N mice, but only 21% fatality in C57BL/6J control mice. The increase in fatality in Scarb1I179N mice was associated with an exacerbated inflammatory cytokine production. Further study demonstrated that hepatic SR-BI exerts its protection against sepsis through its role in promoting LPS clearance without affecting the inflammatory response in macrophages, the glucocorticoid production in adrenal glands, the leukocyte recruitment to peritoneum or the bacterial clearance in liver. Our findings reveal hepatic SR-BI as a critical protective factor in sepsis and point out that promoting hepatic ...
In the USA smoking is associated with 175,000 annual deaths due to cardiovascular disease and 30% of all deaths caused by heart attack. The pathogenic roles of stable compounds in the gas phase of cigarette smoke continue to be investigated. Here we confirmed the pro-atherogenic property of nicotine in vivo and investigated the pathway and mechanism in vitro and in vivo. In human THP1-differentiated macrophages, nicotine at "physiological" concentrations (100 nmol/L) found in smokers serum increased mRNA and protein expression of the B scavenger receptor CD36 by 116±19% without affecting the expression of proinflammatory cytokines. These effects of nicotine were mediated by a common signaling pathway dependent on reactive oxygen species, PKCδ phosphorylation and PPARγ. Antioxidants as well as non-cholinergic nicotinic blockers prevented nicotine-induced CD36 upregulation. OxLDL increased expression of CD36 and proinflammatory cytokines including TNF-α, MCP-1, IL6, and CXCL9, by 2-4 fold ...
Çöpçü reseptör sınıf B, tip I (İngilizce Scavenger receptor class B type I kısaltması SR-BI olarak değinilir), çeşitli hücrelerde görülen bir entegral membran proteinidir. Yüksek yoğunluklu lipoproteinlerdeki (HDL) kolesteril esterin karaciğer tarafından alınmasını sağlar. Vücuttaki diğer dokulardan karaciğere doğru, vücuttan atılmak üzere, giden kolesterolün bu hareketi bu süreç sayesinde sürdürülür. Kolesterolün bu gidişi "ters kolesterol taşıması" (İng. Reverse cholesterol transport) olarak adlandırılır ve ateroskleroz oluşumuna karşı koruyucu bir mekanizma olarak işler (ateroskleroz kalp hastalığı ve akut inmenin başlıca nedenidir).[1][2]. ...
Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T., Leece, L., Clayton, Z., Yuen, S., Robertson, S., Lam, M., Celermajer, D., Ng, M., Bursill, C. (2016). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes, 65(10), 3091-3103. [More Information] ...
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
A - Tilt: 3° - Segments: 1(43-52), 2(78-88), 3(92-101), 4(126-135), 5(140-148), 6(208-216), 7(221-229), 8(274-281), 9(287-295), 10(325-334), 11(339-348), 12(367-375), 13(381-390), 14(410-421 ...
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine (OC) pesticide, chlordecone (CD) stimulated biliary excretion of exogenous CH up to 3-fold, and further, that increased biliary excretion was not associated with changes in ATP-binding cassette transporter G8 (ABCG8) or scavenger receptor class B type I (SR-BI). In rodents, hepatic basolateral SR-BI is important in controlling plasma lipoprotein levels and cholesterol (CH) homeostasis, with major roles in reverse CH transport (RCT) and biliary excretion. The hepatic ABCG5/G8 heterodimer is a membrane transporter present on the apical surfaces of hepatocytes, and also plays a key role in biliary CH ...
The hallmark of the human atherosclerotic plaque is the presence of lipid-laden macrophages, or foam cells. However, many macrophage subsets are found within atherosclerotic lesions and it is not well understood how monocytes differentiate into these subsets. We focused on characterizing macrophages derived in vitro from human peripheral blood monocytes treated with IL-15, IL-4 or IL-10. We show these macrophages to have differing phenotypes: CD209+CD64+, CD209+CD23+, or CD209+CD163+ for macrophages derived from IL-15, IL-4, or IL-10 respectively. To characterize the macrophage subsets ability to become foam cells we measured their uptake of fluorescently-labeled oxidized LDL (oxLDL). IL-10 derived macrophages had the greatest amount of oxLDL uptake. We then investigated the mechanism of uptake and found that fucoidan, a class-A scavenger receptor competitor, significantly inhibited uptake of oxLDL in IL-10 cells. On the other hand a blocking antibody against the class B scavenger receptor, ...
Insulin resistance and type 2 diabetes are associated with low levels of high-density lipoprotein-cholesterol (HDL-C). The insulin-repressible FoxO transcription factors are potential mediators of insulins effect on HDL-C. FoxOs mediate a substantial portion of insulin-regulated transcription, and poor FoxO repression is thought to contribute to the excessive glucose production in diabetes. In this work, we show that mice with liver-specific triple FoxO knockout (L-FoxO1,3,4), which are known to have reduced hepatic glucose production, also have increased HDL-C. This was associated with decreased expression of HDL-C clearance factors, scavenger receptor class B type I (SR-BI) and hepatic lipase, and defective selective uptake of HDL-cholesteryl ester by the liver. The phenotype could be rescued by re-expression of SR-BI. These findings demonstrate that hepatic FoxOs are required for cholesterol homeostasis and HDL-mediated reverse cholesterol transport to the liver. ...
3NGH: In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1.
Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes. CD36 also influences various diseases, including angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia and obesity. Genetic deficiency of this protein results in significant changes in fatty acid and oxidized lipid uptake. Comparative CD36 amino acid sequences and structures and CD36 gene locations were examined using data from several vertebrate genome projects. Vertebrate CD36 sequences shared 53-100% identity as compared with 29-32% sequence identities with other CD36-like superfamily members, SCARB1 and SCARB2. At least eight vertebrate CD36 N-glycosylation sites were conserved
Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes. CD36 also influences various diseases, including angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia and obesity. Genetic deficiency of this protein results in significant changes in fatty acid and oxidized lipid uptake. Comparative CD36 amino acid sequences and structures and CD36 gene locations were examined using data from several vertebrate genome projects. Vertebrate CD36 sequences shared 53-100% identity as compared with 29-32% sequence identities with other CD36-like superfamily members, SCARB1 and SCARB2. At least eight vertebrate CD36 N-glycosylation sites were conserved
Rabbit polyclonal Scavenger Receptor BI + BII antibody validated for WB, IP, BL, ICC/IF and tested in Human and Mouse. Referenced in 3 publications. Immunogen…
recpmid,pmid=14709891,ti=Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: mechanisms and consequences ,au=Nakanishi Y; Shiratsuchi A,so=Biol Pharm Bull 2004; 27 (1): 13-6,ab=More than half of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa during mammalian spermatogenesis. These cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells, a testicular somatic cell type possessing phagocytic activity. We have investigated the mechanism by which Sertoli cells specifically recognize and phagocytose apoptotic spermatogenic cells and the consequences of phagocytosis. We showed by in vitro as well as in vivo analyses that Sertoli cells recognize apoptotic spermatogenic cells through the binding of their surface receptor, class B scavenger receptor type I, to phosphatidylserine that is expressed on the surface of spermatogenic cells during apoptosis. The inhibition of phagocytosis in live animals resulted in a decrease ...
Der Scavenger Receptor BI (SR-BI) vermittelt den selective lipid transfer von Cholesterol und Vitamin E aus HDL in die Leber. Die zelluläre Aufnahme verschiedener Lipide aus HDL über den selben Mechanismus, vermittelt durch den selben Rezeptor wirft die Frage auf, ob diese Aufnahmeprozesse einander beeinflussen. Aktuelle Forschungsergebnisse zeigen, daß die Aufnahme von neutralen Lipiden (Cholesterolester, Triacylglycerol) aus HDL in die Zelle von der Lipidzusammensetzung der Donorpartikel abhängen könnte. Wir untersuchten, ob der Vitamin-E-Gehalt von HDL die Aufnahme und den Efflux von Cholesterol in und aus HepG2-Zellen beeinflußt. Die Inkubation von HepG2-Zellen mit [3H]Cholesterol-markiertem HDL mit ansteigendem Vitamin-E-Gehalt ergab eine steigende Aufnahme von Vitamin E, während sich die Cholesterolaufnahme nicht veränderte. Der erhöhte zelluläre Gehalt an Vitamin E bewirkte eine Reduktion der PKC-Alpha- und SR-BI-Expression in Verbindung mit einem erniedrigten Cholesterolefflux ...
CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer ce
CD36 (bahasa Inggris: platelet glycoprotein, GPIV, glycoprotein IIIb, GPIIIB, leukocyte differentiation antigen CD36, CD36 antigen, SR-BI, PAS IV, PAS-4 protein, platelet collagen receptor, fatty acid translocase, thrombospondin receptor, FAT, TSPR) adalah glikoprotein transmembran yang tersandi pada kromosom 7 q11.2 oleh 15 ekson dan mempunyai ekspresi pada permukaan sel keping darah, endotelium, makrofaga, DC, adiposit, striated muscle cells, dan hematopoietic cells.[1]. Cacat pada CD36 dapat menginduksi penyimpangan metabolisme asam lemak, glucose intolerance, aterosklerosis, tekanan darah tinggi, diabetes, kardiomiopati dan Alzheimer.[1]. ...
Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
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In the past several years, a number of cellular proteins have been identified as candidate entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection. Among these, the tetraspanin CD81 and scavenger receptor B type I (SR-BI), both of which localize to specialized plasma membrane domains enriched in cholesterol, have been suggested to be key players in HCV entry. In the current study, we used a recently developed in vitro HCV infection system to demonstrate that both CD81 and SR-BI are required for authentic HCV infection in vitro, that they function cooperatively to initiate HCV infection, and that CD81-mediated HCV entry is, in part, dependent on membrane cholesterol ...
Biobool provide the Human Scavenger receptor cysteine-rich domain-containing protein SCART1 ELISA Kit in Competitive price and high quanlity.
Our laboratory focusses on understanding how enveloped viruses attach to and enter cells to initiate viral replication and immunological responses that prevent infection with a vision to develop the worlds first preventative HCV vaccine for HCV elimination. Hepatitis C Virus contains two envelope glycoproteins, E1 and E2, that function as a heterodimer to mediate attachment and virus-cell membrane fusion. The viral glycoprotein E2 is primarily responsible for receptor binding to scavenger receptor class B type 1 (SRB1) and CD81. Antibodies directed towards regions of E2 that interfere with SRB1 or CD81 binding, block virus entry and are neutralizing antibodies. Therefore, understanding the structure of E2, how it interacts with both cellular receptors and how antibodies prevent these interactions are pivotal for vaccine development. Through our studies, we have identified a leading HCV vaccine candidate (HepSeeVaxDelta3) that we are currently assessing in preclinical studies as a recombinant ...
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008 ...
Human genetic platelet glycoprotein IV (CD36) deficiency may be related to the phenotypic expression of the metabolic syndrome and is frequently associated with atherosclerotic cardiovascular diseases. CD36 deficiency is relatively frequent in Asian and African populations. It also has been reported that CD36 deficiency might be linked with cardiomyopathy. This deficiency can be classified in two subgroups: the type I phenotype is characterized by platelets and monocytes/macrophages that exhibit CD36 deficiency; whereas in the type II phenotype, the surface expression of CD36 is lacking only in platelets, but expression is near normal in monocytes/macrophages ...
A brief communication: Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: Linking autoimmunity and atherosclerosis. Experimental Biology and Medicine. 2009 ...
An Estimation of Distribution Algorithm for Part Cell Formation Problem: 10.4018/978-1-4666-1945-6.ch040: The aim of this chapter is to propose a new heuristic for Machine Part Cell Formation problem. The Machine Part Cell Formation problem is the important step
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Pictures of orobanchaceae wildflowers of West USA. Cluster of elephant heads (pedicularis groenlandica) - Paradise Meadows, Lassen Volcanic National Park, California. High resolution version
The overall goal of this research was to determine the effectiveness of reconstituted high-density lipoprotein (rHDL) nanoparticles as a drug delivery system against metastatic triple negative breast cancer (TNBC). TNBC patients have a less favorable prognosis than those with hormone positive breast cancers. TNBC does not respond to current endocrine treatment. Consequently, the five- year survival rate for patients with metastatic TNBC is | 30%. The studies performed here were intended to fill a void in the treatment of metastatic TNBC with the use of targeted reconstituted high-density lipoprotein (rHDL) nanoparticles, an innovative approach. The rHDL nanoparticles are small, biocompatible, non-immunogenic complexes, targeted to the high-density lipoprotein receptor (scavenger receptor class B type 1 [SR-B1]). While most malignant cells and tumors overexpress the SR-B1 receptor, its expression levels are nearly undetectable in most normal tissues. These findings present the opportunity to exploit a
TY - JOUR. T1 - Platelet membrane glycoprotein IV (CD36) is involved in arachidonic acid induced-platelet aggregation. AU - Dutta-Roy, Asim K. AU - Crosbie, Lynn. AU - Gordon, Margaret Jane. AU - Campbell, Fiona Margaret. PY - 1996/5/1. Y1 - 1996/5/1. KW - Antibodies, Monoclonal. KW - Antigens, CD. KW - Antigens, CD36. KW - Arachidonic Acid. KW - Blood Platelets. KW - Humans. KW - Platelet Aggregation. M3 - Article. C2 - 8736825. VL - 24. SP - 167S. JO - Biochemical Society Transactions. JF - Biochemical Society Transactions. SN - 0300-5127. IS - 2. ER - ...
Abstract: : Purpose: To determine whether human RPE cells in culture express the following reverse cholesterol transport proteins: scavenger receptor BI (SR-BI), scavenger receptor BII (SR-BII), and ATP-binding cassette protein A1 (ABCA1); to confirm this expression in fixed human tissue sections. Methods: Primary cultures of human RPE cells were grown for at least one week at confluence prior to RNA isolation or immunofluorescent staining. RNA expression was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) of total cellular RNA using primer sets specific to human SR-BI, SR-BII or ABCA1. Immunofluorescent staining was performed using a biotinylated secondary antibody and fluoresceinated avidin. Either affinity- purified antibodies specific to SR-BI and SR-BII peptides, or commercially available antiserum to ABCA1 were used as primary antibodies, with the appropriate controls. SR-BI, SR-BII and ABCA1 proteins were visualized in RPE cells by standard and confocal ...
Recently, fatty acid transport across the plasma membrane has been shown to be a key process that contributes to the regulation of fatty acid metabolism in the heart. Since AMP kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D: -ribofurano
T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28) - Pipeline Review, H1 2017 Size and Share Published in 2017-06-13 Available for US$ 3500 at Researchmoz.us
The table below shows the top 100 pain related interactions that have been reported for fatty acid transport. They are ordered first by their pain relevance and then by number of times they were reported for fatty acid transport. Please click on the INT link to display more detailed information on each interaction. ...
Fats are just one component of food, whose presence does not determine whether it is healthy or not. The benefits of healthy fats should be framed within the context of a healthy diet and a food of good nutritional quality.. For example, if snacks or cookies contain olive oil, this does not mean that they are healthy, but it should be evaluated if each food is processed, high in salt, sugar, etc. Fried nuts with salt are not healthy, although they contain omega fats, because the high temperatures deteriorate the healthy fats.. In short, whenever you talk about the properties of fats, this should be framed within foods of quality (nuts without salt and without frying, unheated oils, etc.).. ...
Order Macrophage Scavenger Receptor 1 ELISA Kits for many Reactivities. Chicken, Cow, Guinea Pig and more. Compare Macrophage Scavenger Receptor 1 ELISA Kits and find the right product on antibodies-online.com.
Pyometra is the most common uterine disease in intact bitches leading to potentially life-threatening complications via the systemic inflammatory response syndrome (SIRS). Escherichia coli (E.coli) is the most abundant isolated pathogen causing pyometra. In a previous study the investigators characterized endometrial epithelial foam cells (EEFCs) in the canine endometrial surface occurring in metestrus, the cyclic stage with the most common presence of pyometra. They identified a specialized receptor named scavenger receptor class B1 (SR-B1) expressed in EEFCs. SR-B1 is relevant for lipid-uptake and thereby involved in EEFC formation. SR-B1 is also a strong binding partner for E.coli, and a significant upregulation of SR-B1 in pyometra affected canine uteri was identified. The hypothesis in this study is that blocking of SR-B1 in EEFCs can be used as supportive non-invasive pyometra treatment. Binding capacity of an adherent pyometra-related E.coli strain will be tested in the presence of the functional
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.
Scavenger receptor SR-BI has been implicated in HDL-dependent atheroprotective mechanisms. We report the generation of an SR-BI conditional knockout mouse model in which SR-BI gene targeting by loxP site insertion produced a hypomorphic allele (hypomSR-BI). Attenuated SR-BI expression in hypomSR-BI mice resulted in 2-fold elevation in plasma total cholesterol (TC) levels. Cre-mediated SR-BI gene inactivation of the hypomorphic SR-BI allele in hepatocytes (hypomSR-BI-KOliver) was associated with high plasma TC concentrations, increased plasma free cholesterol/TC (FC/TC) ratio, and a lipoprotein-cholesterol profile typical of SR-BI-/- mice. Plasma TC levels were increased 2-fold in hypomSR-BI and control mice fed an atherogenic diet, whereas hypomSR-BI-KOliver and SR-BI-/- mice developed severe hypercholesterolemia due to accumulation of FC-rich, VLDL-sized particles. Atherosclerosis in hypomSR-BI mice was enhanced (2.5-fold) compared with that in controls, but to a much lower degree than in ...
The report provides comprehensive information on the "T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28)", targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in T Cell Specific Surface Glycoprotein CD28 (TP44 or CD28) targeted therapeutics development and features dormant and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and ...
Human T-cell surface glycoprotein CD3 epsilon chain (CD3E) ELISA Kit can measure Human T-cell surface glycoprotein CD3 epsilon chain in serum, blood, plasma, cell culture supernatant and other related supernatants and tissues.
COPYRIGHT 2016 BY EWHA WOMANS UNIVERSITY. ALL RIGHTS RESERVED 이화여자대학교 리포지터리는 국립중앙도서관 OAK 보급사업으로 구축되었습니다. Feedback ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Gene target information for SCARF1 - scavenger receptor class F member 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
Principal Investigator:長谷川 秀樹, Project Period (FY):2001 - 2002, Research Category:Grant-in-Aid for Young Scientists (B), Research Field:Virology
TY - JOUR. T1 - Characterization of low density and high density lipoprotein receptors in the rat corpus luteum and their regulation by gonadotropin. AU - Hwang, J.. AU - Menon, K. M J. PY - 1982. Y1 - 1982. UR - http://www.scopus.com/inward/record.url?scp=0020046436&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020046436&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0020046436. VL - 41. JO - Federation Proceedings. JF - Federation Proceedings. SN - 0014-9446. IS - 4. ER - ...
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1 ...
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Abcam provides specific protocols for Anti-Macrophage Scavenger Receptor I antibody (ab123946) : Immunohistochemistry protocols, Immunocytochemistry &…
Scavenger receptors (SRs) expressed on the activated macrophages in inflammation sites have been considered as the most interesting and important target biomarker for targeted drug delivery, imaging and therapy. In the present study, we fabricated the scavenger receptor-A (SR-A) targeted-photoactivatable nanoagents (termed as Ce6/DS-DOCA) by entrapping chlorin e6 (Ce6) into the amphiphilic dextran ...
If ketamine is upgraded to class B status then it would be in the same category of illegal drugs as amphetamines (speed) and barbiturates.. The legal penalty for possessing a class B drug can be up to five years in prison and an unlimited fine.. Supplying a class B drug to others, even if it is just to your friends, can lead to a prison sentence of up to 14 years in prison and an unlimited fine.. The Home Office and Department of Health are now considering the recommendation. ...
One-fifth of the pupils in class B and seven-eighth of those in class A were girls. After George reshuffled an equal number of pupils between the two classes, the number of boys in each class became the same as the number of girls. A total of 24 pupils were affected. How many pupils were there in both classes at first ...
SiliaMetS TAAcOH is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts. Best scavenger for: Ca, Co, Ir, Li, Mg, Ni, Os, Ru & Sc. Good scavenger for: Cr, Cs, Fe, Pd, Rh & Sn.
Rockin Green - Classic Rock Cloth Diaper Detergent - Remix by Rockin Green Soap in Diaper Accessories. Best prices and Free Shipping available. Shop
In general, transendothelial transport of proteins occurs by paracellular and transcellular pathways. We have previously demonstrated that aortic ECs bind, internalize, and resecrete apoA-I in a competed and temperature-dependent manner.9,10 Furthermore, we demonstrated that ABCA1 but not SR-BI modulates this process.9 In the present study, we extend these findings by showing that ECs also bind, internalize, and transport mature HDL, however, by characteristics that are distinct from those of transendothelial apoA-I transport. Most importantly, SR-BI and ABCG1 but not ABCA1 are rate-limiting for HDL transport.. The presence of different pathways for the transendothelial transport of apoA-I and HDL parallels the need of at least 2 distinct molecules interacting with cells of the arterial wall and other extravascular compartments. Lipid-free apoA-I dissociates from mature HDL as a result of HDL remodeling by lipid transfer proteins and lipases.12-14 Lipid-free apoA-I is important to mediate lipid ...
Enterovirus 71 (EV-A71) is now the most common neurotropic enterovirus. It causes Hand, Foot, and Mouth Disease (HFMD) and occasional outbreaks of severe neurological deficits in infected children. Current animal infection models using NHPs and rodents recapitulate some features of the wide clinical spectrum of illnesses induced by EV-A71 infection in humans. However, none of these recapitulates the key clinical and pathological features of EV-A71-induced neurogenic pulmonary edema (NPE) observed in majority of fatal human cases. We developed an infection model by inoculating one-week-old BALB/c mice with novel viral strains that productively infect rodent and primate cell lines. These mouse-cell-adapted (MCA-EV-A71) strains were generated by serial passage of a brainstem clinical isolate (EV71:BS) in a murine embryonic fibroblast (NIH/3T3) cell line. These strains infected rodent cell lines using the physiologically expressed EV-A71 receptor, SCARB2 (Scavenger Receptor Class B, Member-2). In ...
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MSR1 antibody (macrophage scavenger receptor 1) for ELISA, FACS, ICC/IF, IHC-F, IHC-P, WB. Anti-MSR1 pAb (GTX51749) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Creative Biostructure can provide customized Mempro™ cell-based protein production services for T-cell surface glycoprotein CD3 zeta chain
COMP/Thrombospondin-5 products available through Novus Biologicals. Browse our COMP/Thrombospondin-5 product catalog backed by our Guarantee+.

CD36 antigen - WikipediaCD36 antigen - Wikipedia

CD36 antigen is a transmembrane, highly glycosylated, glycoprotein expressed by monocytes, macrophages, platelets, ... CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http ... mpr.nci.nih.gov/prow/). Adhesion molecule CD36 InterPro: IPR005428 Lysosome membrane protein II InterPro: IPR005429 CD36; ... CD36 recognises oxidized low density lipoprotein, long chain fatty acids, anionic phospholipids, collagen types I, IV and V, ...
more infohttps://en.wikipedia.org/wiki/CD36_antigen

CD36 Antigens - Semantic ScholarCD36 Antigens - Semantic Scholar

CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS ... Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS ... CD36 Antigens. Known as: GPIIIb Platelet Glycoprotein, Scavenger Receptors, Class B, Type I, Glycoprotein IV, Platelet (More). ... CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer ...
more infohttps://www.semanticscholar.org/topic/CD36-Antigens/137988

Gene: [07q112/CD36] antigen CD36 (collagen type I receptor, thrombospondin receptor); collagen type I receptor (CD36);...Gene: [07q112/CD36] antigen CD36 (collagen type I receptor, thrombospondin receptor); collagen type I receptor (CD36);...

CD36. *Gene: [12^/CD36L1] antigen CD36 (collagen type I receptor, thrombospondin receptor)-like 1; CD36 and LIMPII analogous 1 ... Gene: [07q112/CD36] antigen CD36 (collagen type I receptor, thrombospondin receptor); collagen type I receptor (CD36); ... Gene: [04^/CD36L2] antigen CD36 (collagen type I receptor, thrombospondin receptor)-like 2; lysosomal integral membrane protein ... thrombospondin receptor (CD36); glycoprotein IIIb; glycoprotein IV (platelet); platelet glycoprotein IV deficiency; [THBSR ]. ...
more infohttp://medbiol.ru/medbiol/hugen/07q112_cd36.htm

HPMR - rec CD36, CD36 antigen (collagen type I receptor, thrombospondin receptor)HPMR - rec CD36, CD36 antigen (collagen type I receptor, thrombospondin receptor)

CD36 - CD36 ANTIGEN (COLLAGEN TYPE I RECEPTOR, THROMBOSPONDIN RECEPTOR) Family:Other External links: Entrez Gene, Omim. ... Receptor CD36 interacts with: non-gene ligand: hexarelin_a_synthetic_peptide[read more..]. CD36 mediates the cardiovascular ... 1992) transfected the sense and antisense cDNA of CD36 (glycoprotein IV) into melanoma cells and found that CD36 is a ... Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high ...
more infohttp://www.receptome.org/SearchDB/getGenePage.asp?Param=948&ProtId=1&ProtType=Receptor

TCDB » SEARCHTCDB » SEARCH

CD36 antigen; plasma membrane fatty acid transporter (Schwenk et al. 2010). Also called the scavenger receptor protein as it ... Direct interaction of CD36 with glycerol phospholipids has been demonstrated (Tsuzuki et al. 2017). CD36 plays a role in the ... 1] "CD36 is a receptor for oxidized low density lipoprotein." Endemann G.et.al. 7685021. [2] "The status, quality, and ...
more infohttp://tcdb.org/search/result.php?tc=9.B.39.1.1

CD36 peptide (ab66772) | AbcamCD36 peptide (ab66772) | Abcam

Buy our CD36 peptide. Ab66772 is a Synthetic peptide. Abcam provides free protocols, tips and expert support for WB and a 12 ... CD36 antigen. *CD36 antigen (collagen type I receptor, thrombospondin receptor). *CD36 molecule ... They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 ...
more infohttp://www.abcam.com/cd36-peptide-ab66772.html

cd36 Protein, CD36 molecule (thrombospondin receptor) - Creative BioMartcd36 Protein, CD36 molecule (thrombospondin receptor) - Creative BioMart

... leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); ... Cd36-8751R. Recombinant Rat Cd36, Fc tagged. HEK293. Rat. Fc. +Inquiry. CD36-96C. Recombinant Cynomolgus CD36, Fc tagged. ... CD36-2539HCL. Recombinant Human CD36 cell lysate. HEK293. Human. +Inquiry. CD36-2400MCL. Recombinant Mouse CD36 cell lysate. ... CD36-1236RCL. Recombinant Rat CD36 cell lysate. HEK293. Rat. +Inquiry. CD36-1109CCL. Recombinant Cynomolgus CD36 cell lysate. ...
more infohttps://www.creativebiomart.net/symbolsearch_cd36.htm

GO Gene ListGO Gene List

CD300A antigen. NM_170758. Gene Info. Cd36. CD36 antigen. NM_001159558. NM_007643. NM_001159555. NM_001159557. NM_001159556. ... CD47 antigen (Rh-related antigen, integrin-associated signal transducer). NM_010581. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Mm&GOID=0060627

Gene InfoGene Info

Cd36, CD36 antigen. Sequence ID:. NM_001159555. NM_001159556. NM_001159557. NM_001159558. NM_007643. ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=18628&LLNO=12491

rs3211938 - SNPediars3211938 - SNPedia

PMID 23844572] CD36 Gene Variants and Their Association with Type 2 Diabetes in an Indian Population ... Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. ... rs3211938, previously shown to influence malaria susceptibility, is documented to result in CD36 deficiency in a homozygous ... Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes ...
more infohttps://snpedia.com/index.php/Rs3211938

CD36 Antibody (MA1-19407)
                
                
		        
	CD36 Antibody (MA1-19407)

Invitrogen Anti-CD36 Monoclonal (TR9), Catalog # MA1-19407. Tested in Flow Cytometry (Flow) applications. This antibody reacts ... Protein Aliases: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor ... Cite CD36 Monoclonal Antibody (TR9). The following antibody was used in this experiment: CD36 Monoclonal Antibody (TR9) from ... In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. CD36 is preferentially found within lipid ...
more infohttps://www.thermofisher.com/antibody/product/CD36-Antibody-clone-TR9-Monoclonal/MA1-19407

CD36/SR-B3 Antibody (1A7) (NBP2-45250): Novus BiologicalsCD36/SR-B3 Antibody (1A7) (NBP2-45250): Novus Biologicals

Mouse Monoclonal Anti-CD36/SR-B3 Antibody (1A7). Platelet & Microvessel Marker. Validated: Flow, PAGE, ICC/IF. Tested ... Molecular weight of antigen: 80-90kDa. Functional Studies Order Ab without Azide. ... Home » CD36/SR-B3 » CD36/SR-B3 Antibodies » CD36/SR-B3 Antibody (1A7) ... Blogs on CD36/SR-B3. There are no specific blogs for CD36/SR-B3, but you can read our latest blog posts. ...
more infohttps://www.novusbio.com/products/cd36-sr-b3-antibody-1a7_nbp2-45250

KEGG BRITE: CD Molecules - Homo sapiens (human)KEGG BRITE: CD Molecules - Homo sapiens (human)

... receptor 1 K06259 CD36; CD36 antigen K06475 CD37; CD37 antigen K01242 CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20] K01510 ... CD79A antigen K06507 CD79B; CD79B antigen K05412 CD80; CD80 antigen K06508 CD81; CD81 antigen K06509 KAI1; CD82 antigen K06510 ... CD300 antigen K06719 CD300; CD300 antigen K06719 CD300; CD300 antigen K06719 CD300; CD300 antigen K06721 CLEC10A; C-type lectin ... CD96 antigen K08446 ADGRE5; CD97 antigen K06519 SLC3A2; solute carrier family 3, member 2 K06520 CD99; CD99 antigen K06521 ...
more infohttps://www.genome.jp/kegg-bin/get_htext?hsa04090+4486

anti-CD36 antibody | Mouse anti-Human CD36 Monoclonal Antibody (Clone 4H7)-NP 000063anti-CD36 antibody | Mouse anti-Human CD36 Monoclonal Antibody (Clone 4H7)-NP 000063

Mouse anti-Human CD36 Monoclonal Antibody (Clone 4H7)-NP_000063 (MBS831317) product datasheet at MyBioSource, Primary ... Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet ... Anti-CD36; Cluster of Differentiation 36; FAT; SCARB3; GP88; glycoprotein IV; gpIV; glycoprotein IIIb; gpIIIb; CD36; CD 36; CD- ... Product Description specifically for anti-CD36 antibody. Mouse monoclonal CD36 antibody Product Categories/Family for anti-CD36 ...
more infohttps://www.mybiosource.com/prods/Antibody/Monoclonal/CD36/datasheet.php?products_id=831317

Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1transgenic mice | Genome Biology | Full TextChanges in gene expression during the development of mammary tumors in MMTV-Wnt-1transgenic mice | Genome Biology | Full Text

... polyoma middle T antigen, C3(1)/simian virus 40 T/t antigen, and Wap-simian virus 40 T/t antigen transgenic mice using the 8.7k ... CD36, carbonic anhydrases, and solute carrier family members [7]. We note these genes in our table comparing hyperplastic ... Examples of the downregulated genes are CD59a antigen (two-fold), a potential p53 target [36], the Rb1 tumor suppressor gene, ... For immunohistochemistry, the sections were boiled for 15 minutes in 10 mmol/l citrate buffer of pH 6.0 (to unmask antigen ...
more infohttps://genomebiology.biomedcentral.com/articles/10.1186/gb-2005-6-10-r84

Article abstract | Medical Science MonitorArticle abstract | Medical Science Monitor

This study investigated whether CD36 activates the nucleotide-binding domain leucine-ric... ... CD36 plays a critical role in many sterile inflammatory diseases, including type 2 diabetes mellitus, atherosclerosis, and ... Keywords: Antigens, CD36, Inflammasomes, Inflammation, nephrotic syndrome, Podocytes. Full Text Order reprints Export Article. ... both of which were inhibited by co-treatment with an anti-CD36 antibody.. CONCLUSIONS: CD36 might play an important role in ...
more infohttps://www.medscimonit.com/abstract/index/idArt/909810

Effect of GPx-1 deficiency and MAPK signaling pathways  | Open-iEffect of GPx-1 deficiency and MAPK signaling pathways | Open-i

Antigens, CD36/genetics. *Atherosclerosis/genetics/metabolism. *Blotting, Western. *Female. *Gene Expression/drug effects ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3750037_pone.0072063.g003&req=4

KEGG PATHWAY: ko03320KEGG PATHWAY: ko03320

CD36 antigen. K08745 solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]. ...
more infohttps://www.kegg.jp/entry/ko03320

LIMP2 Antibody
		        
	LIMP2 Antibody

CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 ... antigen-like 2; CD36L2; HLGP85; LGP85; LIMP II; LIMPII; lysosomal integral membrane protein II; Lysosome membrane protein 2; ...
more infohttps://www.thermofisher.com/antibody/product/LIMP2-SCARB2-Antibody-Polyclonal/PA5-19111

RGD1565355 - PrimePCR Assay and Template | Life Science | Bio-RadRGD1565355 - PrimePCR Assay and Template | Life Science | Bio-Rad

Cd36 antigen-like Assay Type: Probe Assay Design: intron_spanning Application: Gene Expression Unique Assay ID: qRnoCIP0030642 ... Cd36 antigen-like Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dRnoEG5198512 Info: EG; Same primer pair ... Cd36 antigen-like Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5201155 Info: FAM; Same primer pair ... Cd36 antigen-like Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5201156 Info: HEX; Same primer pair ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/rgd1565355-rat

Sibley Memorial Hospital - Fingerprint
     - Johns Hopkins UniversitySibley Memorial Hospital - Fingerprint - Johns Hopkins University

CD36 Antigens Primary Health Care Pharmaceutical Preparations Baltimore Class B Scavenger Receptors ...
more infohttps://jhu.pure.elsevier.com/en/organisations/sibley-memorial-hospital-3/fingerprints/

SR-BI Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen 100 µg;
 | Fisher ScientificSR-BI Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen 100 µg; | Fisher Scientific

CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor, thrombospondin ...
more infohttps://www.fishersci.com/shop/products/anti-scarb1-polyclonal/PIPA520756

Code System ConceptCode System Concept

CD36 - Cluster of differentiation antigen 36 Current Synonym true false 1235672017 Cluster of differentiation antigen 36 ... Lymphocyte antigen CD36 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD36 (substance). ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=91464006

CD36 - Beckman CoulterCD36 - Beckman Coulter

CD36 expression occurs in different types of cells, including mammary epithelial cells, endothelial cells monocytes, ... The CD36 antigen (platelet GPIV, or GPIIIb) is a generic term for a family of glycoproteins with molecular weights ranging from ... CD36 Antigen. The CD36 antigen (platelet GPIV, or GPIIIb) is a generic term for a family of glycoproteins with molecular ... The FA6-152 monoclonal antibody, raised against fetal erythrocytes, recognizes the CD36 family of antigens on platelets and ...
more infohttps://www.beckman.com.au/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/cd36
  • CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. (thermofisher.com)
  • CD36 expression occurs in different types of cells, including mammary epithelial cells, endothelial cells monocytes, macrophages, platelets, megakaryocytes and early erythroid cells. (beckman.com.au)
  • rs3211938, previously shown to influence malaria susceptibility, is documented to result in CD36 deficiency in a homozygous subject. (snpedia.com)
  • Similar to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. (thermofisher.com)
  • CD36 plays a critical role in many sterile inflammatory diseases, including type 2 diabetes mellitus, atherosclerosis, and primary nephrotic syndrome. (medscimonit.com)
  • CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. (novusbio.com)
  • This study investigated whether CD36 activates the nucleotide-binding domain leucine-rich repeat-containing family, pyrin domain-containing-3 (NLRP3) inflammasome and promotes podocytes apoptosis in primary nephrotic syndrome. (medscimonit.com)
  • CD36 might play an important role in podocyte apoptosis by activating the NLRP3 inflammasome in primary nephrotic syndrome. (medscimonit.com)
  • Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. (snpedia.com)
  • mRNA and protein expression of CD36 and NLRP3 was quantified by real-time PCR and Western blotting, respectively. (medscimonit.com)
  • CD36 expression was also examined in nephrotic mouse kidney tissue by immunohistochemistry and immunofluorescence. (medscimonit.com)
  • CD36 expression was increased in nephrotic mouse kidney tissue. (medscimonit.com)