Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Expression of the cell adhesion molecules on leukocytes that demarginate during acute maximal exercise. (1/1480)
The pulmonary vascular bed is an important reservoir for the marginated pool of leukocytes that can be mobilized by exercise or catecholamines. This study was designed to determine the phenotypic characteristics of leukocytes that are mobilized into the circulation during exercise. Twenty healthy volunteers performed incremental exercise to exhaustion [maximal O2 consumption (VO2 max)] on a cycle ergometer. Blood was collected at baseline, at 3-min intervals during exercise, at VO2 max, and 30 min after exercise. Total white cell, polymorphonuclear leukocyte (PMN), and lymphocyte counts increased with exercise to VO2 max (P < 0.05). Flow cytometric analysis showed that the mean fluorescence intensity of L-selectin on PMN (from 14.9 +/- 1 at baseline to 9.5 +/- 1.6 at VO2 max, P < 0.05) and lymphocytes (from 11.7 +/- 1.2 at baseline to 8 +/- 0.8 at VO2 max, P < 0.05) decreased with exercise. Mean fluorescence intensity of CD11b on PMN increased with exercise (from 10.2 +/- 0.6 at baseline to 25 +/- 2.5 at VO2 max, P < 0.002) but remained unchanged on lymphocytes. Myeloperoxidase levels in PMN did not change with exercise. In vitro studies showed that neither catecholamines nor plasma collected at VO2 max during exercise changed leukocyte L-selectin or CD11b levels. We conclude that PMN released from the marginated pool during exercise express low levels of L-selectin and high levels of CD11b. (+info)Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration. (2/1480)
PURPOSE: Previous studies have shown that ovariectomy and hypophysectomy cause regression of the lacrimal gland and have implicated androgens as trophic hormones that support the gland. The purposes of this study were to test the hypothesis that glandular regression after ovariectomy is due to apoptosis, to identify the cell type or types that undergo apoptosis, to survey the time course of the apoptosis, and to determine whether ovariectomy-induced apoptosis could be prevented by dihydrotestosterone (DHT) treatment. METHODS: Groups of sexually mature female New Zealand White rabbits were ovariectomized and killed at various time periods up to 9 days. Additional groups of ovariectomized rabbits were treated with 4 mg/kg DHT per day. At each time period, sham-operated rabbits were used as controls. Lacrimal glands were removed and processed for analysis of apoptosis as assessed by DNA fragmentation and for morphologic examination. DNA fragmentation was determined using the TdT-dUTP terminal nick-end labeling assay and by agarose gel electrophoresis. Labeled nuclei were quantified by automated densitometry. Sections were also stained for RTLA (rabbit thymic lymphocyte antigen), rabbit CD18, and La antigen. Morphology was evaluated by both light and electron microscopy. RESULTS: The time course of apoptosis exhibited two phases, a rapid and transient phase and a second prolonged phase. A transient phase peaked at approximately 4 to 6 hours after ovariectomy. The values for degraded DNA as a percentage of total nuclear area were 4.29%+/-0.79% and 4.26%+/-0.54%, respectively. The values for sham-operated controls examined at the same time periods were 1.77%+/-0.08% and 0.82%+/-0.21%, respectively. The percentage of degraded DNA at 24 hours after ovariectomy was not different from controls examined at the same interval after sham operation. The percentage of degraded DNA 6 days after ovariectomy was significantly increased (8.5%+/-2.4%), compared with sham-operated animals at the same time period (0.68%+/-0.03%). DNA laddering was more pronounced after ovariectomy. Dihydrotestosterone treatment in ovariectomized rabbits suppressed the increase in DNA degradation. Morphologic examination of lacrimal gland sections indicated that ovariectomy caused apoptosis of interstitial cells rather than acinar or ductal epithelial cells. Tissue taken 4 hours and 6 days after ovariectomy showed nuclear chromatin condensation principally in plasma cells. Increased numbers of macrophages were also evident. Significant levels of cell degeneration and cell debris, characteristic of necrosis, were observed in acinar regions 6 days after ovariectomy. Dihydrotestosterone prevented this necrosis. Increased numbers of RTLA+, CD18+, and La+ interstitial cells were also evident 6 days after ovariectomy. In addition, ovariectomy increased La expression in ductal cells. Dihydrotestosterone treatment prevented the increase in numbers of lymphoid cells and La expression. Dihydrotestosterone also promoted the appearance of mitotic figures in acinar cells and increased the sizes of acini by 43% (P < 0.05). CONCLUSIONS: Glandular atrophy observed after ovariectomy is likely to proceed by necrosis of acinar cells rather than apoptosis. This process begins with an apparent time lag after a rapid phase of interstitial cell apoptosis. These processes are accompanied by increased lymphocytic infiltration. These results suggest that a critical level of androgen is necessary to maintain lacrimal gland structure and function and that a decrease in available androgen below this level could trigger lacrimal gland apoptosis and necrosis, and an autoimmune response. Because apoptotic and necrotic cell fragments may be sources of autoantigens that can be processed and presented to initiate an autoimmune reaction, we surmise that cell death triggered by androgen withdrawal may trigger an autoimmune response such as that encountered in Sjogren's syndrome. (ABSTRACT TRUNCATED) (+info)Antibodies to CD18 influence neutrophil migration through extracellular matrix. (3/1480)
Mac-1 (CD11b/CD18) is known to be involved in neutrophil (PMN) adhesion to endothelial cells and extracellular matrix. Although antibodies to CD 18 are being tested for therapy in humans, their role in PMN migration through the extracellular matrix is unknown. We used direct visualization to quantify PMN motility through reconstituted, three-dimensional gels of collagen type I. Gels were prepared with different concentrations of collagen (ranging from 0.1 to 1.0 mg/mL) and PMN migration was examined in the presence and absence of antibodies to CD18 (anti-CD18), with and without stimulation by N-formyl peptides. In low-concentration gels (<0.6 mg/mL), anti-CD18 had a significant influence on PMN migration, increasing motility in unstimulated PMN by 90% at 0.3 mg/mL collagen, and decreasing motility in N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated PMN by 70% at 0.4 mg/mL collagen. But antiCD18 had no effect on the rate of cell migration through high-concentration collagen gels (>0.6 mg/mL). PMN migration through collagen gels is CD18-dependent but only under conditions of high hydration, suggesting that CD18-mediated effects (e.g., adhesion to gel fibers) are only important when the fiber density is relatively low. Anti-CD18 inhibited, but did not eliminate, the adhesion of fMLP-stimulated PMN to the surface of collagen gels, suggesting that cells use multiple mechanisms for gaining traction within the gel. Because of the multiple modes of interaction between motile cells and the deformable fiber matrix, blockade of one component, such as CD18, can enhance the rate of cell migration under one set of conditions, and inhibit under another. (+info)Characterization of beta2 (CD18) integrin phosphorylation in phorbol ester-activated T lymphocytes. (4/1480)
Integrins are transmembrane proteins involved in cell-cell and cell-extracellular-matrix interactions. The affinity and avidity of integrins for their ligands change in response to cytoplasmic signals. This 'inside-out' activation has been reported to occur also with beta2 integrins (CD18). The beta2 integrin subunit has previously been shown to become phosphorylated in T lymphocytes on cytoplasmic serine and the functionally important threonine residues after treatment with phorbol esters or on triggering of T-cell receptors. We have now characterized the phosphorylation of beta2 integrins in T-cells in more detail. When T-cells were activated by phorbol esters the phosphorylation was mainly on Ser756. After inhibition of serine/threonine phosphatases, phosphorylation was also found in two of the threonine residues in the threonine triplet 758-760 of the beta2 cytoplasmic domain. Activation of T-cells by phorbol esters resulted in phosphorylation in only approx. 10% of the integrin molecules. Okadaic acid increased this phosphorylation to approx. 30% of the beta2 molecules, assuming three phosphorylation sites. This indicates that a strong dynamic phosphorylation exists in serine and threonine residues of the beta2 integrins. (+info)Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin. (5/1480)
Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates neutrophils to adhere closely to, but not to migrate into, fibrin gels. Leukotriene B4 (LTB4) stimulates neutrophils to adhere loosely to and to migrate through fibrin gels. We report that alpha5beta1 integrins regulate the different migratory behaviors on fibrin gels of neutrophils in response to these chemoattractants. fMLP, but not LTB4, activated neutrophil beta1 integrins, as measured by binding of mAb 15/7 to an activation epitope on the beta1 integrins. Antibodies or peptides that block alpha5beta1 integrins prevented fMLP-stimulated neutrophils from forming zones of close apposition on fibrin and reversed fMLP's inhibitory effect on neutrophil chemotaxis through fibrin. In contrast, neither peptides nor antibodies that block beta1 integrins affected the capacity of LTB4-stimulated neutrophils to form zones of loose apposition or to migrate through fibrin gels. These results suggest that chemoattractants generate at least two different messages that direct neutrophils, and perhaps other leukocytes, to accumulate at specific anatomic sites: a general message that induces neutrophils to crawl and a specific message that prepares neutrophils to stop when they contact appropriate matrix proteins for activated beta1 integrins. (+info)Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids. (6/1480)
The aim of this work was to study the expression of beta 1- and beta 2-integrins, CR1, CD44 and Fc gamma receptors on peripheral blood monocytes in RA. The expression of these receptors was measured by flow cytometry, before and after treatment with low-dose prednisolone. Expression of the same receptors was also measured before and after treatment with metyrapone, a substance that inhibits the synthesis of cortisol in the adrenals. The expression of the beta 2-integrins CD11a, CD11b and CD18, of CD35 (CR1), and of Fc gamma RII and Fc gamma RI (CD32 and CD64) on monocytes was elevated in the RA patients compared with healthy controls, while the expression of the beta 1-integrins (CD29, CD49d, CD49f) was unaffected. A significant correlation between monocyte expression of CD64 and C-reactive protein (CRP), and blood platelet count, respectively, was found in the group of patients with RA. After 4-6 weeks of treatment with low-dose prednisolone, the expression on the monocytes of CD11a, CD11b, CD18, CD35, CD32 and CD64 was normalized. A significant correlation (r = 0.64, P = 0.02) was found between the decrease in expression of CD11b and clinical improvement after prednisolone treatment. Two days of metyrapone treatment, which significantly lowered the serum cortisol levels, elevated the expression of CD35 and CD49f. Priming of peripheral monocytes seems to be one of the mechanisms behind the recruitment of monocytes to the rheumatoid synovium. One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes. (+info)Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains. (7/1480)
We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule-1 that was mediated by Mac-1 (alphaMbeta2) but not lymphocyte function-associated antigen-1 (LFA-1; alphaLbeta2). In contrast, staining for an activation epitope revealed a rapid and transient up-regulation of LFA-1 activity by monocyte chemotactic protein-1 (MCP-1) in monocytes and Jurkat CCR2 chemokine receptor transfectants or by stromal-derived factor-1alpha in Jurkat cells. Differential kinetics for activation of Mac-1 (sustained) and LFA-1 (transient) avidity in response to stromal-derived factor-1alpha were confirmed by expression of alphaM or alphaL in alphaL-deficient Jurkat cells. Moreover, expression of chimeras containing alphaL and alphaM cytoplasmic domain exchanges indicated that alpha cytoplasmic tails conferred the specific mode of regulation. Coexpressing alphaM or chimeras in mutant Jurkat cells with a "gain of function" phenotype that results in constitutively active LFA-1 demonstrated that Mac-1 was not constitutively active, whereas constitutive activity was mediated via the alphaL cytoplasmic tail, implying the presence of distinct signaling pathways for LFA-1 and Mac-1. Transendothelial chemotaxis of monocytes in response to MCP-1 was dependent on LFA-1; however, Mac-1 was involved at MCP-1 concentrations stimulating its avidity, showing differential contributions of beta2 integrins. Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains. (+info)Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is through CD11b/CD18. (8/1480)
Interaction of LPS with monocytes and neutrophils is known to occur via CD14 and is strongly enhanced by LPS-binding protein (LBP). Integrins as well as CD14 play a role in the interaction of erythrocytes (E) coated with LPS or whole Gram-negative bacteria with phagocytes. We reasoned that the density of LPS on a particle is an important determinant in these interactions. Therefore, E were coated with different concentrations of LPS (ELPS). The binding of these ELPS to neutrophils was evaluated by flow cytometry. Simultaneously, we measured fMLP receptor expression to evaluate neutrophil activation. ELPS only bound to neutrophils in the presence of LBP. Blocking CD14 inhibited both activation and binding, whereas blocking complement (C) receptor 3 (CR3) inhibited binding but not activation. TNF activation restored ELPS binding in CD14-blocked cells but not in cells in which CR3 was blocked. Salmonella minnesota did bind to neutrophils independent of CR3 or CD14. The addition of LBP enhanced binding twofold, and this surplus was dependent upon CD14 but not on CR3. We conclude that ELPS interact with neutrophils via CD14, initially giving rise to cell activation; subsequently, binding is solely mediated by activated CR3. (+info)
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Antigenic escape
Additionally tumors can escape antigen-directed therapies by loss or down-regulation of the associated antigens, as well ... doi:10.1158/2159-8290.CD-18-0442. ISSN 2159-8274. PMID 30135176. Upadhyay, Ranjan; Boiarsky, Jonathan A.; Pantsulaia, Gvantsa; ... Different antigens are able to escape through a variety of mechanisms. For example, the African trypanosome parasites are able ... Some antigens may even target pathways different than those the vaccine had originally intended to target. Recent research on ...
Integrin alpha L
CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ... Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... CD11a+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGAL Info with links in the Cell ... Qu A, Leahy DJ (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. ...
Framework region
"Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen". Molecular ... These CDRs are in direct contact with the antigen and are involved in binding antigen, while the framework regions support the ... residues that are in contact with the antigen and those not in contact with the antigen. Framework residues that come in ... If the CDR regions have high affinity for the epitope of antigen, it has been found to be more effective to have a more rigid ...
Intercellular adhesion molecule
They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in ...
Gamma delta T cell
CD18, CD54). Thus activated Vγ9Vδ2 T cells behave like APCs (γδ T-APC) and present antigens to αβ T cells. This leads to turn ... The antigens recognized by non-Vδ2 T cells expanded in the above infectious contexts have not been characterized, but the fact ... It is still not clear whether these non-peptidic antigens bind directly to the Vγ9/Vδ2 TCR or if a presenting element exists. ... However, none of the known antigen-presenting molecules like MHC class I and II or CD1 are required for γδ T cell activation ...
Leukocyte adhesion deficiency-1
... and respiratory burst Flow cytometry with monoclonal antibodies is used to screen for deficiencies of CD18. Because the CD18 ... including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The ... This gene encodes CD18, a protein present in several cell surface receptor complexes found on white blood cells, ...
CD11
... b/CD18) present on macrophages that is also called Macrophage-1 antigen (CR3) and αMβ2 integrin. CD11c/CD18 also called ... For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin Mac1 ... In cell biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 ...
Aggregatibacter actinomycetemcomitans
Leukotoxin A: kills granulocytes, monocytes, and other white blood cells expressing integrin beta-2 (CD18) Cytolethal ... cells Inhibition of granulocyte functions Resistant to complement-mediated killing Lipopolysaccharides Surface antigens Heat ...
List of MeSH codes (D23)
... antigens, cd8 MeSH D23.050.301.264.894.113 - antigens, cd13 MeSH D23.050.301.264.894.118 - antigens, cd18 MeSH D23.050.301.264. ... antigens, cd14 MeSH D23.050.301.264.035.115 - antigens, cd15 MeSH D23.050.301.264.035.118 - antigens, cd18 MeSH D23.050.301.264 ... antigens, cd14 MeSH D23.101.100.110.115 - antigens, cd15 MeSH D23.101.100.110.118 - antigens, cd18 MeSH D23.101.100.110.119 - ... antigens, cd8 MeSH D23.101.100.894.113 - antigens, cd13 MeSH D23.101.100.894.118 - antigens, cd18 MeSH D23.101.100.894.126 - ...
Integrin beta 2
Binding of CD18 and CD11 results in the formation of Lymphocyte Functions Associated Antigen 1 (LFA-1), a protein found on B ... CD18+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell Migration ... CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating ... thus destroying the antigen. In humans, lack of functional CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a ...
Outline of immunology
CD18 Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... ITGB3 Fibrinogen receptor Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Fibronectin receptor: Integrin alpha2beta1 ... CD18 CR4 - Heterodimer: CD11c / CD18 CRIg (Complement receptor of the immunoglobulin family) Anaphylatoxin receptors C3a ...
Antibody-dependent cellular cytotoxicity
Usually, a target cell line expressing a certain surface-exposed antigen is incubated with antibody specific for that antigen. ... These bacteria target the CD18 portion of leukocytes, which has historically been shown to impact ADCC in adhesion-deficient ... ADCC is also important in the use of vaccines, as creation of antibodies and the destruction of antigens introduced to the host ... Frey, Joachim (2019/12). "RTX Toxins of Animal Pathogens and Their Role as Antigens in Vaccines and Diagnostics". Toxins. 11 ( ...
Integrin alpha M
Integrin+alphaM at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Todd RF, Petty HR (May 1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors". The ... Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily ( ...
Lymphocyte function-associated antigen 1
LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16. Leukocyte ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ... The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. ...
Macrophage-1 antigen
... (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T ... CR3 CD11b/CD18 Macrophage 1 antigen (Mac-1) Macrophage Todd R (1996). "The continuing saga of complement receptor type 3 (CR3 ... Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b ( ... Wagner C, Hänsch GM, Stegmaier S, Denefleh B, Hug F, Schoels M (April 2001). "The complement receptor 3, CR3 (CD11b/CD18), on T ...
ICAM-1
It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into ... Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (Jan 1985). "Chromosome mapping of cell membrane antigens ... Huang C, Springer TA (Aug 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... ICAM-1 has been shown to interact with CD11a, EZR and CD18. GRCh38: Ensembl release 89: ENSG00000090339 - Ensembl, May 2017 ...
Duffy antigen system
This antigen along with other blood group antigens was used to identify the Basque people as a genetically separate group.[49] ... Because the Duffy antigen is uncommon in those of Black African descent, the presence of this antigen has been used to detect ... The Fy4 antigen, originally described on Fy (a-b-) RBCs, is now thought to be a distinct, unrelated antigen and is no longer ... The Duffy antigen is expressed in greater quantities on reticulocytes than on mature erythrocytes.[21] While the Duffy antigen ...
Integrin beta 3
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ... CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
List of MeSH codes (D12.776.543)
... antigens, cd18 MeSH D12.776.543.750.705.408.200.500 - antigens, cd29 MeSH D12.776.543.750.705.408.200.750 - integrin beta3 MeSH ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ... antigens, cd22 MeSH D12.776.543.550.200.124 - antigens, cd24 MeSH D12.776.543.550.200.131 - antigens, cd31 MeSH D12.776.543.550 ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 - antigens, cd30 MeSH D12.776.543.750.705.852.760.097 - antigens, cd40 MeSH ...
CDH8
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ...
CDH1 (gene)
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin". Molecular and ...
VCAM-1
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
P-selectin
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ...
CD44
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.[5] CD44 has been referred to as HCAM (homing cell ... The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. ... Indian blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ...
FHL2
... has been shown to interact with: Androgen receptor, BRCA1, CTNNB1, CD18, CD29, CD49c, CREB1, EIF6, FHL3, IGFBP5, ITGA7, ... rise in circulatory prostate-specific antigen (PSA) levels after surgical or radiography treatment) FHL2 expression is ...
CD90
It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in ... It has been shown to interact with the leukocyte integrin Mac1 (CD11b/CD18) and may play a role in leukocyte homing and ... The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search ... Reif AE, Allen JM (1964). "The AKR thymic antigen and its distribution in leukemias and nervous tissue". J. Exp. Med. 120 (3): ...
CD11c, a enciclopedia libre
1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18 ... Human CD Antigen Chart. *ITGAX Info with links in the Cell Migration Gateway ... A cadea alfa X de integrina combínase coa cadea beta 2 (CD18 ou ITGB2) para formar unha integrina específica de leucocitos ... Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by ...
CD63
... antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of ... Skubitz KM, Campbell KD, Iida J, Skubitz AP (October 1996). "CD63 associates with tyrosine kinase activity and CD11/CD18, and ... Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional ... Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC (February 1991). "CD63 antigen. A novel lysosomal ...
Gwendalyn J. Randolph
Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node- ... role of intercellular adhesion molecule 1 and the CD11/CD18 integrins. Journal of Experimental Medicine, 183(2):451-462. PMCID ... are involved in the immune response by acting as a site for macrophages and dendritic cells to uptake antigens. The results ... Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. ...
Integrin alpha X
CD11c+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... 1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". ... Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by ... Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced ...
Faktor aktivacije B-ćelija
CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin ...
CD30
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... results from cDNA cloning and sequence comparison of the CD30 antigen from different sources". Molecular Immunology. 31 (17): ...
Imunostimulator
CD18 (Erlizumab) • CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) • CD23 (Lumiliksimab) • CD40 (Teneliksimab, Toralizumab) • ... Induction of Potent and Long-Lasting T-Cell Responses against Cancer Antigens". Cancer Research 62: 1477-1480. ... "A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in ...
Меланотрансферрин - Википедия
Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same ... Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. (англ.) // Hum. ... Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3 ... Rose T. M., Plowman G. D., Teplow D. B., etal. Primary structure of the human melanoma-associated antigen p97 ( ...
CEACAM5
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5. External IDs. HomoloGene: 128801 GeneCards: ... Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". ...
ABCG2
The protein also carries the Jr(a) antigen, which defines the Junior blood group system.[9] ...
CLEC12A - Википедия
van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ...
C-C chemokine receptor type 6
2002). "CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells". J. ... Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes ... This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may ... dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens". J. Immunol. 167 (11): ...
Adalimumab
"Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen". Bio/Technology. 12 ... drug were found by guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen ...
CD15
It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ... CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 ...
LAG3
A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... antigen processing and presentation of exogenous peptide antigen via MHC class II. ... antigen binding. • transmembrane signaling receptor activity. • MHC class II protein binding. Cellular component. • membrane. • ...
CD97
CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
Interferon tip I - Википедија, слободна енциклопедија
CD18 (Erlizumab) • CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) • CD23 (Lumiliksimab) • CD40 (Teneliksimab, Toralizumab) • ... ćelije bile identifikovane kao najpotentniji proizvođači tipa I interferona u odgovoru na antigen, i bile su nazvani prirodne ...
Salmonella
The serotype or serovar, is a classification of Salmonella into subspecies based on antigens that the organism presents. It is ... Salmonellae are also able to breach the intestinal barrier via phagocytosis and trafficking by CD18-positive immune cells, ... Serotyping is done by mixing cells with antibodies for a particular antigen. It can give some idea about risk. A 2014 study ... and flagellar H antigens (the Kauffman-White classification). The full name of a serotype is given as, for example, Salmonella ...
Imunosupresant - Википедија
Nakon presađivanja (transplantacije) organa, telo skoro uvek „odbaci" novi organ usled razlike ljudskih leukocit antigen ... CD18 (Erlizumab) • CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) • CD23 (Lumiliksimab) • CD40 (Teneliksimab, Toralizumab) • ...
Dipeptidyl peptidase-4
"Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ...
Immunosuppressive drug
Past this period CD3 blocks the TCR-antigen binding and causes conformational change or the removal of the entire TCR3/CD3 ... The IL-2a (CD25, T-cell activation antigen, TAC) is expressed only by the already-activated T lymphocytes. Therefore, it is of ... The antilymphocyte (ALG) and antithymocyte antigens (ATG) are being used. They are part of the steroid-resistant acute ... Monoclonal antibodies are directed towards exactly defined antigens. Therefore, they cause fewer side-effects. Especially ...
CD154
B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In ... Grewal, IS; Xu, J; Flavell, RA (7 December 1995). "Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand". ...
CD36 - Википедия
antigen processing and presentation of peptide antigen via MHC class I. • antigen processing and presentation of exogenous ... antigen processing and presentation of exogenous peptide antigen via MHC class I. • lipoprotein transport. • negative ... peptide antigen via MHC class I, TAP-dependent. • platelet degranulation. • MyD88-dependent toll-like receptor signaling ...
CXCR5 - Википедия
... uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate (англ.) // Blood (англ ...
CD8
In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell antigen interactions. ... This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen- ... Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex ...
SLAMF1
antigen binding. • virus receptor activity. • protein binding. • transmembrane signaling receptor activity. • identical protein ...
C5a receptor
CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ...
Alternative complement pathway
This change in shape allows the binding of plasma protein Factor B, which allows Factor D to cleave Factor B into Ba and Bb. Bb remains bound to C3(H2O) to form C3(H2O)Bb. This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although only produced in small amounts, can cleave multiple C3 proteins into C3a and C3b. The complex is believed to be unstable until it binds properdin, a serum protein. The addition of properdin forms the complex C3bBbP, a stable compound which can bind an additional C3b to form alternative pathway C5-convertase. The C5-convertase of the alternative pathway consists of (C3b)2BbP (sometimes referred to as C3b2Bb). After the creation of C5 convertase (either as (C3b)2BbP or C4b2a3b from the classical pathway), the complement system follows the same path regardless of the means of activation (alternative, classical, or lectin). C5-convertase cleaves C5 into C5a and C5b. C5b binds sequentially to C6, C7, C8 and ...
CD74 - Википедия
CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens-associated invariant chainIa antigen ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ... Machamer C.E., Cresswell P. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens (англ.) // ...
Antigens, CD18 | Profiles RNS
CD18" by people in this website by year, and whether "Antigens, CD18" was a major or minor topic of these publications. ... "Antigens, CD18" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Antigens, CD18" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Antigens, CD18". ...
Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to...
Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to ... Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to ... Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to ... Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to ...
CD18 - Beckman Coulter
CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with one of four α subunits. ... CD11/CD18) are the major adhesion molecule family of leukocytes. Most leukocytes express one or more members of this family. ... CD18 Antigen. The beta2 integrins (CD11/CD18) are the major adhesion molecule family of leukocytes. Most leukocytes express one ... CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with one of four α subunits. The four alpha ...
PerCP/Cyanine5.5 anti-human CD18 Antibody anti-CD18 - TS1/18
CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. ... Antigen Details Structure Integrin, type I transmembrane glycoprotein, associates with CD11a, CD11b, or CD11c, 90-95 kD ... CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains ... CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. ...
Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies...
Cutting Edge: Productive HIV-1 Infection of Dendritic Cells via Complement Receptor Type 3 (CR3, CD11b/CD18) | The Journal of...
White cell differentiation antigens. W. Knapp, and B. Dörken, and W. R. Gilks, and E. P. Rieber, and R. E. Schmidt, and H. ... Surface expression of CD11b and CD18 of imMDCs and maMDCs at day 7. Shaded histograms represent the binding of CD11b- and CD18- ... CD11b/CD18; CR4, CD11c/CD18), and C3d, C3dg (CR2, CD21). HIV-1 infection of human lymphocytes and monocytes/macrophages is ... Cutting Edge: Productive HIV-1 Infection of Dendritic Cells via Complement Receptor Type 3 (CR3, CD11b/CD18). Zsuzsa Bajtay, ...
A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function...
... a possible CD2/lymphocyte function-associated antigen-1 functional association in humans, Immunology, vol. 99, no. 3, pp. 440- ... T1 - A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function- ... A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function- ... title = "A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte ...
The wild boar ( Sus scrofa ) Lymphocyte function-associated antigen-1 (CD11a/CD18) receptor: cDNA sequencing, structure...
This study reports the sequencing of the wild boar beta2-integrin CD11a and CD18 cDNAs. Predicted CD11a and CD18 subunits share ... Besides these strong overall similarities, wild boar and domestic pig LFA-1 differ by 2 (CD18) and 1 or 3 (CD11a) substitutions ... CD11a/CD18, alphaLbeta2), expressed on all leukocytes, is essential for many adhesive functions of the immune system. ... with a larger interspecies conservation for the CD18 than the CD11a. ...
Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway
CD11b Antigen / metabolism * CD18 Antigens / genetics * CD18 Antigens / immunology * CD18 Antigens / metabolism ... TDM-induced Mincle signaling on neutrophils increased cell adherence by enhancing F-actin polymerization and CD11b/CD18 surface ... coactivation of the Mincle and TLR2 pathways by TDM and Pam3CSK4 treatment synergistically induced CD11b/CD18 surface ...
Anti-CD18 antibody [MEM-48] (Biotin) (ab28093) | Abcam
Mouse monoclonal CD18 antibody [MEM-48] conjugated to Biotin. Validated in Flow Cyt and tested in Human. Cited in 1 publication ... Ab28093 reacts with an epitope located in the region encoded by aa 534-546 in cysteine rich repeat 3 of the CD18 antigen. ... Anti-CD18 antibody [MEM-48], prediluted (Allophycocyanin) (ab40914) *Anti-CD18 antibody [MEM-48] - Low endotoxin, Azide free ( ... Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte- ...
Immunopathogenesis of psoriasis - Sabat - 2007 - Experimental Dermatology - Wiley Online Library
CD11a/CD18; αL:β2) (T cells) and (ii) the interactions between lymphocyte function-associated antigen 3 (LFA-3; CD58) (DC) and ... Sensitization phase - antigen processing and presentation. The initial step of every specific immune reaction to an antigen (Ag ... Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997: 389: 978-981. * ... Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J Immunol 2006: 176: 5730-5734. * ...
Integrin beta 2/CD18 Antibody (MEM-48) [Biotin] (NBP1-44612): Novus Biologicals
Mouse Monoclonal Anti-Integrin beta 2/CD18 Antibody (MEM-48) [Biotin]. Validated: Flow. Tested Reactivity: Human. 100% ... integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit) ... include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha ... CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response ...
Integrin beta 2/CD18 Antibody (YFC118.3) [Janelia Fluor® 549] (NB200-610JF549): Novus Biologicals
Rat Monoclonal Anti-Integrin beta 2/CD18 Antibody (YFC118.3) [Janelia Fluor® 549]. Validated: Flow, ICC/IF, IHC, IHC-Fr. Tested ... integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit) ... include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha ... This recognises the human CD18 cell surface antigen, the integrin beta2 subunit. CD18 is expressed by the majority of ...
Frontiers | Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity...
Human Leukocyte Antigen - antigen D Related; HR, heart rate; HRmax, maximum heart rate; HRR, heart rate reserve; HSC, ... CD18, cluster of differentiation 18; CD19, cluster of differentiation 19; CD28, cluster of differentiation 28; CD45RA, cluster ... ACSM, American College of Sports Medicine; APC, antigen presenting cell; CCR7, C-C chemokine receptor type 7; CD4, cluster of ... Dendritic cells differentiate from monocytes to become professional antigen presenting cells (APCs). They form a part of the ...
Recombinant Human CD18 protein (ab114283) | Abcam
Buy our Recombinant Human CD18 protein. Ab114283 is a full length protein produced in Wheat germ and has been validated in WB, ... Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C. *Leukocyte cell adhesion molecule CD18 ... 12.5% SDS-PAGE analysis of CD18 protein (ab114283). Stained with Coomassie Blue. ...
Frontiers | Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies |...
Here, we generate a bispecific 4-1BB-agonistic trimerbody targeting the carcinoembryonic antigen (CEA) that is highly expressed ... Here, we generate a bispecific 4-1BB-agonistic trimerbody targeting the carcinoembryonic antigen (CEA) that is highly expressed ... doi: 10.1158/2159-8290.CD-18-0367. PubMed Abstract , CrossRef Full Text , Google Scholar ... CEA is a non-internalizing antigen (17), which may be advantageous compared to other antigens that are rapidly internalized ...
Luke O'Neill : School of Biochemistry and Immunology - Trinity College Dublin
Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease | Science Signaling
Mac-1: A macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9, 301-306 (1979).. ... Indeed, blocking CD11b/CD18 and its ligands (7-9) and ablation of the genes encoding CD11b (3) or CD18 (10) decrease the ... The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the αM (CD11b) and β2 (CD18) subunits, is critical for ... described an agonist of CD11b/CD18, termed IMB-10, that targets the αA domain of CD11b/CD18 (32). We compared the relative ...
Anti-Monkey Integrin beta 2 antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
ITGB2 / CD18 (ITGB2 Antibody Abstract) Background Name/Gene ID: ITGB2. Family: Integrin. Synonyms: ITGB2, CD18 antigen, CD18, ... Antigen Integrin beta 2 (ITGB2) Antibodies show synonyms for this antigen * CD18 ... A synthetic peptide corresponding to a sequence at the C-terminus of human CD18(732-748aa LREYRRFEKEKLKSQWN), identical to the ...
Cytomegalovirus induced PMN adherence in relation to an ELAM-1 antigen present on infected endothelial cell monolayers. -...
The results obtained after incubation of PMN with mAb IB4 (against CD18) suggest that the adhesion of PMN to uninfected ... In turn this activation antigen ELAM-1 binds with its putative ligand present on the PMN membrane. The virus-induced PMN ... Cytomegalovirus induced PMN adherence in relation to an ELAM-1 antigen present on infected endothelial cell monolayers.. Span ... mAb ENA1 reacts with an inducible endothelial surface antigen which has characteristics similar to those of ELAM-1. Incubation ...
Dermal neutrophil emigration in WT and CD18−/− mice | Open-i
Dermal neutrophil emigration in WT and CD18−/− mice 6 h after topical application of 2% croton oil. Emigrated neutrophils were ... Antigens, CD18/biosynthesis/genetics/physiology*. *Cell Movement/immunology*. *Leukocyte-Adhesion Deficiency Syndrome/genetics/ ... or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants). Peripheral blood of CD18-/- mutants contained 11-fold more ... or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants). Peripheral blood of CD18-/- mutants contained 11-fold more ...
Other CD Antigens | ProSpec
CD11b Antibody (Monoclonal, M1/70.15)
Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; CD11b; CD11B (p170); cell surface glycoprotein MAC-1 ... CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). ... macrophage antigen alpha; macrophage antigen alpha polypeptide; Neutrophil adherence receptor; neutrophil adherence receptor ... CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, ...
Anti-Ratte (Rattus) CD11b Antikörper für Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Antigen Integrin alpha M (ITGAM) Antikörper Synonyme für dieses Antigen anzeigen * CD11b/CD18 ... Synonyms: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell ... CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor ...
Anti-Mouse (Murine) CD11b antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Antigen Integrin alpha M (ITGAM) Antibodies show synonyms for this antigen * CD11b/CD18 ... Synonyms: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell ... CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor ...
CD11b Antibody, eFluor® 450 (Monoclonal, M1/70)
CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). ... M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood ... CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, ... CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen ...
CD18 Antibody, anti-human | Hybridomas | MACS Antibodies | Products | Miltenyi Biotec | Suomi
Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic ... CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in ... Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90-95 kDa. It non- ... Alternative names of antigen. ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7. ...
CD11a/CD18 Antibody, anti-mouse, REAfinity™ - Recombinant antibodies - MACS Antibodies - Products - Miltenyi Biotec - Italia
... also known as lymphocyte function-associated antigen 1 (LFA-1). LFA-1 is a member of the integrin family and consists of two ... chains, a (CD11a) and b2 (CD18). It is expressed on T and B cells as well as on macrophages and neutrophils. LFA-1 plays an ... Clone REA 880 recognizes the CD11a/CD18 heterodimer, also known as lymphocyte function-associated antigen 1 (LFA-1). LFA-1 is a ... Clone REA 880 recognizes the CD11a/CD18 heterodimer, also known as lymphocyte function-associated antigen 1 (LFA-1). LFA-1 is a ...
Lymphocyte function-associated antigen 1 - Wikipedia
LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16. Leukocyte ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ... The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. ...
Cell culture medium - Genetix Limited
... a tumor associated antigen such as HER2, HER3 or HER4 receptor; antibodies against various protein antigens like CD proteins ... anti-CD18 or anti-CD11b antibodies); growth factors such as VEGF; superoxide dismutase; factor; anti-clotting factors such as ... blood group antigens; flk2/flt3 receptor; obesity (OB) receptor; insulin A-chain; insulin B-chain; interleukins (ILs), e.g., IL ... viral antigen such as, for example, a portion of the AIDS envelope, gp120; transport proteins; homing receptors; addressins; ...
CD11aAntibodyAntibodiesCD11cReceptorHeterodimerIntegrinsFunction-associated antigenLigandCytotoxic T-lymphocyte-associated antigReceptorsCD11b non-covalently associates with CD18GlycoproteinSurface antigenMacrophageDendritic CellsCD54ITGAMType I transmembrane proteinGeneNeutrophilAnti-CD18 mAbMoleculesCarcinoembryonic antigenBeta 2-integrinCD11 and CD18CD79aRecombinantSubunitsImmunolIntegrin CD11bDifferentiation AntigensNeutrophilsLeukocytesMoleculeAdherenceMonocytesPeripheralMembrane ProteinsPathwaysCell SurfaceEndothelial
CD11a24
- The four alpha subunits are: CD11a (αL) (all leukocytes), CD11b (αM) (granulocytes, monocytes, some macrophages), CD11c (αX) (granulocytes, monocytes, dendritic antigen presenting cells), CD11d (αD) (CD8 T-cell subpopulation including large granular lymphocytes, macrophages and gamma-delta T cells in splenic red pulp). (beckman.com)
- CD18 non-covalently associates with CD11a, CD11b or CD11c. (biolegend.com)
- The most predominant beta 2-integrin lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2), expressed on all leukocytes, is essential for many adhesive functions of the immune system. (biomedcentral.com)
- This study reports the sequencing of the wild boar beta 2-integrin CD11a and CD18 cDNAs. (biomedcentral.com)
- Predicted CD11a and CD18 subunits share all the main structural characteristics of their mammalian homologues, with a larger interspecies conservation for the CD18 than the CD11a. (biomedcentral.com)
- Besides these strong overall similarities, wild boar and domestic pig LFA-1 differ by 2 (CD18) and 1 or 3 (CD11a) substitutions, of which one is located in the crucial I-domain (CD11a, E168D). (biomedcentral.com)
- CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). (novusbio.com)
- Clone REA 880 recognizes the CD11a/CD18 heterodimer, also known as lymphocyte function-associated antigen 1 (LFA-1). (miltenyibiotec.com)
- LFA-1 is a member of the integrin family and consists of two chains, a (CD11a) and b2 (CD18). (miltenyibiotec.com)
- CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with the integrin α subunits: CD11a, CD11b and CD11c (αL, αM and αX, respectively). (beckman.com)
- Shang XZ, Issekutz AC: Contribution of CD11a/CD18, CD11b/CD18, ICAM-1 (CD54) and -2 (CD102) to human monocyte migration through endothelium and connective tissue fibroblast barriers. (exbio.cz)
- ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. (prospecbio.com)
- CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. (fishersci.com)
- Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)
- CD11a/CD18) is one of the integrins (β2 integrins) exclusively expressed on leukocytes, and its counterligands are the intercellular adhesion molecules 1, 2, and 3 (ICAM-1, -2, and -3) ( 13 , 35 , 59 ). (asm.org)
- Lymphocyte function-associated antigen 1 is a heterodimer integrin CD11a (integrin alpha L, p189) and CD18 (integrin beta-2). (brainscape.com)
- 2 In addition, fluvastatin inhibits the expression of lymphocyte function-associated antigen (CD11a/CD18) and ICAM-1 on human monocytic cell lines. (ahajournals.org)
- The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). (fishersci.com)
- Lymphocyte and monocyte ligands, L-selectin, sialated glycoproteins, lymphocyte function-associated antigen 1 (LFA-1) (CD11a, CD18), and Mac1 (CD11b, CD18) bind to the EC rec and modulate the migration of these cells. (medscape.com)
- CD11a/CD18) in cytokine-triggered firm leukocyte adhesion to arterial endothelium in vivo. (lu.se)
- CD11a/CD18) when migrating in response to chemoattractants either across the vasculature into lymph nodes or across stimulated vessels associated with infected tissue. (rupress.org)
- Interactions between cytotoxic lymphocytes and their targets require the T cell antigen receptor (TCR) and the integrin lymphocyte function-associated molecule-1 (LFA-1, CD11a/CD18). (sciencemag.org)
- CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1). (peprotech.com)
- The intercellular adhesion molecules ICAM-1, 2 and 3 are, like VCAM-1, members of the immunoglobulin superfamily (IgSF), but they are recognized by an I domain-containing integrin, lymphocyte-function-associated antigen 1 (LFA-1, or CD11a/CD18). (rcsb.org)
Antibody16
- i) interaction between lymphocytes, (ii) interaction between T-cells and antigen presenting cells, (iii) adhesion of naïve lymphocytes to post-capillary high endothelial venules of secondary lymphoid tissues, (iv) adhesion of leukocytes to activated endothelium at sites of inflammation for extravasation, (v) control of cell differentiation and proliferation, and (vi) antibody-dependent killing by natural killer cells and granulocytes. (biomedcentral.com)
- There are currently no images for Integrin beta 2/CD18 Antibody (NBP1-44612). (novusbio.com)
- In human umbilical vein endothelial cells infected with cytomegalovirus (CMV), an activation antigen recognized by monoclonal antibody (mAb) ENA1 appeared. (nih.gov)
- This antibody recognizes the antigen presenting on the cell surface membrane of tissue macrophages. (osu.edu)
- Phospho-CD18 (Ser756/Thr758/759) Antibody Shipping Temperature: HOT Storage Temperature: -20C. (bio-medicine.org)
- Amplification of Human B Cell Activation by a Monoclonal Antibody to the B Cell-Specific Antigen CD22, Bp 130/140," J. Immunol. (freepatentsonline.com)
- The antibody MEM-148 recognizes an extracellular epitope on CD18 which is essentially inaccessible in intact integrin molecules on resting leukocytes, but is exposed on high-affinity state of LFA-1 or on unassociated CD18. (exbio.cz)
- Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD18 (MEM-48) Alexa Fluor® 700 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
- Separation of human lymphocytes (red-filled) from human CD18 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD18 (MEM-48) Alexa Fluor® 700 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
- Monoclonal antibody to CD18, the beta-chain of LFA-1, did not induce this phenotype. (biomedsearch.com)
- antibody responses to polysaccharide antigens are decreased and antibody responses to protein antigens are slightly reduced. (medscape.com)
- Altieri DC, Edgington T (1988) A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD11b/CD18 (Mac-1). (springer.com)
- Applications Tested: This 118/A5 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval. (fishersci.com)
- Based on expression of CD138 and B220, we reveal a unique and major subtype of antigen-specific memory B cells (B220 − CD138 − ) that are distinct from antibody-secreting B cells (B220 +/ −CD138 + ) and B220 + CD138 − memory B cells. (rupress.org)
- The pattern of cellular differentiation after transfer indicates that B220 − memory B cells act as stable self-replenishing intermediates that arise from B220 + memory B cells and produce antibody-secreting cells on rechallenge with antigen. (rupress.org)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
Antibodies10
- In contrast, anti-very late antigen (VLA)-5 mAb antibodies significantly reduced Mn(2+)-mediated PMN adherence to fibronectin, but not to laminin or fibrinogen, demonstrating that VLA-5-mediated PMN adherence to fibronectin, but not to fibrinogen or laminin. (jimmunol.org)
- These data are consistent with expectations based on studies using blocking antibodies to inhibit CD11/CD18 complexes, and on observations of humans lacking CD11/CD18 complexes. (nih.gov)
- The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)
- However, variation of this coat can lead to antibodies being unable to recognize and eliminate the antigen. (wikipedia.org)
- CTVT samples were incubated with biotinylated antibodies to specific membrane and cytoplasmic antigens (anti-lysozyme, anti-macrophage, anti-vimentin, anti-CD18, monoclonal anti-CD117, monoclonal anti-CD3, polyclonal anti-CD117, polyclonal CD3 and anti-CD79a), followed by the avidin-biotin-peroxidase complex technique. (scielo.br)
- There was no immunoreactivity to anti-lysozyme, anti-macrophage, anti-CD18, monoclonal anti-CD117, monoclonal anti-CD3 and anti-CD79a antibodies. (scielo.br)
- Anti-interleukin (IL)-1α/β and anti-tumor necrosis factor-α antibodies, or anti-lymphocyte function-associated antigen-1 and very late antigen-4 antibodies, had little or no inhibitory effects on MCP-1 secretion by cocultures. (ahajournals.org)
- Precise cell identification can be achieved by the application of monoclonal antibodies (mAb) specific for leukocyte antigens to isolated cells, cell smears and tissue sections. (vin.com)
- Argenbright LW, Letts LG, Rothlein R (1991) Monoclonal antibodies to the leukocyte membrane CD18 glycoprotein complex and to intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits. (springer.com)
- It involved β2 integrins and Fcγ receptor, because it was prevented by anti-CD18 antibodies and was not observed with anti-PR3 F(ab′) 2 . (asnjournals.org)
CD11c2
- The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. (fishersci.com)
- CD11c/CD18 signals very late antigen-4 activation to initiate foamy monocyte recruitment during the onset of hypercholesterolemia. (springermedizin.de)
Receptor10
- The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). (thermofisher.com)
- On the other hand, trisomy 4 was found in three cases (3.2%) and these cells showed low expressions of CD19 ( P =0.06) and IL-7 receptor ( P =0.05), and high expressions of CD33 ( P =0.13), CD18 ( P =0.03), and CD56 ( P =0.03) when compared to t(8;21) AML without additional karyotypes. (nature.com)
- Additional derivation of a round cell origin can be made through the use of smooth muscle actin, desmin, Factor VIII-related antigen and glial fibrillary acidic protein (for sarcomas) or staining for specific proteins such as various hormones and hormones receptors such as estrogen receptor. (veterinarypracticenews.com)
- Antigen standard for integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
- In the case of lymphoid proliferation, assessment of B or T cell antigen receptor rearrangement by polymerase chain reaction (PCR) provides valuable information pertaining to antigen receptor diversity in the lesion. (vin.com)
- Similarly, B cells are identified by demonstration of the components of the B cell antigen receptor complex (specifically CD79a). (vin.com)
- Altieri DC, Wiltse WL, Edgington TS (1990b) Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18. (springer.com)
- Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8 + T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. (aacrjournals.org)
- MCp concentrations were not altered in the tissues of mice deficient in the alphaE integrin (CD103), the beta2 integrin (CD18), or the recombination activating gene (RAG)-2 gene either alone or in combination with the interleukin (IL)-receptor common gamma chain. (nih.gov)
- Clonality of the B-cell population could not be demonstrated using PCR testing for antigen receptor gene rearrangement. (tennessee.edu)
Heterodimer3
- The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the α M (CD11b) and β 2 (CD18) subunits, is critical for leukocyte adhesion and migration and for immune functions. (sciencemag.org)
- CD11, along with CD18, form a heterodimer adhesion molecule. (fishersci.com)
- Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections. (acris-antibodies.com)
Integrins7
- The beta2 integrins (CD11/CD18) are the major adhesion molecule family of leukocytes. (beckman.com)
- These receptors are essential for an effective immune system as observed in repeated infections associated with the lymphocyte adhesion deficiency (LAD) type I syndrome, a disease due to mutations in the β 2 (CD18) subunit gene leading to the lack of functional β 2 integrins on the membrane surface of leukocytes [ 12 - 14 ]. (biomedcentral.com)
- CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. (miltenyibiotec.com)
- Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. (miltenyibiotec.com)
- Drbal K, Angelisova P, Cerny J, Hilgert I, Horejsi V: A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins. (exbio.cz)
- Integrins, specifically leukocyte function associated antigen LFA-1, are cell surface molecules which play a role in T-cell activation. (knowcancer.com)
- 10. Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V: A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. (acris-antibodies.com)
Function-associated antigen7
- Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. (wikipedia.org)
- Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells. (biomedsearch.com)
- Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic aggregation in T cells and to induce cytoskeletal changes in T lymphoma cells. (biomedsearch.com)
- To identify the intracellular signals which increase the adhesiveness of leukocyte function-associated antigen 1 (LFA-1), we established an assay system for activation-dependent adhesion through LFA-1/intercellular adhesion molecule 1 ICAM-1 using mouse lymphoid cells reconstituted with human LFA-1 and then introduced constitutively active forms of signaling molecules. (asm.org)
- We have investigated the distribution, activity, and cytoskeletal linkage of the integrin lymphocyte function associated antigen-1 (LFA-1) on human T lymphocytes migrating on endothelial cells and on ligand intercellular adhesion molecule-1 (ICAM-1). (rupress.org)
- Our data demonstrate that CD40 triggering on XG2 cells induced a myeloma cell growth arrest mediated by lymphocyte function-associated antigen 1 and intercellular adhesion molecule 2 interactions. (aacrjournals.org)
- The lymphocyte function-associated antigen 1 (LFA-1) is a member of the beta2-integrin family and plays a pivotal role for T cell activation and leukocyte trafficking under inflammatory conditions. (mdpi.com)
Ligand7
- It is only expressed and present on T cells for a short interval occurring after TCR engagement, and has a single identified ligand, 4-1BBL, found on antigen presenting cells ( 4 ). (frontiersin.org)
- The engagement of 4-1BB by its ligand or agonistic mAbs provides substantial boosts to the T cell response ( 4 ), which prompted the incorporation of 4-1BB intracellular signaling domain into TCR-like chimeric antigen receptors (CARs) and ultimately greatly improved their functionality ( 5 ). (frontiersin.org)
- In turn this activation antigen ELAM-1 binds with its putative ligand present on the PMN membrane. (nih.gov)
- A CD Antigen that contains a conserved I domain which is involved in ligand binding. (online-medical-dictionary.org)
- LFA-1 is not constitutively adhesive, and upregulation of the adhesive activity (avidity) of LFA-1 by external stimuli such as cytokines, chemokines, or antigens is a prerequisite for ligand binding ( 34 , 58 ). (asm.org)
- We also investigated 4-F-GlcNAc efficacy on lymphocyte E-selectin ligand expression in LNs draining antigen-sensitized skin and on other immunological processes requisite for CHS responses. (jci.org)
- These data indicate that 4-F-GlcNAc prevents CHS by inhibiting selectin ligand activity and the capacity of effector T cells to enter antigen-challenged skin without affecting the afferent phase of CHS. (jci.org)
Cytotoxic T-lymphocyte-associated antig2
- The antagonistic mAbs used in immune checkpoint blockade are able to block T cell-inhibitory signaling from receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death-1 (PD-1), and have been successfully used in the treatment of several types of cancers ( 1 ). (frontiersin.org)
- The engagement of the B7 family of molecules on APCs with CD28 and CD152 (cytotoxic T lymphocyte-associated antigen 4 [CTLA-4]) receptors on T cells delivers costimulatory signal(s) important in T cell activation. (rupress.org)
Receptors2
- Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
- This chapter discusses selected scavenger and lectinlike antigen-presenting cell (APC) receptors in relation to innate immunity to illustrate principles and provide questions for further study. (asmscience.org)
CD11b non-covalently associates with CD182
- CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. (thermofisher.com)
- CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. (biolegend.com)
Glycoprotein3
- The results obtained after incubation of PMN with mAb IB4 (against CD18) suggest that the adhesion of PMN to uninfected endothelial cells is CD18 glycoprotein dependent, and virus infection up-regulates this glycoprotein-dependent mechanism. (nih.gov)
- The virus-induced PMN adhesion occurs also through a CD18 glycoprotein-dependent mechanism. (nih.gov)
- This is achieved through the switching of its variant surface glycoprotein or VSG, a substance that coats the entire antigen. (wikipedia.org)
Surface antigen2
- This recognises the human CD18 cell surface antigen, the integrin beta2 subunit. (novusbio.com)
- mAb ENA1 reacts with an inducible endothelial surface antigen which has characteristics similar to those of ELAM-1. (nih.gov)
Macrophage1
- When combined with CD18 the two subunits form Macrophage-1 Antigen . (online-medical-dictionary.org)
Dendritic Cells5
- CD18 is expressed by all leukocytes (including histiocytes - macrophages, Langerhan's cells and dendritic cells) but no platelets. (beckman.com)
- Dendritic cells are the most potent antigen presenting cells. (vin.com)
- In this phase I study, we administered one or two cycles of four triweekly s.c./intradermal injections of ex vivo generated dendritic cells modified with a recombinant fowlpox vector encoding carcinoembryonic antigen (CEA) and a triad of costimulatory molecules [rF-CEA(6D)-TRICOM]. (aacrjournals.org)
- Because of the crucial role of dendritic cells in adaptive immunity and their potent activity in animal tumor models, numerous pilot studies have evaluated immunotherapy with dendritic cells loaded with antigen in the form of peptide, protein, DNA, mRNA, tumor lysates, tumor fusions, and viral vectors ( 1 ). (aacrjournals.org)
- To overcome these limitations, we have been studying strategies for genetic modification of dendritic cells with viral vectors encoding full length tumor antigens and costimulatory molecules. (aacrjournals.org)
CD542
- Expression of CD40, CD54, and major histocompatibility complex (MHC) class II HLA-DR antigens by lesional keratinocytes was markedly reduced in serial biopsy specimens. (rupress.org)
- This is present on both T and B cells and binds to ICAM-1 (CD54) on antigen presenting cells. (brainscape.com)
ITGAM1
- CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). (thermofisher.com)
Type I transmembrane protein3
- CD18 is a 90-95 kD type I transmembrane protein also known as integrin β 2 subunit, LFA-1 β subunit, and β 2 integrin. (biolegend.com)
- CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes. (novusbio.com)
- Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90-95 kDa. (miltenyibiotec.com)
Gene1
- Defects in the CD18 gene results in leukocyte adhesion deficiency. (osu.edu)
Neutrophil8
- Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to fibronectin. (jimmunol.org)
- Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. (nih.gov)
- To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants). (nih.gov)
- During Streptococcus pneumoniae pneumonia, neutrophil emigration in CD18-/- mutants was not reduced. (nih.gov)
- Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18-/- mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis. (nih.gov)
- Dermal neutrophil emigration in WT and CD18−/− mice 6 h after topical application of 2% croton oil. (nih.gov)
- Gao JX, Issekutz AC: Mac-1 (CD11b/CD18) is the predominant beta 2 (CD18) integrin mediating human neutrophil migration through synovial and dermal fibroblast barriers. (exbio.cz)
- In conclusion, this study describes an amplifying loop in polymorphonuclear neutrophil activation process, whereby ANCA are involved in the membrane expression of their own antigen during cell adhesion. (asnjournals.org)
Anti-CD18 mAb2
- Anti-CD18 mAb almost completely blocked adherence to laminin, partly blocked adherence to fibrinogen, but did not inhibit adhesion to fibronectin at all. (jimmunol.org)
- Triggering CD40 induced an homotypic aggregation of XG2 cells, and the inhibition of proliferation was totally prevented by a blocking anti-CD18 mAb. (aacrjournals.org)
Molecules4
- Hence, DC in humans and dogs are best defined by their abundant expression of molecules essential to their function as antigen presenting cells. (vin.com)
- Chatila TA, Geha RS, Arnaout MA (1989) Constitutive and stimulus-induced phosphorylation of CDU/ CD18 leukocyte adhesion molecules. (springer.com)
- To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen. (aacrjournals.org)
- Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. (springermedizin.de)
Carcinoembryonic antigen2
- Here, we generate a bispecific 4-1BB-agonistic trimerbody targeting the carcinoembryonic antigen (CEA) that is highly expressed in cancers of diverse origins. (frontiersin.org)
- Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because it is widely expressed in gastrointestinal, lung, breast, and other malignancies. (aacrjournals.org)
Beta 2-integrin1
- The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
CD11 and CD182
- LAD1 is caused by low expression of CD11 and CD18. (wikipedia.org)
- LFA-1 is made up of two subunits, known as CD11 and CD18. (knowcancer.com)
CD79a1
- as are markers for cluster differentiation (CD) antigens such as CD79a (for B cells) and CD3 (for T cells). (veterinarypracticenews.com)
Recombinant1
- These cells constitutively expressed high levels of major histocompatibility complex (MHC) class II antigens but unlike EOC-20 (CRL-2469) expression was not upregulated by recombinant murine interferon-gamma. (atcc.org)
Subunits1
- CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with one of four α subunits. (beckman.com)
Immunol3
- Structural Characterization of the Human B Lymphocyte-Restricted Differentiation Antigen CD22," J. Immunol. (freepatentsonline.com)
- HD39 (B3), A B Lineage-Restricted Antigen Whose Cell Surface Expression is Limited to Resting and Activated Human B Lymphocytes," J. Immunol. (freepatentsonline.com)
- Role of the CD22 Human B Cell Antigen in B Cell Triggering by Anti-Immunoglobulin," J. Immunol. (freepatentsonline.com)
Integrin CD11b2
- ADH-503 is an allosteric agonist of integrin CD11b/CD18 (also known as Mac-1) with an EC50 value of 4 mM. (axonmedchem.com)
- These cells express both myeloid lineage differentiation antigen Gr-1 (Ly6G and Ly6C) and α M integrin CD11b, and in control mice represent ∼20% to 30% of normal bone marrow cells, 2% to 4% of all nucleated splenocytes, and are practically absent in lymph nodes. (aacrjournals.org)
Differentiation Antigens3
- The HB-6, CDw75, and CD76 Differentiation Antigens are Unique Cell-Surface Carbohydrate Determinants Generated by the .beta. (freepatentsonline.com)
- White Cell Differentiation Antigens" McMichael, A. J., Oxford University Press. (freepatentsonline.com)
- Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced b. (biomedsearch.com)
Neutrophils7
- TDM-induced Mincle signaling on neutrophils increased cell adherence by enhancing F-actin polymerization and CD11b/CD18 surface expression. (nih.gov)
- Moreover, coactivation of the Mincle and TLR2 pathways by TDM and Pam3CSK4 treatment synergistically induced CD11b/CD18 surface expression, reactive oxygen species, and TNFα production by neutrophils. (nih.gov)
- Peripheral blood of CD18-/- mutants contained 11-fold more neutrophils than did blood of wild-type (WT) mice. (nih.gov)
- During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18-/- mutants than in WT mice. (nih.gov)
- The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18-/- mutants, but rather was greater than the WT values (240 +/- 30 and 220 +/- 30% WT, respectively). (nih.gov)
- Emigrated neutrophils were quantitated morphometrically and expressed as mean ± SEM standardized volume fractions for WT (closed bars) or CD18−/− (open bars) mice. (nih.gov)
- In contrast, there was no increase in emigrated neutrophils in the dermis of CD18−/− mutant mice after 6 h of croton oil dermatitis (Fig. 2). (nih.gov)
Leukocytes3
- CD18 is expressed on all leukocytes. (biolegend.com)
- and the beta subunit, unique to leukocytes, is beta-2 or CD18. (wikipedia.org)
- CD18 is expressed by most leukocytes. (osu.edu)
Molecule1
- Here, we used an alternative strategy of inhibiting leukocyte recruitment by activating CD11b/CD18 with small-molecule agonists, which we term leukadherins. (sciencemag.org)
Adherence2
- Activation of PMN with phorbol ester or C5a stimulated VLA-5-mediated adhesion to fibronectin, but the contribution of VLA-5 to the forces mediating adherence could only be detected when CD18 function was either blocked with mAb, or when CD18 was congenitally absent. (jimmunol.org)
- Cytomegalovirus induced PMN adherence in relation to an ELAM-1 antigen present on infected endothelial cell monolayers. (nih.gov)
Monocytes2
- M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. (thermofisher.com)
- 4,5 Lovastatin affects the β2 integrin family of proteins by preventing the formation of CD11b/CD18 heterodimers on monocytes. (ahajournals.org)
Peripheral1
- Flow cytometry analysis (surface staining) of CD18 in human peripheral blood with anti-CD18 (MEM-148) PE. (exbio.cz)
Membrane Proteins1
- Through the recombination of H. pylori's outer membrane proteins, immunoglobulins can no longer recognize these new structures and, therefore, cannot attack the antigen as part of the normal immune response. (wikipedia.org)
Pathways1
- Some antigens may even target pathways different than those the vaccine had originally intended to target. (wikipedia.org)
Cell Surface1
- The interaction with antigen-presenting cells is also a dynamic one in which the T cell crawls across the cell surface in an LFA-1-dependent manner, scanning for antigenic peptides. (rupress.org)
Endothelial2
- Factor VIII-realted antigen (vonWillebrand factor) is present in endothelial cells and in the cytoplasm of megakaryocytes. (osu.edu)
- These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues. (acris-antibodies.com)