Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antigens, CD147: A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.Tissue Inhibitor of Metalloproteinases: A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Goats: Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Bilirubin: A bile pigment that is a degradation product of HEME.Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Hyperbilirubinemia: A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Asteraceae: A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.Actinidia: A plant species of the family ACTINIDIACEAE, order Theales.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.Qi: The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)MinnesotaBiomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.MississippiAntigens, CD3: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).CD40 Ligand: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.Antigens, CD40: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Antigens, CD28: Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.CD4-CD8 Ratio: Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.Antigens, CD14: Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.Antigens, CD38: A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.Brain Stem Neoplasms: Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.Epitopes: Sites on an antigen that interact with specific antibodies.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Antigens, CD20: Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Meiosis: A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.Spermatids: Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Chromosome Pairing: The alignment of CHROMOSOMES at homologous sequences.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Sertoli Cells: Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.Acrosome: The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Spermatocytes: Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.

CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1/ICAM-1 pathway. (1/318)

CD147 is a 50 000-60 000 MW glycoprotein of the immunoglobulin superfamily broadly expressed on haemopoietic cell lines and peripheral blood cells. In the present study, six monoclonal antibodies (mAbs) directed against the CD147 protein were generated. The antigen defined by the generated CD147 mAbs is widely expressed on haemopoietic cell lines, peripheral blood cells and is a lymphocyte activation-associated cell surface molecule. The generated CD147 mAbs precipitated a broad protein band from U937 cells of 45 000-65 000 MW under reducing conditions. Functional analysis indicated that the CD147 mAbs markedly induced homotypic cell aggregation of U937 cells, but not K562 cells. The CD147 mAb-induced cell aggregation was inhibited by leucocyte function-antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) mAbs. However, the expression of LFA-1 and ICAM-1 molecules on U937 was not altered by CD147 mAb treatment. The U937 cell aggregation induced by CD147 mAb was also inhibited by ethylenediamine tetra-acetic acid (EDTA), sodium azide and when incubated at 4 degrees. We therefore propose that the binding of CD147 mAb to CD147 molecule, which mimics the natural ligand binding, may generate intracellular signals that activate LFA-1/ICAM-1 intercellular adhesion pathway.  (+info)

T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density. (2/318)

CD147 is a broadly expressed cell surface glycoprotein of the Ig superfamily whose expression is up-regulated upon T cell activation. In order to elucidate a possible role of CD147 in T cell biology, we established 15 specific mAb. Seven distinct epitopes were defined by the mAb panel. Most of the mAb bound only to phytohemagglutinin (PHA)-activated but not resting T cells. We demonstrate that this was not because of true expression of activation-dependent neoepitopes but rather due to bivalent binding of the relatively low-affinity mAb (affinity constant KA values between 2.25 x 10(8) and 7 x 10(9) M-1) to the more densely expressed and/or more clustered CD147 molecules on the activated T cells. In contrast, the mAb with higher affinity (KA > 7 x 10(9) M-1) could stably bind in a monovalent fashion even to the relatively low dense CD147 molecules on resting T cells. This model might more generally explain the nature of 'activation epitopes' described previously in other leukocyte surface molecules. Finally, we provide evidence that induction of ordered dimerization of CD147 by a mAb directed to a unique epitope results in strong inhibition of CD3-mediated T cell activation.  (+info)

Differential expression of novel abundant and highly regionalized mRNAs of the canine epididymis. (3/318)

Three novel gene products have been cloned by differential screening of a dog epididymis cDNA library as part of a global appraisal of specific gene expression in the epididymis. The predicted proteins were provisionally named CE8-CE10 (for canine epididymal gene products 8-10). Northern blot analyses and in situ transcript hybridization confirmed that the cDNAs were all derived from tissue-specific, moderately to highly abundant mRNAs of the epididymal epithelium, showing a distinct regionalized expression pattern within the epididymal duct. Their sequences predict (i) a novel 19 kDa member of the Ly-6-domain protein superfamily (CE8), (ii) an approximately 30 kDa protein with multiple membrane-spanning regions (CE9), and (iii) a novel approximately 13 kDa single whey acidic protein domain protein (CE10). Closely related, cross-hybridizing gene products were abundant in the epididymis of stallions and bulls, but not in rodents or men. Changes in mRNA frequency were observed that specifically correlated with a cryptorchid situation and with the age of the dogs. Gene products restricted to the caput epididymidis were affected by both conditions, while those with a wider regional distribution were not.  (+info)

Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium. (4/318)

OBJECTIVE: To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the synovial membrane of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS: Mouse monoclonal antibody against human EMMPRIN was applied according to an avidin-biotin-peroxidase complex method to reveal EMMPRIN expression. Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR) were performed to check for the presence of EMMPRIN protein and messenger RNA (mRNA). RESULTS: EMMPRIN immunoreactivity was more intense in RA than in OA synovial membrane (P < 0.01). EMMPRIN staining was more widespread in RA than in OA, especially in association with macrophage infiltrates. RT-PCR of synovial membrane samples disclosed the presence of EMMPRIN mRNA. Nucleotide sequencing of the PCR amplification products confirmed the identity of the amplified bands. Immunoblot analysis revealed 55-kd glycosylated EMMPRIN bands, which were particularly prominent in RA samples. CONCLUSION: The expression of EMMPRIN is upregulated in the rheumatoid synovial membrane. EMMPRIN can induce local production of at least MMPs 1, 2, and 3, and can thereby play a role in joint destruction in RA.  (+info)

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface. (5/318)

Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at the tumor cell surface. Complex formation was demonstrated by phage display, affinity chromatography, and immunocytochemistry. Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in modifying the tumor cell pericellular matrix to promote invasion.  (+info)

The expression and cellular localization of the sperm flagellar protein MC31/CE9 in the rat testis: possible posttranscriptional regulation during rat spermiogenesis. (6/318)

We isolated the MC31 cDNA clone coding the antigen specifically recognized by the monoclonal antibody mMC31, and found that MC31 was identical to rat CE9. Therefore, this molecule is called MC31/CE9. MC31/CE9, a member of the immunoglobulin superfamily molecules, was localized on the rat sperm flagellar plasma membrane. We analyzed the expression and cellular localization of MC31/CE9 mRNA and protein in the adult rat testis by use of Northern hybridization, in situ hybridization, and immunohistochemical analyses. In the course of spermatogenesis, MC31/CE9 mRNA first appeared in type B spermatogonia. The mRNA signal intensity increased progressively to pachytene spermatocytes and remained constantly at a considerable level throughout the subsequent phases of spermatocytes and round spermatids, and then decreased gradually from step-11 spermatids to disappear in step-15 spermatids. On the other hand, MC31/CE9 protein expression showed a bimodal pattern. Immunohistochemical analysis for the MC31/CE9 protein revealed its most intense immunoreactivity on the flagella of step-8 to step-19 elongated spermatids. The cytoplasmic immunoreactivity of the MC31/CE9 protein also appeared in preleptotene to early pachytene spermatocytes and elongated spermatids, with particularly intense immunoreactivity in the Golgi complexes of zygotene and early pachytene spermatocytes (stage XIII to III) as well as step-8 to step-13 spermatids. Between these two phases, the MC31/CE9 protein proved undetectable in the cytoplasm of any spermatogenic cells. Sertoli cells and Leydig cells were devoid of MC31/CE9 mRNA and its protein. Therefore, the production of MC31/CE9 is thought to be posttranscriptionally regulated during spermiogenesis.  (+info)

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia. (7/318)

Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion. Many biochemical and molecular markers of chondrocyte hypertrophy are absent from the lesion, or show reduced expression, but the cause of the disorder remains to be identified. As differentiation to the hypertrophic state is impaired in TD, we hypothesised that chondrocyte genes that are differentially expressed in the growth plate should show altered expression in TD. Using differential display, four genes, B-cadherin, EF2, HT7 and Ex-FABP were cloned from chondrocytes stimulated to differentiate to the hypertrophic stage in vitro, and their differential expression confirmed in vivo. Using semi-quantitative RT-PCR, the expression patterns of these genes were compared in chondrocytes from normal and TD growth plates. Surprisingly, none of these genes showed the pattern of expression that might be expected in TD lesion chondrocytes, and two of them, B-cadherin and Ex-FABP, were upregulated in the lesion. This indicates that the TD phenotype does not merely reflect the absence of hypertrophic marker genes, but may be influenced by more complex developmental mechanisms/defects than previously thought.  (+info)

Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. (8/318)

Basigin (Bsg) is a highly glycosylated transmembrane protein with two immunoglobulin (Ig)-like domains. A number of studies, including gene targeting, have demonstrated that Bsg plays pivotal roles in spermatogenesis, implantation, neural network formation and tumor progression. In the present study, to understand the mechanism of action of Bsg, we determined its expression status on the plasma membrane. Cotransfection of Bsg expression vectors with two different tags clarified that Bsg forms homo-oligomers in a cis-dependent manner on the plasma membrane. If the disulfide bond of the more N-terminally located Ig-like domain was destroyed by mutations, Bsg could not form oligomers. In contrast, the mutations of the C-terminal Ig-like domain or N-glycosylation sites did not affect the association. The association of mouse and human Bsgs, which exhibit high homology in the transmembrane and intracellular domains but low homology in the extracellular domain, was very weak as compared with that within the same species, suggesting the importance of the extracellular domain in the association. If the extracellular domain of the human Ret protein was replaced with the N-terminal Ig-like domain of Bsg, the resulting chimera protein was associated with intact wild-type Bsg, but not if the C-terminal Ig-like domain, instead of the N-terminal one, of Bsg was used. No oligomer formation took place between the intact wild-type Ret and Bsg proteins. In conclusion, these data indicate that the N-terminal Ig-like domain is necessary and sufficient for oligomer formation by Bsg on the plasma membrane.  (+info)

*Gavilimomab

It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy. It was ...

*List of MeSH codes (D23)

... antigens, cd147 MeSH D23.050.301.264.035.264 --- antigens, cd164 MeSH D23.050.301.264.035.270 --- antigens, thy-1 MeSH D23.050. ... antigens, cd147 MeSH D23.101.100.110.264 --- antigens, cd164 MeSH D23.101.100.110.270 --- antigens, thy-1 MeSH D23.101.100.110. ... antigens, cd24 MeSH D23.050.285.025 --- antigens, cd30 MeSH D23.050.285.040 --- antigens, cd147 MeSH D23.050.285.050 --- ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ...

*Mannose receptor

The mannose receptor may also play a role in antigen uptake and presentation by immature dendritic cells in the adaptive immune ... MRC2/Endo180 interacts with Basigin/CD147 via its fourth C-type lectin domain to form a molecular epithelial-mesenchymal ... There is also potential for use of the mannose receptor as a target for improved macrophage activation and antigen presentation ... The cleaved, soluble receptor binds to circulating antigens and directs them to effector cells in lymphoid organs via its ...

*Basigin

1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... Wang WJ, Li QQ, Xu JD, Cao XX, Li HX, Tang F, Chen Q, Yang JM, Xu ZD, Liu XP (2008). "Interaction between CD147 and P- ... 2001). "CD147 is a signaling receptor for cyclophilin B". Biochem. Biophys. Res. Commun. 288 (4): 786-8. doi:10.1006/bbrc. ... Yurchenko V, O'Connor M, Dai W, Guo H, Toole B, Sherry B, Bukrinsky M (2001). "CD147 is a signaling receptor for cyclophilin B ...

*Sandra Saouaf

1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of Biological Chemistry. ... Iacono, Kathryn T.; Brown, Amy L.; Greene, Mark I.; Saouaf, Sandra J. (December 2007). "CD147 Immunoglobulin Superfamily ... "Temporal Differences in the Activation of Three Classes of Non-Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen ...

*Chromosome 19 (human)

The enzyme it encodes catalyzes the production of H antigen. MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus ... Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... 5: The ABO blood group". Blood Groups and Red Cell Antigens. Bethesda MD: National Center for Biotechnology Information. ... Gene map locus 19q13.32 PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32 DMPK: Dystrophia myotonica-protein kinase. ...

*Ubiquitin C

Wang WJ, Li QQ, Xu JD, Cao XX, Li HX, Tang F, Chen Q, Yang JM, Xu ZD, Liu XP (2008). "Interaction between CD147 and P- ... "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proceedings of the ... "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled ...
TY - JOUR. T1 - Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition of bim. AU - Yang, Jin Ming. AU - ONeill, Peter. AU - Jin, Wei. AU - Foty, Ramsey. AU - Medina, Daniel J.. AU - Xu, Zude. AU - Lomas, Mehnaaz. AU - Arndt, Greg M.. AU - Tang, Yi. AU - Nakada, Marian. AU - Yan, Li. AU - Hait, William N.. PY - 2006/4/7. Y1 - 2006/4/7. N2 - Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival of malignant cells and confers resistance to some chemotherapeutic drugs. However, the molecular mechanisms underlying the actions of EMMPRIN are not fully understood. In this study we sought to determine whether EMMPRIN contributes to the malignant phenotype of breast cancer by inhibiting anoikis, a form of apoptosis induced by loss or alteration of ...
Introduction: We have shown that interleukin (IL)-18 plays a role in myocardial injury and remodeling via induction of matrix metalloproteinases (MMPs) and other proinflammatory cytokines. Since the matricellular protein EMMPRIN (basigin/CD147) is a potent inducer of MMPs, we investigated if IL-18 and EMMPRIN expression is cross-regulated, and whether IL-18-induced MMP9 expression is EMMPRIN-dependent.. Methods and results: IL-18 potently induced EMMPRIN expression and secretion in adult mouse cardiomyocytes (ACM; inhibited by IL-18 neutralizing antibodies and IL-18BP-Fc). IL-18 stimulated both Sp1 and NF-κB activations in ACM. In neonatal mouse cardiomyocytes (NMCM), IL-18 stimulated EMMPRIN promoter activity was inhibited by mithramycin and over-expressed mutant Sp1, but not by dominant negative (dn) p65, dnIκB-α, or kdIKKβ. Mutation of the Sp1 binding sites blunted IL-18-stimulated EMMPRIN promoter activity. Transduction with adenoviral dominant negative constructs showed that IL-18 ...
CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function ...
(2010) Mishra et al. Reproductive Biology and Endocrinology. Background: Extracellular matrix metalloproteinase inducer (EMMPRIN) regulates several biological functions involving the modulation of cell behaviors via cell-cell and cell-matrix interactions. According to its diverse functions, we hy...
In the current study, we observed that pelvic lymph node metastases, which represent the tumor invasion and metastatic capability, were significantly associated with EMMPRIN overexpression. These results suggest that EMMPRIN expression in cervical cancer is associated with tumor invasion and metastasis. Our results are consistent with the previous reports of the roles of EMMPRIN in tumor progression (14), including gliomas (15), hepatoma (16), squamous cell carcinoma (17), and melanoma (18, 19). Furthermore, EMMPRIN was shown to be the most frequently expressed protein in primary tumors and in micrometastatic cells (20), and EMMPRIN score was significantly correlated with nodal stage (14), suggesting a central role in tumor progression and early metastasis. To our knowledge, this is the first study that investigates the expression of EMMPRIN and its clinical significance in radiotherapy outcome in cervical carcinoma. Interpretation of the results is aided by the homogeneous radiotherapy before ...
Polyclonal antibody for 575 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. 575 information: Molecular Weight: 42200 MW; Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Melanosome
Goat Polyclonal Anti-EMMPRIN/CD147 Antibody [Unconjugated]. Validated: WB, Simple Western, IHC. Tested Reactivity: Human. 100% Guaranteed.
Among other proteinases such as serine, cysteine, and aspartate proteinases, matrix MMPs have been shown to be essential for degradation of articular matrix as they not only cleave extracellular matrix components10 but also cleave each other, resulting in a domino effect of MMP propeptide and MMP activation.10 This is further supported by recently discovered extracellular MMP inducers that are closely associated with MMP-1 and MMP-3 synthesis in RA-SF.11 In total, about 20 members of the growing family of matrix MMPs are currently known (MMPs 1-3, 7-17, 19-21, 23, and 24), of which some belong to membrane-type (MT) MMPs-for example, MT1-MMP (MMP-14) and MT3-MMP (MMP-16) and to the MMP subfamily of aggrecanases.2. Numerous researchers have provided a large body of data showing that MMP-1 and MMP-3 are most important for joint destruction in RA.10 The present study underlines this hypothesis by associating MMP-1 and MMP-3 expression directly with a functional parameter-that is, the number of cells ...
H-ras transformed human bronchial epithelial cells (TBE-1) secrete a single major extracellular matrix metalloprotease which is not found in the normal parental cells. The enzyme is secreted in a latent form which can be activated to catalyze the cleavage of the basement membrane macromolecule type IV collagen. The substrates in their order of preference are: gelatin, type IV collagen, type V collagen, fibronectin, and type VII collagen; but the enzyme does not cleave the interstitial collagens or laminin. This protease is identical to gelatinase isolated from normal human skin explants, normal human skin fibroblasts, and SV40-transformed human lung fibroblasts. Based on this ability to initiate the degradation of type IV collagen in a pepsin-resistant portion of the molecule, it will be referred to as type IV collagenase. This enzyme is most likely the human analog of type IV collagenase detected in several rodent tumors. Type IV collagenase consists of three domains. Type IV collagenase ...
Photoreceptor nuclei were visualized with an antibody against elav, a neuron-specific nuclear protein. Normally, photoreceptor nuclei lie in tight rows across the eye (e.g. Fig. 6C), so that any mislocalization is readily detected. The nuclei of the R1-R6 photoreceptors lie in the apical region of the retina (Fig. 6C). The nuclei of the R7 photoreceptors are just proximal to those of R1-R6 and the R8 nuclei lie near the basement membrane of the retina (Fig. 6C).. Photoreceptor nuclei of mosaic flies mutant in the eye for the hypomorphic P1096 allele, which encodes a nuclear β-gal, were visualized with anti-β-gal (Fig. 5A). Most nuclei were properly located, although a few nuclei were misplaced (Fig. 6A). We saw similar results for these mosaics with anti-elav (not shown). In mosaics that are mutant in the eye for the bsgδ265 excision allele, elav immunolabeling revealed that 16-50% of photoreceptor nuclei were mislocalized (Fig. 6B). Nuclei were counted as misplaced only if they were ...
Shop Basigin ELISA Kit, Recombinant Protein and Basigin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The expression of EMMPRIN and its role in regulating stromal MMP expression have been extensively studied in various cancer types (2, 5-11, 18-20). The signaling events downstream of EMMPRIN-mediated tumor-host interactions that result in stimulation of MMP production are not yet fully established. The p38 MAPK has been implicated in inducing MMP-1 production (21); similarly, signaling through 5-lipooxygenase and phospholipase A2 may contribute to MMP-2 production (22). Recently, EMMPRIN has been shown to also participate in other activities during cancer progression not directly related to its function as a MMP stimulator (1). For example, EMMPRIN has been shown to potentiate tumor cell anchorage-independent growth (23), a phenomenon that is characteristic of malignant cancer cells, and may be related to multidrug resistance in cancer cells (24). These effects of EMMPRIN were shown to depend on stimulation of production of hyaluronan, a pericellular polysaccharide (23, 24), and cell survival ...
EMMPRIN down-regulation by scFv-M6-1B9 intrabody affecting decline of CEA level. Caco-2 cells transduced for 7 days and 10 days were collected as the supernatan
Mouse CD147 / EMMPRIN / Basigin derived in Human Cells. The whole cell lysate is provided in 1X Sample Buffer.Browse all transfected cell lysate positive controls
Can our products be used on different species? The simple answer is yes. BSG offers distinct and diverse separations tools that work with virtually all species. Read to learn more.
Farm leaders in Northern Ireland are pushing government officials to apply for a change in BSE status in a bid to increase beef prices. The Ulster Farmers
TY - JOUR. T1 - Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention. AU - Gwinn, William M.. AU - Damsker, Jesse M.. AU - Falahati, Rustom. AU - Okwumabua, Ifeanyi. AU - Kelly-Welch, Ann. AU - Keegan, Achsah D.. AU - Vanpouille, Christophe. AU - Lee, James J.. AU - Dent, Lindsay A.. AU - Leitenberg, David. AU - Bukrinsky, Michael I.. AU - Constant, Stephanie L.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - Extracellular cyclophilins have been well described as chemotactic factors for various leukocyte subsets. This chemotactic capacity is dependent upon interaction of cyclophilins with the cell surface signaling receptor CD147. Elevated levels of extracellular cyclophilins have been documented in several inflammatory diseases. We propose that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses. In this study, we examined whether extracellular ...
Blog on BSG elisa kit product: The Human BSG bsg (Catalog #MBS701560) is an ELISA Kit and is intended for research purposes only. The pr...
Mouse monoclonal antibody raised against recombinant BSG. Recombinant protein corresponding to human BSG. (MAB3633) - Products - Abnova
This event has been computationally inferred from an event that has been demonstrated in another species.. The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.. More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.. ...
Check the ski weather daily for Raleigh, NC from AccuWeather.com. Our ski weather forecasts are just one piece of travel weather available here.
The cell-surface glycoprotein basigin - also known as EMMPRIN - enhances growth and invasiveness of human metastatic tumours by stimulating secretion of matrix metalloproteinases (MMPs), which remodel the extracellular matrix. Now, however, Kathryn Curtin and colleagues report that basigin can also have dramatic effects on internal cell architecture (see p. 2649-2660). They show that the Drosophila homologue, D-basigin, promotes integrin-dependent cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. In vivo, loss of D-basigin in photoreceptors leads to misplaced nuclei and other structural changes that suggest disruption of the cytoskeleton; these changes can be rescued by fly or mouse basigin. The authors also report that D-basigin colocalizes with integrins in cultured insect cells and in the fly visual system, and partly colocalizes with actin in cultured insect cells, possibly indirectly through its interaction with integrins. Most importantly, D-basigin interacts ...
Here is the best resource for homework help with BSG 502 : Managerial Economics at Urbana. Find BSG502 study guides, notes, and practice tests from Urbana.
ExiSpin™ has the functions of a vortexer as well as a microcentrifuge and will significantly save your time in the lab. ExiSpin™ comes complete with rotor for 4 x 8-strip tubes and 12 x 1.5/2.0 ml tubes. Use it for Minipreps, to resuspend oligos, set up your PCR reaction, or any task that requires vortexing in micro test tube or 0.2 ml PCR tubes ...
TY - JOUR. T1 - Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma. AU - Hasegawa, Kazuaki. AU - Okui, Tatsuo. AU - Shimo, Tsuyoshi. AU - Ibaragi, Soichiro. AU - Kawai, Hotaka. AU - Ryumon, Shoji. AU - Kishimoto, Koji. AU - Okusya, Yuka. AU - Monsur Hassan, Nur Mohammad. AU - Sasaki, Akira. PY - 2018/10/25. Y1 - 2018/10/25. N2 - Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically, as it can invade facial bones and cause bone pain that is undertreated and poorly understood. Here we studied HNSCC bone pain (HNSCC-BP) in an intratibial mouse xenograft model that uses a human HNSCC cell line (SAS cells). These mice develop HNSCC-BP associated with an upregulation of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in the dorsal root ganglia (DRGs) of sensory nerve cell bodies. Our experiments demonstrated that the inhibition of monocarboxylate transporter 4 (MCT4) by short ...
Paper III. Lauritzen, F., Heuser, K., de Lanerolle, N.C., Lee, T-S.W., Spencer, D.D., Kim, J.H., Eid, T., Bergersen, L.H. (2012) Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. This is the pre-peer reviewed version of the article, which has been published in final form at: Glia 60(7), 1172-1181, July 2012. The published version of this paper is available at: https://doi.org/10.1002/glia.22344 ...
SWISS-MODEL Repository entry for C4ZUK7 (KEFG_ECOBW), Glutathione-regulated potassium-efflux system ancillary protein KefG. Escherichia coli (strain K12 / MC4100 / BW2952)
... exists to maintain high standards of patient care through clinical research and current medical thinking. Members include physicians, surgeons, pathologists, radiologists, scientists, nurses, dieticians & others.
Honorowy Członek Polskiego Towarzystwa Botanicznego Za dorobek naukowy Wyróżniony medalem im prof. Władysława Szafera e-mail: [email protected] tel.: +48 22 648 38 56 wew. 213 Wykształcenie Stu...
MCT7小鼠多克隆抗体(ab21947)可与小鼠, 大鼠, 人样本反应并经WB实验严格验证,被4篇文献引用并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity ...
Primary liver cancer (hereinafter abbreviated as PLC) is one of the most common types of malignant tumors in clinical practices. Its global prevalence is rising year-on-year and surpasses 626,000 per year. Ranking at No. 5 among all malignant tumors, its mortality rate approaches 600,000 per year and becomes No.3 of tumor-related death. As one of the prevalent regions of PLC in the world, China has a morbidity population of around 55%. Among the tumor-related death, it stands at No. 2 second only to lung cancer. So PLC has been a major hazard to health and life for Chinese citizens. Surgical resection has remained the first therapeutic choice of PLC. However, the disease course of PLC is insidious. In clinical practices, less than 30% of PLC patients may be treated surgically by hepatectomy. And their postoperative occurrences of recurrence and metastasis stay at a high level. As demonstrated by large-sample clinical trials in China, the 5-year postoperative recurrent rate of PLC was as high as ...
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
So why did the cylons return after 40 years? Was it to merge the species, sweep away the old pagan rituals, and establish the kingdom of the one God? Was it to simply exterminate humanity. (Ive never thought this was plausible.) Was it to fulfill the prophesies and return to Earth ...
Second night of episode 107 for our Battlestar Galactica campaign. The crew are tracking an archeologist from the University of Leonis that was at the Sagittaron dig thats causing all the social and political strife in our game world after they found out he was a doppleganger of a missing astronomer rom a deep-range outpost that…
CD147 antibody [4D3] (basigin (Ok blood group)) for ICC/IF, IHC-P, WB. Anti-CD147 mAb (GTX84799) is tested in Human samples. 100% Ab-Assurance.
This report studies the global Heavy Aklyl Benzenes (HAB) market status and forecast, categorizes the global Heavy Aklyl Benzenes (HAB) market size (value & volume) by key players, type, application, and region. This report focuses on the top pla
On Wed, Feb 13, 2002 at 05:14:57PM -0800, Thomas Bushnell, BSG wrote: , Debian Policy is correct by requiring everything in /etc to be a , conffile. Debian Policy would be incorrect if it required that. Fortunately, it does not. However, it does forbid configuration files from being included in binary packages unless they are listed as conffiles, which is what I think you are referring to here. , Emacs Policy, by requiring startup files, even ones that are not , configuration files, to be in /etc, thus in effect requires that they , always be conffiles. Is there any way for the admin to disable loading/autoloading of an installed elisp package other than editing these files? If not, then they should be configuration files so that this is possible. -- - mdz ...
Wir loesen das Problem ✐ Ich hab ein ziemliches Prolem, ich hab mir vor kurzem einen Trojaner oder Virus oder Malware eingefangen seitdem ist
CD147 Antigens: A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
Were told MCTs are shunted straight to the liver via the portal vein. Does the liver have a biological limit to its capacity to handle MCTs? What hap
(KudoZ) English to Hungarian translation of alcohol foam: alkoholhab / alkoholrezisztens hab [vegyszeres tűzoltás - Chemistry; Chem Sci/Eng (Tech/Engineering)].
The Bodystat 1500 is a lightweight, hand-held, battery operated Bio-impedance Analyser which is easy to use and requires no specialist skills.
nachhören] 1. FASAGA - ich hab kein Gehirn mehr 2. SUICIDAL BIRDS - i wanna be your dog 3. DEZERTER - zmiany 4. PALAIS SCHAUMBURG - grünes Winkelkanu 5. P.I.L. - chant 6. WILD YOUTH - record co´s 7. ULTRA WHITE LOVERS - girls who love me 8. FUGAZI - provisonal 9. LOLITA NO. 18 […]. ...
MCT verschafft deinem Körpr viele energiereiche Kalorien, ohne dass diese zusätzlichen Kalorien als Fett gespeichert werden können.
Basigin (BSG) is a multifunctional glycoprotein that plays an important role in male reproduction since male knockout (KO) mice are sterile. The Bsg KO testis lacks elongated spermatids and mature spermatozoa, a phenotype similar to that of alpha-mannosidase IIx (MX) KO mice. MX regulates formation of N-acetylglucosamine (GlcNAc) terminated N-glycans that participate in germ cell-Sertoli cell adhesion. Results showed that Bsg KO spermatocytes displayed normal homologous chromosome synapsis and progression through meiosis. However, only punctate expression of the round spermatid marker SP-10 in the acrosomal granule of germ cells of Bsg KO mice was detected indicating that spermatogenesis in Bsg KO mice was arrested at the early round spermatid stages. We observed a large increase in the number of germ cells undergoing apoptosis in Bsg KO testes. Using lectin blotting, we determined that GlcNAc terminated N-glycans are linked to BSG. GlcNAc terminated N-glycans were significantly reduced in Bsg KO testes
College of Arts and Sciences Biology Dr. Gregory A. Ahearn, with graduate student O. Scheffler, published "Functional characterization of a novel disaccharide transporter in lobster hepatopancreas" in the Journal of Comparative Physiology B.. Dr. Dale Casamatta, with colleagues A. Suradkar, C. Villanueva, L. Gaysina, A. Saraf, G. Dighe, R. Atnaprabha and P. Singh, published "Nostoc caldarius sp. nov.: a soil dwelling species of Nostoc(Cyanobacteria) isolated from Madhya Pradesh, India" in the International Journal of Systematic and Evolutionary Microbiology, December.. Dr. Judith D. Ochrietor and students Randall Maniccia, Kyle Russell, Kyle McBride and Josephine M. Brown presented the poster "Basigin gene products may contribute to the immunological aspects of diabetic retinopathy" at the 50th Miami Winter Symposium "Diabetes: Todays Research - Tomorrows Therapies" in January.. Dr. Vladimir Mashanov presented "Organ Regeneration in Adult Echinoderms" at the Jacksonville University Marine ...
1. The rate of uptake in 15 s of l- and d-lactate was studied in isolated hepatocyte preparations from starved rats.. 2. Observations were also made of the effect of different concentrations of unlabelled l- and d-lactate on l-[14C]- and d-[14C]-lactate uptake.. 3. Lactate uptake into hepatocytes appears to occur by two processes, one saturable and at least partially stereospecific, the other nonsaturable, at least up to 28 mmol/l, and probably representing simple non-carrier assisted diffusion.. 4. The 15 s uptake of lactate is inhibited by α-cyano-3-hydroxycinnamate and by p-chloromercuriphenylsulphonate but not by the general anion transporter inhibitor 4-acetamido-4′-isothiocyanostilbene-2,2′-disulphonic acid, ouabain or the structural analogue dl-p-hydroxyphenyl-lactate.. 5. Transporter-mediated lactate entry into liver cells is enhanced by lowered extracellular pH.. 6. It is suggested that the contribution of the diffusion component of lactate entry into the cell may be exaggerated by ...
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009 ...
mouse Slc16a7 protein: a monocarboxylate transporter; transports pyruvate and lactate; 60% identical to hamster MCT1; expressed in different cells than MCT1; RefSeq NM_011391
Jones, Robert S. et al "Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism." Molecular Pharmacology 96.3 (2019): 364-376. Web. 21 Nov. 2019. ...
CD147 antibody [MEM-M6/6] (Azide free) (basigin (Ok blood group)) for FACS, WB, Functional Assay. Anti-CD147 mAb (GTX42409) is tested in Human samples. 100% Ab-Assurance.
5) uzyskanie transgenicznych zwierząt dla potrzeb biomedycznych.. Upowszechnianie wyników badań: Jest autorem/współautorem ogółem 400 publikacji, w tym: 16 monografii, 291 oryginalnych artykułów naukowych, 109 artykułów przeglądowych, 312 wpisów do GenBank. Łączny IF 324,998, współczynnik Hirscha 17, liczba cytowań 934.. Opublikował 185 prac w czasopismach zagranicznych (N. Engl. J. Med., Mol. Plant Microbe In., Biomed Mater., Biol. Reprod., Pharm Res.) oraz 106 prac w czasopismach krajowych (Med. Weter., J. Anim. Sci., J. Appl. Genet., Biotechnologia, Endokrynol. Pol.). Współautor 14 zgłoszeń patentowych i 1 wdrożonej technologii.. Działalność dydaktyczna: Promotor 28 przewodów doktorskich, 104 prac magisterskich. Recenzował 66 prac doktorskich, 28 rozpraw hab., 25 wniosków do tytułu profesora.. Aktywność na forum międzynarodowym - stypendysta Fundacji Humboldta. Brał udział z referatem zamawianym w 13 konferencjach zagranicznych (Boston 1997, Gifu 1999, ...
34. HAB bathymetry models - R implementation of the remote sensing based Hydraulically Assisted Bathymetry models (HAB) developed by Fonstad, M. & Marcus, W. (2005). Functions are provided for modelling with a range of custom variables. Summary functions are provided as well ...
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite. None of the few known receptor-ligand interactions involved are required in all parasite strains, indicating that the parasite is able to access multiple redundant invasion pathways. Here, we show that we have identified a receptor-ligand pair that is essential for erythrocyte invasion in all tested P. falciparum strains. By systematically screening a library of erythrocyte proteins, we have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that is essential for blood stage growth. Erythrocyte invasion was potently inhibited by soluble basigin or by basigin knockdown, and invasion could be completely blocked using low concentrations of anti-basigin antibodies; importantly, these effects were observed across all ...
Saunders, Threrese Solstad; Bains, Simer Jit; Landskron, Johannes; Aandahl, Einar Martin; Thiede, Bernd; Tasken, Kjetil & Torgersen, Knut Martin (2011). CD147 (Basigin/Emmprin) identifies FoxP3(+)CD45RO(+)CTLA4(+)-activated human regulatory T cells. Blood. ISSN 0006-4971. 118(19), s 5141- 5151 . doi: 10.1182/blood-2011-02-339242 Vis sammendrag Human CD4(+)FoxP3(+)T cells are functionally and phenotypically heterogeneous providing plasticity to immune activation and regulation. To better understand the functional dynamics within this subset, we first used a combined strategy of subcellular fractionation and proteomics to describe differences at the protein level between highly purified human CD4(+)CD25(+) and CD4(+)CD25(+) T-cell populations. This identified a set of membrane proteins highly expressed on the cell surface of human regulatory T cells Tregs), including CD71, CD95, CD147, and CD148. CD147 (Basigin or Emmprin) divided CD4(+)CD25(+) cells into distinct subsets. Furthermore, CD147, ...
prof. dr hab. Paweł Rowiński, czł. koresp. PAN z Wydziału Nauk Ścisłych i Nauk o Ziemi PAN.. Zgromadzenie Ogólne Polskiej Akademii Nauk w dniu 23 maja 2013 roku wybrało profesor Elżbietę Frąckowiak członkiem korespondentem PAN w naukach technicznych ...
Theres been a lot of talk about Battlestar Galactica and its shiny metal co-stars of late, and its all coming to a head on Friday (June 12) when the 92nd street Y in Manhattan hosts a panel entitled Battlestar Galactica: Cyborgs on the Horizon. The discussion will feature several cast members from BSG as well as real live…
Bromopyruvic acid is the organic compound with the formula BrCH2COCO2H. This a colorless solid is the brominated derivative of pyruvic acid. Together with the anion bromopyruvate, BPA is lactic acid and pyruvate analogs. It has been investigated as a metabolic poison and an anticancer agent. Like other α-bromoketones, it is a strong alkylating agent. The pyruvate transporter system can be used to deliver bromopyruvate inside trypanosomal cells. Once intracellular, the primary target of 3BP is glyceraldehyde-3-phosphate dehydrogenase, which is highly sensitive to inhibition by bromopyruvate. The pyruvate transporter system, which is known to be overexpressed in cancer cells, was later identified to be a monocarboxylate transporter called monocarboxylate transporter 1. Peter L. Pedersen (2012). "3-Bromopyruvate (3BP) A Fast Acting, Promising, Powerful, Specific, and Effective "Small Molecule" Anti-Cancer Agent Taken from Labside to Bedside: Introduction to a Special Issue". J. Bioenerg. Biomembr. ...
Major findings of this study are the identification of a lactate/NF-κB signaling pathway in endothelial cells, the existence of a lactate-driven, feed-forward IL-8 autocrine loop driving angiogenesis in tumors and the key roles of monocarboxylate transporters MCT1 and MCT4 in this lactate-based dialog between cancer cells and endothelial cells. Our data indeed support a model according to which lactate released from tumor cells through MCT4 may be taken up by endothelial cells via the MCT1 transporter and consecutively stimulate angiogenesis through NF-κB/IL-8 signaling (Supplementary Fig. S1); all these lactate-driven signaling events may importantly occur in the presence of glucose.. We identified key players acting upstream and downstream of this pathway in endothelial cells. We found that ROS were produced in endothelial cells in response to lactate and that ROS inhibitors prevented lactate-induced activation of NF-κB and IL-8 expression. Also, we showed that the PHD cosubstrate ...
Ester 4:1 LUEGO que supo Mardochêo todo lo que se había hecho, rasgó sus vestidos, y vistióse de saco y de ceniza, y fuése por medio de la ciudad clamand... Read chapter in La Biblia Reina-Valera (Español)
Personally, I wouldnt wear BSG polish often though. Its not because I dont like the product though! Its just a personal thing. I didnt really like how you had the same polish on underneath for so long and when your nails did grow out, it was hard to do nail art and make it look "normal". But that isnt really their fault. Haha, this product just isnt for me! Itd be PERFECT for people that rarely have time to do their nails though or like wearing the same color for a week or two! I just have a hard time doing that haha... Another thing I didnt really like about the BSG polish is the removal process. I tried both ways they suggest -- the foil method and then soaking your nails in acetone. (More info in their FAQ page). I found that soaking your nails turned out to be easier for me and I actually timed the 5 minute thing and it wasnt ready after 5 minutes. I needed like 8 but I think the 3rd coat (which they didnt suggest but is needed) might be a factor in there. One last thing that I ...
hab ich grad vom ali bekommen.. er ist so stolz darauf endlich die geburtsseite vom hande online zu haben.. ich hab sie gleich mal gepostet, wenngleich nicht alle daten genau sind.. ihr wisst ja damals im zwischenstromland.. da ging es nicht so genau zu. da war mal die hütte zugeschneit oder das schaf ...
Hys law is a rule of thumb that a patient is at high risk of a fatal drug-induced liver injury (DILI) if given a medication that causes hepatocellular injury (not cholestatic injury) with jaundice. The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury. Some have suggested the principle be called a hypothesis or observation. Hys Law cases have three components: The drug causes hepatocellular injury, generally defined as an elevated ALT or AST by 3-fold or greater above the upper limit of normal. Often with aminotransferases much greater (5-10x) the upper limit of normal. Among subjects showing such aminotransferase elevations, they also have elevation of their serum total bilirubin of greater than 2× the upper limit of normal, without findings of cholestasis (defined as serum alkaline phosphatase activity less than 2× the upper limit of normal). No other reason can be found to explain the combination of increased aminotransferase and serum total ...

Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition...Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition...

Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and ... N2 - Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family ... AB - Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family ... Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition ...
more infohttps://pennstate.pure.elsevier.com/en/publications/extracellular-matrix-metalloproteinase-inducer-cd147-confers-resi

CD147 Antigens
      - Basigin
     Summary Report | CureHunterCD147 Antigens - Basigin Summary Report | CureHunter

CD147 Antigens: A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX ... Antigens: 114404*Surface Antigens: 4354*Differentiation Antigens: 1051*CD Antigens: 38*CD147 Antigens: 403*Gallus gallus Bsg ... CD147; Basigin Protein; CD147 Antigen; Emmprin; Emmprin Protein; Antigen, CD147 ... CD147 Antigens (Basigin). Subscribe to New Research on CD147 Antigens A widely distributed cell surface transmembrane ...
more infohttp://www.curehunter.com/public/keywordSummaryD051926.do

Gavilimomab - WikipediaGavilimomab - Wikipedia

It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy. It was ...
more infohttps://en.wikipedia.org/wiki/Gavilimomab

Gavilimomab - The Full WikiGavilimomab - The Full Wiki

It binds to the antigen CD147.[1][2]. References. *^ a b findarticles.com: Sangstat to Provide Clinical Development Update At ...
more infohttp://www.thefullwiki.org/Gavilimomab

Anti-CD147 Rabbit Polyclonal Antibody | VWRAnti-CD147 Rabbit Polyclonal Antibody | VWR

Antigen Synonyms. basigin, OK blood group antigen, 5F7, EMMPRIN, TCSF, CD147 antigen, collagenase stimulatory factor, ... Antigen: CD147. Clonality: Polyclonal. Clone: Conjugation: Unconjugated. Epitope: Host: Rabbit. Isotype: Reactivity: Human. ... extracellular matrix metalloproteinase inducer, leukocyte activation antigen M6, CD147, tumor cell-derived collagenase ... CD147 is a receptor of CypA, inducing matrix metalloproteinase expression and mediating the degradation of the extracellular ...
more infohttps://us.vwr.com/store/product/14052358/anti-cd147-rabbit-polyclonal-antibody

atypical medullary breast carcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engineatypical medullary breast carcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Antigens, CD147 / analysis. Biomarkers, Tumor / analysis. Breast Neoplasms / immunology. Carcinoma / immunology. ... Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Smad Proteins ... Antigens, CD147; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2 ... CD44v5 antigen; 0 / CD44v6 antigen; 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / Cytoskeletal Proteins; 0 / Glycoproteins; 0 ...
more infohttp://www.bmlsearch.com/?kwr=atypical+medullary+breast+carcinoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Penn State Cancer Institute - Research Output
     - Penn StatePenn State Cancer Institute - Research Output - Penn State

Salasche, S. J., Spellman, M. C., Vidimos, A. T., Alam, M., Baldwin, H. E., Billingsley, E., Drage, L. A., Kahn, T. A., Krusinski, P. A., Latkowski, J. A., Nanda, V. S., Randle, H. W., Trevino, J. J., Rabinowitz, A. D., Bello, Y. M., Stefanato, C. M. & Phillips, T. J., Jan 1 2001, In : Journal of the American Academy of Dermatology. 44, 1, p. 153-158 6 p.. Research output: Contribution to journal › Comment/debate ...
more infohttps://pennstate.pure.elsevier.com/en/organisations/penn-state-cancer-institute/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fcomment&page=7

EMMPRIN/CD147 Antibody [Unconjugated] (AF972): Novus BiologicalsEMMPRIN/CD147 Antibody [Unconjugated] (AF972): Novus Biologicals

Goat Polyclonal Anti-EMMPRIN/CD147 Antibody [Unconjugated]. Validated: WB, Simple Western, IHC. Tested Reactivity: Human. 100% ... PVDF membrane was probed with 1 µg/mL of Goat Anti-Human EMMPRIN/CD147 Antigen Affinity-purified Polyclonal Antibody (Catalog ... EMMPRIN/CD147 Antibody [Unconjugated] Summary. Immunogen. Mouse myeloma cell line NS0-derived recombinant human EMMPRIN/CD147. ... Blogs on EMMPRIN/CD147. There are no specific blogs for EMMPRIN/CD147, but you can read our latest blog posts. ...
more infohttps://www.novusbio.com/products/emmprin-cd147-antibody_af972

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             - Kyushu UniversityFind Research Outputs - Kyushu University

Ohno-Matsui, K., Kawasaki, R., Jonas, J. B., Cheung, C. M. G., Saw, S. M., Verhoeven, V. J. M., Klaver, C. C. W., Moriyama, M., Shinohara, K., Kawasaki, Y., Yamazaki, M., Meuer, S., Ishibashi, T., Yasuda, M., Yamashita, H., Sugano, A., Wang, J. J., Mitchell, P. & Wong, T. Y., May 1 2015, In : American journal of ophthalmology. 159, 5, p. 877-883.e7 9218.. Research output: Contribution to journal › Article ...
more infohttps://kyushu-u.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2015&publicationYear=2016&publicationYear=2017&publicationYear=2018&publicationYear=2019&author=5c1b8aa8-23b0-4934-8691-8c05851d9123&format=&page=1

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated MacrophagesThe Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

... and the HCC-associated antigen CD147 [99]. Experimental evidence in the literature reported that TGF-β also regulates several ... J. Wu, N. Y. Ru, Y. Zhang et al., "HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is ... Furthermore, TAMs are poor antigen-presenting cells [10, 13]. Notably, arginase expression by TAMs was previously suggested to ... Human Leukocyte Antigen), Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), and Interleukin 23 (IL-23), whereas they exhibit a ...
more infohttps://www.hindawi.com/journals/bmri/2013/187204/

Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.  - PubMed - NCBIDevelopment of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera. - PubMed - NCBI

In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and ... individual exosomes were captured in the groove of an optical disc coated with antibodies against exosome surface antigens. The ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?term=30021922

Nowak, R. A.<...Nowak, R. A.<...

CD147 Antigens Medicine & Life Sciences Myometrium Medicine & Life Sciences Endometrium Medicine & Life Sciences ...
more infohttps://experts.illinois.edu/en/persons/romana-angelika-nowak

Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters -...Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters -...

Combined cell surface carbonic anhydrase 9 and CD147 antigens enable high-efficiency capture of circulating tumor cells in ... The Roles of CD147 and/or Cyclophilin A in Kidney Diseases. Xin Qu, Chunting Wang, Jicheng Zhang, Guoqiang Qie, Jianxin Zhou ... Prognostic value of CD 147 and HIF-2 α expression in localized clear cell renal cell carcinoma. Hao Li, Tian Zhang, +3 authors ... CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis. Xiaoyan Xin, Xianqin Zeng, +6 ...
more infohttps://www.semanticscholar.org/paper/Association-of-EMMPRIN-and-fascin-expression-in-Tsai-Sheu/3e58783c49edc4de047cbc43a8c66da4de1be480

Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: Role in...Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: Role in...

Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: Role in ... Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: Role in ... Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas : Role in ... Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas : Role in ...
more infohttps://augusta.pure.elsevier.com/en/publications/differential-expression-of-extracellular-matrix-metalloproteinase

CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling<...CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling<...

CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling. In: American Journal of Pathology. ... CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling. American Journal of Pathology. 2019 ... CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling. / Yoshioka, Tomoki; Kosugi, Tomoki ... Yoshioka, T., Kosugi, T., Masuda, T., Watanabe, T., Ryuge, A., Nagaya, H., ... Kadomatsu, K. (2019). CD147/Basigin Deficiency ...
more infohttps://pure.fujita-hu.ac.jp/en/publications/cd147basigin-deficiency-prevents-the-development-of-podocyte-inju

Gendoo - Relevant featuresGendoo - Relevant features

Antigens, CD147 CD147抗原 Avian Proteins 鳥類蛋白質 Zebrafish Proteins ゼブラフィッシュ蛋白質 ...
more infohttp://gendoo.dbcls.jp/cgi-bin/gendoo.cgi?omimid=162096&taxonomy=human

重组人CD147蛋白(ab114196)|Abcam中国重组人CD147蛋白(ab114196)|Abcam中国

CD147 antigen. *Collagenase stimulatory factor. *EMMPRIN. *Extracellular matrix metalloproteinase inducer. *Leukocyte ...
more infohttp://www.abcam.cn/recombinant-human-cd147-protein-ab114196.html

BSG monoclonal antibody, clone MEM-M6/2 - (MAB3633) - Products - AbnovaBSG monoclonal antibody, clone MEM-M6/2 - (MAB3633) - Products - Abnova

CD147 antigen,M6 leukocyte activation antigen,OK blood group antigen,basigin,collagenase stimulatory factor,extracellular ... CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling.. Ruiz S, Castro-Castro ... Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=MAB3633

CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features | BMC...CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features | BMC...

Decreased CD147 was associated with advanced pathologic stage (p = 0.009) and high Gleason score (p = 0.02), and low CD147 ... and CD147 expression was lower in tumorigenic T10 cells than non-tumorigenic BPH-1 cells (p = 0.02). Decreased CD147 mRNA ... CD147 specificity and expression were confirmed with immunoblotting of prostate cell lines, and CD147 mRNA expression was ... Expression of CD147 protein was significantly decreased in localized tumors (pT2; p = 0.02) and aggressive PCa (≥pT3; p = 0.004 ...
more infohttps://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12885-015-1559-4

List of MeSH codes (D23) - WikipediaList of MeSH codes (D23) - Wikipedia

... antigens, cd147 MeSH D23.050.301.264.035.264 --- antigens, cd164 MeSH D23.050.301.264.035.270 --- antigens, thy-1 MeSH D23.050. ... antigens, cd147 MeSH D23.101.100.110.264 --- antigens, cd164 MeSH D23.101.100.110.270 --- antigens, thy-1 MeSH D23.101.100.110. ... antigens, cd24 MeSH D23.050.285.025 --- antigens, cd30 MeSH D23.050.285.040 --- antigens, cd147 MeSH D23.050.285.050 --- ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)

Identification of new participants in the rainbow trout (Oncorhynchus mykiss) oocyte maturation and ovulation processes using...Identification of new participants in the rainbow trout (Oncorhynchus mykiss) oocyte maturation and ovulation processes using...

BASI_HUMAN (P35613) Basigin precursor (CD147 antigen) (Leukocyte activation antigen M6) (Collagenase stimulatory factor) ... PTPRF_HUMAN (P10586) Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen ... HM13_MOUSE (Q9D8V0) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) ...
more infohttps://rbej.biomedcentral.com/articles/10.1186/1477-7827-4-39
  • Plasma membrane-localized CD147 protein expression was quantified in patient samples using immunohistochemistry and multispectral imaging, and expression was compared to clinico-pathological features (pathologic stage, Gleason score, tumor volume, preoperative PSA, lymph node status, surgical margins, biochemical recurrence status). (beds.ac.uk)
  • Membrane-associated CD147 expression is significantly decreased in PCa compared to non-malignant prostate tissue and is associated with tumor progression, and low CD147 expression predicts biochemical recurrence after prostatectomy independent of pathologic stage, Gleason score, lymph node status, surgical margins, and tumor volume in multivariable analysis. (beds.ac.uk)
  • In this system, individual exosomes were captured in the groove of an optical disc coated with antibodies against exosome surface antigens. (nih.gov)
  • It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. (vwr.com)
  • CD147 is a receptor of CypA, inducing matrix metalloproteinase expression and mediating the degradation of the extracellular matrix, plays an important role in tumorigenesis and invasion in oral cancer. (vwr.com)
  • In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and human epidermal growth factor receptor 2 (HER2) were also used to quantify cancer cell line-derived exosomes. (nih.gov)
  • Iacono KT, Brown AL, Greene MI, Saouaf SJ: CD147 immunoglobulin superfamily receptor function and role in pathology. (exbio.cz)
  • CD147 specificity and expression were confirmed with immunoblotting of prostate cell lines, and CD147 mRNA expression was evaluated in public expression microarray datasets of patient prostate tumors. (beds.ac.uk)
  • The purpose of this study was to investigate the expression of CD147 in prostate cancer (PCa) progression and the prognostic ability of CD147 in predicting biochemical recurrence after prostatectomy. (beds.ac.uk)
  • Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human CD147. (abcam.co.jp)
  • Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer). (exbio.cz)
  • A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of human IgG1. (exbio.cz)
  • Xu D, Hemler ME: Metabolic activation-related CD147-CD98 complex. (exbio.cz)
  • Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP: CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. (exbio.cz)
  • Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (abcam.co.jp)
  • CD147 is an MMP-inducing protein often implicated in cancer progression. (beds.ac.uk)
  • However, two recent studies have reported contrary results, with a decrease in CD147 observed with PCa progression [ 13 , 14 ], suggesting that CD147 may play a protective role in PCa. (beds.ac.uk)