Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1/ICAM-1 pathway. (1/318)
CD147 is a 50 000-60 000 MW glycoprotein of the immunoglobulin superfamily broadly expressed on haemopoietic cell lines and peripheral blood cells. In the present study, six monoclonal antibodies (mAbs) directed against the CD147 protein were generated. The antigen defined by the generated CD147 mAbs is widely expressed on haemopoietic cell lines, peripheral blood cells and is a lymphocyte activation-associated cell surface molecule. The generated CD147 mAbs precipitated a broad protein band from U937 cells of 45 000-65 000 MW under reducing conditions. Functional analysis indicated that the CD147 mAbs markedly induced homotypic cell aggregation of U937 cells, but not K562 cells. The CD147 mAb-induced cell aggregation was inhibited by leucocyte function-antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) mAbs. However, the expression of LFA-1 and ICAM-1 molecules on U937 was not altered by CD147 mAb treatment. The U937 cell aggregation induced by CD147 mAb was also inhibited by ethylenediamine tetra-acetic acid (EDTA), sodium azide and when incubated at 4 degrees. We therefore propose that the binding of CD147 mAb to CD147 molecule, which mimics the natural ligand binding, may generate intracellular signals that activate LFA-1/ICAM-1 intercellular adhesion pathway. (+info)T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density. (2/318)
CD147 is a broadly expressed cell surface glycoprotein of the Ig superfamily whose expression is up-regulated upon T cell activation. In order to elucidate a possible role of CD147 in T cell biology, we established 15 specific mAb. Seven distinct epitopes were defined by the mAb panel. Most of the mAb bound only to phytohemagglutinin (PHA)-activated but not resting T cells. We demonstrate that this was not because of true expression of activation-dependent neoepitopes but rather due to bivalent binding of the relatively low-affinity mAb (affinity constant KA values between 2.25 x 10(8) and 7 x 10(9) M-1) to the more densely expressed and/or more clustered CD147 molecules on the activated T cells. In contrast, the mAb with higher affinity (KA > 7 x 10(9) M-1) could stably bind in a monovalent fashion even to the relatively low dense CD147 molecules on resting T cells. This model might more generally explain the nature of 'activation epitopes' described previously in other leukocyte surface molecules. Finally, we provide evidence that induction of ordered dimerization of CD147 by a mAb directed to a unique epitope results in strong inhibition of CD3-mediated T cell activation. (+info)Differential expression of novel abundant and highly regionalized mRNAs of the canine epididymis. (3/318)
Three novel gene products have been cloned by differential screening of a dog epididymis cDNA library as part of a global appraisal of specific gene expression in the epididymis. The predicted proteins were provisionally named CE8-CE10 (for canine epididymal gene products 8-10). Northern blot analyses and in situ transcript hybridization confirmed that the cDNAs were all derived from tissue-specific, moderately to highly abundant mRNAs of the epididymal epithelium, showing a distinct regionalized expression pattern within the epididymal duct. Their sequences predict (i) a novel 19 kDa member of the Ly-6-domain protein superfamily (CE8), (ii) an approximately 30 kDa protein with multiple membrane-spanning regions (CE9), and (iii) a novel approximately 13 kDa single whey acidic protein domain protein (CE10). Closely related, cross-hybridizing gene products were abundant in the epididymis of stallions and bulls, but not in rodents or men. Changes in mRNA frequency were observed that specifically correlated with a cryptorchid situation and with the age of the dogs. Gene products restricted to the caput epididymidis were affected by both conditions, while those with a wider regional distribution were not. (+info)Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium. (4/318)
OBJECTIVE: To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the synovial membrane of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS: Mouse monoclonal antibody against human EMMPRIN was applied according to an avidin-biotin-peroxidase complex method to reveal EMMPRIN expression. Western blotting and reverse transcriptase-polymerase chain reaction (RT-PCR) were performed to check for the presence of EMMPRIN protein and messenger RNA (mRNA). RESULTS: EMMPRIN immunoreactivity was more intense in RA than in OA synovial membrane (P < 0.01). EMMPRIN staining was more widespread in RA than in OA, especially in association with macrophage infiltrates. RT-PCR of synovial membrane samples disclosed the presence of EMMPRIN mRNA. Nucleotide sequencing of the PCR amplification products confirmed the identity of the amplified bands. Immunoblot analysis revealed 55-kd glycosylated EMMPRIN bands, which were particularly prominent in RA samples. CONCLUSION: The expression of EMMPRIN is upregulated in the rheumatoid synovial membrane. EMMPRIN can induce local production of at least MMPs 1, 2, and 3, and can thereby play a role in joint destruction in RA. (+info)EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface. (5/318)
Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at the tumor cell surface. Complex formation was demonstrated by phage display, affinity chromatography, and immunocytochemistry. Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in modifying the tumor cell pericellular matrix to promote invasion. (+info)The expression and cellular localization of the sperm flagellar protein MC31/CE9 in the rat testis: possible posttranscriptional regulation during rat spermiogenesis. (6/318)
We isolated the MC31 cDNA clone coding the antigen specifically recognized by the monoclonal antibody mMC31, and found that MC31 was identical to rat CE9. Therefore, this molecule is called MC31/CE9. MC31/CE9, a member of the immunoglobulin superfamily molecules, was localized on the rat sperm flagellar plasma membrane. We analyzed the expression and cellular localization of MC31/CE9 mRNA and protein in the adult rat testis by use of Northern hybridization, in situ hybridization, and immunohistochemical analyses. In the course of spermatogenesis, MC31/CE9 mRNA first appeared in type B spermatogonia. The mRNA signal intensity increased progressively to pachytene spermatocytes and remained constantly at a considerable level throughout the subsequent phases of spermatocytes and round spermatids, and then decreased gradually from step-11 spermatids to disappear in step-15 spermatids. On the other hand, MC31/CE9 protein expression showed a bimodal pattern. Immunohistochemical analysis for the MC31/CE9 protein revealed its most intense immunoreactivity on the flagella of step-8 to step-19 elongated spermatids. The cytoplasmic immunoreactivity of the MC31/CE9 protein also appeared in preleptotene to early pachytene spermatocytes and elongated spermatids, with particularly intense immunoreactivity in the Golgi complexes of zygotene and early pachytene spermatocytes (stage XIII to III) as well as step-8 to step-13 spermatids. Between these two phases, the MC31/CE9 protein proved undetectable in the cytoplasm of any spermatogenic cells. Sertoli cells and Leydig cells were devoid of MC31/CE9 mRNA and its protein. Therefore, the production of MC31/CE9 is thought to be posttranscriptionally regulated during spermiogenesis. (+info)Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia. (7/318)
Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion. Many biochemical and molecular markers of chondrocyte hypertrophy are absent from the lesion, or show reduced expression, but the cause of the disorder remains to be identified. As differentiation to the hypertrophic state is impaired in TD, we hypothesised that chondrocyte genes that are differentially expressed in the growth plate should show altered expression in TD. Using differential display, four genes, B-cadherin, EF2, HT7 and Ex-FABP were cloned from chondrocytes stimulated to differentiate to the hypertrophic stage in vitro, and their differential expression confirmed in vivo. Using semi-quantitative RT-PCR, the expression patterns of these genes were compared in chondrocytes from normal and TD growth plates. Surprisingly, none of these genes showed the pattern of expression that might be expected in TD lesion chondrocytes, and two of them, B-cadherin and Ex-FABP, were upregulated in the lesion. This indicates that the TD phenotype does not merely reflect the absence of hypertrophic marker genes, but may be influenced by more complex developmental mechanisms/defects than previously thought. (+info)Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. (8/318)
Basigin (Bsg) is a highly glycosylated transmembrane protein with two immunoglobulin (Ig)-like domains. A number of studies, including gene targeting, have demonstrated that Bsg plays pivotal roles in spermatogenesis, implantation, neural network formation and tumor progression. In the present study, to understand the mechanism of action of Bsg, we determined its expression status on the plasma membrane. Cotransfection of Bsg expression vectors with two different tags clarified that Bsg forms homo-oligomers in a cis-dependent manner on the plasma membrane. If the disulfide bond of the more N-terminally located Ig-like domain was destroyed by mutations, Bsg could not form oligomers. In contrast, the mutations of the C-terminal Ig-like domain or N-glycosylation sites did not affect the association. The association of mouse and human Bsgs, which exhibit high homology in the transmembrane and intracellular domains but low homology in the extracellular domain, was very weak as compared with that within the same species, suggesting the importance of the extracellular domain in the association. If the extracellular domain of the human Ret protein was replaced with the N-terminal Ig-like domain of Bsg, the resulting chimera protein was associated with intact wild-type Bsg, but not if the C-terminal Ig-like domain, instead of the N-terminal one, of Bsg was used. No oligomer formation took place between the intact wild-type Ret and Bsg proteins. In conclusion, these data indicate that the N-terminal Ig-like domain is necessary and sufficient for oligomer formation by Bsg on the plasma membrane. (+info)Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition...
Abstract 3865: Interleukin-18 is a Potent Inducer of EMMPRIN Expression Both in vitro and in vivo, and Their Crosstalk Induces...
CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts | BMC Cancer | Full Text
CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts | BMC Cancer | Full Text
Exbio antibodies - Mouse Monoclonal to CD147 / Basigin / Neurothelin MEM-M6/6 (IgG1)
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H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading...
Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture | Journal of Cell Science
Basigin elisa and antibody
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EMMPRIN down-regulation by scFv-M6-1B9 intrabody affect | Open-i
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Gavilimomab
It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy. It was ...
Basigin
"The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin ... It have been shown that Atorvastatin suppresses CD147 and MMP-3 expression. Statins altered CD147 expression, structure and ... December 2020). "CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells". Signal Transduction and Targeted ... There are three known antigens in the Ok system; the most common being Oka (also called OK1), OK2 and OK3. Basigin has been ...
List of MeSH codes (D23)
... antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, cd147 MeSH D23.050.285.050 - antigens, ... antigens, cd147 MeSH D23.050.301.264.035.264 - antigens, cd164 MeSH D23.050.301.264.035.270 - antigens, thy-1 MeSH D23.050. ... antigens, cd147 MeSH D23.101.100.110.264 - antigens, cd164 MeSH D23.101.100.110.270 - antigens, thy-1 MeSH D23.101.100.110.280 ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ...
KLF1
CD147 ie EMMPRIN), Indian(CD44), Duffy (Duffy antigen/chemokine receptor or Fy), Scianna (ERMAP), MN (glycophorin A), Diego( ... Antigens on RBC membrane, and some of which might overlap with KLF1 mutations causing the fraction of hereditary persistence of ... Permissive nature of the role of KLF1 on expression of several RBC antigens are evidenced by a series of known KLF1 mutations ... but there is an apparent dominant negative effect on expression of Lutheran Antigen (Basal cell adhesion Molecule) after which ...
Sandra Saouaf
1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of Biological Chemistry. ... Iacono, Kathryn T.; Brown, Amy L.; Greene, Mark I.; Saouaf, Sandra J. (December 2007). "CD147 Immunoglobulin Superfamily ... "Temporal Differences in the Activation of Three Classes of Non-Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen ...
Chromosome 19
The enzyme it encodes catalyzes the production of H antigen. MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus ... Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... 5: The ABO blood group". Blood Groups and Red Cell Antigens. Bethesda MD: National Center for Biotechnology Information. ... Gene map locus 19q13.32 PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32 DMPK: Dystrophia myotonica-protein kinase. ...
Apolipoprotein D
The transmembrane glycoprotein Basigin (BSG; CD147) was identified as an ApoD receptor. BSG is a membrane glycoprotein receptor ... "Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues". The ... Iacono, KT; Brown, AL; Greene, MI; Saouaf, SJ (December 2007). "CD147 immunoglobulin superfamily receptor function and role in ...
Ubiquitin C
Wang WJ, Li QQ, Xu JD, Cao XX, Li HX, Tang F, Chen Q, Yang JM, Xu ZD, Liu XP (2008). "Interaction between CD147 and P- ... "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proceedings of the ... "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled ...
TRA-1-85 (CD147) Antibody, anti-human, REAfinity™ | Recombinant antibodies | MACS Antibodies | Products | Miltenyi Biotec |...
... which is also known as CD147, basigin, or extracellular matrix metalloproteinase inducer (EMMPRIN). TRA-1-85 is expressed by ... Clone REA476 recognizes the human TRA-1-85 antigen, a single-pass type I membrane protein, ... Clone REA476 recognizes the human TRA-1-85 antigen, a single-pass type I membrane protein, which is also known as CD147, ... Clone REA476 recognizes the human TRA-1-85 antigen, a single-pass type I membrane protein, which is also known as CD147, ...
Article published by Hannes Stockinger recommended in F1000Prime as being of special significance in the field of Immunology by...
The article - T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by ... antibody affinity and antigen density., International Immunology, 1999 (DOI: 10.3410/f.1000986.793520162) - ... Using the cell surface CD147 protein as a model, it is demonstrated that protein clustering enables increased bivalent ... as it describes the systematic analysis of binding of antibodies of varying affinities to T cells expressing CD147 and of ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. | JACC...
CD147 Endothelial Cells + Antigens, CD147 Endothelial Cells + LOCATION_OF + Antigens, CD147 ... Endothelial Cells + LOCATION_OF LOCATION_OF + Antigen Endothelial Cells + Antigen Endothelial Cells + LOCATION_OF + Antigen ... Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. ... Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With ...
DeCS 2018 - Changed terms
Antigens, CD14. Lipopolysaccharide Receptors. Antigens, CD146. CD146 Antigen. Antigens, CD147. Basigin. Antigens, CD15. Lewis X ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD14. Lipopolysaccharide Receptors. Antigens, CD146. CD146 Antigen. Antigens, CD147. Basigin. Antigens, CD15. Lewis X ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD14. Lipopolysaccharide Receptors. Antigens, CD146. CD146 Antigen. Antigens, CD147. Basigin. Antigens, CD15. Lewis X ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD14. Lipopolysaccharide Receptors. Antigens, CD146. CD146 Antigen. Antigens, CD147. Basigin. Antigens, CD15. Lewis X ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS Ingl s
Anti-OX115 [OX115] monoclonal antibody | Monoclonal Antibodies - Ximbio
Blood group antigens. Medical search
Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... ... The blood group antigen is an A antigen, ... Blood group antigens include A antigen, B antigen and H antigen. Core saccharide ... Exogenous antigens[edit]. Exogenous antigens are antigens that have ... T-independent antigen - Antigens that stimulate B cells ... TumorForssman AntigenCarbohydratesHLA-DR AntigensReceptors, Antigen, T-CellAntigens, CD15O Antigens ...
Pesquisa | Prevenção e Controle de Câncer
Potential target antigens for radioimmunotherapy in Hepatocellular carcinoma (HCC). HCC radioimmunotherapy target antigens are ... CD147 could all be used in HCC radioimmunotherapy. Abbreviations: TAMs, tumor-associated macrophages; CTLA-4, cytotoxic T- ... Novel antigens for targeted radioimmunotherapy in hepatocellular carcinoma. Pourhamzeh, Mahsa; Asadian, Samieh; Mirzaei, Hamed ... CTLA-4 ligand and receptor, TAMs, PD-1/PD-L, TIM-3, specific IEXs/TEXs, ROBO1, and cluster of differentiation antigens CD105, ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
E5.478.594.49 Antigens, CD147 D12.776.543.550.188 D12.776.543.550.187 Antigens, CD28 D12.776.543.750.705.816.824.133 D12.776. ... 543.750.705.222.500 Antigens, CD70 D12.776.543.550.172 D12.776.543.550.170 Antigens, CD8 D23.50.301.264.35.108 Antigens, CD80 ... D23.529.168.100 Antigens, CD86 D12.776.395.550.17 D12.776.467.150.200 D12.776.543.550.186 D12.776.543.95.200 D23.50.301.264. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ...
Antigens, Thy-1 | Profiles RNS
Antigens, CD11. *Antigens, CD13. *Antigens, CD137. *Antigens, CD14. *Antigens, CD146. *Antigens, CD147 ... "Antigens, Thy-1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, Thy-1" by people in this website by year, and ... A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally ...
Antigens, CD18 | Profiles RNS
Antigens, CD146. *Antigens, CD147. *Antigens, CD15. *Antigens, CD151. *Antigens, CD164. *Antigens, CD18 ... "Antigens, CD18" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, CD18" by people in UAMS Profiles by year, and ... Below are the most recent publications written about "Antigens, CD18" by people in Profiles over the past ten years. ...
Antigens, CD36 | Profiles RNS
Antigens, CD11. *Antigens, CD13. *Antigens, CD137. *Antigens, CD14. *Antigens, CD146. *Antigens, CD147 ... "Antigens, CD36" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antigens, CD36" by people in this website by year, and whether ... Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS ...
Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein - The Jenner Institute
Basigin, or CD147, was previously identified as a possible therapeutic target based on the observation that it may act as a co- ... or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well-established role ... Antigen Discovery / Immunopeptidomics * Vaccine Delivery Technologies * Vector Engineering * Veterinary Vaccines Partnership * ... AbstractBasigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well- ...
October 5, 2021 - Medical Mitogen-activated protein kinases (MAPK) Research
Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen ... peptidyl-prolyl cis-trans isomerase exercise that features as a transcriptional inducer for Stat5 and as a ligand for CD147. To ... The principle purpose of this examine was to evaluate the diagnostic worth of the recombinant SAG1 antigen (rSAG1) for T. ... We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be utilized to characterize ...
"The interaction of HAb18G/CD147 with integrin alpha6beta1 and its impl" by Jing-yao Dai, Ke-feng Dou et al.
RESULTS: We found that integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 in human hepatoma cells. The enhancing ... METHODS: Human SMMC-7721 and FHCC98 cells were cultured and transfected with siRNA fragments against HAb18G/CD147. The ... Co-immunoprecipitation and Western blot analyses were performed to examine the native conformations of HAb18G/CD147 and ... CONCLUSION: These results suggest that alpha6beta1 interacts with HAb18G/CD147 to mediate tumor invasion and metastatic ...
SARS-CoV-2 SA Variant Neutralization - The Native Antigen Company
Human CD147 (22-205) Recombinant Protein, Fc-Tag (CHO). $584.35. - $810.65. excl. VAT ... SKU: NTRL-SA-RBD Categories: Antigens & Antibodies, Human Coronavirus antigens, Human Coronavirus NTRL Kits, Immunoassays Tag: ... Home / Products / All Products / Antigens & Antibodies / SARS-CoV-2 Neutralization Assay Development Kit (South African Variant ... The Native Antigen Company is part of LGC Clinical Diagnostics - Learn More ...
IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology
... monoclonal antibodies recognizing tumor antigens, chemotherapy, or molecular targeted agents. Clinical phase I-II studies of IL ... Human T cells genetically engineered to express a chimeric antigen receptor (CAR) specific for the CD19 B cell antigen and ... CD147+ granzyme B+ regulatory phenotype, together with the expression of other immune-regulatory molecules such as IL-10, CD25 ... Indeed CD8+ T cells accumulate in Socs1−/− mice [42]. In vitro studies also showed that IL-21 inhibited the antigen-induced ...
February | 2020 | Fak Pathway
Conclusions This report showed that the silencing of CD147 by RNA. Posted on February 24, 2020. by fakp8655 ... and prostate specific antigen at diagnosis (mean, 8.2 and 95% CI, 5.3-11.2 ng/dL) presented low dispersion of values between ... Cancer Res 1993, 53:3154-3158.PubMed 6. Nabeshima K, Iwasaki H, Koga K, Hojo H, Suzumiya J, Kikuchi M: Emmprin (basigin/CD147 ... Conclusions This report showed that the silencing of CD147 by RNAi inhibited the proliferation and invasion of human gastric ...
Receptors, KIR3DL1 | Harvard Catalyst Profiles | Harvard Catalyst
Antigens, CD11. *Antigens, CD13. *Antigens, CD137. *Antigens, CD14. *Antigens, CD146. *Antigens, CD147 ... A KIR receptor that has specificity for HLA-B ANTIGENS. It is an inhibitory receptor that contains D0, D1, and D2 extracellular ... Impact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in ...
Genetic Analysis of Common Variants of MMPs and their Involvement in Rheumatoid Arthritis in the East Midlands, UK | SciTechnol
Elshazli R, Settin A, Salama A (2015) Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) +49 A,G gene polymorphism in ... 2013) Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral monocytes in patients with active rheumatoid ... The human leukocyte antigen (HLA) region accounts for around 30% of genetic variance in RA. However, other areas of the genome ...
Human Emmprin ELISA Kit EZ-Set™
5F7; basigin (Ok blood group); Basigin; BSG; CD147 antigen; CD147; Collagenase stimulatory factor; EMMPRIN; EMMPRINTCSF; ... OK blood group antigen; OK; Tumor cell-derived collagenase stimulatory factor BSG 5F7, CD147, EMMPRIN, EMPRIN, HAb18G, OK, ... hepatoma-associated antigen,leukocyte activation antigen M6,tumor cell-derived collagenase stimulatory factor ... SLC7A11, TCSF basigin (Ok blood group) basigin,OK blood group antigen,collagenase stimulatory factor,extracellular matrix ...
Basigin2
- Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. (bvsalud.org)
- Basigin, or CD147, was previously identified as a possible therapeutic target based on the observation that it may act as a co-receptor for SARS-COV-2, binding to the receptor binding domain of the spike protein. (jenner.ac.uk)
Receptors1
- Through no fault of our own, we are causing some serious micro-clotting issues all over this person's body by binding all these ACE-2 (Angiotensin-converting enzyme 2 gene) and CD147 ( pattern recognition molecule in the innate immune response) receptors. (antiaginglady.com)
Differentiation1
- A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. (rush.edu)
Antibodies9
- Human peripheral blood mononuclear cells (PBMCs) were stained with Anti-TRA-1-85 (CD147) antibodies or with the corresponding REA Control (S) antibodies (left peak). (miltenyibiotec.com)
- This older paper is still highly relevant, as it describes the systematic analysis of binding of antibodies of varying affinities to T cells expressing CD147 and of activated T cells, which have increased levels of expression. (meduniwien.ac.at)
- The important findings are that low-affinity antibodies may not give detectable binding in typical labelling experiments unless there is sufficient antigen density, as found on activated T cells. (meduniwien.ac.at)
- Antibodies present in the recipient's serum may be directed against antigens in the donor product. (lookformedical.com)
- Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. (lookformedical.com)
- Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. (medmk.com)
- The enhancing effects of HAb18G/CD147 on invasion capacity and secretion of matrix metalloproteinases (MMPs) were partially blocked by integrin alpha6beta1 antibodies (P (jefferson.edu)
- Moreover, IL-21's antitumor activity can be potentiated by its combination with other immune-enhancing molecules, monoclonal antibodies recognizing tumor antigens, chemotherapy, or molecular targeted agents. (hindawi.com)
- Also, it's possible that mRNA delivery may change the way antigens are presented to the immune system, leading to differences in the antibodies that get produced. (nih.gov)
Integrin7
- The interaction of HAb18G/CD147 with integrin alpha6beta1 and its impl" by Jing-yao Dai, Ke-feng Dou et al. (jefferson.edu)
- The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. (jefferson.edu)
- Our previous study demonstrated that overexpression of HAb18G/CD147 promotes invasion by interacting with integrin alpha3beta1. (jefferson.edu)
- However, it has never been investigated whether alpha3beta1 is solely responsible for this process or if other integrin family members also interact with HAb18G/CD147 in human hepatoma cells. (jefferson.edu)
- The expression levels of HAb18G/CD147 and integrin alpha6beta1 were determined by immunofluorescent double-staining and confocal imaging analysis. (jefferson.edu)
- Co-immunoprecipitation and Western blot analyses were performed to examine the native conformations of HAb18G/CD147 and integrin alpha6beta1. (jefferson.edu)
- RESULTS: We found that integrin alpha6beta1 co-localizes and interacts with HAb18G/CD147 in human hepatoma cells. (jefferson.edu)
Glycoprotein1
- CD133 antigen , also known as prominin-1 , is a glycoprotein that in humans is encoded by the PROM1 gene . (wikidoc.org)
Molecule1
- An important role of Natural Killer (NK) cells is to eliminate other cells that extinguish or diminish expression of self-MHC class I molecule s or Human Leukocyte Antigen (HLA), which commonly occurs as a result of viral infection or cellular transformation. (codondex.com)
Receptor3
- AbstractBasigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. (jenner.ac.uk)
- A KIR receptor that has specificity for HLA-B ANTIGENS. (harvard.edu)
- Impact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers. (harvard.edu)
Protein2
- Cyclophilin B (CypB) is a 21-kDa protein with peptidyl-prolyl cis-trans isomerase exercise that features as a transcriptional inducer for Stat5 and as a ligand for CD147. (medmk.com)
- SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. (pneumon.org)
Proteins1
- These so-called antigen-presenting cells just love to gobble up foreign proteins like us and regurgitate our entrails and mount them on major histocompatibility complex (MHC) I and II molecules. (antiaginglady.com)
Leukocyte1
- The human leukocyte antigen (HLA) region accounts for around 30% of genetic variance in RA. (scitechnol.com)
Antibody1
- The article - T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density . (meduniwien.ac.at)
Serum1
- Treatment options for PC depended on clinicopathological features, such as Gleason score, TNM stage, serum prostate-specific antigen (PSA) and surgical margin status. (ijpsonline.com)
Tumor1
- CONCLUSION: These results suggest that alpha6beta1 interacts with HAb18G/CD147 to mediate tumor invasion and metastatic processes through the PI3K pathway. (jefferson.edu)
Recombinant1
- The principle purpose of this examine was to evaluate the diagnostic worth of the recombinant SAG1 antigen (rSAG1) for T. gondii-IgG screening by means of the Human Toxo IgG ELISA Equipment (Okay). (medmk.com)
Surface2
- Sets of cell surface antigens located on BLOOD CELLS. (lookformedical.com)
- Myeloid cell surface antigen CD33. (invivogen.com)
PI3K1
- Wortmannin, a specific phosphatidylinositol kinase (PI3K) inhibitor that reverses the effect of HAb18G/CD147 on the regulation of intracellular Ca2+ mobilization, significantly reduced cell invasion potential and secretion of MMPs in human hepatoma cells (P (jefferson.edu)
Genes3
- Multiple erythrocytic antigens that comprise at least three pairs of alternates and amorphs, determined by one complex gene or possibly several genes at closely linked loci. (lookformedical.com)
- A group of antigens consisting principally of Jk(a) and Jk(b), determined by allelic genes. (lookformedical.com)
- A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor. (lookformedical.com)
Erythrocyte1
- At least five different erythrocyte antigens are possible, some very rare, others almost universal. (lookformedical.com)
Cells4
- Antigens on surfaces of cells, including infectious or foreign cells or viruses. (lookformedical.com)
- BACKGROUND: HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. (jefferson.edu)
- METHODS: Human SMMC-7721 and FHCC98 cells were cultured and transfected with siRNA fragments against HAb18G/CD147. (jefferson.edu)
- Hamilton-Easton AM, Eichelberger M. Microbiology virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice. (pneumon.org)
Human1
- The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. (lookformedical.com)
Found1
- A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. (lookformedical.com)
Major2
- The major antigen Rh or D is the most common cause of erythroblastosis fetalis. (lookformedical.com)
- This graph shows the total number of publications written about "Antigens, Thy-1" by people in this website by year, and whether "Antigens, Thy-1" was a major or minor topic of these publications. (rush.edu)
People1
- Below are the most recent publications written about "Antigens, Thy-1" by people in Profiles. (rush.edu)
Group2
- Blood group antigens. (lookformedical.com)
- A group of dominantly and independently inherited antigens associated with the ABO blood factors. (lookformedical.com)
Subject1
- Antigens, Thy-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)