The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Used as feed supplement for sheep and cattle since it is a good non-protein nitrogen source. In strongly alkaline solution biuret gives a violet color with copper sulfate.
The motion of a liquid through a membrane (or plug or capillary) consequent upon the application of an electric field across the membrane. (Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Endogenous compounds and drugs that bind to and activate GABA-B RECEPTORS.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Immunoglobulins produced in response to VIRAL ANTIGENS.
Organic or inorganic compounds that contain the -N3 group.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Tumors or cancer of the LUNG.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Leisure activities engaged in for pleasure.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Sodium excretion by URINATION.
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Kallidin- and bradykinin-degrading pathways in human heart: degradation of kallidin by aminopeptidase M-like activity and bradykinin by neutral endopeptidase. (1/485)

BACKGROUND: Since kinins kallidin (KD) and bradykinin (BK) appear to have cardioprotective effects ranging from improved hemodynamics to antiproliferative effects, inhibition of kinin-degrading enzymes should potentiate such effects. Indeed, it is believed that this mechanism is partly responsible for the beneficial effects of angiotensin-converting enzyme (ACE) inhibitors. In the heart, enzymes other than ACE may contribute to local degradation of kinins. The purpose of this study was to investigate which enzymes are responsible for the degradation of KD and BK in human heart tissue. METHODS AND RESULTS: Cardiac membranes were prepared from the left ventricles of normal (n=5) and failing (n=10) hearts. The patients had end-stage congestive heart failure as the result of coronary heart disease or idiopathic dilated cardiomyopathy. Heart tissue was incubated with KD or BK in the presence or absence of enzyme inhibitors. We found no difference in the enzymes responsible for kinin metabolism or their activities between normal and failing hearts. Thus KD was mostly converted into BK by the aminopeptidase M-like activity. When BK was used as substrate, it was converted into an inactive metabolite BK-(1-7) mostly (80% to 90%) by the neutral endopeptidase (NEP) activity, with ACE unexpectedly playing only a minor role. The low enzymatic activity of ACE in the cardiac membranes, compared with that of NEP, was not due to chronic ACE inhibitor therapy, because the cardiac ACE activities of patients, whether receiving ACE inhibitors or not, and of normal subjects were all equal. CONCLUSIONS: The present in vitro study shows that in human cardiac membranes, the most critical step in kinin metabolism, that is, inactivation of BK, appears to be mediated mostly by NEP. This observation suggests a role for NEP in the local control of BK concentration in heart tissue. Thus inhibition of cardiac NEP activity could be cardioprotective by elevating the local concentration of BK in the heart.  (+info)

Immunophenotype of myeloid cells in myelodysplastic syndromes and its clinical implications. (2/485)

OBJECTIVE: To explore the immunophenotype of myeloid cells in myelodysplastic syndyomes (MDS) and its clinical implications. METHODS: A panel of monoclonal antibody was used to detect CD13+, CD33+, CD15+ and CD14+ antigens on the membrane surfaces of myeloid cells in the bone marrow from 51 MDS, 21 aplastic anemia (AA), 21 paroxysmal nocturnal hemoglobinuria (PNH) patients. 10 acute myeloblastic leukemia (AML) patients and 15 normal subjects by immunoenzymatic assay. The morphology and chromosome karyotype of bone marrow cells of MDS patients were also examined. RESULTS: CD14+, CD13+ and CD33+ cells in the bone marrow were more in MDS patients than in normal controls, AA patients and PNH patients. CD15+ cells in the bone marrow were less in MDS patients than in normal controls. CONCLUSIONS: The percentages of CD14+, CD13+ and CD33+ positive cells in the bone marrow of MDS patients were related to the percentage of myeloblasts, the chromosomal aberrations and the response to treatment. It indicated that there is immunophenotypic misexpression of myeloid cells in MDS patients. Immunophenotype analysis of myeloid cells might be useful for the diagnosis and treatment of MDS patients.  (+info)

The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements. (3/485)

BACKGROUND AND OBJECTIVE: Rapid identification of AML patients carrying the t(15;17) translocation for treatment decision-making is currently made on the basis of morphologic screening. However, the existence of both false positives and negatives highlights the need for more objective methods of screening AML cases and further molecular confirmation of the t(15;17) translocation. DESIGN AND METHODS: In the present study we analyzed a total of 111 AML cases in order to investigate whether immunophenotyping based on the assessment of multiple-stainings analyzed at flow cytometry could improve the sensitivity and specificity of morphologic identification of acute promyelocytic leukemia (APL) carrying the t(15;17) translocation. FISH analysis was used as a complementary technique for cases in which morphology and molecular biology yielded discrepant results. RESULTS: Concordant results between morphology and RT-PCR were found in 102/111 (91.8%) cases: 34 patients had M3/PML-RARalpha+ and 68 non-M3/PML-RARalpha- disease. Nine cases showed discrepants results. Multivariate analysis showed that the best combination of immunologic markers for discriminating between M3/PML-RARalpha+ and non-M3/PML-RARalpha- cases was that of the presence of heterogeneous expression of CD13, the existence of a single major blast cell population, and a characteristic CD34/CD15 phenotypic pattern (p<0.02). A score system based on these parameters was designed, and the 34 M3/PML-RARalpha+ cases showed a score of 3 (presence of the 3 phenotypic characteristics). In contrast, only 1 out of the 68 (1.3%) non-M3/PML-RARalpha- cases had this score, most o these latter cases (53/68, 78%) scoring either 0 or 1. Therefore, among these cases, immunophenotyping showed a sensitivity of 100% and a specificity of 99% for predicting PML/RARalpha gene rearrangements. Of the 9 cases in which morphology and molecular biology results were discrepant, four cases displayed M3 morphology without PML/RARalpha rearrangements by RT-PCR. In only one of these 4 cases did the immunophenotype score 3, this being the only FISH positive case. From the remaining five discrepant cases (non-M3 morphology while positive for PML/RARalpha) two cases had a phenotypic score of 3 and were FISH positive while the other three were negative by FISH. Upon repeating RT-PCR studies, two of these latter three cases became negative. INTERPRETATION AND CONCLUSIONS: Our results show that immunophenotyping may be of great value for quick screening of APL with PML/RARalpha rearrangements.  (+info)

Dissociation between growth arrest and differentiation in Caco-2 subclone expressing high levels of sucrase. (4/485)

Growth arrest and cell differentiation are generally considered temporally and functionally linked phenomena in small intestinal crypt cells and colon tumor cell lines (Caco-2, HT-29). We have derived a Caco-2 subclone (NGI3) that deviates from such a paradigm. In striking contrast with the parental cells, proliferative and subconfluent NGI3 cells were found to express sucrase-isomaltase (SI) mRNA and to synthesize relatively high levels of SI, dipeptidyl peptidase IV, and aminopeptidase N (APN). In postconfluent cells, little difference was seen in SI mRNA levels between Caco-2 and NGI3 cells, but the latter still expressed much higher levels of SI that could be attributed to higher rates of translation. APN expression was also greatly enhanced in NGI3 cells. To determine whether high levels of brush-border enzymes correlated with expression of cell-cycle regulatory proteins, we investigated their relative cellular levels in growing and growth-arrested cells. The results showed that the cyclin-dependent kinase inhibitors (p21 and p27) and D-type cyclins (D1 and D3) were all induced in postconfluent cells, but NGI3 cells expressed much higher levels of p21. This study demonstrated that cell growth and expression of differentiated traits are not mutually exclusive in intestinal epithelial cells and provided evidence indicating that posttranscriptional events play an important role in regulation of SI expression.  (+info)

Temporal association of the N- and O-linked glycosylation events and their implication in the polarized sorting of intestinal brush border sucrase-isomaltase, aminopeptidase N, and dipeptidyl peptidase IV. (5/485)

The temporal association between O-glycosylation and processing of N-linked glycans in the Golgi apparatus as well as the implication of these events in the polarized sorting of three brush border proteins has been the subject of the current investigation. O-Glycosylation of pro-sucrase-isomaltase (pro-SI), aminopeptidase N (ApN), and dipeptidyl peptidase IV (DPPIV) is drastically reduced when processing of the mannose-rich N-linked glycans is blocked by deoxymannojirimycin, an inhibitor of the Golgi-located mannosidase I. By contrast, O-glycosylation is not affected in the presence of swainsonine, an inhibitor of Golgi mannosidase II. The results indicate that removal of the outermost mannose residues by mannosidase I from the mannose-rich N-linked glycans is required before O-glycosylation can ensue. On the other hand, subsequent mannose residues in the core chain impose no sterical constraints on the progression of O-glycosylation. Reduction or modification of N- and O-glycosylation do not affect the transport of pro-SI, ApN, or DPPIV to the cell surface per se. However, the polarized sorting of two of these proteins, pro-SI and DPPIV, to the apical membrane is substantially altered when O-glycans are not completely processed, while the sorting of ApN is not affected. The processing of N-linked glycans, on the other hand, has no influence on sorting of all three proteins. The results indicate that O-linked carbohydrates are at least a part of the sorting mechanism of pro-SI and DPPIV. The sorting of ApN implicates neither O-linked nor N-linked glycans and is driven most likely by carbohydrate-independent mechanisms.  (+info)

Purification, characterization, gene cloning, sequencing, and overexpression of aminopeptidase N from Streptococcus thermophilus A. (6/485)

The general aminopeptidase PepN from Streptococcus thermophilus A was purified to protein homogeneity by hydroxyapatite, anion-exchange, and gel filtration chromatographies. The PepN enzyme was estimated to be a monomer of 95 kDa, with maximal activity on N-Lys-7-amino-4-methylcoumarin at pH 7 and 37 degrees C. It was strongly inhibited by metal chelating agents, suggesting that it is a metallopeptidase. The activity was greatly restored by the bivalent cations Co2+, Zn2+, and Mn2+. Except for proline, glycine, and acidic amino acid residues, PepN has a broad specificity on the N-terminal amino acid of small peptides, but no significant endopeptidase activity has been detected. The N-terminal and short internal amino acid sequences of purified PepN were determined. By using synthetic primers and a battery of PCR techniques, the pepN gene was amplified, subcloned, and further sequenced, revealing an open reading frame of 2,541 nucleotides encoding a protein of 847 amino acids with a molecular weight of 96,252. Amino acid sequence analysis of the pepN gene translation product shows high homology with other PepN enzymes from lactic acid bacteria and exhibits the signature sequence of the zinc metallopeptidase family. The pepN gene was cloned in a T7 promoter-based expression plasmid and the 452-fold overproduced PepN enzyme was purified to homogeneity from the periplasmic extract of the host Escherichia coli strain. The overproduced enzyme showed the same catalytic characteristics as the wild-type enzyme.  (+info)

Quantification of conversion and degradation of circulating angiotensin in rats. (7/485)

The aim of the present study was to quantify with a uniform technique the rates of conversion of ANG I to ANG II in the lung and kidney and the degradation of both peptides to biologically inactive products in the pulmonary, renal, and systemic circulation. We infused the peptides intravenously, into the left ventricle, and into the left renal artery of rats and compared their effects on renal blood flow. The measured change in renal blood flow was used as a bioassay parameter to estimate the concentration of circulating ANG II. Mathematical analysis of our data allowed us to calculate conversion and degradation rates. Furthermore, the role of aminopeptidases A (EC 3.4.11.7) and N (EC 3.4.11.2) in the degradation of the peptides in the kidney was investigated by intrarenal infusion of the inhibitor amastatin. Our results show that the conversion rate of ANG I is 75% in the pulmonary and 21% in the renal circulation. Both peptides are degraded by 5% in the pulmonary, by 67% in the systemic, and by 93% in the renal circulation. Amastatin prevented 60% of the renal degradation of the peptides to inactive products, and this effect could be attributed to inhibition of aminopeptidase N. The results indicate that the converting capacity of the kidney is of minor importance for endocrine generation of ANG II but could be useful for the paracrine production.  (+info)

Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). (8/485)

Human mast cells are known to arise from a CD34(+)/c-kit(+) progenitor cell population that also gives rise to neutrophils, eosinophils, basophils, and monocytes. To further characterize cells within the CD34(+)/c-kit(+) population that yield mast cells, this progenitor was additionally sorted for CD13, a myeloid marker known to appear early on rodent mast cells and cultured human mast cells, but not expressed or expressed at low levels on human tissue mast cells; and cultured in recombinant human (rh) stem cell factor (rhSCF), rh interleukin-3 (rhIL-3; first week only), and rhIL-6. Initial sorts revealed that although the majority of cells in culture arose from the CD34(+)/c-kit(+)/CD13(-) cell population, mast cells arose from a CD34(+)/c-kit(+)/CD13(+) progenitor cell that also gave rise to a population of monocytes. Sequential sorting confirmed that CD34(+)/c-kit(+)/CD13(+) cells in CD34(+)/c-kit(+)/CD13(-) sorts gave rise to the few mast cells observed in CD13(-) sorted cells. CD34(+)/c-kit(+)/CD13(+) cells plated as single cells in the presence of various cytokine combinations gave rise to pure mast cell, monocyte, or mixed mast cell/monocyte progeny. Addition of either rh granulocyte-macrophage colony-stimulating factor (rhGM-CSF) or rhIL-5 to the CD34(+)/c-kit(+)/CD13(+) progenitor cell population cultured in rhSCF, rhIL-3, and rhIL-6 did increase the number of total cells cultured and in the case of rhIL-5, did increase total mast cell numbers. Neither rhGM-CSF or rhIL-5 led to additional cell populations, ie, even with the addition of rhGM-CSF or rhIL-5, only mast cells and monocytes grew from CD34(+)/c-kit(+)/CD13(+) cells. Thus, human mast cells and a population of monocytes arise from precursor cells that express CD34, c-kit, and CD13; and within which, are mast cell, monocyte, and mast/monocyte (bipotential) precursors.  (+info)

In this study, we determined serum aminopeptidase N/CD13 concentrations in patients with NSCLC using an aminopeptidase N/CD13-specific mAb (MH8-11), which inhibits cell motility and angiogenesis in vitro (10). Serum aminopeptidase N/CD13 concentrations were significantly elevated in patients with advanced-stage NSCLC. When the serum aminopeptidase N/CD13 values corresponding to the best diagnostic accuracy to separate the healthy controls and the patients with NSCLC were used as the cutoff value, the sensitivity of aminopeptidase N/CD13 was poorer than that of serum carcinoembryonic antigen; this suggests that serum aminopeptidase N/CD13 is not valuable as a diagnostic marker. However, a high serum aminopeptidase N/CD13 was significantly associated with established adverse prognostic factors in NSCLC, such as advanced stage, poor performance status, and poor response to chemotherapy. Serum aminopeptidase N/CD13 levels were also associated with overall survival in univariate analyses and had an ...
HUMAN coronaviruses (HCV) in two serogroups represented by HCV-229E and HCV-OC43 are an important cause of upper respiratory tract infections1. Here we report that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells2-5, is a receptor for human coronavirus strain HCV-229E, but not for HCV-OC43. A monoclonal antibody, RBS, blocked HCV-229E virus infection of human lung fibroblasts, immunoprecipitated aminopeptidase N and inhibited its enzymatic activity. HCV-229E-resistant murine fibroblasts became susceptible after transfection with complementary DNA encoding human aminopeptidase N. By contrast, infection of human cells with HCV-OC43 was not inhibited by antibody RBS and expression of aminopeptidase N did not enhance HCV-OC43 replication in mouse cells. A mutant aminopeptidase lacking the catalytic site of the enzyme did not bind HCV-229E or RBS and did not render murine cells susceptible to HCV-229E infection, suggesting that the virus-binding site may
Aminopeptidase N (Myeloid Plasma Membrane Glycoprotein CD13 or Alanyl Aminopeptidase or Aminopeptidase M or Microsomal Aminopeptidase or gp150 or CD13 or ANPEP or EC 3.4.11.2) - Market research report and industry analysis - 11296626
Aminopeptidase N (APN)/CD13 as ubiquitously expressed membrane peptidase exerts important functions in diverse cellular processes, such as proliferation, migration and differentiation. Previously, a role of APN in the invasiveness of melanoma cells has been demonstrated, but the underlying molecular mechanisms controlling APN expression are not understood. The present study demonstrates that lack of APN expression in primary and established melanoma cells was directly associated with a high-grade DNA methylation status of the myeloid APN promoter. Demethylation by 5-aza-2-desoxycytidine not only induced constitutive and cytokine-regulated APN protein expression but also resulted in an increased APN-dependent migration of melanoma cells. Furthermore, its heterogeneous expression was inversely correlated to the expression of melanocytic marker proteins in established as well as in short-term cultured human melanoma cells. Staining of tissue microarrays generated from a large series of melanoma ...
Mouse Monoclonal Anti-Aminopeptidase N/CD13 Antibody (CC81) [DyLight 488]. Validated: Flow. Tested Reactivity: Bovine. 100% Guaranteed.
Membrane alanyl aminopeptidase (EC 3.4.11.2) also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, ...
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract ...
The IUPHAR/BPS Guide to Pharmacology. Leucyl-cysteinyl aminopeptidase - M1: Aminopeptidase N. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
CD13/aminopeptidase N (APN), which is a zinc-dependent metalloproteinase, plays a vital role in the growth, migration, angiogenesis, and metastasis of tumours. Thus, in situ molecular imaging of endogenous APN levels is considerably significant for investigating APN and its different functions. In this study 2018 Chemical Science HOT Article Collection
Studies have come to conflicting conclusions about whether adiponectin (APN) expression is associated with cancer prognosis. To help resolve this question, we meta-analyzed the available evidence. PubMed, EMBASE, the Cochrane Library, the Chinese Biological Medical Database and the Chinese National Knowledge Infrastructure Database were systematically searched to identify all eligible studies examining APN expression and prognosis for patients with any type of cancer. Pooled hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) related to overall survival (OS) or disease-free survival (DFS) were calculated. Ten studies involving 999 patients were meta-analyzed. Analysis across all patients revealed no significant association between high/positive APN expression and DFS, but they did show a significant association between high/positive APN expression and OS (HR 1.51, 95 %CI 1.21 to 1.89). Subgroup analysis showed that high/positive APN expression in non-Asians was significantly associated
The invention relates to the use of inhibitors of dipeptidyl peptidase IV DP IV and enzymes having the same specific nature of substrate DP IV enzyme activitycombined with inhibitors of alanyl aminopeptidase aminopeptidase N, APNor enzymes having the same specific nature of substrate APN enzyme Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.. Combined use of enzyme inhibitors for the treatment and prevention of allergic reactions of type i according to the gell and coombs classification, and for the treatment and prevention of dermatological diseases associated with follicular kostengünstige Sprays bei Psoriasis epidermal hyperkeratosis and reinforced keratinocyte proliferation EP B1. The invention kostengünstige Sprays bei Psoriasis to the use of inhibitors of dipeptidyl peptidase IV DP IV and enzymes having the same specific nature of substrate DP IV enzyme activitycombined with inhibitors of alanyl aminopeptidase ...
Anpep - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN301326G1|/strong|, Anpep gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
Aminopeptidase with broad substrate specificity to several peptides. Shows strong preference for leucine but cleaves also next to Arg and lysine in peptide-bond-containing substrates.
To determine the primary structure of CD13, a 150-kD cell surface glycoprotein originally identified on subsets of normal and malignant human myeloid cells, we isolated the complete sequences encoding the polypeptide in overlapping complementary DNA (cDNA) clones. The authenticity of our cDNA clones …
The graphic displays domains and Protease cut sites on the protein sequence. Drag your mouse right/left over the graphic. Use the selection boxes on the right to select which annotations to view simultaneously. Combine annotation with multiple checkmarks.. ...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Summary The pepN gene has been cloned into the multicopy plasmid pBR322. The restriction map of the insert was established and the gene was localized. By comparison with the restriction map of the plasmid pJP30 bearing the ompF region, it has been possible to order the ompF, asnS, and pepN genes.... mehr ...
In addition to their well characterized effects at dopamine receptors, neuroleptic drugs have been shown to affect the level and in vitro metabolism of neuropeptides. In the present study, the effect of acute and subchronic administration of the neuroleptic haloperidol and the nonselective, dopamine agonist apomorphine on neuropeptidase activity was determined in regional, rat brain P2 membranes. Subchronic administration of haloperidol decreased the activity of aminopeptidase N in the frontal cortex and caudate-putamen. In contrast, subchronic administration of apomorphine increased aminopeptidase N activity in the frontal cortex and caudate-putamen. Neutral endopeptidase 24.11 also was affected differentially in the caudate-putamen, but both subchronic haloperidol and apomorphine decreased neutral endopeptidase 24.11 activity in the frontal cortex. Metalloendopeptidase 24.15 activity was decreased in the caudate-putamen after acute haloperidol and increased in the frontal cortex after acute ...
F4⁺ enterotoxigenic Escherichia coli (ETEC) strains cause diarrheal disease in neonatal and post-weaned piglets. Several different host receptors for F4 fimbriae have been described, with porcine aminopeptidase N (APN) reported most recently. The FaeG subunit is essential for the binding of the three F4 variants to host cells. Here we show in both yeast two-hybrid and pulldown assays that APN bind ...
Zhao M, Yuan X, Wei J, et al. Functional Roles Of Cadherin, Aminopeptidase-N And Alkaline Phosphatase From Helicoverpa Armigera (Hübner) In The Action Mechanism Of Bacillus Thuringiensis Cry2Aa[J]. Scientific Reports, 2017.
Acétylmuramyl Alanyl Isoglutamine; acetylmuramyl alanyl isoglutamine; alanyl isoglutamine, acetylmuramyl; dipeptide, muramyl; isoglutamine, acetylmuramyl alanyl; mur nac l ala d isogln; muramyl dipeptide; mur-nac-l-ala-d-isogln; n acetyl muramyl l alanyl d glutamic alpha amide; n acetylmuramyl l alanyl d isoglutamine; n-acetyl-muramyl-l-alanyl-d-glutamic-alpha-amide; n-acetylmuramyl-l-alanyl-d-isoglutamine. Aide pour diagnostic médical. Méthode automatique dassociations de symptômes pour classifier les plus de 4.000 maladies en quatre langues différentes
The objective of this study was to determine rabbit seminal plasma enzyme activity. Furthermore, correlations between semen parameters and enzyme activity and male age were examined. The study was performed using 17 New Zealand White males from 5 to 9 mo old. Overall, 252 semen samples were collected from bucks from May to September. Semen characteristics were analysed and the seminal plasma was obtained by centrifugation. The activities of alanyl aminopeptidase (APN), aspartate transaminase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GOT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALKP) in the seminal plasma fluid were measured. Significant differences between males were found in APN, GGT, LDH, ALKP and ALT activities (P<0.05). No significant differences between enzyme activity and male age were found. We also observed significant positive correlations between male age and sperm concentration (r=0.26), progressive motility (r=0.17) and amplitude of ...
Melflufen (melphalan flufenamide, previously designated J1) is an anticancer drug under development by Oncopeptides AB. It is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis. Currently, melflufen is under evaluation in a multinational and randomized phase III study for the treatment of patients with relapsed and refractory multiple myeloma. Melflufen is metabolized by aminopeptidase hydrolysis and by spontaneous hydrolyisis on N-mustard. Its biological half-life is 10 minutes in vitro. Melflufen is a peptidase enhanced cytotoxic (PEnC) with a targeted delivery within tumor cells of melphalan, a widely used classical chemotherapeutic belonging to a group of alkylating agents developed more than 50 years ago. Substantial clinical experience has been ...
The co-distribution of SFN with APN at the leading edge of fibroblasts was unpredicted. Interestingly, an in vitro wound scratch assay revealed higher expression of APN within the migratory fibroblasts, where it co-distributed with vinculin, a migration marker (Lai et al., 2010). In addition, the inhibition of cell migration by reducing or blocking APN levels in tumor cells, lymphocytes and endothelial cells has also been reported (Terauchi et al., 2007; Proost et al., 2007). Therefore, the higher expression of APN receptor at the leading edge of migratory cells could explain the enhanced co-distribution results observed with biotin-SFN. Furthermore, the movement of cells through ECM is highly dependent on the activity of proteases such as MMPs (Gianneli et al., 1997; Kessenbrock et al., 2010; Pilcher et al., 1997; Pirila et al., 2003). This raises the possibility that SFN interaction with APN and the subsequent increase in MMP-1 activity could play a role in the cell migration of ...
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
CHAPTER LXXVIII. 203 Jh 4^ !j3 .2-^ aS-: 04g what mon fal ames vish ^ 0 w CD -^ a-c i^, w-w Uesckiption of the Single VISHTIS. -c; .£ Ti fO N CD o3 rc; ■^ t+H 0 c3 f,, A cS ^ OJ -C 4J Pi 1-1 It is white, has three eyes, and rides on an elephant, which always remains the same. In the one hand he has a huge rock, in the other a vajra of iron, which it throws. It destroys the cattle over which it rises. He who makes war coming from the direction whence it rises will be victorious. A man must not turn with his face towards it when tearing out fattening herbs, digging out treasures, and trying to satisfy the wants of life. It has the colour of crystal. In one hand it holds a three¬ fold parasvadha, and in the other a rosary. It looks towards heaven, and saj^s hd hd hd. It rides on an ox. Its time is favourable for handing over the chil¬ dren to the schools, for con¬ cluding peace, giving alms, and works of piety. ■Sg2 si osq It is pistachio-coloured like a parrot. It looks like ...
Aerobic activity іѕ аnу activity thаt requires сlеаn air tο produce thе nесеѕѕаrу ATP (adenosine triphosphate) tο carry out thе activity. Aerobic work out activity gets ATP through thе Krebs Design. Once through thе Krebs pattern generates 36 ATPs compared tο јυѕt 2 ATP through glycolysis οr anaerobic pattern. Aerobic work out activity іѕ essential fοr уουr center health.. Aerobic activity achieves thе following:. 1. Increases уουr VO2 max (уουr maximum сlеаn air uptake). It dοеѕ thіѕ bу helping thе quality οf сlеаn air уουr human іѕ аblе tο υѕе during regular aerobic work out activities. If уουre out οf shape аnd rυn a range, уου mіght rυn іt іn ten minutes οr ѕο, bυt іf уου hаνе a regular aerobic workout routine (whісh сουld involve operating, walking, managing, driving, οr аnу center activity), уου саn speed up managing thе range bу minutes bесаυѕе уουll bе breathing more ...
CD13, also known as aminopeptidase N, APN and gp150, is a 150-170 kDa transmembrane ectoenzyme occurring on monocytes and granulocytes but not lymphocytes in blood.
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
A story: In the mid-1990s, I participated inside a PSA guideline group for Malignancy Care Ontario. The usual literature search was carried out, which focused on the evidence of mortality benefit and the potential harms of screening. I have been building decision types of PSA testing2 and measuring quality-of-life and price results for a long time. I was somewhat chagrined that non-e of my documents resulted in in the search. I had been created by it question, So why will be the remaining committee and We viewing this nagging issue thus differently? My model recommended that there could be a mortality advantage but general a lack of quality-adjusted life span. This meant that the true manner in which patients valued health outcomes was an integral area of the testing decision. Quite simply, this is a preference-sensitive decision. Furthermore, it seemed as well obvious to say that price was another concern Mouse monoclonal to CD13.COB10 reacts with CD13, 150 kDa aminopeptidase N (APN). CD13 is ...
Opiorfin je endogeno hemijsko jedinjenje koje je prvo izolovano iz ljudske pljuvačke. Inicijalna istraživanja na miševima su pokazala da ovo jedinjenje ima veći analgetski efekat od morfina. Opiorfin deluje putem zaustavljanja normalnog razlaganja prirodnih analgetskih opioida u kičmenoj moždini, zvanih enkefalini. On je relativno mali peptid koji se sastoji od pet aminokiselina: Gln-Arg-Phe-Ser-Arg.[1][2][3][4][5][6][7][8] Opiorfin pentapetid potiče od N-terminalnog regiona proteina PROL1 (prolinom bogat, lakrimal 1).[1] Opiorfin inhibira dve proteaze: neutralnu ekto-endopeptidazu (MME) i ekto-aminopeptidazu N (ANPEP).[1] ...
Looking for SPECTRUM Dl Alanyl Dl Methionine,100mg (26WF72)? Graingers got your back. Price:$55.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
3-Fluoro-DL-tyrosine can be used to study how halogenated tyrosines affect proteins such as bacteriorhodopsin, microvillar enzymes, and β-galactosidases.
The pig intestinal brush border enzymes aminopeptidase N (EC 3.4.11.2) and lactase-phlorizin hydrolase (EC 3.2.1.23-62) are present in the microvillar membrane as homodimers. Dimethyl adipimidate was used to cross-link the two [35S]methionine-labeled brush border enzymes from cultured mucosal explants. For aminopeptidase N, dimerization did not begin until 5-10 min after synthesis, and maximal dimerization by cross-linking of the transient form of the enzyme required 1 h, whereas the mature form of aminopeptidase N cross-linked with unchanged efficiency from 45 min to 3 h of labeling. Formation of dimers of this enzyme therefore occurs prior to the Golgi-associated processing, and the slow rate of dimerization may be the rate-limiting step in the transport from the endoplasmic reticulum to the Golgi complex. For lactase-phlorizin hydrolase, the posttranslational processing includes a proteolytic cleavage of its high molecular weight precursor. Since only the mature form and not the precursor of this
Porcine deltacoronavirus (PDCoV), can be an emerging enteropathogenic coronavirus in pigs, that poses a novel threat to swine husbandry worldwide. contamination (Godet et al., 1994) and in severe acute respiratory syndrome coronavirus (SARS-CoV) in the genus (Li et al., 2005). In contrast, the RBD regions of murine hepatitis computer virus and bovine coronavirus, both in the genus are located in the N-terminus of the S1 domain name (Peng et al., 2011, 2012). However, the immunodominant neutralizing region associated with delta-CoVs, such as PDCoV, has not been identified. Recent elucidation of PDCoV spike protein structures by cryo-electron microscopy reveal that this S1 subunit consists of four independently folded domains, specified A, B, C, and D (Xiong et al., 2018). Lately, Li et al. (Li et al., 2018) confirmed the fact that porcine aminopeptidase N, previously regarded as an operating receptor for transmissible gastroenteritis pathogen (TGEV), also interacts using the B area of PDCoV S1 ...
The property of solutions of Triton X-114 to separate into detergent-rich and detergent-poor phases at 30 degrees C has been exploited to investigate the identities of the aminopeptidases in synaptic membrane preparations from pig striatum. When titrated with an antiserum to aminopeptidase N (EC 3.4.11.2), synaptic membranes solubilized with Triton X-100 revealed that this enzyme apparently comprises no more than 5% of the activity releasing tyrosine from [Leu]enkephalin. When assayed in the presence of puromycin, this proportion increased to 20%. Three integral membrane proteins were fractionated by phase separation in Triton X-114. Aminopeptidase activity, endopeptidase-24.11 and peptidyl dipeptidase A partitioned predominantly into the detergent-rich phase when kidney microvillar membranes were so treated. However, only 5.5% of synaptic membrane aminopeptidase activity partitioned into this phase, although the other peptidases behaved predictably. About half of the aminopeptidase activity in ...
To analyze the influence of cell differentiation and the effects of hormones on the subcellular distribution of apical antigens in polarized epithelial cells, we have compared the localization of three brush border (BB) hydrolases [neutral endopeptidase (ENDO), aminopeptidase N (APN), and dipeptidyl …
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The E-Lib is a centralized database of information on APN projects and related outputs. It contains metadata and outputs of all completed and ongoing APN projects since 1998, as well as APN publications such as the Science Bulletin, books, proceedings, reports and policy briefs, etc.
If you are interested in phonographs, gramophones and the history of recorded sound, then the Canadian Antique Phonograph Society (CAPS) is for you. This site provides a glimpse of the Societys programs and activities, and highlights from its bi-monthly publication Antique Phonograph News (APN).
The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016 ...
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Analysis of Antimalarial Synergy between Bestatin and Endoprotease Inhibitors Using Statistical Response-Surface Modelling: The pathway of hemoglobin degradatio
Pelatihan PONEK - Pelatihan FKTP - Pelatihan MFK - Pelatihan PPGDON - Pelatihan APN - Pelatihan IPCN - Pelatihan Geriatri - Pelatihan Asesor - Pelatihan Case Manajer - Pelatihan Clinical Pathway. Pelatihan PONEK 2020, Pelatihan PONED 2020, Pelatihan Keperawatan 2020, Pelatihan Asesor Perawat, Pelatihan Asesor Bidan, Pelatihan Geriatri 2020, Pelatihan PPI 2020, Pelatihan IPCD 2020, Pelatihan MFK, Pelatihan Asesor Keperawatan, Pelatihan Asesor Bidan 2020, Pelatihan Geriatri, Pelatihan PPI, Pelatihan IPCD, Pelatihan IPCN, Pelatihan Humas Dan Marekting Rumah Sakit, Pelatihan ANJAB, Pelatihan PMKP, Pelatihan HIV Dan AIDS, Pelatihan FKTP, Pelatihan EWS, Pelatihan IPAL, Pelatihan, Pelatihan Kredensial Rumah Sakit, Pelatihan Case Manager, Pelatihan Clinical Pathway, Pelatihan Arsip Elektronik Rumah Sakit, Pelatihan Arsip Elektronik Pemda, Pelatihan Gerontik, Pelatihan APN, Pelatihan HDP, Pelatihan K3 Rumah Sakit, Pelatihan Koding, Pelatihan Gizi Rumah Sakit, Pelatihan Kepala Bidang Keperawatan, ...
Pelatihan PONEK - Pelatihan FKTP - Pelatihan MFK - Pelatihan PPGDON - Pelatihan APN - Pelatihan IPCN - Pelatihan Geriatri - Pelatihan Asesor - Pelatihan Case Manajer - Pelatihan Clinical Pathway. Pelatihan PONEK 2020, Pelatihan PONED 2020, Pelatihan Keperawatan 2020, Pelatihan Asesor Perawat, Pelatihan Asesor Bidan, Pelatihan Geriatri 2020, Pelatihan PPI 2020, Pelatihan IPCD 2020, Pelatihan MFK, Pelatihan Asesor Keperawatan, Pelatihan Asesor Bidan 2020, Pelatihan Geriatri, Pelatihan PPI, Pelatihan IPCD, Pelatihan IPCN, Pelatihan Humas Dan Marekting Rumah Sakit, Pelatihan ANJAB, Pelatihan PMKP, Pelatihan HIV Dan AIDS, Pelatihan FKTP, Pelatihan EWS, Pelatihan IPAL, Pelatihan, Pelatihan Kredensial Rumah Sakit, Pelatihan Case Manager, Pelatihan Clinical Pathway, Pelatihan Arsip Elektronik Rumah Sakit, Pelatihan Arsip Elektronik Pemda, Pelatihan Gerontik, Pelatihan APN, Pelatihan HDP, Pelatihan K3 Rumah Sakit, Pelatihan Koding, Pelatihan Gizi Rumah Sakit, Pelatihan Kepala Bidang Keperawatan, ...
Definition of leucine aminopeptidase in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is leucine aminopeptidase? Meaning of leucine aminopeptidase as a legal term. What does leucine aminopeptidase mean in law?
These studies demonstrate that RI Ang II, an AT2R ligand, does not induce a natriuresis in the presence of systemic AT1R blockade. However, a natriuretic response to Ang II, mediated by the AT2R, is unmasked by the intrarenal addition of PC-18, an APN inhibitor. Because the metabolism of Ang III to Ang IV by APN is inhibited by PC-18, these data suggest that Ang III is a significant mediator of Ang II-induced natriuresis. This conclusion is further supported by the ability of APA inhibition to abolish the natriuretic response to Ang II+PC-18.. Previous studies from our laboratory have shown that in the presence of AT1R blockade, RI Ang III infusion results in natriuresis that is abolished by concomitant PD infusion, implicating the renal AT2R in the response.21 Furthermore, addition of RI PC-18 to Ang III infusion causes a 1.8- to 2.8-fold increase in Na+ excretion compared with RI Ang III infusion alone.22 These findings prompted the present set of investigations to determine whether renal ...
Compare arginyl aminopeptidase (aminopeptidase B)-like 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Según nota de diarios argentinos, el pais gaucho gastó el 2003 : 22 millones de dólares en vacunar a 28 millones de argentinos, algo que a la periodista cientifica argentina: Nora Bär (autora de la nota), le pareció excesivo, razón por la cual instaba a la industria argentina a relanzar su primigenio programa de autoabastecimiento de vacunas. La Bär, no solo estaba preocupada por los altos costos, sino también por la eficacia, habida cuenta que cepas antigenicas no argentinas, no siempre proporcionarian protección, al 100%. El hecho importa porque el MINSA (Ministerio de Salud del Perú), acaba de gastar 22 millones de dólares en una Campaña Nacional de Vacunación contra el Sarampión, la Rubéola y el Síndrome de Rubéola Congénita -01/10/06-05/11/06-), en un universo de apenas 14 millones de peruanos -hombres y mujeres -entre 02- 39 años-. Para el MINSA, la actividad, buscó cumplir con la Resolución CD 44-R1 de la OPS (Organización Panamericana de la Salud) y OMS ...
The Institute for Latino Studies (ILS) at the University of Notre Dame is pleased to announce our annual Young Scholars Symposium. Our visiting professor for this academic year is Professor José E. Limón, Notre Dame Foundation Professor of American Literature Emeritus at the University of Notre Dame, Mody C. Boatright Regents Professor of American Literature Emeritus University of Texas at Austin, and former Director of the Institute for Latino Studies.. Professor José E. Limóns activities on the Notre Dame campus will include a symposium for advanced doctoral students and pre-tenured professors. We seek applications from young scholars who are working on a dissertation, a book, or another research project related to the study of U.S. Latina and Latino populations. Successful nominees will attend Professor José E. Limóns public lecture and participate in a symposium at which they will present a dissertation chapter or essay draft for discussion with Professor José E. Limón and ILS ...
Malarial aminopeptidase molecule. Computer model showing the structure of the M18 aspartyl aminopeptidase with a dodecameric assembly arranged via dimer and trimer units forming a tetrahedron shape. From Plasmodium falciparum. - Stock Image C035/8499
Other causes of acute pancreatitis such as drugs, trauma and hypotension were excluded, and the patient was discharged after 35 days of hospitalization without any long-term sequelae.. Discussion. Initially reported as a respiratory tract pathogen, SARS-CoV-2 has been identified in many other tissues, such as the cardiovascular, renal and gastrointestinal tract, similar to SARS-CoV in 2003.5,6 Both viruses have ACE2 as the functional host cell receptor, enabling virus entry and replication.1,5,7 However, different from SARS-CoV, SARSCoV-2 does not use other receptors such as aminopeptidase N and dipeptidyl peptidase 4,8 being more selective. Furthermore, SARS-CoV-2 has higher affinity to ACE2 when compared to SARS-CoV, being more pathogenic5 and increasing the ability of community transmission.9. ACE2 is abundantly expressed in many different tissues, justifying the involvement of different organs and extrapulmonary symptoms of those diseases.1,5,7 The expression of ACE2 in the gastrointestinal ...
since using bestatin, i cough a lot more and when in bed i feel some irragular heartbeat. somewhere ... which were nog good. so many bad side effects.
This chapter describes the approaches used to identify Gram-negative rods, with emphasis on the greater difficulty in identifying non-glucose-fermenting organisms. We amplify what was presented in the 9th edition of this Manual by presenting a scheme to identify these organisms that is centered around three enzymatic activities, i.e., oxidase, trypsin (benzyl-arginine arylamidase or benzyl-arginine aminopeptidase), and pyrrolidonyl aminopeptidase. These enzymatic reactions are fast and easy to interpret, and they are stable markers in almost all taxa discussed; i.e., there are few species for which these tests yield variable intraspecies results.
As of December 5, 2012, the USPTO had received 3rd Party Submissions in 111 pending applications. I have listed these here: APN 13057428 13145379 12829968 12940276 13036151 13409599 12832713 12914510 12940265 13367018 13403496 12793132 13133905 12027158 13146703 13284337 12901113 13276498 12949867 13030014 13061072 13238728 12911418 12987982 13308698 13465789 13270518 12708697 12980609 13198108 13205610 13370103 13330442 13331182 13331192 13027232 13370480 13458626 12896664 13072724 13212266 13214397 13331786 13062414 13444511 13460635 11946818 12890208 12890259 13061068 13062106 13316963 13325149 12882610 13143163 13193319 12908761 13129175 13281126 13179249 13328621 12946772 13052381 13401848 13039184 13280490 13354282 13354286 12950669 13043011 13052666 13214230 12731825 13101072 13280914 13280932 12899731 13280536 13331998 13354244 13354284 13354290 12899972 13280843 13413451 13536353 13196835 12856888 13092606 13305290 13064390 13281615 13487297 11883950 13486014 13016460 13126818 13161311 ...
Unlike myeloid dendritic cells, myeloid antigens like CD11b, CD11c, CD13, CD14 and CD33 are not present on pDC surfaces. ... In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2 ... Villadangos, José A.; Young, Louise (September 2008). "Antigen-Presentation Properties of Plasmacytoid Dendritic Cells". ... which allows the cell to optimize its antigen-presenting abilities. MHC class I on pDC surfaces are able to activate CD8+ T ...
Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 ... Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) ... This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. GRCh38: Ensembl release 89: ... "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". ...
... antigens, cd7 MeSH D23.050.301.264.894.108 - antigens, cd8 MeSH D23.050.301.264.894.113 - antigens, cd13 MeSH D23.050.301.264. ... antigens, cd13 MeSH D23.050.301.264.035.114 - antigens, cd14 MeSH D23.050.301.264.035.115 - antigens, cd15 MeSH D23.050.301.264 ... antigens, cd13 MeSH D23.101.100.110.114 - antigens, cd14 MeSH D23.101.100.110.115 - antigens, cd15 MeSH D23.101.100.110.118 - ... antigens, cd7 MeSH D23.101.100.894.108 - antigens, cd8 MeSH D23.101.100.894.113 - antigens, cd13 MeSH D23.101.100.894.118 - ...
White Cell Differentiation Antigens. Oxford University Press. Knapp, W; et al. (1989). Leucocyte Typing IV. Oxford University ... Antibodies CD71/Transferrin receptor-1 CD13 marker for kidney disorder CD33 marker for AML treatment CD4+/CD8+ ratio Immune ... "CD Antigens" (PDF). abcam. 2009. Retrieved 2014-11-22. Passlick B, Flieger D, Ziegler-Heitbrock HW (1989). "Identification and ... In the example of CD4 & CD8, these molecules are critical in antigen recognition. Others (e.g., CD135) act as cell surface ...
Recently, Heneberg proposed that basophils may be defined as the cellular population positive for CD13, CD44, CD54, CD63, CD69 ... pollen proteins or helminth antigens. Recent studies in mice suggest that basophils may also regulate the behavior of T cells ... When activated, some additional surface markers are known to be upregulated (CD13, CD107a, CD164), or surface-exposed (CD63, ...
CD13): Influence of N-Linked Glycosylation". Journal of Virology. 75 (20): 9741-52. doi:10.1128/JVI.75.20.9741-9752.2001. PMC ... There are also two different serotypes found with different antigens that produce unique antibodies. FCoV serotype I (also ...
"Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ...
In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell antigen interactions. ... This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen- ... Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex ...
... is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The ... Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, ... T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for antigens presented by MHC II and ... CD1+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ...
CD64+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem ... CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ... CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 ...
1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... 1992). "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse ... Kasinrerk W, Fiebiger E, Stefanová I, Baumruker T, Knapp W, Stockinger H (1992). "Human leukocyte activation antigen M6, a ... Ok blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ...
Tissue Antigens (англ.)русск. : journal. - 2007. - Vol. 68, no. 6. - P. 509-517. - DOI:10.1111/j.1399-0039.2006.00726.x. - PMID ...
3 (9): 1020-9. doi:10.1158/2159-8290.CD-13-0226. PMID 23779130. Litt JZ (25 January 2013). Litt's Drug Eruptions and Reactions ... including significantly greater relative decreases and increases in levels of prostate-specific antigen (PSA) and testosterone ...
CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens-associated invariant chainIa antigen ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ... Machamer C.E., Cresswell P. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens (англ.) // ...
In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.[5] CD44 has been referred to as HCAM (homing cell ... The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. ... Indian blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ... "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in ...
... uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate (англ.) // Blood (англ ...
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • ... CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... 2001). „Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same ... Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. (англ.) // Hum. ... Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3 ... Rose T. M., Plowman G. D., Teplow D. B., etal. Primary structure of the human melanoma-associated antigen p97 ( ...
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5. External IDs. HomoloGene: 128801 GeneCards: ... Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". ...
A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine. 176 (2): 327-37. doi:10.1084 ... antigen processing and presentation of exogenous peptide antigen via MHC class II. ... antigen binding. • transmembrane signaling receptor activity. • MHC class II protein binding. Cellular component. • membrane. • ...
van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ...
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • ... 1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID ... 2003). „Signal transduction-associated and cell activation-linked antigens expressed in human mast cells". Int. J. Hematol. 75 ...
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ...
B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In ... Grewal, IS; Xu, J; Flavell, RA (7 December 1995). "Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand". ...
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... results from cDNA cloning and sequence comparison of the CD30 antigen from different sources". Molecular Immunology. 31 (17): ...
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ... CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Eichler W, Hamann J, Aust G (Nov 1997). "Expression characteristics of the human CD97 antigen". Tissue Antigens. 50 (5): 429-38 ... Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP (Apr 1999). "Expression of the activation antigen CD97 and ... Tissue Antigens. 57 (4): 325-31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941.. ... "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes ... This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may ... dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens". J. Immunol. 167 (11): ...
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin ...
Macrophage-1 antigen (CD11b+CD18). *VLA-4 (CD49d+CD29). *Glycoprotein IIb/IIIa (ITGA2B+ITGB3) ...
"Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin". Molecular and ...
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • ... CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ... "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of ...
antigen processing and presentation of peptide antigen via MHC class I. • antigen processing and presentation of exogenous ... antigen processing and presentation of exogenous peptide antigen via MHC class I. • lipoprotein transport. • negative ... peptide antigen via MHC class I, TAP-dependent. • platelet degranulation. • MyD88-dependent toll-like receptor signaling ...
antigen binding. • virus receptor activity. • protein binding. • transmembrane signaling receptor activity. • identical protein ...
Recently, Heneberg[17] proposed that basophils may be defined as the cellular population positive for CD13, CD44, CD54, CD63, ... pollen proteins or helminth antigens. Recent studies in mice suggest that basophils may also regulate the behavior of T cells ... When activated, some additional surface markers are known to be upregulated (CD13, CD107a, CD164), or surface-exposed (CD63, ...
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. • T cell antigen ... CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c, d) · CD13 · CD14 · ...
Mouse Monoclonal Anti-Aminopeptidase N/CD13 Antibody (CC81) [DyLight 488]. Validated: Flow. Tested Reactivity: Bovine. 100% ... In cattle the antigen recognised by clone CC81 is primarily expressed on enterocytes and cells with a dendritic morphology in ... Additional Aminopeptidase N/CD13 Products. Aminopeptidase N/CD13 NB100-63392G * Aminopeptidase N/CD13 Antibodies ... Home » Aminopeptidase N/CD13 » Aminopeptidase N/CD13 Antibodies » Aminopeptidase N/CD13 Antibody (CC81) [DyLight 488] ...
Aminopeptidase N is identical to the myeloid differentiation antigen cluster of differentiation 13 (CD13). It is a zinc- ... The origin of circulating aminopeptidase N/CD13 is unclear at present. In our series, serum aminopeptidase N/CD13 levels were ... High levels of circulating aminopeptidase N/CD13 may, at least in part, reflect high levels of aminopeptidase N/CD13 expression ... Association of serum aminopeptidase N/CD13 level with clinicopathologic variables. A high serum aminopeptidase N/CD13 level was ...
Antigens. *Proteins & Growth Factors. *Control Peptides. *Synthetic Peptides. Lysates (see all»). *Lysates (Overexpressed) ... CD13 antibody. Quantity. 1 kit. Species (CRISPR). Mouse. Donor Vector. GFP-Puro. ...
Unlike myeloid dendritic cells, myeloid antigens like CD11b, CD11c, CD13, CD14 and CD33 are not present on pDC surfaces. ... In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2 ... Villadangos, José A.; Young, Louise (September 2008). "Antigen-Presentation Properties of Plasmacytoid Dendritic Cells". ... which allows the cell to optimize its antigen-presenting abilities. MHC class I on pDC surfaces are able to activate CD8+ T ...
Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 ... Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) ... This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. GRCh38: Ensembl release 89: ... "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". ...
Patients with null cell disease tended to be less than 2 years or greater than 10 years of age, and CD13 and CD33 positive. ... Antigens, CD / analysis * Antigens, Differentiation, Myelomonocytic / analysis * Antineoplastic Combined Chemotherapy Protocols ...
The CD13 antigen is a transmembrane glycoprotein with a large extracellular region and a small intracellular NH2-terminal tail ... CD13 Antibodies. The CD13 antigen is a transmembrane glycoprotein with a large extracellular region and a small intracellular ... There are up to five subpopulations of CD13 molecules possessing different levels of glycosylation, which may explain the ...
Acetylglucosaminidase, Adult, Aged, Alkaline Phosphatase, Alkynes, Aminopeptidases, CD13 Antigens, Creatinine, Diamines, Drug ...
CD and related antigens Blood group antigens Premixed antibody combinations Serum, plasma, and secreted proteins ...
... research reagents. CD300c Protein, Antibody, ELISA Kit, cDNA Clone. CD300c Proteins. CD300c ... The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and ... Tips: We list all the CD antigens according to the specific name of CD molecules.. *CD1b ...
Lifitegrast is a lymphocyte, function-associated antigen-1 antagonist. T4259. GLPG0187. GLPG0187, a broad spectrum integrin ... Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B. ... BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component ... BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component ...
Antigens, CD1. *Antigens, CD11. *Antigens, CD13. *Antigens, CD137. *Antigens, CD14. *Antigens, CD146 ...
In particular, several studies have reported the elevated expression of aminopeptidase N/CD13 in various cancers[35-38] and it ... Steinberg W: The clinical utility of the CA 19-9 tumor-associated antigen. Am J Gastroenterol. 1990, 85 (4): 350-355. ... Kehlen A, Lendeckel U, Dralle H, Langner J, Hoang-Vu C: Biological significance of aminopeptidase N/CD13 in thyroid carcinomas ... Serum carbohydrate antigen (CA19-9) has been extensively studied and is the most common tumour marker used in assisting in the ...
True-Nuclear™ Transcription Factor Buffer Set - for optimal staining of intranuclear and cytoplasmic antigens. Cytokine ... CD13. WM15. Yes. Lysed whole blood. View Products. CD14. M5E2. Yes. Lysed whole blood, monocytes. View Data. View Products. ... or other cytoplasmic antigens.. FluoroFix™ Buffer - for fixation of immunofluorescence stained cells, optimized to stabilize ... and relative abundance of the antigen. Costains are also recommended to help you identify your population of interest. If you ...
Telomere DNA content in prostate biopsies predicts early rise in prostate-specific antigen after radical prostatectomy for ... PMID: 23779129; DOI: 10.1158/2159-8290.CD-13-0135; * Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, ...
GW842166X HES7 HGF Imatinib KIAA1516 Lamivudine MK-4827 MMP7 MMP9 monocytes Mouse monoclonal to CD13.COB10 reacts with CD13 ... CD41 antigen acts as a receptor for fibrinogen fibrinectin and vitronectin and mediates platelet adhesion and aggregation. ... 135/120 kDa 150 kDa aminopeptidase N (APN). CD13 is expressed on the surface of early committed progenitors and mature ... chain response and western blotting had been utilized to detect the expression degrees of individual leukocyte antigen (HLA)-DR ...
GW842166X HES7 HGF Imatinib KIAA1516 Lamivudine MK-4827 MMP7 MMP9 monocytes Mouse monoclonal to CD13.COB10 reacts with CD13 ... CD41 antigen acts as a receptor for fibrinogen fibrinectin and vitronectin and mediates platelet adhesion and aggregation. ... 135/120 kDa 150 kDa aminopeptidase N (APN). CD13 is expressed on the surface of early committed progenitors and mature ... The amount of carcinoembryonic antigen (CEA) was regular, and abdominal CT demonstrated 1.7-cm wall thickening in the sigmoid ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA August 21, 2020. August 21, 2020. Pham 0 Comments 0801002 HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations) ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
GW842166X HES7 HGF Imatinib KIAA1516 Lamivudine MK-4827 MMP7 MMP9 monocytes Mouse monoclonal to CD13.COB10 reacts with CD13 ... Bispecific antibodies (BsAbs) are made to recognize and bind to two different antigens or epitopes. August 17, 2020 2:02 am ⋅ ... CD41 antigen acts as a receptor for fibrinogen fibrinectin and vitronectin and mediates platelet adhesion and aggregation. ... In chronic HBV disease (CHB), an insufficient HBV-specific T cell response can result in a big non-antigen-specific mobile ...
GW842166X HES7 HGF Imatinib KIAA1516 Lamivudine MK-4827 MMP7 MMP9 monocytes Mouse monoclonal to CD13.COB10 reacts with CD13 ... The antigen presentation ability of splenic cDCs isolated from Hsp70 Similarly. 1/3-/- mice was severely impaired compared to ... CD41 antigen acts as a receptor for fibrinogen fibrinectin and vitronectin and mediates platelet adhesion and aggregation. ... The antigens found in these research had been dinitrophenylated keyhole limpet haemocyanin (DNP-KLH) (KLH from Calbiochem NORTH ...
Antigen Affinity Purified. Description: A polyclonal antibody against LBP. Recognizes LBP from Human, Mouse, Rat. This antibody ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen Affinity Purified. Description: A polyclonal antibody against FBXW2. Recognizes FBXW2 from Human, Mouse, Rat. This ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification ... Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Antigen ELISA * Application of high-pressure treatment improves the in vitro protein digestibility of gel-based meat product ... CD (13) *CD34 Cells (15) *Cell Lysis (17) *Cellular Markers (29) *Cytology (14) ...
Briefly, after antigen retrieval in Tris-EDTA buffer (0.01 M) at 98°C, as indicated by the manufacturer, 3 μm FFPE tumor ... https://doi.org/10.1158/2159-8290.CD-13-0633.. 10. Duruisseaux M, McLeer-Florin A, Antoine M, Alavizadeh S, Poulot V, Lacave R ...
Cells were then air-dried, fixed and stained with 5 μg/ml mouse IgG1 monoclonal antibodies against CD13, CD14, CD32, CD163, ... Diagnostic Assay Development Clinical Diagnostic Antigens and Antibodies Leukemia Markers Tumor Markers Immunoglobulins ... Cells were then air-dried, fixed and stained with 5 μg/ml mouse IgG1 monoclonal antibodies against CD13, CD14, CD32, CD163, ... 5870-8008 recognizes an antigen of 150 kDa on macrophage cell membranes.. ...
MHC CLASS II ANTIGEN DRA 2 ;HLA-DR ANTIGENS-ASSOCIATED INVARIANT CHAIN, IA ANTIGEN-ASSOCIATED INVARIANT CHAIN\,II, P33, CD74, ... B ARG 197 CD 13 1 Y 1 B ARG 166 ? NE ? B ARG 197 NE 14 1 Y 1 B ARG 166 ? CZ ? B ARG 197 CZ 15 1 Y 1 B ARG 166 ? NH1 ? B ARG 197 ... HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II ... HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN\,DRB1-1 BETA CHAIN 25749.902 1 ...
150 kDa aminopeptidase N (APN). CD13 is expressed on the surface of early committed progenitors and mature granulocytes and ... unbiased of antigen, drives contaminated cells through germinal middle reactions in to the storage B cell area (3, 7). ... two longitudinally-associated Actin subunits KX2-391 LKB1 Met monocytes Mouse monoclonal to CD13.COB10 reacts with CD13 Mouse ...
  • There are currently no images for Aminopeptidase N/CD13 Antibody (NB100-63392G). (novusbio.com)
  • NB100-63392 recognizes bovine CD13, a 150 kD type II membrane protein shown to be a metallopeptidase in humans. (novusbio.com)
  • In cattle the antigen recognised by clone CC81 is primarily expressed on enterocytes and cells with a dendritic morphology in the small intestine. (novusbio.com)
  • Unlike myeloid dendritic cells, myeloid antigens like CD11b, CD11c, CD13, CD14 and CD33 are not present on pDC surfaces. (wikipedia.org)
  • mDCs share markers in common with monocytes and granulocytes including CD13, CD33, and CD11b and perform the classical functions of DCs in taking up and presenting antigen on HLA class II molecules. (frontiersin.org)
  • In a cohort of 365 consecutively diagnosed Czech B-precursor ALL patients, we analyze distribution of MyAg+ cases and mutual relationship among CD13, CD15, CD33, CD65 and CD66c. (biomedcentral.com)
  • Erythroid precursors are classically negative for myeloid associated antigens such as CD13, CD33, and MPO. (omicsonline.org)
  • Absence of prognostic impact of CD13 and/or CD33 antigen expression in adult acute lymphoblastic leukemia. (haematologica.org)
  • RESULTS: Immunophenotyping disclosed positivity for CD33 or CD13 and for the CD34 stem cell antigen in all cases tested. (haematologica.org)
  • We here present a rare case of MPAL with t(9;22)(q34;q11.2);BCR-ABL1 and unusual B/T immunophenotype along with aberrant expression of CD13, CD33, and CD56. (springer.com)
  • IPT profile rendered a diagnosis of MPAL B/T lineage with aberrant expression of CD13, CD33, and CD56. (springer.com)
  • If the only T cell markers present are CD4 and CD7, the leukemia cells must also lack the myeloid markers CD33 and/or CD13. (mdanderson.org)
  • Flow cytometry on the CSF confirmed the presence of a myeloblast population with 14% blasts with expression of CD13, CD33, CD34, CD45 and Human Leukocyte Antigen - DR isotype (HLADR). (bmj.com)
  • Ph+ myeloblasts co-expressed myeloid and B-lymphoid antigens (CD10, CD13, CD19 and CD33). (elsevier.com)
  • The incubation of living fibroblasts with an anti-CD13 antibody on ice gave punctate labeling that was evenly distributed on the cell surface, but raising the temperature to 37 degrees C before fixation caused aggregation of the labeling. (nih.gov)
  • Clone REAL312 is an antibody fragment derived from the full CD13 antibody molecule. (miltenyibiotec.com)
  • This antibody is a monoclonal mixture of FITC-conjugated CD7 (clone MG34, isotype IgG2a) and PE-conjugated CD13 (clone E735, isotype IgG1). (thermofisher.com)
  • This antibody recognizes the human CD13 cell surface glycoprotein, a 150kD molecule expressed by granulocytes and monocytes, and by myeloid leukemia cells. (thermofisher.com)
  • CD13 antibody LS-C759281 is an FITC-conjugated mouse monoclonal antibody to CD13 (ANPEP) from human. (lsbio.com)
  • The antibody WM15 recognises an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors. (exbio.cz)
  • human kidney tissue were subjected to SDS PAGE followed by western blot with 14553-1-AP (CD13 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 14553-1-AP (CD13 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 14553-1-AP (CD13 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
  • Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using 14553-1-AP (CD13 antibody) at dilution of 1:50 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). (ptglab.com)
  • 1X10^6 HEK-293 cells were stained with 0.2ug CD13 antibody (14553-1-AP, red) and control antibody (blue). (ptglab.com)
  • Second, in an effort to focus our recombinant antibody expression efforts on those B cells that displayed evidence of clonal expansion driven by antigen stimulation, we performed deep sequencing of the Ig genes of B cells collected from seven different tumors. (cancerindex.org)
  • Patients with leukemias that express the progenitor cell antigen CD34 and/or the P-glycoprotein (MDR1 gene product) have an inferior outcome. (rexhealth.com)
  • 3 These cells are identified in vitro by their ability to form colony-forming unit fibroblasts (CFU-F) and, phenotypically, by their expression of surface markers, such as CD105, CD73, CD90, integrins and adhesion molecules in addition to the absence of CD14, CD34 and CD45 haematopoietic-related antigen. (bmj.com)
  • Flow cytometric analysis revealed approximately 82% of cells in blast region expressing dim CD13, heterogeneous CD117 , moderate CD38, dim CD34, MPO positive, dim CD19, and negative for human leukocyte antigen - antigen D-related. (thefreedictionary.com)
  • MVs from patients specifically expressed tumor-related antigens, such as CD19 in B cell neoplasms, CD38 in MM, CD13 in myeloid tumors, and CD30 in HL. (springer.com)
  • Flow cytometry analysis (surface staining) of human peripheral blood leukocytes with anti-CD13 (WM15) biotin, streptavidin-APC. (exbio.cz)
  • The cells are positive for the beta-2-microglobulin, Leu12, My7 (CD13), OKT9 (CD71), OKT10 (CD38) and CALLA (CD10) antigens. (atcc.org)
  • In cattle the antigen recognised by clone CC81 is primarily expressed on enterocytes and cells with a dendritic morphology in the small intestine. (novusbio.com)
  • in this patient, the only positive antigens identified by immunophenotyping were CD13, NG2 HLA-DR, and CD38. (sigmaaldrich.com)
  • In the quantitative comparison of myeloid antigen, the expression of CD13 and CD38 were relatively increasedin the rote non-treated cells. (nii.ac.jp)
  • Efficient vaccination against infectious agents and tumors depends on specific antigen targeting to dendritic cells (DCs). (asm.org)
  • The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis has not been investigated. (asm.org)
  • Seliger B , Ruiz-Cabello F, Garrido F. IFN inducibility of major histocompatibility antigens in tumors. (uni-halle.de)
  • Seliger B . Different regulation of MHC class I antigen processing components in human tumors. (uni-halle.de)
  • Moreover, highly efficient antigen delivery to human DCs with recombinant human coronavirus 229E and specific stimulation of human CD8 + T cells revealed that this approach is exceptionally well suited for translation into human vaccine studies. (asm.org)
  • First, we cloned VH and VL genes from single intratumoral B lymphocytes isolated from one lung tumor, expressed the genes as recombinant mAbs, and used the mAbs to identify the cognate tumor antigens. (cancerindex.org)
  • Our analysis of bone marrow samples from 50 patients with MDS showed aberrant expression of differentiation antigens in the myelomonocytic lineage. (bloodjournal.org)
  • The CD antigens / Cluster of differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. (sinobiological.com)
  • CD13 is thought to be involved in the metabolism of many regulatory peptides and functions in antigen processing and the cleavage of chemokines such as MIP-1. (biolegend.com)
  • CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal/tumoricidal activities. (fishersci.com)
  • Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. (abcam.com)
  • CD13 plays a role in the terminal degradation of peptides, antigen processing, and chemokine cleavage, and cellular adhesion. (peprotech.com)
  • CD13 is reported to have many different functions including degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and adhesion and migration of cells. (fluidigm.com)
  • Leukemic presentation is very rare, and in particular, the null phenotype ALCL without typical anaplastic morphology together with aberrant expression of CD13 and/or CD11b represents a diagnostic challenge. (sigmaaldrich.com)
  • Aberrant expression of myeloid antigens (MyAgs) on acute lymphoblastic leukemia (ALL) cells is a well-documented phenomenon, although its regulating mechanisms are unclear. (biomedcentral.com)
  • As mentioned earlier, maturation also induces the expression of both MHC Class I and Class II molecules in pDCs as well, which allows the cell to optimize its antigen-presenting abilities. (wikipedia.org)
  • In addition, changes in the expression of basophil surface's molecules are observed: some antigens appear de novo (CD63, CD107a), and other increase their expression (CD13, CD203c). (termedia.pl)
  • The CD antigens are protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. (sinobiological.com)
  • Recent studies have indicated that CD13 has various functions, including roles in inflammatory and immunological responses, signal transduction, antigen processing, neuropeptide and cytokine degradation, angiogenesis and extracellular matrix degradation ( 16 , 17 ). (spandidos-publications.com)
  • Moreover, we investigated the relationship between APN/CD13 expression and tumor angiogenesis by measuring the IMD. (aacrjournals.org)
  • Our data suggest that APN/CD13 may be a new prognostic marker for patients with pancreatic carcinoma and may have a relationship with the angiogenesis for this cancer. (aacrjournals.org)
  • Granulocytic marker CD66c - Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is aberrantly expressed on ALL with strong correlation to genotype (negative in TEL/AML1 and MLL/AF4, positive in BCR/ABL and hyperdiploid cases). (biomedcentral.com)
  • Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD antigens molecule have been identified. (sinobiological.com)
  • Meissner M, Whiteside TL, van Kuik-Romein P, Valesky EM, van den Elsen PJ, Kaufmann R, Seliger B . Loss of interferon-gamma inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as well as epigenetic regulation. (uni-halle.de)
  • 1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13. (thefullwiki.org)
  • Recently, a second cell surface exopeptidase, prostate-specific membrane antigen (PSMA) or glutamate carboxypeptidase II, has been shown to display an expression pattern analogous to that of CD13/APN, where it is found in angiogenic but not normal tumor vasculature ( 17 , 18 , 49 , 70 ). (asm.org)
  • Defects in CD13 appear to be a cause of various types of leukemia or lymphoma. (miltenyibiotec.com)
  • The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation. (fishersci.com)
  • In addition, the relevance of myeloid antigen expression on both B-lineage and T-lineage ALL patients for treatment outcome was also analyzed. (hindawi.com)
  • The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives. (antibodies-online.com)
  • DCs are equipped with molecular sensors and antigen-processing machinery to recognize pathogens, integrate chemical information and guide the specificity, magnitude and polarity of immune responses. (biomedsearch.com)
  • In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2), Toll-like receptor (TLR) 7 and TLR9 within endosomal compartments. (wikipedia.org)
  • Uncommon leukemic case of anaplastic large cell lymphoma diagnosed through a typical chromosomal abnormality t(2;5) with a null phenotype and aberrant expression of NG2 and CD13. (sigmaaldrich.com)
  • We have shown that endothelial CD13/APN expression is induced in response to environmental angiogenic signals and that it plays an important functional role in endothelial cell invasion and morphogenesis ( 7 , 8 , 63 ). (asm.org)
  • Several recent studies prospectively isolated and evaluated putative hepatic CSCs by using surrogate characteristics such as xenograft tumor growth, expression of stem cell-associated antigens (e.g. (aacrjournals.org)
  • additionally, CD13 was reported to be correlated with malignant behavior in colon, prostate and non-small cell lung cancers ( 18 - 20 ). (spandidos-publications.com)
  • Inhibition of CD13 induced tumor cell apoptosis and resulted in tumor disruption, via blocking the ability of dormant CSCs to self-renew and re-initiate a tumor. (spandidos-publications.com)
  • Definition of cell immunophenotype in acute leukemias is commonly employed to identify malignant line, maturation stage and finally pattern of antigen expression in individual patients what permits better monitoring of treatment and residual disease. (termedia.pl)
  • As a siganl, CD antigens usually initiated, altering the behavior of the cell. (sinobiological.com)
  • The FIX & PERM Cell Permeabilization Kit consists of matched Fixation Reagent (Medium A) and Permeabilization Reagent (Medium B) for simultaneous analysis of intracellular and cell-surface antigens in the same cell population (Figure 1) . (thermofisher.com)
  • Use of FIX & PERM Cell Permeabilization Kit for simultaneous surface antigen and intracellular antigen staining. (thermofisher.com)